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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs78430185
log Bayes Factor = 8.27231
Chromosome 13   position 55,695,116  (GRCh37) Explore rs78430185 on Ensembl!
Variant rs78430185 is part of Cluster X0263

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter II Neoplasms
0.999 0.001 0.000
C15-C26 Malignant neoplasms of digestive organs
0.998 0.002 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.998 0.002 0.000
M40-M43 Deforming dorsopathies
0.991 0.009 0.000
M45-M49 Spondylopathies
0.989 0.011 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.988 0.012 0.000
E00-E07 Disorders of thyroid gland
0.986 0.014 0.000
M43 Other deforming dorsopathies
0.985 0.015 0.000
M20-M25 Other joint disorders
0.984 0.016 0.000
Chapter VI Diseases of the nervous system
0.984 0.016 0.000
M43.1 Spondylolisthesis
0.980 0.020 0.000
C19 Malignant neoplasm of rectosigmoid junction
0.977 0.023 0.000
E70-E90 Metabolic disorders
0.975 0.025 0.000
M86-M90 Other osteopathies
0.975 0.025 0.000
M43.16 Spondylolisthesis (Lumbar region)
0.974 0.026 0.000
M50-M54 Other dorsopathies
0.973 0.027 0.000
M25 Other joint disorders, not elsewhere classified
0.972 0.028 0.000
C20 Malignant neoplasm of rectum
0.969 0.031 0.000
M25.5 Pain in joint
0.966 0.034 0.000
M54 Dorsalgia
0.966 0.034 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.965 0.035 0.000
E04 Other non-toxic goitre
0.964 0.036 0.000
M54.9 Dorsalgia, unspecified
0.961 0.039 0.000
M47 Spondylosis
0.960 0.040 0.000
M25.55 Pain in joint (Pelvic region and thigh)
0.959 0.041 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.959 0.041 0.000
Chapter VIII Diseases of the ear and mastoid process
0.947 0.053 0.000
M54.99 Dorsalgia, unspecified (Site unspecified)
0.945 0.055 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.939 0.061 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.939 0.061 0.000
C25 Malignant neoplasm of pancreas
0.938 0.062 0.000
M05-M14 Inflammatory polyarthropathies
0.935 0.065 0.000
E86 Volume depletion
0.935 0.065 0.000
T90 Sequelae of injuries of head
0.934 0.066 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.930 0.070 0.000
E04.9 Non-toxic goitre, unspecified
0.928 0.072 0.000
M35 Other systemic involvement of connective tissue
0.918 0.082 0.000
M47.8 Other spondylosis
0.918 0.082 0.000
M80-M85 Disorders of bone density and structure
0.917 0.083 0.000
M25.57 Pain in joint (Ankle and foot)
0.893 0.107 0.000
S20-S29 Injuries to the thorax
0.889 0.111 0.000
M96 Postprocedural musculoskeletal disorders, not elsewhere classified
0.888 0.112 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.886 0.114 0.000
M47.86 Other spondylosis (Lumbar region)
0.885 0.115 0.000
M86 Osteomyelitis
0.879 0.121 0.000
E10-E14 Diabetes mellitus
0.879 0.121 0.000
Chapter VII Diseases of the eye and adnexa
0.871 0.129 0.000
G62 Other polyneuropathies
0.871 0.129 0.000
M48 Other spondylopathies
0.869 0.131 0.000
C17 Malignant neoplasm of small intestine
0.869 0.131 0.000
H65-H75 Diseases of middle ear and mastoid
0.867 0.133 0.000
S10-S19 Injuries to the neck
0.863 0.137 0.000
E07 Other disorders of thyroid
0.863 0.137 0.000
M06 Other rheumatoid arthritis
0.862 0.138 0.000
M07 Psoriatic and enteropathic arthropathies
0.858 0.142 0.000
M35.3 Polymyalgia rheumatica
0.857 0.143 0.000
T90.9 Sequelae of unspecified injury of head
0.854 0.146 0.000
M47.9 Spondylosis, unspecified
0.852 0.148 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.849 0.151 0.000
E11 Non-insulin-dependent diabetes mellitus
0.847 0.153 0.000
E03 Other hypothyroidism
0.844 0.156 0.000
M90 Osteopathies in diseases classified elsewhere
0.843 0.157 0.000
