TreeWAS – Variant ID: rs4711253

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E03.9 Hypothyroidism, unspecified	0.000	0.000	1.000
K90.0 Coeliac disease	0.000	0.000	1.000
M06.9 Rheumatoid arthritis, unspecified	1.000	0.000	0.000
M05-M14 Inflammatory polyarthropathies	1.000	0.000	0.000
M45.X9 Ankylosing spondylitis (Site unspecified)	1.000	0.000	0.000
M06 Other rheumatoid arthritis	1.000	0.000	0.000
M05.9 Seropositive rheumatoid arthritis, unspecified	1.000	0.000	0.000
M05 Seropositive rheumatoid arthritis	1.000	0.000	0.000
M45 Ankylosing spondylitis	1.000	0.000	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	1.000	0.000	0.000
M45-M49 Spondylopathies	0.999	0.001	0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.999	0.001	0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)	0.998	0.002	0.000
M70-M79 Other soft tissue disorders	0.995	0.005	0.000
M75 Shoulder lesions	0.995	0.005	0.000
E10.9 Without complications	0.991	0.009	0.000
E10 Insulin-dependent diabetes mellitus	0.990	0.010	0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.985	0.015	0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)	0.982	0.018	0.000
M75.4 Impingement syndrome of shoulder	0.978	0.022	0.000
M45.X0 Ankylosing spondylitis (Multiple sites in spine)	0.955	0.045	0.000
E10.1 With ketoacidosis	0.950	0.050	0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)	0.944	0.056	0.000
M75.3 Calcific tendinitis of shoulder	0.939	0.061	0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.927	0.073	0.000
M06.3 Rheumatoid nodule	0.926	0.074	0.000
M75.2 Bicipital tendinitis	0.909	0.091	0.000
Z88.0 Personal history of allergy to penicillin	0.893	0.107	0.000
M00-M03 Infectious arthropathies	0.892	0.108	0.000
E03 Other hypothyroidism	0.002	0.111	0.887
M75.1 Rotator cuff syndrome	0.878	0.122	0.000
E10.5 With peripheral circulatory complications	0.875	0.125	0.000
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)	0.875	0.125	0.000
E10.4 With neurological complications	0.855	0.145	0.000
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.850	0.150	0.000
E10-E14 Diabetes mellitus	0.848	0.152	0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.846	0.154	0.000
M45.X2 Ankylosing spondylitis (Cervical region)	0.845	0.155	0.000
M12 Other specific arthropathies	0.840	0.160	0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)	0.835	0.165	0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)	0.833	0.167	0.000
M06.34 Rheumatoid nodule (Hand)	0.832	0.168	0.000
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)	0.831	0.169	0.000
M49 Spondylopathies in diseases classified elsewhere	0.826	0.174	0.000
M75.5 Bursitis of shoulder	0.824	0.176	0.000
E10.0 With coma	0.821	0.179	0.000
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)	0.815	0.185	0.000
M06.0 Seronegative rheumatoid arthritis	0.813	0.187	0.000
M00 Pyogenic arthritis	0.811	0.189	0.000
M80-M85 Disorders of bone density and structure	0.799	0.201	0.000
M65-M68 Disorders of synovium and tendon	0.795	0.205	0.000
E10.6 With other specified complications	0.791	0.209	0.000
M40-M43 Deforming dorsopathies	0.790	0.210	0.000
M06.98 Rheumatoid arthritis, unspecified (Other)	0.787	0.213	0.000
E14 Unspecified diabetes mellitus	0.784	0.216	0.000
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)	0.782	0.218	0.000
M14 Arthropathies in other diseases classified elsewhere	0.776	0.224	0.000
E10.7 With multiple complications	0.773	0.227	0.000
E10.8 With unspecified complications	0.772	0.228	0.000
M60-M63 Disorders of muscles	0.770	0.229	0.000
M75.9 Shoulder lesion, unspecified	0.763	0.237	0.000
M00.9 Pyogenic arthritis, unspecified	0.753	0.247	0.000
M06.32 Rheumatoid nodule (Upper arm)	0.751	0.249	0.000
M05.8 Other seropositive rheumatoid arthritis	0.737	0.262	0.000
M41 Scoliosis	0.737	0.263	0.000
E14.9 Without complications	0.734	0.266	0.000
E03.8 Other specified hypothyroidism	0.001	0.274	0.725
