TreeWAS – Variant ID: rs4252548

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability
M16 Coxarthrosis [arthrosis of hip]	1.000	0.000
M15-M19 Arthrosis	1.000	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	1.000	0.000
# Top node	1.000	0.000
Y83.1 Surgical operation with implant of artificial internal device	1.000	0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts	1.000	0.000
M16.9 Coxarthrosis, unspecified	1.000	0.000
M16.1 Other primary coxarthrosis	1.000	0.000
T84.0 Mechanical complication of internal joint prosthesis	1.000	0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes	1.000	0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified	1.000	0.000
M19 Other arthrosis	0.999	0.001
M19.9 Arthrosis, unspecified	0.998	0.002
Chapter XX External causes of morbidity and mortality	0.998	0.002
Y83 Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure	0.997	0.003
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure	0.997	0.003
Chapter IX Diseases of the circulatory system	0.995	0.005
I60-I69 Cerebrovascular diseases	0.995	0.005
M45-M49 Spondylopathies	0.984	0.016
M20-M25 Other joint disorders	0.975	0.025
M47 Spondylosis	0.966	0.034
M20 Acquired deformities of fingers and toes	0.964	0.036
M19.94 Arthrosis, unspecified (Hand)	0.960	0.040
Chapter VII Diseases of the eye and adnexa	0.960	0.040
I69 Sequelae of cerebrovascular disease	0.959	0.041
M47.8 Other spondylosis	0.958	0.042
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts	0.953	0.047
H53-H54 Visual disturbances and blindness	0.947	0.053
H53 Visual disturbances	0.941	0.059
I67 Other cerebrovascular diseases	0.941	0.059
I63 Cerebral infarction	0.939	0.061
M05-M14 Inflammatory polyarthropathies	0.935	0.065
M40-M43 Deforming dorsopathies	0.929	0.071
M19.97 Arthrosis, unspecified (Ankle and foot)	0.928	0.072
I05-I09 Chronic rheumatic heart diseases	0.925	0.075
M16.0 Primary coxarthrosis, bilateral	0.920	0.080
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction	0.916	0.084
M47.82 Other spondylosis (Cervical region)	0.911	0.089
M20.1 Hallux valgus (acquired)	0.910	0.090
I67.1 Cerebral aneurysm, nonruptured	0.908	0.092
H53.8 Other visual disturbances	0.897	0.103
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction	0.895	0.105
M50-M54 Other dorsopathies	0.891	0.109
M41 Scoliosis	0.887	0.113
M47.86 Other spondylosis (Lumbar region)	0.885	0.115
Y83.2 Surgical operation with anastomosis, bypass or graft	0.878	0.122
M13 Other arthritis	0.874	0.126
I08 Multiple valve diseases	0.871	0.129
M70-M79 Other soft tissue disorders	0.871	0.129
M19.99 Arthrosis, unspecified (Site unspecified)	0.867	0.133
M20.3 Other deformity of hallux (acquired)	0.864	0.136
I65.2 Occlusion and stenosis of carotid artery	0.859	0.141
M41.9 Scoliosis, unspecified	0.857	0.143
T36-T50 Poisoning by drugs, medicaments and biological substances	0.852	0.148
H53.2 Diplopia	0.850	0.150
T84.4 Mechanical complication of other internal orthopaedic devices, imnplants and grafts	0.850	0.150
S40-S49 Injuries to the shoulder and upper arm	0.846	0.154
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.844	0.156
M17 Gonarthrosis [arthrosis of knee]	0.842	0.158
T85 Complications of other internal prosthetic devices, implants and grafts	0.839	0.161
M19.98 Arthrosis, unspecified (Other)	0.837	0.163
M19.95 Arthrosis, unspecified (Pelvic region and thigh)	0.837	0.163
M20.5 Other deformities of toe(s) (acquired)	0.837	0.163
I63.9 Cerebral infarction, unspecified	0.834	0.166
M19.96 Arthrosis, unspecified-Lower leg	0.830	0.170
M51 Other intervertebral disk disorders	0.828	0.172
M24 Other specific joint derangements	0.825	0.175
M48 Other spondylopathies	0.824	0.176
M19.2 Other secondary arthrosis	0.821	0.179