C92 Myeloid leukaemia
0.842 0.158 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.841 0.159 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.838 0.162 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.838 0.162 0.000
C21 Malignant neoplasm of anus and anal canal
0.831 0.169 0.000
M54.6 Pain in thoracic spine
0.830 0.170 0.000
T90.0 Sequelae of superficial injury of head
0.829 0.171 0.000
M46 Other inflammatory spondylopathies
0.829 0.171 0.000
M25.56 Pain in joint (Lower leg)
0.829 0.171 0.000
M54.94 Dorsalgia, unspecified (Thoracic region)
0.828 0.172 0.000
M80 Osteoporosis with pathological fracture
0.827 0.173 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.827 0.173 0.000
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.825 0.175 0.000
G60 Hereditary and idiopathic neuropathy
0.822 0.178 0.000
M43.17 Spondylolisthesis (Lumbosacral region)
0.821 0.179 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.819 0.181 0.000
H65 Nonsuppurative otitis media
0.819 0.181 0.000
M47.96 Spondylosis, unspecified (Lumbar region)
0.818 0.182 0.000
H90-H95 Other disorders of ear
0.817 0.183 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.817 0.183 0.000
M60-M63 Disorders of muscles
0.816 0.183 0.000
S90-S99 Injuries to the ankle and foot
0.812 0.188 0.000
M86.9 Osteomyelitis, unspecified
0.810 0.190 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.810 0.190 0.000
M54.90 Dorsalgia, unspecified (Multiple sites in spine)
0.809 0.191 0.000
Q60-Q64 Congenital malformations of the urinary system
0.807 0.193 0.000
M25.4 Effusion of joint
0.807 0.193 0.000
C25.9 Pancreas, unspecified
0.807 0.193 0.000
M07.3 Other psoriatic arthropathies
0.803 0.197 0.000
G30-G32 Other degenerative diseases of the nervous system
0.800 0.200 0.000
M91-M94 Chondropathies
0.800 0.200 0.000
M21 Other acquired deformities of limbs
0.798 0.202 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.795 0.205 0.000
G62.9 Polyneuropathy, unspecified
0.794 0.206 0.000
M88 Paget's disease of bone [osteitis deformans]
0.793 0.207 0.000
E73 Lactose intolerance
0.791 0.209 0.000
M54.97 Dorsalgia, unspecified (Lumbosacral region)
0.790 0.210 0.000
E11.5 With peripheral circulatory complications
0.790 0.210 0.000
T92 Sequelae of injuries of upper limb
0.789 0.210 0.000
E11.4 With neurological complications
0.789 0.211 0.000
M96.1 Postlaminectomy syndrome, not elsewhere classified
0.789 0.211 0.000
T66-T78 Other and unspecified effects of external causes
0.788 0.212 0.000
H30-H36 Disorders of choroid and retina
0.788 0.212 0.000
M54.2 Cervicalgia
0.785 0.215 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.784 0.216 0.000
M48.0 Spinal stenosis
0.781 0.219 0.000
C83 Diffuse non-Hodgkin's lymphoma
0.780 0.220 0.000
M24 Other specific joint derangements
0.778 0.222 0.000
M87 Osteonecrosis
0.778 0.222 0.000
C81 Hodgkin's disease
0.777 0.223 0.000
E04.1 Non-toxic single thyroid nodule
0.777 0.223 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.777 0.223 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.775 0.225 0.000
D80-D89 Certain disorders involving the immune mechanism
0.774 0.226 0.000
C25.0 Head of pancreas
0.774 0.226 0.000
M54.4 Lumbago with sciatica
0.774 0.226 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.774 0.226 0.000
S80-S89 Injuries to the knee and lower leg
0.771 0.229 0.000
M49 Spondylopathies in diseases classified elsewhere
0.771 0.229 0.000
C25.3 Pancreatic duct
0.766 0.234 0.000
M96.0 Pseudarthrosis after fusion or arthrodesis
0.765 0.235 0.000
E87.1 Hypo-osmolality and hyponatraemia
0.764 0.236 0.000
H65.3 Chronic mucoid otitis media
0.761 0.239 0.000
M86.97 Osteomyelitis, unspecified (Ankle and foot)
