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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs76681713
log Bayes Factor = 24.4335
Chromosome 16   position 72,333,346  (GRCh37) Explore rs76681713 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status
1.000 0.000 0.000
Chapter XXI Factors influencing health status and contact with health services
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
I20-I25 Ischaemic heart diseases
1.000 0.000 0.000
Chapter XV Pregnancy, childbirth and the puerperium
1.000 0.000 0.000
Z00-Z13 Persons encountering health services for examination and investigation
0.999 0.001 0.000
Z80 Family history of malignant neoplasm
0.998 0.002 0.000
Z95 Presence of cardiac and vascular implants and grafts
0.997 0.003 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.992 0.008 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.991 0.009 0.000
Z12 Special screening examination for neoplasms
0.990 0.010 0.000
Z80.0 Family history of malignant neoplasm of digestive organs
0.989 0.011 0.000
S00-S09 Injuries to the head
0.988 0.012 0.000
Chapter XX External causes of morbidity and mortality
0.986 0.014 0.000
Chapter II Neoplasms
0.985 0.015 0.000
Z95.8 Presence of other cardiac and vascular implants and grafts
0.984 0.016 0.000
S60-S69 Injuries to the wrist and hand
0.982 0.018 0.000
I20 Angina pectoris
0.982 0.018 0.000
S80-S89 Injuries to the knee and lower leg
0.982 0.018 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.980 0.020 0.000
I24 Other acute ischaemic heart diseases
0.977 0.023 0.000
Z12.1 Special screening examination for neoplasm of intestinal tract
0.976 0.024 0.000
I25 Chronic ischaemic heart disease
0.969 0.031 0.000
Z04 Examination and observation for other reasons
0.968 0.032 0.000
S82 Fracture of lower leg, including ankle
0.966 0.034 0.000
O60-O75 Complications of labour and delivery
0.965 0.035 0.000
D50-D53 Nutritional anaemias
0.963 0.037 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.960 0.040 0.000
O00-O08 Pregnancy with abortive outcome
0.959 0.041 0.000
I71 Aortic aneurysm and dissection
0.959 0.041 0.000
S09 Other and unspecified injuries of head
0.957 0.043 0.000
Z80.4 Family history of malignant neoplasm of genital organs
0.954 0.046 0.000
S82.8 Fractures of other parts of lower leg
0.950 0.050 0.000
Z92 Personal history of medical treatment
0.949 0.051 0.000
Chapter X Diseases of the respiratory system
0.949 0.051 0.000
I25.2 Old myocardial infarction
0.944 0.056 0.000
S82.80 Fractures of other parts of lower leg (closed)
0.939 0.061 0.000
J95-J99 Other diseases of the respiratory system
0.937 0.063 0.000
I20.9 Angina pectoris, unspecified
0.936 0.064 0.000
Z92.2 Personal history of long-term (current) use of other medicaments
0.930 0.070 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.929 0.071 0.000
D51 Vitamin B12 deficiency anaemia
0.928 0.072 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.926 0.074 0.000
S61 Open wound of wrist and hand
0.926 0.074 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.925 0.075 0.000
Z40-Z54 Persons encountering health services for specific procedures and health care
0.925 0.075 0.000
S09.9 Unspecified injury of head
0.923 0.077 0.000
Z96 Presence of other functional implants
0.923 0.077 0.000
I20.8 Other forms of angina pectoris
0.920 0.080 0.000
Z02 Examination and encounter for administrative purposes
0.920 0.080 0.000
J98 Other respiratory disorders
0.919 0.081 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.919 0.081 0.000
S00 Superficial injury of head
0.918 0.082 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.917 0.083 0.000
I24.8 Other forms of acute ischaemic heart disease
0.912 0.088 0.000
M70-M79 Other soft tissue disorders
0.911 0.089 0.000
Z95.5 Presence of coronary angioplasty implant and graft
0.910 0.090 0.000
O48 Prolonged pregnancy
0.906 0.094 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.906 0.094 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.904 0.096 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.903 0.097 0.000
D10-D36 Benign neoplasms
0.902 0.098 0.000
C64-C68 Malignant neoplasms of urinary tract
0.899 0.101 0.000
Z95.1 Presence of aortocoronary bypass graft
0.897 0.103 0.000
I24.9 Acute ischaemic heart disease, unspecified
0.895 0.105 0.000
O02 Other abnormal products of conception
0.893 0.107 0.000
M79.8 Other specified soft tissue disorders
0.892 0.108 0.000
Z53 Persons encountering health services for specifie procedures, not carried out
0.887 0.113 0.000
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.886 0.114 0.000
Z04.3 Examination and observation following other accident
0.885 0.115 0.000
M79.86 Other specified soft tissue disorders (Lower leg)
0.884 0.116 0.000
J90-J94 Other diseases of pleura
0.883 0.117 0.000
Z96.1 Presence of intraocular lens
0.879 0.121 0.000
Z30-Z39 Persons encountering health services in circumstances related to reproduction
0.877 0.123 0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.875 0.125 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.874 0.126 0.000
O47 False labour
0.874 0.126 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.874 0.126 0.000
Z04.8 Examination and observation for other specified reasons
0.873 0.127 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.870 0.130 0.000
S62 Fracture at wrist and hand level
0.869 0.131 0.000
J98.1 Pulmonary collapse
0.868 0.132 0.000
Chapter V Mental and behavioural disorders
0.867 0.133 0.000
Z94 Transplanted organ and tissue status
0.864 0.136 0.000
Z02.8 Other examinations for administrative purposes
0.864 0.136 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.861 0.139 0.000
Z70-Z76 Persons encountering health services in other circumstances
0.860 0.140 0.000
C51-C58 Malignant neoplasms of female genital organs
0.854 0.146 0.000
I70 Atherosclerosis
0.852 0.148 0.000
Y83 Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.850 0.150 0.000
Z90 Acquired absence of organs, not elsewhere classified
0.849 0.151 0.000
M79.6 Pain in limb
0.849 0.151 0.000
Chapter VII Diseases of the eye and adnexa
0.848 0.152 0.000
Z53.0 Procedure not carried out because of contraindication
0.847 0.153 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.847 0.153 0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases
0.846 0.154 0.000
Z53.9 Procedure not carried out, unspecified reason
0.846 0.154 0.000
C67 Malignant neoplasm of bladder
0.846 0.154 0.000
S61.8 Open wound of other parts of wrist and hand
0.842 0.158 0.000
L20-L30 Dermatitis and eczema
0.835 0.165 0.000
I74 Arterial embolism and thrombosis
0.830 0.170 0.000
S00.8 Superficial injury of other parts of head
0.830 0.170 0.000
O73 Retained placenta and membranes, without haemorrhage
0.829 0.171 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.827 0.173 0.000
S89 Other and unspecified injuries of lower leg
0.827 0.173 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.827 0.173 0.000
S82.6 Fracture of lateral malleolus
0.826 0.174 0.000
I72 Other aneurysm
0.826 0.174 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.824 0.176 0.000
F30-F39 Mood [affective] disorders
0.824 0.176 0.000
Chapter VI Diseases of the nervous system
0.822 0.178 0.000
Y83.2 Surgical operation with anastomosis, bypass or graft
0.822 0.178 0.000
I22 Subsequent myocardial infarction
0.820 0.180 0.000
O36 Maternal care for other known or suspected foetal problems
0.819 0.181 0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.818 0.182 0.000
J98.4 Other disorders of lung
0.816 0.184 0.000
Z46 Fitting and adjustment of other devices
0.813 0.187 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.813 0.187 0.000
Chapter XXII Codes for special purposes
0.811 0.189 0.000
D70 Agranulocytosis
0.810 0.190 0.000
Z37 Outcome of delivery
0.810 0.190 0.000
O63 Long labour
0.809 0.191 0.000
Z80.7 Family history of malignant neoplasms of lymphoid, haematopoietic and related tissues
0.808 0.192 0.000
C67.9 Bladder, unspecified
0.807 0.193 0.000
Z83 Family history of other specific disorders
0.806 0.194 0.000
J90 Pleural effusion, not elsewhere classified
0.805 0.195 0.000
O47.1 False labour at or after 37 completed weeks of gestation
0.804 0.196 0.000
D50 Iron deficiency anaemia
0.804 0.196 0.000
S68 Traumatic amputation of wrist and hand
0.804 0.196 0.000
D35 Benign neoplasm of other and unspecified endocrine glands
0.803 0.197 0.000
Z95.4 Presence of other heart-valve replacement
0.802 0.198 0.000
Z47 Other orthopaedic follow-up care
0.802 0.198 0.000
L60-L75 Disorders of skin appendages
0.802 0.198 0.000
H30-H36 Disorders of choroid and retina
0.802 0.198 0.000
Y40 Systemic antibiotics
0.801 0.199 0.000
D68 Other coagulation defects
0.801 0.199 0.000
T93 Sequelae of injuries of lower limb
0.800 0.200 0.000
O75 Other complications of labour and delivery, not elsewhere classified
0.797 0.203 0.000
Z12.8 Special screening examination for neoplasm of other sites
0.796 0.204 0.000
S61.9 Open wound of wrist and hand, part unspecified
0.796 0.204 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.795 0.205 0.000
S50-S59 Injuries to the elbow and forearm
0.795 0.205 0.000
Z03 Medical observation and evaluation for suspected diseases and conditions
0.794 0.206 0.000
I21 Acute myocardial infarction
0.792 0.208 0.000
S82.2 Fracture of shaft of tibia
0.792 0.208 0.000
Z96.0 Presence of urogenital implants
0.790 0.210 0.000
O04 Medical abortion
0.790 0.210 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.790 0.210 0.000
Z97 Presence of other devices
0.789 0.211 0.000
T39.0 Salicylates
0.788 0.212 0.000
S64 Injury of nerves at wrist and hand level
0.788 0.212 0.000
D24 Benign neoplasm of breast
0.787 0.213 0.000
Z80.9 Family history of malignant neoplasm, unspecified
0.786 0.214 0.000
O02.0 Blighted ovum and nonhydatidiform mole
0.785 0.215 0.000
Z12.0 Special screening examination for neoplasm of stomach
0.784 0.216 0.000
Z11 Special screening examination for infectious and parasitic diseases
0.784 0.216 0.000
Chapter I Certain infectious and parasitic diseases
0.783 0.217 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.782 0.218 0.000
I25.1 Atherosclerotic heart disease
0.782 0.218 0.000
I05-I09 Chronic rheumatic heart diseases
0.781 0.219 0.000
O02.1 Missed abortion
0.781 0.219 0.000
O85-O92 Complications predominantly related to the puerperium
0.780 0.220 0.000
Z80.1 Family history of malignant neoplasm of trachea, bronchus and lung
0.780 0.220 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.779 0.221 0.000
D23 Other benign neoplasms of skin
0.779 0.221 0.000
O00 Ectopic pregnancy
0.779 0.221 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.778 0.222 0.000
O66 Other obstructed labour
0.778 0.222 0.000
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts
0.778 0.222 0.000
L29 Pruritus
0.777 0.223 0.000
C56 Malignant neoplasm of ovary
0.776 0.224 0.000
J09-J18 Influenza and pneumonia
0.775 0.225 0.000
O70 Perineal laceration during delivery
0.775 0.225 0.000
Z39 Postpartum care and examination
0.773 0.227 0.000
O20 Haemorrhage in early pregnancy
0.773 0.227 0.000
Z92.3 Personal history of irradiation
0.773 0.227 0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.773 0.227 0.000
Z90.6 Acquired absence of other parts of urinary tract
0.772 0.228 0.000
S09.8 Other specified injuries of head
0.770 0.230 0.000
Z98 Other postsurgical states
0.770 0.230 0.000
Z84 Family history of other conditions
0.770 0.230 0.000
S82.5 Fracture of medial malleolus
0.769 0.231 0.000
L50-L54 Urticaria and erythema
0.768 0.231 0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.768 0.232 0.000
I77 Other disorders of arteries and arterioles
0.768 0.232 0.000
D50.9 Iron deficiency anaemia, unspecified
0.768 0.232 0.000
M77 Other enthesopathies
0.767 0.233 0.000
J98.0 Diseases of bronchus, not elsewhere classified
0.766 0.234 0.000
O24 Diabetes mellitus in pregnancy
0.766 0.234 0.000
Z95.3 Presence of xenogenic heart valve
0.765 0.235 0.000
O23 Infections of genito-urinary tract in pregnancy
0.763 0.237 0.000
O69 Labour and delivery complicated by umbilical cord complications
0.761 0.239 0.000
S10-S19 Injuries to the neck
0.761 0.239 0.000
Z92.4 Personal history of major surgery, not elsewhere classified
0.760 0.240 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.760 0.240 0.000
Z90.1 Acquired absence of breast(s)
0.758 0.242 0.000
D80-D89 Certain disorders involving the immune mechanism
0.758 0.242 0.000
S70-S79 Injuries to the hip and thigh
0.757 0.243 0.000
I71.0 Dissection of aorta [any part]
0.757 0.243 0.000
Y43 Primarily systemic agents
0.757 0.243 0.000
S06 Intracranial injury
0.757 0.243 0.000
J95 Postprocedural respiratory disorders, not elsewhere classified
0.756 0.244 0.000
Z04.9 Examination and observation for unspecified reason
0.755 0.245 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.753 0.247 0.000
H35 Other retinal disorders
0.753 0.247 0.000
L72 Follicular cysts of skin and subcutaneous tissue
0.751 0.249 0.000
W00-W19 Falls
0.751 0.249 0.000
I21.4 Acute subendocardial myocardial infarction
0.749 0.251 0.000
Z37.0 Single live birth
0.749 0.251 0.000
Z82 Family history of certain disabilities and chronic diseases leading to disablement
0.749 0.251 0.000
Z81 Family history of mental and behavioural disorders
0.748 0.251 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.747 0.253 0.000
J99 Respiratory disorders in diseases classified elsewhere
0.747 0.253 0.000
Z90.5 Acquired absence of kidney
0.747 0.253 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.746 0.254 0.000
T39.1 4-Aminophenol derivatives
0.746 0.254 0.000
T42.4 Benzodiazepines
0.746 0.254 0.000
S61.7 Multiple open wounds of wrist and hand
0.745 0.254 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.745 0.255 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.744 0.256 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.741 0.259 0.000
C79 Secondary malignant neoplasm of other sites
0.740 0.260 0.000
I70.2 Atherosclerosis of arteries of the extremities
0.739 0.261 0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.738 0.262 0.000
F32 Depressive episode
0.738 0.262 0.000
S60 Superficial injury of wrist and hand
0.736 0.264 0.000
L29.9 Pruritus, unspecified
0.736 0.264 0.000
O43 Placental disorders
0.735 0.265 0.000
V80-V89 Other land transport accidents
0.733 0.267 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.733 0.267 0.000
Z01 Other special examinations and investigations of persons without complaint or reported diagnosis
0.732 0.268 0.000
X60-X84 Intentional self-harm
0.731 0.268 0.000
O73.0 Retained placenta, without haemorrhage
0.731 0.269 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.731 0.269 0.000
Z32 Pregnancy examination and test
0.731 0.269 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.731 0.269 0.000
T98 Sequelae of other and unspecified effects of external causes
0.731 0.269 0.000
D33 Benign neoplasm of brain and other parts of central nervous system
0.730 0.270 0.000
O30 Multiple gestation
0.730 0.270 0.000
Y57 Other and unspecified drugs and medicaments
0.730 0.270 0.000
Y52 Agents primarily affecting the cardiovascular system
0.728 0.272 0.000
Z48 Other surgical follow-up care
0.728 0.272 0.000
M79.62 Pain in limb (Upper arm)
0.727 0.273 0.000
S82.60 Fracture of lateral malleolus (closed)
0.726 0.274 0.000
F30 Manic episode
0.726 0.274 0.000
S40-S49 Injuries to the shoulder and upper arm
0.725 0.275 0.000
S90-S99 Injuries to the ankle and foot
0.725 0.275 0.000
Z47.0 Follow-up care involving removal of fracture plate and other internal fixation device
0.724 0.276 0.000
M79.2 Neuralgia and neuritis, unspecified
0.724 0.276 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.723 0.277 0.000
Z80.5 Family history of malignant neoplasm of urinary tract
0.722 0.277 0.000
H35.3 Degeneration of macula and posterior pole
0.722 0.278 0.000
Z00 General examination and investigation of persons without complaint or reported diagnosis
0.722 0.278 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.722 0.278 0.000
Z36 Antenatal screening
0.720 0.280 0.000
V20-V29 Motorcycle rider injured in transport accident
0.719 0.280 0.000
Z22 Carrier of infectious disease
0.719 0.281 0.000
D13 Benign neoplasm of other and ill-defined parts of digestive system
0.718 0.281 0.000
Z94.0 Kidney transplant status
0.717 0.283 0.000
M05-M14 Inflammatory polyarthropathies
0.717 0.283 0.000
Z89 Acquired absence of limb
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
I23 Certain current complications following acute myocardial infarction
0.717 0.283 0.000
M79.69 Pain in limb (Site unspecified)
0.717 0.283 0.000
Z10 Routine general health check-up of defined subpopulation
0.716 0.284 0.000
M40-M43 Deforming dorsopathies
0.716 0.284 0.000
S89.9 Unspecified injury of lower leg
0.716 0.284 0.000
Z80.6 Family history of leukaemia
0.716 0.284 0.000
Z80.2 Family history of malignant neoplasm of other respiratory and intrathoracic organs
0.716 0.284 0.000
Z74 Problems related to care-provider dependency
0.715 0.285 0.000
S62.3 Fracture of other metacarpal bone
0.715 0.285 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.714 0.286 0.000
Y83.8 Other surgical procedures
0.713 0.287 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.713 0.287 0.000
J93 Pneumothorax
0.713 0.287 0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.713 0.287 0.000
Y40.0 Penicillins
0.712 0.288 0.000
S02 Fracture of skull and facial bones
0.712 0.288 0.000
D55-D59 Haemolytic anaemias
0.711 0.289 0.000
S62.8 Fracture of other and unspecified parts of wrist and hand
0.711 0.289 0.000
T92 Sequelae of injuries of upper limb
0.710 0.289 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.710 0.290 0.000
Q80-Q89 Other congenital malformations
0.710 0.290 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.710 0.290 0.000
Z12.9 Special screening examination for neoplasm, unspecified
0.709 0.290 0.000
Z12.6 Special screening examination for neoplasm of bladder
0.709 0.290 0.000
Z12.5 Special screening examination for neoplasm of prostate
0.709 0.290 0.000
Z12.4 Special screening examination for neoplasm of cervix
0.709 0.290 0.000
Z12.3 Special screening examination for neoplasm of breast
0.709 0.290 0.000
Z12.2 Special screening examination for neoplasm of respiratory organs
0.709 0.290 0.000
T82.1 Mechanical complication of cardiac electronic device
0.709 0.291 0.000
S08 Traumatic amputation of part of head
0.709 0.291 0.000
S07 Crushing injury of head
0.709 0.291 0.000
S05 Injury of eye and orbit
0.709 0.291 0.000
S04 Injury of cranial nerves
0.709 0.291 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.709 0.291 0.000
I72.4 Aneurysm of artery of lower extremity
0.709 0.291 0.000
T87 Complications peculiar to reattachment and amputation
0.708 0.291 0.000
M79.66 Pain in limb (Lower leg)
0.708 0.292 0.000
D68.5 Primary Thrombophilia
0.708 0.292 0.000
Q60-Q64 Congenital malformations of the urinary system
0.707 0.293 0.000
I10-I15 Hypertensive diseases
0.707 0.293 0.000
Y35-Y36 Legal intervention and operations of war
0.707 0.293 0.000
Y10-Y34 Event of undetermined intent
0.707 0.293 0.000
Y00-Y09 Assault
0.707 0.293 0.000
X85-X99 Assault
0.707 0.293 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.707 0.293 0.000
X50-X57 Overexertion, travel and privation
0.707 0.293 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.707 0.293 0.000
X30-X39 Exposure to forces of nature
0.707 0.293 0.000
X20-X29 Contact with venomous animals and plants
0.707 0.293 0.000
X10-X19 Contact with heat and hot substances
0.707 0.293 0.000
X00-X09 Exposure to smoke, fire and flames
0.707 0.293 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.707 0.293 0.000
W75-W84 Other accidental threats to breathing
0.707 0.293 0.000
W65-W74 Accidental drowning and submersion
0.707 0.293 0.000
W50-W64 Exposure to animate mechanical forces
0.707 0.293 0.000
V98-V99 Other and unspecified transport accidents
0.707 0.293 0.000
V95-V97 Air and space transport accidents
0.707 0.293 0.000
V90-V94 Water transport accidents
0.707 0.293 0.000
V70-V79 Bus occupant injured in transport accident
0.707 0.293 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.707 0.293 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.707 0.293 0.000
V40-V49 Car occupant injured in transport accident
0.707 0.293 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.707 0.293 0.000
V01-V09 Pedestrian injured in transport accident
0.707 0.293 0.000
S61.1 Open wound of finger(s) with damage to nail
0.706 0.294 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.706 0.294 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.706 0.294 0.000
L03 Cellulitis
0.705 0.295 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.705 0.295 0.000
D36 Benign neoplasm of other and unspecified sites
0.704 0.296 0.000
S69 Other and unspecified injuries of wrist and hand
0.704 0.296 0.000
S67 Crushing injury of wrist and hand
0.704 0.296 0.000
S65 Injury of blood vessels at wrist and hand level
0.704 0.296 0.000
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level
0.704 0.296 0.000
I20.1 Angina pectoris with documented spasm
0.704 0.296 0.000
S62.4 Multiple fractures of metacarpal bones
0.704 0.296 0.000
S00.3 Superficial injury of nose
0.704 0.296 0.000
Z93 Artificial opening status
0.704 0.296 0.000
S88 Traumatic amputation of lower leg
0.704 0.296 0.000
S87 Crushing injury of lower leg
0.704 0.296 0.000
S86 Injury of muscle and tendon at lower leg level
0.704 0.296 0.000
S85 Injury of blood vessels at lower leg level
0.704 0.296 0.000
S84 Injury of nerves at lower leg level
0.704 0.296 0.000
S00.7 Multiple superficial injuries of head
0.703 0.297 0.000
J60-J70 Lung diseases due to external agents
0.703 0.297 0.000
C66 Malignant neoplasm of ureter
0.703 0.297 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.703 0.297 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.702 0.298 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.702 0.298 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.702 0.298 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.702 0.298 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.702 0.298 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.702 0.298 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.702 0.298 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.702 0.298 0.000
T36 Poisoning by systemic antibiotics
0.702 0.298 0.000
H33 Retinal detachments and breaks
0.702 0.298 0.000
S00.2 Other superficial injuries of eyelid and periocular area
0.702 0.298 0.000
Z91 Personal history of risk-factors, not elsewhere classified
0.701 0.299 0.000
I24.1 Dressler's syndrome
0.700 0.300 0.000
Z45 Adjustment and management of implanted device
0.700 0.300 0.000
T90 Sequelae of injuries of head
0.700 0.300 0.000
J94 Other pleural conditions
0.700 0.300 0.000
Z46.8 Fitting and adjustment of other specified devices
0.700 0.300 0.000
W20-W49 Exposure to inanimate mechanical forces
0.699 0.300 0.000
B25-B34 Other viral diseases
0.699 0.301 0.000
C34 Malignant neoplasm of bronchus and lung
0.699 0.301 0.000
D35.1 Parathyroid gland
0.699 0.301 0.000
V10-V19 Pedal cyclist injured in transport accident
0.698 0.302 0.000
O36.8 Maternal care for other specified foetal problems
0.696 0.304 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.695 0.304 0.000
Z08 Follow-up examination after treatment for malignant neoplasm
0.695 0.305 0.000
I25.6 Silent myocardial ischaemia
0.695 0.305 0.000
I25.4 Coronary artery aneurysm
0.695 0.305 0.000
I25.3 Aneurysm of heart
0.695 0.305 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.695 0.305 0.000
Z41 Procedures for purposes other than remedying health state
0.695 0.305 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.694 0.306 0.000
Z04.6 General psychiatric examination, requested by authority
0.694 0.306 0.000
Z04.5 Examination and observation following other inflicted injury
0.694 0.306 0.000
Z04.4 Examination and observation following alleged rape and seduction
0.694 0.306 0.000
Z04.2 Examination and observation following work accident
0.694 0.306 0.000
Z04.1 Examination and observation following transport accident
0.694 0.306 0.000
Z04.0 Blood-alcohol and blood-drug test
0.694 0.306 0.000
S81 Open wound of lower leg
0.694 0.306 0.000
S80 Superficial injury of lower leg
0.693 0.307 0.000
S82.9 Fracture of lower leg, part unspecified
0.693 0.307 0.000
S82.7 Multiple fractures of lower leg
0.693 0.307 0.000
D68.2 Hereditary deficiency of other clotting factors
0.693 0.307 0.000
Z96.7 Presence of other bone and tendon implants
0.693 0.307 0.000
F32.9 Depressive episode, unspecified
0.692 0.308 0.000
O74 Complications of anaesthesia during labour and delivery
0.692 0.308 0.000
O71 Other obstetric trauma
0.692 0.308 0.000
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified
0.692 0.308 0.000
O65 Obstructed labour due to maternal pelvic abnormality
0.692 0.308 0.000
O61 Failed induction of labour
0.692 0.308 0.000
O60 Preterm delivery
0.692 0.308 0.000
Z39.0 Care and examination immediately after delivery
0.691 0.309 0.000
O62 Abnormalities of forces of labour
0.691 0.309 0.000
D53 Other nutritional anaemias
0.691 0.309 0.000
D52 Folate deficiency anaemia
0.691 0.309 0.000
Chapter VIII Diseases of the ear and mastoid process
0.689 0.311 0.000
O45 Premature separation of placenta [abruptio placentae]
0.689 0.311 0.000
O44 Placenta praevia
0.689 0.311 0.000
O41 Other disorders of amniotic fluid and membranes
0.689 0.311 0.000
O35 Maternal care for known or suspected foetal abnormality and damage
0.689 0.311 0.000
O33 Maternal care for known or suspected disproportion
0.689 0.311 0.000
O31 Complications specific to multiple gestation
0.689 0.311 0.000
O40 Polyhydramnios
0.689 0.311 0.000
D14 Benign neoplasm of middle ear and respiratory system
0.688 0.312 0.000
O08 Complications following abortion and ectopic and molar pregnancy
0.688 0.312 0.000
O07 Failed attempted abortion
0.688 0.312 0.000
O06 Unspecified abortion
0.688 0.312 0.000
O05 Other abortion
0.688 0.312 0.000
O01 Hydatidiform mole
0.688 0.312 0.000
I71.8 Aortic aneurysm of unspecified site, ruptured
0.688 0.312 0.000
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.688 0.312 0.000
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.688 0.312 0.000
I71.3 Abdominal aortic aneurysm, ruptured
0.688 0.312 0.000
I71.1 Thoracic aortic aneurysm, ruptured
0.688 0.312 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.687 0.312 0.000
L72.1 Trichilemmal cyst
0.687 0.313 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.686 0.314 0.000
J91 Pleural effusion in conditions classified elsewhere
0.686 0.314 0.000
S09.7 Multiple injuries of head
0.686 0.314 0.000
S09.2 Traumatic rupture of ear drum
0.686 0.314 0.000
S09.1 Injury of muscle and tendon of head
0.686 0.314 0.000
S09.0 Injury of blood vessels of head, not elsewhere classified
0.686 0.314 0.000
O64 Obstructed labour due to malposition and malpresentation of foetus
0.684 0.315 0.000
D12 Benign neoplasm of colon, rectum, anus and anal canal
0.684 0.316 0.000
O21 Excessive vomiting in pregnancy
0.684 0.316 0.000
O72 Postpartum haemorrhage
0.682 0.318 0.000
S20-S29 Injuries to the thorax
0.682 0.318 0.000
S82.86 Maisonneuve's fracture
0.681 0.319 0.000
S82.81 Fractures of other parts of lower leg (open)
0.681 0.319 0.000
Z49 Care involving dialysis
0.681 0.319 0.000
Z92.9 Personal history of medical treatment, unspecified
0.680 0.320 0.000
Z92.8 Personal history of other medical treatment
0.680 0.320 0.000
Z92.5 Personal history of rehabilitation measures
0.680 0.320 0.000
Z92.0 Personal history of contraception
0.680 0.320 0.000
I25.9 Chronic ischaemic heart disease, unspecified
0.680 0.320 0.000
Y44 Agents primarily affecting blood constituents
0.679 0.321 0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.679 0.321 0.000
O03 Spontaneous abortion
0.677 0.323 0.000
M86-M90 Other osteopathies
0.677 0.323 0.000
T79-T79 Certain early complications of trauma
0.676 0.324 0.000
S68.1 Traumatic amputation of other single finger (complete)(partial)
0.676 0.324 0.000
M91-M94 Chondropathies
0.675 0.325 0.000
I25.8 Other forms of chronic ischaemic heart disease
0.674 0.326 0.000
Y83.0 Surgical operation with transplant of whole organ
0.673 0.327 0.000
T93.9 Sequelae of unspecified injury of lower limb
0.673 0.327 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.673 0.327 0.000
T86 Failure and rejection of transplanted organs and tissues
0.672 0.327 0.000
T43.2 Other and unspecified antidepressants
0.672 0.328 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.672 0.328 0.000
J96 Respiratory failure, not elsewhere classified
0.672 0.328 0.000
C43-C44 Melanoma and other malignant neoplasms of skin
0.672 0.328 0.000
L72.0 Epidermal cyst
0.672 0.328 0.000
Z97.5 Presence of (intra-uterine) contraceptive device
0.670 0.330 0.000
S51 Open wound of forearm
0.670 0.330 0.000
O63.0 Prolonged first stage (of labour)
0.669 0.331 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.669 0.331 0.000
O04.9 Complete or unspecified, without complication
0.669 0.331 0.000
D21 Other benign neoplasms of connective and other soft tissue
0.668 0.332 0.000
Z96.8 Presence of other specified functional implants
0.667 0.333 0.000
D60-D64 Aplastic and other anaemias
0.667 0.333 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.667 0.333 0.000
S82.20 Fracture of shaft of tibia (closed)
0.666 0.333 0.000
S00.1 Contusion of eyelid and periocular area
0.666 0.333 0.000
H10-H13 Disorders of conjunctiva
0.666 0.334 0.000
L10-L14 Bullous disorders
0.666 0.334 0.000
Z94.4 Liver transplant status
0.666 0.334 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.665 0.334 0.000
D51.8 Other vitamin B12 deficiency anaemias
0.665 0.335 0.000
D51.3 Other dietary vitamin B12 deficiency anaemia
0.665 0.335 0.000
D51.2 Transcobalamin II deficiency
0.665 0.335 0.000
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.665 0.335 0.000
Z94.8 Other transplanted organ and tissue status
0.665 0.335 0.000
Z03.3 Observation for suspected nervous system disorder
0.665 0.335 0.000
I25.5 Ischaemic cardiomyopathy
0.665 0.335 0.000
Z95.9 Presence of cardiac and vascular implant and graft, unspecified
0.665 0.335 0.000
I77.1 Stricture of artery
0.665 0.335 0.000
I60-I69 Cerebrovascular diseases
0.664 0.335 0.000
Y59 Other and unspecified vaccines and biological substances
0.664 0.336 0.000
Y58 Bacterial vaccines
0.664 0.336 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.664 0.336 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.664 0.336 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.664 0.336 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.664 0.336 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.664 0.336 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.664 0.336 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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