X60-X84 Intentional self-harm	0.821	0.179
Y83.0 Surgical operation with transplant of whole organ	0.821	0.179
M41.96 Scoliosis, unspecified (Lumbar region)	0.817	0.183
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified	0.813	0.187
M16.7 Other secondary coxarthrosis	0.810	0.190
M47.89 Other spondylosis (Site unspecified)	0.809	0.191
Chapter XXII Codes for special purposes	0.809	0.191
H53.1 Subjective visual disturbances	0.807	0.193
M79 Other soft tissue disorders, not elsewhere classified	0.807	0.193
M19.0 Primary arthrosis of other joints	0.804	0.196
M13.9 Arthritis, unspecified	0.803	0.197
M21 Other acquired deformities of limbs	0.801	0.199
T83 Complications of genito-urinary prosthetic devices, implants and grafts	0.800	0.200
Chapter V Mental and behavioural disorders	0.800	0.200
Z96.6 Presence of orthopaedic joint implants	0.800	0.200
M17.1 Other primary gonarthrosis	0.799	0.201
V10-V19 Pedal cyclist injured in transport accident	0.798	0.202
Chapter XII Diseases of the skin and subcutaneous tissue	0.797	0.203
X20-X29 Contact with venomous animals and plants	0.795	0.205
I08.3 Combined disorders of mitral, aortic and tricuspid valves	0.795	0.205
I69.1 Sequelae of intracerebral haemorrhage	0.793	0.207
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.788	0.212
M65-M68 Disorders of synovium and tendon	0.787	0.213
X40-X49 Accidental poisoning by and exposure to noxious substances	0.786	0.214
I63.5 Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries	0.785	0.215
M20.0 Deformity of finger(s)	0.785	0.215
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.785	0.215
H55-H59 Other disorders of eye and adnexa	0.784	0.216
H53.4 Visual field defects	0.783	0.217
M91-M94 Chondropathies	0.782	0.218
V20-V29 Motorcycle rider injured in transport accident	0.778	0.221
M06 Other rheumatoid arthritis	0.778	0.222
T15-T19 Effects of foreign body entering through natural orifice	0.778	0.222
T84.1 Mechanical complication of internal fixation device of bones of limb	0.775	0.225
I63.8 Other cerebral infarction	0.771	0.229
H43-H45 Disorders of vitreous body and globe	0.767	0.233
T86 Failure and rejection of transplanted organs and tissues	0.766	0.234
T84.5 Infection and inflammatory reaction due to internal joint prosthesis	0.764	0.236
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.763	0.237
S90-S99 Injuries to the ankle and foot	0.762	0.238
S10-S19 Injuries to the neck	0.758	0.242
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts	0.758	0.242
I69.0 Sequelae of subarachnoid haemorrhage	0.757	0.243
I69.8 Sequelae of other and unspecified cerebrovascular diseases	0.757	0.243
M19.90 Arthrosis, unspecified (Multiple sites)	0.756	0.244
M79.8 Other specified soft tissue disorders	0.756	0.244
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use	0.756	0.244
T84.2 Mechanical complication of internal fixation device of other bones	0.753	0.247
M51.2 Other specified intervertebral disk displacement	0.746	0.254
I70-I79 Diseases of arteries, arterioles and capillaries	0.745	0.255
S20-S29 Injuries to the thorax	0.745	0.255
I61 Intracerebral haemorrhage	0.741	0.259
M20.4 Other hammer toe(s) (acquired)	0.739	0.261
L40-L45 Papulosquamous disorders	0.737	0.263
M47.80 Other spondylosis (Multiple sites in spine)	0.737	0.263
T88 Other complications of surgical and medical care, not elsewhere classified	0.735	0.265
I62 Other nontraumatic intracranial haemorrhage	0.734	0.265
M47.2 Other spondylosis with radiculopathy	0.734	0.265
M16.3 Other dysplastic coxarthrosis	0.733	0.267
M86-M90 Other osteopathies	0.732	0.268
M80-M85 Disorders of bone density and structure	0.730	0.270
M41.99 Scoliosis, unspecified (Site unspecified)	0.726	0.274
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction	0.724	0.276