0.761 0.239 0.000
C91 Lymphoid leukaemia
0.760 0.240 0.000
E04.2 Non-toxic multinodular goitre
0.758 0.242 0.000
E50-E64 Other nutritional deficiencies
0.757 0.243 0.000
M84 Disorders of continuity of bone
0.756 0.243 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.754 0.246 0.000
T98 Sequelae of other and unspecified effects of external causes
0.754 0.246 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.753 0.247 0.000
S20 Superficial injury of thorax
0.753 0.247 0.000
H10-H13 Disorders of conjunctiva
0.753 0.247 0.000
M25.53 Pain in joint (Forearm)
0.752 0.248 0.000
M89 Other disorders of bone
0.751 0.249 0.000
M25.8 Other specified joint disorders
0.750 0.250 0.000
H73 Other disorders of tympanic membrane
0.750 0.250 0.000
S50-S59 Injuries to the elbow and forearm
0.749 0.251 0.000
M90.7 Fracture of bone in neoplastic disease
0.749 0.251 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.749 0.251 0.000
H90 Conductive and sensorineural hearing loss
0.748 0.252 0.000
C84 Peripheral and cutaneous T-cell lymphomas
0.746 0.254 0.000
H60-H62 Diseases of external ear
0.746 0.254 0.000
M43.0 Spondylolysis
0.746 0.254 0.000
M65-M68 Disorders of synovium and tendon
0.745 0.255 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.745 0.255 0.000
E07.9 Disorder of thyroid, unspecified
0.745 0.255 0.000
M85 Other disorders of bone density and structure
0.744 0.256 0.000
C92.0 Acute myeloid leukaemia
0.743 0.257 0.000
M30 Polyarteritis nodosa and related conditions
0.742 0.258 0.000
T91 Sequelae of injuries of neck and trunk
0.742 0.258 0.000
G55 Nerve root and plexus compressions in diseases classified elsewhere
0.742 0.258 0.000
Q21 Congenital malformations of cardiac septa
0.742 0.258 0.000
E03.9 Hypothyroidism, unspecified
0.741 0.259 0.000
M40 Kyphosis and lordosis
0.741 0.259 0.000
S27 Injury of other and unspecified intrathoracic organs
0.741 0.259 0.000
G70-G73 Diseases of myoneural junction and muscle
0.740 0.260 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.739 0.261 0.000
D86 Sarcoidosis
0.739 0.261 0.000
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts
0.736 0.264 0.000
S19 Other and unspecified injuries of neck
0.735 0.264 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.733 0.267 0.000
M54.64 Pain in thoracic spine (Thoracic region)
0.733 0.267 0.000
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.733 0.267 0.000
C07 Malignant neoplasm of parotid gland
0.733 0.267 0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.732 0.268 0.000
M96.8 Other postprocedural musculoskeletal disorders
0.731 0.269 0.000
C21.1 Anal canal
0.731 0.269 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.731 0.269 0.000
E85 Amyloidosis
0.730 0.270 0.000
E11.6 With other specified complications
0.730 0.270 0.000
T90.2 Sequelae of fracture of skull and facial bones
0.729 0.271 0.000
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites
0.729 0.271 0.000
M47.84 Other spondylosis (Thoracic region)
0.729 0.271 0.000
M25.9 Joint disorder, unspecified
0.728 0.272 0.000
Q80-Q89 Other congenital malformations
0.728 0.272 0.000
C90 Multiple myeloma and malignant plasma cell neoplasms
0.727 0.273 0.000
C26 Malignant neoplasm of other and ill-defined digestive organs
0.726 0.274 0.000
E89.0 Postprocedural hypothyroidism
0.725 0.275 0.000
T87 Complications peculiar to reattachment and amputation
0.725 0.275 0.000
M06.9 Rheumatoid arthritis, unspecified
0.725 0.275 0.000
M07.30 Other psoriatic arthropathies (Multiple sites)
0.724 0.276 0.000
M54.98 Dorsalgia, unspecified (Sacral and sacrococcygeal region)
0.723 0.277 0.000
C25.2 Tail of pancreas
0.721 0.279 0.000
G60.0 Hereditary motor and sensory neuropathy
0.721 0.279 0.000
E04.0 Non-toxic diffuse goitre
0.721 0.279 0.000
M21.0 Valgus deformity, not elsewhere classified
0.720 0.280 0.000
C18 Malignant neoplasm of colon
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.716 0.284 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.716 0.284 0.000
S92 Fracture of foot, except ankle
0.716 0.284 0.000
C17.2 Ileum
0.716 0.284 0.000
S22 Fracture of rib(s), sternum and thoracic spine
0.715 0.285 0.000
M80.0 Postmenopausal osteoporosis with pathological fracture
0.715 0.285 0.000
G62.8 Other specified polyneuropathies
0.714 0.286 0.000
M46.9 Inflammatory spondylopathy, unspecified
0.714 0.286 0.000
H35 Other retinal disorders
0.714 0.286 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.713 0.287 0.000
M48.06 Spinal stenosis (Lumbar region)
0.713 0.287 0.000
M25.47 Effusion of joint (Ankle and foot)
0.712 0.288 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.712 0.288 0.000
C23 Malignant neoplasm of gallbladder
0.711 0.288 0.000
M35.0 Sicca syndrome [Sjogren]
0.711 0.289 0.000
M42 Spinal osteochondrosis
0.711 0.289 0.000
M14 Arthropathies in other diseases classified elsewhere
0.710 0.290 0.000
T33-T35 Frostbite
0.708 0.292 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.708 0.292 0.000
T00-T07 Injuries involving multiple body regions
0.708 0.292 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.707 0.293 0.000
E00 Congenital iodine-deficiency syndrome
0.707 0.293 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.707 0.293 0.000
M05 Seropositive rheumatoid arthritis
0.707 0.293 0.000
M43.9 Deforming dorsopathy, unspecified
0.706 0.294 0.000
M43.8 Other specified deforming dorsopathies
0.706 0.294 0.000
M43.6 Torticollis
0.706 0.294 0.000
M43.5 Other recurrent vertebral subluxation
0.706 0.294 0.000
M43.4 Other recurrent atlantoaxial subluxation
0.706 0.294 0.000
M43.3 Recurrent atlantoaxial subluxation with myelopathy
0.706 0.294 0.000
M43.2 Other fusion of spine
0.706 0.294 0.000
M47.87 Other spondylosis (Lumbosacral region)
0.706 0.294 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.706 0.294 0.000
M33 Dermatopolymyositis
0.706 0.294 0.000
M32 Systemic lupus erythematosus
0.706 0.294 0.000
D00-D09 In situ neoplasms
0.704 0.296 0.000
M43.19 Spondylolisthesis (Site unspecified)
0.703 0.297 0.000
M43.18 Spondylolisthesis (Sacral and sacrococcygeal region)
0.703 0.297 0.000
M43.15 Spondylolisthesis (Thoracolumbar region)
0.703 0.297 0.000
M43.14 Spondylolisthesis (Thoracic region)
0.703 0.297 0.000
M43.13 Spondylolisthesis (Cervicothoracic region)
0.703 0.297 0.000
M43.12 Spondylolisthesis (Cervical region)
0.703 0.297 0.000
M43.11 Spondylolisthesis (Occipito-atlanto-axial region)
0.703 0.297 0.000
M43.10 Spondylolisthesis (Multiple sites in spine)
0.703 0.297 0.000
T82.5 Mechanical complication of other cardiac and vascular devices and implants
0.703 0.297 0.000
S70-S79 Injuries to the hip and thigh
0.702 0.298 0.000
C17.0 Duodenum
0.700 0.300 0.000
E84 Cystic fibrosis
0.699 0.301 0.000
E79 Disorders of purine and pyrimidine metabolism
0.699 0.301 0.000
E77 Disorders of glycoprotein metabolism
0.699 0.301 0.000
E76 Disorders of glycosaminoglycan metabolism
0.699 0.301 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.699 0.301 0.000
E74 Other disorders of carbohydrate metabolism
0.699 0.301 0.000
E72 Other disorders of amino-acid metabolism
0.699 0.301 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.699 0.301 0.000
E70 Disorders of aromatic amino-acid metabolism
0.699 0.301 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.699 0.301 0.000
G59 Mononeuropathy in diseases classified elsewhere
0.698 0.301 0.000
M25.2 Flail joint
0.697 0.303 0.000
M25.1 Fistula of joint
0.697 0.303 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.697 0.303 0.000
D86.0 Sarcoidosis of lung
0.696 0.304 0.000
M06.0 Seronegative rheumatoid arthritis
0.696 0.304 0.000
G40-G47 Episodic and paroxysmal disorders
0.695 0.305 0.000
H35.8 Other specified retinal disorders
0.695 0.305 0.000
M25.54 Pain in joint (Hand)
0.695 0.305 0.000
H69 Other disorders of Eustachian tube
0.694 0.306 0.000
T90.4 Sequelae of injury of eye and orbit
0.693 0.307 0.000
M25.58 Pain in joint (Other)
0.692 0.307 0.000
Q00-Q07 Congenital malformations of the nervous system
0.692 0.307 0.000
M54.8 Other dorsalgia
0.692 0.307 0.000
M54.0 Panniculitis affecting regions of neck and back
0.692 0.307 0.000
T95 Sequelae of burns, corrosions and frostbite
0.691 0.308 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.691 0.308 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.691 0.308 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.691 0.309 0.000
E04.8 Other specified non-toxic goitre
0.691 0.309 0.000
G20-G26 Extrapyramidal and movement disorders
0.691 0.309 0.000
C22.1 Intrahepatic bile duct carcinoma
0.690 0.310 0.000
M07.39 Other psoriatic arthropathies (Site unspecified)
0.690 0.310 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.689 0.310 0.000
M54.95 Dorsalgia, unspecified (Thoracolumbar region)
0.689 0.311 0.000
M54.93 Dorsalgia, unspecified (Cervicothoracic region)
0.689 0.311 0.000
M54.92 Dorsalgia, unspecified (Cervical region)
0.689 0.311 0.000
M54.91 Dorsalgia, unspecified (Occipito-atlanto-axial region)
0.689 0.311 0.000
M47.0 Anterior spinal and vertebral artery compression syndromes
0.688 0.312 0.000
C64-C68 Malignant neoplasms of urinary tract
0.688 0.312 0.000
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.688 0.312 0.000
C95 Leukaemia of unspecified cell type
0.688 0.312 0.000
C94 Other leukaemias of specified cell type
0.688 0.312 0.000
C93 Monocytic leukaemia
0.688 0.312 0.000
C86 Other specified types of T/NK-cell lymphoma
0.688 0.312 0.000
C88 Malignant immunoproliferative diseases
0.687 0.313 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.686 0.313 0.000
Q21.1 Atrial septal defect
0.686 0.313 0.000
M47.82 Other spondylosis (Cervical region)
0.686 0.314 0.000
G30 Alzheimer's disease
0.684 0.316 0.000
M06.4 Inflammatory polyarthropathy
0.683 0.317 0.000
M47.2 Other spondylosis with radiculopathy
0.682 0.318 0.000
E07.8 Other specified disorders of thyroid
0.681 0.319 0.000
H55-H59 Other disorders of eye and adnexa
0.680 0.320 0.000
M25.59 Pain in joint (Site unspecified)
0.679 0.321 0.000
G55.3 Nerve root and plexus compressions in other dorsopathies
0.679 0.321 0.000
M00-M03 Infectious arthropathies
0.679 0.321 0.000
S82 Fracture of lower leg, including ankle
0.679 0.321 0.000
H90.3 Sensorineural hearing loss, bilateral
0.678 0.322 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.677 0.322 0.000
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands
0.676 0.324 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.676 0.324 0.000
T78 Adverse effects, not elsewhere classified
0.675 0.325 0.000
M06.3 Rheumatoid nodule
0.674 0.325 0.000
E06 Thyroiditis
0.674 0.326 0.000
G64 Other disorders of peripheral nervous system
0.673 0.327 0.000
M84.1 Nonunion of fracture [pseudarthrosis]
0.673 0.327 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.673 0.327 0.000
Q35-Q37 Cleft lip and cleft palate
0.673 0.327 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.673 0.327 0.000
H70 Mastoiditis and related conditions
0.673 0.327 0.000
C25.8 Overlapping lesion of pancreas
0.673 0.327 0.000
C25.7 Other parts of pancreas
0.673 0.327 0.000
C25.4 Endocrine pancreas
0.673 0.327 0.000
