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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs4864469
log Bayes Factor = 13.6938
Chromosome 4   position 54,413,304  (GRCh37) Explore rs4864469 on Ensembl!
Variant rs4864469 is part of Cluster X0123

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter V Mental and behavioural disorders
0.999 0.001 0.000
S60-S69 Injuries to the wrist and hand
0.999 0.001 0.000
Chapter IX Diseases of the circulatory system
0.998 0.002 0.000
Chapter X Diseases of the respiratory system
0.997 0.003 0.000
J40-J47 Chronic lower respiratory diseases
0.996 0.004 0.000
I60-I69 Cerebrovascular diseases
0.995 0.005 0.000
J44 Other chronic obstructive pulmonary disease
0.995 0.005 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.994 0.006 0.000
Chapter XX External causes of morbidity and mortality
0.993 0.007 0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.990 0.010 0.000
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection
0.989 0.011 0.000
F10 Mental and behavioural disorders due to use of alcohol
0.989 0.011 0.000
I65.2 Occlusion and stenosis of carotid artery
0.986 0.014 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.977 0.023 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.977 0.023 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.975 0.025 0.000
S61 Open wound of wrist and hand
0.974 0.026 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.964 0.036 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.959 0.041 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.958 0.042 0.000
F10.2 Dependence syndrome
0.952 0.048 0.000
S66 Injury of muscle and tendon at wrist and hand level
0.951 0.049 0.000
S62 Fracture at wrist and hand level
0.950 0.050 0.000
Chapter VI Diseases of the nervous system
0.948 0.052 0.000
Chapter VIII Diseases of the ear and mastoid process
0.946 0.054 0.000
I84 Haemorrhoids
0.946 0.054 0.000
Chapter XI Diseases of the digestive system
0.946 0.054 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.944 0.056 0.000
K00-K14 Diseases of oral cavity, salivary glands and jaws
0.943 0.057 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.943 0.057 0.000
S61.1 Open wound of finger(s) with damage to nail
0.942 0.058 0.000
S00-S09 Injuries to the head
0.941 0.059 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.938 0.062 0.000
W00-W19 Falls
0.937 0.063 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.936 0.064 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.932 0.068 0.000
F30-F39 Mood [affective] disorders
0.930 0.070 0.000
H65-H75 Diseases of middle ear and mastoid
0.921 0.079 0.000
J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified
0.920 0.080 0.000
M20-M25 Other joint disorders
0.918 0.082 0.000
I84.6 Residual haemorrhoidal skin tags
0.915 0.085 0.000
M50-M54 Other dorsopathies
0.911 0.089 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.903 0.097 0.000
J44.9 Chronic obstructive pulmonary disease, unspecified
0.902 0.098 0.000
I69 Sequelae of cerebrovascular disease
0.900 0.100 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.899 0.101 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.896 0.104 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.894 0.105 0.000
T93 Sequelae of injuries of lower limb
0.891 0.109 0.000
S50-S59 Injuries to the elbow and forearm
0.887 0.113 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.883 0.117 0.000
M54 Dorsalgia
0.883 0.117 0.000
S40-S49 Injuries to the shoulder and upper arm
0.878 0.122 0.000
F10.1 Harmful use
0.874 0.126 0.000
I71 Aortic aneurysm and dissection
0.872 0.128 0.000
J43 Emphysema
0.872 0.128 0.000
W19 Unspecified fall
0.870 0.130 0.000
I67 Other cerebrovascular diseases
0.869 0.131 0.000
F10.3 Withdrawal state
0.869 0.131 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.868 0.132 0.000
O16 Unspecified maternal hypertension
0.867 0.133 0.000
T90 Sequelae of injuries of head
0.866 0.134 0.000
S32 Fracture of lumbar spine and pelvis
0.861 0.139 0.000
J00-J06 Acute upper respiratory infections
0.859 0.141 0.000
K13 Other diseases of lip and oral mucosa
0.858 0.142 0.000
Y43 Primarily systemic agents
0.854 0.146 0.000
G90-G99 Other disorders of the nervous system
0.849 0.151 0.000
K05 Gingivitis and periodontal diseases
0.849 0.151 0.000
K55-K64 Other diseases of intestines
0.845 0.155 0.000
F10.0 Acute intoxication
0.840 0.160 0.000
S00 Superficial injury of head
0.839 0.161 0.000
H72 Perforation of tympanic membrane
0.838 0.162 0.000
I77 Other disorders of arteries and arterioles
0.837 0.163 0.000
K08 Other disorders of teeth and supporting structures
0.836 0.164 0.000
I84.0 Internal thrombosed haemorrhoids
0.833 0.167 0.000
S66.1 Injury of flexor muscle and tendon of other finger at wrist and hand level
0.832 0.168 0.000
K57 Diverticular disease of intestine
0.831 0.169 0.000
R40 Somnolence, stupor and coma
0.831 0.169 0.000
F31 Bipolar affective disorder
0.827 0.173 0.000
M20 Acquired deformities of fingers and toes
0.827 0.173 0.000
F33 Recurrent depressive disorder
0.825 0.175 0.000
H65 Nonsuppurative otitis media
0.825 0.175 0.000
K57.3 Diverticular disease of large intestine without perforation or abscess
0.824 0.176 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.824 0.176 0.000
X60-X84 Intentional self-harm
0.823 0.177 0.000
I70 Atherosclerosis
0.822 0.178 0.000
I84.4 External haemorrhoids with other complications
0.818 0.182 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.816 0.184 0.000
M54.5 Low back pain
0.815 0.185 0.000
S62.6 Fracture of other finger
0.815 0.185 0.000
O42 Premature rupture of membranes
0.814 0.186 0.000
S62.5 Fracture of thumb
0.812 0.188 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.812 0.188 0.000
I62 Other nontraumatic intracranial haemorrhage
0.811 0.189 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.810 0.190 0.000
S80-S89 Injuries to the knee and lower leg
0.809 0.191 0.000
S01 Open wound of head
0.809 0.191 0.000
Y40 Systemic antibiotics
0.807 0.193 0.000
Chapter II Neoplasms
0.806 0.194 0.000
J42 Unspecified chronic bronchitis
0.805 0.195 0.000
K04 Diseases of pulp and periapical tissues
0.804 0.196 0.000
F41 Other anxiety disorders
0.803 0.197 0.000
W19.4 Street and highway
0.801 0.199 0.000
I73 Other peripheral vascular diseases
0.800 0.200 0.000
K06 Other disorders of gingiva and edentulous alveolar ridge
0.799 0.201 0.000
F70-F79 Mental retardation
0.799 0.201 0.000
M25 Other joint disorders, not elsewhere classified
0.799 0.201 0.000
S20-S29 Injuries to the thorax
0.796 0.204 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.794 0.206 0.000
K13.7 Other and unspecified lesions of oral mucosa
0.791 0.209 0.000
M54.1 Radiculopathy
0.790 0.210 0.000
R20 Disturbances of skin sensation
0.789 0.211 0.000
I86 Varicose veins of other sites
0.788 0.212 0.000
H66 Suppurative and unspecified otitis media
0.787 0.213 0.000
O13 Gestational [pregnancy-induced] hypertension without significant proteinuria
0.787 0.213 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.785 0.215 0.000
J43.9 Emphysema, unspecified
0.782 0.218 0.000
S30 Superficial injury of abdomen, lower back and pelvis
0.782 0.218 0.000
W20-W49 Exposure to inanimate mechanical forces
0.781 0.219 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.781 0.219 0.000
S61.7 Multiple open wounds of wrist and hand
0.781 0.219 0.000
S66.2 Injury of extensor muscle and tendon of thumb at wrist and hand level
0.779 0.221 0.000
J46 Status asthmaticus
0.779 0.221 0.000
R45 Symptoms and signs involving emotional state
0.778 0.222 0.000
K00 Disorders of tooth development and eruption
0.778 0.222 0.000
S66.3 Injury of extensor muscle and tendon of other finger at wrist and hand level
0.778 0.222 0.000
K62 Other diseases of anus and rectum
0.776 0.224 0.000
F17 Mental and behavioural disorders due to use of tobacco
0.774 0.226 0.000
O32 Maternal care for known or suspected malpresentation of foetus
0.774 0.226 0.000
M54.9 Dorsalgia, unspecified
0.772 0.228 0.000
Y43.3 Other antineoplastic drugs
0.772 0.228 0.000
K90-K93 Other diseases of the digestive system
0.771 0.229 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.770 0.230 0.000
K12 Stomatitis and related lesions
0.770 0.230 0.000
W50-W64 Exposure to animate mechanical forces
0.768 0.232 0.000
G62 Other polyneuropathies
0.768 0.232 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.767 0.233 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.766 0.234 0.000
V40-V49 Car occupant injured in transport accident
0.765 0.235 0.000
S61.8 Open wound of other parts of wrist and hand
0.765 0.235 0.000
S69 Other and unspecified injuries of wrist and hand
0.764 0.235 0.000
S00.9 Superficial injury of head, part unspecified
0.763 0.237 0.000
M20.5 Other deformities of toe(s) (acquired)
0.762 0.238 0.000
I84.8 Unspecified haemorrhoids with other complications
0.762 0.238 0.000
S62.7 Multiple fractures of fingers
0.761 0.239 0.000
R40.2 Coma, unspecified
0.761 0.239 0.000
K65-K67 Diseases of peritoneum
0.760 0.240 0.000
J03 Acute tonsillitis
0.760 0.240 0.000
S66.6 Injury of multiple flexor muscles and tendons at wrist and hand level
0.760 0.240 0.000
K05.3 Chronic periodontitis
0.760 0.240 0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.759 0.241 0.000
R47-R49 Symptoms and signs involving speech and voice
0.758 0.242 0.000
J60-J70 Lung diseases due to external agents
0.755 0.245 0.000
F41.2 Mixed anxiety and depressive disorder
0.754 0.246 0.000
F30 Manic episode
0.754 0.246 0.000
K10 Other diseases of jaws
0.753 0.247 0.000
X20-X29 Contact with venomous animals and plants
0.752 0.248 0.000
O85-O92 Complications predominantly related to the puerperium
0.752 0.248 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.752 0.248 0.000
I87 Other disorders of veins
0.751 0.249 0.000
M54.59 Low back pain (Site unspecified)
0.751 0.249 0.000
G95 Other diseases of spinal cord
0.751 0.249 0.000
M20.6 Acquired deformity of toe(s), unspecified
0.750 0.250 0.000
K62.8 Other specified diseases of anus and rectum
0.750 0.250 0.000
K62.3 Rectal prolapse
0.749 0.251 0.000
F31.9 Bipolar affective disorder, unspecified
0.749 0.251 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.749 0.251 0.000
S70-S79 Injuries to the hip and thigh
0.748 0.252 0.000
F43 Reaction to severe stress, and adjustment disorders
0.748 0.252 0.000
Q80-Q89 Other congenital malformations
0.748 0.252 0.000
G70-G73 Diseases of myoneural junction and muscle
0.746 0.253 0.000
T90.9 Sequelae of unspecified injury of head
0.746 0.254 0.000
S31 Open wound of abdomen, lower back and pelvis
0.746 0.254 0.000
R22 Localised swelling, mass and lump of skin and subcutaneous tissue
0.746 0.254 0.000
W08 Fall involving other furniture
0.745 0.255 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.745 0.255 0.000
S62.3 Fracture of other metacarpal bone
0.745 0.255 0.000
G61 Inflammatory polyneuropathy
0.744 0.256 0.000
S32.1 Fracture of sacrum
0.744 0.256 0.000
M54.56 Low back pain (Lumbar region)
0.743 0.257 0.000
T93.2 Sequelae of other fractures of lower limb
0.742 0.258 0.000
Y52 Agents primarily affecting the cardiovascular system
0.742 0.258 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.740 0.260 0.000
T93.3 Sequelae of dislocation, sprain and strain of lower limb
0.740 0.260 0.000
S32.5 Fracture of pubis
0.740 0.260 0.000
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level
0.740 0.260 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.740 0.260 0.000
O34 Maternal care for known or suspected abnormality of pelvic organs
0.739 0.261 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.739 0.261 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.739 0.261 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.738 0.262 0.000
O35 Maternal care for known or suspected foetal abnormality and damage
0.737 0.263 0.000
R46 Symptoms and signs involving appearance and behaviour
0.736 0.264 0.000
I05-I09 Chronic rheumatic heart diseases
0.736 0.264 0.000
F80-F89 Disorders of psychological development
0.735 0.265 0.000
I77.6 Arteritis, unspecified
0.735 0.265 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.735 0.265 0.000
O42.1 Premature rupture of membranes, onset of labour after 24 hours
0.735 0.265 0.000
I69.1 Sequelae of intracerebral haemorrhage
0.735 0.265 0.000
S42 Fracture of shoulder and upper arm
0.734 0.266 0.000
M51 Other intervertebral disk disorders
0.734 0.266 0.000
O14 Gestational [pregnancy-induced] hypertension with significant proteinuria
0.734 0.266 0.000
I74 Arterial embolism and thrombosis
0.733 0.267 0.000
S52 Fracture of forearm
0.732 0.267 0.000
W19.9 Unspecified place
0.732 0.268 0.000
I69.8 Sequelae of other and unspecified cerebrovascular diseases
0.732 0.268 0.000
J06 Acute upper respiratory infections of multiple and unspecified sites
0.732 0.268 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.731 0.269 0.000
I67.9 Cerebrovascular disease, unspecified
0.731 0.269 0.000
I84.5 External haemorrhoids without complication
0.730 0.270 0.000
W07 Fall involving chair
0.730 0.270 0.000
O48 Prolonged pregnancy
0.730 0.270 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.729 0.271 0.000
S51 Open wound of forearm
0.729 0.271 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.728 0.272 0.000
M80-M85 Disorders of bone density and structure
0.728 0.272 0.000
S10-S19 Injuries to the neck
0.728 0.272 0.000
T79-T79 Certain early complications of trauma
0.728 0.272 0.000
V10-V19 Pedal cyclist injured in transport accident
0.728 0.272 0.000
I81 Portal vein thrombosis
0.727 0.273 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.727 0.273 0.000
S60 Superficial injury of wrist and hand
0.727 0.273 0.000
I71.0 Dissection of aorta [any part]
0.726 0.274 0.000
T39.0 Salicylates
0.725 0.275 0.000
I82 Other venous embolism and thrombosis
0.724 0.275 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.721 0.279 0.000
M25.4 Effusion of joint
0.721 0.279 0.000
O43 Placental disorders
0.721 0.279 0.000
H72.9 Perforation of tympanic membrane, unspecified
0.720 0.280 0.000
K08.3 Retained dental root
0.719 0.281 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.718 0.282 0.000
T93.8 Sequelae of other specified injuries of lower limb
0.718 0.282 0.000
S67 Crushing injury of wrist and hand
0.718 0.282 0.000
O47 False labour
0.718 0.282 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
Y86 Sequelae of other accidents
0.717 0.283 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.716 0.283 0.000
S65 Injury of blood vessels at wrist and hand level
0.716 0.284 0.000
S64 Injury of nerves at wrist and hand level
0.716 0.284 0.000
I00-I02 Acute rheumatic fever
0.716 0.284 0.000
M34 Systemic sclerosis
0.715 0.285 0.000
I84.3 External thrombosed haemorrhoids
0.715 0.285 0.000
R93 Abnormal findings on diagnostic imaging of other body structures
0.715 0.285 0.000
M54.99 Dorsalgia, unspecified (Site unspecified)
0.714 0.286 0.000
J41 Simple and mucopurulent chronic bronchitis
0.714 0.286 0.000
K04.6 Periapical abscess with sinus
0.714 0.286 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.714 0.286 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.714 0.286 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.714 0.286 0.000
I70.2 Atherosclerosis of arteries of the extremities
0.713 0.287 0.000
S90-S99 Injuries to the ankle and foot
0.713 0.287 0.000
F19 Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances
0.713 0.287 0.000
F18 Mental and behavioural disorders due to use of volatile solvents
0.713 0.287 0.000
F16 Mental and behavioural disorders due to use of hallucinogens
0.713 0.287 0.000
F15 Mental and behavioural disorders due to use of other stimulants, including caffeine
0.713 0.287 0.000
F14 Mental and behavioural disorders due to use of cocaine
0.713 0.287 0.000
F13 Mental and behavioural disorders due to use of sedatives or hypnotics
0.713 0.287 0.000
F12 Mental and behavioural disorders due to use of cannabinoids
0.713 0.287 0.000
F11 Mental and behavioural disorders due to use of opioids
0.713 0.287 0.000
M31 Other necrotising vasculopathies
0.712 0.288 0.000
Y35-Y36 Legal intervention and operations of war
0.712 0.288 0.000
Y10-Y34 Event of undetermined intent
0.712 0.288 0.000
Y00-Y09 Assault
0.712 0.288 0.000
X85-X99 Assault
0.712 0.288 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.712 0.288 0.000
X50-X57 Overexertion, travel and privation
0.712 0.288 0.000
X30-X39 Exposure to forces of nature
0.712 0.288 0.000
X10-X19 Contact with heat and hot substances
0.712 0.288 0.000
X00-X09 Exposure to smoke, fire and flames
0.712 0.288 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.712 0.288 0.000
W75-W84 Other accidental threats to breathing
0.712 0.288 0.000
W65-W74 Accidental drowning and submersion
0.712 0.288 0.000
V98-V99 Other and unspecified transport accidents
0.712 0.288 0.000
V95-V97 Air and space transport accidents
0.712 0.288 0.000
V90-V94 Water transport accidents
0.712 0.288 0.000
V70-V79 Bus occupant injured in transport accident
0.712 0.288 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.712 0.288 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.712 0.288 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.712 0.288 0.000
V01-V09 Pedestrian injured in transport accident
0.712 0.288 0.000
J81 Pulmonary oedema
0.712 0.288 0.000
O44 Placenta praevia
0.711 0.289 0.000
I84.7 Unspecified thrombosed haemorrhoids
0.710 0.289 0.000
H69 Other disorders of Eustachian tube
0.710 0.290 0.000
I65.9 Occlusion and stenosis of unspecified precerebral artery
0.710 0.290 0.000
I65.8 Occlusion and stenosis of other precerebral artery
0.710 0.290 0.000
I65.3 Occlusion and stenosis of multiple and bilateral precerebral arteries
0.710 0.290 0.000
I65.1 Occlusion and stenosis of basilar artery
0.710 0.290 0.000
I65.0 Occlusion and stenosis of vertebral artery
0.710 0.290 0.000
Q50-Q56 Congenital malformations of genital organs
0.710 0.290 0.000
F10.9 Unspecified mental and behavioural disorder
0.709 0.291 0.000
F10.8 Other mental and behavioural disorders
0.709 0.291 0.000
F10.7 Residual and late-onset psychotic disorder
0.709 0.291 0.000
F10.6 Amnesic syndrome
0.709 0.291 0.000
F10.5 Psychotic disorder
0.709 0.291 0.000
F10.4 Withdrawal state with delirium
0.709 0.291 0.000
M86-M90 Other osteopathies
0.707 0.292 0.000
I67.1 Cerebral aneurysm, nonruptured
0.707 0.293 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.706 0.294 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.706 0.294 0.000
G40-G47 Episodic and paroxysmal disorders
0.706 0.294 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.704 0.296 0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.704 0.296 0.000
F33.1 Recurrent depressive disorder, current episode moderate
0.703 0.297 0.000
M60-M63 Disorders of muscles
0.703 0.297 0.000
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction
0.702 0.298 0.000
S62.8 Fracture of other and unspecified parts of wrist and hand
0.701 0.299 0.000
T90.2 Sequelae of fracture of skull and facial bones
0.701 0.299 0.000
R41 Other symptoms and signs involving cognitive functions and awareness
0.700 0.300 0.000
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified
0.700 0.300 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.700 0.300 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.700 0.300 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.700 0.300 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.700 0.300 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.700 0.300 0.000
T36 Poisoning by systemic antibiotics
0.700 0.300 0.000
R29 Other symptoms and signs involving the nervous and musculoskeletal systems
0.700 0.300 0.000
H74 Other disorders of middle ear and mastoid
0.700 0.300 0.000
V80-V89 Other land transport accidents
0.700 0.300 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.699 0.301 0.000
S61.9 Open wound of wrist and hand, part unspecified
0.699 0.301 0.000
Y57 Other and unspecified drugs and medicaments
0.698 0.302 0.000
S05 Injury of eye and orbit
0.697 0.303 0.000
R20.8 Other and unspecified disturbances of skin sensation
0.697 0.303 0.000
H65.3 Chronic mucoid otitis media
0.697 0.303 0.000
R93.3 Abnormal findings on diagnostic imaging of other parts of digestive tract
0.697 0.303 0.000
I78 Diseases of capillaries
0.697 0.303 0.000
M22 Disorders of patella
0.696 0.304 0.000
F60-F69 Disorders of adult personality and behaviour
0.696 0.304 0.000
K06.8 Other specified disorders of gingiva and edentulous alveolar ridge
0.696 0.304 0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.696 0.304 0.000
J95-J99 Other diseases of the respiratory system
0.696 0.304 0.000
G95.9 Disease of spinal cord, unspecified
0.695 0.305 0.000
S09 Other and unspecified injuries of head
0.695 0.305 0.000
M23 Internal derangement of knee
0.694 0.306 0.000
G30-G32 Other degenerative diseases of the nervous system
0.693 0.307 0.000
S61.0 Open wound of finger(s) without damage to nail
0.692 0.308 0.000
T39.1 4-Aminophenol derivatives
0.692 0.308 0.000
I72 Other aneurysm
0.692 0.308 0.000
I88 Nonspecific lymphadenitis
0.691 0.308 0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.691 0.309 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.690 0.309 0.000
M40-M43 Deforming dorsopathies
0.690 0.310 0.000
J03.9 Acute tonsillitis, unspecified
0.690 0.310 0.000
M53 Other dorsopathies, not elsewhere classified
0.689 0.310 0.000
C34 Malignant neoplasm of bronchus and lung
0.689 0.311 0.000
T98 Sequelae of other and unspecified effects of external causes
0.688 0.312 0.000
T95 Sequelae of burns, corrosions and frostbite
0.688 0.312 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.688 0.312 0.000
T91 Sequelae of injuries of neck and trunk
0.688 0.312 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.688 0.312 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.688 0.312 0.000
Y59 Other and unspecified vaccines and biological substances
0.687 0.313 0.000
Y58 Bacterial vaccines
0.687 0.313 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.687 0.313 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.687 0.313 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.687 0.313 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.687 0.313 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.687 0.313 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.687 0.313 0.000
Y48 Anaesthetics and therapeutic gases
0.687 0.313 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.687 0.313 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.687 0.313 0.000
O60-O75 Complications of labour and delivery
0.686 0.314 0.000
T93.9 Sequelae of unspecified injury of lower limb
0.686 0.314 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.686 0.314 0.000
S52.6 Fracture of lower end of both ulna and radius
0.686 0.314 0.000
K01 Embedded and impacted teeth
0.686 0.314 0.000
Y44 Agents primarily affecting blood constituents
0.685 0.315 0.000
J44.8 Other specified chronic obstructive pulmonary disease
0.685 0.315 0.000
S80 Superficial injury of lower leg
0.685 0.315 0.000
I67.0 Dissection of cerebral arteries, nonruptured
0.685 0.315 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.685 0.315 0.000
H72.8 Other perforations of tympanic membrane
0.684 0.316 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.684 0.316 0.000
V20-V29 Motorcycle rider injured in transport accident
0.683 0.316 0.000
R92 Abnormal findings on diagnostic imaging of breast
0.682 0.318 0.000
M91-M94 Chondropathies
0.682 0.318 0.000
S66.9 Injury of unspecified muscle and tendon at wrist and hand level
0.682 0.318 0.000
S66.8 Injury of other muscles and tendons at wrist and hand level
0.682 0.318 0.000
S66.7 Injury of multiple extensor muscles and tendons at wrist and hand level
0.682 0.318 0.000
S66.5 Injury of intrinsic muscle and tendon of other finger at wrist and hand level
0.682 0.318 0.000
S66.4 Injury of intrinsic muscle and tendon of thumb at wrist and hand level
0.682 0.318 0.000
S66.0 Injury of long flexor muscle and tendon of thumb at wrist and hand level
0.682 0.318 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.682 0.318 0.000
O41 Other disorders of amniotic fluid and membranes
0.681 0.318 0.000
S62.4 Multiple fractures of metacarpal bones
0.681 0.319 0.000
S62.2 Fracture of first metacarpal bone
0.681 0.319 0.000
S62.1 Fracture of other carpal bone(s)
0.681 0.319 0.000
S62.0 Fracture of navicular [scaphoid] bone of hand
0.681 0.319 0.000
R45.8 Other symptoms and signs involving emotional state
0.681 0.319 0.000
M21 Other acquired deformities of limbs
0.680 0.320 0.000
W02 Fall involving ice-skates, skis, roller-skates or skateboards
0.680 0.320 0.000
K11 Diseases of salivary glands
0.679 0.320 0.000
S02 Fracture of skull and facial bones
0.679 0.321 0.000
G91 Hydrocephalus
0.679 0.321 0.000
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle
0.678 0.322 0.000
S62.61 Fracture of other finger (open)
0.677 0.322 0.000
F40 Phobic anxiety disorders
0.677 0.323 0.000
F99-F99 Unspecified mental disorder
0.677 0.323 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.677 0.323 0.000
M00-M03 Infectious arthropathies
0.677 0.323 0.000
T51 Toxic effect of alcohol
0.676 0.323 0.000
K03 Other diseases of hard tissues of teeth
0.676 0.324 0.000
S50 Superficial injury of forearm
0.676 0.324 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.676 0.324 0.000
H66.9 Otitis media, unspecified
0.675 0.325 0.000
S08 Traumatic amputation of part of head
0.675 0.325 0.000
S07 Crushing injury of head
0.675 0.325 0.000
S04 Injury of cranial nerves
0.675 0.325 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.675 0.325 0.000
I69.3 Sequelae of cerebral infarction
0.675 0.325 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.674 0.326 0.000
S62.50 Fracture of thumb (closed)
0.674 0.326 0.000
O40 Polyhydramnios
0.673 0.327 0.000
S38 Crushing injury and traumatic amputation of part of abdomen, lower back and pelvis
0.673 0.327 0.000
S37 Injury of urinary and pelvic organs
0.673 0.327 0.000
S36 Injury of intra-abdominal organs
0.673 0.327 0.000
S35 Injury of blood vessels at abdomen, lower back and pelvis level
0.673 0.327 0.000
S34 Injury of nerves and lumbar spinal cord at abdomen, lower back and pelvis level
0.673 0.327 0.000
S33 Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis
0.673 0.327 0.000
S30.8 Other superficial injuries of abdomen, lower back and pelvis
0.673 0.327 0.000
Q60-Q64 Congenital malformations of the urinary system
0.672 0.327 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.672 0.328 0.000
J47 Bronchiectasis
0.672 0.328 0.000
H90-H95 Other disorders of ear
0.672 0.328 0.000
W18 Other fall on same level
0.672 0.328 0.000
W17 Other fall from one level to another
0.672 0.328 0.000
W16 Diving or jumping into water causing injury other than drowning or submersion
0.672 0.328 0.000
W15 Fall from cliff
0.672 0.328 0.000
W14 Fall from tree
0.672 0.328 0.000
W12 Fall on and from scaffolding
0.672 0.328 0.000
W11 Fall on and from ladder
0.672 0.328 0.000
W10 Fall on and from stairs and steps
0.672 0.328 0.000
W09 Fall involving playground equipment
0.672 0.328 0.000
W06 Fall involving bed
0.672 0.328 0.000
W05 Fall involving wheelchair
0.672 0.328 0.000
W04 Fall while being carried or supported by other persons
0.672 0.328 0.000
W03 Other fall on same level due to collision with, or pushing by, another person
0.672 0.328 0.000
W01 Fall on same level from slipping, tripping and stumbling
0.672 0.328 0.000
W00 Fall on same level involving ice and snow
0.672 0.328 0.000
O15 Eclampsia
0.671 0.329 0.000
O12 Gestational [pregnancy-induced] oedema and proteinuria without hypertension
0.671 0.329 0.000
O10 Pre-existing hypertension complicating pregnancy, childbirth and the puerperium
0.671 0.329 0.000
O11 Pre-existing hypertensive disorder with superimposed proteinuria
0.671 0.329 0.000
S06 Intracranial injury
0.671 0.329 0.000
I69.0 Sequelae of subarachnoid haemorrhage
0.671 0.329 0.000
J40 Bronchitis, not specified as acute or chronic
0.671 0.329 0.000
R29.8 Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
0.671 0.329 0.000
Y40.9 Systemic antibiotic, unspecified
0.671 0.329 0.000
M24 Other specific joint derangements
0.671 0.329 0.000
R21 Rash and other nonspecific skin eruption
0.670 0.330 0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.670 0.330 0.000
I89 Other non-infective disorders of lymphatic vessels and lymph nodes
0.669 0.331 0.000
K92 Other diseases of digestive system
0.669 0.331 0.000
O45 Premature separation of placenta [abruptio placentae]
0.668 0.332 0.000
O33 Maternal care for known or suspected disproportion
0.668 0.332 0.000
O31 Complications specific to multiple gestation
0.668 0.332 0.000
I86.4 Gastric varices
0.668 0.332 0.000
M25.46 Effusion of joint (Lower leg)
0.668 0.332 0.000
K65 Peritonitis
0.668 0.332 0.000
X63 Intentional self-poisoning by and exposure to other drugs acting on the autonomic nervous system
0.667 0.332 0.000
K05.6 Periodontal disease, unspecified
0.667 0.333 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.667 0.333 0.000
F38 Other mood [affective] disorders
0.666 0.333 0.000
F34 Persistent mood [affective] disorders
0.666 0.333 0.000
F39 Unspecified mood [affective] disorder
0.666 0.333 0.000
R22.0 Localised swelling, mass and lump, head
0.666 0.334 0.000
I62.0 Subdural haemorrhage (acute) (nontraumatic)
0.666 0.334 0.000
T90.5 Sequelae of intracranial injury
0.666 0.334 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.666 0.334 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.665 0.335 0.000
S40 Superficial injury of shoulder and upper arm
0.665 0.335 0.000
F17.2 Dependence syndrome
0.665 0.335 0.000
F43.0 Acute stress reaction
0.665 0.335 0.000
M54.16 Radiculopathy (Lumbar region)
0.664 0.336 0.000
S49 Other and unspecified injuries of shoulder and upper arm
0.664 0.336 0.000
O46 Antepartum haemorrhage, not elsewhere classified
0.662 0.338 0.000
M25.3 Other instability of joint
0.661 0.338 0.000
H80-H83 Diseases of inner ear
0.661 0.339 0.000
S32.10 Fracture of sacrum (closed)
0.660 0.340 0.000
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere
0.660 0.340 0.000
H70 Mastoiditis and related conditions
0.660 0.340 0.000
H68 Eustachian salpingitis and obstruction
0.660 0.340 0.000
H67 Otitis media in diseases classified elsewhere
0.660 0.340 0.000
K00.6 Disturbances in tooth eruption
0.659 0.341 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.658 0.342 0.000
M33 Dermatopolymyositis
0.658 0.342 0.000
M32 Systemic lupus erythematosus
0.658 0.342 0.000
M30 Polyarteritis nodosa and related conditions
0.658 0.342 0.000
G90 Disorders of autonomic nervous system
0.658 0.342 0.000
K09 Cysts of oral region, not elsewhere classified
0.657 0.343 0.000
H72.0 Central perforation of tympanic membrane
0.657 0.343 0.000
J90-J94 Other diseases of pleura
0.656 0.344 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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