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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs4388254
log Bayes Factor = 6.9552
Chromosome 5   position 133,428,601  (GRCh37) Explore rs4388254 on Ensembl!
Variant rs4388254 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
M15-M19 Arthrosis
0.999 0.001 0.000
Chapter XXI Factors influencing health status and contact with health services
0.998 0.002 0.000
M19 Other arthrosis
0.998 0.002 0.000
Chapter XX External causes of morbidity and mortality
0.994 0.006 0.000
M19.9 Arthrosis, unspecified
0.993 0.007 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.986 0.014 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.983 0.017 0.000
Chapter II Neoplasms
0.982 0.018 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.978 0.022 0.000
M18 Arthrosis of first carpometacarpal joint
0.975 0.025 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.972 0.028 0.000
Y43 Primarily systemic agents
0.971 0.029 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.970 0.030 0.000
Chapter I Certain infectious and parasitic diseases
0.968 0.032 0.000
M05-M14 Inflammatory polyarthropathies
0.966 0.034 0.000
Z30-Z39 Persons encountering health services in circumstances related to reproduction
0.961 0.039 0.000
M18.9 Arthrosis of first carpometacarpal joint, unspecified
0.960 0.040 0.000
Z70-Z76 Persons encountering health services in other circumstances
0.959 0.041 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.956 0.044 0.000
Y43.3 Other antineoplastic drugs
0.951 0.049 0.000
M19.91 Arthrosis, unspecified (Shoulder region)
0.947 0.053 0.000
M19.98 Arthrosis, unspecified (Other)
0.939 0.061 0.000
D70 Agranulocytosis
0.936 0.064 0.000
Z60 Problems related to social environment
0.932 0.068 0.000
Z33 Pregnant state, incidental
0.926 0.074 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.923 0.077 0.000
Chapter V Mental and behavioural disorders
0.923 0.077 0.000
Z34 Supervision of normal pregnancy
0.922 0.078 0.000
M86-M90 Other osteopathies
0.920 0.080 0.000
C50-C50 Malignant neoplasm of breast
0.919 0.081 0.000
C83 Diffuse non-Hodgkin's lymphoma
0.914 0.086 0.000
Chapter VIII Diseases of the ear and mastoid process
0.914 0.086 0.000
Z50 Care involving use of rehabilitation procedures
0.909 0.091 0.000
Z40-Z54 Persons encountering health services for specific procedures and health care
0.907 0.093 0.000
M13 Other arthritis
0.906 0.094 0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.897 0.103 0.000
Y52 Agents primarily affecting the cardiovascular system
0.896 0.104 0.000
Z60.2 Living alone
0.896 0.104 0.000
Z50.9 Care involving use of rehabilitation procedure, unspecified
0.891 0.109 0.000
B95-B98 Bacterial, viral and other infectious agents
0.888 0.112 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.887 0.113 0.000
Z34.8 Supervision of other normal pregnancy
0.884 0.116 0.000
Z50.1 Other physical therapy
0.882 0.118 0.000
C50 Malignant neoplasm of breast
0.875 0.125 0.000
H90-H95 Other disorders of ear
0.874 0.126 0.000
M19.0 Primary arthrosis of other joints
0.864 0.136 0.000
O60-O75 Complications of labour and delivery
0.861 0.139 0.000
M19.92 Arthrosis, unspecified (Upper arm)
0.859 0.141 0.000
Chapter VII Diseases of the eye and adnexa
0.857 0.143 0.000
M19.94 Arthrosis, unspecified (Hand)
0.857 0.143 0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters
0.856 0.144 0.000
M06 Other rheumatoid arthritis
0.854 0.146 0.000
Z63 Other problems related to primary support group, including family circumstances
0.851 0.149 0.000
M19.1 Posttraumatic arthrosis of other joints
0.850 0.150 0.000
Z74 Problems related to care-provider dependency
0.849 0.151 0.000
Y40 Systemic antibiotics
0.845 0.155 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.844 0.156 0.000
Z57 Occupational exposure to risk-factors
0.843 0.157 0.000
M13.9 Arthritis, unspecified
0.840 0.160 0.000
D72 Other disorders of white blood cells
0.840 0.160 0.000
Z73 Problems related to life-management difficulty
0.838 0.162 0.000
B35-B49 Mycoses
0.837 0.163 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.836 0.164 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.830 0.169 0.000
A30-A49 Other bacterial diseases
0.828 0.171 0.000
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.828 0.172 0.000
O34 Maternal care for known or suspected abnormality of pelvic organs
0.827 0.173 0.000
C83.3 Large cell (diffuse)
0.823 0.177 0.000
C50.4 Upper-outer quadrant of breast
0.823 0.177 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.823 0.177 0.000
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
0.822 0.178 0.000
Z71 Persons encountering health services for other counselling and medical advice, not elsewhere classified
0.821 0.179 0.000
H53-H54 Visual disturbances and blindness
0.817 0.183 0.000
C50.1 Central portion of breast
0.816 0.184 0.000
M89 Other disorders of bone
0.816 0.184 0.000
Z31 Procreative management
0.816 0.184 0.000
H91 Other hearing loss
0.805 0.195 0.000
Z50.4 Psychotherapy, not elsewhere classified
0.802 0.198 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.800 0.200 0.000
M19.93 Arthrosis, unspecified (Forearm)
0.796 0.204 0.000
Z41 Procedures for purposes other than remedying health state
0.795 0.205 0.000
B95.6 Staphylococcus aureus as the cause of diseases classified to other chapters
0.793 0.207 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.793 0.207 0.000
C81 Hodgkin's disease
0.791 0.209 0.000
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.791 0.209 0.000
H53 Visual disturbances
0.791 0.209 0.000
X60-X84 Intentional self-harm
0.790 0.210 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.788 0.212 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.787 0.213 0.000
M60-M63 Disorders of muscles
0.787 0.213 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.786 0.214 0.000
M11 Other crystal arthropathies
0.784 0.216 0.000
C15-C26 Malignant neoplasms of digestive organs
0.782 0.218 0.000
Y43.1 Antineoplastic antimetabolites
0.778 0.222 0.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes
0.778 0.222 0.000
A80-A89 Viral infections of the central nervous system
0.776 0.224 0.000
W00-W19 Falls
0.775 0.225 0.000
H90 Conductive and sensorineural hearing loss
0.775 0.225 0.000
M65-M68 Disorders of synovium and tendon
0.774 0.226 0.000
F17 Mental and behavioural disorders due to use of tobacco
0.773 0.227 0.000
D73 Diseases of spleen
0.772 0.228 0.000
C83.8 Other types of diffuse non-Hodgkin's lymphoma
0.770 0.230 0.000
Y52.2 Other antidysrhythmic drugs, not elsewhere classified
0.769 0.231 0.000
C88 Malignant immunoproliferative diseases
0.768 0.232 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.768 0.232 0.000
H53.8 Other visual disturbances
0.767 0.233 0.000
C85.1 B-cell lymphoma, unspecified
0.767 0.233 0.000
Z34.9 Supervision of normal pregnancy, unspecified
0.764 0.236 0.000
Z50.2 Alcohol rehabilitation
0.763 0.237 0.000
Y43.0 Antiallergic and antiemetic drugs
0.763 0.237 0.000
O30 Multiple gestation
0.762 0.237 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.760 0.240 0.000
M91-M94 Chondropathies
0.759 0.241 0.000
Z75 Problems related to medical facilities and other health care
0.758 0.242 0.000
W20-W49 Exposure to inanimate mechanical forces
0.758 0.242 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.758 0.242 0.000
D72.8 Other specified disorders of white blood cells
0.757 0.243 0.000
O75 Other complications of labour and delivery, not elsewhere classified
0.756 0.244 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.754 0.246 0.000
O40 Polyhydramnios
0.751 0.249 0.000
Z76 Persons encountering health services in other circumstances
0.750 0.250 0.000
M90 Osteopathies in diseases classified elsewhere
0.748 0.252 0.000
O34.2 Maternal care due to uterine scar from previous surgery
0.746 0.254 0.000
O35 Maternal care for known or suspected foetal abnormality and damage
0.745 0.255 0.000
M14 Arthropathies in other diseases classified elsewhere
0.744 0.256 0.000
M18.0 Primary arthrosis of first carpometacarpal joints, bilateral
0.744 0.256 0.000
M19.17 Post-traumatic arthrosis of other joints (Ankle and foot)
0.744 0.256 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.744 0.256 0.000
M40-M43 Deforming dorsopathies
0.743 0.257 0.000
C15 Malignant neoplasm of oesophagus
0.741 0.259 0.000
X20-X29 Contact with venomous animals and plants
0.741 0.259 0.000
M06.9 Rheumatoid arthritis, unspecified
0.741 0.259 0.000
Y86 Sequelae of other accidents
0.740 0.260 0.000
M19.96 Arthrosis, unspecified-Lower leg
0.740 0.260 0.000
Y52.5 Other antihypertensive drugs, not elsewhere classified
0.740 0.260 0.000
D80-D89 Certain disorders involving the immune mechanism
0.739 0.261 0.000
O99.0 Anaemia complicating pregnancy, childbirth and the puerperium
0.737 0.263 0.000
A41 Other septicaemia
0.735 0.265 0.000
B97 Viral agents as the cause of diseases classified to other chapters
0.735 0.265 0.000
F30-F39 Mood [affective] disorders
0.732 0.268 0.000
F80-F89 Disorders of psychological development
0.732 0.268 0.000
Z58 Problems related to physical environment
0.730 0.270 0.000
Y44 Agents primarily affecting blood constituents
0.729 0.271 0.000
M89.9 Disorder of bone, unspecified
0.729 0.271 0.000
M13.93 Arthritis, unspecified (Forearm)
0.727 0.273 0.000
C77.0 Lymph nodes of head, face and neck
0.726 0.274 0.000
C77.1 Intrathoracic lymph nodes
0.726 0.274 0.000
H91.9 Hearing loss, unspecified
0.726 0.274 0.000
O44 Placenta praevia
0.726 0.274 0.000
D00-D09 In situ neoplasms
0.724 0.276 0.000
Z63.5 Disruption of family by separation and divorce
0.723 0.277 0.000
S90-S99 Injuries to the ankle and foot
0.723 0.277 0.000
M45-M49 Spondylopathies
0.722 0.277 0.000
Z74.2 Need for assistance at home and no other household member able to render care
0.722 0.278 0.000
M50-M54 Other dorsopathies
0.722 0.278 0.000
M13.1 Monoarthritis, not elsewhere classified
0.721 0.279 0.000
Y40.0 Penicillins
0.721 0.279 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.719 0.281 0.000
M19.07 Primary arthrosis of other joints (Ankle and foot)
0.719 0.281 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.718 0.281 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
M00-M03 Infectious arthropathies
0.717 0.283 0.000
M15 Polyarthrosis
0.716 0.283 0.000
B49 Unspecified mycosis
0.716 0.284 0.000
D55-D59 Haemolytic anaemias
0.716 0.284 0.000
M19.8 Other specified arthrosis
0.715 0.285 0.000
M19.2 Other secondary arthrosis
0.715 0.285 0.000
O62 Abnormalities of forces of labour
0.715 0.285 0.000
F12 Mental and behavioural disorders due to use of cannabinoids
0.715 0.285 0.000
Z41.1 Other plastic surgery for unacceptable cosmetic appearance
0.714 0.286 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.714 0.286 0.000
M05 Seropositive rheumatoid arthritis
0.713 0.286 0.000
O63 Long labour
0.713 0.287 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.713 0.287 0.000
Y35-Y36 Legal intervention and operations of war
0.713 0.287 0.000
Y10-Y34 Event of undetermined intent
0.713 0.287 0.000
Y00-Y09 Assault
0.713 0.287 0.000
X85-X99 Assault
0.713 0.287 0.000
X30-X39 Exposure to forces of nature
0.713 0.287 0.000
X10-X19 Contact with heat and hot substances
0.713 0.287 0.000
X00-X09 Exposure to smoke, fire and flames
0.713 0.287 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.713 0.287 0.000
W75-W84 Other accidental threats to breathing
0.713 0.287 0.000
W65-W74 Accidental drowning and submersion
0.713 0.287 0.000
W50-W64 Exposure to animate mechanical forces
0.713 0.287 0.000
V98-V99 Other and unspecified transport accidents
0.713 0.287 0.000
V95-V97 Air and space transport accidents
0.713 0.287 0.000
V90-V94 Water transport accidents
0.713 0.287 0.000
V70-V79 Bus occupant injured in transport accident
0.713 0.287 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.713 0.287 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.713 0.287 0.000
V40-V49 Car occupant injured in transport accident
0.713 0.287 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.713 0.287 0.000
V01-V09 Pedestrian injured in transport accident
0.713 0.287 0.000
M13.95 Arthritis, unspecified (Pelvic region and thigh)
0.712 0.288 0.000
C83.1 Small cleaved cell (diffuse)
0.711 0.289 0.000
B95.3 Streptococcus pneumoniae as the cause of diseases classified to other chapters
0.709 0.290 0.000
O85-O92 Complications predominantly related to the puerperium
0.709 0.291 0.000
Y52.3 Coronary vasodilators, not elsewhere classified
0.708 0.292 0.000
M19.04 Primary arthrosis of other joints (Hand)
0.708 0.292 0.000
Y59 Other and unspecified vaccines and biological substances
0.707 0.293 0.000
Y58 Bacterial vaccines
0.707 0.293 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.707 0.293 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.707 0.293 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.707 0.293 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.707 0.293 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.707 0.293 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.707 0.293 0.000
Y48 Anaesthetics and therapeutic gases
0.707 0.293 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.707 0.293 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.707 0.293 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.706 0.293 0.000
X50-X57 Overexertion, travel and privation
0.706 0.293 0.000
F17.1 Harmful use
0.706 0.294 0.000
Z65 Problems related to other psychosocial circumstances
0.705 0.295 0.000
Z64 Problems related to certain psychosocial circumstances
0.705 0.295 0.000
Z62 Other problems related to upbringing
0.705 0.295 0.000
Z61 Problems related to negative life events in childhood
0.705 0.295 0.000
Z59 Problems related to housing and economic circumstances
0.705 0.295 0.000
Z56 Problems related to employment and unemployment
0.705 0.295 0.000
Z55 Problems related to education and literacy
0.705 0.295 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.704 0.296 0.000
O72 Postpartum haemorrhage
0.703 0.297 0.000
Z31.0 Tuboplasty or vasoplasty after previous sterilisation
0.702 0.298 0.000
B99-B99 Other infectious diseases
0.702 0.298 0.000
C92 Myeloid leukaemia
0.701 0.298 0.000
M18.5 Other secondary arthrosis of first carpometacarpal joint
0.699 0.301 0.000
M18.4 Other secondary arthrosis of first carpometacarpal joints, bilateral
0.699 0.301 0.000
M18.3 Other posttraumatic arthrosis of first carpometacarpal joint
0.699 0.301 0.000
M18.2 Posttraumatic arthrosis of first carpometacarpal joints, bilateral
0.699 0.301 0.000
V80-V89 Other land transport accidents
0.699 0.301 0.000
B95.5 Unspecified streptococcus as the cause of diseases classified to other chapters
0.698 0.302 0.000
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.697 0.303 0.000
C95 Leukaemia of unspecified cell type
0.697 0.303 0.000
C94 Other leukaemias of specified cell type
0.697 0.303 0.000
C93 Monocytic leukaemia
0.697 0.303 0.000
C86 Other specified types of T/NK-cell lymphoma
0.697 0.303 0.000
C84 Peripheral and cutaneous T-cell lymphomas
0.697 0.303 0.000
Z71.4 Alcohol abuse counselling and surveillance
0.696 0.304 0.000
Y43.9 Primarily systemic agent, unspecified
0.696 0.304 0.000
Y43.8 Other primarily systemic agents, not elsewhere classified
0.696 0.304 0.000
Y43.6 Enzymes, not elsewhere classified
0.696 0.304 0.000
Y43.5 Acidifying and alkalising agents
0.696 0.304 0.000
Y43.4 Immunosuppressive agents
0.696 0.304 0.000
Y43.2 Antineoplastic natural products
0.696 0.304 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.694 0.305 0.000
M06.3 Rheumatoid nodule
0.694 0.306 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.694 0.306 0.000
B65-B83 Helminthiases
0.694 0.306 0.000
B50-B64 Protozoal diseases
0.694 0.306 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.694 0.306 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.694 0.306 0.000
A75-A79 Rickettsioses
0.694 0.306 0.000
A70-A74 Other diseases caused by chlamydiae
0.694 0.306 0.000
A65-A69 Other spirochaetal diseases
0.694 0.306 0.000
A20-A28 Certain zoonotic bacterial diseases
0.694 0.306 0.000
A15-A19 Tuberculosis
0.694 0.306 0.000
Z50.8 Care involving use of rehabilitation procedures
0.693 0.307 0.000
Y57 Other and unspecified drugs and medicaments
0.693 0.307 0.000
O46 Antepartum haemorrhage, not elsewhere classified
0.693 0.307 0.000
M12 Other specific arthropathies
0.692 0.307 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.692 0.307 0.000
M08 Juvenile arthritis
0.692 0.307 0.000
C50.3 Lower-inner quadrant of breast
0.692 0.308 0.000
M20-M25 Other joint disorders
0.692 0.308 0.000
C77.3 Axillary and upper limb lymph nodes
0.691 0.309 0.000
M13.94 Arthritis, unspecified (Hand)
0.690 0.310 0.000
H10-H13 Disorders of conjunctiva
0.689 0.311 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.689 0.311 0.000
H80-H83 Diseases of inner ear
0.689 0.311 0.000
Z38 Liveborn infants according to place of birth
0.689 0.311 0.000
Z32 Pregnancy examination and test
0.689 0.311 0.000
F60-F69 Disorders of adult personality and behaviour
0.689 0.311 0.000
Z73.8 Other problems related to life-management difficulty
0.688 0.312 0.000
Z70 Counselling related to sexual attitude, behaviour and orientation
0.688 0.312 0.000
M54 Dorsalgia
0.688 0.312 0.000
M86 Osteomyelitis
0.685 0.314 0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.685 0.315 0.000
D74 Methaemoglobinaemia
0.685 0.315 0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.685 0.315 0.000
D71 Functional disorders of polymorphonuclear neutrophils
0.685 0.315 0.000
Q80-Q89 Other congenital malformations
0.685 0.315 0.000
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified
0.685 0.315 0.000
Chapter XXII Codes for special purposes
0.684 0.316 0.000
M54.9 Dorsalgia, unspecified
0.683 0.317 0.000
Z57.2 Occupational exposure to dust
0.681 0.318 0.000
Z63.8 Other specified problems related to primary support group
0.681 0.319 0.000
C80 Malignant neoplasm without specification of site
0.680 0.320 0.000
M13.99 Arthritis, unspecified (Site unspecified)
0.678 0.322 0.000
S92 Fracture of foot, except ankle
0.678 0.322 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.677 0.323 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.677 0.323 0.000
M88 Paget's disease of bone [osteitis deformans]
0.677 0.323 0.000
H53.1 Subjective visual disturbances
0.677 0.323 0.000
M19.90 Arthrosis, unspecified (Multiple sites)
0.676 0.324 0.000
C82.7 Other types of follicular non-Hodgkin's lymphoma
0.675 0.325 0.000
Z71.8 Other specified counselling
0.674 0.326 0.000
Z73.3 Stress, not elsewhere classified
0.674 0.326 0.000
M13.0 Polyarthritis, unspecified
0.673 0.327 0.000
A41.9 Septicaemia, unspecified
0.673 0.327 0.000
H90.2 Conductive hearing loss, unspecified
0.672 0.328 0.000
B95.0 Streptococcus, group A, as the cause of diseases classified to other chapters
0.670 0.330 0.000
B95.7 Other staphylococcus as the cause of diseases classified to other chapters
0.669 0.331 0.000
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.669 0.331 0.000
O43 Placental disorders
0.668 0.331 0.000
Z60.9 Problem related to social environment, unspecified
0.668 0.332 0.000
Z60.8 Other problems related to social environment
0.668 0.332 0.000
Z60.5 Target of perceived adverse discrimination and persecution
0.668 0.332 0.000
Z60.4 Social exclusion and rejection
0.668 0.332 0.000
Z60.3 Acculturation difficulty
0.668 0.332 0.000
Z60.1 Atypical parenting situation
0.668 0.332 0.000
Z60.0 Problems of adjustment to life-cycle transitions
0.668 0.332 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.668 0.332 0.000
C15.5 Lower third of oesophagus
0.668 0.332 0.000
Y40.9 Systemic antibiotic, unspecified
0.667 0.333 0.000
H53.2 Diplopia
0.667 0.333 0.000
Z57.3 Occupational exposure to other air contaminants
0.667 0.333 0.000
B25-B34 Other viral diseases
0.667 0.333 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.667 0.333 0.000
Z74.1 Need for assistance with personal care
0.666 0.334 0.000
M87 Osteonecrosis
0.665 0.335 0.000
O99.1 Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
0.665 0.335 0.000
Z40 Prophylactic surgery
0.665 0.335 0.000
M54.99 Dorsalgia, unspecified (Site unspecified)
0.665 0.335 0.000
B37 Candidiasis
0.664 0.336 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.664 0.336 0.000
O45 Premature separation of placenta [abruptio placentae]
0.662 0.338 0.000
O33 Maternal care for known or suspected disproportion
0.662 0.338 0.000
O31 Complications specific to multiple gestation
0.662 0.338 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.662 0.338 0.000
F70-F79 Mental retardation
0.662 0.338 0.000
O99.4 Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
0.661 0.339 0.000
O61 Failed induction of labour
0.661 0.339 0.000
O47 False labour
0.661 0.339 0.000
H91.8 Other specified hearing loss
0.660 0.340 0.000
C15.9 Oesophagus, unspecified
0.660 0.340 0.000
O64 Obstructed labour due to malposition and malpresentation of foetus
0.659 0.341 0.000
O99.6 Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
0.657 0.343 0.000
C83.9 Diffuse non-Hodgkin's lymphoma, unspecified
0.655 0.344 0.000
C83.7 Burkitt's tumour
0.655 0.344 0.000
C83.6 Undifferentiated (diffuse)
0.655 0.344 0.000
C83.5 Lymphoblastic (diffuse)
0.655 0.344 0.000
C83.4 Immunoblastic (diffuse)
0.655 0.344 0.000
C83.2 Mixed small and large cell (diffuse)
0.655 0.344 0.000
Z63.0 Problems in relationship with spouse or partner
0.655 0.345 0.000
C50.5 Lower-outer quadrant of breast
0.654 0.346 0.000
M11.2 Other chondrocalcinosis
0.654 0.346 0.000
F31 Bipolar affective disorder
0.653 0.346 0.000
Z50.6 Orthoptic training
0.652 0.348 0.000
Z50.3 Drug rehabilitation
0.652 0.348 0.000
C64-C68 Malignant neoplasms of urinary tract
0.652 0.348 0.000
Z74.0 Reduced mobility
0.652 0.348 0.000
M80-M85 Disorders of bone density and structure
0.652 0.348 0.000
Q50-Q56 Congenital malformations of genital organs
0.651 0.348 0.000
B97.8 Other viral agents as the cause of diseases classified to other chapters
0.651 0.349 0.000
Z44 Fitting and adjustment of external prosthetic device
0.650 0.349 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.651 0.349 0.000
O00-O08 Pregnancy with abortive outcome
0.650 0.350 0.000
M13.8 Other specified arthritis
0.649 0.350 0.000
O30.0 Twin pregnancy
0.647 0.353 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.647 0.353 0.000
V20-V29 Motorcycle rider injured in transport accident
0.646 0.353 0.000
H90.5 Sensorineural hearing loss, unspecified
0.647 0.353 0.000
C83.0 Small cell (diffuse)
0.646 0.354 0.000
D06 Carcinoma in situ of cervix uteri
0.646 0.354 0.000
C81.9 Hodgkin's disease, unspecified
0.645 0.355 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.643 0.357 0.000
C85.7 Other specified types of non-Hodgkin's lymphoma
0.643 0.357 0.000
C85.2 Mediastinal (thymic) large B-cell lymphoma
0.643 0.357 0.000
C85.0 Lymphosarcoma
0.643 0.357 0.000
Y52.9 Other and unspecified agents primarily affecting the cardiovascular system
0.643 0.357 0.000
Y52.8 Antivaricose drugs, including sclerosing agents
0.643 0.357 0.000
Y52.7 Peripheral vasodilators
0.643 0.357 0.000
Y52.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.643 0.357 0.000
Y52.1 Calcium-channel blockers
0.643 0.357 0.000
Y52.0 Cardiac-stimulant glycosides and drugs of similar action
0.643 0.357 0.000
H93 Other disorders of ear, not elsewhere classified
0.642 0.358 0.000
O48 Prolonged pregnancy
0.642 0.358 0.000
Z57.5 Occupational exposure to toxic agents in other industries
0.642 0.358 0.000
H55-H59 Other disorders of eye and adnexa
0.642 0.358 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.642 0.358 0.000
Z73.9 Problem related to life-management difficulty, unspecified
0.640 0.359 0.000
Z54 Convalescence
0.640 0.360 0.000
M89.97 Disorder of bone, unspecified (Ankle and foot)
0.639 0.361 0.000
S60-S69 Injuries to the wrist and hand
0.639 0.361 0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases
0.639 0.361 0.000
A87 Viral meningitis
0.638 0.361 0.000
Q60-Q64 Congenital malformations of the urinary system
0.638 0.362 0.000
B15-B19 Viral hepatitis
0.638 0.362 0.000
O98 Maternal infectious and parasitic diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
0.636 0.364 0.000
O97 Death from sequelae of direct obstetric causes
0.636 0.364 0.000
O96 Death from any obstetric cause occurring more than 42 days but less than one year after delivery
0.636 0.364 0.000
O95 Obstetric death of unspecified cause
0.636 0.364 0.000
O94 Sequelae of complication of pregnancy, childbirth and the puerperium
0.636 0.364 0.000
F99-F99 Unspecified mental disorder
0.635 0.365 0.000
M62 Other disorders of muscle
0.634 0.366 0.000
X49 Accidental poisoning by and exposure to other and unspecified chemicals and noxious substances
0.634 0.366 0.000
M19.09 Primary arthrosis of other joints (Site unspecified)
0.634 0.366 0.000
O14 Gestational [pregnancy-induced] hypertension with significant proteinuria
0.634 0.366 0.000
D69 Purpura and other haemorrhagic conditions
0.631 0.369 0.000
A46 Erysipelas
0.631 0.369 0.000
O13 Gestational [pregnancy-induced] hypertension without significant proteinuria
0.629 0.371 0.000
Z42 Follow-up care involving plastic surgery
0.629 0.371 0.000
Z50.7 Occupational therapy and vocational rehabilitation, not elsewhere classified
0.629 0.371 0.000
C07 Malignant neoplasm of parotid gland
0.627 0.372 0.000
C50.6 Axillary tail of breast
0.627 0.373 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.627 0.373 0.000
C23 Malignant neoplasm of gallbladder
0.627 0.373 0.000
H95 Postprocedural disorders of ear and mastoid process, not elsewhere classified
0.627 0.373 0.000
H94 Other disorders of ear in diseases classified elsewhere
0.627 0.373 0.000
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites
0.627 0.373 0.000
W25 Contact with sharp glass
0.626 0.374 0.000
O41 Other disorders of amniotic fluid and membranes
0.626 0.374 0.000
O34.7 Maternal care for abnormality of vulva and perineum
0.626 0.374 0.000
Z36 Antenatal screening
0.625 0.374 0.000
F43 Reaction to severe stress, and adjustment disorders
0.625 0.375 0.000
M54.96 Dorsalgia, unspecified (Lumbar region)
0.625 0.375 0.000
M90.7 Fracture of bone in neoplastic disease
0.625 0.375 0.000
H25-H28 Disorders of lens
0.624 0.376 0.000
A00-A09 Intestinal infectious diseases
0.624 0.376 0.000
S92.0 Fracture of calcaneus
0.624 0.376 0.000
O32 Maternal care for known or suspected malpresentation of foetus
0.622 0.377 0.000
F12.1 Harmful use
0.622 0.378 0.000
Z50.5 Speech therapy
0.622 0.378 0.000
M21 Other acquired deformities of limbs
0.622 0.378 0.000
M19.99 Arthrosis, unspecified (Site unspecified)
0.622 0.378 0.000
C88.0 Waldenstrom's macroglobulinaemia
0.621 0.378 0.000
M07 Psoriatic and enteropathic arthropathies
0.620 0.380 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.619 0.380 0.000
M19.08 Primary arthrosis of other joints (Other)
0.619 0.381 0.000
M19.06 Primary arthrosis of other joints-Lower leg
0.619 0.381 0.000
M19.05 Primary arthrosis of other joints (Pelvic region and thigh)
0.619 0.381 0.000
M19.03 Primary arthrosis of other joints (Forearm)
0.619 0.381 0.000
M19.02 Primary arthrosis of other joints (Upper arm)
0.619 0.381 0.000
M19.00 Primary arthrosis of other joints (Multiple sites)
0.619 0.381 0.000
D73.0 Hyposplenism
0.619 0.381 0.000
Z71.6 Tobacco abuse counselling
0.618 0.382 0.000
M89.8 Other specified disorders of bone
0.618 0.382 0.000
C49 Malignant neoplasm of other connective and soft tissue
0.618 0.382 0.000
O74 Complications of anaesthesia during labour and delivery
0.618 0.382 0.000
O71 Other obstetric trauma
0.618 0.382 0.000
O65 Obstructed labour due to maternal pelvic abnormality
0.618 0.382 0.000
O60 Preterm delivery
0.618 0.382 0.000
Z52 Donors of organs and tissues
0.617 0.383 0.000
C04 Malignant neoplasm of floor of mouth
0.617 0.383 0.000
S70-S79 Injuries to the hip and thigh
0.617 0.383 0.000
X62 Intentional self-poisoning by and exposure to narcotics and psychodysleptics [hallucinogens], not elsewhere classified
0.616 0.384 0.000
Y52.4 Angiotensin-converting-enzyme inhibitors
0.616 0.384 0.000
M19.97 Arthrosis, unspecified (Ankle and foot)
0.616 0.384 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.616 0.384 0.000
B95.2 Streptococcus, group D, as the cause of diseases classified to other chapters
0.614 0.386 0.000
M13.97 Arthritis, unspecified (Ankle and foot)
0.614 0.386 0.000
M06.8 Other specified rheumatoid arthritis
0.613 0.387 0.000
M06.4 Inflammatory polyarthropathy
0.613 0.387 0.000
M06.2 Rheumatoid bursitis
0.613 0.387 0.000
M06.1 Adult-onset Still's disease
0.613 0.387 0.000
C48 Malignant neoplasm of retroperitoneum and peritoneum
0.612 0.387 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.612 0.388 0.000
C01 Malignant neoplasm of base of tongue
0.611 0.389 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.611 0.389 0.000
W19 Unspecified fall
0.611 0.389 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.611 0.389 0.000
Z63.9 Problem related to primary support group, unspecified
0.610 0.390 0.000
Z63.7 Other stressful life events affecting family and household
0.610 0.390 0.000
Z63.6 Dependent relative needing care at home
0.610 0.390 0.000
Z63.3 Absence of family member
0.610 0.390 0.000
Z63.2 Inadequate family support
0.610 0.390 0.000
Z63.1 Problems in relationship with parents and in-laws
0.610 0.390 0.000
H92 Otalgia and effusion of ear
0.609 0.391 0.000
M19.19 Post-traumatic arthrosis of other joints (Site unspecified)
0.609 0.391 0.000
M19.18 Post-traumatic arthrosis of other joints (Other)
0.609 0.391 0.000
M19.16 Post-traumatic arthrosis of other joints-Lower leg
0.609 0.391 0.000
M19.15 Post-traumatic arthrosis of other joints (Pelvic region and thigh)
0.609 0.391 0.000
M19.14 Post-traumatic arthrosis of other joints (Hand)
0.609 0.391 0.000
M19.13 Post-traumatic arthrosis of other joints (Forearm)
0.609 0.391 0.000
M19.12 Post-traumatic arthrosis of other joints (Upper arm)
0.609 0.391 0.000
M19.11 Post-traumatic arthrosis of other joints (Shoulder region)
0.609 0.391 0.000
M19.10 Post-traumatic arthrosis of other joints (Multiple sites)
0.609 0.391 0.000
Z74.9 Problem related to care-provider dependency, unspecified
0.609 0.391 0.000
Z74.8 Other problems related to care-provider dependency
0.609 0.391 0.000
Z74.3 Need for continuous supervision
0.609 0.391 0.000
O75.7 Vaginal delivery following previous Caesarean section
0.608 0.392 0.000
M65 Synovitis and tenosynovitis
0.608 0.392 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.607 0.393 0.000
C90 Multiple myeloma and malignant plasma cell neoplasms
0.607 0.393 0.000
C25 Malignant neoplasm of pancreas
0.607 0.393 0.000
F17.2 Dependence syndrome
0.606 0.394 0.000
V10-V19 Pedal cyclist injured in transport accident
0.606 0.394 0.000
T66-T78 Other and unspecified effects of external causes
0.606 0.394 0.000
Y40.7 Antifungal antibiotics, systemically used
0.606 0.394 0.000
Y40.6 Rifamycins
0.606 0.394 0.000
Y40.5 Aminoglycosides
0.606 0.394 0.000
Y40.4 Tetracyclines
0.606 0.394 0.000
Y40.3 Macrolides
0.606 0.394 0.000
Y40.2 Chloramphenicol group
0.606 0.394 0.000
Y40.1 Cefalosporins and other -lactam antibiotics
0.606 0.394 0.000
Z71.3 Dietary counselling and surveillance
0.605 0.395 0.000
Z34.0 Supervision of normal first pregnancy
0.605 0.395 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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