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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs7296313
log Bayes Factor = 21.6862
Chromosome 12   position 111,878,526  (GRCh37) Explore rs7296313 on Ensembl!
Variant rs7296313 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
I21 Acute myocardial infarction
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
I10 Essential (primary) hypertension
0.000 0.000 1.000
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.000 1.000
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.001 0.999
E03 Other hypothyroidism
0.000 0.002 0.998
E00-E07 Disorders of thyroid gland
0.000 0.003 0.997
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.003 0.997
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.007 0.993
E20-E35 Disorders of other endocrine glands
0.000 0.007 0.993
I10-I15 Hypertensive diseases
0.000 0.008 0.992
Z95.5 Presence of coronary angioplasty implant and graft
0.000 0.009 0.991
Chapter IX Diseases of the circulatory system
0.000 0.009 0.991
Z95 Presence of cardiac and vascular implants and grafts
0.000 0.009 0.991
Z95.1 Presence of aortocoronary bypass graft
0.000 0.010 0.990
E27 Other disorders of adrenal gland
0.000 0.012 0.988
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.021 0.979
E05.9 Thyrotoxicosis, unspecified
0.000 0.027 0.973
E27.1 Primary adrenocortical insufficiency
0.000 0.036 0.964
I22 Subsequent myocardial infarction
0.000 0.039 0.961
E10-E14 Diabetes mellitus
0.000 0.044 0.956
E10 Insulin-dependent diabetes mellitus
0.000 0.047 0.953
Z95.3 Presence of xenogenic heart valve
0.000 0.049 0.951
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.053 0.947
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.062 0.938
I30-I52 Other forms of heart disease
0.000 0.064 0.936
I25.5 Ischaemic cardiomyopathy
0.000 0.064 0.936
I49 Other cardiac arrhythmias
0.000 0.067 0.933
I49.9 Cardiac arrhythmia, unspecified
0.000 0.072 0.928
I35 Nonrheumatic aortic valve disorders
0.000 0.074 0.926
E10.9 Without complications
0.000 0.085 0.915
I49.3 Ventricular premature depolarisation
0.000 0.086 0.914
I35.0 Aortic (valve) stenosis
0.000 0.087 0.913
E10.3 With ophthalmic complications
0.000 0.088 0.912
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.100 0.900
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.100 0.900
E23 Hypofunction and other disorders of pituitary gland
0.000 0.108 0.892
I35.2 Aortic (valve) stenosis with insufficiency
0.000 0.114 0.886
I21.9 Acute myocardial infarction, unspecified
0.000 0.123 0.877
E50-E64 Other nutritional deficiencies
0.000 0.128 0.872
I99 Other and unspecified disorders of circulatory system
0.000 0.133 0.867
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.135 0.865
E28 Ovarian dysfunction
0.000 0.136 0.864
I47 Paroxysmal tachycardia
0.000 0.138 0.862
I25.2 Old myocardial infarction
0.000 0.140 0.860
Z95.2 Presence of prosthetic heart valve
0.000 0.158 0.842
E27.8 Other specified disorders of adrenal gland
0.000 0.161 0.839
I47.2 Ventricular tachycardia
0.000 0.163 0.837
E21.0 Primary hyperparathyroidism
0.000 0.173 0.827
I42 Cardiomyopathy
0.000 0.178 0.822
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.179 0.821
I97.1 Other functional disturbances following cardiac surgery
0.000 0.181 0.819
E23.2 Diabetes insipidus
0.000 0.188 0.812
I20 Angina pectoris
0.000 0.209 0.791
I23 Certain current complications following acute myocardial infarction
0.000 0.212 0.788
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.219 0.781
E27.2 Addisonian crisis
0.000 0.220 0.780
E10.4 With neurological complications
0.000 0.220 0.780
E22 Hyperfunction of pituitary gland
0.000 0.221 0.779
E10.5 With peripheral circulatory complications
0.000 0.221 0.779
I20.8 Other forms of angina pectoris
0.000 0.224 0.776
Z95.4 Presence of other heart-valve replacement
0.000 0.225 0.775
E34 Other endocrine disorders
0.000 0.225 0.775
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.226 0.774
Z95.8 Presence of other cardiac and vascular implants and grafts
0.000 0.226 0.774
E10.0 With coma
0.000 0.229 0.771
E06 Thyroiditis
0.000 0.231 0.769
I49.0 Ventricular fibrillation and flutter
0.000 0.236 0.764
I97.2 Postmastectomy lymphoedema syndrome
0.000 0.243 0.757
E03.8 Other specified hypothyroidism
0.000 0.249 0.751
I50 Heart failure
0.000 0.250 0.750
E61 Deficiency of other nutrient elements
0.000 0.251 0.749
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.255 0.745
I47.9 Paroxysmal tachycardia, unspecified
0.000 0.255 0.745
I25.4 Coronary artery aneurysm
0.000 0.258 0.742
E28.2 Polycystic ovarian syndrome
0.000 0.263 0.737
I24 Other acute ischaemic heart diseases
0.000 0.276 0.723
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.278 0.722
I98 Other disorders of circulatory system in diseases classified elsewhere
0.000 0.279 0.721
I25.3 Aneurysm of heart
0.000 0.281 0.719
I42.9 Cardiomyopathy, unspecified
0.000 0.282 0.718
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.285 0.715
E03.4 Atrophy of thyroid (acquired)
0.000 0.285 0.715
E03.3 Postinfectious hypothyroidism
0.000 0.285 0.715
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.285 0.715
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.285 0.715
E00 Congenital iodine-deficiency syndrome
0.000 0.285 0.715
I97.8 Other postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.285 0.715
E53 Deficiency of other B group vitamins
0.000 0.288 0.712
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.288 0.712
E32 Diseases of thymus
0.000 0.288 0.712
E31 Polyglandular dysfunction
0.000 0.288 0.712
E30 Disorders of puberty, not elsewhere classified
0.000 0.288 0.712
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.289 0.711
I13 Hypertensive heart and renal disease
0.000 0.289 0.711
I00-I02 Acute rheumatic fever
0.000 0.289 0.711
E27.5 Adrenomedullary hyperfunction
0.000 0.291 0.709
E27.0 Other adrenocortical overactivity
0.000 0.291 0.709
E23.6 Other disorders of pituitary gland
0.000 0.292 0.708
E10.2 With renal complications
0.000 0.297 0.703
E05.5 Thyroid crisis or storm
0.000 0.298 0.702
E05.4 Thyrotoxicosis factitia
0.000 0.298 0.702
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.298 0.702
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.298 0.702
E10.8 With unspecified complications
0.000 0.300 0.700
E27.9 Disorder of adrenal gland, unspecified
0.000 0.302 0.698
I42.1 Obstructive hypertrophic cardiomyopathy
0.000 0.302 0.698
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.305 0.695
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.305 0.695
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.305 0.695
Z95.0 Presence of cardiac pacemaker
0.000 0.306 0.694
E10.6 With other specified complications
0.000 0.307 0.693
E20 Hypoparathyroidism
0.000 0.308 0.692
E12 Malnutrition-related diabetes mellitus
0.000 0.315 0.685
E28.3 Primary ovarian failure
0.000 0.315 0.684
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.319 0.681
E23.7 Disorder of pituitary gland, unspecified
0.000 0.327 0.673
I52 Other heart disorders in diseases classified elsewhere
0.000 0.329 0.671
I48 Atrial fibrillation and flutter
0.000 0.329 0.671
I43 Cardiomyopathy in diseases classified elsewhere
0.000 0.329 0.671
I41 Myocarditis in diseases classified elsewhere
0.000 0.329 0.671
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.000 0.329 0.671
I32 Pericarditis in diseases classified elsewhere
0.000 0.329 0.671
I22.8 Subsequent myocardial infarction of other sites
0.000 0.329 0.671
I49.2 Junctional premature depolarisation
0.000 0.331 0.669
I37 Pulmonary valve disorders
0.000 0.335 0.665
E10.1 With ketoacidosis
0.000 0.336 0.664
E06.9 Thyroiditis, unspecified
0.000 0.338 0.662
I42.0 Dilated cardiomyopathy
0.000 0.339 0.661
I24.8 Other forms of acute ischaemic heart disease
0.000 0.345 0.655
E25 Adrenogenital disorders
0.000 0.348 0.652
I33 Acute and subacute endocarditis
0.000 0.351 0.649
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.354 0.646
I97.9 Postprocedural disorder of circulatory system, unspecified
0.000 0.355 0.645
I97.0 Postcardiotomy syndrome
0.000 0.355 0.645
E21.4 Other specified disorders of parathyroid gland
0.000 0.355 0.645
E21.2 Other hyperparathyroidism
0.000 0.355 0.645
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.360 0.639
E23.1 Drug-induced hypopituitarism
0.000 0.360 0.639
I23.8 Other current complications following acute myocardial infarction
0.000 0.364 0.636
E26 Hyperaldosteronism
0.000 0.366 0.634
I50.1 Left ventricular failure
0.000 0.369 0.631
E03.1 Congenital hypothyroidism without goitre
0.000 0.370 0.630
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.371 0.628
E21.3 Hyperparathyroidism, unspecified
0.000 0.374 0.626
E05.8 Other thyrotoxicosis
0.000 0.374 0.625
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.374 0.625
E63 Other nutritional deficiencies
0.000 0.374 0.625
E56 Other vitamin deficiencies
0.000 0.374 0.625
E51 Thiamine deficiency
0.000 0.374 0.625
E50 Vitamin A deficiency
0.000 0.374 0.625
E60 Dietary zinc deficiency
0.000 0.374 0.625
E59 Dietary selenium deficiency
0.000 0.374 0.625
E58 Dietary calcium deficiency
0.000 0.374 0.625
E54 Ascorbic acid deficiency
0.000 0.374 0.625
E52 Niacin deficiency [pellagra]
0.000 0.374 0.625
E61.1 Iron deficiency
0.000 0.375 0.625
E34.9 Endocrine disorder, unspecified
0.000 0.380 0.620
I21.4 Acute subendocardial myocardial infarction
0.000 0.380 0.620
E28.9 Ovarian dysfunction, unspecified
0.000 0.381 0.619
E28.8 Other ovarian dysfunction
0.000 0.381 0.619
E28.1 Androgen excess
0.000 0.381 0.619
E28.0 Oestrogen excess
0.000 0.381 0.619
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.389 0.611
I42.2 Other hypertrophic cardiomyopathy
0.000 0.392 0.608
E07 Other disorders of thyroid
0.000 0.394 0.606
E55 Vitamin D deficiency
0.000 0.396 0.603
E61.2 Magnesium deficiency
0.000 0.400 0.600
I49.4 Other and unspecified premature depolarisation
0.000 0.402 0.598
I35.8 Other aortic valve disorders
0.000 0.410 0.590
I42.5 Other restrictive cardiomyopathy
0.000 0.410 0.590
I42.4 Endocardial fibroelastosis
0.000 0.410 0.590
I42.3 Endomyocardial (eosinophilic) disease
0.000 0.410 0.590
I36 Nonrheumatic tricuspid valve disorders
0.000 0.419 0.581
I35.9 Aortic valve disorder, unspecified
0.000 0.419 0.581
I42.6 Alcoholic cardiomyopathy
0.000 0.421 0.579
I11 Hypertensive heart disease
0.000 0.427 0.573
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.428 0.572
I50.9 Heart failure, unspecified
0.000 0.432 0.568
E53.8 Deficiency of other specified B group vitamins
0.000 0.433 0.567
E34.0 Carcinoid syndrome
0.000 0.433 0.567
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.435 0.565
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.435 0.565
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.435 0.565
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.435 0.565
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.435 0.565
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.435 0.565
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.435 0.565
E14 Unspecified diabetes mellitus
0.000 0.437 0.563
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.441 0.559
E22.8 Other hyperfunction of pituitary gland
0.000 0.441 0.559
I47.0 Reentry ventricular arrhythmia
0.000 0.441 0.559
E34.5 Androgen resistance syndrome
0.000 0.445 0.555
E34.4 Constitutional tall stature
0.000 0.445 0.555
E34.3 Short stature, not elsewhere classified
0.000 0.445 0.555
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.445 0.555
E34.1 Other hypersecretion of intestinal hormones
0.000 0.445 0.555
E53.9 Vitamin B deficiency, unspecified
0.000 0.447 0.553
E06.4 Drug-induced thyroiditis
0.000 0.449 0.551
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.449 0.551
E06.1 Subacute thyroiditis
0.000 0.449 0.551
E06.0 Acute thyroiditis
0.000 0.449 0.551
E22.1 Hyperprolactinaemia
0.000 0.450 0.550
I15 Secondary hypertension
0.000 0.453 0.547
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere
0.000 0.453 0.547
E40-E46 Malnutrition
0.000 0.457 0.543
E34.8 Other specified endocrine disorders
0.000 0.459 0.541
E24 Cushing's syndrome
0.000 0.460 0.539
E61.9 Deficiency of nutrient element, unspecified
0.000 0.463 0.537
E61.8 Deficiency of other specified nutrient elements
0.000 0.463 0.537
E61.7 Deficiency of multiple nutrient elements
0.000 0.463 0.537
E61.6 Vanadium deficiency
0.000 0.463 0.537
E61.5 Molybdenum deficiency
0.000 0.463 0.537
E61.4 Chromium deficiency
0.000 0.463 0.537
E61.3 Manganese deficiency
0.000 0.463 0.537
E61.0 Copper deficiency
0.000 0.463 0.537
I24.1 Dressler's syndrome
0.000 0.463 0.537
E29 Testicular dysfunction
0.000 0.467 0.532
Z95.9 Presence of cardiac and vascular implant and graft, unspecified
0.000 0.468 0.531
I98.2 Oesophageal varices in diseases classified elsewhere
0.000 0.469 0.531
E23.0 Hypopituitarism
0.000 0.471 0.529
I49.5 Sick sinus syndrome
0.000 0.473 0.527
I40 Acute myocarditis
0.000 0.474 0.525
E06.3 Autoimmune thyroiditis
0.000 0.478 0.522
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.481 0.519
E10.7 With multiple complications
0.000 0.481 0.518
I98.8 Other specified disorders of circulatory system in diseases classified elsewhere
0.000 0.483 0.517
I98.1 Cardiovascular disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.483 0.517
I98.0 Cardiovascular syphilis
0.000 0.483 0.517
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.487 0.512
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.487 0.512
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.487 0.512
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.487 0.512
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.487 0.512
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.487 0.512
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.487 0.512
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.487 0.512
E53.1 Pyridoxine deficiency
0.000 0.489 0.511
E53.0 Riboflavin deficiency
0.000 0.489 0.511
E30.9 Disorder of puberty, unspecified
0.000 0.489 0.510
E30.8 Other disorders of puberty
0.000 0.489 0.510
E30.1 Precocious puberty
0.000 0.489 0.510
E30.0 Delayed puberty
0.000 0.489 0.510
E31.9 Polyglandular dysfunction, unspecified
0.000 0.489 0.510
E31.8 Other polyglandular dysfunction
0.000 0.489 0.510
E31.1 Polyglandular hyperfunction
0.000 0.489 0.510
E31.0 Autoimmune polyglandular failure
0.000 0.489 0.510
E32.9 Disease of thymus, unspecified
0.000 0.489 0.510
E32.8 Other diseases of thymus
0.000 0.489 0.510
E32.1 Abscess of thymus
0.000 0.489 0.510
E32.0 Persistent hyperplasia of thymus
0.000 0.489 0.510
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.489 0.510
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.489 0.510
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.489 0.510
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.490 0.510
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.490 0.510
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.490 0.510
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.490 0.510
I02 Rheumatic chorea
0.000 0.490 0.510
I01 Rheumatic fever with heart involvement
0.000 0.490 0.510
I00 Rheumatic fever without mention of heart involvement
0.000 0.490 0.510
E15 Nondiabetic hypoglycaemic coma
0.000 0.502 0.498
E13 Other specified diabetes mellitus
0.000 0.503 0.497
E20.8 Other hypoparathyroidism
0.000 0.503 0.496
E20.1 Pseudohypoparathyroidism
0.000 0.503 0.496
E20.0 Idiopathic hypoparathyroidism
0.000 0.503 0.496
E12.9 Without complications
0.000 0.509 0.491
E12.8 With unspecified complications
0.000 0.509 0.491
E12.7 With multiple complications
0.000 0.509 0.491
E12.6 With other specified complications
0.000 0.509 0.491
E12.5 With peripheral circulatory complications
0.000 0.509 0.491
E12.4 With neurological complications
0.000 0.509 0.491
E12.3 With ophthalmic complications
0.000 0.509 0.491
E12.2 With renal complications
0.000 0.509 0.491
E12.1 With ketoacidosis
0.000 0.509 0.491
E12.0 With coma
0.000 0.509 0.491
I32.8 Pericarditis in other diseases classified elsewhere
0.000 0.519 0.481
I32.1 Pericarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.519 0.481
I32.0 Pericarditis in bacterial diseases classified elsewhere
0.000 0.519 0.481
I39.8 Endocarditis, valve unspecified, in diseases classified elsewhere
0.000 0.519 0.481
I39.4 Multiple valve disorders in diseases classified elsewhere
0.000 0.519 0.481
I39.3 Pulmonary valve disorders in diseases classified elsewhere
0.000 0.519 0.481
I39.2 Tricuspid valve disorders in diseases classified elsewhere
0.000 0.519 0.481
I39.1 Aortic valve disorders in diseases classified elsewhere
0.000 0.519 0.481
I39.0 Mitral valve disorders in diseases classified elsewhere
0.000 0.519 0.481
I41.8 Myocarditis in other diseases classified elsewhere
0.000 0.519 0.481
I41.2 Myocarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.519 0.481
I41.1 Myocarditis in viral diseases classified elsewhere
0.000 0.519 0.481
I41.0 Myocarditis in bacterial diseases classified elsewhere
0.000 0.519 0.481
I43.8 Cardiomyopathy in other diseases classified elsewhere
0.000 0.519 0.481
I43.2 Cardiomyopathy in nutritional diseases
0.000 0.519 0.481
I43.1 Cardiomyopathy in metabolic diseases
0.000 0.519 0.481
I43.0 Cardiomyopathy in infectious and parasitic diseases classified elsewhere
0.000 0.519 0.481
I48.9 Atrial fibrillation and atrial flutter, unspecified
0.000 0.519 0.481
I48.4 Atypical atrial flutter
0.000 0.519 0.481
I48.3 Typical atrial flutter
0.000 0.519 0.481
I48.2 Chronic atrial fibrillation
0.000 0.519 0.481
I48.1 Persistent atrial fibrillation
0.000 0.519 0.481
I48.0 Paroxysmal atrial fibrillation
0.000 0.519 0.481
I52.8 Other heart disorders in other diseases classified elsewhere
0.000 0.519 0.481
I52.1 Other heart disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.519 0.481
I52.0 Other heart disorders in bacterial diseases classified elsewhere
0.000 0.519 0.481
I42.8 Other cardiomyopathies
0.000 0.519 0.481
E16 Other disorders of pancreatic internal secretion
0.000 0.519 0.480
I37.9 Pulmonary valve disorder, unspecified
0.000 0.523 0.477
I37.8 Other pulmonary valve disorders
0.000 0.523 0.477
I37.2 Pulmonary valve stenosis with insufficiency
0.000 0.523 0.477
I37.0 Pulmonary valve stenosis
0.000 0.523 0.477
E20.9 Hypoparathyroidism, unspecified
0.000 0.523 0.477
I42.7 Cardiomyopathy due to drugs and other external agents
0.000 0.523 0.477
E06.5 Other chronic thyroiditis
0.000 0.524 0.476
I50.0 Congestive heart failure
0.000 0.527 0.473
I37.1 Pulmonary valve insufficiency
0.000 0.529 0.471
E25.9 Adrenogenital disorder, unspecified
0.000 0.532 0.467
E25.8 Other adrenogenital disorders
0.000 0.532 0.467
I33.9 Acute endocarditis, unspecified
0.000 0.535 0.465
E26.8 Other hyperaldosteronism
0.000 0.545 0.455
E26.1 Secondary hyperaldosteronism
0.000 0.545 0.455
I30 Acute pericarditis
0.001 0.548 0.451
I49.1 Atrial premature depolarisation
0.000 0.549 0.451
E50.9 Vitamin A deficiency, unspecified
0.000 0.551 0.448
E50.8 Other manifestations of vitamin A deficiency
0.000 0.551 0.448
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.551 0.448
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.551 0.448
E50.5 Vitamin A deficiency with night blindness
0.000 0.551 0.448
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.551 0.448
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.551 0.448
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.551 0.448
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.551 0.448
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.551 0.448
E51.9 Thiamine deficiency, unspecified
0.000 0.551 0.448
E51.8 Other manifestations of thiamine deficiency
0.000 0.551 0.448
E51.2 Wernicke's encephalopathy
0.000 0.551 0.448
E51.1 Beriberi
0.000 0.551 0.448
E56.9 Vitamin deficiency, unspecified
0.000 0.551 0.448
E56.8 Deficiency of other vitamins
0.000 0.551 0.448
E56.1 Deficiency of vitamin K
0.000 0.551 0.448
E56.0 Deficiency of vitamin E
0.000 0.551 0.448
E63.9 Nutritional deficiency, unspecified
0.000 0.551 0.448
E63.8 Other specified nutritional deficiencies
0.000 0.551 0.448
E63.1 Imbalance of constituents of food intake
0.000 0.551 0.448
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.551 0.448
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.551 0.448
E64.8 Sequelae of other nutritional deficiencies
0.000 0.551 0.448
E64.3 Sequelae of rickets
0.000 0.551 0.448
E64.2 Sequelae of vitamin C deficiency
0.000 0.551 0.448
E64.1 Sequelae of vitamin A deficiency
0.000 0.551 0.448
E64.0 Sequelae of protein-energy malnutrition
0.000 0.551 0.448
I33.0 Acute and subacute infective endocarditis
0.000 0.557 0.443
E14.4 With neurological complications
0.000 0.563 0.436
E14.3 With ophthalmic complications
0.000 0.565 0.435
E07.1 Dyshormogenetic goitre
0.000 0.565 0.435
E07.0 Hypersecretion of calcitonin
0.000 0.565 0.435
E55.0 Rickets, active
0.000 0.567 0.433
E26.9 Hyperaldosteronism, unspecified
0.000 0.571 0.429
I05-I09 Chronic rheumatic heart diseases
0.000 0.573 0.427
E14.6 With other specified complications
0.000 0.574 0.425
E14.1 With ketoacidosis
0.000 0.578 0.422
I20.0 Unstable angina
0.000 0.579 0.421
I36.9 Nonrheumatic tricuspid valve disorder, unspecified
0.000 0.583 0.417
I36.8 Other nonrheumatic tricuspid valve disorders
0.000 0.583 0.417
I36.2 Nonrheumatic tricuspid (valve) stenosis with insufficiency
0.000 0.583 0.417
I36.0 Nonrheumatic tricuspid (valve) stenosis
0.000 0.583 0.417
E55.9 Vitamin D deficiency, unspecified
0.000 0.589 0.411
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.589 0.410
E26.0 Primary hyperaldosteronism
0.000 0.590 0.410
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.592 0.407
E14.5 With peripheral circulatory complications
0.000 0.596 0.404
E14.7 With multiple complications
0.000 0.596 0.404
E14.2 Withrenal complications
0.000 0.596 0.404
E14.0 With coma
0.000 0.596 0.404
E07.8 Other specified disorders of thyroid
0.000 0.602 0.398
E22.0 Acromegaly and pituitary gigantism
0.000 0.606 0.394
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.607 0.393
I15.8 Other secondary hypertension
0.000 0.607 0.392
I15.2 Hypertension secondary to endocrine disorders
0.000 0.607 0.392
I15.0 Renovascular hypertension
0.000 0.607 0.392
E24.0 Pituitary-dependent Cushing's disease
0.000 0.608 0.392
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.610 0.389
E45 Retarded development following protein-energy malnutrition
0.000 0.610 0.389
E43 Unspecified severe protein-energy malnutrition
0.000 0.610 0.389
E42 Marasmic kwashiorkor
0.000 0.610 0.389
E41 Nutritional marasmus
0.000 0.610 0.389
E40 Kwashiorkor
0.000 0.610 0.389
I38 Endocarditis, valve unspecified
0.000 0.612 0.387
E16.1 Other hypoglycaemia
0.000 0.613 0.387
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.613 0.387
E24.3 Ectopic ACTH syndrome
0.000 0.613 0.387
E24.1 Nelson's syndrome
0.000 0.613 0.387
I35.1 Aortic (valve) insufficiency
0.000 0.618 0.382
E29.9 Testicular dysfunction, unspecified
0.000 0.618 0.382
E29.8 Other testicular dysfunction
0.000 0.618 0.382
E29.0 Testicular hyperfunction
0.000 0.618 0.382
I40.8 Other acute myocarditis
0.000 0.623 0.377
I40.1 Isolated myocarditis
0.000 0.623 0.377
E07.9 Disorder of thyroid, unspecified
0.000 0.625 0.375
E65-E68 Obesity and other hyperalimentation
0.000 0.630 0.370
I01.9 Acute rheumatic heart disease, unspecified
0.000 0.634 0.365
I01.8 Other acute rheumatic heart disease
0.000 0.634 0.365
I01.2 Acute rheumatic myocarditis
0.000 0.634 0.365
I01.1 Acute rheumatic endocarditis
0.000 0.634 0.365
I01.0 Acute rheumatic pericarditis
0.000 0.634 0.365
I02.9 Rheumatic chorea without heart involvement
0.000 0.634 0.365
I02.0 Rheumatic chorea with heart involvement
0.000 0.634 0.365
I40.9 Acute myocarditis, unspecified
0.001 0.642 0.357
E13.8 With unspecified complications
0.000 0.644 0.356
E13.7 With multiple complications
0.000 0.644 0.356
E13.6 With other specified complications
0.000 0.644 0.356
E13.5 With peripheral circulatory complications
0.000 0.644 0.356
E13.4 With neurological complications
0.000 0.644 0.356
E13.2 With renal complications
0.000 0.644 0.356
E13.1 With ketoacidosis
0.000 0.644 0.356
E13.0 With coma
0.000 0.644 0.356
E24.2 Drug-induced Cushing's syndrome
0.000 0.644 0.355
I20.1 Angina pectoris with documented spasm
0.000 0.650 0.350
E24.8 Other Cushing's syndrome
0.000 0.652 0.347
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.655 0.345
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.655 0.345
E16.4 Abnormal secretion of gastrin
0.000 0.655 0.345
E16.3 Increased secretion of glucagon
0.000 0.655 0.345
I12 Hypertensive renal disease
0.000 0.657 0.343
I31 Other diseases of pericardium
0.000 0.659 0.341
I45 Other conduction disorders
0.000 0.665 0.335
I15.9 Seconday hypertension, unspecified
0.000 0.671 0.328
E16.2 Hypoglycaemia, unspecified
0.000 0.672 0.328
I36.1 Nonrheumatic tricuspid (valve) insufficiency
0.000 0.673 0.327
I30.8 Other forms of acute pericarditis
0.001 0.676 0.323
I30.0 Acute nonspecific idiopathic pericarditis
0.001 0.676 0.323
E13.3 With ophthalmic complications
0.000 0.677 0.322
I15.1 Hypertension secondary to other renal disorders
0.000 0.678 0.321
I30.1 Infective pericarditis
0.001 0.681 0.318
E24.9 Cushing's syndrome, unspecified
0.000 0.682 0.318
I07 Rheumatic tricuspid valve diseases
0.000 0.697 0.303
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.698 0.302
I06 Rheumatic aortic valve diseases
0.000 0.705 0.295
E14.8 With unspecified complications
0.000 0.706 0.294
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.001 0.709 0.291
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.718 0.282
E44.1 Mild protein-energy malnutrition
0.000 0.720 0.279
E44.0 Moderate protein-energy malnutrition
0.000 0.720 0.279
I05 Rheumatic mitral valve diseases
0.000 0.721 0.279
I46 Cardiac arrest
0.000 0.724 0.275
I40.0 Infective myocarditis
0.001 0.734 0.265
E67 Other hyperalimentation
0.000 0.734 0.265
E68 Sequelae of hyperalimentation
0.000 0.734 0.265
I45.6 Preexcitation syndrome
0.000 0.737 0.263
I45.4 Nonspecific intraventricular block
0.000 0.739 0.261
I45.9 Conduction disorder, unspecified
0.000 0.742 0.258
I09 Other rheumatic heart diseases
0.000 0.743 0.257
I31.1 Chronic constrictive pericarditis
0.000 0.743 0.256
I31.0 Chronic adhesive pericarditis
0.000 0.747 0.253
I45.8 Other specified conduction disorders
0.000 0.750 0.250
I31.8 Other specified diseases of pericardium
0.000 0.755 0.245
I31.2 Haemopericardium, not elsewhere classified
0.000 0.755 0.245
I45.0 Right fascicular block
0.000 0.760 0.240
E13.9 Without complications
0.000 0.769 0.231
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.773 0.227
E46 Unspecified protein-energy malnutrition
0.001 0.779 0.220
E14.9 Without complications
0.000 0.782 0.218
I05.0 Mitral stenosis
0.000 0.782 0.218
I08 Multiple valve diseases
0.000 0.782 0.218
I07.9 Tricuspid valve disease, unspecified
0.000 0.783 0.217
I07.8 Other tricuspid valve diseases
0.000 0.783 0.217
I07.2 Tricuspid stenosis with insufficiency
0.000 0.783 0.217
I07.0 Tricuspid stenosis
0.000 0.783 0.217
E65 Localised adiposity
0.000 0.784 0.216
I07.1 Tricuspid insufficiency
0.000 0.786 0.214
I05.2 Mitral stenosis with insufficiency
0.000 0.787 0.213
I06.9 Rheumatic aortic valve disease, unspecified
0.000 0.788 0.212
I06.8 Other rheumatic aortic valve diseases
0.000 0.788 0.212
I06.2 Rheumatic aortic stenosis with insufficiency
0.000 0.788 0.212
I06.0 Rheumatic aortic stenosis
0.000 0.788 0.212
I45.5 Other specified heart block
0.000 0.789 0.211
I45.2 Bifascicular block
0.000 0.790 0.210
I95 Hypotension
0.000 0.792 0.208
E29.1 Testicular hypofunction
0.001 0.797 0.202
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.000 0.799 0.201
I78 Diseases of capillaries
0.000 0.799 0.201
I06.1 Rheumatic aortic insufficiency
0.000 0.799 0.200
I05.8 Other mitral valve diseases
0.000 0.800 0.200
I46.1 Sudden cardiac death, so described
0.000 0.802 0.198
I49.8 Other specified cardiac arrhythmias
0.001 0.807 0.193
I05.1 Rheumatic mitral insufficiency
0.000 0.807 0.193
I28 Other diseases of pulmonary vessels
0.001 0.809 0.190
E67.8 Other specified hyperalimentation
0.000 0.809 0.190
E67.3 Hypervitaminosis D
0.000 0.809 0.190
E67.2 Megavitamin-B6 syndrome
0.000 0.809 0.190
E67.1 Hypercarotenaemia
0.000 0.809 0.190
E67.0 Hypervitaminosis A
0.000 0.809 0.190
I12.9 Hypertensive renal disease without renal failure
0.000 0.813 0.187
I09.8 Other specified rheumatic heart diseases
0.000 0.816 0.184
I09.2 Chronic rheumatic pericarditis
0.000 0.816 0.184
I09.1 Rheumatic diseases of endocardium, valve unspecified
0.000 0.816 0.184
I09.0 Rheumatic myocarditis
0.000 0.816 0.184
I73 Other peripheral vascular diseases
0.000 0.821 0.179

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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