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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs6456834
log Bayes Factor = 126.157
Chromosome 6   position 28,700,352  (GRCh37) Explore rs6456834 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
E05.9 Thyrotoxicosis, unspecified
1.000 0.000 0.000
E10.9 Without complications
1.000 0.000 0.000
K90.0 Coeliac disease
1.000 0.000 0.000
E05 Thyrotoxicosis [hyperthyroidism]
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
1.000 0.000 0.000
E10-E14 Diabetes mellitus
1.000 0.000 0.000
E00-E07 Disorders of thyroid gland
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
E03 Other hypothyroidism
1.000 0.000 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
1.000 0.000 0.000
E16 Other disorders of pancreatic internal secretion
1.000 0.000 0.000
E05.0 Thyrotoxicosis with diffuse goitre
1.000 0.000 0.000
E16.2 Hypoglycaemia, unspecified
1.000 0.000 0.000
R31 Unspecified haematuria
0.000 0.001 0.999
E20-E35 Disorders of other endocrine glands
0.999 0.001 0.000
E27 Other disorders of adrenal gland
0.998 0.002 0.000
E27.1 Primary adrenocortical insufficiency
0.995 0.005 0.000
E10.3 With ophthalmic complications
0.994 0.006 0.000
E14 Unspecified diabetes mellitus
0.980 0.020 0.000
K90 Intestinal malabsorption
0.978 0.022 0.000
E10.2 With renal complications
0.976 0.024 0.000
E14.3 With ophthalmic complications
0.962 0.038 0.000
E10.1 With ketoacidosis
0.960 0.040 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.947 0.053 0.000
C15-C26 Malignant neoplasms of digestive organs
0.945 0.055 0.000
D80-D89 Certain disorders involving the immune mechanism
0.944 0.056 0.000
D86 Sarcoidosis
0.943 0.057 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.942 0.058 0.000
Chapter II Neoplasms
0.940 0.060 0.000
D86.9 Sarcoidosis, unspecified
0.939 0.061 0.000
C25 Malignant neoplasm of pancreas
0.938 0.062 0.000
# Top node
0.936 0.064 0.000
C15 Malignant neoplasm of oesophagus
0.936 0.064 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.931 0.069 0.000
E83.1 Disorders of iron metabolism
0.000 0.073 0.927
K90-K93 Other diseases of the digestive system
0.918 0.082 0.000
C25.9 Pancreas, unspecified
0.915 0.085 0.000
Chapter XI Diseases of the digestive system
0.915 0.085 0.000
K70-K77 Diseases of liver
0.912 0.088 0.000
E13 Other specified diabetes mellitus
0.911 0.089 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.910 0.090 0.000
D60-D64 Aplastic and other anaemias
0.906 0.094 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.905 0.095 0.000
K75 Other inflammatory liver diseases
0.902 0.098 0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.902 0.098 0.000
C19 Malignant neoplasm of rectosigmoid junction
0.900 0.100 0.000
K75.4 Autoimmune hepatitis
0.900 0.100 0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.894 0.106 0.000
C16 Malignant neoplasm of stomach
0.893 0.107 0.000
K72 Hepatic failure, not elsewhere classified
0.886 0.114 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.884 0.116 0.000
R39.8 Other and unspecified symptoms and signs involving the urinary system
0.000 0.117 0.883
C15.9 Oesophagus, unspecified
0.868 0.132 0.000
E20 Hypoparathyroidism
0.864 0.136 0.000
R39 Other symptoms and signs involving the urinary system
0.000 0.140 0.860
D64 Other anaemias
0.856 0.144 0.000
C04 Malignant neoplasm of floor of mouth
0.854 0.146 0.000
C15.4 Middle third of oesophagus
0.854 0.146 0.000
E24 Cushing's syndrome
0.853 0.147 0.000
R30-R39 Symptoms and signs involving the urinary system
0.000 0.147 0.852
E10.4 With neurological complications
0.849 0.151 0.000
E13.9 Without complications
0.848 0.152 0.000
C85.1 B-cell lymphoma, unspecified
0.846 0.154 0.000
D61 Other aplastic anaemias
0.843 0.157 0.000
Q44 Congenital malformations of gallbladder, bile ducts and liver
0.842 0.158 0.000
K73 Chronic hepatitis, not elsewhere classified
0.837 0.163 0.000
D64.9 Anaemia, unspecified
0.833 0.167 0.000
K72.9 Hepatic failure, unspecified
0.830 0.170 0.000
C43-C44 Melanoma and other malignant neoplasms of skin
0.827 0.173 0.000
C25.3 Pancreatic duct
0.820 0.180 0.000
D86.8 Sarcoidosis of other and combined sites
0.818 0.182 0.000
K35-K38 Diseases of appendix
0.817 0.183 0.000
C16.5 Lesser curvature of stomach, unspecified
0.817 0.183 0.000
E10.0 With coma
0.808 0.192 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.808 0.192 0.000
D00-D09 In situ neoplasms
0.807 0.193 0.000
C43 Malignant melanoma of skin
0.804 0.196 0.000
K35.9 Acute appendicitis, unspecified
0.800 0.200 0.000
K35 Acute appendicitis
0.799 0.201 0.000
D80 Immunodeficiency with predominantly antibody defects
0.795 0.205 0.000
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.794 0.206 0.000
E29 Testicular dysfunction
0.794 0.206 0.000
C02 Malignant neoplasm of other and unspecified parts of tongue
0.790 0.209 0.000
E10.7 With multiple complications
0.788 0.211 0.000
C01 Malignant neoplasm of base of tongue
0.787 0.213 0.000
Q43 Other congenital malformations of intestine
0.787 0.213 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.783 0.217 0.000
C84 Peripheral and cutaneous T-cell lymphomas
0.783 0.217 0.000
D83 Common variable immunodeficiency
0.778 0.222 0.000
D84 Other immunodeficiencies
0.774 0.226 0.000
Q50-Q56 Congenital malformations of genital organs
0.774 0.226 0.000
D61.9 Aplastic anaemia, unspecified
0.770 0.230 0.000
Q44.6 Cystic disease of liver
0.769 0.231 0.000
C15.0 Cervical part of oesophagus
0.768 0.231 0.000
E14.9 Without complications
0.768 0.232 0.000
E20.9 Hypoparathyroidism, unspecified
0.768 0.232 0.000
E05.8 Other thyrotoxicosis
0.767 0.233 0.000
D86.0 Sarcoidosis of lung
0.767 0.233 0.000
C03 Malignant neoplasm of gum
0.767 0.233 0.000
E16.1 Other hypoglycaemia
0.767 0.233 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.765 0.235 0.000
E40-E46 Malnutrition
0.765 0.235 0.000
E34 Other endocrine disorders
0.765 0.235 0.000
K72.0 Acute and subacute hepatic failure
0.763 0.237 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.762 0.238 0.000
C25.2 Tail of pancreas
0.754 0.246 0.000
C15.3 Upper third of oesophagus
0.752 0.248 0.000
C13 Malignant neoplasm of hypopharynx
0.748 0.252 0.000
C25.1 Body of pancreas
0.744 0.256 0.000
C04.0 Anterior floor of mouth
0.743 0.257 0.000
E27.2 Addisonian crisis
0.743 0.257 0.000
Q44.5 Other congenital malformations of bile ducts
0.742 0.258 0.000
K73.2 Chronic active hepatitis, not elsewhere classified
0.740 0.260 0.000
E24.2 Drug-induced Cushing's syndrome
0.738 0.262 0.000
D06 Carcinoma in situ of cervix uteri
0.737 0.263 0.000
C04.9 Floor of mouth, unspecified
0.735 0.265 0.000
C15.1 Thoracic part of oesophagus
0.734 0.266 0.000
C07 Malignant neoplasm of parotid gland
0.732 0.268 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.729 0.271 0.000
C43.3 Malignant melanoma of other and unspecified parts of face
0.727 0.273 0.000
E14.2 Withrenal complications
0.725 0.275 0.000
C06 Malignant neoplasm of other and unspecified parts of mouth
0.721 0.279 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.719 0.281 0.001
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.719 0.281 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.717 0.283 0.000
E14.4 With neurological complications
0.717 0.283 0.000
E05.5 Thyroid crisis or storm
0.717 0.283 0.000
E05.4 Thyrotoxicosis factitia
0.717 0.283 0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.717 0.283 0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.717 0.283 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.717 0.283 0.000
E00 Congenital iodine-deficiency syndrome
0.717 0.283 0.000
E12 Malnutrition-related diabetes mellitus
0.717 0.283 0.000
C09 Malignant neoplasm of tonsil
0.717 0.283 0.000
E03.5 Myxoedema coma
0.717 0.283 0.000
E03.4 Atrophy of thyroid (acquired)
0.717 0.283 0.000
E03.3 Postinfectious hypothyroidism
0.717 0.283 0.000
E03.1 Congenital hypothyroidism without goitre
0.717 0.283 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.717 0.283 0.000
E15 Nondiabetic hypoglycaemic coma
0.717 0.283 0.000
E14.8 With unspecified complications
0.717 0.283 0.000
E16.9 Disorder of pancreatic internal secretion, unspecified
0.717 0.283 0.000
E16.8 Other specified disorders of pancreatic internal secretion
0.717 0.283 0.000
E16.4 Abnormal secretion of gastrin
0.717 0.283 0.000
E16.3 Increased secretion of glucagon
0.717 0.283 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.716 0.284 0.000
E32 Diseases of thymus
0.716 0.284 0.000
E31 Polyglandular dysfunction
0.716 0.284 0.000
E30 Disorders of puberty, not elsewhere classified
0.716 0.284 0.000
E25 Adrenogenital disorders
0.716 0.284 0.000
E27.5 Adrenomedullary hyperfunction
0.715 0.285 0.000
E27.0 Other adrenocortical overactivity
0.715 0.285 0.000
C16.8 Overlapping lesion of stomach
0.715 0.285 0.000
K90.8 Other intestinal malabsorption
0.715 0.285 0.000
C85.7 Other specified types of non-Hodgkin's lymphoma
0.714 0.285 0.000
K72.1 Chronic hepatic failure
0.714 0.286 0.000
K75.8 Other specified inflammatory liver diseases
0.712 0.288 0.000
C43.6 Malignant melanoma of upper limb, including shoulder
0.711 0.289 0.000
L50-L54 Urticaria and erythema
0.710 0.290 0.000
C05 Malignant neoplasm of palate
0.708 0.292 0.000
C16.0 Cardia
0.707 0.293 0.000
E14.5 With peripheral circulatory complications
0.706 0.294 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.704 0.295 0.000
E14.7 With multiple complications
0.703 0.297 0.000
E14.0 With coma
0.703 0.297 0.000
Q40 Other congenital malformations of upper alimentary tract
0.702 0.298 0.000
E50-E64 Other nutritional deficiencies
0.702 0.298 0.000
K90.3 Pancreatic steatorrhoea
0.701 0.299 0.000
K90.2 Blind loop syndrome, not elsewhere classified
0.701 0.299 0.000
K90.1 Tropical sprue
0.701 0.299 0.000
K73.9 Chronic hepatitis, unspecified
0.701 0.299 0.000
K90.9 Intestinal malabsorption, unspecified
0.700 0.300 0.000
C81 Hodgkin's disease
0.698 0.302 0.000
E24.0 Pituitary-dependent Cushing's disease
0.697 0.303 0.000
Q45 Other congenital malformations of digestive system
0.696 0.304 0.000
Q00-Q07 Congenital malformations of the nervous system
0.696 0.304 0.000
E23 Hypofunction and other disorders of pituitary gland
0.695 0.304 0.000
Q43.8 Other specified congenital malformations of intestine
0.692 0.308 0.000
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.692 0.308 0.000
C02.9 Tongue, unspecified
0.689 0.311 0.000
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.688 0.312 0.000
D06.9 Cervix, unspecified
0.688 0.312 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.688 0.312 0.000
D04 Carcinoma in situ of skin
0.688 0.312 0.000
C85.2 Mediastinal (thymic) large B-cell lymphoma
0.685 0.315 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.685 0.315 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.684 0.316 0.000
Q43.3 Congenital malformations of intestinal fixation
0.684 0.316 0.000
C25.0 Head of pancreas
0.682 0.318 0.000
C11 Malignant neoplasm of nasopharynx
0.682 0.318 0.000
D69 Purpura and other haemorrhagic conditions
0.680 0.320 0.000
E10.6 With other specified complications
0.679 0.321 0.000
D82 Immunodeficiency associated with other major defects
0.677 0.323 0.000
D81 Combined immunodeficiencies
0.677 0.323 0.000
C17 Malignant neoplasm of small intestine
0.677 0.323 0.000
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.676 0.324 0.000
E03.8 Other specified hypothyroidism
0.674 0.326 0.000
E14.6 With other specified complications
0.673 0.327 0.000
C25.8 Overlapping lesion of pancreas
0.673 0.327 0.000
C25.4 Endocrine pancreas
0.673 0.327 0.000
D61.0 Constitutional aplastic anaemia
0.671 0.328 0.000
C83 Diffuse non-Hodgkin's lymphoma
0.671 0.329 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.671 0.329 0.000
C15.8 Overlapping lesion of oesophagus
0.671 0.329 0.000
C15.2 Abdominal part of oesophagus
0.671 0.329 0.000
C16.2 Body of stomach
0.670 0.330 0.000
E14.1 With ketoacidosis
0.669 0.331 0.000
C08 Malignant neoplasm of other and unspecified major salivary glands
0.667 0.332 0.000
C00 Malignant neoplasm of lip
0.667 0.332 0.000
C25.7 Other parts of pancreas
0.666 0.334 0.000
D86.3 Sarcoidosis of skin
0.666 0.334 0.000
C84.0 Mycosis fungoides
0.662 0.338 0.000
L53 Other erythematous conditions
0.661 0.339 0.000
D55-D59 Haemolytic anaemias
0.661 0.339 0.000
C95 Leukaemia of unspecified cell type
0.661 0.339 0.000
C88 Malignant immunoproliferative diseases
0.661 0.339 0.000
C10 Malignant neoplasm of oropharynx
0.661 0.339 0.000
E28 Ovarian dysfunction
0.661 0.339 0.000
D83.9 Common variable immunodeficiency, unspecified
0.659 0.341 0.000
C15.5 Lower third of oesophagus
0.658 0.342 0.000
K93 Disorders of other digestive organs in diseases classified elsewhere
0.658 0.342 0.000
C16.3 Pyloric antrum
0.658 0.342 0.000
K77 Liver disorders in diseases classified elsewhere
0.654 0.346 0.000
K71 Toxic liver disease
0.654 0.346 0.000
E13.8 With unspecified complications
0.653 0.346 0.000
E13.7 With multiple complications
0.653 0.346 0.000
E13.6 With other specified complications
0.653 0.346 0.000
E13.5 With peripheral circulatory complications
0.653 0.346 0.000
E13.4 With neurological complications
0.653 0.346 0.000
E13.3 With ophthalmic complications
0.653 0.346 0.000
E13.2 With renal complications
0.653 0.346 0.000
E13.1 With ketoacidosis
0.653 0.346 0.000
E13.0 With coma
0.653 0.346 0.000
E22 Hyperfunction of pituitary gland
0.652 0.347 0.000
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.652 0.347 0.000
C94 Other leukaemias of specified cell type
0.652 0.347 0.000
C86 Other specified types of T/NK-cell lymphoma
0.652 0.347 0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.649 0.350 0.000
E10.5 With peripheral circulatory complications
0.649 0.350 0.000
C03.1 Lower gum
0.649 0.351 0.000
Q35-Q37 Cleft lip and cleft palate
0.649 0.351 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.649 0.351 0.000
C84.5 Other and unspecified T-cell lymphomas
0.648 0.352 0.000
L10-L14 Bullous disorders
0.648 0.352 0.000
E29.1 Testicular hypofunction
0.648 0.352 0.000
C43.7 Malignant melanoma of lower limb, including hip
0.647 0.353 0.000
K75.3 Granulomatous hepatitis, not elsewhere classified
0.647 0.353 0.000
K75.2 Nonspecific reactive hepatitis
0.647 0.353 0.000
K75.1 Phlebitis of portal vein
0.647 0.353 0.000
L50 Urticaria
0.647 0.353 0.000
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.645 0.355 0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.644 0.356 0.000
D09 Carcinoma in situ of other and unspecified sites
0.642 0.357 0.000
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.642 0.358 0.000
C85.0 Lymphosarcoma
0.641 0.359 0.000
K35.1 Acute appendicitis with peritoneal abscess
0.641 0.359 0.000
C16.4 Pylorus
0.640 0.360 0.000
C16.1 Fundus of stomach
0.640 0.360 0.000
D61.1 Drug-induced aplastic anaemia
0.639 0.361 0.000
C16.6 Greater curvature of stomach, unspecified
0.638 0.362 0.000
Q42 Congenital absence, atresia and stenosis of large intestine
0.634 0.366 0.000
Q41 Congenital absence, atresia and stenosis of small intestine
0.634 0.366 0.000
C23 Malignant neoplasm of gallbladder
0.632 0.368 0.000
L52 Erythema nodosum
0.631 0.369 0.000
C38 Malignant neoplasm of heart, mediastinum and pleura
0.628 0.372 0.000
C43.9 Malignant melanoma of skin, unspecified
0.628 0.372 0.000
D84.1 Defects in the complement system
0.628 0.372 0.000
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.626 0.374 0.000
E34.9 Endocrine disorder, unspecified
0.620 0.380 0.000
E20.8 Other hypoparathyroidism
0.620 0.380 0.000
E20.1 Pseudohypoparathyroidism
0.620 0.380 0.000
E20.0 Idiopathic hypoparathyroidism
0.620 0.380 0.000
L53.9 Erythematous condition, unspecified
0.619 0.381 0.000
C93 Monocytic leukaemia
0.618 0.381 0.000
R39.2 Extrarenal uraemia
0.000 0.383 0.617
C43.4 Malignant melanoma of scalp and neck
0.616 0.384 0.000
D86.1 Sarcoidosis of lymph nodes
0.614 0.386 0.000
D64.4 Congenital dyserythropoietic anaemia
0.613 0.386 0.000
D64.3 Other sideroblastic anaemias
0.613 0.386 0.000
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.613 0.386 0.000
D64.1 Secondary sideroblastic anaemia due to disease
0.613 0.386 0.000
D64.0 Hereditary sideroblastic anaemia
0.613 0.386 0.000
C04.8 Overlapping lesion of floor of mouth
0.613 0.387 0.000
C04.1 Lateral floor of mouth
0.613 0.387 0.000
Q51 Congenital malformations of uterus and cervix
0.612 0.388 0.000
E24.8 Other Cushing's syndrome
0.611 0.389 0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.611 0.389 0.000
E24.3 Ectopic ACTH syndrome
0.611 0.389 0.000
E24.1 Nelson's syndrome
0.611 0.389 0.000
L40-L45 Papulosquamous disorders
0.610 0.389 0.000
E10.8 With unspecified complications
0.610 0.390 0.000
D04.2 Skin of ear and external auricular canal
0.610 0.390 0.000
Q39 Congenital malformations of oesophagus
0.608 0.392 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.608 0.392 0.000
C83.3 Large cell (diffuse)
0.607 0.393 0.000
D61.8 Other specified aplastic anaemias
0.604 0.395 0.000
D61.3 Idiopathic aplastic anaemia
0.604 0.395 0.000
D61.2 Aplastic anaemia due to other external agents
0.604 0.395 0.000
K73.8 Other chronic hepatitis, not elsewhere classified
0.604 0.395 0.000
E27.9 Disorder of adrenal gland, unspecified
0.604 0.396 0.000
D00 Carcinoma in situ of oral cavity, oesophagus and stomach
0.604 0.396 0.000
Q44.7 Other congenital malformations of liver
0.603 0.396 0.000
Q44.4 Choledochal cyst
0.603 0.396 0.000
Q44.3 Congenital stenosis and stricture of bile ducts
0.603 0.396 0.000
Q44.2 Atresia of bile ducts
0.603 0.396 0.000
Q44.1 Other congenital malformations of gallbladder
0.603 0.396 0.000
Q44.0 Agenesis, aplasia and hypoplasia of gallbladder
0.603 0.396 0.000
D02 Carcinoma in situ of middle ear and respiratory system
0.603 0.397 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.603 0.397 0.000
Q50 Congenital malformations of ovaries, Fallopian tubes and broad ligaments
0.602 0.398 0.000
K73.1 Chronic lobular hepatitis, not elsewhere classified
0.600 0.400 0.000
K73.0 Chronic persistent hepatitis, not elsewhere classified
0.600 0.400 0.000
C43.5 Malignant melanoma of trunk
0.599 0.401 0.000
C16.9 Stomach, unspecified
0.599 0.401 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.599 0.401 0.000
D62 Acute posthaemorrhagic anaemia
0.599 0.401 0.000
C30 Malignant neoplasm of nasal cavity and middle ear
0.599 0.401 0.000
C82.2 Large cell, follicular
0.598 0.402 0.000
E46 Unspecified protein-energy malnutrition
0.597 0.403 0.000
C90 Multiple myeloma and malignant plasma cell neoplasms
0.596 0.404 0.000
D69.3 Idiopathic thrombocytopenic purpura
0.592 0.408 0.000
D84.9 Immunodeficiency, unspecified
0.591 0.409 0.000
D69.4 Other primary thrombocytopenia
0.589 0.411 0.000
C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx
0.589 0.411 0.000
L50.9 Urticaria, unspecified
0.589 0.411 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.588 0.412 0.000
M65-M68 Disorders of synovium and tendon
0.584 0.416 0.000
Q79 Congenital malformations of musculoskeletal system, not elsewhere classified
0.584 0.416 0.000
C13.0 Postcricoid region
0.583 0.417 0.000
C12 Malignant neoplasm of pyriform sinus
0.582 0.418 0.000
C13.9 Hypopharynx, unspecified
0.580 0.420 0.000
Q55 Other congenital malformations of male genital organs
0.579 0.420 0.000
C43.8 Overlapping malignant melanoma of skin
0.577 0.423 0.000
C43.1 Malignant melanoma of eyelid, including canthus
0.577 0.423 0.000
C43.0 Malignant melanoma of lip
0.577 0.423 0.000
C05.9 Palate, unspecified
0.574 0.426 0.000
M67 Other disorders of synovium and tendon
0.574 0.426 0.000
E26 Hyperaldosteronism
0.573 0.426 0.000
M72.04 Palmar fascial fibromatosis [Dupuytren]-Hand
0.573 0.427 0.000
Q40.2 Other specified congenital malformations of stomach
0.572 0.428 0.000
Q53 Undescended testicle
0.571 0.429 0.000
D80.8 Other immunodeficiencies with predominantly antibody defects
0.570 0.430 0.000
D80.7 Transient hypogammaglobulinaemia of infancy
0.570 0.430 0.000
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.570 0.430 0.000
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.570 0.430 0.000
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.570 0.430 0.000
D80.0 Hereditary hypogammaglobulinaemia
0.570 0.430 0.000
C41 Malignant neoplasm of bone and articular cartilage of other and unspecified sites
0.569 0.430 0.000
E29.9 Testicular dysfunction, unspecified
0.569 0.430 0.000
E29.8 Other testicular dysfunction
0.569 0.430 0.000
E29.0 Testicular hyperfunction
0.569 0.430 0.000
C02.1 Border of tongue
0.569 0.431 0.000
C02.8 Overlapping lesion of tongue
0.567 0.433 0.000
C02.4 Lingual tonsil
0.567 0.433 0.000
C02.3 Anterior two-thirds of tongue, part unspecified
0.567 0.433 0.000
C02.2 Ventral surface of tongue
0.567 0.433 0.000
C02.0 Dorsal surface of tongue
0.567 0.433 0.000
Q54 Hypospadias
0.566 0.434 0.000
L13 Other bullous disorders
0.565 0.435 0.000
Q52 Other congenital malformations of female genitalia
0.565 0.435 0.000
L43 Lichen planus
0.564 0.435 0.000
M72.0 Palmar fascial fibromatosis [Dupuytren]
0.564 0.436 0.000
Q43.7 Persistent cloaca
0.564 0.436 0.000
Q43.6 Congenital fistula of rectum and anus
0.564 0.436 0.000
Q43.5 Ectopic anus
0.564 0.436 0.000
Q43.4 Duplication of intestine
0.564 0.436 0.000
Q43.2 Other congenital functional disorders of colon
0.564 0.436 0.000
Q43.1 Hirschsprung's disease
0.564 0.436 0.000
C81.2 Mixed cellularity
0.564 0.436 0.000
C09.9 Tonsil, unspecified
0.564 0.436 0.000
Q45.8 Other specified congenital malformations of digestive system
0.562 0.438 0.000
C84.9 Mature T/NK-cell lymphoma, unspecified
0.561 0.438 0.000
C84.8 Cutaneous T-cell lymphoma, unspecified
0.561 0.438 0.000
C84.7 Anaplastic large cell lymphoma, ALK-negative
0.561 0.438 0.000
C84.6 Anaplastic large cell lymphoma, ALK-positive
0.561 0.438 0.000
C84.3 Lymphoepithelioid lymphoma
0.561 0.438 0.000
C84.2 T-zone lymphoma
0.561 0.438 0.000
C84.1 Sezary's diease
0.561 0.438 0.000
Q77 Osteochondrodysplasia with defects of growth of tubular bones and spine
0.561 0.439 0.000
M67.8 Other specified disorders of synovium and tendon
0.561 0.439 0.000
Q98 Other sex chromosome abnormalities, male phenotype, not elsewhere classified
0.561 0.439 0.000
M70-M79 Other soft tissue disorders
0.559 0.441 0.000
M72 Fibroblastic disorders
0.559 0.441 0.000
C26 Malignant neoplasm of other and ill-defined digestive organs
0.558 0.442 0.000
Q60-Q64 Congenital malformations of the urinary system
0.558 0.442 0.000
D83.8 Other common variable immunodeficiencies
0.558 0.442 0.000
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.558 0.442 0.000
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.558 0.442 0.000
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.558 0.442 0.000
Q74 Other congenital malformations of limb(s)
0.557 0.442 0.000
D07 Carcinoma in situ of other and unspecified genital organs
0.556 0.444 0.000
Q04 Other congenital malformations of brain
0.556 0.444 0.000
D84.8 Other specified immunodeficiencies
0.555 0.445 0.000
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.555 0.445 0.000
K35.2 Acute appendicitis with generalized peritonitis
0.555 0.445 0.000
Q56 Indeterminate sex and pseudohermaphroditism
0.555 0.445 0.000
Q76 Congenital malformations of spine and bony thorax
0.554 0.446 0.000
K75.9 Inflammatory liver disease, unspecified
0.553 0.447 0.000
E06 Thyroiditis
0.551 0.449 0.000
D69.9 Haemorrhagic condition, unspecified
0.550 0.450 0.000
C03.9 Gum, unspecified
0.550 0.450 0.000
C03.0 Upper gum
0.550 0.450 0.000
E44 Protein-energy malnutrition of moderate and mild degree
0.549 0.451 0.000
E45 Retarded development following protein-energy malnutrition
0.549 0.451 0.000
E43 Unspecified severe protein-energy malnutrition
0.549 0.451 0.000
E42 Marasmic kwashiorkor
0.549 0.451 0.000
E41 Nutritional marasmus
0.549 0.451 0.000
E40 Kwashiorkor
0.549 0.451 0.000
E34.5 Androgen resistance syndrome
0.548 0.452 0.000
E34.4 Constitutional tall stature
0.548 0.452 0.000
E34.3 Short stature, not elsewhere classified
0.548 0.452 0.000
E34.2 Ectopic hormone secretion, not elsewhere classified
0.548 0.452 0.000
E34.1 Other hypersecretion of intestinal hormones
0.548 0.452 0.000
C39 Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs
0.547 0.453 0.000
C31 Malignant neoplasm of accessory sinuses
0.547 0.453 0.000
C37 Malignant neoplasm of thymus
0.547 0.453 0.000
C33 Malignant neoplasm of trachea
0.547 0.453 0.000
C06.2 Retromolar area
0.546 0.454 0.000
E22.1 Hyperprolactinaemia
0.545 0.455 0.000
C22.1 Intrahepatic bile duct carcinoma
0.545 0.455 0.000
C06.0 Cheek mucosa
0.545 0.455 0.000
E34.8 Other specified endocrine disorders
0.544 0.455 0.000
C69 Malignant neoplasm of eye and adnexa
0.544 0.456 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.541 0.458 0.000
D01 Carcinoma in situ of other and unspecified digestive organs
0.541 0.459 0.000
R39.0 Extravasation of urine
0.000 0.460 0.540
K36 Other appendicitis
0.540 0.460 0.000
L43.9 Lichen planus, unspecified
0.540 0.460 0.000
C88.4 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]
0.539 0.461 0.000
Q43.9 Congenital malformation of intestine, unspecified
0.537 0.463 0.000
C34 Malignant neoplasm of bronchus and lung
0.537 0.463 0.000
C13.8 Overlapping lesion of hypopharynx
0.537 0.463 0.000
C13.2 Posterior wall of hypopharynx
0.537 0.463 0.000
C13.1 Aryepiglottic fold, hypopharyngeal aspect
0.537 0.463 0.000
D04.3 Skin of other and unspecified parts of face
0.536 0.464 0.000
C81.0 Lymphocytic predominance
0.534 0.465 0.000
K35.3 Acute appendicitis with localized peritonitis
0.532 0.468 0.000
C40 Malignant neoplasm of bone and articular cartilage of limbs
0.532 0.468 0.000
C38.4 Pleura
0.532 0.468 0.000
L50.0 Allergic urticaria
0.529 0.471 0.000
D06.7 Other parts of cervix
0.529 0.471 0.000
D06.1 Exocervix
0.529 0.471 0.000
C17.0 Duodenum
0.529 0.471 0.000
L11 Other acantholytic disorders
0.528 0.471 0.000
D06.0 Endocervix
0.525 0.474 0.000
D09.0 Bladder
0.524 0.476 0.000
C42 hematopoietic and reticuloendothelial systems (ICD-O-3 specific)
0.522 0.477 0.000
D69.0 Allergic purpura
0.521 0.479 0.000
D89.9 Disorder involving the immune mechanism, unspecified
0.519 0.481 0.000
Q07 Other congenital malformations of nervous system
0.519 0.481 0.000
C70 Malignant neoplasm of meninges
0.518 0.481 0.000
D73 Diseases of spleen
0.519 0.481 0.000
E34.0 Carcinoid syndrome
0.518 0.482 0.000
C91 Lymphoid leukaemia
0.518 0.482 0.000
C06.9 Mouth, unspecified
0.517 0.483 0.000
C06.8 Overlapping lesion of other and unspecified parts of mouth
0.517 0.483 0.000
C06.1 Vestibule of mouth
0.517 0.483 0.000
Q65 Congenital deformities of hip
0.516 0.483 0.000
D66 Hereditary factor VIII deficiency
0.516 0.484 0.000
D04.9 Skin, unspecified
0.516 0.484 0.000
D67 Hereditary factor IX deficiency
0.515 0.485 0.000
D04.6 Skin of upper limb, including shoulder
0.515 0.485 0.000
E27.8 Other specified disorders of adrenal gland
0.515 0.485 0.000
E51 Thiamine deficiency
0.515 0.485 0.000
Q75 Other congenital malformations of skull and face bones
0.514 0.486 0.000
Q73 Reduction defects of unspecified limb
0.514 0.486 0.000
Q72 Reduction defects of lower limb
0.514 0.486 0.000
Q71 Reduction defects of upper limb
0.514 0.486 0.000
Q70 Syndactyly
0.514 0.486 0.000
Q69 Polydactyly
0.514 0.486 0.000
Q68 Other congenital musculoskeletal deformities
0.514 0.486 0.000
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.514 0.486 0.000
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.514 0.486 0.000
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.514 0.486 0.000
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.514 0.486 0.000
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.514 0.486 0.000
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.514 0.486 0.000
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.514 0.486 0.000
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.514 0.486 0.000
E12.9 Without complications
0.514 0.486 0.000
E12.8 With unspecified complications
0.514 0.486 0.000
E12.7 With multiple complications
0.514 0.486 0.000
E12.6 With other specified complications
0.514 0.486 0.000
E12.5 With peripheral circulatory complications
0.514 0.486 0.000
E12.4 With neurological complications
0.514 0.486 0.000
E12.3 With ophthalmic complications
0.514 0.486 0.000
E12.2 With renal complications
0.514 0.486 0.000
E12.1 With ketoacidosis
0.514 0.486 0.000
E12.0 With coma
0.514 0.486 0.000
C09.8 Overlapping lesion of tonsil
0.514 0.486 0.000
C09.1 Tonsillar pillar (anterior) (posterior)
0.514 0.486 0.000
C09.0 Tonsillar fossa
0.514 0.486 0.000
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.514 0.486 0.000
E25.9 Adrenogenital disorder, unspecified
0.513 0.486 0.000
E25.8 Other adrenogenital disorders
0.513 0.486 0.000
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.513 0.486 0.000
E30.9 Disorder of puberty, unspecified
0.513 0.486 0.000
E30.8 Other disorders of puberty
0.513 0.486 0.000
E30.1 Precocious puberty
0.513 0.486 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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