M13.94 Arthritis, unspecified (Hand)	0.723	0.277
M13.97 Arthritis, unspecified (Ankle and foot)	0.722	0.278
M13.0 Polyarthritis, unspecified	0.722	0.278
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.720	0.280
H46-H48 Disorders of optic nerve and visual pathways	0.719	0.281
M16.6 Other secondary coxarthrosis, bilateral	0.717	0.283
M16.5 Other posttraumatic coxarthrosis	0.717	0.283
M16.4 Posttraumatic coxarthrosis, bilateral	0.717	0.283
M16.2 Coxarthrosis resulting from dysplasia, bilateral	0.717	0.283
M15 Polyarthrosis	0.717	0.283
M60-M63 Disorders of muscles	0.717	0.283
M00-M03 Infectious arthropathies	0.717	0.283
Chapter XVI Certain conditions originating in the perinatal period	0.717	0.283
T84.9 Unspecified complication of internal orthopaedic prosthetic device, implant and graft	0.717	0.283
T84.3 Mechanical complication of other bone devices, implants and grafts	0.717	0.283
T33-T35 Frostbite	0.717	0.283
T26-T28 Burns and corrosions confined to eye and internal organs	0.717	0.283
T20-T25 Burns and corrosions of external body surface, specified by site	0.717	0.283
T00-T07 Injuries involving multiple body regions	0.717	0.283
T87 Complications peculiar to reattachment and amputation	0.717	0.283
T80 Complications following infusion, transfusion and therapeutic injection	0.717	0.283
M19.8 Other specified arthrosis	0.716	0.283
M19.1 Posttraumatic arthrosis of other joints	0.716	0.283
M19.92 Arthrosis, unspecified (Upper arm)	0.716	0.284
Y35-Y36 Legal intervention and operations of war	0.716	0.284
Y10-Y34 Event of undetermined intent	0.716	0.284
Y00-Y09 Assault	0.716	0.284
X85-X99 Assault	0.716	0.284
X58-X59 Accidental exposure to other and unspecified factors	0.716	0.284
X50-X57 Overexertion, travel and privation	0.716	0.284
X30-X39 Exposure to forces of nature	0.716	0.284
X10-X19 Contact with heat and hot substances	0.716	0.284
X00-X09 Exposure to smoke, fire and flames	0.716	0.284
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure	0.716	0.284
W75-W84 Other accidental threats to breathing	0.716	0.284
W65-W74 Accidental drowning and submersion	0.716	0.284
W50-W64 Exposure to animate mechanical forces	0.716	0.284
V98-V99 Other and unspecified transport accidents	0.716	0.284
V95-V97 Air and space transport accidents	0.716	0.284
V90-V94 Water transport accidents	0.716	0.284
V80-V89 Other land transport accidents	0.716	0.284
V70-V79 Bus occupant injured in transport accident	0.716	0.284
V60-V69 Occupant of heavy transport vehicle injured in transport accident	0.716	0.284
V50-V59 Occupant of pick-up truck or van injured in transport accident	0.716	0.284
V40-V49 Car occupant injured in transport accident	0.716	0.284
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident	0.716	0.284
V01-V09 Pedestrian injured in transport accident	0.716	0.284
M05 Seropositive rheumatoid arthritis	0.715	0.285
Y83.5 Amputation of limb(s)	0.715	0.285
I00-I02 Acute rheumatic fever	0.714	0.286
I68 Cerebrovascular disorders in diseases classified elsewhere	0.713	0.287
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction	0.713	0.287
M19.91 Arthrosis, unspecified (Shoulder region)	0.712	0.288
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.712	0.288
F30-F39 Mood [affective] disorders	0.712	0.288
M48.0 Spinal stenosis	0.709	0.291
I08.0 Disorders of both mitral and aortic valves	0.708	0.292
M49 Spondylopathies in diseases classified elsewhere	0.705	0.295
W20-W49 Exposure to inanimate mechanical forces	0.704	0.296
H53.9 Visual disturbance, unspecified	0.702	0.298
M76 Enthesopathies of lower limb, excluding foot	0.701	0.299
T85.8 Other complications of internal prosthetic devices, implants and grafts, not elsewhere classified	0.701	0.299
M54 Dorsalgia	0.700	0.300
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.699	0.301
M34 Systemic sclerosis	0.699	0.301
M33 Dermatopolymyositis	0.699	0.301
M32 Systemic lupus erythematosus	0.699	0.301
M30 Polyarteritis nodosa and related conditions	0.699	0.301
F20-F29 Schizophrenia, schizotypal and delusional disorders	0.697	0.303
M19.93 Arthrosis, unspecified (Forearm)	0.696	0.304
M19.27 Other secondary arthrosis (Ankle and foot)	0.693	0.307
M47.1 Other spondylosis with myelopathy	0.693	0.307
M47.0 Anterior spinal and vertebral artery compression syndromes	0.693	0.307
T85.6 Mechanical complication of other specified internal prosthetic devices, implants and grafts	0.692	0.308
M46 Other inflammatory spondylopathies	0.691	0.308
Y83.9 Surgical procedure, unspecified	0.691	0.309
I83 Varicose veins of lower extremities	0.690	0.310
M22 Disorders of patella	0.689	0.311
T79-T79 Certain early complications of trauma	0.688	0.312
I69.2 Sequelae of other nontraumatic intracranial haemorrhage	0.687	0.313
M47.88 Other spondylosis (Sacral and sacrococcygeal region)	0.687	0.313
M47.85 Other spondylosis (Thoracolumbar region)	0.687	0.313
M47.84 Other spondylosis (Thoracic region)	0.687	0.313
M47.83 Other spondylosis (Cervicothoracic region)	0.687	0.313
M47.81 Other spondylosis (Occipito-atlanto-axial region)	0.687	0.313
I05 Rheumatic mitral valve diseases	0.685	0.315
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle	0.685	0.315
M51.8 Other specified intervertebral disk disorders	0.683	0.317
M77 Other enthesopathies	0.682	0.318
M31 Other necrotising vasculopathies	0.680	0.319
I08.1 Disorders of both mitral and tricuspid valves	0.680	0.320
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use	0.679	0.321
I67.9 Cerebrovascular disease, unspecified	0.678	0.322
M06.9 Rheumatoid arthritis, unspecified	0.677	0.323
T66-T78 Other and unspecified effects of external causes	0.676	0.324
Q38-Q45 Other congenital malformations of the digestive system	0.676	0.324
I87 Other disorders of veins	0.676	0.324
H53.6 Night blindness	0.675	0.325
H53.5 Colour vision deficiencies	0.675	0.325
H53.3 Other disorders of binocular vision	0.675	0.325
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.674	0.325
I67.7 Cerebral arteritis, not elsewhere classified	0.674	0.326
I67.6 Nonpyogenic thrombosis of intracranial venous system	0.674	0.326
I67.5 Moyamoya disease	0.674	0.326
I67.4 Hypertensive encephalopathy	0.674	0.326
I67.3 Progressive vascular leukoencephalopathy	0.674	0.326
I67.0 Dissection of cerebral arteries, nonruptured	0.674	0.326
M19.04 Primary arthrosis of other joints (Hand)	0.674	0.326
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.673	0.327
L40 Psoriasis	0.673	0.327
I63.6 Cerebral infarction due to cerebral venous thrombosis, nonpyogenic	0.673	0.327
I63.4 Cerebral infarction due to embolism of cerebral arteries	0.673	0.327
I63.2 Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries	0.673	0.327
I63.1 Cerebral infarction due to embolism of precerebral arteries	0.673	0.327
I63.0 Cerebral infarction due to thrombosis of precerebral arteries	0.673	0.327
M47.87 Other spondylosis (Lumbosacral region)	0.672	0.327
M45 Ankylosing spondylitis	0.672	0.328
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.672	0.328
I60 Subarachnoid haemorrhage	0.672	0.328
S70-S79 Injuries to the hip and thigh	0.671	0.328
T83.0 Mechanical complication of urinary (indwelling) catheter	0.671	0.328
M14 Arthropathies in other diseases classified elsewhere	0.670	0.330
M12 Other specific arthropathies	0.670	0.330
M09 Juvenile arthritis in diseases classified elsewhere	0.670	0.330
M08 Juvenile arthritis	0.670	0.330
H15-H22 Disorders of sclera, cornea, iris and ciliary body	0.670	0.330
M24.8 Other specific joint derangements, not elsewhere classified	0.669	0.331
