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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs77237430
log Bayes Factor = 10.8581
Chromosome 8   position 117,500,622  (GRCh37) Explore rs77237430 on Ensembl!
Variant rs77237430 is part of Cluster X0021

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter VII Diseases of the eye and adnexa
1.000 0.000 0.000
J30-J39 Other diseases of upper respiratory tract
0.999 0.001 0.000
Chapter X Diseases of the respiratory system
0.999 0.001 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.998 0.002 0.000
M70-M79 Other soft tissue disorders
0.997 0.003 0.000
J38 Diseases of vocal cords and larynx, not elsewhere classified
0.997 0.003 0.000
Chapter IX Diseases of the circulatory system
0.995 0.005 0.000
O00-O08 Pregnancy with abortive outcome
0.994 0.006 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.994 0.006 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.992 0.008 0.000
I77 Other disorders of arteries and arterioles
0.985 0.015 0.000
M50-M54 Other dorsopathies
0.985 0.015 0.000
M79.6 Pain in limb
0.982 0.018 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.979 0.021 0.000
M05-M14 Inflammatory polyarthropathies
0.974 0.026 0.000
O03 Spontaneous abortion
0.973 0.027 0.000
M54 Dorsalgia
0.970 0.030 0.000
J32 Chronic sinusitis
0.969 0.031 0.000
I77.1 Stricture of artery
0.964 0.036 0.000
M40-M43 Deforming dorsopathies
0.963 0.037 0.000
J38.3 Other diseases of vocal cords
0.961 0.039 0.000
O02 Other abnormal products of conception
0.961 0.039 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.958 0.042 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.952 0.048 0.000
O03.4 Incomplete, without complication
0.950 0.050 0.000
M54.5 Low back pain
0.942 0.058 0.000
Chapter VI Diseases of the nervous system
0.940 0.060 0.000
O02.1 Missed abortion
0.938 0.062 0.000
H53-H54 Visual disturbances and blindness
0.931 0.069 0.000
M54.59 Low back pain (Site unspecified)
0.929 0.071 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.929 0.071 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.925 0.075 0.000
M80-M85 Disorders of bone density and structure
0.925 0.075 0.000
J32.9 Chronic sinusitis, unspecified
0.923 0.077 0.000
J38.1 Polyp of vocal cord and larynx
0.922 0.078 0.000
S80-S89 Injuries to the knee and lower leg
0.917 0.083 0.000
J34 Other disorders of nose and nasal sinuses
0.915 0.085 0.000
I10-I15 Hypertensive diseases
0.913 0.087 0.000
H55-H59 Other disorders of eye and adnexa
0.905 0.095 0.000
J00-J06 Acute upper respiratory infections
0.904 0.096 0.000
M06 Other rheumatoid arthritis
0.901 0.099 0.000
M79.7 Fibromyalgia
0.899 0.101 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.899 0.101 0.000
I71 Aortic aneurysm and dissection
0.897 0.103 0.000
M43 Other deforming dorsopathies
0.897 0.103 0.000
M79.66 Pain in limb (Lower leg)
0.894 0.106 0.000
J33 Nasal polyp
0.890 0.110 0.000
I12 Hypertensive renal disease
0.888 0.112 0.000
Chapter V Mental and behavioural disorders
0.888 0.112 0.000
I30-I52 Other forms of heart disease
0.880 0.120 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.879 0.120 0.000
H04 Disorders of lachrymal system
0.876 0.124 0.000
J34.2 Deviated nasal septum
0.875 0.125 0.000
H52 Disorders of refraction and accommodation
0.874 0.126 0.000
M79.63 Pain in limb (Forearm)
0.873 0.127 0.000
F30-F39 Mood [affective] disorders
0.872 0.128 0.000
M65-M68 Disorders of synovium and tendon
0.871 0.129 0.000
J38.0 Paralysis of vocal cords and larynx
0.871 0.129 0.000
I51 Complications and ill-defined descriptions of heart disease
0.868 0.132 0.000
H54 Blindness and low vision
0.865 0.135 0.000
I49 Other cardiac arrhythmias
0.862 0.138 0.000
I12.0 Hypertensive renal disease with renal failure
0.862 0.138 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.862 0.138 0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.862 0.138 0.000
M11 Other crystal arthropathies
0.861 0.139 0.000
J38.7 Other diseases of larynx
0.856 0.144 0.000
M41 Scoliosis
0.854 0.146 0.000
I77.9 Disorder of arteries and arterioles, unspecified
0.851 0.149 0.000
I77.6 Arteritis, unspecified
0.851 0.149 0.000
M79.60 Pain in limb (Multiple sites)
0.851 0.149 0.000
I51.9 Heart disease, unspecified
0.846 0.154 0.000
H43-H45 Disorders of vitreous body and globe
0.843 0.157 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.841 0.159 0.000
M54.3 Sciatica
0.836 0.164 0.000
H20 Iridocyclitis
0.833 0.167 0.000
S82 Fracture of lower leg, including ankle
0.833 0.167 0.000
M10 Gout
0.829 0.171 0.000
M71 Other bursopathies
0.829 0.171 0.000
F31 Bipolar affective disorder
0.828 0.172 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.827 0.173 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.826 0.174 0.000
I73 Other peripheral vascular diseases
0.822 0.178 0.000
H04.2 Epiphora
0.819 0.181 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.818 0.182 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.817 0.183 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.815 0.185 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.815 0.185 0.000
M43.1 Spondylolisthesis
0.814 0.186 0.000
T93 Sequelae of injuries of lower limb
0.814 0.186 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.814 0.186 0.000
J30 Vasomotor and allergic rhinitis
0.811 0.189 0.000
M51 Other intervertebral disk disorders
0.811 0.189 0.000
J33.8 Other polyp of sinus
0.810 0.190 0.000
S10-S19 Injuries to the neck
0.809 0.191 0.000
M53 Other dorsopathies, not elsewhere classified
0.809 0.191 0.000
H50 Other strabismus
0.806 0.194 0.000
M79.79 Fibromyalgia (Site unspecified)
0.805 0.195 0.000
J09-J18 Influenza and pneumonia
0.805 0.195 0.000
M45-M49 Spondylopathies
0.805 0.195 0.000
J38.4 Oedema of larynx
0.804 0.196 0.000
T92 Sequelae of injuries of upper limb
0.803 0.197 0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee
0.800 0.200 0.000
M84 Disorders of continuity of bone
0.800 0.200 0.000
G40-G47 Episodic and paroxysmal disorders
0.799 0.201 0.000
I05-I09 Chronic rheumatic heart diseases
0.798 0.202 0.000
S40-S49 Injuries to the shoulder and upper arm
0.798 0.202 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.797 0.202 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.797 0.203 0.000
M86-M90 Other osteopathies
0.797 0.203 0.000
M79.8 Other specified soft tissue disorders
0.796 0.204 0.000
H18 Other disorders of cornea
0.796 0.204 0.000
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
0.795 0.205 0.000
J03 Acute tonsillitis
0.794 0.206 0.000
O03.9 Complete or unspecified, without complication
0.793 0.207 0.000
H52.2 Astigmatism
0.789 0.211 0.000
H49 Paralytic strabismus
0.788 0.212 0.000
M79.69 Pain in limb (Site unspecified)
0.786 0.214 0.000
F32 Depressive episode
0.785 0.215 0.000
M06.9 Rheumatoid arthritis, unspecified
0.785 0.215 0.000
H10-H13 Disorders of conjunctiva
0.780 0.220 0.000
M11.2 Other chondrocalcinosis
0.779 0.221 0.000
M54.6 Pain in thoracic spine
0.779 0.221 0.000
H54.7 Unspecified visual loss
0.778 0.221 0.000
F31.9 Bipolar affective disorder, unspecified
0.778 0.222 0.000
M65 Synovitis and tenosynovitis
0.778 0.222 0.000
M06.0 Seronegative rheumatoid arthritis
0.778 0.222 0.000
M79.65 Pain in limb (Pelvic region and thigh)
0.776 0.224 0.000
M41.9 Scoliosis, unspecified
0.776 0.224 0.000
M79.0 Rheumatism, unspecified
0.773 0.227 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.772 0.228 0.000
I73.9 Peripheral vascular disease, unspecified
0.772 0.228 0.000
F32.9 Depressive episode, unspecified
0.771 0.229 0.000
J32.8 Other chronic sinusitis
0.767 0.233 0.000
M91-M94 Chondropathies
0.767 0.233 0.000
J32.2 Chronic ethmoidal sinusitis
0.767 0.233 0.000
M79.62 Pain in limb (Upper arm)
0.766 0.234 0.000
M85 Other disorders of bone density and structure
0.765 0.235 0.000
G44 Other headache syndromes
0.762 0.238 0.000
H57 Other disorders of eye and adnexa
0.760 0.240 0.000
S82.3 Fracture of lower end of tibia
0.759 0.241 0.000
H43 Disorders of vitreous body
0.758 0.242 0.000
I70 Atherosclerosis
0.755 0.245 0.000
I49.9 Cardiac arrhythmia, unspecified
0.754 0.246 0.000
H58 Other disorders of eye and adnexa in diseases classified elsewhere
0.754 0.246 0.000
M43.0 Spondylolysis
0.753 0.246 0.000
O00 Ectopic pregnancy
0.752 0.248 0.000
M79.4 Hypertrophy of (infrapatellar) fat pad
0.752 0.248 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.752 0.248 0.000
M54.50 Low back pain (Multiple sites in spine)
0.752 0.248 0.000
M60-M63 Disorders of muscles
0.747 0.253 0.000
M54.55 Low back pain (Thoracolumbar region)
0.745 0.255 0.000
M79.67 Pain in limb (Ankle and foot)
0.745 0.255 0.000
O20 Haemorrhage in early pregnancy
0.744 0.256 0.000
H20.9 Iridocyclitis, unspecified
0.743 0.257 0.000
M76 Enthesopathies of lower limb, excluding foot
0.742 0.258 0.000
I51.7 Cardiomegaly
0.742 0.258 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.741 0.259 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.739 0.261 0.000
M15-M19 Arthrosis
0.739 0.261 0.000
I49.3 Ventricular premature depolarisation
0.736 0.264 0.000
H53 Visual disturbances
0.736 0.264 0.000
M05 Seropositive rheumatoid arthritis
0.734 0.266 0.000
H04.1 Other disorders of lachrymal gland
0.733 0.267 0.000
J32.4 Chronic pansinusitis
0.732 0.268 0.000
H59 Postprocedural disorders of eye and adnexa, not elsewhere classified
0.731 0.269 0.000
M54.2 Cervicalgia
0.731 0.269 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.730 0.270 0.000
T90 Sequelae of injuries of head
0.730 0.270 0.000
I49.5 Sick sinus syndrome
0.729 0.271 0.000
M79.1 Myalgia
0.728 0.272 0.000
M77 Other enthesopathies
0.725 0.275 0.000
I49.8 Other specified cardiac arrhythmias
0.725 0.275 0.000
M10.9 Gout, unspecified
0.725 0.275 0.000
G70-G73 Diseases of myoneural junction and muscle
0.724 0.276 0.000
M43.16 Spondylolisthesis (Lumbar region)
0.723 0.277 0.000
M81 Osteoporosis without pathological fracture
0.723 0.277 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.722 0.278 0.000
G37 Other demyelinating diseases of central nervous system
0.722 0.278 0.000
M11.26 Other chondrocalcinosis (Lower leg)
0.721 0.279 0.000
M79.2 Neuralgia and neuritis, unspecified
0.719 0.281 0.000
M72 Fibroblastic disorders
0.719 0.281 0.000
F80-F89 Disorders of psychological development
0.719 0.281 0.000
I11 Hypertensive heart disease
0.719 0.281 0.000
Q24 Other congenital malformations of heart
0.718 0.282 0.000
S86 Injury of muscle and tendon at lower leg level
0.718 0.282 0.000
M00-M03 Infectious arthropathies
0.718 0.282 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
H54.9 Unspecified visual impairment (binocular)
0.717 0.283 0.000
M79.70 Fibromyalgia (Multiple sites)
0.717 0.283 0.000
M75 Shoulder lesions
0.716 0.284 0.000
J03.9 Acute tonsillitis, unspecified
0.715 0.285 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.715 0.285 0.000
J38.6 Stenosis of larynx
0.715 0.285 0.000
J38.5 Laryngeal spasm
0.715 0.285 0.000
I00-I02 Acute rheumatic fever
0.713 0.287 0.000
O08 Complications following abortion and ectopic and molar pregnancy
0.713 0.287 0.000
O07 Failed attempted abortion
0.713 0.287 0.000
O06 Unspecified abortion
0.713 0.287 0.000
O05 Other abortion
0.713 0.287 0.000
O01 Hydatidiform mole
0.713 0.287 0.000
M79.9 Soft tissue disorder, unspecified
0.713 0.287 0.000
M79.3 Panniculitis, unspecified
0.713 0.287 0.000
M54.1 Radiculopathy
0.713 0.287 0.000
I12.9 Hypertensive renal disease without renal failure
0.712 0.288 0.000
M65.9 Synovitis and tenosynovitis, unspecified
0.712 0.288 0.000
J06 Acute upper respiratory infections of multiple and unspecified sites
0.712 0.288 0.000
J30.1 Allergic rhinitis due to pollen
0.712 0.288 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.712 0.288 0.000
I72 Other aneurysm
0.712 0.288 0.000
H52.0 Hypermetropia
0.710 0.290 0.000
J13 Pneumonia due to Streptococcus pneumoniae
0.709 0.291 0.000
J00 Acute nasopharyngitis [common cold]
0.708 0.292 0.000
Chapter XX External causes of morbidity and mortality
0.707 0.293 0.000
Q80-Q89 Other congenital malformations
0.706 0.293 0.000
S82.30 Fracture of lower end of tibia (closed)
0.707 0.293 0.000
I77.5 Necrosis of artery
0.706 0.294 0.000
I77.4 Coeliac artery compression syndrome
0.706 0.294 0.000
I77.3 Arterial fibromuscular dysplasia
0.706 0.294 0.000
I77.2 Rupture of artery
0.706 0.294 0.000
I77.0 Arteriovenous fistula, acquired
0.706 0.294 0.000
F30 Manic episode
0.705 0.295 0.000
Q66 Congenital deformities of feet
0.705 0.295 0.000
T18 Foreign body in alimentary tract
0.705 0.295 0.000
S82.0 Fracture of patella
0.705 0.295 0.000
H04.5 Stenosis and insufficiency of lachrymal passages
0.705 0.295 0.000
M71.2 Synovial cyst of popliteal space [Baker]
0.704 0.296 0.000
O99.6 Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
0.704 0.296 0.000
M79.68 Pain in limb (Other)
0.704 0.296 0.000
M79.61 Pain in limb (Shoulder region)
0.704 0.296 0.000
G58 Other mononeuropathies
0.703 0.297 0.000
Q60-Q64 Congenital malformations of the urinary system
0.703 0.297 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.703 0.297 0.000
I27 Other pulmonary heart diseases
0.703 0.297 0.000
M54.36 Sciatica (Lumbar region)
0.702 0.297 0.000
J32.0 Chronic maxillary sinusitis
0.702 0.298 0.000
T33-T35 Frostbite
0.702 0.298 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.702 0.298 0.000
T00-T07 Injuries involving multiple body regions
0.702 0.298 0.000
H40-H42 Glaucoma
0.702 0.298 0.000
H03 Disorders of eyelid in diseases classified elsewhere
0.701 0.298 0.000
M84.1 Nonunion of fracture [pseudarthrosis]
0.701 0.299 0.000
H17 Corneal scars and opacities
0.701 0.299 0.000
S80 Superficial injury of lower leg
0.700 0.300 0.000
S83.5 Sprain and strain involving (anterior)(posterior) cruciate ligament of knee
0.700 0.300 0.000
M14 Arthropathies in other diseases classified elsewhere
0.699 0.301 0.000
M12 Other specific arthropathies
0.699 0.301 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.699 0.301 0.000
M08 Juvenile arthritis
0.699 0.301 0.000
O03.8 Complete or unspecified, with other and unspecified complications
0.698 0.302 0.000
O03.7 Complete or unspecified, complicated by embolism
0.698 0.302 0.000
O03.6 Complete or unspecified, complicated by delayed or excessive haemorrhage
0.698 0.302 0.000
O03.5 Complete or unspecified, complicated by genital tract and pelvic infection
0.698 0.302 0.000
O03.3 Incomplete, with other and unspecified complications
0.698 0.302 0.000
O03.2 Incomplete, complicated by embolism
0.698 0.302 0.000
O03.1 Incomplete, complicated by delayed or excessive haemorrhage
0.698 0.302 0.000
O03.0 Incomplete, complicated by genital tract and pelvic infection
0.698 0.302 0.000
H46 Optic neuritis
0.698 0.302 0.000
J37 Chronic laryngitis and laryngotracheitis
0.696 0.304 0.000
J38.2 Nodules of vocal cords
0.696 0.304 0.000
M54.8 Other dorsalgia
0.696 0.304 0.000
M54.0 Panniculitis affecting regions of neck and back
0.696 0.304 0.000
O85-O92 Complications predominantly related to the puerperium
0.695 0.305 0.000
J32.3 Chronic sphenoidal sinusitis
0.695 0.305 0.000
J32.1 Chronic frontal sinusitis
0.695 0.305 0.000
T79-T79 Certain early complications of trauma
0.694 0.306 0.000
I78 Diseases of capillaries
0.694 0.306 0.000
T93.9 Sequelae of unspecified injury of lower limb
0.693 0.306 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.693 0.306 0.000
H52.3 Anisometropia and aniseikonia
0.692 0.308 0.000
T92.0 Sequelae of open wound of upper limb
0.691 0.308 0.000
M42 Spinal osteochondrosis
0.691 0.309 0.000
M40 Kyphosis and lordosis
0.691 0.309 0.000
O02.9 Abnormal product of conception, unspecified
0.689 0.311 0.000
O02.8 Other specified abnormal products of conception
0.689 0.311 0.000
O02.0 Blighted ovum and nonhydatidiform mole
0.689 0.311 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.689 0.311 0.000
G44.0 Cluster headache syndrome
0.689 0.311 0.000
I71.3 Abdominal aortic aneurysm, ruptured
0.688 0.312 0.000
M51.2 Other specified intervertebral disk displacement
0.688 0.312 0.000
H00 Hordeolum and chalazion
0.688 0.312 0.000
H51 Other disorders of binocular movement
0.687 0.313 0.000
I05 Rheumatic mitral valve diseases
0.687 0.313 0.000
T66-T78 Other and unspecified effects of external causes
0.687 0.313 0.000
M54.39 Sciatica (Site unspecified)
0.686 0.313 0.000
T93.0 Sequelae of open wound of lower limb
0.686 0.314 0.000
M79.87 Other specified soft tissue disorders (Ankle and foot)
0.686 0.314 0.000
Q27 Other congenital malformations of peripheral vascular system
0.685 0.315 0.000
J86 Pyothorax
0.684 0.316 0.000
M80 Osteoporosis with pathological fracture
0.683 0.317 0.000
M17 Gonarthrosis [arthrosis of knee]
0.683 0.317 0.000
M53.3 Sacrococcygeal disorders, not elsewhere classified
0.683 0.317 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.683 0.317 0.000
Q35-Q37 Cleft lip and cleft palate
0.683 0.317 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.683 0.317 0.000
Q00-Q07 Congenital malformations of the nervous system
0.683 0.317 0.000
J33.9 Nasal polyp, unspecified
0.683 0.317 0.000
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.682 0.318 0.000
I15 Secondary hypertension
0.681 0.319 0.000
M75.1 Rotator cuff syndrome
0.680 0.320 0.000
S00-S09 Injuries to the head
0.680 0.320 0.000
J04 Acute laryngitis and tracheitis
0.679 0.321 0.000
M07 Psoriatic and enteropathic arthropathies
0.679 0.321 0.000
H05 Disorders of orbit
0.677 0.323 0.000
S83.6 Sprain and strain of other and unspecified parts of knee
0.677 0.323 0.000
O04 Medical abortion
0.677 0.323 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.676 0.324 0.000
H16 Keratitis
0.676 0.324 0.000
Q28 Other congenital malformations of circulatory system
0.676 0.324 0.000
M54.54 Low back pain-Thoracic
0.675 0.325 0.000
M54.53 Low back pain-Cervicothoracic
0.675 0.325 0.000
M54.52 Low back pain-Cervical
0.675 0.325 0.000
M54.51 Low back pain-Occipit-atl-axl
0.675 0.325 0.000
I77.8 Other specified disorders of arteries and arterioles
0.674 0.326 0.000
I51.0 Cardiac septal defect, acquired
0.674 0.326 0.000
H43.1 Vitreous haemorrhage
0.674 0.326 0.000
I74 Arterial embolism and thrombosis
0.674 0.326 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.673 0.326 0.000
G47 Sleep disorders
0.673 0.327 0.000
M41.96 Scoliosis, unspecified (Lumbar region)
0.672 0.328 0.000
H04.3 Acute and unspecified inflammation of lachrymal passages
0.672 0.328 0.000
H18.4 Corneal degeneration
0.670 0.330 0.000
M66 Spontaneous rupture of synovium and tendon
0.669 0.331 0.000
M89 Other disorders of bone
0.669 0.331 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.666 0.334 0.000
H22 Disorders of iris and ciliary body in diseases classified elsewhere
0.666 0.334 0.000
H19 Disorders of sclera and cornea in diseases classified elsewhere
0.666 0.334 0.000
H15 Disorders of sclera
0.666 0.334 0.000
Q21 Congenital malformations of cardiac septa
0.665 0.334 0.000
S10 Superficial injury of neck
0.665 0.335 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.664 0.335 0.000
T91 Sequelae of injuries of neck and trunk
0.664 0.336 0.000
S40 Superficial injury of shoulder and upper arm
0.663 0.336 0.000
T98 Sequelae of other and unspecified effects of external causes
0.663 0.337 0.000
T95 Sequelae of burns, corrosions and frostbite
0.663 0.337 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.663 0.337 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.663 0.337 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.663 0.337 0.000
O80-O84 Delivery
0.663 0.337 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.663 0.337 0.000
M83 Adult osteomalacia
0.663 0.337 0.000
M82 Osteoporosis in diseases classified elsewhere
0.663 0.337 0.000
S70-S79 Injuries to the hip and thigh
0.663 0.337 0.000
M43.17 Spondylolisthesis (Lumbosacral region)
0.662 0.338 0.000
M06.3 Rheumatoid nodule
0.661 0.339 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.661 0.339 0.000
M48 Other spondylopathies
0.661 0.339 0.000
H50.0 Convergent concomitant strabismus
0.660 0.340 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.660 0.340 0.000
S88 Traumatic amputation of lower leg
0.657 0.343 0.000
S87 Crushing injury of lower leg
0.657 0.343 0.000
S85 Injury of blood vessels at lower leg level
0.657 0.343 0.000
S84 Injury of nerves at lower leg level
0.657 0.343 0.000
O99.7 Diseases of the skin and subcutaneous tissue complicating pregnancy, childbirth and the puerperium
0.657 0.343 0.000
M54.4 Lumbago with sciatica
0.656 0.343 0.000
J34.1 Cyst and mucocele of nose and nasal sinus
0.656 0.344 0.000
J34.0 Abscess, furuncle and carbuncle of nose
0.656 0.344 0.000
I13 Hypertensive heart and renal disease
0.655 0.345 0.000
H04.8 Other disorders of lachrymal system
0.655 0.345 0.000
H54.0 Blindness, both eyes
0.654 0.346 0.000
G44.2 Tension-type headache
0.654 0.346 0.000
H20.8 Other iridocyclitis
0.654 0.346 0.000
G37.9 Demyelinating disease of central nervous system, unspecified
0.654 0.346 0.000
H57.1 Ocular pain
0.653 0.347 0.000
G57 Mononeuropathies of lower limb
0.653 0.347 0.000
G09 Sequelae of inflammatory diseases of central nervous system
0.652 0.348 0.000
I51.8 Other ill-defined heart diseases
0.652 0.348 0.000
Q50-Q56 Congenital malformations of genital organs
0.651 0.349 0.000
M54.9 Dorsalgia, unspecified
0.651 0.349 0.000
O99.8 Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
0.650 0.350 0.000
I45 Other conduction disorders
0.649 0.350 0.000
J05 Acute obstructive laryngitis [croup] and epiglottitis
0.648 0.352 0.000
M79.5 Residual foreign body in soft tissue
0.648 0.352 0.000
M79.82 Other specified soft tissue disorders (Upper arm)
0.647 0.353 0.000
O60-O75 Complications of labour and delivery
0.646 0.354 0.000
G03 Meningitis due to other and unspecified causes
0.646 0.354 0.000
M06.8 Other specified rheumatoid arthritis
0.646 0.354 0.000
M06.4 Inflammatory polyarthropathy
0.646 0.354 0.000
M06.2 Rheumatoid bursitis
0.646 0.354 0.000
M06.1 Adult-onset Still's disease
0.646 0.354 0.000
G58.9 Mononeuropathy, unspecified
0.645 0.355 0.000
H58.8 Visual disturbances in diseases classified elsewhere
0.645 0.355 0.000
M79.78 Fibromyalgia (Other)
0.645 0.355 0.000
M79.77 Fibromyalgia (Ankle and foot)
0.645 0.355 0.000
M79.76 Fibromyalgia (Lower leg)
0.645 0.355 0.000
M79.75 Fibromyalgia (Pelvic region and thigh)
0.645 0.355 0.000
M79.74 Fibromyalgia (Hand)
0.645 0.355 0.000
M79.73 Fibromyalgia (Forearm)
0.645 0.355 0.000
M79.72 Fibromyalgia (Upper arm)
0.645 0.355 0.000
M79.71 Fibromyalgia (Shoulder region)
0.645 0.355 0.000
G90-G99 Other disorders of the nervous system
0.644 0.356 0.000
M65.97 Synovitis and tenosynovitis, unspecified (Ankle and foot)
0.644 0.356 0.000
I49.4 Other and unspecified premature depolarisation
0.644 0.356 0.000
I71.8 Aortic aneurysm of unspecified site, ruptured
0.643 0.356 0.000
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.643 0.356 0.000
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.643 0.356 0.000
I71.1 Thoracic aortic aneurysm, ruptured
0.643 0.356 0.000
I71.0 Dissection of aorta [any part]
0.643 0.356 0.000
I49.0 Ventricular fibrillation and flutter
0.643 0.357 0.000
M43.9 Deforming dorsopathy, unspecified
0.643 0.357 0.000
M43.8 Other specified deforming dorsopathies
0.643 0.357 0.000
M43.6 Torticollis
0.643 0.357 0.000
M43.5 Other recurrent vertebral subluxation
0.643 0.357 0.000
M43.4 Other recurrent atlantoaxial subluxation
0.643 0.357 0.000
M43.3 Recurrent atlantoaxial subluxation with myelopathy
0.643 0.357 0.000
M43.2 Other fusion of spine
0.643 0.357 0.000
I50 Heart failure
0.643 0.357 0.000
M54.64 Pain in thoracic spine (Thoracic region)
0.641 0.359 0.000
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle
0.641 0.359 0.000
M46 Other inflammatory spondylopathies
0.641 0.359 0.000
M17.0 Primary gonarthrosis, bilateral
0.641 0.359 0.000
F60-F69 Disorders of adult personality and behaviour
0.640 0.360 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.640 0.360 0.000
F31.2 Bipolar affective disorder, current episode manic with psychotic symptoms
0.639 0.361 0.000
M51.0 Lumbar and other intervertebral disk disorders with myelopathy
0.638 0.362 0.000
J33.1 Polypoid sinus degeneration
0.638 0.362 0.000
O24 Diabetes mellitus in pregnancy
0.638 0.362 0.000
S82.6 Fracture of lateral malleolus
0.638 0.362 0.000
I49.1 Atrial premature depolarisation
0.638 0.362 0.000
J60-J70 Lung diseases due to external agents
0.637 0.363 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.637 0.363 0.000
F70-F79 Mental retardation
0.637 0.363 0.000
M13 Other arthritis
0.636 0.364 0.000
F31.0 Bipolar affective disorder, current episode hypomanic
0.636 0.364 0.000
M85.8 Other specified disorders of bone density and structure
0.635 0.365 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.634 0.366 0.000
T93.1 Sequelae of fracture of femur
0.633 0.367 0.000
I30 Acute pericarditis
0.632 0.368 0.000
J02 Acute pharyngitis
0.632 0.368 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.632 0.368 0.000
M54.57 Low back pain (Lumbosacral region)
0.632 0.368 0.000
S82.1 Fracture of upper end of tibia
0.632 0.368 0.000
I52 Other heart disorders in diseases classified elsewhere
0.631 0.369 0.000
I48 Atrial fibrillation and flutter
0.631 0.369 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.631 0.369 0.000
I41 Myocarditis in diseases classified elsewhere
0.631 0.369 0.000
I40 Acute myocarditis
0.631 0.369 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.631 0.369 0.000
I37 Pulmonary valve disorders
0.631 0.369 0.000
I32 Pericarditis in diseases classified elsewhere
0.631 0.369 0.000
O98 Maternal infectious and parasitic diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
0.631 0.369 0.000
O97 Death from sequelae of direct obstetric causes
0.631 0.369 0.000
O96 Death from any obstetric cause occurring more than 42 days but less than one year after delivery
0.631 0.369 0.000
O95 Obstetric death of unspecified cause
0.631 0.369 0.000
O94 Sequelae of complication of pregnancy, childbirth and the puerperium
0.631 0.369 0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.630 0.369 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.630 0.370 0.000
M84.12 Nonunion of fracture [pseudarthrosis] (Upper arm)
0.629 0.371 0.000
H25-H28 Disorders of lens
0.629 0.371 0.000
T92.2 Sequelae of fracture at wrist and hand level
0.629 0.371 0.000
H04.9 Disorder of lachrymal system, unspecified
0.628 0.372 0.000
H04.6 Other changes in lachrymal passages
0.628 0.372 0.000
H04.4 Chronic inflammation of lachrymal passages
0.628 0.372 0.000
H04.0 Dacryoadenitis
0.628 0.372 0.000
G56 Mononeuropathies of upper limb
0.628 0.372 0.000
H49.1 Fourth [trochlear] nerve palsy
0.628 0.372 0.000
H53.0 Amblyopia ex anopsia
0.628 0.372 0.000
F31.3 Bipolar affective disorder, current episode mild or moderate depression
0.627 0.373 0.000
H52.7 Disorder of refraction, unspecified
0.627 0.373 0.000
H52.6 Other disorders of refraction
0.627 0.373 0.000
H52.5 Disorders of accommodation
0.627 0.373 0.000
H52.4 Presbyopia
0.627 0.373 0.000
M79.89 Other specified soft tissue disorders (Site unspecified)
0.627 0.373 0.000
T18.1 Foreign body in oesophagus
0.626 0.374 0.000
F38 Other mood [affective] disorders
0.625 0.374 0.000
F34 Persistent mood [affective] disorders
0.625 0.374 0.000
F39 Unspecified mood [affective] disorder
0.625 0.374 0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.624 0.375 0.000
T43.4 Butyrophenone and thioxanthene neuroleptics
0.624 0.376 0.000
T23 Burn and corrosion of wrist and hand
0.624 0.376 0.000
T43.3 Phenothiazine antipsychotics and neuroleptics
0.623 0.377 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.623 0.377 0.000
I51.6 Cardiovascular disease, unspecified
0.623 0.377 0.000
I51.5 Myocardial degeneration
0.623 0.377 0.000
I51.4 Myocarditis, unspecified
0.623 0.377 0.000
I51.3 Intracardiac thrombosis, not elsewhere classified
0.623 0.377 0.000
I51.2 Rupture of papillary muscle, not elsewhere classified
0.623 0.377 0.000
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.623 0.377 0.000
S90-S99 Injuries to the ankle and foot
0.622 0.378 0.000
Chapter XXII Codes for special purposes
0.621 0.378 0.000
H54.6 Unqualified visual loss, one eye
0.620 0.380 0.000
H54.5 Low vision, one eye
0.620 0.380 0.000
H54.3 Unqualified visual loss, both eyes
0.620 0.380 0.000
H54.2 Low vision, both eyes
0.620 0.380 0.000
H54.1 Blindness, one eye, low vision, other eye
0.620 0.380 0.000
H43.2 Crystalline deposits in vitreous body
0.620 0.380 0.000
H50.1 Divergent concomitant strabismus
0.620 0.380 0.000
M10.97 Gout, unspecified (Ankle and foot)
0.620 0.380 0.000
S82.5 Fracture of medial malleolus
0.619 0.380 0.000
Chapter I Certain infectious and parasitic diseases
0.620 0.380 0.000
O20.8 Other haemorrhage in early pregnancy
0.619 0.381 0.000
I49.2 Junctional premature depolarisation
0.618 0.382 0.000
Q26 Congenital malformations of great veins
0.618 0.382 0.000
Q25 Congenital malformations of great arteries
0.618 0.382 0.000
Q23 Congenital malformations of aortic and mitral valves
0.618 0.382 0.000
Q22 Congenital malformations of pulmonary and tricuspid valves
0.618 0.382 0.000
Q20 Congenital malformations of cardiac chambers and connexions
0.618 0.382 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.618 0.382 0.000
M11.9 Crystal arthropathy, unspecified
0.617 0.383 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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