M91-M94 Chondropathies	0.722	0.277	0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.001	0.278	0.721
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.722	0.278	0.000
M06.4 Inflammatory polyarthropathy	0.720	0.280	0.000
M06.30 Rheumatoid nodule (Multiple sites)	0.718	0.282	0.000
M09 Juvenile arthritis in diseases classified elsewhere	0.717	0.283	0.000
M08 Juvenile arthritis	0.717	0.283	0.000
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)	0.717	0.283	0.000
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)	0.717	0.283	0.000
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)	0.717	0.283	0.000
M06.8 Other specified rheumatoid arthritis	0.717	0.283	0.000
M06.2 Rheumatoid bursitis	0.717	0.283	0.000
M06.1 Adult-onset Still's disease	0.717	0.283	0.000
M05.3 Rheumatoid arthritis with involvement of other organs and systems	0.717	0.283	0.000
M05.2 Rheumatoid vasculitis	0.717	0.283	0.000
M05.1 Rheumatoid lung disease	0.717	0.283	0.000
M05.0 Felty's syndrome	0.717	0.283	0.000
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)	0.717	0.283	0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)	0.717	0.283	0.000
M45.X6 Ankylosing spondylitis (Lumbar region)	0.717	0.283	0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)	0.717	0.283	0.000
M45.X4 Ankylosing spondylitis (Thoracic region)	0.717	0.283	0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)	0.717	0.283	0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)	0.717	0.283	0.000
M76 Enthesopathies of lower limb, excluding foot	0.716	0.284	0.000
M73 Soft tissue disorders in diseases classified elsewhere	0.714	0.286	0.000
M75.8 Other shoulder lesions	0.713	0.287	0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.712	0.288	0.000
M00.96 Pyogenic arthritis, unspecified (Lower leg)	0.708	0.292	0.000
E10.3 With ophthalmic complications	0.708	0.292	0.000
E00-E07 Disorders of thyroid gland	0.017	0.293	0.690
M71 Other bursopathies	0.704	0.296	0.000
M49.5 Collapsed vertebra in diseases classified elsewhere	0.702	0.298	0.000
M70 Soft tissue disorders related to use, overuse and pressure	0.696	0.304	0.000
M41.9 Scoliosis, unspecified	0.695	0.305	0.000
M06.09 Seronegative rheumatoid arthritis (Site unspecified)	0.693	0.307	0.000
M12.3 Palindromic rheumatism	0.688	0.312	0.000
M46 Other inflammatory spondylopathies	0.686	0.314	0.000
M77 Other enthesopathies	0.684	0.315	0.000
E11 Non-insulin-dependent diabetes mellitus	0.681	0.319	0.000
M65 Synovitis and tenosynovitis	0.677	0.323	0.000
M82 Osteoporosis in diseases classified elsewhere	0.675	0.325	0.000
M80 Osteoporosis with pathological fracture	0.674	0.326	0.000
E05 Thyrotoxicosis [hyperthyroidism]	0.003	0.327	0.670
M66 Spontaneous rupture of synovium and tendon	0.668	0.332	0.000
M06.39 Rheumatoid nodule (Site unspecified)	0.664	0.336	0.000
M06.38 Rheumatoid nodule (Other)	0.664	0.336	0.000
M06.36 Rheumatoid nodule (Lower leg)	0.664	0.336	0.000
M06.35 Rheumatoid nodule (Pelvic region and thigh)	0.664	0.336	0.000
M06.33 Rheumatoid nodule (Forearm)	0.664	0.336	0.000
M06.31 Rheumatoid nodule (Shoulder region)	0.664	0.336	0.000
E05.9 Thyrotoxicosis, unspecified	0.000	0.339	0.660
M12.2 Villonodular synovitis (pigmented)	0.660	0.340	0.000
M07 Psoriatic and enteropathic arthropathies	0.654	0.346	0.000
M02 Reactive arthropathies	0.653	0.347	0.000
M06.37 Rheumatoid nodule (Ankle and foot)	0.651	0.349	0.000
M41.96 Scoliosis, unspecified (Lumbar region)	0.644	0.356	0.000
E10.2 With renal complications	0.640	0.360	0.000
M03 Postinfective and reactive arthropathies in diseases classified elsewhere	0.640	0.360	0.000
M01 Direct infections of joint in infectious and parasitic diseases classified elsewhere	0.640	0.360	0.000
E03.5 Myxoedema coma	0.002	0.363	0.636
E03.4 Atrophy of thyroid (acquired)	0.002	0.363	0.636
E03.3 Postinfectious hypothyroidism	0.002	0.363	0.636
E03.1 Congenital hypothyroidism without goitre	0.002	0.363	0.636
E03.0 Congenital hypothyroidism with diffuse goitre	0.002	0.363	0.636
E11.4 With neurological complications	0.637	0.363	0.000
M62 Other disorders of muscle	0.635	0.365	0.000
E13 Other specified diabetes mellitus	0.633	0.367	0.000
M49.54 Collapsed vertebra in diseases classified elsewhere (Thoracic region)	0.620	0.380	0.000
M14.6 Neuropathic arthropathy	0.616	0.384	0.000
M65.9 Synovitis and tenosynovitis, unspecified	0.612	0.388	0.000
E12 Malnutrition-related diabetes mellitus	0.608	0.392	0.000
M11 Other crystal arthropathies	0.606	0.394	0.000
M66.2 Spontaneous rupture of extensor tendons	0.606	0.394	0.000
E07 Other disorders of thyroid	0.007	0.394	0.599
M92 Other juvenile osteochondrosis	0.603	0.397	0.000
M12.8 Other specific arthropathies, not elsewhere classified	0.602	0.398	0.000
M12.5 Traumatic arthropathy	0.602	0.398	0.000
M12.4 Intermittent hydrarthrosis	0.602	0.398	0.000
M12.1 Kaschin-Beck disease	0.602	0.398	0.000
M12.0 Chronic postrheumatic arthropathy [Jaccoud]	0.602	0.398	0.000
E14.6 With other specified complications	0.596	0.404	0.000
M49.8 Spondylopathy in other diseases classified elsewhere	0.592	0.407	0.000
M49.4 Neuropathic spondylopathy	0.592	0.407	0.000
M49.3 Spondylopathy in other infectious and parasitic diseases classified elsewhere	0.592	0.407	0.000
M49.2 Enterobacterial spondylitis	0.592	0.407	0.000
M49.1 Brucella spondylitis	0.592	0.407	0.000
M49.0 Tuberculosis of spine	0.592	0.407	0.000
M82.1 Osteoporosis in endocrine disorders	0.587	0.413	0.000
M06.08 Seronegative rheumatoid arthritis (Other)	0.583	0.417	0.000
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)	0.583	0.417	0.000
M06.06 Seronegative rheumatoid arthritis (Lower leg)	0.583	0.417	0.000
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)	0.583	0.417	0.000
M06.04 Seronegative rheumatoid arthritis (Hand)	0.583	0.417	0.000
M06.03 Seronegative rheumatoid arthritis (Forearm)	0.583	0.417	0.000
M06.02 Seronegative rheumatoid arthritis (Upper arm)	0.583	0.417	0.000
M06.01 Seronegative rheumatoid arthritis (Shoulder region)	0.583	0.417	0.000
M00.8 Arthritis and polyarthritis due to other specified bacterial agents	0.581	0.418	0.000
M00.2 Other streptococcal arthritis and polyarthritis	0.581	0.418	0.000
M00.1 Pneumococcal arthritis and polyarthritis	0.581	0.418	0.000
M00.0 Staphylococcal arthritis and polyarthritis	0.581	0.418	0.000
E14.1 With ketoacidosis	0.580	0.420	0.000
M12.39 Palindromic rheumatism (Site unspecified)	0.579	0.421	0.000
M76.0 Gluteal tendinitis	0.578	0.421	0.000
M83 Adult osteomalacia	0.573	0.427	0.000
M00.94 Pyogenic arthritis, unspecified (Hand)	0.572	0.428	0.000
E14.8 With unspecified complications	0.570	0.430	0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere	0.570	0.430	0.000
M81 Osteoporosis without pathological fracture	0.568	0.432	0.000
M42 Spinal osteochondrosis	0.566	0.434	0.000
M06.49 Inflammatory polyarthropathy (Site unspecified)	0.565	0.435	0.000
M65.97 Synovitis and tenosynovitis, unspecified (Ankle and foot)	0.563	0.437	0.000
E14.7 With multiple complications	0.562	0.438	0.000
E14.5 With peripheral circulatory complications	0.562	0.438	0.000
E14.2 Withrenal complications	0.562	0.438	0.000
E14.0 With coma	0.562	0.438	0.000
M66.24 Spontaneous rupture of extensor tendons (Hand)	0.562	0.438	0.000
M41.94 Scoliosis, unspecified (Thoracic region)	0.561	0.439	0.000
M77.4 Metatarsalgia	0.559	0.441	0.000
E14.4 With neurological complications	0.557	0.443	0.000
M06.00 Seronegative rheumatoid arthritis (Multiple sites)	0.557	0.443	0.000
M14.8 Arthropathies in other specified diseases classified elsewhere	0.557	0.443	0.000
M14.5 Arthropathies in other endocrine, nutritional and metabolic disorders	0.557	0.443	0.000
M14.4 Arthropathy in amyloidosis	0.557	0.443	0.000
M14.3 Lipoid dermatoarthritis	0.557	0.443	0.000
M14.2 Diabetic arthropathy	0.557	0.443	0.000
M14.1 Crystal arthropathy in other metabolic disorders	0.557	0.443	0.000
M14.0 Gouty arthropathy due to enzyme defects and other inherited disorders	0.557	0.443	0.000
M77.9 Enthesopathy, unspecified	0.554	0.446	0.000
M71.8 Other specified bursopathies	0.553	0.447	0.000
M63 Disorders of muscle in diseases classified elsewhere	0.552	0.447	0.000
M61 Calcification and ossification of muscle	0.552	0.447	0.000
M80.9 Unspecified osteoporosis with pathological fracture	0.550	0.450	0.000
M05.80 Other seropositive rheumatoid arthritis (Multiple sites)	0.549	0.450	0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.549	0.451	0.000
M00.90 Pyogenic arthritis, unspecified (Multiple sites)	0.547	0.453	0.000
M70.6 Trochanteric bursitis	0.547	0.453	0.000
M65.90 Synovitis and tenosynovitis, unspecified (Multiple sites)	0.544	0.456	0.000
M65.4 Radial styloid tenosynovitis [de Quervain]	0.544	0.456	0.000
M65.91 Synovitis and tenosynovitis, unspecified (Shoulder region)	0.544	0.456	0.000
M79 Other soft tissue disorders, not elsewhere classified	0.543	0.457	0.000
M41.5 Other secondary scoliosis	0.540	0.460	0.000
M00.99 Pyogenic arthritis, unspecified (Site unspecified)	0.540	0.460	0.000
M00.98 Pyogenic arthritis, unspecified (Other)	0.540	0.460	0.000
M00.97 Pyogenic arthritis, unspecified (Ankle and foot)	0.540	0.460	0.000
M00.95 Pyogenic arthritis, unspecified (Pelvic region and thigh)	0.540	0.460	0.000
M00.93 Pyogenic arthritis, unspecified (Forearm)	0.540	0.460	0.000
M00.92 Pyogenic arthritis, unspecified (Upper arm)	0.540	0.460	0.000
M41.90 Scoliosis, unspecified (Multiple sites in spine)	0.535	0.465	0.000
M41.8 Other forms of scoliosis	0.535	0.465	0.000
M72 Fibroblastic disorders	0.534	0.466	0.000
E07.9 Disorder of thyroid, unspecified	0.001	0.468	0.531
M12.24 Villonodular synovitis (pigmented) (Hand)	0.531	0.469	0.000
M80.8 Other osteoporosis with pathological fracture	0.531	0.469	0.000
M71.3 Other bursal cyst	0.531	0.469	0.000
M46.1 Sacro-iliitis, not elsewhere classified	0.530	0.470	0.000
M05.89 Other seropositive rheumatoid arthritis (Site unspecified)	0.529	0.471	0.000
M05.88 Other seropositive rheumatoid arthritis (Other)	0.529	0.471	0.000
M05.87 Other seropositive rheumatoid arthritis (Ankle and foot)	0.529	0.471	0.000
M05.86 Other seropositive rheumatoid arthritis (Lower leg)	0.529	0.471	0.000
M05.85 Other seropositive rheumatoid arthritis (Pelvic region and thigh)	0.529	0.471	0.000
M05.84 Other seropositive rheumatoid arthritis (Hand)	0.529	0.471	0.000
M05.83 Other seropositive rheumatoid arthritis (Forearm)	0.529	0.471	0.000
M05.82 Other seropositive rheumatoid arthritis (Upper arm)	0.529	0.471	0.000
M05.81 Other seropositive rheumatoid arthritis (Shoulder region)	0.529	0.471	0.000
M41.4 Neuromuscular scoliosis	0.528	0.472	0.000
M41.3 Thoracogenic scoliosis	0.528	0.472	0.000
M41.2 Other idiopathic scoliosis	0.528	0.472	0.000
M41.1 Juvenile idiopathic scoliosis	0.528	0.472	0.000
M41.0 Infantile idiopathic scoliosis	0.528	0.472	0.000
M80.5 Idiopathic osteoporosis with pathological fracture	0.527	0.473	0.000
M91 Juvenile osteochondrosis of hip and pelvis	0.525	0.475	0.000
E14.3 With ophthalmic complications	0.522	0.477	0.000
M06.48 Inflammatory polyarthropathy (Other)	0.516	0.484	0.000
M06.47 Inflammatory polyarthropathy (Ankle and foot)	0.516	0.484	0.000
M06.46 Inflammatory polyarthropathy (Lower leg)	0.516	0.484	0.000
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)	0.516	0.484	0.000
M06.44 Inflammatory polyarthropathy (Hand)	0.516	0.484	0.000
M06.43 Inflammatory polyarthropathy (Forearm)	0.516	0.484	0.000
M06.42 Inflammatory polyarthropathy (Upper arm)	0.516	0.484	0.000
M06.41 Inflammatory polyarthropathy (Shoulder region)	0.516	0.484	0.000
E05.8 Other thyrotoxicosis	0.002	0.484	0.514
M62.8 Other specified disorders of muscle	0.516	0.484	0.000
M06.19 Adult-onset Still's disease (Site unspecified)	0.514	0.486	0.000
M06.18 Adult-onset Still's disease (Other)	0.514	0.486	0.000
M06.17 Adult-onset Still's disease (Ankle and foot)	0.514	0.486	0.000
M06.16 Adult-onset Still's disease (Lower leg)	0.514	0.486	0.000