C25.1 Body of pancreas
0.673 0.327 0.000
C11 Malignant neoplasm of nasopharynx
0.673 0.327 0.000
H04 Disorders of lachrymal system
0.672 0.328 0.000
M12 Other specific arthropathies
0.671 0.329 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.671 0.329 0.000
M08 Juvenile arthritis
0.671 0.329 0.000
M47.80 Other spondylosis (Multiple sites in spine)
0.671 0.329 0.000
T90.8 Sequelae of other specified injuries of head
0.669 0.331 0.000
T90.3 Sequelae of injury of cranial nerves
0.669 0.331 0.000
T90.1 Sequelae of open wound of head
0.669 0.331 0.000
M82 Osteoporosis in diseases classified elsewhere
0.669 0.331 0.000
M90.78 Fracture of bone in neoplastic disease (Other)
0.668 0.332 0.000
T90.5 Sequelae of intracranial injury
0.667 0.333 0.000
M35.7 Hypermobility syndrome
0.667 0.333 0.000
Q63 Other congenital malformations of kidney
0.667 0.333 0.000
M99 Biomechanical lesions, not elsewhere classified
0.667 0.333 0.000
E88 Other metabolic disorders
0.667 0.333 0.000
T82.2 Mechanical complication of coronary artery bypass and valve grafts
0.666 0.334 0.000
H73.8 Other specified disorders of tympanic membrane
0.666 0.334 0.000
S89 Other and unspecified injuries of lower leg
0.665 0.335 0.000
M41 Scoliosis
0.664 0.336 0.000
D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs
0.664 0.336 0.000
S12 Fracture of neck
0.664 0.336 0.000
Q50-Q56 Congenital malformations of genital organs
0.663 0.337 0.000
M62 Other disorders of muscle
0.663 0.337 0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis
0.663 0.337 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.662 0.338 0.000
S82.1 Fracture of upper end of tibia
0.662 0.338 0.000
M88.9 Paget's disease of bone, unspecified
0.662 0.338 0.000
M80.9 Unspecified osteoporosis with pathological fracture
0.660 0.340 0.000
E73.9 Lactose intolerance, unspecified
0.659 0.341 0.000
M35.9 Systemic involvement of connective tissue, unspecified
0.658 0.341 0.000
M35.8 Other specified systemic involvement of connective tissue
0.658 0.341 0.000
M35.6 Relapsing panniculitis [Weber-Christian]
0.658 0.341 0.000
M35.5 Multifocal fibrosclerosis
0.658 0.341 0.000
M35.4 Diffuse (eosinophilic) fasciitis
0.658 0.341 0.000
M35.2 Behcet's disease
0.658 0.341 0.000
M35.1 Other overlap syndromes
0.658 0.341 0.000
M47.88 Other spondylosis (Sacral and sacrococcygeal region)
0.658 0.342 0.000
M47.85 Other spondylosis (Thoracolumbar region)
0.658 0.342 0.000
M47.83 Other spondylosis (Cervicothoracic region)
0.658 0.342 0.000
M47.81 Other spondylosis (Occipito-atlanto-axial region)
0.658 0.342 0.000
G83 Other paralytic syndromes
0.658 0.342 0.000
M83 Adult osteomalacia
0.658 0.342 0.000
E87.5 Hyperkalaemia
0.657 0.343 0.000
T14 Injury of unspecified body region
0.656 0.344 0.000
T83.1 Mechanical complication of other urinary devices and implants
0.655 0.345 0.000
E11.2 With renal complications
0.654 0.346 0.000
G90-G99 Other disorders of the nervous system
0.653 0.347 0.000
H65.9 Nonsuppurative otitis media, unspecified
0.652 0.348 0.000
C10 Malignant neoplasm of oropharynx
0.651 0.349 0.000
C17.9 Small intestine, unspecified
0.651 0.349 0.000
S82.10 Fracture of upper end of tibia (closed)
0.651 0.349 0.000
M25.0 Haemarthrosis
0.651 0.349 0.000
G37 Other demyelinating diseases of central nervous system
0.650 0.350 0.000
S20.2 Contusion of thorax
0.650 0.350 0.000
Chapter XXII Codes for special purposes
0.650 0.350 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.649 0.351 0.000
H33 Retinal detachments and breaks
0.648 0.352 0.000
H11 Other disorders of conjunctiva
0.647 0.353 0.000
M34 Systemic sclerosis
0.647 0.353 0.000
M47.90 Spondylosis, unspecified (Multiple sites in spine)
0.646 0.354 0.000
S19.9 Unspecified injury of neck
0.644 0.356 0.000
E13 Other specified diabetes mellitus
0.644 0.356 0.000
E11.1 With ketoacidosis
0.643 0.357 0.000
M92 Other juvenile osteochondrosis
0.641 0.359 0.000
D05 Carcinoma in situ of breast
0.641 0.359 0.000
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.641 0.359 0.000
S10 Superficial injury of neck
0.640 0.360 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.639 0.361 0.000
M53 Other dorsopathies, not elsewhere classified
0.639 0.361 0.000
M80.1 Postoophorectomy osteoporosis with pathological fracture
0.639 0.361 0.000
M47.97 Spondylosis, unspecified (Lumbosacral region)
0.638 0.362 0.000
M25.3 Other instability of joint
0.638 0.362 0.000
C92.1 Chronic myeloid leukaemia
0.638 0.362 0.000
S28 Crushing injury of thorax and traumatic amputation of part of thorax
0.638 0.362 0.000
S26 Injury of heart
0.638 0.362 0.000
S25 Injury of blood vessels of thorax
0.638 0.362 0.000
S24 Injury of nerves and spinal cord at thorax level
0.638 0.362 0.000
S23 Dislocation, sprain and strain of joints and ligaments of thorax
0.638 0.362 0.000
S21 Open wound of thorax
0.638 0.362 0.000
G55.0 Nerve root and plexus compressions in neoplastic disease
0.637 0.363 0.000
M96.6 Fracture of bone following insertion of orthopaedic implant, joint prosthesis or bone plate
0.637 0.363 0.000
M96.9 Postprocedural musculoskeletal disorder, unspecified
0.637 0.363 0.000
M96.5 Postradiation scoliosis
0.637 0.363 0.000
M96.4 Postsurgical lordosis
0.637 0.363 0.000
M96.3 Postlaminectomy kyphosis
0.637 0.363 0.000
M96.2 Postradiation kyphosis
0.637 0.363 0.000
T79-T79 Certain early complications of trauma
0.637 0.363 0.000
M31 Other necrotising vasculopathies
0.636 0.364 0.000
T92.6 Sequelae of crushing injury and traumatic amputation of upper limb
0.635 0.365 0.000
S14 Injury of nerves and spinal cord at neck level
0.635 0.365 0.000
C51-C58 Malignant neoplasms of female genital organs
0.635 0.365 0.000
M80.00 Postmenopausal osteoporosis with pathological fracture (Multiple sites)
0.634 0.366 0.000
Q27 Other congenital malformations of peripheral vascular system
0.633 0.367 0.000
E89.2 Postprocedural hypoparathyroidism
0.633 0.367 0.000
M54.29 Cervicalgia-Site unspe
0.633 0.367 0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.632 0.368 0.000
C01 Malignant neoplasm of base of tongue
0.631 0.369 0.000
G60.8 Other hereditary and idiopathic neuropathies
0.631 0.369 0.000
E87.2 Acidosis
0.631 0.369 0.000
S40-S49 Injuries to the shoulder and upper arm
0.630 0.370 0.000
E83 Disorders of mineral metabolism
0.630 0.370 0.000
M86.8 Other osteomyelitis
0.630 0.370 0.000
M86.6 Other chronic osteomyelitis
0.630 0.370 0.000
M86.5 Other chronic haematogenous osteomyelitis
0.630 0.370 0.000
M86.4 Chronic osteomyelitis with draining sinus
0.630 0.370 0.000
M86.3 Chronic multifocal osteomyelitis
0.630 0.370 0.000
M86.2 Subacute osteomyelitis
0.630 0.370 0.000
M86.1 Other acute osteomyelitis
0.630 0.370 0.000
M86.0 Acute haematogenous osteomyelitis
0.630 0.370 0.000
E12 Malnutrition-related diabetes mellitus
0.630 0.370 0.000
M48.5 Collapsed vertebra, not elsewhere classified
0.630 0.370 0.000
D46 Myelodysplastic syndromes
0.629 0.371 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.629 0.371 0.000
Q64 Other congenital malformations of urinary system
0.628 0.372 0.000
D45 Polycythaemia vera
0.628 0.372 0.000
M11 Other crystal arthropathies
0.628 0.372 0.000
M94 Other disorders of cartilage
0.627 0.373 0.000
T82.4 Mechanical complication of vascular dialysis catheter
0.626 0.374 0.000
D55-D59 Haemolytic anaemias
0.626 0.374 0.000
C83.0 Small cell (diffuse)
0.625 0.374 0.000
G08 Intracranial and intraspinal phlebitis and thrombophlebitis
0.625 0.375 0.000
G51 Facial nerve disorders
0.625 0.375 0.000
G62.2 Polyneuropathy due to other toxic agents
0.624 0.375 0.000
G62.1 Alcoholic polyneuropathy
0.624 0.375 0.000
G62.0 Drug-induced polyneuropathy
0.624 0.375 0.000
G61 Inflammatory polyneuropathy
0.624 0.376 0.000
E40-E46 Malnutrition
0.623 0.377 0.000
M48.9 Spondylopathy, unspecified
0.623 0.377 0.000
M48.8 Other specified spondylopathies
0.623 0.377 0.000
M48.4 Fatigue fracture of vertebra
0.623 0.377 0.000
M48.3 Traumatic spondylopathy
0.623 0.377 0.000
M48.2 Kissing spine
0.623 0.377 0.000
M48.1 Ankylosing hyperostosis [Forestier]
0.623 0.377 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.623 0.377 0.000
C17.8 Overlapping lesion of small intestine
0.623 0.377 0.000
C17.3 Meckel's diverticulum
0.623 0.377 0.000
C17.1 Jejunum
0.623 0.377 0.000
M47.1 Other spondylosis with myelopathy
0.623 0.377 0.000
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere
0.622 0.378 0.000
H68 Eustachian salpingitis and obstruction
0.622 0.378 0.000
H67 Otitis media in diseases classified elsewhere
0.622 0.378 0.000
M51 Other intervertebral disk disorders
0.621 0.379 0.000
M95 Other acquired deformities of musculoskeletal system and connective tissue
0.620 0.380 0.000
M54.3 Sciatica
0.620 0.380 0.000
M21.07 Valgus deformity, not elsewhere classified (Ankle and foot)
0.619 0.380 0.000
H65.4 Other chronic nonsuppurative otitis media
0.619 0.381 0.000
S17 Crushing injury of neck
0.619 0.381 0.000
S15 Injury of blood vessels at neck level
0.619 0.381 0.000
S11 Open wound of neck
0.619 0.381 0.000
S18 Traumatic amputation at neck level
0.619 0.381 0.000
S16 Injury of muscle and tendon at neck level
0.619 0.381 0.000
C91.1 Chronic lymphocytic leukaemia
0.619 0.381 0.000
T91.9 Sequelae of unspecified injury of neck and trunk
0.619 0.381 0.000
E07.1 Dyshormogenetic goitre
0.619 0.381 0.000
E07.0 Hypersecretion of calcitonin
0.619 0.381 0.000
S13 Dislocation, sprain and strain of joints and ligaments at neck level
0.619 0.381 0.000
M60 Myositis
0.619 0.381 0.000
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.618 0.381 0.000
M06.8 Other specified rheumatoid arthritis
0.618 0.382 0.000
M06.2 Rheumatoid bursitis
0.618 0.382 0.000
M06.1 Adult-onset Still's disease
0.618 0.382 0.000
G40 Epilepsy
0.618 0.382 0.000
C81.1 Nodular sclerosis
0.616 0.383 0.000
M07.6 Other enteropathic arthropathies
0.615 0.385 0.000
M07.5 Arthropathy in ulcerative colitis
0.615 0.385 0.000
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.615 0.385 0.000
M07.2 Psoriatic spondylitis
0.615 0.385 0.000
M07.1 Arthritis mutilans
0.615 0.385 0.000
M07.0 Distal interphalangeal psoriatic arthropathy
0.615 0.385 0.000
C85.1 B-cell lymphoma, unspecified
0.615 0.385 0.000
M87.9 Osteonecrosis, unspecified
0.615 0.385 0.000
T92.0 Sequelae of open wound of upper limb
0.615 0.385 0.000
M48.09 Spinal stenosis (Site unspecified)
0.614 0.386 0.000
M46.96 Inflammatory spondylopathy, unspecified (Lumbar region)
0.614 0.386 0.000
M49.5 Collapsed vertebra in diseases classified elsewhere
0.614 0.386 0.000
E20-E35 Disorders of other endocrine glands
0.614 0.386 0.000
G59.0 Diabetic mononeuropathy
0.613 0.387 0.000
T92.5 Sequelae of injury of muscle and tendon of upper limb
0.613 0.387 0.000
M45 Ankylosing spondylitis
0.613 0.387 0.000
T92.9 Sequelae of unspecified injury of upper limb
0.612 0.388 0.000
D48.6 Breast
0.612 0.388 0.000
M89.9 Disorder of bone, unspecified
0.612 0.388 0.000
Q61 Cystic kidney disease
0.611 0.389 0.000
M47.98 Spondylosis, unspecified (Sacral and sacrococcygeal region)
0.611 0.389 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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