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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs76861960
log Bayes Factor = 13.3651
Chromosome 16   position 77,599,439  (GRCh37) Explore rs76861960 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
I50 Heart failure
1.000 0.000 0.000
Chapter X Diseases of the respiratory system
1.000 0.000 0.000
I30-I52 Other forms of heart disease
1.000 0.000 0.000
J30-J39 Other diseases of upper respiratory tract
1.000 0.000 0.000
J34 Other disorders of nose and nasal sinuses
0.999 0.001 0.000
I50.1 Left ventricular failure
0.999 0.001 0.000
Chapter VI Diseases of the nervous system
0.994 0.006 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.994 0.006 0.000
J34.2 Deviated nasal septum
0.989 0.011 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.988 0.012 0.000
I60-I69 Cerebrovascular diseases
0.988 0.012 0.000
Chapter XX External causes of morbidity and mortality
0.982 0.018 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.981 0.019 0.000
J34.3 Hypertrophy of nasal turbinates
0.979 0.021 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.978 0.022 0.000
I50.0 Congestive heart failure
0.978 0.022 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.978 0.022 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.977 0.023 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.973 0.027 0.000
Chapter I Certain infectious and parasitic diseases
0.966 0.034 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.962 0.038 0.000
E70-E90 Metabolic disorders
0.953 0.047 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.948 0.052 0.000
I67 Other cerebrovascular diseases
0.947 0.053 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.943 0.057 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.942 0.058 0.000
I51 Complications and ill-defined descriptions of heart disease
0.939 0.061 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.931 0.069 0.000
G55 Nerve root and plexus compressions in diseases classified elsewhere
0.929 0.071 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.929 0.071 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.928 0.072 0.000
G56 Mononeuropathies of upper limb
0.928 0.072 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.928 0.072 0.000
I50.9 Heart failure, unspecified
0.917 0.083 0.000
E20-E35 Disorders of other endocrine glands
0.909 0.091 0.000
I73 Other peripheral vascular diseases
0.906 0.094 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.903 0.097 0.000
J32 Chronic sinusitis
0.902 0.098 0.000
I77 Other disorders of arteries and arterioles
0.900 0.100 0.000
M86-M90 Other osteopathies
0.889 0.111 0.000
I69 Sequelae of cerebrovascular disease
0.889 0.111 0.000
R26 Abnormalities of gait and mobility
0.888 0.112 0.000
E87.2 Acidosis
0.888 0.112 0.000
O00-O08 Pregnancy with abortive outcome
0.877 0.123 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.876 0.124 0.000
J38 Diseases of vocal cords and larynx, not elsewhere classified
0.876 0.124 0.000
E87.5 Hyperkalaemia
0.874 0.126 0.000
Y42.5 Other oestrogens and progestogens
0.874 0.126 0.000
S90-S99 Injuries to the ankle and foot
0.871 0.129 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.869 0.131 0.000
M80-M85 Disorders of bone density and structure
0.865 0.135 0.000
A30-A49 Other bacterial diseases
0.864 0.136 0.000
M05-M14 Inflammatory polyarthropathies
0.856 0.144 0.000
M20-M25 Other joint disorders
0.855 0.145 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.855 0.145 0.000
I51.7 Cardiomegaly
0.854 0.146 0.000
R91 Abnormal findings on diagnostic imaging of lung
0.853 0.147 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.852 0.148 0.000
R93 Abnormal findings on diagnostic imaging of other body structures
0.849 0.151 0.000
I67.8 Other specified cerebrovascular diseases
0.847 0.153 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.847 0.153 0.000
T85.4 Mechanical complication of breast prosthesis and implant
0.843 0.157 0.000
I67.1 Cerebral aneurysm, nonruptured
0.843 0.157 0.000
I73.9 Peripheral vascular disease, unspecified
0.843 0.157 0.000
I46 Cardiac arrest
0.841 0.159 0.000
Chapter XI Diseases of the digestive system
0.839 0.161 0.000
G56.0 Carpal tunnel syndrome
0.835 0.165 0.000
T85.8 Other complications of internal prosthetic devices, implants and grafts, not elsewhere classified
0.834 0.166 0.000
T85.6 Mechanical complication of other specified internal prosthetic devices, implants and grafts
0.833 0.167 0.000
J32.0 Chronic maxillary sinusitis
0.832 0.168 0.000
J34.8 Other specified disorders of nose and nasal sinuses
0.829 0.171 0.000
M25 Other joint disorders, not elsewhere classified
0.829 0.171 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.829 0.171 0.000
R26.8 Other and unspecified abnormalities of gait and mobility
0.829 0.171 0.000
Chapter VIII Diseases of the ear and mastoid process
0.828 0.172 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.826 0.174 0.000
O02 Other abnormal products of conception
0.825 0.175 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.824 0.176 0.000
J80 Adult respiratory distress syndrome
0.824 0.176 0.000
G55.1 Nerve root and plexus compressions in intervertebral disk disorders
0.823 0.177 0.000
G90-G99 Other disorders of the nervous system
0.820 0.180 0.000
R29 Other symptoms and signs involving the nervous and musculoskeletal systems
0.819 0.181 0.000
I42 Cardiomyopathy
0.818 0.182 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.817 0.183 0.000
J38.3 Other diseases of vocal cords
0.817 0.183 0.000
J09-J18 Influenza and pneumonia
0.816 0.184 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.815 0.185 0.000
K00-K14 Diseases of oral cavity, salivary glands and jaws
0.815 0.185 0.000
S80-S89 Injuries to the knee and lower leg
0.813 0.187 0.000
Y42.7 Androgens and anabolic congeners
0.811 0.189 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.811 0.189 0.000
J00-J06 Acute upper respiratory infections
0.810 0.190 0.000
B95-B98 Bacterial, viral and other infectious agents
0.804 0.196 0.000
E87.7 Fluid overload
0.802 0.198 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.799 0.201 0.000
K70-K77 Diseases of liver
0.798 0.202 0.000
I64 Stroke, not specified as haemorrhage or infarction
0.797 0.203 0.000
M50-M54 Other dorsopathies
0.797 0.203 0.000
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction
0.796 0.204 0.000
B35-B49 Mycoses
0.795 0.205 0.000
S70-S79 Injuries to the hip and thigh
0.793 0.207 0.000
T82.1 Mechanical complication of cardiac electronic device
0.792 0.208 0.000
I36 Nonrheumatic tricuspid valve disorders
0.791 0.209 0.000
Y95 Nosocomial condition
0.788 0.212 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
0.788 0.212 0.000
W00-W19 Falls
0.788 0.212 0.000
O02.1 Missed abortion
0.788 0.212 0.000
K80-K87 Disorders of gallbladder, biliary tract and pancreas
0.786 0.214 0.000
E27 Other disorders of adrenal gland
0.785 0.215 0.000
G55.2 Nerve root and plexus compressions in spondylosis
0.782 0.218 0.000
J37 Chronic laryngitis and laryngotracheitis
0.782 0.218 0.000
M60-M63 Disorders of muscles
0.781 0.219 0.000
I61 Intracerebral haemorrhage
0.781 0.219 0.000
J30 Vasomotor and allergic rhinitis
0.781 0.219 0.000
G56.8 Other mononeuropathies of upper limb
0.781 0.219 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.780 0.220 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.779 0.221 0.000
I72 Other aneurysm
0.777 0.223 0.000
J32.8 Other chronic sinusitis
0.775 0.224 0.000
S10-S19 Injuries to the neck
0.774 0.226 0.000
G54 Nerve root and plexus disorders
0.774 0.226 0.000
K04 Diseases of pulp and periapical tissues
0.773 0.227 0.000
G58 Other mononeuropathies
0.773 0.227 0.000
G30-G32 Other degenerative diseases of the nervous system
0.773 0.227 0.000
A41 Other septicaemia
0.772 0.228 0.000
J31 Chronic rhinitis, nasopharyngitis and pharyngitis
0.771 0.229 0.000
I51.8 Other ill-defined heart diseases
0.771 0.229 0.000
J81 Pulmonary oedema
0.769 0.231 0.000
R26.3 Immobility
0.769 0.231 0.000
G50 Disorders of trigeminal nerve
0.767 0.233 0.000
O60-O75 Complications of labour and delivery
0.767 0.233 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.766 0.234 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.765 0.234 0.000
Chapter XXII Codes for special purposes
0.765 0.235 0.000
R27 Other lack of coordination
0.765 0.235 0.000
J95-J99 Other diseases of the respiratory system
0.763 0.236 0.000
E87.0 Hyperosmolality and hypernatraemia
0.762 0.237 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.762 0.238 0.000
B15-B19 Viral hepatitis
0.762 0.238 0.000
S40-S49 Injuries to the shoulder and upper arm
0.761 0.239 0.000
I67.2 Cerebral atherosclerosis
0.760 0.240 0.000
W20-W49 Exposure to inanimate mechanical forces
0.759 0.241 0.000
I77.1 Stricture of artery
0.759 0.241 0.000
G55.0 Nerve root and plexus compressions in neoplastic disease
0.759 0.241 0.000
M10 Gout
0.758 0.242 0.000
O80-O84 Delivery
0.758 0.242 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.754 0.246 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.754 0.246 0.000
T79-T79 Certain early complications of trauma
0.754 0.246 0.000
O85-O92 Complications predominantly related to the puerperium
0.753 0.247 0.000
O41 Other disorders of amniotic fluid and membranes
0.752 0.248 0.000
E28 Ovarian dysfunction
0.749 0.251 0.000
I77.8 Other specified disorders of arteries and arterioles
0.749 0.251 0.000
M25.4 Effusion of joint
0.748 0.252 0.000
A80-A89 Viral infections of the central nervous system
0.747 0.253 0.000
K02 Dental caries
0.746 0.254 0.000
O34 Maternal care for known or suspected abnormality of pelvic organs
0.746 0.254 0.000
R93.3 Abnormal findings on diagnostic imaging of other parts of digestive tract
0.746 0.254 0.000
Y52 Agents primarily affecting the cardiovascular system
0.746 0.254 0.000
M84 Disorders of continuity of bone
0.746 0.254 0.000
L97 Ulcer of lower limb, not elsewhere classified
0.746 0.254 0.000
R93.8 Abnormal findings on diagnostic imaging of other specified body structures
0.745 0.255 0.000
Y44 Agents primarily affecting blood constituents
0.745 0.255 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.743 0.257 0.000
I69.1 Sequelae of intracerebral haemorrhage
0.743 0.257 0.000
L89 Decubitus ulcer
0.742 0.258 0.000
M89 Other disorders of bone
0.741 0.259 0.000
M40-M43 Deforming dorsopathies
0.741 0.259 0.000
E83 Disorders of mineral metabolism
0.740 0.260 0.000
T86 Failure and rejection of transplanted organs and tissues
0.738 0.262 0.000
J86 Pyothorax
0.738 0.262 0.000
G56.2 Lesion of ulnar nerve
0.737 0.263 0.000
X20-X29 Contact with venomous animals and plants
0.737 0.263 0.000
E88 Other metabolic disorders
0.736 0.264 0.000
R90 Abnormal findings on diagnostic imaging of central nervous system
0.734 0.266 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.732 0.268 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.732 0.268 0.000
V10-V19 Pedal cyclist injured in transport accident
0.732 0.268 0.000
S60-S69 Injuries to the wrist and hand
0.731 0.269 0.000
S90 Superficial injury of ankle and foot
0.730 0.270 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.730 0.270 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.730 0.270 0.000
S00-S09 Injuries to the head
0.730 0.270 0.000
T82.5 Mechanical complication of other cardiac and vascular devices and implants
0.728 0.272 0.000
I77.0 Arteriovenous fistula, acquired
0.726 0.274 0.000
I51.9 Heart disease, unspecified
0.726 0.274 0.000
Y51.7 Beta-Adrenoreceptor antagonists, not elsewhere classified
0.725 0.275 0.000
R72 Abnormality of white blood cells, not elsewhere classified
0.725 0.275 0.000
M86 Osteomyelitis
0.723 0.277 0.000
I35 Nonrheumatic aortic valve disorders
0.721 0.279 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.718 0.281 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.718 0.282 0.000
S92 Fracture of foot, except ankle
0.718 0.282 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.718 0.282 0.000
K04.5 Chronic apical periodontitis
0.718 0.282 0.000
J84 Other interstitial pulmonary diseases
0.718 0.282 0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.718 0.282 0.000
M25.8 Other specified joint disorders
0.717 0.283 0.000
R29.8 Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
I52 Other heart disorders in diseases classified elsewhere
0.717 0.283 0.000
I48 Atrial fibrillation and flutter
0.717 0.283 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.717 0.283 0.000
I41 Myocarditis in diseases classified elsewhere
0.717 0.283 0.000
I40 Acute myocarditis
0.717 0.283 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.717 0.283 0.000
I37 Pulmonary valve disorders
0.717 0.283 0.000
I32 Pericarditis in diseases classified elsewhere
0.717 0.283 0.000
I30 Acute pericarditis
0.717 0.283 0.000
I33 Acute and subacute endocarditis
0.716 0.283 0.000
L50-L54 Urticaria and erythema
0.716 0.284 0.000
J34.1 Cyst and mucocele of nose and nasal sinus
0.716 0.284 0.000
J34.0 Abscess, furuncle and carbuncle of nose
0.716 0.284 0.000
I45 Other conduction disorders
0.716 0.284 0.000
M81 Osteoporosis without pathological fracture
0.716 0.284 0.000
I60 Subarachnoid haemorrhage
0.716 0.284 0.000
I77.6 Arteritis, unspecified
0.716 0.284 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.715 0.285 0.000
A41.5 Septicaemia due to other Gram-negative organisms
0.715 0.285 0.000
B25-B34 Other viral diseases
0.714 0.286 0.000
T85.3 Mechanical complication of other ocular prosthetic devices, imnplants and grafts
0.713 0.287 0.000
G70-G73 Diseases of myoneural junction and muscle
0.713 0.287 0.000
T33-T35 Frostbite
0.712 0.288 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.712 0.288 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.712 0.288 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.712 0.288 0.000
T00-T07 Injuries involving multiple body regions
0.712 0.288 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.711 0.289 0.000
S80 Superficial injury of lower leg
0.711 0.289 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.710 0.289 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.710 0.290 0.000
G20-G26 Extrapyramidal and movement disorders
0.710 0.290 0.000
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
0.709 0.290 0.000
M21 Other acquired deformities of limbs
0.709 0.291 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.709 0.291 0.000
K81 Cholecystitis
0.709 0.291 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.709 0.291 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.709 0.291 0.000
J60-J70 Lung diseases due to external agents
0.708 0.292 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.708 0.292 0.000
I70 Atherosclerosis
0.708 0.292 0.000
I46.9 Cardiac arrest, unspecified
0.707 0.293 0.000
G59 Mononeuropathy in diseases classified elsewhere
0.705 0.295 0.000
K86 Other diseases of pancreas
0.705 0.295 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.704 0.296 0.000
Y35-Y36 Legal intervention and operations of war
0.704 0.296 0.000
Y10-Y34 Event of undetermined intent
0.704 0.296 0.000
Y00-Y09 Assault
0.704 0.296 0.000
X85-X99 Assault
0.704 0.296 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.704 0.296 0.000
X50-X57 Overexertion, travel and privation
0.704 0.296 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.704 0.296 0.000
X30-X39 Exposure to forces of nature
0.704 0.296 0.000
X10-X19 Contact with heat and hot substances
0.704 0.296 0.000
X00-X09 Exposure to smoke, fire and flames
0.704 0.296 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.704 0.296 0.000
W75-W84 Other accidental threats to breathing
0.704 0.296 0.000
W65-W74 Accidental drowning and submersion
0.704 0.296 0.000
W50-W64 Exposure to animate mechanical forces
0.704 0.296 0.000
V98-V99 Other and unspecified transport accidents
0.704 0.296 0.000
V95-V97 Air and space transport accidents
0.704 0.296 0.000
V90-V94 Water transport accidents
0.704 0.296 0.000
V80-V89 Other land transport accidents
0.704 0.296 0.000
V70-V79 Bus occupant injured in transport accident
0.704 0.296 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.704 0.296 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.704 0.296 0.000
V40-V49 Car occupant injured in transport accident
0.704 0.296 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.704 0.296 0.000
V01-V09 Pedestrian injured in transport accident
0.704 0.296 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.704 0.296 0.000
M87 Osteonecrosis
0.704 0.296 0.000
I74 Arterial embolism and thrombosis
0.703 0.297 0.000
G53 Cranial nerve disorders in diseases classified elsewhere
0.703 0.297 0.000
G52 Disorders of other cranial nerves
0.703 0.297 0.000
T87 Complications peculiar to reattachment and amputation
0.701 0.299 0.000
M91-M94 Chondropathies
0.701 0.299 0.000
M00-M03 Infectious arthropathies
0.701 0.299 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.700 0.299 0.000
I73.0 Raynaud's syndrome
0.699 0.301 0.000
K12 Stomatitis and related lesions
0.698 0.302 0.000
O36 Maternal care for other known or suspected foetal problems
0.698 0.302 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.698 0.302 0.000
E40-E46 Malnutrition
0.697 0.302 0.000
K02.9 Dental caries, unspecified
0.697 0.303 0.000
J35 Chronic diseases of tonsils and adenoids
0.695 0.304 0.000
K70 Alcoholic liver disease
0.694 0.306 0.000
I78 Diseases of capillaries
0.693 0.307 0.000
T82.3 Mechanical complication of other vascular grafts
0.693 0.307 0.000
B99-B99 Other infectious diseases
0.692 0.308 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.692 0.308 0.000
B65-B83 Helminthiases
0.692 0.308 0.000
B50-B64 Protozoal diseases
0.692 0.308 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.692 0.308 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.692 0.308 0.000
A75-A79 Rickettsioses
0.692 0.308 0.000
A70-A74 Other diseases caused by chlamydiae
0.692 0.308 0.000
A65-A69 Other spirochaetal diseases
0.692 0.308 0.000
A20-A28 Certain zoonotic bacterial diseases
0.692 0.308 0.000
A15-A19 Tuberculosis
0.692 0.308 0.000
S50-S59 Injuries to the elbow and forearm
0.690 0.310 0.000
M50 Cervical disk disorders
0.690 0.310 0.000
M06 Other rheumatoid arthritis
0.690 0.310 0.000
R94 Abnormal results of function studies
0.690 0.310 0.000
Y59 Other and unspecified vaccines and biological substances
0.690 0.310 0.000
Y58 Bacterial vaccines
0.690 0.310 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.690 0.310 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.690 0.310 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.690 0.310 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.690 0.310 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.690 0.310 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.690 0.310 0.000
Y48 Anaesthetics and therapeutic gases
0.690 0.310 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.690 0.310 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.690 0.310 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.690 0.310 0.000
M25.46 Effusion of joint (Lower leg)
0.689 0.311 0.000
R93.5 Abnormal findings on diagnostic imaging of other abdominal regions, including retroperitoneum
0.689 0.311 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.689 0.311 0.000
B97 Viral agents as the cause of diseases classified to other chapters
0.689 0.311 0.000
R79 Other abnormal findings of blood chemistry
0.689 0.311 0.000
S20-S29 Injuries to the thorax
0.688 0.312 0.000
M10.9 Gout, unspecified
0.688 0.312 0.000
E23 Hypofunction and other disorders of pituitary gland
0.685 0.315 0.000
I63 Cerebral infarction
0.684 0.316 0.000
I62 Other nontraumatic intracranial haemorrhage
0.683 0.317 0.000
E85 Amyloidosis
0.683 0.317 0.000
E84 Cystic fibrosis
0.683 0.317 0.000
E79 Disorders of purine and pyrimidine metabolism
0.683 0.317 0.000
E77 Disorders of glycoprotein metabolism
0.683 0.317 0.000
E76 Disorders of glycosaminoglycan metabolism
0.683 0.317 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.683 0.317 0.000
E74 Other disorders of carbohydrate metabolism
0.683 0.317 0.000
E73 Lactose intolerance
0.683 0.317 0.000
E72 Other disorders of amino-acid metabolism
0.683 0.317 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.683 0.317 0.000
E70 Disorders of aromatic amino-acid metabolism
0.683 0.317 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.683 0.317 0.000
M90 Osteopathies in diseases classified elsewhere
0.680 0.320 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.680 0.320 0.000
I67.7 Cerebral arteritis, not elsewhere classified
0.679 0.321 0.000
I67.6 Nonpyogenic thrombosis of intracranial venous system
0.679 0.321 0.000
I67.5 Moyamoya disease
0.679 0.321 0.000
I67.4 Hypertensive encephalopathy
0.679 0.321 0.000
I67.3 Progressive vascular leukoencephalopathy
0.679 0.321 0.000
I67.0 Dissection of cerebral arteries, nonruptured
0.679 0.321 0.000
T83.5 Infection and inflammatory reaction due to prosthetic device, implant and graft in urinary system
0.678 0.322 0.000
E50-E64 Other nutritional deficiencies
0.678 0.322 0.000
K85 Acute pancreatitis
0.677 0.323 0.000
T85.9 Unspecified complication of internal prosthetic device, implant and graft
0.676 0.324 0.000
T85.2 Mechanical complication of intraocular lens
0.676 0.324 0.000
T85.1 Mechanical complication of implanted electronic stimulator of nervous system
0.676 0.324 0.000
T85.0 Mechanical complication of ventricular intracranial (communicating) shunt
0.676 0.324 0.000
L90 Atrophic disorders of skin
0.676 0.324 0.000
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.675 0.325 0.000
E87.4 Mixed disorder of acid-base balance
0.675 0.325 0.000
E87.3 Alkalosis
0.675 0.325 0.000
G55.3 Nerve root and plexus compressions in other dorsopathies
0.675 0.325 0.000
I51.6 Cardiovascular disease, unspecified
0.673 0.326 0.000
I51.5 Myocardial degeneration
0.673 0.326 0.000
I51.4 Myocarditis, unspecified
0.673 0.326 0.000
I51.3 Intracardiac thrombosis, not elsewhere classified
0.673 0.326 0.000
I51.2 Rupture of papillary muscle, not elsewhere classified
0.673 0.326 0.000
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.673 0.326 0.000
I51.0 Cardiac septal defect, acquired
0.673 0.326 0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems
0.673 0.327 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.673 0.327 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.673 0.327 0.000
O32 Maternal care for known or suspected malpresentation of foetus
0.671 0.329 0.000
A49 Bacterial infection of unspecified site
0.671 0.329 0.000
I05-I09 Chronic rheumatic heart diseases
0.670 0.330 0.000
O34.2 Maternal care due to uterine scar from previous surgery
0.668 0.332 0.000
B35 Dermatophytosis
0.667 0.333 0.000
G55.8 Nerve root and plexus compressions in other diseases classified elsewhere
0.666 0.334 0.000
J82 Pulmonary eosinophilia, not elsewhere classified
0.666 0.334 0.000
Y42.9 Other and unspecified hormone antagonists
0.665 0.335 0.000
Y42.8 Other and unspecified hormones and their synthetic substitutes
0.665 0.335 0.000
Y42.6 Antigonadotrophins, antioestrogens, antiandrogens, not elsewhere classified
0.665 0.335 0.000
Y42.4 Oral contraceptives
0.665 0.335 0.000
Y42.3 Insulin and oral hypoglycaemic [antidiabetic] drugs
0.665 0.335 0.000
Y42.2 Antithyroid drugs
0.665 0.335 0.000
Y42.1 Thyroid hormones and substitutes
0.665 0.335 0.000
Y42.0 Glucocorticoids and synthetic analogs
0.665 0.335 0.000
G56.9 Mononeuropathy of upper limb, unspecified
0.665 0.335 0.000
G56.4 Causalgia
0.665 0.335 0.000
G56.3 Lesion of radial nerve
0.665 0.335 0.000
G56.1 Other lesions of median nerve
0.665 0.335 0.000
R92 Abnormal findings on diagnostic imaging of breast
0.665 0.335 0.000
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts
0.664 0.336 0.000
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts
0.663 0.337 0.000
G90 Disorders of autonomic nervous system
0.662 0.338 0.000
R73 Elevated blood glucose level
0.662 0.338 0.000
H90-H95 Other disorders of ear
0.662 0.338 0.000
S72 Fracture of femur
0.662 0.338 0.000
V20-V29 Motorcycle rider injured in transport accident
0.661 0.338 0.000
M84.1 Nonunion of fracture [pseudarthrosis]
0.660 0.340 0.000
M24 Other specific joint derangements
0.660 0.340 0.000
I44 Atrioventricular and left bundle-branch block
0.659 0.341 0.000
G62 Other polyneuropathies
0.659 0.341 0.000
J86.9 Pyothorax without fistula
0.659 0.341 0.000
E83.4 Disorders of magnesium metabolism
0.659 0.341 0.000
G81 Hemiplegia
0.658 0.342 0.000
O75 Other complications of labour and delivery, not elsewhere classified
0.657 0.343 0.000
T66-T78 Other and unspecified effects of external causes
0.657 0.343 0.000
K81.1 Chronic cholecystitis
0.657 0.343 0.000
R93.7 Abnormal findings on diagnostic imaging of other parts of musculoskeletal system
0.656 0.343 0.000
I71 Aortic aneurysm and dissection
0.656 0.344 0.000
T83.0 Mechanical complication of urinary (indwelling) catheter
0.656 0.344 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.656 0.344 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.654 0.345 0.000
Y40 Systemic antibiotics
0.654 0.346 0.000
G93 Other disorders of brain
0.654 0.346 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.654 0.346 0.000
O82 Single delivery by Caesarean section
0.654 0.346 0.000
H80-H83 Diseases of inner ear
0.652 0.348 0.000
H65-H75 Diseases of middle ear and mastoid
0.652 0.348 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.652 0.348 0.000
E34 Other endocrine disorders
0.652 0.348 0.000
E32 Diseases of thymus
0.652 0.348 0.000
E31 Polyglandular dysfunction
0.652 0.348 0.000
E30 Disorders of puberty, not elsewhere classified
0.652 0.348 0.000
E29 Testicular dysfunction
0.652 0.348 0.000
E26 Hyperaldosteronism
0.652 0.348 0.000
E25 Adrenogenital disorders
0.652 0.348 0.000
E24 Cushing's syndrome
0.652 0.348 0.000
E22 Hyperfunction of pituitary gland
0.652 0.348 0.000
E20 Hypoparathyroidism
0.652 0.348 0.000
O41.0 Oligohydramnios
0.651 0.349 0.000
M07 Psoriatic and enteropathic arthropathies
0.650 0.350 0.000
M85 Other disorders of bone density and structure
0.650 0.350 0.000
X60-X84 Intentional self-harm
0.650 0.350 0.000
I67.9 Cerebrovascular disease, unspecified
0.650 0.350 0.000
I73.8 Other specified peripheral vascular diseases
0.649 0.350 0.000
I73.1 Thromboangiitis obliterans [Buerger]
0.649 0.350 0.000
Y57 Other and unspecified drugs and medicaments
0.649 0.351 0.000
J38.4 Oedema of larynx
0.649 0.351 0.000
K06 Other disorders of gingiva and edentulous alveolar ridge
0.649 0.351 0.000
I61.1 Intracerebral haemorrhage in hemisphere, cortical
0.647 0.352 0.000
T82.9 Unspecified complication of cardiac and vascular prosthetic device, implant and graft
0.647 0.353 0.000
T82.6 Infection and inflammatory reaction due to cardiac valve prosthesis
0.647 0.353 0.000
T82.4 Mechanical complication of vascular dialysis catheter
0.647 0.353 0.000
T82.2 Mechanical complication of coronary artery bypass and valve grafts
0.647 0.353 0.000
T82.0 Mechanical complication of heart valve prosthesis
0.647 0.353 0.000
J32.4 Chronic pansinusitis
0.647 0.353 0.000
J32.3 Chronic sphenoidal sinusitis
0.647 0.353 0.000
J32.2 Chronic ethmoidal sinusitis
0.647 0.353 0.000
J32.1 Chronic frontal sinusitis
0.647 0.353 0.000
R25 Abnormal involuntary movements
0.646 0.354 0.000
E89.3 Postprocedural hypopituitarism
0.646 0.354 0.000
I77.5 Necrosis of artery
0.646 0.354 0.000
I77.4 Coeliac artery compression syndrome
0.646 0.354 0.000
I77.3 Arterial fibromuscular dysplasia
0.646 0.354 0.000
I77.2 Rupture of artery
0.646 0.354 0.000
R27.0 Ataxia, unspecified
0.645 0.355 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.645 0.355 0.000
L40-L45 Papulosquamous disorders
0.645 0.355 0.000
L89.1 Stage II decubitus ulcer
0.644 0.356 0.000
J30.1 Allergic rhinitis due to pollen
0.643 0.357 0.000
M22 Disorders of patella
0.642 0.358 0.000
J38.2 Nodules of vocal cords
0.641 0.358 0.000
I42.0 Dilated cardiomyopathy
0.641 0.359 0.000
G61 Inflammatory polyneuropathy
0.641 0.359 0.000
I36.1 Nonrheumatic tricuspid (valve) insufficiency
0.641 0.359 0.000
M62 Other disorders of muscle
0.640 0.359 0.000
J36 Peritonsillar abscess
0.639 0.360 0.000
B96 Other bacterial agents as the cause of diseases classified to other chapters
0.639 0.361 0.000
K76 Other diseases of liver
0.638 0.362 0.000
I46.0 Cardiac arrest with successful resuscitation
0.638 0.362 0.000
J15 Bacterial pneumonia, not elsewhere classified
0.638 0.362 0.000
M25.86 Other specified joint disorders (Lower leg)
0.637 0.363 0.000
I69.8 Sequelae of other and unspecified cerebrovascular diseases
0.637 0.363 0.000
I69.2 Sequelae of other nontraumatic intracranial haemorrhage
0.637 0.363 0.000
I69.0 Sequelae of subarachnoid haemorrhage
0.637 0.363 0.000
R29.6 Tendency to fall, not elsewhere classified
0.637 0.363 0.000
J03 Acute tonsillitis
0.637 0.363 0.000
R26.1 Paralytic gait
0.637 0.363 0.000
R26.0 Ataxic gait
0.637 0.363 0.000
T80.2 Infections following infusion, transfusion and therapeutic injection
0.636 0.364 0.000
K74 Fibrosis and cirrhosis of liver
0.636 0.364 0.000
M25.0 Haemarthrosis
0.636 0.364 0.000
K75 Other inflammatory liver diseases
0.636 0.364 0.000
O26 Maternal care for other conditions predominantly related to pregnancy
0.635 0.364 0.000
G95 Other diseases of spinal cord
0.635 0.365 0.000
K12.3 Oral mucositis (ulcerative)
0.635 0.365 0.000
Y43 Primarily systemic agents
0.635 0.365 0.000
E65-E68 Obesity and other hyperalimentation
0.635 0.365 0.000
S09 Other and unspecified injuries of head
0.635 0.365 0.000
J02 Acute pharyngitis
0.635 0.365 0.000
E28.2 Polycystic ovarian syndrome
0.635 0.365 0.000
W19 Unspecified fall
0.634 0.366 0.000
I72.4 Aneurysm of artery of lower extremity
0.633 0.367 0.000
E27.1 Primary adrenocortical insufficiency
0.633 0.367 0.000
M51 Other intervertebral disk disorders
0.632 0.368 0.000
L89.0 Stage I decubitus ulcer and pressure area
0.631 0.369 0.000
E87.6 Hypokalaemia
0.630 0.370 0.000
O72 Postpartum haemorrhage
0.630 0.370 0.000
G60 Hereditary and idiopathic neuropathy
0.630 0.370 0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis
0.630 0.370 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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