M06.15 Adult-onset Still's disease (Pelvic region and thigh)	0.514	0.486	0.000
M06.14 Adult-onset Still's disease (Hand)	0.514	0.486	0.000
M06.13 Adult-onset Still's disease (Forearm)	0.514	0.486	0.000
M06.12 Adult-onset Still's disease (Upper arm)	0.514	0.486	0.000
M06.11 Adult-onset Still's disease (Shoulder region)	0.514	0.486	0.000
M06.10 Adult-onset Still's disease (Multiple sites)	0.514	0.486	0.000
M06.29 Rheumatoid bursitis (Site unspecified)	0.514	0.486	0.000
M06.28 Rheumatoid bursitis (Other)	0.514	0.486	0.000
M06.27 Rheumatoid bursitis (Ankle and foot)	0.514	0.486	0.000
M06.26 Rheumatoid bursitis (Lower leg)	0.514	0.486	0.000
M06.25 Rheumatoid bursitis (Pelvic region and thigh)	0.514	0.486	0.000
M06.24 Rheumatoid bursitis (Hand)	0.514	0.486	0.000
M06.23 Rheumatoid bursitis (Forearm)	0.514	0.486	0.000
M06.22 Rheumatoid bursitis (Upper arm)	0.514	0.486	0.000
M06.21 Rheumatoid bursitis (Shoulder region)	0.514	0.486	0.000
M06.20 Rheumatoid bursitis (Multiple sites)	0.514	0.486	0.000
M06.89 Other specified rheumatoid arthritis (Site unspecified)	0.514	0.486	0.000
M06.88 Other specified rheumatoid arthritis (Other)	0.514	0.486	0.000
M06.87 Other specified rheumatoid arthritis (Ankle and foot)	0.514	0.486	0.000
M06.86 Other specified rheumatoid arthritis (Lower leg)	0.514	0.486	0.000
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)	0.514	0.486	0.000
M06.84 Other specified rheumatoid arthritis (Hand)	0.514	0.486	0.000
M06.83 Other specified rheumatoid arthritis (Forearm)	0.514	0.486	0.000
M06.82 Other specified rheumatoid arthritis (Upper arm)	0.514	0.486	0.000
M06.81 Other specified rheumatoid arthritis (Shoulder region)	0.514	0.486	0.000
M06.80 Other specified rheumatoid arthritis (Multiple sites)	0.514	0.486	0.000
M08.9 Juvenile arthritis, unspecified	0.514	0.486	0.000
M08.8 Other juvenile arthritis	0.514	0.486	0.000
M08.4 Pauciarticular juvenile arthritis	0.514	0.486	0.000
M08.3 Juvenile polyarthritis (seronegative)	0.514	0.486	0.000
M08.2 Juvenile arthritis with systemic onset	0.514	0.486	0.000
M08.1 Juvenile ankylosing spondylitis	0.514	0.486	0.000
M08.0 Juvenile rheumatoid arthritis	0.514	0.486	0.000
M09.8 Juvenile arthritis in other diseases classified elsewhere	0.514	0.486	0.000
M09.2 Juvenile arthritis in ulcerative colitis	0.514	0.486	0.000
M09.1 Juvenile arthritis in Crohn's disease [regional enteritis]	0.514	0.486	0.000
M09.0 Juvenile arthritis in psoriasis	0.514	0.486	0.000
M05.09 Felty's syndrome (Site unspecified)	0.514	0.486	0.000
M05.08 Felty's syndrome (Other)	0.514	0.486	0.000
M05.07 Felty's syndrome (Ankle and foot)	0.514	0.486	0.000
M05.06 Felty's syndrome (Lower leg)	0.514	0.486	0.000
M05.05 Felty's syndrome (Pelvic region and thigh)	0.514	0.486	0.000
M05.04 Felty's syndrome (Hand)	0.514	0.486	0.000
M05.03 Felty's syndrome (Forearm)	0.514	0.486	0.000
M05.02 Felty's syndrome (Upper arm)	0.514	0.486	0.000
M05.01 Felty's syndrome (Shoulder region)	0.514	0.486	0.000
M05.00 Felty's syndrome (Multiple sites)	0.514	0.486	0.000
M05.19 Rheumatoid lung disease (Site unspecified)	0.514	0.486	0.000
M05.18 Rheumatoid lung disease (Other)	0.514	0.486	0.000
M05.17 Rheumatoid lung disease (Ankle and foot)	0.514	0.486	0.000
M05.16 Rheumatoid lung disease (Lower leg)	0.514	0.486	0.000
M05.15 Rheumatoid lung disease (Pelvic region and thigh)	0.514	0.486	0.000
M05.14 Rheumatoid lung disease (Hand)	0.514	0.486	0.000
M05.13 Rheumatoid lung disease (Forearm)	0.514	0.486	0.000
M05.12 Rheumatoid lung disease (Upper arm)	0.514	0.486	0.000
M05.11 Rheumatoid lung disease (Shoulder region)	0.514	0.486	0.000
M05.10 Rheumatoid lung disease (Multiple sites)	0.514	0.486	0.000
M05.29 Rheumatoid vasculitis (Site unspecified)	0.514	0.486	0.000
M05.28 Rheumatoid vasculitis (Other)	0.514	0.486	0.000
M05.27 Rheumatoid vasculitis (Ankle and foot)	0.514	0.486	0.000
M05.26 Rheumatoid vasculitis (Lower leg)	0.514	0.486	0.000
M05.25 Rheumatoid vasculitis (Pelvic region and thigh)	0.514	0.486	0.000
M05.24 Rheumatoid vasculitis (Hand)	0.514	0.486	0.000
M05.23 Rheumatoid vasculitis (Forearm)	0.514	0.486	0.000
M05.22 Rheumatoid vasculitis (Upper arm)	0.514	0.486	0.000
M05.21 Rheumatoid vasculitis (Shoulder region)	0.514	0.486	0.000
M05.20 Rheumatoid vasculitis (Multiple sites)	0.514	0.486	0.000
M05.39 Rheumatoid arthritis with involvement of other organs and systems (Site unspecified)	0.514	0.486	0.000
M05.38 Rheumatoid arthritis with involvement of other organs and systems (Other)	0.514	0.486	0.000
M05.37 Rheumatoid arthritis with involvement of other organs and systems (Ankle and foot)	0.514	0.486	0.000
M05.36 Rheumatoid arthritis with involvement of other organs and systems (Lower leg)	0.514	0.486	0.000
M05.35 Rheumatoid arthritis with involvement of other organs and systems (Pelvic region and thigh)	0.514	0.486	0.000
M05.34 Rheumatoid arthritis with involvement of other organs and systems (Hand)	0.514	0.486	0.000
M05.33 Rheumatoid arthritis with involvement of other organs and systems (Forearm)	0.514	0.486	0.000
M05.32 Rheumatoid arthritis with involvement of other organs and systems (Upper arm)	0.514	0.486	0.000
M05.31 Rheumatoid arthritis with involvement of other organs and systems (Shoulder region)	0.514	0.486	0.000
M05.30 Rheumatoid arthritis with involvement of other organs and systems (Multiple sites)	0.514	0.486	0.000
M76.9 Enthesopathy of lower limb, unspecified	0.514	0.486	0.000
M76.7 Peroneal tendinitis	0.514	0.486	0.000
M76.4 Tibial collateral bursitis [Pellegrini-Stieda]	0.514	0.486	0.000
M76.3 Iliotibial band syndrome	0.514	0.486	0.000
M76.2 Iliac crest spur	0.514	0.486	0.000
M76.1 Psoas tendinitis	0.514	0.486	0.000
M82.11 Osteoporosis in endocrine disorders (Shoulder region)	0.513	0.487	0.000
M65.1 Other infective (teno)synovitis	0.513	0.487	0.000
M00.91 Pyogenic arthritis, unspecified (Shoulder region)	0.512	0.488	0.000
M73.8 Other soft tissue disorders in diseases classified elsewhere	0.512	0.488	0.000
M73.1 Syphilitic bursitis	0.512	0.488	0.000
M73.0 Gonococcal bursitis	0.512	0.488	0.000
M75.81 Other shoulder lesions, right shoulder	0.511	0.489	0.000
E11.1 With ketoacidosis	0.511	0.489	0.000
M70.2 Olecranon bursitis	0.511	0.489	0.000
M92.7 Juvenile osteochondrosis of metatarsus	0.510	0.490	0.000
M46.3 Infection of intervertebral disk (pyogenic)	0.508	0.492	0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.012	0.493	0.495
E00 Congenital iodine-deficiency syndrome	0.012	0.493	0.495
M60 Myositis	0.506	0.494	0.000
M76.5 Patellar tendinitis	0.505	0.495	0.000
M70.3 Other bursitis of elbow	0.505	0.495	0.000
M71.9 Bursopathy, unspecified	0.505	0.495	0.000
M71.5 Other bursitis, not elsewhere classified	0.505	0.495	0.000
M71.4 Calcium deposit in bursa	0.505	0.495	0.000
M71.0 Abscess of bursa	0.505	0.495	0.000
M84 Disorders of continuity of bone	0.504	0.496	0.000
M13 Other arthritis	0.504	0.496	0.000
M49.59 Collapsed vertebra in diseases classified elsewhere (Site unspecified)	0.503	0.496	0.000
M49.58 Collapsed vertebra in diseases classified elsewhere (Sacral and sacrococcygeal region)	0.503	0.496	0.000
M49.57 Collapsed vertebra in diseases classified elsewhere (Lumbosacral region)	0.503	0.496	0.000
M49.55 Collapsed vertebra in diseases classified elsewhere (Thoracolumbar region)	0.503	0.496	0.000
M49.53 Collapsed vertebra in diseases classified elsewhere (Cervicothoracic region)	0.503	0.496	0.000
M49.52 Collapsed vertebra in diseases classified elsewhere (Cervical region)	0.503	0.496	0.000
M49.51 Collapsed vertebra in diseases classified elsewhere (Occipito-atlanto-axial region)	0.503	0.496	0.000
M49.50 Collapsed vertebra in diseases classified elsewhere (Multiple sites in spine)	0.503	0.496	0.000
M70.9 Unspecified soft tissue disorder related to use, overuse and pressure	0.499	0.501	0.000
M70.8 Other soft tissue disorders related to use, overuse and pressure	0.499	0.501	0.000
M70.1 Bursitis of hand	0.499	0.501	0.000
M70.0 Chronic crepitant synovitis of hand and wrist	0.499	0.501	0.000
M41.98 Scoliosis, unspecified (Sacral and sacrococcygeal region)	0.499	0.501	0.000
M41.97 Scoliosis, unspecified (Lumbosacral region)	0.499	0.501	0.000
M41.93 Scoliosis, unspecified (Cervicothoracic region)	0.499	0.501	0.000
M41.92 Scoliosis, unspecified (Cervical region)	0.499	0.501	0.000
M41.91 Scoliosis, unspecified (Occipito-atlanto-axial region)	0.499	0.501	0.000
E11.8 With unspecified complications	0.498	0.502	0.000
M76.8 Other enthesopathies of lower limb, excluding foot	0.497	0.502	0.000
M41.99 Scoliosis, unspecified (Site unspecified)	0.497	0.503	0.000
M12.38 Palindromic rheumatism (Other)	0.493	0.507	0.000
M12.37 Palindromic rheumatism (Ankle and foot)	0.493	0.507	0.000
M12.36 Palindromic rheumatism (Lower leg)	0.493	0.507	0.000
M12.35 Palindromic rheumatism (Pelvic region and thigh)	0.493	0.507	0.000
M12.34 Palindromic rheumatism (Hand)	0.493	0.507	0.000
M12.33 Palindromic rheumatism (Forearm)	0.493	0.507	0.000
M12.32 Palindromic rheumatism (Upper arm)	0.493	0.507	0.000
M12.31 Palindromic rheumatism (Shoulder region)	0.493	0.507	0.000
M12.30 Palindromic rheumatism (Multiple sites)	0.493	0.507	0.000
M46.8 Other specified inflammatory spondylopathies	0.492	0.508	0.000
M46.5 Other infective spondylopathies	0.492	0.508	0.000
M46.2 Osteomyelitis of vertebra	0.492	0.508	0.000
M46.0 Spinal enthesopathy	0.492	0.508	0.000
M41.95 Scoliosis, unspecified (Thoracolumbar region)	0.492	0.508	0.000
M77.8 Other enthesopathies, not elsewhere classified	0.491	0.509	0.000
M77.3 Calcaneal spur	0.491	0.509	0.000
M77.2 Periarthritis of wrist	0.491	0.509	0.000
E11.7 With multiple complications	0.488	0.512	0.000
M49.56 Collapsed vertebra in diseases classified elsewhere (Lumbar region)	0.487	0.512	0.000
M65.2 Calcific tendinitis	0.485	0.515	0.000
M65.0 Abscess of tendon sheath	0.485	0.515	0.000
J33.0 Polyp of nasal cavity	0.485	0.515	0.000
M82.8 Osteoporosis in other diseases classified elsewhere	0.484	0.516	0.000
M82.0 Osteoporosis in multiple myelomatosis	0.484	0.516	0.000
M82.3 Osteoporosis in diseases classified elsewhere, Forearm	0.484	0.516	0.000
M80.4 Drug-induced osteoporosis with pathological fracture	0.483	0.516	0.000
M80.3 Postsurgical malabsorption osteoporosis with pathological fracture	0.483	0.516	0.000
M80.2 Osteoporosis of disuse with pathological fracture	0.483	0.516	0.000
M40 Kyphosis and lordosis	0.483	0.517	0.000
E05.5 Thyroid crisis or storm	0.002	0.518	0.480
E05.4 Thyrotoxicosis factitia	0.002	0.518	0.480
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.002	0.518	0.480
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.002	0.518	0.480
M76.05 Gluteal tendinitis (Pelvic region and thigh)	0.480	0.520	0.000
M02.3 Reiter's disease	0.479	0.521	0.000
E13.9 Without complications	0.479	0.521	0.000
M66.5 Spontaneous rupture of unspecified tendon	0.479	0.521	0.000
M66.1 Rupture of synovium	0.479	0.521	0.000
M71.1 Other infective bursitis	0.479	0.521	0.000
M81.4 Drug-induced osteoporosis	0.479	0.521	0.000
M79.0 Rheumatism, unspecified	0.478	0.522	0.000
M46.4 Discitis, unspecified	0.478	0.522	0.000
M66.3 Spontaneous rupture of flexor tendons	0.478	0.522	0.000
E02 Subclinical iodine-deficiency hypothyroidism	0.013	0.524	0.463
M70.4 Prepatellar bursitis	0.476	0.524	0.000
M62.1 Other rupture of muscle (nontraumatic)	0.476	0.524	0.000
M12.29 Villonodular synovitis (pigmented) (Site unspecified)	0.473	0.527	0.000
M12.28 Villonodular synovitis (pigmented) (Other)	0.473	0.527	0.000
M12.27 Villonodular synovitis (pigmented) (Ankle and foot)	0.473	0.527	0.000
M12.26 Villonodular synovitis (pigmented) (Lower leg)	0.473	0.527	0.000
M12.25 Villonodular synovitis (pigmented) (Pelvic region and thigh)	0.473	0.527	0.000
M12.23 Villonodular synovitis (pigmented) (Forearm)	0.473	0.527	0.000
M12.22 Villonodular synovitis (pigmented) (Upper arm)	0.473	0.527	0.000
M12.21 Villonodular synovitis (pigmented) (Shoulder region)	0.473	0.527	0.000
M12.20 Villonodular synovitis (pigmented) (Multiple sites)	0.473	0.527	0.000
M66.4 Spontaneous rupture of other tendons	0.472	0.528	0.000
M02.9 Reactive arthopathy, unspecified	0.471	0.529	0.000
M62.5 Muscle wasting and atrophy, not elsewhere classified	0.470	0.529	0.000
E11.0 With coma	0.470	0.530	0.000
M77.47 Metatarsalgia-Ankle/Foot	0.469	0.531	0.000
M07.6 Other enteropathic arthropathies	0.469	0.531	0.000
M07.5 Arthropathy in ulcerative colitis	0.469	0.531	0.000
M07.4 Arthropathy in Crohn's disease [regional enteritis]	0.469	0.531	0.000
M07.2 Psoriatic spondylitis	0.469	0.531	0.000
M07.1 Arthritis mutilans	0.469	0.531	0.000
M07.0 Distal interphalangeal psoriatic arthropathy	0.469	0.531	0.000
J33 Nasal polyp	0.469	0.531	0.000
M02.8 Other reactive arthropathies	0.468	0.532	0.000
M02.2 Postimmunisation arthropathy	0.468	0.532	0.000
M02.1 Postdysenteric arthropathy	0.468	0.532	0.000
M02.0 Arthropathy following intestinal bypass	0.468	0.532	0.000
E11.5 With peripheral circulatory complications	0.468	0.532	0.000
E11.9 Without complications	0.467	0.533	0.000
M10 Gout	0.467	0.533	0.000
M70.5 Other bursitis of knee	0.467	0.533	0.000
M80.95 Unspecified osteoporosis with pathological fracture (Pelvic region and thigh)	0.467	0.533	0.000
M65.44 Radial styloid tenosynovitis [de Quervain] (Hand)	0.467	0.533	0.000
M94 Other disorders of cartilage	0.464	0.536	0.000
M80.1 Postoophorectomy osteoporosis with pathological fracture	0.463	0.536	0.000
M80.0 Postmenopausal osteoporosis with pathological fracture	0.460	0.539	0.000
M01.8 Arthritis in other infectious and parasitic diseases classified elsewhere	0.459	0.541	0.000
M01.6 Arthritis in mycoses	0.459	0.541	0.000
M01.5 Arthritis in other viral diseases classified elsewhere	0.459	0.541	0.000
M01.4 Rubella arthritis	0.459	0.541	0.000
M01.3 Arthritis in other bacterial diseases classified elsewhere	0.459	0.541	0.000
M01.2 Arthritis in Lyme disease	0.459	0.541	0.000
M01.1 Tuberculous arthritis	0.459	0.541	0.000
M01.0 Meningococcal arthritis	0.459	0.541	0.000
M03.6 Reactive arthropathy in other diseases classified elsewhere	0.459	0.541	0.000
M03.2 Other postinfectious arthropathies in diseases classified elsewhere	0.459	0.541	0.000
M03.1 Postinfective arthropathy in syphilis	0.459	0.541	0.000
M03.0 Postmeningococcal arthritis	0.459	0.541	0.000
M79.7 Fibromyalgia	0.457	0.543	0.000
M62.6 Muscle strain	0.456	0.544	0.000
M06.40 Inflammatory polyarthropathy (Multiple sites)	0.456	0.544	0.000
M62.9 Disorder of muscle, unspecified	0.455	0.544	0.000
M62.4 Contracture of muscle	0.455	0.544	0.000
M62.3 Immobility syndrome (paraplegic)	0.455	0.544	0.000
M62.2 Ischaemic infarction of muscle	0.455	0.544	0.000
M62.0 Diastasis of muscle	0.455	0.544	0.000
M70.7 Other bursitis of hip	0.455	0.545	0.000
M76.6 Achilles tendinitis	0.455	0.545	0.000
M77.91 Enthesopathy, unspecified (Shoulder region)	0.455	0.545	0.000
E13.8 With unspecified complications	0.454	0.546	0.000
E13.7 With multiple complications	0.454	0.546	0.000
E13.6 With other specified complications	0.454	0.546	0.000
E13.5 With peripheral circulatory complications	0.454	0.546	0.000
E13.4 With neurological complications	0.454	0.546	0.000
E13.3 With ophthalmic complications	0.454	0.546	0.000
E13.2 With renal complications	0.454	0.546	0.000
E13.1 With ketoacidosis	0.454	0.546	0.000
E13.0 With coma	0.454	0.546	0.000
M77.96 Enthesopathy, unspecified (Lower leg)	0.449	0.551	0.000
J33.8 Other polyp of sinus	0.449	0.551	0.000
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)	0.448	0.552	0.000
M92.6 Juvenile osteochondrosis of tarsus	0.447	0.553	0.000
M82.10 Osteoporosis in endocrine disorders (Multiple sites)	0.445	0.555	0.000
M71.81 Other specified bursopathies (Shoulder region)	0.444	0.556	0.000
M93 Other osteochondropathies	0.443	0.556	0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.002	0.557	0.441
E11.6 With other specified complications	0.443	0.557	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations