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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs67405884
log Bayes Factor = 19.8101
Chromosome 19   position 50,229,382  (GRCh37) Explore rs67405884 on Ensembl!
Variant rs67405884 is part of Cluster X0013

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter VI Diseases of the nervous system
1.000 0.000 0.000
Chapter XV Pregnancy, childbirth and the puerperium
1.000 0.000 0.000
Chapter XX External causes of morbidity and mortality
0.998 0.002 0.000
S00-S09 Injuries to the head
0.995 0.005 0.000
E10-E14 Diabetes mellitus
0.995 0.005 0.000
E70-E90 Metabolic disorders
0.995 0.005 0.000
M50-M54 Other dorsopathies
0.994 0.006 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.994 0.006 0.000
E11 Non-insulin-dependent diabetes mellitus
0.993 0.007 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.992 0.008 0.000
O60-O75 Complications of labour and delivery
0.991 0.009 0.000
M54 Dorsalgia
0.991 0.009 0.000
T92 Sequelae of injuries of upper limb
0.991 0.009 0.000
G40-G47 Episodic and paroxysmal disorders
0.988 0.012 0.000
O70 Perineal laceration during delivery
0.988 0.012 0.000
O70.1 Second degree perineal laceration during delivery
0.987 0.013 0.000
E11.3 With ophthalmic complications
0.982 0.018 0.000
M54.5 Low back pain
0.981 0.019 0.000
G40 Epilepsy
0.980 0.020 0.000
T66-T78 Other and unspecified effects of external causes
0.979 0.021 0.000
E00-E07 Disorders of thyroid gland
0.976 0.024 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.970 0.030 0.000
G30-G32 Other degenerative diseases of the nervous system
0.967 0.033 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.967 0.033 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.966 0.034 0.000
M86-M90 Other osteopathies
0.964 0.036 0.000
Chapter V Mental and behavioural disorders
0.961 0.039 0.000
M54.56 Low back pain (Lumbar region)
0.959 0.041 0.000
M70-M79 Other soft tissue disorders
0.956 0.044 0.000
S02 Fracture of skull and facial bones
0.956 0.044 0.000
G40.9 Epilepsy, unspecified
0.955 0.045 0.000
T78 Adverse effects, not elsewhere classified
0.952 0.048 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.948 0.052 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.947 0.053 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.946 0.054 0.000
Y42.5 Other oestrogens and progestogens
0.945 0.055 0.000
M45-M49 Spondylopathies
0.941 0.059 0.000
Chapter VII Diseases of the eye and adnexa
0.938 0.062 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.934 0.066 0.000
M65-M68 Disorders of synovium and tendon
0.931 0.069 0.000
E03 Other hypothyroidism
0.929 0.071 0.000
M79.6 Pain in limb
0.926 0.074 0.000
G45 Transient cerebral ischaemic attacks and related syndromes
0.926 0.074 0.000
E87.5 Hyperkalaemia
0.921 0.079 0.000
S00 Superficial injury of head
0.920 0.080 0.000
S10-S19 Injuries to the neck
0.920 0.080 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.917 0.083 0.000
H30-H36 Disorders of choroid and retina
0.917 0.083 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.915 0.085 0.000
G30 Alzheimer's disease
0.915 0.085 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.914 0.086 0.000
T78.2 Anaphylactic shock, unspecified
0.913 0.087 0.000
S20-S29 Injuries to the thorax
0.913 0.087 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.911 0.089 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.910 0.090 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.908 0.092 0.000
E16 Other disorders of pancreatic internal secretion
0.908 0.092 0.000
M48 Other spondylopathies
0.907 0.093 0.000
H36 Retinal disorders in diseases classified elsewhere
0.906 0.094 0.000
E11.2 With renal complications
0.905 0.095 0.000
O26 Maternal care for other conditions predominantly related to pregnancy
0.905 0.095 0.000
M54.1 Radiculopathy
0.904 0.096 0.000
G40.6 Grand mal seizures, unspecified (with or without petit mal)
0.902 0.098 0.000
W00-W19 Falls
0.900 0.100 0.000
H36.0 Diabetic retinopathy
0.898 0.102 0.000
E03.9 Hypothyroidism, unspecified
0.895 0.105 0.000
M79.62 Pain in limb (Upper arm)
0.892 0.108 0.000
F60-F69 Disorders of adult personality and behaviour
0.886 0.114 0.000
E87.6 Hypokalaemia
0.884 0.116 0.000
O26.8 Other specified pregnancy-related conditions
0.883 0.117 0.000
O69 Labour and delivery complicated by umbilical cord complications
0.882 0.118 0.000
T92.1 Sequelae of fracture of arm
0.880 0.120 0.000
M54.50 Low back pain (Multiple sites in spine)
0.879 0.121 0.000
S09 Other and unspecified injuries of head
0.878 0.122 0.000
Y52 Agents primarily affecting the cardiovascular system
0.878 0.122 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.877 0.123 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.876 0.124 0.000
Y40 Systemic antibiotics
0.876 0.124 0.000
E89.0 Postprocedural hypothyroidism
0.875 0.125 0.000
M65 Synovitis and tenosynovitis
0.875 0.125 0.000
M54.9 Dorsalgia, unspecified
0.871 0.129 0.000
T92.2 Sequelae of fracture at wrist and hand level
0.870 0.130 0.000
E11.5 With peripheral circulatory complications
0.870 0.130 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.870 0.130 0.000
M79.67 Pain in limb (Ankle and foot)
0.870 0.130 0.000
O68 Labour and delivery complicated by foetal stress [distress]
0.867 0.133 0.000
G45.9 Transient cerebral ischaemic attack, unspecified
0.865 0.135 0.000
M91-M94 Chondropathies
0.864 0.136 0.000
S90-S99 Injuries to the ankle and foot
0.861 0.139 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.860 0.140 0.000
T92.0 Sequelae of open wound of upper limb
0.859 0.141 0.000
V10-V19 Pedal cyclist injured in transport accident
0.859 0.141 0.000
E16.2 Hypoglycaemia, unspecified
0.859 0.141 0.000
S02.2 Fracture of nasal bones
0.859 0.141 0.000
T92.8 Sequelae of other specified injuries of upper limb
0.857 0.143 0.000
F52 Sexual dysfunction, not caused by organic disorder or disease
0.854 0.146 0.000
E07 Other disorders of thyroid
0.853 0.147 0.000
M79.66 Pain in limb (Lower leg)
0.853 0.147 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.852 0.148 0.000
T92.5 Sequelae of injury of muscle and tendon of upper limb
0.849 0.151 0.000
G35 Multiple sclerosis
0.848 0.152 0.000
G37 Other demyelinating diseases of central nervous system
0.847 0.153 0.000
M53 Other dorsopathies, not elsewhere classified
0.846 0.154 0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.845 0.155 0.000
H10-H13 Disorders of conjunctiva
0.845 0.155 0.000
M87 Osteonecrosis
0.843 0.157 0.000
M89 Other disorders of bone
0.843 0.157 0.000
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.840 0.160 0.000
S02.4 Fracture of malar and maxillary bones
0.840 0.160 0.000
G20-G26 Extrapyramidal and movement disorders
0.839 0.161 0.000
L40-L45 Papulosquamous disorders
0.839 0.161 0.000
S06 Intracranial injury
0.839 0.161 0.000
G40.5 Special epileptic syndromes
0.838 0.162 0.000
M79.7 Fibromyalgia
0.835 0.165 0.000
F60 Specific personality disorders
0.832 0.168 0.000
M80-M85 Disorders of bone density and structure
0.830 0.170 0.000
O20 Haemorrhage in early pregnancy
0.830 0.170 0.000
E86 Volume depletion
0.829 0.171 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.828 0.172 0.000
M65.9 Synovitis and tenosynovitis, unspecified
0.827 0.173 0.000
G30.0 Alzheimer's disease with early onset
0.827 0.173 0.000
E73 Lactose intolerance
0.827 0.173 0.000
T90 Sequelae of injuries of head
0.827 0.173 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.824 0.176 0.000
M79.1 Myalgia
0.824 0.176 0.000
M54.59 Low back pain (Site unspecified)
0.823 0.177 0.000
H20 Iridocyclitis
0.818 0.182 0.000
O48 Prolonged pregnancy
0.817 0.183 0.000
O40 Polyhydramnios
0.817 0.183 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.816 0.184 0.000
M40-M43 Deforming dorsopathies
0.815 0.185 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.815 0.185 0.000
O41 Other disorders of amniotic fluid and membranes
0.814 0.186 0.000
F52.2 Failure of genital response
0.813 0.187 0.000
M00-M03 Infectious arthropathies
0.812 0.188 0.000
O68.1 Labour and delivery complicated by meconium in amniotic fluid
0.812 0.188 0.000
O69.1 Labour and delivery complicated by cord around neck, with compression
0.812 0.188 0.000
M20-M25 Other joint disorders
0.811 0.189 0.000
M48.5 Collapsed vertebra, not elsewhere classified
0.810 0.190 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.809 0.191 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.808 0.192 0.000
V40-V49 Car occupant injured in transport accident
0.807 0.193 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.807 0.193 0.000
G30.9 Alzheimer's disease, unspecified
0.806 0.194 0.000
M48.0 Spinal stenosis
0.806 0.194 0.000
G45.3 Amaurosis fugax
0.805 0.195 0.000
H04 Disorders of lachrymal system
0.805 0.195 0.000
T68 Hypothermia
0.802 0.197 0.000
M90 Osteopathies in diseases classified elsewhere
0.801 0.199 0.000
H11 Other disorders of conjunctiva
0.801 0.199 0.000
M54.4 Lumbago with sciatica
0.800 0.200 0.000
G62 Other polyneuropathies
0.800 0.200 0.000
M60-M63 Disorders of muscles
0.800 0.200 0.000
S22 Fracture of rib(s), sternum and thoracic spine
0.797 0.203 0.000
M79.2 Neuralgia and neuritis, unspecified
0.796 0.204 0.000
T78.1 Other adverse food reactions, not elsewhere classified
0.792 0.208 0.000
S00.2 Other superficial injuries of eyelid and periocular area
0.792 0.208 0.000
E87.3 Alkalosis
0.791 0.209 0.000
M86 Osteomyelitis
0.791 0.209 0.000
E85 Amyloidosis
0.790 0.210 0.000
E04 Other non-toxic goitre
0.789 0.211 0.000
S02.20 Fracture of nasal bones (closed)
0.788 0.212 0.000
M65.94 Synovitis and tenosynovitis, unspecified (Hand)
0.788 0.212 0.000
Y42.3 Insulin and oral hypoglycaemic [antidiabetic] drugs
0.787 0.212 0.000
G40.7 Petit mal, unspecified, without grand mal seizures
0.786 0.214 0.000
L43 Lichen planus
0.786 0.214 0.000
S00.1 Contusion of eyelid and periocular area
0.785 0.215 0.000
S13 Dislocation, sprain and strain of joints and ligaments at neck level
0.785 0.215 0.000
M25 Other joint disorders, not elsewhere classified
0.783 0.217 0.000
L02 Cutaneous abscess, furuncle and carbuncle
0.782 0.218 0.000
E74 Other disorders of carbohydrate metabolism
0.780 0.220 0.000
O61 Failed induction of labour
0.780 0.220 0.000
G46 Vascular syndromes of brain in cerebrovascular diseases
0.780 0.220 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.776 0.224 0.000
T92.3 Sequelae of dislocation, sprain and strain of upper limb
0.776 0.224 0.000
L50-L54 Urticaria and erythema
0.775 0.225 0.000
E11.0 With coma
0.775 0.225 0.000
T20 Burn and corrosion of head and neck
0.773 0.227 0.000
O65 Obstructed labour due to maternal pelvic abnormality
0.772 0.228 0.000
G24 Dystonia
0.772 0.228 0.000
X50-X57 Overexertion, travel and privation
0.772 0.228 0.000
H04.2 Epiphora
0.772 0.228 0.000
O71 Other obstetric trauma
0.771 0.229 0.000
L02.2 Cutaneous abscess, furuncle and carbuncle of trunk
0.770 0.230 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.768 0.232 0.000
G37.9 Demyelinating disease of central nervous system, unspecified
0.768 0.232 0.000
O21 Excessive vomiting in pregnancy
0.767 0.232 0.000
E16.1 Other hypoglycaemia
0.767 0.233 0.000
T13 Other injuries of lower limb, level unspecified
0.766 0.234 0.000
E06 Thyroiditis
0.766 0.234 0.000
S50-S59 Injuries to the elbow and forearm
0.766 0.234 0.000
Y42.0 Glucocorticoids and synthetic analogs
0.765 0.235 0.000
O85-O92 Complications predominantly related to the puerperium
0.765 0.235 0.000
T92.6 Sequelae of crushing injury and traumatic amputation of upper limb
0.764 0.235 0.000
E11.4 With neurological complications
0.764 0.236 0.000
S02.6 Fracture of mandible
0.763 0.237 0.000
T00-T07 Injuries involving multiple body regions
0.763 0.237 0.000
S02.1 Fracture of base of skull
0.763 0.237 0.000
T14 Injury of unspecified body region
0.762 0.238 0.000
S09.9 Unspecified injury of head
0.761 0.239 0.000
T78.0 Anaphylactic shock due to adverse food reaction
0.761 0.239 0.000
E10 Insulin-dependent diabetes mellitus
0.761 0.239 0.000
L20-L30 Dermatitis and eczema
0.760 0.240 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.760 0.240 0.000
S12 Fracture of neck
0.760 0.240 0.000
Y00-Y09 Assault
0.759 0.241 0.000
O00-O08 Pregnancy with abortive outcome
0.759 0.241 0.000
S02.40 Fracture of malar and maxillary bones (closed)
0.757 0.243 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.757 0.243 0.000
T92.9 Sequelae of unspecified injury of upper limb
0.756 0.244 0.000
E11.6 With other specified complications
0.756 0.244 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.755 0.245 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.754 0.245 0.000
M54.16 Radiculopathy (Lumbar region)
0.754 0.246 0.000
G03 Meningitis due to other and unspecified causes
0.753 0.247 0.000
O22 Venous complications in pregnancy
0.752 0.247 0.000
F03 Unspecified dementia
0.751 0.249 0.000
Y57 Other and unspecified drugs and medicaments
0.750 0.250 0.000
M54.17 Radiculopathy (Lumbosacral region)
0.750 0.250 0.000
W10 Fall on and from stairs and steps
0.749 0.251 0.000
M66 Spontaneous rupture of synovium and tendon
0.749 0.251 0.000
T21 Burn and corrosion of trunk
0.749 0.251 0.000
X10-X19 Contact with heat and hot substances
0.748 0.252 0.000
L43.9 Lichen planus, unspecified
0.748 0.252 0.000
V18 Pedal cyclist injured in noncollision transport accident
0.748 0.252 0.000
H33 Retinal detachments and breaks
0.748 0.252 0.000
M46 Other inflammatory spondylopathies
0.747 0.253 0.000
F50 Eating disorders
0.747 0.253 0.000
G70-G73 Diseases of myoneural junction and muscle
0.747 0.253 0.000
M48.9 Spondylopathy, unspecified
0.747 0.253 0.000
T78.4 Allergy, unspecified
0.745 0.255 0.000
X60-X84 Intentional self-harm
0.745 0.255 0.000
M79.64 Pain in limb (Hand)
0.745 0.255 0.000
M87.9 Osteonecrosis, unspecified
0.742 0.258 0.000
W13 Fall from, out of or through building or structure
0.742 0.258 0.000
M89.8 Other specified disorders of bone
0.742 0.258 0.000
S27 Injury of other and unspecified intrathoracic organs
0.741 0.259 0.000
M50 Cervical disk disorders
0.741 0.259 0.000
V80-V89 Other land transport accidents
0.741 0.259 0.000
T98 Sequelae of other and unspecified effects of external causes
0.740 0.260 0.000
M53.3 Sacrococcygeal disorders, not elsewhere classified
0.740 0.260 0.000
H20.8 Other iridocyclitis
0.740 0.260 0.000
F60.7 Dependent personality disorder
0.739 0.261 0.000
H18 Other disorders of cornea
0.738 0.262 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.738 0.262 0.000
W50-W64 Exposure to animate mechanical forces
0.738 0.262 0.000
F80-F89 Disorders of psychological development
0.737 0.263 0.000
Y43 Primarily systemic agents
0.735 0.265 0.000
M54.94 Dorsalgia, unspecified (Thoracic region)
0.734 0.266 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.733 0.267 0.000
M25.8 Other specified joint disorders
0.732 0.268 0.000
T75 Effects of other external causes
0.732 0.268 0.000
L02.3 Cutaneous abscess, furuncle and carbuncle of buttock
0.731 0.269 0.000
M76 Enthesopathies of lower limb, excluding foot
0.731 0.269 0.000
T11 Other injuries of upper limb, level unspecified
0.730 0.270 0.000
F99-F99 Unspecified mental disorder
0.730 0.270 0.000
E40-E46 Malnutrition
0.729 0.271 0.000
S92 Fracture of foot, except ankle
0.728 0.272 0.000
E11.1 With ketoacidosis
0.726 0.274 0.000
M79.18 Myalgia (Other)
0.726 0.274 0.000
S00.3 Superficial injury of nose
0.726 0.274 0.000
O36 Maternal care for other known or suspected foetal problems
0.725 0.275 0.000
V20-V29 Motorcycle rider injured in transport accident
0.725 0.275 0.000
Y48 Anaesthetics and therapeutic gases
0.724 0.276 0.000
S14 Injury of nerves and spinal cord at neck level
0.724 0.276 0.000
S30 Superficial injury of abdomen, lower back and pelvis
0.724 0.276 0.000
M79.79 Fibromyalgia (Site unspecified)
0.723 0.277 0.000
M54.55 Low back pain (Thoracolumbar region)
0.722 0.278 0.000
O70.0 First degree perineal laceration during delivery
0.721 0.279 0.000
E04.9 Non-toxic goitre, unspecified
0.721 0.279 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.720 0.279 0.000
O43 Placental disorders
0.719 0.281 0.000
G31.9 Degenerative disease of nervous system, unspecified
0.719 0.281 0.000
H11.9 Disorder of conjunctiva, unspecified
0.719 0.281 0.000
E07.8 Other specified disorders of thyroid
0.719 0.281 0.000
W03 Other fall on same level due to collision with, or pushing by, another person
0.719 0.281 0.000
S70-S79 Injuries to the hip and thigh
0.718 0.281 0.000
G41 Status epilepticus
0.718 0.282 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
S05 Injury of eye and orbit
0.716 0.284 0.000
Y40.9 Systemic antibiotic, unspecified
0.715 0.285 0.000
Y35-Y36 Legal intervention and operations of war
0.715 0.285 0.000
Y10-Y34 Event of undetermined intent
0.715 0.285 0.000
X85-X99 Assault
0.715 0.285 0.000
X30-X39 Exposure to forces of nature
0.715 0.285 0.000
X00-X09 Exposure to smoke, fire and flames
0.715 0.285 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.715 0.285 0.000
W75-W84 Other accidental threats to breathing
0.715 0.285 0.000
W65-W74 Accidental drowning and submersion
0.715 0.285 0.000
V98-V99 Other and unspecified transport accidents
0.715 0.285 0.000
V95-V97 Air and space transport accidents
0.715 0.285 0.000
V90-V94 Water transport accidents
0.715 0.285 0.000
V70-V79 Bus occupant injured in transport accident
0.715 0.285 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.715 0.285 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.715 0.285 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.715 0.285 0.000
V01-V09 Pedestrian injured in transport accident
0.715 0.285 0.000
Y52.1 Calcium-channel blockers
0.715 0.285 0.000
S39 Other and unspecified injuries of abdomen, lower back and pelvis
0.714 0.286 0.000
S08 Traumatic amputation of part of head
0.714 0.286 0.000
S07 Crushing injury of head
0.714 0.286 0.000
S04 Injury of cranial nerves
0.714 0.286 0.000
W01 Fall on same level from slipping, tripping and stumbling
0.714 0.286 0.000
Y40.0 Penicillins
0.714 0.286 0.000
E12 Malnutrition-related diabetes mellitus
0.713 0.287 0.000
E84 Cystic fibrosis
0.713 0.287 0.000
E79 Disorders of purine and pyrimidine metabolism
0.713 0.287 0.000
E77 Disorders of glycoprotein metabolism
0.713 0.287 0.000
E76 Disorders of glycosaminoglycan metabolism
0.713 0.287 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.713 0.287 0.000
E72 Other disorders of amino-acid metabolism
0.713 0.287 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.713 0.287 0.000
E70 Disorders of aromatic amino-acid metabolism
0.713 0.287 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.713 0.287 0.000
E80.2 Other porphyria
0.713 0.287 0.000
T95 Sequelae of burns, corrosions and frostbite
0.713 0.287 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.713 0.287 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.713 0.287 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.713 0.287 0.000
Y42.8 Other and unspecified hormones and their synthetic substitutes
0.713 0.287 0.000
E11.8 With unspecified complications
0.712 0.288 0.000
E11.7 With multiple complications
0.712 0.288 0.000
L10-L14 Bullous disorders
0.712 0.288 0.000
Y59 Other and unspecified vaccines and biological substances
0.711 0.288 0.000
Y58 Bacterial vaccines
0.711 0.288 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.711 0.288 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.711 0.288 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.711 0.289 0.000
M48.56 Collapsed vertebra, not elsewhere classified (Lumbar region)
0.711 0.289 0.000
H31 Other disorders of choroid
0.711 0.289 0.000
O74 Complications of anaesthesia during labour and delivery
0.711 0.289 0.000
O60 Preterm delivery
0.711 0.289 0.000
M54.8 Other dorsalgia
0.710 0.290 0.000
M54.0 Panniculitis affecting regions of neck and back
0.710 0.290 0.000
G31.8 Other specified degenerative diseases of nervous system
0.710 0.290 0.000
T92.4 Sequelae of injury of nerve of upper limb
0.710 0.290 0.000
M48.07 Spinal stenosis (Lumbosacral region)
0.710 0.290 0.000
H33.2 Serous retinal detachment
0.710 0.290 0.000
M54.2 Cervicalgia
0.710 0.290 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.710 0.290 0.000
S02.0 Fracture of vault of skull
0.710 0.290 0.000
Q00-Q07 Congenital malformations of the nervous system
0.709 0.291 0.000
M54.12 Radiculopathy (Cervical region)
0.709 0.291 0.000
O20.9 Haemorrhage in early pregnancy, unspecified
0.709 0.291 0.000
O70.3 Fourth degree perineal laceration during delivery
0.709 0.291 0.000
Y40.1 Cefalosporins and other -lactam antibiotics
0.708 0.292 0.000
M47 Spondylosis
0.708 0.292 0.000
W06 Fall involving bed
0.708 0.292 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.708 0.292 0.000
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.707 0.293 0.000
S02.3 Fracture of orbital floor
0.706 0.293 0.000
M24 Other specific joint derangements
0.706 0.294 0.000
E73.9 Lactose intolerance, unspecified
0.706 0.294 0.000
F60.3 Emotionally unstable personality disorder
0.706 0.294 0.000
W14 Fall from tree
0.704 0.296 0.000
Y51.7 Beta-Adrenoreceptor antagonists, not elsewhere classified
0.704 0.296 0.000
M54.54 Low back pain-Thoracic
0.703 0.296 0.000
M54.53 Low back pain-Cervicothoracic
0.703 0.296 0.000
M54.52 Low back pain-Cervical
0.703 0.296 0.000
M54.51 Low back pain-Occipit-atl-axl
0.703 0.296 0.000
O24 Diabetes mellitus in pregnancy
0.703 0.297 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.703 0.297 0.000
G40.4 Other generalised epilepsy and epileptic syndromes
0.702 0.298 0.000
G40.0 Localisation-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localised onset
0.702 0.298 0.000
F00 Dementia in Alzheimer's disease
0.702 0.298 0.000
G62.8 Other specified polyneuropathies
0.702 0.298 0.000
T74 Maltreatment syndromes
0.702 0.298 0.000
T73 Effects of other deprivation
0.702 0.298 0.000
T70 Effects of air pressure and water pressure
0.702 0.298 0.000
T69 Other effects of reduced temperature
0.702 0.298 0.000
T67 Effects of heat and light
0.702 0.298 0.000
T71 Asphyxiation
0.702 0.298 0.000
T66 Unspecified effects of radiation
0.702 0.298 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.701 0.299 0.000
G40.8 Other epilepsy
0.701 0.299 0.000
S09.0 Injury of blood vessels of head, not elsewhere classified
0.700 0.300 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.700 0.300 0.000
E00 Congenital iodine-deficiency syndrome
0.700 0.300 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.700 0.300 0.000
S20 Superficial injury of thorax
0.700 0.300 0.000
W07 Fall involving chair
0.700 0.300 0.000
T24 Burn and corrosion of hip and lower limb, except ankle and foot
0.699 0.301 0.000
E80.4 Gilbert's syndrome
0.699 0.301 0.000
O41.8 Other specified disorders of amniotic fluid and membranes
0.699 0.301 0.000
G24.9 Dystonia, unspecified
0.698 0.302 0.000
S00.5 Superficial injury of lip and oral cavity
0.697 0.303 0.000
O23 Infections of genito-urinary tract in pregnancy
0.697 0.303 0.000
G61 Inflammatory polyneuropathy
0.697 0.303 0.000
M25.5 Pain in joint
0.697 0.303 0.000
O29 Complications of anaesthesia during pregnancy
0.695 0.304 0.000
O25 Malnutrition in pregnancy
0.695 0.304 0.000
E07.9 Disorder of thyroid, unspecified
0.695 0.305 0.000
O44 Placenta praevia
0.695 0.305 0.000
G40.3 Generalised idiopathic epilepsy and epileptic syndromes
0.695 0.305 0.000
G37.8 Other specified demyelinating diseases of central nervous system
0.695 0.305 0.000
S22.2 Fracture of sternum
0.695 0.305 0.000
O45 Premature separation of placenta [abruptio placentae]
0.695 0.305 0.000
M54.98 Dorsalgia, unspecified (Sacral and sacrococcygeal region)
0.694 0.306 0.000
O73 Retained placenta and membranes, without haemorrhage
0.694 0.306 0.000
W05 Fall involving wheelchair
0.694 0.306 0.000
M43 Other deforming dorsopathies
0.694 0.306 0.000
G32 Other degenerative disorders of nervous system in diseases classified elsewhere
0.694 0.306 0.000
Y42.9 Other and unspecified hormone antagonists
0.693 0.307 0.000
Y42.4 Oral contraceptives
0.693 0.307 0.000
Y42.2 Antithyroid drugs
0.693 0.307 0.000
Y42.1 Thyroid hormones and substitutes
0.693 0.307 0.000
M93 Other osteochondropathies
0.693 0.307 0.000
O46 Antepartum haemorrhage, not elsewhere classified
0.693 0.307 0.000
E87.4 Mixed disorder of acid-base balance
0.693 0.307 0.000
M65.8 Other synovitis and tenosynovitis
0.693 0.307 0.000
L27 Dermatitis due to substances taken internally
0.692 0.308 0.000
T23 Burn and corrosion of wrist and hand
0.692 0.308 0.000
S06.6 Traumatic subarachnoid haemorrhage
0.691 0.309 0.000
M65.91 Synovitis and tenosynovitis, unspecified (Shoulder region)
0.691 0.309 0.000
S06.0 Concussion
0.691 0.309 0.000
Y52.3 Coronary vasodilators, not elsewhere classified
0.690 0.310 0.000
S31 Open wound of abdomen, lower back and pelvis
0.690 0.310 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.689 0.311 0.000
F70-F79 Mental retardation
0.689 0.311 0.000
M71 Other bursopathies
0.689 0.311 0.000
H04.9 Disorder of lachrymal system, unspecified
0.689 0.311 0.000
S90 Superficial injury of ankle and foot
0.688 0.312 0.000
M54.6 Pain in thoracic spine
0.688 0.312 0.000
F02 Dementia in other diseases classified elsewhere
0.687 0.313 0.000
M48.06 Spinal stenosis (Lumbar region)
0.687 0.313 0.000
M49 Spondylopathies in diseases classified elsewhere
0.686 0.313 0.000
S10 Superficial injury of neck
0.686 0.313 0.000
M92 Other juvenile osteochondrosis
0.686 0.314 0.000
S02.9 Fracture of skull and facial bones, part unspecified
0.686 0.314 0.000
S02.7 Multiple fractures involving skull and facial bones
0.686 0.314 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.686 0.314 0.000
Y52.2 Other antidysrhythmic drugs, not elsewhere classified
0.685 0.315 0.000
M90.7 Fracture of bone in neoplastic disease
0.685 0.315 0.000
V18.0 Driver injured in nontraffic accident
0.685 0.315 0.000
O30 Multiple gestation
0.685 0.315 0.000
S00.8 Superficial injury of other parts of head
0.685 0.315 0.000
O70.9 Perineal laceration during delivery, unspecified
0.684 0.316 0.000
M80 Osteoporosis with pathological fracture
0.684 0.316 0.000
T78.9 Adverse effect, unspecified
0.682 0.318 0.000
T78.8 Other adverse effects, not elsewhere classified
0.682 0.318 0.000
X20-X29 Contact with venomous animals and plants
0.682 0.318 0.000
G36 Other acute disseminated demyelination
0.680 0.320 0.000
M79.5 Residual foreign body in soft tissue
0.679 0.321 0.000
E15 Nondiabetic hypoglycaemic coma
0.679 0.321 0.000
M54.19 Radiculopathy (Site unspecified)
0.678 0.322 0.000
M79.9 Soft tissue disorder, unspecified
0.678 0.322 0.000
M79.3 Panniculitis, unspecified
0.678 0.322 0.000
H11.8 Other specified disorders of conjunctiva
0.678 0.322 0.000
T22 Burn and corrosion of shoulder and upper limb, except wrist and hand
0.678 0.322 0.000
M00 Pyogenic arthritis
0.677 0.323 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.677 0.323 0.000
E20-E35 Disorders of other endocrine glands
0.677 0.323 0.000
O68.8 Labour and delivery complicated by other evidence of foetal stress
0.676 0.324 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.676 0.324 0.000
M25.56 Pain in joint (Lower leg)
0.675 0.325 0.000
Y40.3 Macrolides
0.675 0.325 0.000
O20.8 Other haemorrhage in early pregnancy
0.675 0.325 0.000
G00 Bacterial meningitis, not elsewhere classified
0.675 0.325 0.000
H11.1 Conjunctival degenerations and deposits
0.674 0.326 0.000
M94 Other disorders of cartilage
0.673 0.327 0.000
L53 Other erythematous conditions
0.673 0.327 0.000
M25.3 Other instability of joint
0.672 0.327 0.000
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
0.671 0.329 0.000
E65-E68 Obesity and other hyperalimentation
0.671 0.329 0.000
M54.57 Low back pain (Lumbosacral region)
0.671 0.329 0.000
M25.86 Other specified joint disorders (Lower leg)
0.670 0.330 0.000
O33 Maternal care for known or suspected disproportion
0.670 0.330 0.000
O31 Complications specific to multiple gestation
0.670 0.330 0.000
G03.9 Meningitis, unspecified
0.669 0.331 0.000
S99 Other and unspecified injuries of ankle and foot
0.669 0.331 0.000
M79.70 Fibromyalgia (Multiple sites)
0.669 0.331 0.000
S06.2 Diffuse brain injury
0.669 0.331 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.668 0.332 0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.668 0.332 0.000
M77 Other enthesopathies
0.668 0.332 0.000
O12 Gestational [pregnancy-induced] oedema and proteinuria without hypertension
0.667 0.333 0.000
M86.9 Osteomyelitis, unspecified
0.667 0.333 0.000
M48.55 Collapsed vertebra, not elsewhere classified (Thoracolumbar region)
0.667 0.333 0.000
G45.8 Other transient cerebral ischaemic attacks and related syndromes
0.666 0.334 0.000
E03.5 Myxoedema coma
0.666 0.334 0.000
E03.4 Atrophy of thyroid (acquired)
0.666 0.334 0.000
E03.3 Postinfectious hypothyroidism
0.666 0.334 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.666 0.334 0.000
E03.1 Congenital hypothyroidism without goitre
0.666 0.334 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.666 0.334 0.000
E13 Other specified diabetes mellitus
0.666 0.334 0.000
E03.8 Other specified hypothyroidism
0.665 0.335 0.000
M54.46 Lumbago with sciatica (Lumbar region)
0.665 0.335 0.000
M70.6 Trochanteric bursitis
0.665 0.335 0.000
S13.4 Sprain and strain of cervical spine
0.664 0.336 0.000
M79.68 Pain in limb (Other)
0.664 0.336 0.000
G45.2 Multiple and bilateral precerebral artery syndromes
0.664 0.336 0.000
G45.1 Carotid artery syndrome (hemispheric)
0.664 0.336 0.000
G45.0 Vertebro-basilar artery syndrome
0.664 0.336 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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