M42 Spinal osteochondrosis	0.666	0.334
M40 Kyphosis and lordosis	0.666	0.334
I95-I99 Other and unspecified disorders of the circulatory system	0.664	0.336
I09 Other rheumatic heart diseases	0.663	0.337
I06 Rheumatic aortic valve diseases	0.663	0.337
Q60-Q64 Congenital malformations of the urinary system	0.663	0.337
M79.1 Myalgia	0.663	0.337
M48.09 Spinal stenosis (Site unspecified)	0.663	0.337
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]	0.662	0.338
M24.2 Disorder of ligament	0.662	0.338
T63 Toxic effect of contact with venomous animals	0.662	0.338
I07 Rheumatic tricuspid valve diseases	0.661	0.339
T44 Poisoning by drugs primarily affecting the autonomic nervous system	0.660	0.340
I67.2 Cerebral atherosclerosis	0.660	0.340
M79.7 Fibromyalgia	0.660	0.340
T85.9 Unspecified complication of internal prosthetic device, implant and graft	0.659	0.341
F31 Bipolar affective disorder	0.659	0.341
I63.3 Cerebral infarction due to thrombosis of cerebral arteries	0.658	0.342
H55 Nystagmus and other irregular eye movements	0.658	0.342
S42 Fracture of shoulder and upper arm	0.657	0.343
I65.9 Occlusion and stenosis of unspecified precerebral artery	0.657	0.343
I65.8 Occlusion and stenosis of other precerebral artery	0.657	0.343
I65.3 Occlusion and stenosis of multiple and bilateral precerebral arteries	0.657	0.343
I65.1 Occlusion and stenosis of basilar artery	0.657	0.343
I65.0 Occlusion and stenosis of vertebral artery	0.657	0.343
H43 Disorders of vitreous body	0.656	0.344
M20.6 Acquired deformity of toe(s), unspecified	0.655	0.345
I86 Varicose veins of other sites	0.654	0.346
V18 Pedal cyclist injured in noncollision transport accident	0.654	0.346
M11 Other crystal arthropathies	0.654	0.346
M24.4 Recurrent dislocation and subluxation of joint	0.653	0.347
S60-S69 Injuries to the wrist and hand	0.653	0.347
M13.95 Arthritis, unspecified (Pelvic region and thigh)	0.653	0.347
X63 Intentional self-poisoning by and exposure to other drugs acting on the autonomic nervous system	0.651	0.349
X23 Contact with hornets, wasps and bees	0.650	0.350
I82 Other venous embolism and thrombosis	0.650	0.350
M96 Postprocedural musculoskeletal disorders, not elsewhere classified	0.648	0.351
X62 Intentional self-poisoning by and exposure to narcotics and psychodysleptics [hallucinogens], not elsewhere classified	0.647	0.352
M07 Psoriatic and enteropathic arthropathies	0.647	0.353
H30-H36 Disorders of choroid and retina	0.647	0.353
T84.6 Infection and inflammatory reaction due to internal fixation device [any site]	0.644	0.356
H53.0 Amblyopia ex anopsia	0.644	0.356
M79.84 Other specified soft tissue disorders (Hand)	0.643	0.357
L20-L30 Dermatitis and eczema	0.641	0.359
M21.3 Wrist or foot drop (acquired)	0.640	0.360
I83.1 Varicose veins of lower extremities with inflammation	0.640	0.360
W00-W19 Falls	0.639	0.361
S49 Other and unspecified injuries of shoulder and upper arm	0.638	0.361
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs	0.637	0.363
H10-H13 Disorders of conjunctiva	0.636	0.364
M41.8 Other forms of scoliosis	0.636	0.364
M41.5 Other secondary scoliosis	0.636	0.364
M41.4 Neuromuscular scoliosis	0.636	0.364
M41.3 Thoracogenic scoliosis	0.636	0.364
M41.2 Other idiopathic scoliosis	0.636	0.364
M41.1 Juvenile idiopathic scoliosis	0.636	0.364
M41.0 Infantile idiopathic scoliosis	0.636	0.364
I67.8 Other specified cerebrovascular diseases	0.635	0.365
X41 Accidental poisoning by and exposure to antiepileptic, sedative-hypnotic, anti-Parkinsonism and psychotropic drugs, not elsewhere classified	0.634	0.366
Y60-Y69 Misadventures to patients during surgical and medical care	0.634	0.366
M35 Other systemic involvement of connective tissue	0.634	0.366
T83.4 Mechanical complication of other prosthetic devices, implants and grafts in genital tract	0.633	0.367
I80 Phlebitis and thrombophlebitis	0.633	0.367
I69.3 Sequelae of cerebral infarction	0.632	0.368
M79.87 Other specified soft tissue disorders (Ankle and foot)	0.631	0.369
M17.0 Primary gonarthrosis, bilateral	0.628	0.372
L40.9 Psoriasis, unspecified	0.627	0.373
M13.8 Other specified arthritis	0.627	0.373
M13.1 Monoarthritis, not elsewhere classified	0.627	0.373
T85.4 Mechanical complication of breast prosthesis and implant	0.626	0.374
M53 Other dorsopathies, not elsewhere classified	0.625	0.375
I08.9 Multiple valve disease, unspecified	0.624	0.375
I08.8 Other multiple valve diseases	0.624	0.375
I08.2 Disorders of both aortic and tricuspid valves	0.624	0.375
M73 Soft tissue disorders in diseases classified elsewhere	0.624	0.375
M79.2 Neuralgia and neuritis, unspecified	0.623	0.377
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.623	0.377
M51.0 Lumbar and other intervertebral disk disorders with myelopathy	0.623	0.377
V23 Motorcycle rider injured in collision with car, pick-up truck or van	0.621	0.379
T18 Foreign body in alimentary tract	0.617	0.383
M70 Soft tissue disorders related to use, overuse and pressure	0.617	0.383
M19.01 Primary arthrosis of other joints (Shoulder region)	0.617	0.383
M43 Other deforming dorsopathies	0.616	0.384
M94 Other disorders of cartilage	0.615	0.384
I77 Other disorders of arteries and arterioles	0.615	0.385
M41.98 Scoliosis, unspecified (Sacral and sacrococcygeal region)	0.614	0.386
M41.97 Scoliosis, unspecified (Lumbosacral region)	0.614	0.386
M41.95 Scoliosis, unspecified (Thoracolumbar region)	0.614	0.386
M41.94 Scoliosis, unspecified (Thoracic region)	0.614	0.386
M41.93 Scoliosis, unspecified (Cervicothoracic region)	0.614	0.386
M41.92 Scoliosis, unspecified (Cervical region)	0.614	0.386
M41.91 Scoliosis, unspecified (Occipito-atlanto-axial region)	0.614	0.386
M41.90 Scoliosis, unspecified (Multiple sites in spine)	0.614	0.386
M13.00 Polyarthritis, unspecified (Multiple sites)	0.613	0.387
L80-L99 Other disorders of the skin and subcutaneous tissue	0.613	0.387
M67 Other disorders of synovium and tendon	0.612	0.388
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.611	0.389
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.611	0.389
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.611	0.389
T46 Poisoning by agents primarily affecting the cardiovascular system	0.611	0.389
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.611	0.389
T41 Poisoning by anaesthetics and therapeutic gases	0.611	0.389
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.611	0.389
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.611	0.389
T36 Poisoning by systemic antibiotics	0.611	0.389
S50-S59 Injuries to the elbow and forearm	0.609	0.391
I64 Stroke, not specified as haemorrhage or infarction	0.608	0.391
Y83.3 Surgical operation with formation of external stoma	0.607	0.393
H49 Paralytic strabismus	0.607	0.393
S48 Traumatic amputation of shoulder and upper arm	0.606	0.393
S46 Injury of muscle and tendon at shoulder and upper arm level	0.606	0.393
S45 Injury of blood vessels at shoulder and upper arm level	0.606	0.393
S44 Injury of nerves at shoulder and upper arm level	0.606	0.393
S41 Open wound of shoulder and upper arm	0.606	0.393
S40 Superficial injury of shoulder and upper arm	0.606	0.393
S47 Crushing injury of shoulder and upper arm	0.606	0.393
H25-H28 Disorders of lens	0.606	0.394
M21.0 Valgus deformity, not elsewhere classified	0.606	0.394
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere	0.605	0.395
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.605	0.395
Q80-Q89 Other congenital malformations	0.605	0.395
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.605	0.395
Q35-Q37 Cleft lip and cleft palate	0.605	0.395
Q30-Q34 Congenital malformations of the respiratory system	0.605	0.395
Q00-Q07 Congenital malformations of the nervous system	0.605	0.395
M17.5 Other secondary gonarthrosis	0.604	0.396
M17.4 Other secondary gonarthrosis, bilateral	0.604	0.396
M17.3 Other posttraumatic gonarthrosis	0.604	0.396
M17.2 Posttraumatic gonarthrosis, bilateral	0.604	0.396
F29 Unspecified nonorganic psychosis	0.602	0.398
T85.2 Mechanical complication of intraocular lens	0.602	0.398
T85.1 Mechanical complication of implanted electronic stimulator of nervous system	0.602	0.398
T85.0 Mechanical complication of ventricular intracranial (communicating) shunt	0.602	0.398
Chapter VI Diseases of the nervous system	0.601	0.399
M13.96 Arthritis, unspecified (Lower leg)	0.601	0.399
I10-I15 Hypertensive diseases	0.600	0.400
S00-S09 Injuries to the head	0.599	0.401
M79.89 Other specified soft tissue disorders (Site unspecified)	0.599	0.401
L43 Lichen planus	0.599	0.401
Q50-Q56 Congenital malformations of genital organs	0.598	0.402
M71 Other bursopathies	0.597	0.402
M21.1 Varus deformity, not elsewhere classified	0.597	0.403
M51.3 Other specified intervertebral disk degeneration	0.594	0.406
M51.1 Lumbar and other intervertebral disk disorders with radiculopathy	0.594	0.406
M51.9 Intervertebral disk disorder, unspecified	0.594	0.406
M51.4 Schmorl's nodes	0.594	0.406
Chapter I Certain infectious and parasitic diseases	0.594	0.406
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors	0.594	0.406
M65 Synovitis and tenosynovitis	0.593	0.407
M24.9 Joint derangement, unspecified	0.592	0.408
M24.7 Protrusio acetabuli	0.592	0.408
M24.6 Ankylosis of joint	0.592	0.408
M24.5 Contracture of joint	0.592	0.408
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.592	0.408
M24.0 Loose body in joint	0.592	0.408
I74 Arterial embolism and thrombosis	0.592	0.408
S27 Injury of other and unspecified intrathoracic organs	0.591	0.409
M48.9 Spondylopathy, unspecified	0.591	0.409
M48.8 Other specified spondylopathies	0.591	0.409
M48.5 Collapsed vertebra, not elsewhere classified	0.591	0.409
M48.4 Fatigue fracture of vertebra	0.591	0.409
M48.3 Traumatic spondylopathy	0.591	0.409
M48.2 Kissing spine	0.591	0.409
M48.1 Ankylosing hyperostosis [Forestier]	0.591	0.409
S32 Fracture of lumbar spine and pelvis	0.590	0.410
M19.29 Other secondary arthrosis (Site unspecified)	0.589	0.411
M19.28 Other secondary arthrosis (Other)	0.589	0.411
M19.26 Other secondary arthrosis of other joints-Lower leg	0.589	0.411
M19.25 Other secondary arthrosis (Pelvic region and thigh)	0.589	0.411
M19.24 Other secondary arthrosis (Hand)	0.589	0.411
M19.23 Other secondary arthrosis (Forearm)	0.589	0.411
M19.22 Other secondary arthrosis (Upper arm)	0.589	0.411
M19.21 Other secondary arthrosis (Shoulder region)	0.589	0.411
M19.20 Other secondary arthrosis (Multiple sites)	0.589	0.411
X84 Intentional self-harm by unspecified means	0.588	0.411
X83 Intentional self-harm by other specified means	0.588	0.411
X82 Intentional self-harm by crashing of motor vehicle	0.588	0.411
X81 Intentional self-harm by jumping or lying before moving object	0.588	0.411
X80 Intentional self-harm by jumping from a high place	0.588	0.411
X79 Intentional self-harm by blunt object	0.588	0.411
X78 Intentional self-harm by sharp object	0.588	0.411
X77 Intentional self-harm by steam, hot vapours and hot objects	0.588	0.411
X76 Intentional self-harm by smoke, fire and flames	0.588	0.411
X75 Intentional self-harm by explosive material	0.588	0.411
X74 Intentional self-harm by other and unspecified firearm discharge	0.588	0.411
X73 Intentional self-harm by rifle, shotgun and larger firearm discharge	0.588	0.411
X72 Intentional self-harm by handgun discharge	0.588	0.411
X71 Intentional self-harm by drowning and submersion	0.588	0.411
X70 Intentional self-harm by hanging, strangulation and suffocation	0.588	0.411
X69 Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances	0.588	0.411
X68 Intentional self-poisoning by and exposure to pesticides	0.588	0.411
X67 Intentional self-poisoning by and exposure to other gases and vapours	0.588	0.411
X66 Intentional self-poisoning by and exposure to organic solvents and halogenated hydrocarbons and their vapours	0.588	0.411
X65 Intentional self-poisoning by and exposure to alcohol	0.588	0.411
X64 Intentional self-poisoning by and exposure to other and unspecified drugs, medicaments and biological substances	0.588	0.411
X61 Intentional self-poisoning by and exposure to antiepileptic, sedative-hypnotic, anti-Parkinsonism and psychotropic drugs, not elsewhere classified	0.588	0.411
X60 Intentional self-poisoning by and exposure to nonopioid analgesics, antipyretics and antirheumatics	0.588	0.411
T39.1 4-Aminophenol derivatives	0.588	0.412
M47.26 Other spondylosis with radiculopathy (Lumbar region)	0.588	0.412
U80 Agent resistant to penicillin and related antibiotics	0.587	0.413
M79.82 Other specified soft tissue disorders (Upper arm)	0.586	0.414
S12 Fracture of neck	0.585	0.415
I85 Oesophageal varices	0.584	0.416
H40-H42 Glaucoma	0.583	0.417
I88 Nonspecific lymphadenitis	0.583	0.417
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.583	0.417
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.583	0.417
Y79 Orthopaedic devices associated with adverse incidents	0.582	0.418
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue	0.581	0.419
T86.1 Kidney transplant failure and rejection	0.581	0.419
M76.6 Achilles tendinitis	0.580	0.420
V18.2 Unspecified pedal cyclist injured in nontraffic accident	0.579	0.420
M79.9 Soft tissue disorder, unspecified	0.578	0.421
M79.5 Residual foreign body in soft tissue	0.578	0.421
M79.4 Hypertrophy of (infrapatellar) fat pad	0.578	0.421
M79.3 Panniculitis, unspecified	0.578	0.421
I87.8 Other specified disorders of veins	0.578	0.422
L27 Dermatitis due to substances taken internally	0.577	0.423
M19.09 Primary arthrosis of other joints (Site unspecified)	0.577	0.423
M19.08 Primary arthrosis of other joints (Other)	0.577	0.423
M19.06 Primary arthrosis of other joints-Lower leg	0.577	0.423
M19.05 Primary arthrosis of other joints (Pelvic region and thigh)	0.577	0.423
M19.03 Primary arthrosis of other joints (Forearm)	0.577	0.423
M19.02 Primary arthrosis of other joints (Upper arm)	0.577	0.423
M19.00 Primary arthrosis of other joints (Multiple sites)	0.577	0.423
M13.93 Arthritis, unspecified (Forearm)	0.576	0.424
M13.92 Arthritis, unspecified (Upper arm)	0.576	0.424
L92 Granulomatous disorders of skin and subcutaneous tissue	0.576	0.424
S99 Other and unspecified injuries of ankle and foot	0.575	0.425
M10 Gout	0.575	0.425
I81 Portal vein thrombosis	0.575	0.425
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.575	0.425
M21.9 Acquired deformity of limb, unspecified	0.574	0.425
M21.8 Other specified acquired deformities of limbs	0.574	0.425
M21.7 Unequal limb length (acquired)	0.574	0.425
M21.6 Other acquired deformities of ankle and foot	0.574	0.425
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot	0.574	0.425
M21.4 Flat foot [pes planus] (acquired)	0.574	0.425
M21.2 Flexion deformity	0.574	0.425
T83.9 Unspecified complication of genito-urinary prosthetic device, implant and graft	0.574	0.426
T83.6 Infection and inflammatory reaction due to prosthetic device, implant and graft in genital tract	0.574	0.426

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations