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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs76558737
log Bayes Factor = 11.0862
Chromosome 18   position 19,432,268  (GRCh37) Explore rs76558737 on Ensembl!
Variant rs76558737 is part of Cluster X0021

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XV Pregnancy, childbirth and the puerperium
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
O60-O75 Complications of labour and delivery
0.999 0.001 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.998 0.002 0.000
M05-M14 Inflammatory polyarthropathies
0.996 0.004 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.996 0.004 0.000
M20-M25 Other joint disorders
0.993 0.007 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.990 0.010 0.000
Chapter IX Diseases of the circulatory system
0.987 0.013 0.000
I30-I52 Other forms of heart disease
0.985 0.015 0.000
I51 Complications and ill-defined descriptions of heart disease
0.978 0.022 0.000
I34 Nonrheumatic mitral valve disorders
0.972 0.028 0.000
I51.7 Cardiomegaly
0.963 0.037 0.000
O36 Maternal care for other known or suspected foetal problems
0.960 0.040 0.000
E10-E14 Diabetes mellitus
0.956 0.044 0.000
M10 Gout
0.956 0.044 0.000
O70 Perineal laceration during delivery
0.955 0.045 0.000
Chapter VII Diseases of the eye and adnexa
0.955 0.045 0.000
O75 Other complications of labour and delivery, not elsewhere classified
0.954 0.046 0.000
O46 Antepartum haemorrhage, not elsewhere classified
0.953 0.047 0.000
I34.0 Mitral (valve) insufficiency
0.944 0.056 0.000
I42 Cardiomyopathy
0.941 0.059 0.000
M05 Seropositive rheumatoid arthritis
0.940 0.060 0.000
Chapter VI Diseases of the nervous system
0.939 0.061 0.000
E70-E90 Metabolic disorders
0.935 0.065 0.000
S00-S09 Injuries to the head
0.932 0.068 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.931 0.069 0.000
M10.9 Gout, unspecified
0.926 0.074 0.000
M23 Internal derangement of knee
0.925 0.075 0.000
O46.9 Antepartum haemorrhage, unspecified
0.923 0.077 0.000
H30-H36 Disorders of choroid and retina
0.921 0.079 0.000
M06 Other rheumatoid arthritis
0.915 0.085 0.000
M25 Other joint disorders, not elsewhere classified
0.908 0.092 0.000
E14 Unspecified diabetes mellitus
0.907 0.093 0.000
O70.1 Second degree perineal laceration during delivery
0.906 0.094 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.905 0.095 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.900 0.100 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.900 0.100 0.000
M24 Other specific joint derangements
0.894 0.106 0.000
I34.1 Mitral (valve) prolapse
0.881 0.119 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.877 0.123 0.000
M10.97 Gout, unspecified (Ankle and foot)
0.874 0.126 0.000
H33 Retinal detachments and breaks
0.874 0.126 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.872 0.128 0.000
E20-E35 Disorders of other endocrine glands
0.868 0.132 0.000
O75.6 Delayed delivery after spontaneous or unspecified rupture of membranes
0.868 0.132 0.000
O48 Prolonged pregnancy
0.867 0.133 0.000
O68 Labour and delivery complicated by foetal stress [distress]
0.858 0.142 0.000
I73 Other peripheral vascular diseases
0.856 0.144 0.000
M23.8 Other internal derangements of knee
0.853 0.147 0.000
H33.0 Retinal detachment with retinal break
0.852 0.148 0.000
M06.9 Rheumatoid arthritis, unspecified
0.850 0.150 0.000
O73 Retained placenta and membranes, without haemorrhage
0.850 0.150 0.000
S50-S59 Injuries to the elbow and forearm
0.849 0.151 0.000
M70-M79 Other soft tissue disorders
0.849 0.151 0.000
Chapter II Neoplasms
0.848 0.152 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.847 0.153 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.844 0.156 0.000
I05-I09 Chronic rheumatic heart diseases
0.844 0.156 0.000
Chapter XXII Codes for special purposes
0.843 0.157 0.000
E87.5 Hyperkalaemia
0.840 0.160 0.000
S40-S49 Injuries to the shoulder and upper arm
0.838 0.162 0.000
E14.9 Without complications
0.838 0.162 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.836 0.164 0.000
I51.8 Other ill-defined heart diseases
0.836 0.164 0.000
O36.0 Maternal care for rhesus isoimmunisation
0.836 0.164 0.000
E50-E64 Other nutritional deficiencies
0.836 0.164 0.000
E10 Insulin-dependent diabetes mellitus
0.833 0.167 0.000
M22 Disorders of patella
0.825 0.175 0.000
O00-O08 Pregnancy with abortive outcome
0.825 0.175 0.000
E83 Disorders of mineral metabolism
0.825 0.175 0.000
S02 Fracture of skull and facial bones
0.824 0.176 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.824 0.176 0.000
M25.5 Pain in joint
0.823 0.177 0.000
H10-H13 Disorders of conjunctiva
0.821 0.179 0.000
O36.8 Maternal care for other specified foetal problems
0.821 0.179 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.819 0.181 0.000
O36.9 Maternal care for foetal problem, unspecified
0.818 0.182 0.000
T79-T79 Certain early complications of trauma
0.818 0.182 0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.815 0.185 0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.814 0.186 0.000
M10.99 Gout, unspecified (Site unspecified)
0.810 0.190 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.809 0.191 0.000
O35 Maternal care for known or suspected foetal abnormality and damage
0.809 0.191 0.000
M33 Dermatopolymyositis
0.807 0.193 0.000
I42.9 Cardiomyopathy, unspecified
0.807 0.193 0.000
O75.8 Other specified complications of labour and delivery
0.806 0.194 0.000
G20-G26 Extrapyramidal and movement disorders
0.806 0.194 0.000
I42.1 Obstructive hypertrophic cardiomyopathy
0.805 0.195 0.000
Chapter VIII Diseases of the ear and mastoid process
0.803 0.197 0.000
O16 Unspecified maternal hypertension
0.802 0.198 0.000
O62 Abnormalities of forces of labour
0.801 0.199 0.000
E87.2 Acidosis
0.796 0.204 0.000
C34 Malignant neoplasm of bronchus and lung
0.796 0.204 0.000
M65-M68 Disorders of synovium and tendon
0.795 0.204 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.793 0.207 0.000
G70-G73 Diseases of myoneural junction and muscle
0.793 0.207 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.789 0.211 0.000
I42.2 Other hypertrophic cardiomyopathy
0.789 0.211 0.000
E83.5 Disorders of calcium metabolism
0.787 0.213 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.786 0.214 0.000
O42 Premature rupture of membranes
0.786 0.214 0.000
M23.81 Other internal derangements of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.786 0.214 0.000
M80-M85 Disorders of bone density and structure
0.785 0.215 0.000
C32 Malignant neoplasm of larynx
0.785 0.215 0.000
O64 Obstructed labour due to malposition and malpresentation of foetus
0.784 0.216 0.000
I73.0 Raynaud's syndrome
0.777 0.223 0.000
I71 Aortic aneurysm and dissection
0.775 0.225 0.000
E14.3 With ophthalmic complications
0.775 0.225 0.000
Chapter I Certain infectious and parasitic diseases
0.775 0.225 0.000
O72 Postpartum haemorrhage
0.774 0.226 0.000
M23.4 Loose body in knee
0.773 0.227 0.000
I45 Other conduction disorders
0.773 0.227 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.772 0.228 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.772 0.228 0.000
T00-T07 Injuries involving multiple body regions
0.770 0.230 0.000
M23.5 Chronic instability of knee
0.770 0.230 0.000
M34 Systemic sclerosis
0.769 0.231 0.000
O66 Other obstructed labour
0.769 0.231 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.767 0.233 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.766 0.234 0.000
S06 Intracranial injury
0.764 0.236 0.000
S10-S19 Injuries to the neck
0.764 0.236 0.000
O69 Labour and delivery complicated by umbilical cord complications
0.764 0.236 0.000
G90-G99 Other disorders of the nervous system
0.763 0.237 0.000
I74 Arterial embolism and thrombosis
0.763 0.237 0.000
M15-M19 Arthrosis
0.763 0.237 0.000
O75.7 Vaginal delivery following previous Caesarean section
0.760 0.240 0.000
M31 Other necrotising vasculopathies
0.759 0.241 0.000
O85-O92 Complications predominantly related to the puerperium
0.759 0.241 0.000
O68.2 Labour and delivery complicated by foetal heart rate anomaly with meconium in amniotic fluid
0.758 0.242 0.000
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified
0.756 0.244 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.756 0.244 0.000
S20-S29 Injuries to the thorax
0.753 0.247 0.000
I51.4 Myocarditis, unspecified
0.753 0.247 0.000
O36.6 Maternal care for excessive foetal growth
0.753 0.247 0.000
S02.2 Fracture of nasal bones
0.753 0.247 0.000
I33 Acute and subacute endocarditis
0.751 0.249 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.749 0.251 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.749 0.251 0.000
S70-S79 Injuries to the hip and thigh
0.749 0.251 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.747 0.253 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.744 0.256 0.000
G30-G32 Other degenerative diseases of the nervous system
0.743 0.257 0.000
M91-M94 Chondropathies
0.743 0.257 0.000
H36 Retinal disorders in diseases classified elsewhere
0.741 0.259 0.000
M25.7 Osteophyte
0.740 0.260 0.000
Chapter XI Diseases of the digestive system
0.740 0.260 0.000
S80-S89 Injuries to the knee and lower leg
0.739 0.261 0.000
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
0.738 0.262 0.000
S05 Injury of eye and orbit
0.736 0.264 0.000
M13 Other arthritis
0.735 0.265 0.000
O61 Failed induction of labour
0.735 0.265 0.000
I51.9 Heart disease, unspecified
0.735 0.265 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.735 0.265 0.000
E73 Lactose intolerance
0.735 0.265 0.000
O70.2 Third degree perineal laceration during delivery
0.734 0.265 0.000
K70-K77 Diseases of liver
0.734 0.266 0.000
T92 Sequelae of injuries of upper limb
0.734 0.266 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.732 0.268 0.000
M50-M54 Other dorsopathies
0.732 0.268 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.731 0.269 0.000
M21 Other acquired deformities of limbs
0.731 0.269 0.000
O70.0 First degree perineal laceration during delivery
0.730 0.270 0.000
M11 Other crystal arthropathies
0.730 0.270 0.000
I42.0 Dilated cardiomyopathy
0.727 0.273 0.000
O14 Gestational [pregnancy-induced] hypertension with significant proteinuria
0.727 0.273 0.000
I60-I69 Cerebrovascular diseases
0.727 0.273 0.000
Q60-Q64 Congenital malformations of the urinary system
0.724 0.276 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.720 0.280 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.719 0.281 0.000
M24.1 Other articular cartilage disorders
0.719 0.281 0.000
C32.0 Glottis
0.718 0.282 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
M60-M63 Disorders of muscles
0.717 0.283 0.000
O74 Complications of anaesthesia during labour and delivery
0.716 0.283 0.000
O71 Other obstetric trauma
0.716 0.283 0.000
O65 Obstructed labour due to maternal pelvic abnormality
0.716 0.283 0.000
O60 Preterm delivery
0.716 0.283 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.716 0.284 0.000
S01 Open wound of head
0.716 0.284 0.000
T33-T35 Frostbite
0.716 0.284 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.716 0.284 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.716 0.284 0.000
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.716 0.284 0.000
I08 Multiple valve diseases
0.715 0.285 0.000
M14 Arthropathies in other diseases classified elsewhere
0.714 0.286 0.000
M12 Other specific arthropathies
0.714 0.286 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.714 0.286 0.000
M08 Juvenile arthritis
0.714 0.286 0.000
H40-H42 Glaucoma
0.714 0.286 0.000
O45 Premature separation of placenta [abruptio placentae]
0.714 0.286 0.000
O44 Placenta praevia
0.714 0.286 0.000
O43 Placental disorders
0.714 0.286 0.000
O33 Maternal care for known or suspected disproportion
0.714 0.286 0.000
O31 Complications specific to multiple gestation
0.714 0.286 0.000
O40 Polyhydramnios
0.714 0.286 0.000
M19 Other arthrosis
0.714 0.286 0.000
O04 Medical abortion
0.713 0.287 0.000
C34.1 Upper lobe, bronchus or lung
0.713 0.287 0.000
M00-M03 Infectious arthropathies
0.713 0.287 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.712 0.288 0.000
M32 Systemic lupus erythematosus
0.712 0.288 0.000
M30 Polyarteritis nodosa and related conditions
0.712 0.288 0.000
M25.55 Pain in joint (Pelvic region and thigh)
0.711 0.289 0.000
E29 Testicular dysfunction
0.711 0.289 0.000
I36 Nonrheumatic tricuspid valve disorders
0.710 0.289 0.000
O73.1 Retained portions of placenta and membranes, without haemorrhage
0.710 0.290 0.000
E40-E46 Malnutrition
0.709 0.290 0.000
H11 Other disorders of conjunctiva
0.710 0.290 0.000
E53 Deficiency of other B group vitamins
0.709 0.291 0.000
M79.0 Rheumatism, unspecified
0.708 0.292 0.000
I00-I02 Acute rheumatic fever
0.708 0.292 0.000
E24 Cushing's syndrome
0.708 0.292 0.000
I35 Nonrheumatic aortic valve disorders
0.707 0.292 0.000
E10.9 Without complications
0.707 0.293 0.000
Chapter XIV Diseases of the genitourinary system
0.707 0.293 0.000
O30 Multiple gestation
0.706 0.294 0.000
I52 Other heart disorders in diseases classified elsewhere
0.706 0.294 0.000
I48 Atrial fibrillation and flutter
0.706 0.294 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.706 0.294 0.000
I41 Myocarditis in diseases classified elsewhere
0.706 0.294 0.000
I40 Acute myocarditis
0.706 0.294 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.706 0.294 0.000
I37 Pulmonary valve disorders
0.706 0.294 0.000
I32 Pericarditis in diseases classified elsewhere
0.706 0.294 0.000
I78 Diseases of capillaries
0.705 0.294 0.000
O10 Pre-existing hypertension complicating pregnancy, childbirth and the puerperium
0.705 0.295 0.000
G72 Other myopathies
0.705 0.295 0.000
T66-T78 Other and unspecified effects of external causes
0.704 0.296 0.000
H55-H59 Other disorders of eye and adnexa
0.704 0.296 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.703 0.297 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.702 0.298 0.000
K70 Alcoholic liver disease
0.702 0.298 0.000
S02.20 Fracture of nasal bones (closed)
0.702 0.298 0.000
I51.6 Cardiovascular disease, unspecified
0.701 0.299 0.000
I51.5 Myocardial degeneration
0.701 0.299 0.000
I51.3 Intracardiac thrombosis, not elsewhere classified
0.701 0.299 0.000
I51.2 Rupture of papillary muscle, not elsewhere classified
0.701 0.299 0.000
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.701 0.299 0.000
I51.0 Cardiac septal defect, acquired
0.701 0.299 0.000
K65-K67 Diseases of peritoneum
0.701 0.299 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.700 0.300 0.000
O70.9 Perineal laceration during delivery, unspecified
0.699 0.301 0.000
H90-H95 Other disorders of ear
0.697 0.303 0.000
I34.9 Nonrheumatic mitral valve disorder, unspecified
0.697 0.303 0.000
I34.8 Other nonrheumatic mitral valve disorders
0.697 0.303 0.000
I34.2 Nonrheumatic mitral (valve) stenosis
0.697 0.303 0.000
G57 Mononeuropathies of lower limb
0.697 0.303 0.000
T85.6 Mechanical complication of other specified internal prosthetic devices, implants and grafts
0.697 0.303 0.000
I72 Other aneurysm
0.696 0.303 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.696 0.304 0.000
M25.3 Other instability of joint
0.696 0.304 0.000
O75.2 Pyrexia during labour, not elsewhere classified
0.696 0.304 0.000
O63 Long labour
0.696 0.304 0.000
E11 Non-insulin-dependent diabetes mellitus
0.694 0.306 0.000
S80 Superficial injury of lower leg
0.694 0.306 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.694 0.306 0.000
H35 Other retinal disorders
0.693 0.307 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.693 0.307 0.000
S09 Other and unspecified injuries of head
0.693 0.307 0.000
T85.3 Mechanical complication of other ocular prosthetic devices, imnplants and grafts
0.693 0.307 0.000
I73.9 Peripheral vascular disease, unspecified
0.693 0.307 0.000
M10.96 Gout, unspecified (Lower leg)
0.692 0.308 0.000
H34 Retinal vascular occlusions
0.691 0.308 0.000
E87.1 Hypo-osmolality and hyponatraemia
0.691 0.309 0.000
T63 Toxic effect of contact with venomous animals
0.691 0.309 0.000
O36.7 Maternal care for viable foetus in abdominal pregnancy
0.688 0.312 0.000
O36.5 Maternal care for poor foetal growth
0.688 0.312 0.000
O36.4 Maternal care for intra-uterine death
0.688 0.312 0.000
O36.3 Maternal care for signs of foetal hypoxia
0.688 0.312 0.000
O36.2 Maternal care for hydrops foetalis
0.688 0.312 0.000
O36.1 Maternal care for other isoimmunisation
0.688 0.312 0.000
T79 Certain early complications of trauma, not elsewhere classified
0.688 0.312 0.000
M23.6 Other spontaneous disruption of ligament(s) of knee
0.686 0.314 0.000
E12 Malnutrition-related diabetes mellitus
0.685 0.314 0.000
M10.4 Other secondary gout
0.685 0.315 0.000
M10.3 Gout due to impairment of renal function
0.685 0.315 0.000
M10.2 Drug-induced gout
0.685 0.315 0.000
M10.1 Lead-induced gout
0.685 0.315 0.000
M10.0 Idiopathic gout
0.685 0.315 0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.685 0.315 0.000
O70.3 Fourth degree perineal laceration during delivery
0.685 0.315 0.000
I05 Rheumatic mitral valve diseases
0.684 0.315 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.684 0.315 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.684 0.316 0.000
O75.9 Complication of labour and delivery, unspecified
0.684 0.316 0.000
O75.5 Delayed delivery after artificial rupture of membranes
0.684 0.316 0.000
O75.4 Other complications of obstetric surgery and procedures
0.684 0.316 0.000
O75.3 Other infection during labour
0.684 0.316 0.000
O75.1 Shock during or following labour and delivery
0.684 0.316 0.000
O75.0 Maternal distress during labour and delivery
0.684 0.316 0.000
M24.41 Recurrent dislocation and subluxation of joint (Shoulder region)
0.684 0.316 0.000
M06.0 Seronegative rheumatoid arthritis
0.684 0.316 0.000
O46.8 Other antepartum haemorrhage
0.683 0.317 0.000
O46.0 Antepartum haemorrhage with coagulation defect
0.683 0.317 0.000
M24.2 Disorder of ligament
0.683 0.317 0.000
O41 Other disorders of amniotic fluid and membranes
0.682 0.318 0.000
S51 Open wound of forearm
0.681 0.319 0.000
H20 Iridocyclitis
0.679 0.321 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.679 0.321 0.000
M67 Other disorders of synovium and tendon
0.677 0.323 0.000
Q00-Q07 Congenital malformations of the nervous system
0.677 0.323 0.000
T98 Sequelae of other and unspecified effects of external causes
0.676 0.324 0.000
M79.6 Pain in limb
0.675 0.325 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.675 0.325 0.000
M22.8 Other disorders of patella
0.675 0.325 0.000
I42.8 Other cardiomyopathies
0.675 0.325 0.000
I42.7 Cardiomyopathy due to drugs and other external agents
0.675 0.325 0.000
I42.6 Alcoholic cardiomyopathy
0.675 0.325 0.000
I42.5 Other restrictive cardiomyopathy
0.675 0.325 0.000
I42.4 Endocardial fibroelastosis
0.675 0.325 0.000
I42.3 Endomyocardial (eosinophilic) disease
0.675 0.325 0.000
M05.8 Other seropositive rheumatoid arthritis
0.674 0.326 0.000
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.674 0.326 0.000
M05.2 Rheumatoid vasculitis
0.674 0.326 0.000
M05.1 Rheumatoid lung disease
0.674 0.326 0.000
M05.0 Felty's syndrome
0.674 0.326 0.000
O80-O84 Delivery
0.674 0.326 0.000
M86-M90 Other osteopathies
0.674 0.326 0.000
K66 Other disorders of peritoneum
0.673 0.327 0.000
M33.1 Other dermatomyositis
0.673 0.327 0.000
I30 Acute pericarditis
0.673 0.327 0.000
T51 Toxic effect of alcohol
0.671 0.329 0.000
T90 Sequelae of injuries of head
0.671 0.329 0.000
E85 Amyloidosis
0.670 0.330 0.000
E84 Cystic fibrosis
0.670 0.330 0.000
E79 Disorders of purine and pyrimidine metabolism
0.670 0.330 0.000
E77 Disorders of glycoprotein metabolism
0.670 0.330 0.000
E76 Disorders of glycosaminoglycan metabolism
0.670 0.330 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.670 0.330 0.000
E74 Other disorders of carbohydrate metabolism
0.670 0.330 0.000
E72 Other disorders of amino-acid metabolism
0.670 0.330 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.670 0.330 0.000
E70 Disorders of aromatic amino-acid metabolism
0.670 0.330 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.670 0.330 0.000
S52 Fracture of forearm
0.670 0.330 0.000
C34.9 Bronchus or lung, unspecified
0.670 0.330 0.000
S08 Traumatic amputation of part of head
0.668 0.332 0.000
S07 Crushing injury of head
0.668 0.332 0.000
S04 Injury of cranial nerves
0.668 0.332 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.668 0.332 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.667 0.332 0.000
H33.2 Serous retinal detachment
0.667 0.333 0.000
G25 Other extrapyramidal and movement disorders
0.667 0.333 0.000
T87 Complications peculiar to reattachment and amputation
0.667 0.333 0.000
I60 Subarachnoid haemorrhage
0.667 0.333 0.000
O73.0 Retained placenta, without haemorrhage
0.666 0.334 0.000
C32.9 Larynx, unspecified
0.666 0.334 0.000
K76 Other diseases of liver
0.666 0.334 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.665 0.335 0.000
M10.98 Gout, unspecified (Other)
0.664 0.336 0.000
M10.95 Gout, unspecified (Pelvic region and thigh)
0.664 0.336 0.000
M10.94 Gout, unspecified (Hand)
0.664 0.336 0.000
M10.93 Gout, unspecified (Forearm)
0.664 0.336 0.000
M10.92 Gout, unspecified (Upper arm)
0.664 0.336 0.000
M10.91 Gout, unspecified (Shoulder region)
0.664 0.336 0.000
M10.90 Gout, unspecified (Multiple sites)
0.664 0.336 0.000
M23.49 Loose body in knee-Unspec lig/men
0.664 0.336 0.000
M25.9 Joint disorder, unspecified
0.664 0.336 0.000
M19.9 Arthrosis, unspecified
0.664 0.336 0.000
M25.52 Pain in joint (Upper arm)
0.664 0.336 0.000
M23.9 Internal derangement of knee, unspecified
0.663 0.337 0.000
M23.1 Discoid meniscus (congenital)
0.663 0.337 0.000
M23.0 Cystic meniscus
0.663 0.337 0.000
M25.56 Pain in joint (Lower leg)
0.663 0.337 0.000
O35.9 Maternal care for (suspected) foetal abnormality and damage, unspecified
0.662 0.338 0.000
C15-C26 Malignant neoplasms of digestive organs
0.662 0.338 0.000
M79.7 Fibromyalgia
0.662 0.338 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.660 0.340 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.660 0.340 0.000
H31 Other disorders of choroid
0.660 0.340 0.000
H30 Chorioretinal inflammation
0.660 0.340 0.000
S42 Fracture of shoulder and upper arm
0.660 0.340 0.000
O99.0 Anaemia complicating pregnancy, childbirth and the puerperium
0.660 0.340 0.000
G57.6 Lesion of plantar nerve
0.659 0.341 0.000
O62.2 Other uterine inertia
0.659 0.341 0.000
T85.2 Mechanical complication of intraocular lens
0.659 0.341 0.000
O42.0 Premature rupture of membranes, onset of labour within 24 hours
0.659 0.341 0.000
M23.51 Chronic instability of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.659 0.341 0.000
E10.2 With renal complications
0.658 0.342 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.658 0.342 0.000
T85.8 Other complications of internal prosthetic devices, implants and grafts, not elsewhere classified
0.657 0.343 0.000
E13 Other specified diabetes mellitus
0.656 0.343 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.656 0.344 0.000
M06.8 Other specified rheumatoid arthritis
0.656 0.344 0.000
M06.4 Inflammatory polyarthropathy
0.656 0.344 0.000
M06.3 Rheumatoid nodule
0.656 0.344 0.000
M06.2 Rheumatoid bursitis
0.656 0.344 0.000
M06.1 Adult-onset Still's disease
0.656 0.344 0.000
M23.89 Other internal derangements of knee (Unspecified ligament or Unspecified meniscus)
0.655 0.345 0.000
K66.0 Peritoneal adhesions
0.654 0.346 0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs
0.654 0.346 0.000
O68.9 Labour and delivery complicated by foetal stress, unspecified
0.653 0.347 0.000
H46 Optic neuritis
0.652 0.348 0.000
M54 Dorsalgia
0.652 0.348 0.000
M07 Psoriatic and enteropathic arthropathies
0.652 0.348 0.000
M25.2 Flail joint
0.651 0.349 0.000
M25.1 Fistula of joint
0.651 0.349 0.000
M25.0 Haemarthrosis
0.651 0.349 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.651 0.349 0.000
S40 Superficial injury of shoulder and upper arm
0.650 0.349 0.000
M25.8 Other specified joint disorders
0.650 0.349 0.000
S02.9 Fracture of skull and facial bones, part unspecified
0.650 0.350 0.000
E14.8 With unspecified complications
0.650 0.350 0.000
E14.7 With multiple complications
0.650 0.350 0.000
E14.6 With other specified complications
0.650 0.350 0.000
E14.5 With peripheral circulatory complications
0.650 0.350 0.000
E14.4 With neurological complications
0.650 0.350 0.000
E14.2 Withrenal complications
0.650 0.350 0.000
E14.1 With ketoacidosis
0.650 0.350 0.000
E14.0 With coma
0.650 0.350 0.000
N20-N23 Urolithiasis
0.650 0.350 0.000
O00 Ectopic pregnancy
0.650 0.350 0.000
G20 Parkinson's disease
0.649 0.351 0.000
O34 Maternal care for known or suspected abnormality of pelvic organs
0.649 0.351 0.000
E87.4 Mixed disorder of acid-base balance
0.649 0.351 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.647 0.353 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.646 0.354 0.000
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.645 0.355 0.000
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.645 0.355 0.000
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.645 0.355 0.000
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.645 0.355 0.000
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.645 0.355 0.000
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.645 0.355 0.000
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.645 0.355 0.000
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.645 0.355 0.000
E80.4 Gilbert's syndrome
0.645 0.355 0.000
O15 Eclampsia
0.645 0.355 0.000
O12 Gestational [pregnancy-induced] oedema and proteinuria without hypertension
0.645 0.355 0.000
O11 Pre-existing hypertensive disorder with superimposed proteinuria
0.645 0.355 0.000
M25.57 Pain in joint (Ankle and foot)
0.645 0.355 0.000
E61 Deficiency of other nutrient elements
0.644 0.356 0.000
S50 Superficial injury of forearm
0.643 0.357 0.000
M35 Other systemic involvement of connective tissue
0.643 0.357 0.000
S80.9 Superficial injury of lower leg, unspecified
0.643 0.357 0.000
T93 Sequelae of injuries of lower limb
0.642 0.357 0.000
G72.9 Myopathy, unspecified
0.641 0.359 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.641 0.359 0.000
M24.9 Joint derangement, unspecified
0.641 0.359 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.641 0.359 0.000
M24.7 Protrusio acetabuli
0.641 0.359 0.000
M24.6 Ankylosis of joint
0.641 0.359 0.000
M24.5 Contracture of joint
0.641 0.359 0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified
0.641 0.359 0.000
M24.0 Loose body in joint
0.641 0.359 0.000
E10.3 With ophthalmic complications
0.641 0.359 0.000
E10.4 With neurological complications
0.640 0.359 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.640 0.359 0.000
G40-G47 Episodic and paroxysmal disorders
0.640 0.360 0.000
H92 Otalgia and effusion of ear
0.639 0.361 0.000
T91 Sequelae of injuries of neck and trunk
0.638 0.362 0.000
E87.7 Fluid overload
0.638 0.362 0.000
E87.3 Alkalosis
0.637 0.363 0.000
M25.59 Pain in joint (Site unspecified)
0.636 0.364 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.636 0.364 0.000
S41 Open wound of shoulder and upper arm
0.635 0.364 0.000
M22.3 Other derangements of patella
0.635 0.364 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.635 0.365 0.000
O68.0 Labour and delivery complicated by foetal heart rate anomaly
0.634 0.366 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.634 0.366 0.000
E87.0 Hyperosmolality and hypernatraemia
0.634 0.366 0.000
O04.9 Complete or unspecified, without complication
0.634 0.366 0.000
S90-S99 Injuries to the ankle and foot
0.633 0.367 0.000
N17-N19 Renal failure
0.633 0.367 0.000
E21.0 Primary hyperparathyroidism
0.631 0.369 0.000
O02 Other abnormal products of conception
0.631 0.369 0.000
M40-M43 Deforming dorsopathies
0.631 0.369 0.000
I45.9 Conduction disorder, unspecified
0.631 0.369 0.000
M72 Fibroblastic disorders
0.630 0.370 0.000
H21 Other disorders of iris and ciliary body
0.630 0.370 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.629 0.371 0.000
O64.0 Obstructed labour due to incomplete rotation of foetal head
0.629 0.371 0.000
M23.83 Other internal derangements of knee (Medial collateral ligament or Other and unspecified medial meniscus)
0.629 0.371 0.000
T95 Sequelae of burns, corrosions and frostbite
0.629 0.371 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.629 0.371 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.629 0.371 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.629 0.371 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.629 0.371 0.000
M19.99 Arthrosis, unspecified (Site unspecified)
0.628 0.372 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.628 0.372 0.000
O69.2 Labour and delivery complicated by other cord entanglement
0.628 0.372 0.000
M76 Enthesopathies of lower limb, excluding foot
0.627 0.373 0.000
H33.4 Traction detachment of retina
0.626 0.373 0.000
H33.1 Retinoschisis and retinal cysts
0.626 0.373 0.000
O42.9 Premature rupture of membranes, unspecified
0.625 0.375 0.000
M25.71 Osteophyte (Shoulder region)
0.625 0.375 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.625 0.375 0.000
Q80-Q89 Other congenital malformations
0.625 0.375 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.625 0.375 0.000
Q35-Q37 Cleft lip and cleft palate
0.625 0.375 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.625 0.375 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.625 0.375 0.000
M25.54 Pain in joint (Hand)
0.625 0.375 0.000
A30-A49 Other bacterial diseases
0.624 0.376 0.000
I60.9 Subarachnoid haemorrhage, unspecified
0.623 0.377 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.622 0.378 0.000
E34 Other endocrine disorders
0.622 0.378 0.000
E32 Diseases of thymus
0.622 0.378 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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