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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs45461993
log Bayes Factor = 5.77094
Chromosome 20   position 61,983,901  (GRCh37) Explore rs45461993 on Ensembl!
Variant rs45461993 is part of Cluster X0322

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
J44.9 Chronic obstructive pulmonary disease, unspecified
1.000 0.000 0.000
J44 Other chronic obstructive pulmonary disease
0.997 0.003 0.000
I20.0 Unstable angina
0.997 0.003 0.000
I20 Angina pectoris
0.997 0.003 0.000
I20-I25 Ischaemic heart diseases
0.996 0.004 0.000
J40-J47 Chronic lower respiratory diseases
0.989 0.011 0.000
I25 Chronic ischaemic heart disease
0.985 0.015 0.000
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection
0.974 0.026 0.000
J43 Emphysema
0.972 0.028 0.000
I25.1 Atherosclerotic heart disease
0.968 0.032 0.000
Chapter IX Diseases of the circulatory system
0.965 0.035 0.000
J43.9 Emphysema, unspecified
0.959 0.041 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.947 0.053 0.000
I60-I69 Cerebrovascular diseases
0.943 0.057 0.000
J47 Bronchiectasis
0.942 0.058 0.000
I24 Other acute ischaemic heart diseases
0.929 0.071 0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.899 0.101 0.000
I69 Sequelae of cerebrovascular disease
0.896 0.104 0.000
I20.9 Angina pectoris, unspecified
0.894 0.106 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.892 0.108 0.000
I24.9 Acute ischaemic heart disease, unspecified
0.879 0.121 0.000
I69.3 Sequelae of cerebral infarction
0.878 0.122 0.000
I65.2 Occlusion and stenosis of carotid artery
0.868 0.132 0.000
I77 Other disorders of arteries and arterioles
0.859 0.141 0.000
I60 Subarachnoid haemorrhage
0.855 0.145 0.000
I25.5 Ischaemic cardiomyopathy
0.846 0.154 0.000
I25.8 Other forms of chronic ischaemic heart disease
0.838 0.162 0.000
I20.1 Angina pectoris with documented spasm
0.833 0.167 0.000
J42 Unspecified chronic bronchitis
0.830 0.170 0.000
I98 Other disorders of circulatory system in diseases classified elsewhere
0.830 0.170 0.000
I70 Atherosclerosis
0.818 0.182 0.000
I71 Aortic aneurysm and dissection
0.816 0.184 0.000
I62 Other nontraumatic intracranial haemorrhage
0.792 0.208 0.000
I77.6 Arteritis, unspecified
0.778 0.222 0.000
I25.4 Coronary artery aneurysm
0.774 0.226 0.000
I73 Other peripheral vascular diseases
0.770 0.230 0.000
I78 Diseases of capillaries
0.769 0.231 0.000
I99 Other and unspecified disorders of circulatory system
0.763 0.237 0.000
I98.2 Oesophageal varices in diseases classified elsewhere
0.756 0.244 0.000
J40 Bronchitis, not specified as acute or chronic
0.755 0.245 0.000
I24.8 Other forms of acute ischaemic heart disease
0.754 0.246 0.000
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.754 0.246 0.000
I22 Subsequent myocardial infarction
0.751 0.249 0.000
I72 Other aneurysm
0.739 0.261 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.727 0.272 0.000
I23 Certain current complications following acute myocardial infarction
0.725 0.274 0.000
I60.9 Subarachnoid haemorrhage, unspecified
0.716 0.284 0.000
J46 Status asthmaticus
0.715 0.285 0.000
I77.1 Stricture of artery
0.714 0.286 0.000
I25.9 Chronic ischaemic heart disease, unspecified
0.712 0.288 0.000
I71.0 Dissection of aorta [any part]
0.712 0.288 0.000
J43.2 Centrilobular emphysema
0.710 0.290 0.000
J41 Simple and mucopurulent chronic bronchitis
0.709 0.291 0.000
I24.1 Dressler's syndrome
0.708 0.292 0.000
I25.6 Silent myocardial ischaemia
0.706 0.293 0.000
I60.2 Subarachnoid haemorrhage from anterior communicating artery
0.698 0.301 0.000
J43.8 Other emphysema
0.697 0.303 0.000
J43.1 Panlobular emphysema
0.697 0.303 0.000
J43.0 MacLeod's syndrome
0.697 0.303 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.697 0.303 0.000
I73.9 Peripheral vascular disease, unspecified
0.695 0.305 0.000
I00-I02 Acute rheumatic fever
0.692 0.308 0.000
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere
0.689 0.311 0.000
I60.8 Other subarachnoid haemorrhage
0.683 0.317 0.000
I70.2 Atherosclerosis of arteries of the extremities
0.682 0.318 0.000
I69.1 Sequelae of intracerebral haemorrhage
0.677 0.323 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.676 0.324 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.676 0.324 0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.662 0.337 0.000
I69.8 Sequelae of other and unspecified cerebrovascular diseases
0.659 0.341 0.000
I73.8 Other specified peripheral vascular diseases
0.653 0.347 0.000
I70.0 Atherosclerosis of aorta
0.647 0.353 0.000
I27 Other pulmonary heart diseases
0.646 0.354 0.000
I65.9 Occlusion and stenosis of unspecified precerebral artery
0.645 0.355 0.000
I65.8 Occlusion and stenosis of other precerebral artery
0.645 0.355 0.000
I65.3 Occlusion and stenosis of multiple and bilateral precerebral arteries
0.645 0.355 0.000
I65.1 Occlusion and stenosis of basilar artery
0.645 0.355 0.000
I65.0 Occlusion and stenosis of vertebral artery
0.645 0.355 0.000
I62.9 Intracranial haemorrhage (nontraumatic), unspecified
0.643 0.357 0.000
I78.0 Hereditary haemorrhagic telangiectasia
0.643 0.357 0.000
I69.2 Sequelae of other nontraumatic intracranial haemorrhage
0.642 0.358 0.000
I60.3 Subarachnoid haemorrhage from posterior communicating artery
0.640 0.360 0.000
I62.0 Subdural haemorrhage (acute) (nontraumatic)
0.630 0.370 0.000
J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified
0.630 0.370 0.000
I97.8 Other postprocedural disorders of circulatory system, not elsewhere classified
0.625 0.375 0.000
I25.3 Aneurysm of heart
0.623 0.377 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.622 0.378 0.000
I72.3 Aneurysm of iliac artery
0.621 0.379 0.000
I72.8 Aneurysm of other specified arteries
0.621 0.379 0.000
I77.9 Disorder of arteries and arterioles, unspecified
0.619 0.381 0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.619 0.381 0.000
I77.5 Necrosis of artery
0.616 0.384 0.000
I77.4 Coeliac artery compression syndrome
0.616 0.384 0.000
I77.3 Arterial fibromuscular dysplasia
0.616 0.384 0.000
I77.2 Rupture of artery
0.616 0.384 0.000
I60.7 Subarachnoid haemorrhage from intracranial artery, unspecified
0.613 0.387 0.000
I60.6 Subarachnoid haemorrhage from other intracranial arteries
0.613 0.387 0.000
I60.5 Subarachnoid haemorrhage from vertebral artery
0.613 0.387 0.000
I60.4 Subarachnoid haemorrhage from basilar artery
0.613 0.387 0.000
I60.0 Subarachnoid haemorrhage from carotid siphon and bifurcation
0.613 0.387 0.000
I22.1 Subsequent myocardial infarction of inferior wall
0.609 0.391 0.000
I70.1 Atherosclerosis of renal artery
0.602 0.398 0.000
I98.8 Other specified disorders of circulatory system in diseases classified elsewhere
0.595 0.405 0.000
I98.1 Cardiovascular disorders in other infectious and parasitic diseases classified elsewhere
0.595 0.405 0.000
I98.0 Cardiovascular syphilis
0.595 0.405 0.000
I97.2 Postmastectomy lymphoedema syndrome
0.589 0.411 0.000
I60.1 Subarachnoid haemorrhage from middle cerebral artery
0.586 0.413 0.000
I70.9 Generalised and unspecified atherosclerosis
0.586 0.414 0.000
I70.8 Atherosclerosis of other arteries
0.586 0.414 0.000
I27.9 Pulmonary heart disease, unspecified
0.586 0.414 0.000
I71.8 Aortic aneurysm of unspecified site, ruptured
0.585 0.415 0.000
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.585 0.415 0.000
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.585 0.415 0.000
I71.1 Thoracic aortic aneurysm, ruptured
0.585 0.415 0.000
I70.20 Atherosclerosis of arteries of extremities (without gangrene)
0.585 0.415 0.000
I77.8 Other specified disorders of arteries and arterioles
0.582 0.417 0.000
I77.0 Arteriovenous fistula, acquired
0.575 0.425 0.000
I22.8 Subsequent myocardial infarction of other sites
0.569 0.430 0.000
I62.1 Nontraumatic extradural haemorrhage
0.568 0.432 0.000
I78.1 Naevus, nonneoplastic
0.567 0.433 0.000
I74 Arterial embolism and thrombosis
0.566 0.433 0.000
I73.1 Thromboangiitis obliterans [Buerger]
0.552 0.448 0.000
I78.9 Disease of capillaries, unspecified
0.552 0.448 0.000
I71.3 Abdominal aortic aneurysm, ruptured
0.549 0.451 0.000
I97.9 Postprocedural disorder of circulatory system, unspecified
0.540 0.460 0.000
I97.1 Other functional disturbances following cardiac surgery
0.540 0.460 0.000
I97.0 Postcardiotomy syndrome
0.540 0.460 0.000
I27.2 Other secondary pulmonary hypertension
0.537 0.463 0.000
I64 Stroke, not specified as haemorrhage or infarction
0.536 0.464 0.000
I22.0 Subsequent myocardial infarction of anterior wall
0.535 0.465 0.000
I78.8 Other diseases of capillaries
0.533 0.467 0.000
I23.8 Other current complications following acute myocardial infarction
0.531 0.468 0.000
I72.9 Aneurysm of unspecified site
0.530 0.470 0.000
I72.6 Aneurysm and dissection of vertebral artery
0.530 0.470 0.000
I72.5 Aneurysm and dissection of other precerebral arteries
0.530 0.470 0.000
I72.2 Aneurysm of renal artery
0.530 0.470 0.000
I72.1 Aneurysm of artery of upper extremity
0.530 0.470 0.000
I70.00 Atherosclerosis of aorta (without gangrene)
0.525 0.475 0.000
I25.2 Old myocardial infarction
0.523 0.477 0.000
I28 Other diseases of pulmonary vessels
0.522 0.478 0.000
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.520 0.480 0.000
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.520 0.480 0.000
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.520 0.480 0.000
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.520 0.480 0.000
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.520 0.480 0.000
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.520 0.480 0.000
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.520 0.480 0.000
Chapter X Diseases of the respiratory system
0.516 0.484 0.000
I69.0 Sequelae of subarachnoid haemorrhage
0.515 0.485 0.000
I61 Intracerebral haemorrhage
0.512 0.487 0.000
J41.8 Mixed simple and mucopurulent chronic bronchitis
0.508 0.491 0.000
J41.1 Mucopurulent chronic bronchitis
0.508 0.491 0.000
J41.0 Simple chronic bronchitis
0.508 0.491 0.000
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction
0.504 0.496 0.000
I05-I09 Chronic rheumatic heart diseases
0.502 0.498 0.000
I02 Rheumatic chorea
0.496 0.504 0.000
I01 Rheumatic fever with heart involvement
0.496 0.504 0.000
I00 Rheumatic fever without mention of heart involvement
0.496 0.504 0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.495 0.504 0.000
I70.21 Atherosclerosis of arteries of extremities (with gangrene)
0.489 0.511 0.000
J09-J18 Influenza and pneumonia
0.487 0.513 0.000
I66.9 Occlusion and stenosis of unspecified cerebral artery
0.485 0.515 0.000
I66.8 Occlusion and stenosis of other cerebral artery
0.485 0.515 0.000
I66.4 Occlusion and stenosis of multiple and bilateral cerebral arteries
0.485 0.515 0.000
I66.3 Occlusion and stenosis of cerebellar arteries
0.485 0.515 0.000
I66.2 Occlusion and stenosis of posterior cerebral artery
0.485 0.515 0.000
I66.1 Occlusion and stenosis of anterior cerebral artery
0.485 0.515 0.000
I66.0 Occlusion and stenosis of middle cerebral artery
0.485 0.515 0.000
I68.8 Other cerebrovascular disorders in diseases classified elsewhere
0.485 0.515 0.000
I68.2 Cerebral arteritis in other diseases classified elsewhere
0.485 0.515 0.000
I68.1 Cerebral arteritis in infectious and parasitic diseases classified elsewhere
0.485 0.515 0.000
I68.0 Cerebral amyloid angiopathy
0.485 0.515 0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.476 0.524 0.000
F17.1 Harmful use
0.469 0.531 0.000
I74.5 Embolism and thrombosis of iliac artery
0.467 0.533 0.000
I70.01 Atherosclerosis of aorta (with gangrene)
0.464 0.536 0.000
I27.1 Kyphoscoliotic heart disease
0.463 0.536 0.000
I27.8 Other specified pulmonary heart diseases
0.461 0.539 0.000
J13 Pneumonia due to Streptococcus pneumoniae
0.456 0.544 0.000
F17 Mental and behavioural disorders due to use of tobacco
0.451 0.549 0.000
I70.10 Atherosclerosis of renal artery (without gangrene)
0.448 0.552 0.000
I22.9 Subsequent myocardial infarction of unspecified site
0.447 0.553 0.000
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.446 0.554 0.000
I79.1 Aortitis in diseases classified elsewhere
0.446 0.554 0.000
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.446 0.554 0.000
J44.8 Other specified chronic obstructive pulmonary disease
0.445 0.555 0.000
I72.4 Aneurysm of artery of lower extremity
0.444 0.556 0.000
I21 Acute myocardial infarction
0.441 0.559 0.000
I70.11 Atherosclerosis of renal artery (with gangrene)
0.432 0.568 0.000
I63 Cerebral infarction
0.425 0.575 0.000
J00-J06 Acute upper respiratory infections
0.425 0.575 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.424 0.576 0.000
I74.9 Embolism and thrombosis of unspecified artery
0.422 0.577 0.000
I70.81 Atherosclerosis of other arteries (with gangrene)
0.420 0.579 0.000
I70.80 Atherosclerosis of other arteries (without gangrene)
0.420 0.579 0.000
I70.91 Generalized and unspecified atherosclerosis (with gangrene)
0.420 0.579 0.000
I70.90 Generalized and unspecified atherosclerosis (without gangrene)
0.420 0.579 0.000
Chapter V Mental and behavioural disorders
0.419 0.581 0.000
J14 Pneumonia due to Haemophilus influenzae
0.415 0.585 0.000
# Top node
0.413 0.587 0.000
I61.3 Intracerebral haemorrhage in brain stem
0.408 0.591 0.000
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.406 0.594 0.000
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.406 0.594 0.000
I74.0 Embolism and thrombosis of abdominal aorta
0.406 0.594 0.000
J10 Influenza due to identified influenza virus
0.406 0.594 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.403 0.597 0.000
I72.0 Aneurysm of carotid artery
0.402 0.597 0.000
I61.1 Intracerebral haemorrhage in hemisphere, cortical
0.402 0.598 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.401 0.599 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.401 0.599 0.000
I21.9 Acute myocardial infarction, unspecified
0.399 0.601 0.000
J15 Bacterial pneumonia, not elsewhere classified
0.397 0.603 0.000
O60-O75 Complications of labour and delivery
0.394 0.606 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.392 0.608 0.000
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.388 0.611 0.000
F20 Schizophrenia
0.388 0.612 0.000
J00 Acute nasopharyngitis [common cold]
0.387 0.613 0.000
F17.2 Dependence syndrome
0.384 0.616 0.000
I74.8 Embolism and thrombosis of other arteries
0.383 0.617 0.000
I28.9 Disease of pulmonary vessels, unspecified
0.374 0.626 0.000
I28.8 Other specified diseases of pulmonary vessels
0.374 0.626 0.000
I28.1 Aneurysm of pulmonary artery
0.374 0.626 0.000
I28.0 Arteriovenous fistula of pulmonary vessels
0.374 0.626 0.000
I61.0 Intracerebral haemorrhage in hemisphere, subcortical
0.374 0.626 0.000
I63.4 Cerebral infarction due to embolism of cerebral arteries
0.373 0.627 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.372 0.628 0.000
O13 Gestational [pregnancy-induced] hypertension without significant proteinuria
0.369 0.631 0.000
I61.6 Intracerebral haemorrhage, multiple localised
0.367 0.632 0.000
I61.2 Intracerebral haemorrhage in hemisphere, unspecified
0.367 0.632 0.000
I08 Multiple valve diseases
0.367 0.633 0.000
I09 Other rheumatic heart diseases
0.366 0.634 0.000
O70 Perineal laceration during delivery
0.362 0.638 0.000
F20.0 Paranoid schizophrenia
0.362 0.638 0.000
I06 Rheumatic aortic valve diseases
0.360 0.640 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.356 0.644 0.000
I01.9 Acute rheumatic heart disease, unspecified
0.356 0.644 0.000
I01.8 Other acute rheumatic heart disease
0.356 0.644 0.000
I01.2 Acute rheumatic myocarditis
0.356 0.644 0.000
I01.1 Acute rheumatic endocarditis
0.356 0.644 0.000
I01.0 Acute rheumatic pericarditis
0.356 0.644 0.000
I02.9 Rheumatic chorea without heart involvement
0.356 0.644 0.000
I02.0 Rheumatic chorea with heart involvement
0.356 0.644 0.000
I27.0 Primary pulmonary hypertension
0.355 0.644 0.000
O70.0 First degree perineal laceration during delivery
0.354 0.646 0.000
O85-O92 Complications predominantly related to the puerperium
0.350 0.650 0.000
Chapter XX External causes of morbidity and mortality
0.349 0.651 0.000
J16 Pneumonia due to other infectious organisms, not elsewhere classified
0.349 0.651 0.000
J12 Viral pneumonia, not elsewhere classified
0.349 0.651 0.000
J09 Influenza due to certain identified influenza virus
0.349 0.651 0.000
I61.4 Intracerebral haemorrhage in cerebellum
0.348 0.652 0.000
J80 Adult respiratory distress syndrome
0.344 0.656 0.000
O12 Gestational [pregnancy-induced] oedema and proteinuria without hypertension
0.340 0.660 0.000
F11 Mental and behavioural disorders due to use of opioids
0.340 0.660 0.000
J02 Acute pharyngitis
0.339 0.661 0.000
O71 Other obstetric trauma
0.338 0.662 0.000
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.335 0.664 0.000
I61.5 Intracerebral haemorrhage, intraventricular
0.334 0.666 0.000
J10.0 Influenza with pneumonia, influenza virus identified
0.334 0.666 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.331 0.669 0.000
F19 Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances
0.329 0.671 0.000
J17 Pneumonia in diseases classified elsewhere
0.329 0.671 0.000
I63.2 Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
0.328 0.671 0.000
J15.2 Pneumonia due to staphylococcus
0.328 0.672 0.000
O62 Abnormalities of forces of labour
0.327 0.673 0.000
F60-F69 Disorders of adult personality and behaviour
0.327 0.673 0.000
F20.9 Schizophrenia, unspecified
0.326 0.674 0.000
F99-F99 Unspecified mental disorder
0.325 0.674 0.000
F22 Persistent delusional disorders
0.325 0.675 0.000
J15.4 Pneumonia due to other streptococci
0.323 0.676 0.000
F25 Schizoaffective disorders
0.323 0.676 0.000
F17.9 Unspecified mental and behavioural disorder
0.323 0.677 0.000
F17.8 Other mental and behavioural disorders
0.323 0.677 0.000
F17.7 Residual and late-onset psychotic disorder
0.323 0.677 0.000
F17.6 Amnesic syndrome
0.323 0.677 0.000
F17.5 Psychotic disorder
0.323 0.677 0.000
F17.4 Withdrawal state with delirium
0.323 0.677 0.000
F17.3 Withdrawal state
0.323 0.677 0.000
F17.0 Acute intoxication
0.323 0.677 0.000
O14 Gestational [pregnancy-induced] hypertension with significant proteinuria
0.322 0.678 0.000
I08.2 Disorders of both aortic and tricuspid valves
0.322 0.678 0.000
I61.8 Other intracerebral haemorrhage
0.321 0.679 0.000
I67 Other cerebrovascular diseases
0.321 0.679 0.000
O68 Labour and delivery complicated by foetal stress [distress]
0.320 0.680 0.000
O64 Obstructed labour due to malposition and malpresentation of foetus
0.320 0.680 0.000
O75 Other complications of labour and delivery, not elsewhere classified
0.316 0.684 0.000
I21.X Presumed acute myicardial infaction (unconfirmed)
0.316 0.684 0.000
F20.5 Residual schizophrenia
0.316 0.684 0.000
Y95 Nosocomial condition
0.315 0.685 0.000
F70-F79 Mental retardation
0.315 0.685 0.000
J05 Acute obstructive laryngitis [croup] and epiglottitis
0.315 0.685 0.000
J10.1 Influenza with other respiratory manifestations, influenza virus identified
0.313 0.687 0.000
J84 Other interstitial pulmonary diseases
0.312 0.688 0.000
I10-I15 Hypertensive diseases
0.310 0.690 0.000
Q80-Q89 Other congenital malformations
0.310 0.690 0.000
O66 Other obstructed labour
0.308 0.692 0.000
Q60-Q64 Congenital malformations of the urinary system
0.308 0.692 0.000
I63.6 Cerebral infarction due to cerebral venous thrombosis, nonpyogenic
0.305 0.695 0.000
I63.1 Cerebral infarction due to embolism of precerebral arteries
0.305 0.695 0.000
I63.0 Cerebral infarction due to thrombosis of precerebral arteries
0.305 0.695 0.000
F18 Mental and behavioural disorders due to use of volatile solvents
0.304 0.696 0.000
F16 Mental and behavioural disorders due to use of hallucinogens
0.304 0.696 0.000
F15 Mental and behavioural disorders due to use of other stimulants, including caffeine
0.304 0.696 0.000
F14 Mental and behavioural disorders due to use of cocaine
0.304 0.696 0.000
F13 Mental and behavioural disorders due to use of sedatives or hypnotics
0.304 0.696 0.000
O12.0 Gestational oedema
0.303 0.697 0.000
O69 Labour and delivery complicated by umbilical cord complications
0.303 0.697 0.000
I21.3 Acute transmural myocardial infarction of unspecified site
0.303 0.697 0.000
J60-J70 Lung diseases due to external agents
0.301 0.699 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.300 0.700 0.000
F80-F89 Disorders of psychological development
0.299 0.701 0.000
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified
0.299 0.701 0.000
I21.4 Acute subendocardial myocardial infarction
0.298 0.702 0.000
J11 Influenza, virus not identified
0.298 0.702 0.000
O68.1 Labour and delivery complicated by meconium in amniotic fluid
0.297 0.703 0.000
I26 Pulmonary embolism
0.297 0.703 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.297 0.703 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.296 0.704 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.296 0.704 0.000
I30-I52 Other forms of heart disease
0.294 0.706 0.000
O65 Obstructed labour due to maternal pelvic abnormality
0.294 0.706 0.000
O68.9 Labour and delivery complicated by foetal stress, unspecified
0.292 0.708 0.000
J10.8 Influenza with other manifestations, influenza virus identified
0.291 0.709 0.000
I42 Cardiomyopathy
0.289 0.711 0.000
W50-W64 Exposure to animate mechanical forces
0.289 0.711 0.000
J82 Pulmonary eosinophilia, not elsewhere classified
0.289 0.711 0.000
W20-W49 Exposure to inanimate mechanical forces
0.289 0.711 0.000
F28 Other nonorganic psychotic disorders
0.288 0.712 0.000
F24 Induced delusional disorder
0.288 0.712 0.000
F21 Schizotypal disorder
0.288 0.712 0.000
Q61 Cystic kidney disease
0.287 0.713 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.287 0.713 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.286 0.714 0.000
J15.1 Pneumonia due to Pseudomonas
0.286 0.714 0.000
J15.9 Bacterial pneumonia, unspecified
0.285 0.715 0.000
J15.8 Other bacterial pneumonia
0.285 0.715 0.000
J15.6 Pneumonia due to other aerobic Gram-negative bacteria
0.285 0.715 0.000
J15.5 Pneumonia due to Escherichia coli
0.285 0.715 0.000
J15.3 Pneumonia due to streptococcus, group B
0.285 0.715 0.000
O14.9 Preeclampsia, unspecified
0.285 0.715 0.000
I35 Nonrheumatic aortic valve disorders
0.284 0.716 0.000
I42.9 Cardiomyopathy, unspecified
0.284 0.716 0.000
O74 Complications of anaesthesia during labour and delivery
0.283 0.717 0.000
O60 Preterm delivery
0.283 0.717 0.000
J95-J99 Other diseases of the respiratory system
0.282 0.718 0.000
O87 Venous complications in the puerperium
0.281 0.719 0.000
O15 Eclampsia
0.281 0.719 0.000
O11 Pre-existing hypertensive disorder with superimposed proteinuria
0.281 0.719 0.000
O71.4 Obstetric high vaginal laceration alone
0.280 0.720 0.000
F11.2 Dependence syndrome
0.280 0.720 0.000
O90 Complications of the puerperium, not elsewhere classified
0.279 0.721 0.000
Y00-Y09 Assault
0.279 0.721 0.000
J03 Acute tonsillitis
0.279 0.721 0.000
W00-W19 Falls
0.279 0.721 0.000
F20.8 Other schizophrenia
0.278 0.721 0.000
F20.6 Simple schizophrenia
0.278 0.721 0.000
F20.4 Postschizophrenic depression
0.278 0.721 0.000
F20.3 Undifferentiated schizophrenia
0.278 0.721 0.000
F20.2 Catatonic schizophrenia
0.278 0.721 0.000
F20.1 Hebephrenic schizophrenia
0.278 0.721 0.000
J15.7 Pneumonia due to Mycoplasma pneumoniae
0.278 0.722 0.000
O62.1 Secondary uterine inertia
0.278 0.722 0.000
J02.9 Acute pharyngitis, unspecified
0.277 0.723 0.000
J85 Abscess of lung and mediastinum
0.277 0.723 0.000
W75-W84 Other accidental threats to breathing
0.277 0.723 0.000
I07 Rheumatic tricuspid valve diseases
0.276 0.724 0.000
O10 Pre-existing hypertension complicating pregnancy, childbirth and the puerperium
0.276 0.724 0.000
J01 Acute sinusitis
0.275 0.725 0.000
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.275 0.725 0.000
I05 Rheumatic mitral valve diseases
0.273 0.726 0.000
V01-V09 Pedestrian injured in transport accident
0.273 0.727 0.000
O71.7 Obstetric haematoma of pelvis
0.272 0.728 0.000
O86 Other puerperal infections
0.271 0.728 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.271 0.729 0.000
O64.0 Obstructed labour due to incomplete rotation of foetal head
0.271 0.729 0.000
F22.0 Delusional disorder
0.270 0.730 0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.270 0.730 0.000
I21.1 Acute transmural myocardial infarction of inferior wall
0.270 0.730 0.000
I35.0 Aortic (valve) stenosis
0.270 0.730 0.000
I08.0 Disorders of both mitral and aortic valves
0.269 0.730 0.000
I09.9 Rheumatic heart disease, unspecified
0.268 0.731 0.000
I63.3 Cerebral infarction due to thrombosis of cerebral arteries
0.267 0.732 0.000
I63.8 Other cerebral infarction
0.267 0.732 0.000
Q00-Q07 Congenital malformations of the nervous system
0.267 0.733 0.000
J04 Acute laryngitis and tracheitis
0.266 0.734 0.000
J06 Acute upper respiratory infections of multiple and unspecified sites
0.265 0.735 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.265 0.735 0.000
O75.8 Other specified complications of labour and delivery
0.265 0.735 0.000
V40-V49 Car occupant injured in transport accident
0.264 0.736 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.264 0.736 0.000
Chapter XXII Codes for special purposes
0.263 0.737 0.000
I08.9 Multiple valve disease, unspecified
0.263 0.737 0.000
Q61.3 Polycystic kidney, unspecified
0.263 0.737 0.000
I09.8 Other specified rheumatic heart diseases
0.262 0.737 0.000
I09.2 Chronic rheumatic pericarditis
0.262 0.737 0.000
I09.1 Rheumatic diseases of endocardium, valve unspecified
0.262 0.737 0.000
I09.0 Rheumatic myocarditis
0.262 0.737 0.000
J45 Asthma
0.262 0.738 0.000
F19.2 Dependence syndrome
0.261 0.739 0.000
F60 Specific personality disorders
0.261 0.739 0.000
O61 Failed induction of labour
0.260 0.740 0.000
O70.3 Fourth degree perineal laceration during delivery
0.260 0.740 0.000
F99 Mental disorder, not otherwise specified
0.259 0.741 0.000
I06.9 Rheumatic aortic valve disease, unspecified
0.258 0.742 0.000
I06.8 Other rheumatic aortic valve diseases
0.258 0.742 0.000
I06.2 Rheumatic aortic stenosis with insufficiency
0.258 0.742 0.000
I06.1 Rheumatic aortic insufficiency
0.258 0.742 0.000
I06.0 Rheumatic aortic stenosis
0.258 0.742 0.000
J86 Pyothorax
0.258 0.742 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.256 0.744 0.000
Q35-Q37 Cleft lip and cleft palate
0.256 0.744 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.256 0.744 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.256 0.744 0.000
Y91 Evidence of alcohol involvement determined by level of intoxication
0.255 0.745 0.000
F25.1 Schizoaffective disorder, depressive type
0.255 0.745 0.000
O62.0 Primary inadequate contractions
0.255 0.745 0.000
F25.0 Schizoaffective disorder, manic type
0.254 0.746 0.000
F05 Delirium, not induced by alcohol and other psychoactive substances
0.254 0.746 0.000
O73 Retained placenta and membranes, without haemorrhage
0.253 0.747 0.000
F12 Mental and behavioural disorders due to use of cannabinoids
0.252 0.747 0.000
O70.1 Second degree perineal laceration during delivery
0.253 0.747 0.000
X50-X57 Overexertion, travel and privation
0.251 0.749 0.000
X20-X29 Contact with venomous animals and plants
0.251 0.749 0.000
Q50-Q56 Congenital malformations of genital organs
0.251 0.749 0.000
O69.0 Labour and delivery complicated by prolapse of cord
0.251 0.749 0.000
O92 Other disorders of breast and lactation associated with childbirth
0.251 0.749 0.000
O91 Infections of breast associated with childbirth
0.251 0.749 0.000
O89 Complications of anaesthesia during the puerperium
0.251 0.749 0.000
O88 Obstetric embolism
0.251 0.749 0.000
O85 Puerperal sepsis
0.251 0.749 0.000
Y35-Y36 Legal intervention and operations of war
0.251 0.749 0.000
Y10-Y34 Event of undetermined intent
0.251 0.749 0.000
X85-X99 Assault
0.251 0.749 0.000
X30-X39 Exposure to forces of nature
0.251 0.749 0.000
X10-X19 Contact with heat and hot substances
0.251 0.749 0.000
X00-X09 Exposure to smoke, fire and flames
0.251 0.749 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.251 0.749 0.000
W65-W74 Accidental drowning and submersion
0.251 0.749 0.000
V98-V99 Other and unspecified transport accidents
0.251 0.749 0.000
V95-V97 Air and space transport accidents
0.251 0.749 0.000
V90-V94 Water transport accidents
0.251 0.749 0.000
V70-V79 Bus occupant injured in transport accident
0.251 0.749 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.251 0.749 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.251 0.749 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.251 0.749 0.000
J12.9 Viral pneumonia, unspecified
0.250 0.749 0.000
J12.8 Other viral pneumonia
0.250 0.749 0.000
J12.3 Human metapneumovirus pneumonia
0.250 0.749 0.000
J12.2 Parainfluenza virus pneumonia
0.250 0.749 0.000
J12.1 Respiratory syncytial virus pneumonia
0.250 0.749 0.000
J12.0 Adenoviral pneumonia
0.250 0.749 0.000
J16.8 Pneumonia due to other specified infectious organisms
0.250 0.749 0.000
J16.0 Chlamydial pneumonia
0.250 0.749 0.000
O75.0 Maternal distress during labour and delivery
0.250 0.750 0.000
F23 Acute and transient psychotic disorders
0.250 0.750 0.000
I67.9 Cerebrovascular disease, unspecified
0.250 0.750 0.000
O66.5 Failed application of vacuum extractor and forceps, unspecified
0.249 0.751 0.000
O70.9 Perineal laceration during delivery, unspecified
0.248 0.752 0.000
W18 Other fall on same level
0.247 0.753 0.000
Q83 Congenital malformations of breast
0.246 0.754 0.000
J15.0 Pneumonia due to Klebsiella pneumoniae
0.246 0.754 0.000
O63 Long labour
0.246 0.754 0.000
O12.1 Gestational proteinuria
0.246 0.754 0.000
W21 Striking against or struck by sports equipment
0.245 0.755 0.000
I42.8 Other cardiomyopathies
0.245 0.755 0.000
O16 Unspecified maternal hypertension
0.244 0.755 0.000
O22 Venous complications in pregnancy
0.244 0.756 0.000
O12.2 Gestational oedema with proteinuria
0.244 0.756 0.000
F11.9 Unspecified mental and behavioural disorder
0.244 0.756 0.000
F11.8 Other mental and behavioural disorders
0.244 0.756 0.000
F11.7 Residual and late-onset psychotic disorder
0.244 0.756 0.000
F11.6 Amnesic syndrome
0.244 0.756 0.000
F11.5 Psychotic disorder
0.244 0.756 0.000
F11.4 Withdrawal state with delirium
0.244 0.756 0.000
F11.3 Withdrawal state
0.244 0.756 0.000
F11.1 Harmful use
0.244 0.756 0.000
F11.0 Acute intoxication
0.244 0.756 0.000
O62.4 Hypertonic, incoordinate and prolonged uterine contractions
0.244 0.756 0.000
V80-V89 Other land transport accidents
0.244 0.756 0.000
W20 Struck by thrown, projected or falling object
0.244 0.756 0.000
Q87 Other specified congenital malformation syndromes affecting multiple systems
0.243 0.757 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.243 0.757 0.000
J02.8 Acute pharyngitis due to other specified organisms
0.243 0.757 0.000
J02.0 Streptococcal pharyngitis
0.243 0.757 0.000
O71.9 Obstetric trauma, unspecified
0.242 0.757 0.000
O71.6 Obstetric damage to pelvic joints and ligaments
0.242 0.757 0.000
O71.5 Other obstetric injury to pelvic organs
0.242 0.757 0.000
O71.3 Obstetric laceration of cervix
0.242 0.757 0.000
O71.2 Postpartum inversion of uterus
0.242 0.757 0.000
O71.1 Rupture of uterus during labour
0.242 0.757 0.000
O71.0 Rupture of uterus before onset of labour
0.242 0.757 0.000
J84.1 Other interstitial pulmonary diseases with fibrosis
0.243 0.757 0.000
O75.2 Pyrexia during labour, not elsewhere classified
0.242 0.758 0.000
I20.8 Other forms of angina pectoris
0.241 0.758 0.000
Q82 Other congenital malformations of skin
0.242 0.758 0.000
J17.3 Pneumonia in parasitic diseases
0.241 0.759 0.000
O71.8 Other specified obstetric trauma
0.241 0.759 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.241 0.759 0.000
F79 Unspecified mental retardation
0.241 0.759 0.000
I46 Cardiac arrest
0.240 0.760 0.000
I35.2 Aortic (valve) stenosis with insufficiency
0.240 0.760 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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