TreeWAS – Variant ID: rs6058339

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability
C44 Other malignant neoplasms of skin	1.000	0.000
L80-L99 Other disorders of the skin and subcutaneous tissue	1.000	0.000
C44.6 Skin of upper limb, including shoulder	1.000	0.000
Chapter XII Diseases of the skin and subcutaneous tissue	1.000	0.000
C43-C44 Melanoma and other malignant neoplasms of skin	1.000	0.000
C44.3 Skin of other and unspecified parts of face	1.000	0.000
C44.5 Skin of trunk	1.000	0.000
L90 Atrophic disorders of skin	1.000	0.000
L90.5 Scar conditions and fibrosis of skin	0.999	0.001
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue	0.999	0.001
L57 Skin changes due to chronic exposure to nonionising radiation	0.999	0.001
L57.0 Actinic keratosis	0.998	0.002
M20 Acquired deformities of fingers and toes	0.998	0.002
M20.1 Hallux valgus (acquired)	0.998	0.002
M23 Internal derangement of knee	0.998	0.002
M23.2 Derangement of meniscus due to old tear or injury	0.998	0.002
L81 Other disorders of pigmentation	0.998	0.002
M20-M25 Other joint disorders	0.997	0.003
C43 Malignant melanoma of skin	0.997	0.003
C44.4 Skin of scalp and neck	0.996	0.004
M23.23 Derangement of meniscus due to old tear or injury (Medial collateral ligament or Other and unspecified medial meniscus)	0.996	0.004
C44.1 Skin of eyelid, including canthus	0.996	0.004
L81.4 Other melanin hyperpigmentation	0.995	0.005
Chapter II Neoplasms	0.989	0.011
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system	0.983	0.017
C71 Malignant neoplasm of brain	0.980	0.020
M20.4 Other hammer toe(s) (acquired)	0.980	0.020
L85 Other epidermal thickening	0.979	0.021
M23.21 Derangement of meniscus due to old tear or injury (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.977	0.023
C71.9 Brain, unspecified	0.965	0.035
L60-L75 Disorders of skin appendages	0.963	0.037
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.962	0.038
L72.1 Trichilemmal cyst	0.959	0.041
L72 Follicular cysts of skin and subcutaneous tissue	0.959	0.041
L85.8 Other specified epidermal thickening	0.958	0.042
C43.6 Malignant melanoma of upper limb, including shoulder	0.953	0.047
M23.8 Other internal derangements of knee	0.942	0.058
C43.5 Malignant melanoma of trunk	0.935	0.065
C44.2 Skin of ear and external auricular canal	0.934	0.066
D37-D48 Neoplasms of uncertain or unknown behaviour	0.934	0.066
# Top node	0.931	0.069
M80-M85 Disorders of bone density and structure	0.927	0.073
D46 Myelodysplastic syndromes	0.914	0.086
M20.0 Deformity of finger(s)	0.908	0.092
C44.7 Skin of lower limb, including hip	0.908	0.092
M23.26 Derangement of meniscus due to old tear or injury (Other and unspecified lateral meniscus)	0.906	0.094
M23.81 Other internal derangements of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.899	0.101
L81.8 Other specified disorders of pigmentation	0.895	0.105
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx	0.892	0.108
C43.4 Malignant melanoma of scalp and neck	0.892	0.108
C71.0 Cerebrum, except lobes and ventricles	0.888	0.112
L50-L54 Urticaria and erythema	0.882	0.118
C44.0 Skin of lip	0.876	0.124
L83 Acanthosis nigricans	0.875	0.125
L89 Decubitus ulcer	0.872	0.128
M84 Disorders of continuity of bone	0.859	0.141
C71.2 Temporal lobe	0.853	0.147
Chapter XX External causes of morbidity and mortality	0.846	0.154
M40-M43 Deforming dorsopathies	0.841	0.159
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.836	0.164
M80 Osteoporosis with pathological fracture	0.836	0.164
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.833	0.167
C73-C75 Malignant neoplasms of thyroid and other endocrine glands	0.828	0.172
Y52 Agents primarily affecting the cardiovascular system	0.824	0.176
C43.1 Malignant melanoma of eyelid, including canthus	0.822	0.178
D46.2 Refractory anaemia with excess of blasts	0.822	0.178
M86-M90 Other osteopathies	0.821	0.179
D46.9 Myelodysplastic syndrome, unspecified	0.820	0.180
M45-M49 Spondylopathies	0.817	0.183
L59 Other disorders of skin and subcutaneous tissue related to radiation	0.815	0.185
C40-C41 Malignant neoplasms of bone and articular cartilage	0.804	0.196
Chapter VII Diseases of the eye and adnexa	0.803	0.197
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified	0.801	0.199
L57.8 Other skin changes due to chronic exposure to nonionising radiation	0.801	0.199
M23.24 Derangement of meniscus due to old tear or injury (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.796	0.204
C43.3 Malignant melanoma of other and unspecified parts of face	0.796	0.204
M23.29 Derangement of meniscus due to old tear or injury (Unspecified ligament or Unspecified meniscus)	0.794	0.206
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system	0.792	0.208
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.790	0.210
M23.4 Loose body in knee	0.790	0.210
M23.5 Chronic instability of knee	0.789	0.211
Q38-Q45 Other congenital malformations of the digestive system	0.786	0.214
Y52.5 Other antihypertensive drugs, not elsewhere classified	0.786	0.214
M91-M94 Chondropathies	0.780	0.220
D00-D09 In situ neoplasms	0.779	0.221
L50 Urticaria	0.778	0.222
H30-H36 Disorders of choroid and retina	0.774	0.226
D46.4 Refractory anaemia, unspecified	0.773	0.227
D03 Melanoma in situ	0.772	0.228
L85.1 Acquired keratosis [keratoderma] palmaris et plantaris	0.771	0.229
M85 Other disorders of bone density and structure	0.770	0.230
H34 Retinal vascular occlusions	0.767	0.233
M23.80 Other internal derangements of knee (Multiple sites)	0.764	0.236
H53-H54 Visual disturbances and blindness	0.762	0.238
C15-C26 Malignant neoplasms of digestive organs	0.759	0.241
C72 Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system	0.757	0.243
H53 Visual disturbances	0.753	0.247
L89.0 Stage I decubitus ulcer and pressure area	0.752	0.248
C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx	0.752	0.248
M60-M63 Disorders of muscles	0.751	0.249
L10-L14 Bullous disorders	0.751	0.249
L89.1 Stage II decubitus ulcer	0.747	0.253
M84.1 Nonunion of fracture [pseudarthrosis]	0.747	0.253
M23.9 Internal derangement of knee, unspecified	0.746	0.254
H34.2 Other retinal artery occlusions	0.744	0.256
C45-C49 Malignant neoplasms of mesothelial and soft tissue	0.743	0.257
M23.83 Other internal derangements of knee (Medial collateral ligament or Other and unspecified medial meniscus)	0.740	0.260
C71.4 Occipital lobe	0.737	0.263
M00-M03 Infectious arthropathies	0.735	0.265
L93 Lupus erythematosus	0.735	0.265
H53.8 Other visual disturbances	0.734	0.266
C15 Malignant neoplasm of oesophagus	0.734	0.266
D45 Polycythaemia vera	0.734	0.266
L70 Acne	0.734	0.266
L81.2 Freckles	0.732	0.268
C71.1 Frontal lobe	0.732	0.268
M40 Kyphosis and lordosis	0.732	0.268
C04 Malignant neoplasm of floor of mouth	0.730	0.270
L85.9 Epidermal thickening, unspecified	0.728	0.272
D03.3 Melanoma in situ of other and unspecified parts of face	0.728	0.272
M23.0 Cystic meniscus	0.727	0.273
Y85-Y89 Sequelae of external causes of morbidity and mortality	0.726	0.274
C50-C50 Malignant neoplasm of breast	0.725	0.275
M80.9 Unspecified osteoporosis with pathological fracture	0.725	0.275
M20.6 Acquired deformity of toe(s), unspecified	0.721	0.279
C73 Malignant neoplasm of thyroid gland	0.719	0.281
M30 Polyarteritis nodosa and related conditions	0.718	0.282
M32 Systemic lupus erythematosus	0.717	0.282
C15.5 Lower third of oesophagus	0.718	0.282
C44.8 Overlapping lesion of skin	0.717	0.283
L99 Other disorders of skin and subcutaneous tissue in diseases classified elsewhere	0.717	0.283
L87 Transepidermal elimination disorders	0.717	0.283
L88 Pyoderma gangrenosum	0.717	0.283
L86 Keratoderma in diseases classified elsewhere	0.717	0.283
L90.9 Atrophic disorder of skin, unspecified	0.717	0.283
L90.8 Other atrophic disorders of skin	0.717	0.283
L90.6 Striae atrophicae	0.717	0.283
L90.4 Acrodermatitis chronica atrophicans	0.717	0.283
L90.3 Atrophoderma of Pasini and Pierini	0.717	0.283
L90.2 Anetoderma of Jadassohn-Pellizzari	0.717	0.283
L90.1 Anetoderma of Schweninger-Buzzi	0.717	0.283
L58 Radiodermatitis	0.716	0.283
L55 Sunburn	0.716	0.283
C13 Malignant neoplasm of hypopharynx	0.716	0.284
L57.5 Actinic granuloma	0.716	0.284
L57.3 Poikiloderma of Civatte	0.716	0.284
L57.2 Cutis rhomboidalis nuchae	0.716	0.284
L57.1 Actinic reticuloid	0.716	0.284
L51 Erythema multiforme	0.716	0.284
D46.7 Other myelodysplastic syndromes	0.716	0.284
M23.27 Derangement of meniscus due to old tear or injury-Capsular	0.715	0.285
L81.7 Pigmented purpuric dermatosis	0.715	0.285
L81.6 Other disorders of diminished melanin formation	0.715	0.285
L81.5 Leukoderma, not elsewhere classified	0.715	0.285
L81.3 Cafe au lait spots	0.715	0.285
L81.1 Chloasma	0.715	0.285
L81.0 Postinflammatory hyperpigmentation	0.715	0.285
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.715	0.285
M87 Osteonecrosis	0.715	0.285
C43.8 Overlapping malignant melanoma of skin	0.714	0.285
C43.2 Malignant melanoma of ear and external auricular canal	0.714	0.285
C43.0 Malignant melanoma of lip	0.714	0.285
C71.3 Parietal lobe	0.714	0.286
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.711	0.289
C05 Malignant neoplasm of palate	0.707	0.293
H34.8 Other retinal vascular occlusions	0.705	0.295
C70 Malignant neoplasm of meninges	0.705	0.295
M84.4 Pathological fracture, not elsewhere classified	0.703	0.297
C71.7 Brain stem	0.703	0.297
C71.6 Cerebellum	0.703	0.297
C71.5 Cerebral ventricle	0.703	0.297
L85.3 Xerosis cutis	0.702	0.298
L85.2 Keratosis punctata (palmaris et plantaris)	0.702	0.298
L85.0 Acquired ichthyosis	0.702	0.298
M23.1 Discoid meniscus (congenital)	0.701	0.299
C97-C97 Malignant neoplasms of independent (primary) multiple sites	0.700	0.300
C25 Malignant neoplasm of pancreas	0.699	0.301
M48 Other spondylopathies	0.697	0.302
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue	0.696	0.304
D39 Neoplasm of uncertain or unknown behaviour of female genital organs	0.696	0.304
C43.9 Malignant melanoma of skin, unspecified	0.695	0.305
C48 Malignant neoplasm of retroperitoneum and peritoneum	0.694	0.306
Y52.2 Other antidysrhythmic drugs, not elsewhere classified	0.694	0.306
Y48 Anaesthetics and therapeutic gases	0.692	0.308
C12 Malignant neoplasm of pyriform sinus	0.691	0.309
D03.5 Melanoma in situ of trunk	0.691	0.309
L75 Apocrine sweat disorders	0.690	0.310
L74 Eccrine sweat disorders	0.690	0.310
L68 Hypertrichosis	0.690	0.310
L67 Hair colour and hair shaft abnormalities	0.690	0.310
L66 Cicatricial alopecia [scarring hair loss]	0.690	0.310
L64 Androgenic alopecia	0.690	0.310
L63 Alopecia areata	0.690	0.310
L62 Nail disorders in diseases classified elsewhere	0.690	0.310
L72.2 Steatocystoma multiplex	0.687	0.313
L72.9 Follicular cyst of skin and subcutaneous tissue, unspecified	0.687	0.313
L90.0 Lichen sclerosus et atrophicus	0.686	0.314
H35 Other retinal disorders	0.685	0.315
M33 Dermatopolymyositis	0.684	0.315
C00 Malignant neoplasm of lip	0.683	0.317
L95 Vasculitis limited to skin, not elsewhere classified	0.683	0.317
L59.9 Disorder of skin and subcutaneous tissue related to radiation, unspecified	0.683	0.317
L89.3 Stage IV decubitus ulcer	0.679	0.321
Y85 Sequelae of transport accidents	0.678	0.322
C11 Malignant neoplasm of nasopharynx	0.678	0.322
M84.2 Delayed union of fracture	0.678	0.322
D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs	0.678	0.322
H00-H06 Disorders of eyelid, lacrimal system and orbit	0.677	0.323
M43 Other deforming dorsopathies	0.677	0.323
C06 Malignant neoplasm of other and unspecified parts of mouth	0.676	0.324
M23.87 Other internal derangements of knee (Capsular ligament)	0.675	0.324
M23.86 Other internal derangements of knee (Other and unspecified lateral meniscus)	0.675	0.324
M23.85 Other internal derangements of knee (Posterior horn of lateral meniscus)	0.675	0.324
M23.84 Other internal derangements of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.675	0.324
M22 Disorders of patella	0.676	0.324
Q38 Other congenital malformations of tongue, mouth and pharynx	0.675	0.325
Y42.7 Androgens and anabolic congeners	0.674	0.326
C01 Malignant neoplasm of base of tongue	0.674	0.326
M23.59 Chronic instability of knee (Unspecified ligament or Unspecified meniscus)	0.673	0.327
C41 Malignant neoplasm of bone and articular cartilage of other and unspecified sites	0.671	0.329
D43.2 Brain, unspecified	0.671	0.329
D42 Neoplasm of uncertain or unknown behaviour of meninges	0.669	0.331
M80.1 Postoophorectomy osteoporosis with pathological fracture	0.669	0.331
L72.8 Other follicular cysts of skin and subcutaneous tissue	0.669	0.331
M21 Other acquired deformities of limbs	0.668	0.332
M94 Other disorders of cartilage	0.668	0.332
Chapter XVI Certain conditions originating in the perinatal period	0.667	0.333
X10-X19 Contact with heat and hot substances	0.666	0.333
M23.49 Loose body in knee-Unspec lig/men	0.666	0.333
C21 Malignant neoplasm of anus and anal canal	0.666	0.334
Y52.9 Other and unspecified agents primarily affecting the cardiovascular system	0.665	0.334
M83 Adult osteomalacia	0.664	0.335
L65 Other nonscarring hair loss	0.664	0.336
M48.5 Collapsed vertebra, not elsewhere classified	0.663	0.337
X40-X49 Accidental poisoning by and exposure to noxious substances	0.662	0.338
Q43 Other congenital malformations of intestine	0.660	0.340
Y42.0 Glucocorticoids and synthetic analogs	0.658	0.342
C44.9 Malignant neoplasm of skin, unspecified	0.657	0.343
X20-X29 Contact with venomous animals and plants	0.656	0.344
H04 Disorders of lachrymal system	0.656	0.344
Q66 Congenital deformities of feet	0.656	0.344
D46.6 Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality	0.655	0.345
D46.5 Refractory anaemia with multi-lineage dysplasia	0.655	0.345
D46.3 Refractory anaemia with excess of blasts with transformation	0.655	0.345
D46.1 Refractory anaemia with sideroblasts	0.655	0.345
D46.0 Refractory anaemia without sideroblasts, so stated	0.655	0.345
L94 Other localised connective tissue disorders	0.655	0.345
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.655	0.345
D41 Neoplasm of uncertain or unknown behaviour of urinary organs	0.655	0.345
M90 Osteopathies in diseases classified elsewhere	0.654	0.346
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites	0.654	0.346
M80.98 Unspecified osteoporosis with pathological fracture (Other)	0.654	0.346
M34 Systemic sclerosis	0.653	0.347
M40.2 Other and unspecified kyphosis	0.653	0.347
L50.9 Urticaria, unspecified	0.653	0.347
C14.0 Pharynx, unspecified	0.652	0.348
Y52.3 Coronary vasodilators, not elsewhere classified	0.652	0.348
M84.13 Nonunion of fracture [pseudarthrosis] (Forearm)	0.651	0.349
Y52.4 Angiotensin-converting-enzyme inhibitors	0.651	0.349
M85.8 Other specified disorders of bone density and structure	0.651	0.349
C71.8 Overlapping lesion of brain	0.650	0.349
Z85.8 Personal history of malignant neoplasms of other organs and systems	0.650	0.350
M46 Other inflammatory spondylopathies	0.649	0.351
C15.9 Oesophagus, unspecified	0.649	0.351
M80.0 Postmenopausal osteoporosis with pathological fracture	0.649	0.351
D03.4 Melanoma in situ of scalp and neck	0.648	0.352
L56 Other acute skin changes due to ultraviolet radiation	0.648	0.352
C10 Malignant neoplasm of oropharynx	0.647	0.353
C25.0 Head of pancreas	0.644	0.356
W75-W84 Other accidental threats to breathing	0.644	0.356
H53.9 Visual disturbance, unspecified	0.642	0.358
L50.0 Allergic urticaria	0.641	0.359
C08 Malignant neoplasm of other and unspecified major salivary glands	0.639	0.360
C03 Malignant neoplasm of gum	0.639	0.360
M49 Spondylopathies in diseases classified elsewhere	0.639	0.361
H04.2 Epiphora	0.638	0.362
M23.6 Other spontaneous disruption of ligament(s) of knee	0.636	0.364
M84.0 Malunion of fracture	0.636	0.364
Y42.6 Antigonadotrophins, antioestrogens, antiandrogens, not elsewhere classified	0.635	0.365
Y45 Analgesics, antipyretics and anti-inflammatory drugs	0.635	0.365
Y47 Sedatives, hypnotics and antianxiety drugs	0.634	0.366
Y00-Y09 Assault	0.633	0.367
L54 Erythema in diseases classified elsewhere	0.632	0.367
M87.9 Osteonecrosis, unspecified	0.631	0.369
Y51 Drugs primarily affecting the autonomic nervous system	0.629	0.371
L53 Other erythematous conditions	0.628	0.372
X58-X59 Accidental exposure to other and unspecified factors	0.627	0.373
M45 Ankylosing spondylitis	0.626	0.373
V20-V29 Motorcycle rider injured in transport accident	0.626	0.373
M84.14 Nonunion of fracture [pseudarthrosis] (Hand)	0.626	0.374
M23.82 Other internal derangements of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.625	0.375
D03.6 Melanoma in situ of upper limb, including shoulder	0.625	0.375
Y60-Y69 Misadventures to patients during surgical and medical care	0.625	0.375
Y52.1 Calcium-channel blockers	0.625	0.375
H53.1 Subjective visual disturbances	0.624	0.376
C21.0 Anus, unspecified	0.622	0.378
Y42.5 Other oestrogens and progestogens	0.621	0.379
L57.4 Cutis laxa senilis	0.620	0.380
M88 Paget's disease of bone [osteitis deformans]	0.620	0.380
Q40 Other congenital malformations of upper alimentary tract	0.618	0.382
C22 Malignant neoplasm of liver and intrahepatic bile ducts	0.616	0.384
M84.9 Disorder of continuity of bone, unspecified	0.616	0.384
M84.8 Other disorders of continuity of bone	0.616	0.384
M84.3 Stress fracture, not elsewhere classified	0.616	0.384
Y49 Psychotropic drugs, not elsewhere classified	0.615	0.385
M24 Other specific joint derangements	0.615	0.385
C04.9 Floor of mouth, unspecified	0.614	0.386
L81.9 Disorder of pigmentation, unspecified	0.612	0.388
Y42.8 Other and unspecified hormones and their synthetic substitutes	0.611	0.389
Q66.8 Other congenital deformities of feet	0.610	0.390
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.610	0.390
C43.7 Malignant melanoma of lower limb, including hip	0.609	0.391
H53.0 Amblyopia ex anopsia	0.609	0.391
Y35-Y36 Legal intervention and operations of war	0.607	0.393
Y10-Y34 Event of undetermined intent	0.607	0.393
X85-X99 Assault	0.607	0.393
X30-X39 Exposure to forces of nature	0.607	0.393
X00-X09 Exposure to smoke, fire and flames	0.607	0.393
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure	0.607	0.393
W65-W74 Accidental drowning and submersion	0.607	0.393
V95-V97 Air and space transport accidents	0.607	0.393
V90-V94 Water transport accidents	0.607	0.393
V70-V79 Bus occupant injured in transport accident	0.607	0.393
V60-V69 Occupant of heavy transport vehicle injured in transport accident	0.607	0.393
V50-V59 Occupant of pick-up truck or van injured in transport accident	0.607	0.393
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident	0.607	0.393
C48.2 Peritoneum, unspecified	0.605	0.395
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction	0.603	0.397
M42 Spinal osteochondrosis	0.603	0.397
M84.17 Nonunion of fracture [pseudarthrosis] (Ankle and foot)	0.603	0.397
D43.0 Brain, supratentorial	0.603	0.397
Q44 Congenital malformations of gallbladder, bile ducts and liver	0.603	0.397
Q80-Q89 Other congenital malformations	0.602	0.398
D01 Carcinoma in situ of other and unspecified digestive organs	0.602	0.398
V01-V09 Pedestrian injured in transport accident	0.601	0.399
M82 Osteoporosis in diseases classified elsewhere	0.600	0.400
M80.8 Other osteoporosis with pathological fracture	0.599	0.401
M80.4 Drug-induced osteoporosis with pathological fracture	0.599	0.401
M80.3 Postsurgical malabsorption osteoporosis with pathological fracture	0.599	0.401
M80.2 Osteoporosis of disuse with pathological fracture	0.599	0.401
Y59 Other and unspecified vaccines and biological substances	0.599	0.401
Y58 Bacterial vaccines	0.599	0.401
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system	0.599	0.401
Y50 Central nervous system stimulants, not elsewhere classified	0.599	0.401
V98-V99 Other and unspecified transport accidents	0.598	0.401
M85.9 Disorder of bone density and structure, unspecified	0.598	0.402
Y85.0 Sequelae of motor-vehicle accident	0.598	0.402
Q35-Q37 Cleft lip and cleft palate	0.597	0.403
Q30-Q34 Congenital malformations of the respiratory system	0.597	0.403
D03.2 Melanoma in situ of ear and external auricular canal	0.597	0.403
Y42.1 Thyroid hormones and substitutes	0.597	0.403
Q39 Congenital malformations of oesophagus	0.597	0.403
M22.9 Disorder of patella, unspecified	0.596	0.404
Y85.9 Sequelae of other and unspecified transport accidents	0.596	0.404
Q38.7 Pharyngeal pouch	0.595	0.405
C72.0 Spinal cord	0.595	0.405
M65-M68 Disorders of synovium and tendon	0.594	0.406
C75 Malignant neoplasm of other endocrine glands and related structures	0.593	0.406
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands	0.593	0.407
Y52.8 Antivaricose drugs, including sclerosing agents	0.591	0.409
Y52.7 Peripheral vasodilators	0.591	0.409
Y52.0 Cardiac-stimulant glycosides and drugs of similar action	0.591	0.409
C13.9 Hypopharynx, unspecified	0.590	0.410
H35.7 Separation of retinal layers	0.590	0.410
Y41 Other systemic anti-infectives and antiparasitics	0.588	0.412
M80.5 Idiopathic osteoporosis with pathological fracture	0.585	0.415
M93 Other osteochondropathies	0.585	0.415
L59.8 Other specified disorders of skin and subcutaneous tissue related to radiation	0.584	0.416
L59.0 Erythema ab igne [dermatitis ab igne]	0.584	0.416
M48.54 Collapsed vertebra, not elsewhere classified (Thoracic region)	0.584	0.416
L52 Erythema nodosum	0.584	0.416
X60-X84 Intentional self-harm	0.584	0.416
Q50-Q56 Congenital malformations of genital organs	0.583	0.417
Y53 Agents primarily affecting the gastro-intestinal system	0.582	0.418
W20-W49 Exposure to inanimate mechanical forces	0.580	0.420
M62 Other disorders of muscle	0.580	0.420
C48.0 Retroperitoneum	0.579	0.421
Q43.0 Meckel's diverticulum	0.579	0.421
C74 Malignant neoplasm of adrenal gland	0.579	0.421
H46-H48 Disorders of optic nerve and visual pathways	0.579	0.421
H35.4 Peripheral retinal degeneration	0.578	0.422
C42 hematopoietic and reticuloendothelial systems (ICD-O-3 specific)	0.576	0.424
C40 Malignant neoplasm of bone and articular cartilage of limbs	0.576	0.424
M23.46 Loose body in knee-O/unsp lat men	0.575	0.425
M40.24 Other and unspecified kyphosis (Thoracic region)	0.573	0.427
M84.42 Pathological fracture, not elsewhere classified (Upper arm)	0.573	0.427
Y57 Other and unspecified drugs and medicaments	0.573	0.427
V80-V89 Other land transport accidents	0.573	0.427
M43.6 Torticollis	0.573	0.427
L12 Pemphigoid	0.572	0.427
M00 Pyogenic arthritis	0.572	0.428
M20.2 Hallux rigidus	0.572	0.428
M41 Scoliosis	0.571	0.429
W50-W64 Exposure to animate mechanical forces	0.571	0.429
H04.5 Stenosis and insufficiency of lachrymal passages	0.570	0.430
L70.0 Acne vulgaris	0.569	0.430
M23.09 Cystic meniscus (Unspecified ligament or Unspecified meniscus)	0.569	0.431
D43.9 Central nervous system, unspecified	0.568	0.432
D43.7 Other parts of central nervous system	0.568	0.432
D43.4 Spinal cord	0.568	0.432
D43.3 Cranial nerves	0.568	0.432
D43.1 Brain, infratentorial	0.568	0.432
L50.8 Other urticaria	0.567	0.433
Q60-Q64 Congenital malformations of the urinary system	0.567	0.433
C25.3 Pancreatic duct	0.567	0.433
Y42.9 Other and unspecified hormone antagonists	0.567	0.433
Y42.4 Oral contraceptives	0.567	0.433
Y42.2 Antithyroid drugs	0.567	0.433
M23.47 Loose body in knee-Capsular lig	0.566	0.433
M23.45 Loose body in knee-Pst hrn lat men	0.566	0.433
M23.44 Loose body in knee-Lat lig/ant men	0.566	0.433
M23.42 Loose body in knee-Pst lig/hrn men	0.566	0.433
M23.41 Loose body in knee-Ant lig/hrn men	0.566	0.433
M23.40 Loose body in knee-Mult sites	0.566	0.433
M84.12 Nonunion of fracture [pseudarthrosis] (Upper arm)	0.566	0.434
C05.9 Palate, unspecified	0.566	0.434
M23.57 Chronic instability of knee (Capsular ligament)	0.566	0.434
M23.56 Chronic instability of knee (Other and unspecified lateral meniscus)	0.566	0.434
M23.55 Chronic instability of knee (Posterior horn of lateral meniscus)	0.566	0.434
M23.54 Chronic instability of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.566	0.434
M23.53 Chronic instability of knee (Medial collateral ligament or Other and unspecified medial meniscus)	0.566	0.434
M23.52 Chronic instability of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.566	0.434
M23.50 Chronic instability of knee (Multiple sites)	0.566	0.434
M23.99 Internal derangement of knee, unspecified (Unspecified ligament or Unspecified meniscus)	0.565	0.435
L80 Vitiligo	0.565	0.435
M60 Myositis	0.565	0.435
Q45 Other congenital malformations of digestive system	0.564	0.436
Q42 Congenital absence, atresia and stenosis of large intestine	0.564	0.436
Q41 Congenital absence, atresia and stenosis of small intestine	0.564	0.436
C48.1 Specified parts of peritoneum	0.564	0.436
Y46 Antiepileptics and anti-Parkinsonism drugs	0.563	0.437
L51.1 Bullous erythema multiforme	0.562	0.438
H34.1 Central retinal artery occlusion	0.562	0.438
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use	0.561	0.439
D00 Carcinoma in situ of oral cavity, oesophagus and stomach	0.560	0.439
Y45.2 Propionic acid derivatives	0.560	0.440
M91 Juvenile osteochondrosis of hip and pelvis	0.559	0.441
Y87 Sequelae of intentional self-harm, assault and events of undetermined intent	0.559	0.441
L51.9 Erythema multiforme, unspecified	0.559	0.441
L89.2 Stage III decubitus ulcer	0.558	0.442
M81 Osteoporosis without pathological fracture	0.558	0.442
L50.6 Contact urticaria	0.558	0.442
L50.5 Cholinergic urticaria	0.558	0.442
L50.4 Vibratory urticaria	0.558	0.442
L50.3 Dermatographic urticaria	0.558	0.442
L50.2 Urticaria due to cold and heat	0.558	0.442
L50.1 Idiopathic urticaria	0.558	0.442
Y48.4 Anaesthetic, unspecified	0.558	0.442
Y48.2 Other and unspecified general anaesthetics	0.557	0.443
D48.1 Connective and other soft tissue	0.556	0.444
M85.89 Other specified disorders of bone density and structure (Site unspecified)	0.556	0.444
H35.3 Degeneration of macula and posterior pole	0.556	0.444
C25.7 Other parts of pancreas	0.555	0.445
D47.4 Osteomyelofibrosis	0.555	0.445
H32 Chorioretinal disorders in diseases classified elsewhere	0.555	0.445
H30 Chorioretinal inflammation	0.555	0.445
M85.6 Other cyst of bone	0.554	0.446
D03.9 Melanoma in situ, unspecified	0.554	0.446
D03.8 Melanoma in situ of other sites	0.554	0.446
D03.1 Melanoma in situ of eyelid, including canthus	0.554	0.446
D03.0 Melanoma in situ of lip	0.554	0.446
Y40 Systemic antibiotics	0.552	0.448
M85.5 Aneurysmal bone cyst	0.552	0.448
M85.4 Solitary bone cyst	0.552	0.448
M85.3 Osteitis condensans	0.552	0.448
M85.2 Hyperostosis of skull	0.552	0.448
M85.1 Skeletal fluorosis	0.552	0.448
C25.1 Body of pancreas	0.551	0.449
M86 Osteomyelitis	0.550	0.450
H34.9 Retinal vascular occlusion, unspecified	0.550	0.450
H34.0 Transient retinal artery occlusion	0.550	0.450
M80.10 Postoophorectomy osteoporosis with pathological fracture (Multiple sites)	0.549	0.450
M48.56 Collapsed vertebra, not elsewhere classified (Lumbar region)	0.549	0.450
X47 Accidental poisoning by and exposure to other gases and vapours	0.549	0.451
M84.26 Delayed union of fracture (Lower leg)	0.548	0.452
H15-H22 Disorders of sclera, cornea, iris and ciliary body	0.548	0.452
M20.3 Other deformity of hallux (acquired)	0.548	0.452
C41.0 Bones of skull and face	0.545	0.455
L93.0 Discoid lupus erythematosus	0.545	0.455
M48.50 Collapsed vertebra, not elsewhere classified (Multiple sites in spine)	0.544	0.456
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs	0.544	0.456
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism	0.543	0.456
C72.9 Central nervous system, unspecified	0.543	0.457
C72.8 Overlapping lesion of brain and other parts of central nervous system	0.543	0.457
C72.5 Other and unspecified cranial nerves	0.543	0.457
C72.4 Acoustic nerve	0.543	0.457
C72.3 Optic nerve	0.543	0.457
C72.2 Olfactory nerve	0.543	0.457
C72.1 Cauda equina	0.543	0.457
M87.2 Osteonecrosis due to previous trauma	0.542	0.458
Y52.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.541	0.459
C69 Malignant neoplasm of eye and adnexa	0.540	0.460
H53.6 Night blindness	0.540	0.460
H53.5 Colour vision deficiencies	0.540	0.460
H53.3 Other disorders of binocular vision	0.540	0.460
C14.8 Overlapping lesion of lip, oral cavity and pharynx	0.539	0.460
C14.2 Waldeyer's ring	0.539	0.460
M63 Disorders of muscle in diseases classified elsewhere	0.539	0.461
M61 Calcification and ossification of muscle	0.539	0.461
H53.4 Visual field defects	0.539	0.461

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations