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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs4648
log Bayes Factor = 17.381
Chromosome 1   position 201,934,578  (GRCh37) Explore rs4648 on Ensembl!
Variant rs4648 is part of Cluster X0079

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter XX External causes of morbidity and mortality
1.000 0.000 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
1.000 0.000 0.000
Chapter XIV Diseases of the genitourinary system
1.000 0.000 0.000
N60-N64 Disorders of breast
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
0.999 0.001 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.999 0.001 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.997 0.003 0.000
N61 Inflammatory disorders of breast
0.997 0.003 0.000
I10-I15 Hypertensive diseases
0.997 0.003 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
0.992 0.008 0.000
N99-N99 Other disorders of the genitourinary system
0.992 0.008 0.000
S80-S89 Injuries to the knee and lower leg
0.991 0.009 0.000
D80-D89 Certain disorders involving the immune mechanism
0.991 0.009 0.000
N17-N19 Renal failure
0.989 0.011 0.000
N64 Other disorders of breast
0.987 0.013 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.987 0.013 0.000
N99 Postprocedural disorders of genito-urinary system, not elsewhere classified
0.986 0.014 0.000
I10 Essential (primary) hypertension
0.985 0.015 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.981 0.019 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.980 0.020 0.000
L85 Other epidermal thickening
0.980 0.020 0.000
Chapter VI Diseases of the nervous system
0.980 0.020 0.000
I60-I69 Cerebrovascular diseases
0.977 0.023 0.000
L85.9 Epidermal thickening, unspecified
0.974 0.026 0.000
D86 Sarcoidosis
0.971 0.029 0.000
S00-S09 Injuries to the head
0.970 0.030 0.000
L97 Ulcer of lower limb, not elsewhere classified
0.970 0.030 0.000
Chapter I Certain infectious and parasitic diseases
0.969 0.031 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.967 0.033 0.000
I69 Sequelae of cerebrovascular disease
0.966 0.034 0.000
S82 Fracture of lower leg, including ankle
0.965 0.035 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.963 0.037 0.000
L40-L45 Papulosquamous disorders
0.957 0.043 0.000
Y43 Primarily systemic agents
0.955 0.045 0.000
S09 Other and unspecified injuries of head
0.954 0.046 0.000
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction
0.954 0.046 0.000
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts
0.953 0.047 0.000
N99.3 Prolapse of vaginal vault after hysterectomy
0.952 0.048 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.950 0.050 0.000
S30 Superficial injury of abdomen, lower back and pelvis
0.949 0.051 0.000
S40-S49 Injuries to the shoulder and upper arm
0.949 0.051 0.000
Chapter V Mental and behavioural disorders
0.946 0.054 0.000
Y42.5 Other oestrogens and progestogens
0.945 0.055 0.000
S82.6 Fracture of lateral malleolus
0.944 0.056 0.000
Chapter XXII Codes for special purposes
0.942 0.058 0.000
S09.9 Unspecified injury of head
0.942 0.058 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.938 0.062 0.000
N18 Chronic renal failure
0.935 0.065 0.000
D86.9 Sarcoidosis, unspecified
0.934 0.066 0.000
L40 Psoriasis
0.930 0.070 0.000
S82.60 Fracture of lateral malleolus (closed)
0.929 0.071 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.929 0.071 0.000
N19 Unspecified renal failure
0.928 0.072 0.000
L84 Corns and callosities
0.928 0.072 0.000
G20-G26 Extrapyramidal and movement disorders
0.927 0.073 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.924 0.076 0.000
T86 Failure and rejection of transplanted organs and tissues
0.924 0.076 0.000
S30.8 Other superficial injuries of abdomen, lower back and pelvis
0.919 0.081 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.918 0.082 0.000
N64.8 Other specified disorders of breast
0.914 0.086 0.000
G81 Hemiplegia
0.913 0.087 0.000
L40.9 Psoriasis, unspecified
0.912 0.088 0.000
N64.9 Disorder of breast, unspecified
0.909 0.091 0.000
I12 Hypertensive renal disease
0.909 0.091 0.000
I73 Other peripheral vascular diseases
0.905 0.095 0.000
Y43.3 Other antineoplastic drugs
0.904 0.096 0.000
S81 Open wound of lower leg
0.902 0.098 0.000
S31 Open wound of abdomen, lower back and pelvis
0.896 0.104 0.000
D86.0 Sarcoidosis of lung
0.895 0.105 0.000
B95-B98 Bacterial, viral and other infectious agents
0.895 0.105 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.892 0.108 0.000
N18.5 Chronic kidney disease, stage 5
0.890 0.110 0.000
B96 Other bacterial agents as the cause of diseases classified to other chapters
0.884 0.116 0.000
D69 Purpura and other haemorrhagic conditions
0.884 0.116 0.000
G81.9 Hemiplegia, unspecified
0.883 0.117 0.000
S40 Superficial injury of shoulder and upper arm
0.882 0.118 0.000
S89 Other and unspecified injuries of lower leg
0.879 0.121 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.875 0.125 0.000
I73.9 Peripheral vascular disease, unspecified
0.875 0.125 0.000
I12.0 Hypertensive renal disease with renal failure
0.867 0.133 0.000
D68 Other coagulation defects
0.864 0.136 0.000
N99.1 Postprocedural urethral stricture
0.862 0.138 0.000
N18.9 Chronic renal failure, unspecified
0.862 0.138 0.000
Q60-Q64 Congenital malformations of the urinary system
0.861 0.139 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.861 0.139 0.000
S82.5 Fracture of medial malleolus
0.861 0.139 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.859 0.141 0.000
D50-D53 Nutritional anaemias
0.858 0.142 0.000
B96.2 Escherichia coli [E. coli] as the cause of diseases classified to other chapters
0.857 0.143 0.000
G24 Dystonia
0.857 0.143 0.000
F03 Unspecified dementia
0.856 0.144 0.000
Y43.4 Immunosuppressive agents
0.855 0.145 0.000
T86.1 Kidney transplant failure and rejection
0.854 0.146 0.000
F02 Dementia in other diseases classified elsewhere
0.853 0.147 0.000
Y52 Agents primarily affecting the cardiovascular system
0.851 0.149 0.000
U80 Agent resistant to penicillin and related antibiotics
0.851 0.149 0.000
T66-T78 Other and unspecified effects of external causes
0.850 0.150 0.000
A30-A49 Other bacterial diseases
0.849 0.151 0.000
G25 Other extrapyramidal and movement disorders
0.848 0.152 0.000
N99.4 Postprocedural pelvic peritoneal adhesions
0.846 0.154 0.000
I73.0 Raynaud's syndrome
0.840 0.160 0.000
S20-S29 Injuries to the thorax
0.839 0.161 0.000
N60 Benign mammary dysplasia
0.839 0.161 0.000
N99.0 Postprocedural renal failure
0.838 0.162 0.000
Y42.8 Other and unspecified hormones and their synthetic substitutes
0.836 0.164 0.000
Y95 Nosocomial condition
0.834 0.166 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.834 0.166 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.832 0.168 0.000
Y57 Other and unspecified drugs and medicaments
0.831 0.169 0.000
L20-L30 Dermatitis and eczema
0.830 0.170 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.827 0.173 0.000
V01-V09 Pedestrian injured in transport accident
0.826 0.174 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.825 0.175 0.000
N18.0 End-stage renal disease
0.825 0.175 0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.825 0.175 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.821 0.179 0.000
I67 Other cerebrovascular diseases
0.820 0.180 0.000
I63 Cerebral infarction
0.819 0.181 0.000
B96.8 Other specified bacterial agents as the cause of diseases classified to other chapters
0.818 0.182 0.000
S01 Open wound of head
0.817 0.183 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.817 0.183 0.000
Q61 Cystic kidney disease
0.817 0.183 0.000
Y00-Y09 Assault
0.814 0.186 0.000
G90-G99 Other disorders of the nervous system
0.814 0.186 0.000
G25.3 Myoclonus
0.812 0.188 0.000
L93 Lupus erythematosus
0.812 0.188 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.812 0.188 0.000
N17 Acute renal failure
0.812 0.188 0.000
I11 Hypertensive heart disease
0.811 0.189 0.000
N64.4 Mastodynia
0.811 0.189 0.000
D69.3 Idiopathic thrombocytopenic purpura
0.811 0.189 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.810 0.190 0.000
G24.9 Dystonia, unspecified
0.807 0.193 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.806 0.194 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.806 0.194 0.000
G63.2 Diabetic polyneuropathy
0.804 0.196 0.000
D55-D59 Haemolytic anaemias
0.804 0.196 0.000
S10-S19 Injuries to the neck
0.802 0.198 0.000
D83 Common variable immunodeficiency
0.802 0.198 0.000
Y42.3 Insulin and oral hypoglycaemic [antidiabetic] drugs
0.800 0.200 0.000
I15 Secondary hypertension
0.799 0.200 0.000
Y44 Agents primarily affecting blood constituents
0.799 0.201 0.000
S06 Intracranial injury
0.799 0.201 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.799 0.201 0.000
T87 Complications peculiar to reattachment and amputation
0.799 0.201 0.000
S82.0 Fracture of patella
0.798 0.202 0.000
S40.9 Superficial injury of shoulder and upper arm, unspecified
0.797 0.203 0.000
I69.8 Sequelae of other and unspecified cerebrovascular diseases
0.795 0.205 0.000
S30.9 Superficial injury of abdomen, lower back and pelvis, part unspecified
0.794 0.206 0.000
I69.1 Sequelae of intracerebral haemorrhage
0.794 0.206 0.000
F99-F99 Unspecified mental disorder
0.793 0.207 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.793 0.207 0.000
N64.1 Fat necrosis of breast
0.792 0.208 0.000
W50-W64 Exposure to animate mechanical forces
0.792 0.208 0.000
S81.9 Open wound of lower leg, part unspecified
0.789 0.211 0.000
F60-F69 Disorders of adult personality and behaviour
0.788 0.212 0.000
T86.0 Bone-marrow transplant rejection
0.787 0.213 0.000
S82.50 Fracture of medial malleolus (closed)
0.787 0.213 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.786 0.214 0.000
G83 Other paralytic syndromes
0.783 0.217 0.000
F01 Vascular dementia
0.783 0.217 0.000
S89.9 Unspecified injury of lower leg
0.782 0.218 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.782 0.218 0.000
I05-I09 Chronic rheumatic heart diseases
0.782 0.218 0.000
D80 Immunodeficiency with predominantly antibody defects
0.782 0.218 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.781 0.219 0.000
S90-S99 Injuries to the ankle and foot
0.780 0.219 0.000
Y52.5 Other antihypertensive drugs, not elsewhere classified
0.779 0.221 0.000
S39 Other and unspecified injuries of abdomen, lower back and pelvis
0.777 0.223 0.000
X10-X19 Contact with heat and hot substances
0.777 0.223 0.000
T82.1 Mechanical complication of cardiac electronic device
0.776 0.224 0.000
B96.5 Pseudomonas (aeruginosa)(mallei)(pseudomallei) as the cause of diseases classified to other chapters
0.775 0.225 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.773 0.226 0.000
S70-S79 Injuries to the hip and thigh
0.773 0.227 0.000
S49 Other and unspecified injuries of shoulder and upper arm
0.773 0.227 0.000
X60-X84 Intentional self-harm
0.773 0.227 0.000
B00 Herpesviral [herpes simplex] infections
0.772 0.228 0.000
I63.9 Cerebral infarction, unspecified
0.772 0.228 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.772 0.228 0.000
D50 Iron deficiency anaemia
0.770 0.230 0.000
V20-V29 Motorcycle rider injured in transport accident
0.768 0.232 0.000
V80-V89 Other land transport accidents
0.768 0.232 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.767 0.233 0.000
Y91 Evidence of alcohol involvement determined by level of intoxication
0.766 0.234 0.000
N99.8 Other postprocedural disorders of genito-urinary system
0.766 0.234 0.000
S01.3 Open wound of ear
0.766 0.234 0.000
Y49.5 Other antipsychotics and neuroleptics
0.765 0.235 0.000
S31.4 Open wound of vagina and vulva
0.765 0.235 0.000
Y51.7 Beta-Adrenoreceptor antagonists, not elsewhere classified
0.765 0.235 0.000
S31.1 Open wound of abdominal wall
0.764 0.236 0.000
B35-B49 Mycoses
0.761 0.239 0.000
I80 Phlebitis and thrombophlebitis
0.761 0.239 0.000
L94 Other localised connective tissue disorders
0.759 0.241 0.000
S82.4 Fracture of fibula alone
0.759 0.241 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.759 0.241 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.759 0.241 0.000
S20 Superficial injury of thorax
0.758 0.242 0.000
L91 Hypertrophic disorders of skin
0.758 0.242 0.000
D50.8 Other iron deficiency anaemias
0.758 0.242 0.000
F06 Other mental disorders due to brain damage and dysfunction and to physical disease
0.757 0.243 0.000
L10-L14 Bullous disorders
0.756 0.243 0.000
U80.0 Penicillin resistant agent
0.756 0.244 0.000
S40.0 Contusion of shoulder and upper arm
0.756 0.244 0.000
Y59 Other and unspecified vaccines and biological substances
0.756 0.244 0.000
Chapter VIII Diseases of the ear and mastoid process
0.754 0.246 0.000
D68.8 Other specified coagulation defects
0.754 0.246 0.000
I80.2 Phlebitis and thrombophlebitis of other deep vessels of lower extremities
0.753 0.247 0.000
I67.1 Cerebral aneurysm, nonruptured
0.753 0.247 0.000
U80.1 Methicillin resistant agent
0.750 0.250 0.000
T00-T07 Injuries involving multiple body regions
0.750 0.250 0.000
G82 Paraplegia and tetraplegia
0.749 0.250 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.748 0.252 0.000
Q00-Q07 Congenital malformations of the nervous system
0.747 0.253 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.747 0.253 0.000
N99.5 Malfunction of external stoma of urinary tract
0.747 0.253 0.000
S41 Open wound of shoulder and upper arm
0.747 0.253 0.000
Q61.2 Polycystic kidney, adult type
0.746 0.254 0.000
L28 Lichen simplex chronicus and prurigo
0.746 0.254 0.000
L80 Vitiligo
0.745 0.255 0.000
F02.3 Dementia in Parkinson's disease
0.744 0.256 0.000
T82.6 Infection and inflammatory reaction due to cardiac valve prosthesis
0.744 0.256 0.000
S81.8 Open wound of other parts of lower leg
0.742 0.258 0.000
I63.2 Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
0.739 0.261 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.738 0.262 0.000
S01.5 Open wound of lip and oral cavity
0.737 0.263 0.000
L92 Granulomatous disorders of skin and subcutaneous tissue
0.736 0.264 0.000
I62 Other nontraumatic intracranial haemorrhage
0.733 0.267 0.000
A40 Streptococcal septicaemia
0.732 0.268 0.000
L50-L54 Urticaria and erythema
0.732 0.268 0.000
D84 Other immunodeficiencies
0.731 0.269 0.000
S46 Injury of muscle and tendon at shoulder and upper arm level
0.728 0.272 0.000
V98-V99 Other and unspecified transport accidents
0.727 0.273 0.000
B37 Candidiasis
0.725 0.275 0.000
G95 Other diseases of spinal cord
0.724 0.276 0.000
S09.8 Other specified injuries of head
0.724 0.276 0.000
B96.1 Klebsiella pneumoniae [K. pneumoniae] as the cause of diseases classified to other chapters
0.724 0.276 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.724 0.276 0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs
0.723 0.277 0.000
I60 Subarachnoid haemorrhage
0.722 0.278 0.000
T80.1 Vascular complications following infusion, transfusion and therapeutic injection
0.720 0.280 0.000
N60.4 Mammary duct ectasia
0.720 0.280 0.000
T82.5 Mechanical complication of other cardiac and vascular devices and implants
0.720 0.280 0.000
N64.5 Other signs and symptoms in breast
0.719 0.281 0.000
G90 Disorders of autonomic nervous system
0.718 0.282 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
Y35-Y36 Legal intervention and operations of war
0.717 0.283 0.000
Y10-Y34 Event of undetermined intent
0.717 0.283 0.000
X85-X99 Assault
0.717 0.283 0.000
X30-X39 Exposure to forces of nature
0.717 0.283 0.000
X00-X09 Exposure to smoke, fire and flames
0.717 0.283 0.000
W75-W84 Other accidental threats to breathing
0.717 0.283 0.000
W65-W74 Accidental drowning and submersion
0.717 0.283 0.000
V95-V97 Air and space transport accidents
0.717 0.283 0.000
V90-V94 Water transport accidents
0.717 0.283 0.000
V70-V79 Bus occupant injured in transport accident
0.717 0.283 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.717 0.283 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.717 0.283 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.717 0.283 0.000
Y58 Bacterial vaccines
0.717 0.283 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.717 0.283 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.717 0.283 0.000
Y48 Anaesthetics and therapeutic gases
0.717 0.283 0.000
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.716 0.284 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.716 0.284 0.000
D69.0 Allergic purpura
0.716 0.284 0.000
I13 Hypertensive heart and renal disease
0.714 0.285 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.714 0.286 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.713 0.287 0.000
L83 Acanthosis nigricans
0.712 0.288 0.000
A65-A69 Other spirochaetal diseases
0.712 0.288 0.000
D66 Hereditary factor VIII deficiency
0.712 0.288 0.000
A15-A19 Tuberculosis
0.712 0.288 0.000
L99 Other disorders of skin and subcutaneous tissue in diseases classified elsewhere
0.711 0.289 0.000
L87 Transepidermal elimination disorders
0.711 0.289 0.000
L88 Pyoderma gangrenosum
0.711 0.289 0.000
L86 Keratoderma in diseases classified elsewhere
0.711 0.289 0.000
D68.3 Haemorrhagic disorder due to circulating anticoagulants
0.711 0.289 0.000
I85 Oesophageal varices
0.711 0.289 0.000
S88 Traumatic amputation of lower leg
0.711 0.289 0.000
S87 Crushing injury of lower leg
0.711 0.289 0.000
S85 Injury of blood vessels at lower leg level
0.711 0.289 0.000
S84 Injury of nerves at lower leg level
0.711 0.289 0.000
D82 Immunodeficiency associated with other major defects
0.710 0.289 0.000
D81 Combined immunodeficiencies
0.710 0.289 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.710 0.290 0.000
Y00 Assault by blunt object
0.710 0.290 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.709 0.291 0.000
B00.1 Herpesviral vesicular dermatitis
0.709 0.291 0.000
B65-B83 Helminthiases
0.709 0.291 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.709 0.291 0.000
N64.3 Galactorrhoea not associated with childbirth
0.708 0.292 0.000
N64.2 Atrophy of breast
0.708 0.292 0.000
N64.0 Fissure and fistula of nipple
0.708 0.292 0.000
N99.9 Postprocedural disorder of genito-urinary system, unspecified
0.707 0.293 0.000
Y42.7 Androgens and anabolic congeners
0.707 0.293 0.000
Y42.6 Antigonadotrophins, antioestrogens, antiandrogens, not elsewhere classified
0.706 0.294 0.000
T82.4 Mechanical complication of vascular dialysis catheter
0.705 0.295 0.000
X50-X57 Overexertion, travel and privation
0.705 0.295 0.000
S42 Fracture of shoulder and upper arm
0.704 0.296 0.000
Y42.9 Other and unspecified hormone antagonists
0.703 0.297 0.000
Y42.4 Oral contraceptives
0.703 0.297 0.000
Y42.2 Antithyroid drugs
0.703 0.297 0.000
Y42.1 Thyroid hormones and substitutes
0.703 0.297 0.000
S38 Crushing injury and traumatic amputation of part of abdomen, lower back and pelvis
0.703 0.297 0.000
S36 Injury of intra-abdominal organs
0.703 0.297 0.000
S35 Injury of blood vessels at abdomen, lower back and pelvis level
0.703 0.297 0.000
S34 Injury of nerves and lumbar spinal cord at abdomen, lower back and pelvis level
0.703 0.297 0.000
S33 Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis
0.703 0.297 0.000
L85.3 Xerosis cutis
0.703 0.297 0.000
L85.2 Keratosis punctata (palmaris et plantaris)
0.703 0.297 0.000
L85.1 Acquired keratosis [keratoderma] palmaris et plantaris
0.703 0.297 0.000
L85.0 Acquired ichthyosis
0.703 0.297 0.000
F02.0 Dementia in Pick's disease
0.702 0.298 0.000
S01.9 Open wound of head, part unspecified
0.701 0.299 0.000
V04 Pedestrian injured in collision with heavy transport vehicle or bus
0.701 0.299 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.701 0.299 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.701 0.299 0.000
N00-N08 Glomerular diseases
0.700 0.300 0.000
T82.9 Unspecified complication of cardiac and vascular prosthetic device, implant and graft
0.700 0.300 0.000
D68.6 Other Thrombophilia
0.699 0.301 0.000
I67.8 Other specified cerebrovascular diseases
0.698 0.302 0.000
S81.7 Multiple open wounds of lower leg
0.698 0.302 0.000
S30.2 Contusion of external genital organs
0.698 0.302 0.000
S37 Injury of urinary and pelvic organs
0.697 0.303 0.000
B91 Sequelae of poliomyelitis
0.697 0.303 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.696 0.304 0.000
D86.3 Sarcoidosis of skin
0.696 0.304 0.000
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.696 0.304 0.000
S08 Traumatic amputation of part of head
0.695 0.305 0.000
S07 Crushing injury of head
0.695 0.305 0.000
S04 Injury of cranial nerves
0.695 0.305 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.695 0.305 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.695 0.305 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.695 0.305 0.000
A75-A79 Rickettsioses
0.695 0.305 0.000
A70-A74 Other diseases caused by chlamydiae
0.695 0.305 0.000
A20-A28 Certain zoonotic bacterial diseases
0.695 0.305 0.000
D86.8 Sarcoidosis of other and combined sites
0.695 0.305 0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.695 0.305 0.000
F05 Delirium, not induced by alcohol and other psychoactive substances
0.693 0.307 0.000
I69.2 Sequelae of other nontraumatic intracranial haemorrhage
0.692 0.308 0.000
Y56.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified
0.692 0.308 0.000
S82.9 Fracture of lower leg, part unspecified
0.692 0.308 0.000
S82.7 Multiple fractures of lower leg
0.692 0.308 0.000
L40.8 Other psoriasis
0.692 0.308 0.000
G95.2 Cord compression, unspecified
0.692 0.308 0.000
B99-B99 Other infectious diseases
0.691 0.309 0.000
L40.0 Psoriasis vulgaris
0.691 0.309 0.000
L95 Vasculitis limited to skin, not elsewhere classified
0.690 0.310 0.000
D67 Hereditary factor IX deficiency
0.690 0.310 0.000
T68 Hypothermia
0.690 0.310 0.000
X20-X29 Contact with venomous animals and plants
0.689 0.311 0.000
L44 Other papulosquamous disorders
0.686 0.314 0.000
L41 Parapsoriasis
0.686 0.314 0.000
L45 Papulosquamous disorders in diseases classified elsewhere
0.686 0.314 0.000
L42 Pityriasis rosea
0.686 0.314 0.000
Q61.3 Polycystic kidney, unspecified
0.686 0.314 0.000
N60.1 Diffuse cystic mastopathy
0.686 0.314 0.000
Y47.1 Benzodiazepines
0.685 0.314 0.000
T87.6 Other and unspecified complications of amputation stump
0.685 0.315 0.000
I11.9 Hypertensive heart disease without (congestive) heart failure
0.685 0.315 0.000
D68.0 Von Willebrand's disease
0.685 0.315 0.000
Q18 Other congenital malformations of face and neck
0.685 0.315 0.000
Y43.9 Primarily systemic agent, unspecified
0.684 0.315 0.000
Y43.8 Other primarily systemic agents, not elsewhere classified
0.684 0.315 0.000
Y43.6 Enzymes, not elsewhere classified
0.684 0.315 0.000
Y43.5 Acidifying and alkalising agents
0.684 0.315 0.000
Y43.2 Antineoplastic natural products
0.684 0.315 0.000
S09.7 Multiple injuries of head
0.684 0.316 0.000
S09.2 Traumatic rupture of ear drum
0.684 0.316 0.000
S09.1 Injury of muscle and tendon of head
0.684 0.316 0.000
S09.0 Injury of blood vessels of head, not elsewhere classified
0.684 0.316 0.000
F70-F79 Mental retardation
0.684 0.316 0.000
G81.1 Spastic hemiplegia
0.684 0.316 0.000
U81 Agent resistant to vancomycin and related antibiotics
0.684 0.316 0.000
F99 Mental disorder, not otherwise specified
0.684 0.316 0.000
A49 Bacterial infection of unspecified site
0.684 0.316 0.000
N17.8 Other acute renal failure
0.684 0.316 0.000
L93.0 Discoid lupus erythematosus
0.683 0.316 0.000
G25.0 Essential tremor
0.682 0.318 0.000
S30.7 Multiple superficial injuries of abdomen, lower back and pelvis
0.681 0.319 0.000
S48 Traumatic amputation of shoulder and upper arm
0.680 0.320 0.000
S45 Injury of blood vessels at shoulder and upper arm level
0.680 0.320 0.000
S44 Injury of nerves at shoulder and upper arm level
0.680 0.320 0.000
S47 Crushing injury of shoulder and upper arm
0.680 0.320 0.000
T22 Burn and corrosion of shoulder and upper limb, except wrist and hand
0.679 0.321 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.678 0.322 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.678 0.322 0.000
F01.9 Vascular dementia, unspecified
0.678 0.322 0.000
X59 Exposure to unspecified factor
0.678 0.322 0.000
S82.61 Fracture of lateral malleolus (open)
0.677 0.323 0.000
S50-S59 Injuries to the elbow and forearm
0.676 0.324 0.000
B15-B19 Viral hepatitis
0.674 0.326 0.000
Y51.6 @-Adrenoreceptor antagonists, not elsewhere classified
0.674 0.326 0.000
I80.0 Phlebitis and thrombophlebitis of superficial vessels of lower extremities
0.673 0.327 0.000
Q35-Q37 Cleft lip and cleft palate
0.673 0.327 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.673 0.327 0.000
U80.8 Agent resistant to other penicillin-related antibiotic
0.672 0.328 0.000
S89.8 Other specified injuries of lower leg
0.672 0.328 0.000
L43 Lichen planus
0.672 0.328 0.000
I86 Varicose veins of other sites
0.672 0.328 0.000
Q50-Q56 Congenital malformations of genital organs
0.671 0.328 0.000
S31.0 Open wound of lower back and pelvis
0.671 0.329 0.000
Y49.0 Tricyclic and tetracyclic antidepressants
0.671 0.329 0.000
D69.4 Other primary thrombocytopenia
0.671 0.329 0.000
N18.1 Chronic kidney disease, stage 1
0.671 0.329 0.000
S86 Injury of muscle and tendon at lower leg level
0.670 0.330 0.000
S82.3 Fracture of lower end of tibia
0.670 0.330 0.000
L29 Pruritus
0.669 0.331 0.000
S11 Open wound of neck
0.668 0.331 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.668 0.332 0.000
N25-N29 Other disorders of kidney and ureter
0.668 0.332 0.000
F80-F89 Disorders of psychological development
0.668 0.332 0.000
Y41.8 Other specified systemic anti-infectives and antiparasitics
0.667 0.333 0.000
L40.4 Guttate psoriasis
0.667 0.333 0.000
L40.3 Pustulosis palmaris et plantaris
0.667 0.333 0.000
L40.2 Acrodermatitis continua
0.667 0.333 0.000
L40.1 Generalised pustular psoriasis
0.667 0.333 0.000
D83.9 Common variable immunodeficiency, unspecified
0.667 0.333 0.000
F07 Personality and behavioural disorders due to brain disease, damage and dysfunction
0.666 0.334 0.000
F09 Unspecified organic or symptomatic mental disorder
0.666 0.334 0.000
F04 Organic amnesic syndrome, not induced by alcohol and other psychoactive substances
0.666 0.334 0.000
D51 Vitamin B12 deficiency anaemia
0.665 0.334 0.000
T88.7 Unspecified adverse effect of drug or medicament
0.665 0.335 0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee
0.665 0.335 0.000
G23 Other degenerative diseases of basal ganglia
0.664 0.335 0.000
G21 Secondary Parkinsonism
0.664 0.335 0.000
G26 Extrapyramidal and movement disorders in diseases classified elsewhere
0.664 0.335 0.000
G22 Parkinsonism in diseases classified elsewhere
0.664 0.335 0.000
G24.8 Other dystonia
0.664 0.336 0.000
S06.2 Diffuse brain injury
0.663 0.337 0.000
Y90 Evidence of alcohol involvement determined by blood alcohol level
0.663 0.337 0.000
Y98 Lifestyle-related condition
0.663 0.337 0.000
Y97 Environmental-pollution-related condition
0.663 0.337 0.000
Y96 Work-related condition
0.663 0.337 0.000
T88.4 Failed or difficult intubation
0.663 0.337 0.000
T86.9 Failure and rejection of unspecified transplanted organ and tissue
0.662 0.338 0.000
T86.4 Liver transplant failure and rejection
0.662 0.338 0.000
T86.3 Heart-lung transplant failure and rejection
0.662 0.338 0.000
T86.2 Heart transplant failure and rejection
0.662 0.338 0.000
S82.00 Fracture of patella (closed)
0.662 0.338 0.000
A00-A09 Intestinal infectious diseases
0.662 0.338 0.000
Y57.8 Other drugs and medicaments
0.661 0.339 0.000
T75 Effects of other external causes
0.660 0.340 0.000
N60.8 Other benign mammary dysplasias
0.660 0.340 0.000
S06.3 Focal brain injury
0.659 0.341 0.000
I15.1 Hypertension secondary to other renal disorders
0.659 0.341 0.000
Y40 Systemic antibiotics
0.658 0.341 0.000
I72 Other aneurysm
0.658 0.342 0.000
F02.8 Dementia in other specified diseases classified elsewhere
0.657 0.343 0.000
F60 Specific personality disorders
0.657 0.343 0.000
S99 Other and unspecified injuries of ankle and foot
0.657 0.343 0.000
B37.8 Candidiasis of other sites
0.657 0.343 0.000
G11 Hereditary ataxia
0.656 0.344 0.000
Y44.2 Anticoagulants
0.656 0.344 0.000
Y42.0 Glucocorticoids and synthetic analogs
0.655 0.345 0.000
I88 Nonspecific lymphadenitis
0.655 0.345 0.000
S20.8 Superficial injuries of other and unspecified parts of thorax
0.655 0.345 0.000
G81.0 Flaccid hemiplegia
0.655 0.345 0.000
V40-V49 Car occupant injured in transport accident
0.654 0.346 0.000
T82.2 Mechanical complication of coronary artery bypass and valve grafts
0.654 0.346 0.000
Y57.5 X-ray contrast media
0.653 0.346 0.000
Y91.9 Alcohol involvement, not otherwise specified
0.653 0.347 0.000
B50-B64 Protozoal diseases
0.653 0.347 0.000
S29 Other and unspecified injuries of thorax
0.652 0.347 0.000
A80-A89 Viral infections of the central nervous system
0.652 0.348 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.652 0.348 0.000
S60-S69 Injuries to the wrist and hand
0.651 0.349 0.000
G96 Other disorders of central nervous system
0.649 0.351 0.000
W00-W19 Falls
0.649 0.351 0.000
I73.1 Thromboangiitis obliterans [Buerger]
0.648 0.351 0.000
S49.9 Unspecified injury of shoulder and upper arm
0.647 0.353 0.000
I08 Multiple valve diseases
0.647 0.353 0.000
D59 Acquired haemolytic anaemia
0.646 0.354 0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.646 0.354 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.645 0.355 0.000
G83.1 Monoplegia of lower limb
0.645 0.355 0.000
S82.2 Fracture of shaft of tibia
0.644 0.356 0.000
G91 Hydrocephalus
0.644 0.356 0.000
T39.0 Salicylates
0.644 0.356 0.000
G82.2 Paraplegia, unspecified
0.644 0.356 0.000
B00.5 Herpesviral ocular disease
0.643 0.357 0.000
A49.0 Staphylococcal infection, unspecified
0.643 0.357 0.000
Y46.4 Iminostilbenes
0.643 0.357 0.000
D89.0 Polyclonal hypergammaglobulinaemia
0.643 0.357 0.000
S31.8 Open wound of other and unspecified parts of abdomen
0.642 0.357 0.000
S31.7 Multiple open wounds of abdomen, lower back and pelvis
0.642 0.357 0.000
S31.5 Open wound of other and unspecified external genital organs
0.642 0.357 0.000
S31.3 Open wound of scrotum and testes
0.642 0.357 0.000
S31.2 Open wound of penis
0.642 0.357 0.000
T88.6 Anaphylactic shock due to adverse effect of correct drug or medicament properly administered
0.640 0.360 0.000
I85.9 Oesophageal varices without bleeding
0.640 0.360 0.000
T85.3 Mechanical complication of other ocular prosthetic devices, imnplants and grafts
0.640 0.360 0.000
S30.1 Contusion of abdominal wall
0.640 0.360 0.000
N17.0 Acute renal failure with tubular necrosis
0.640 0.360 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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