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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs78437391
log Bayes Factor = 22.4064
Chromosome 12   position 129,229,615  (GRCh37) Explore rs78437391 on Ensembl!
Variant rs78437391 is part of Cluster X0030

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
Chapter II Neoplasms
0.998 0.002 0.000
Chapter XI Diseases of the digestive system
0.998 0.002 0.000
Chapter XX External causes of morbidity and mortality
0.998 0.002 0.000
M05-M14 Inflammatory polyarthropathies
0.998 0.002 0.000
M20-M25 Other joint disorders
0.997 0.003 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.997 0.003 0.000
K70-K77 Diseases of liver
0.997 0.003 0.000
K00-K14 Diseases of oral cavity, salivary glands and jaws
0.996 0.004 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.996 0.004 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.996 0.004 0.000
M06 Other rheumatoid arthritis
0.996 0.004 0.000
Chapter IX Diseases of the circulatory system
0.995 0.005 0.000
M06.9 Rheumatoid arthritis, unspecified
0.994 0.006 0.000
Chapter X Diseases of the respiratory system
0.994 0.006 0.000
C34 Malignant neoplasm of bronchus and lung
0.994 0.006 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.993 0.007 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.993 0.007 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.992 0.008 0.000
Chapter VI Diseases of the nervous system
0.991 0.009 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.990 0.010 0.000
K08 Other disorders of teeth and supporting structures
0.989 0.011 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.988 0.012 0.000
C79 Secondary malignant neoplasm of other sites
0.985 0.015 0.000
K08.3 Retained dental root
0.984 0.016 0.000
W00-W19 Falls
0.983 0.017 0.000
Chapter I Certain infectious and parasitic diseases
0.982 0.018 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.981 0.019 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.980 0.020 0.000
I10-I15 Hypertensive diseases
0.980 0.020 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.977 0.023 0.000
J90-J94 Other diseases of pleura
0.975 0.025 0.000
L02 Cutaneous abscess, furuncle and carbuncle
0.974 0.026 0.000
C79.5 Secondary malignant neoplasm of bone and bone marrow
0.971 0.029 0.000
I12 Hypertensive renal disease
0.967 0.033 0.000
E10-E14 Diabetes mellitus
0.966 0.034 0.000
C34.1 Upper lobe, bronchus or lung
0.964 0.036 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.959 0.041 0.000
W19 Unspecified fall
0.959 0.041 0.000
C34.9 Bronchus or lung, unspecified
0.958 0.042 0.000
I12.0 Hypertensive renal disease with renal failure
0.957 0.043 0.000
J90 Pleural effusion, not elsewhere classified
0.953 0.047 0.000
A30-A49 Other bacterial diseases
0.946 0.054 0.000
K70 Alcoholic liver disease
0.943 0.057 0.000
M20 Acquired deformities of fingers and toes
0.943 0.057 0.000
E11 Non-insulin-dependent diabetes mellitus
0.941 0.059 0.000
L02.4 Cutaneous abscess, furuncle and carbuncle of limb
0.937 0.063 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.936 0.064 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.935 0.065 0.000
M70-M79 Other soft tissue disorders
0.933 0.067 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.928 0.072 0.000
I30-I52 Other forms of heart disease
0.924 0.076 0.000
Chapter XXII Codes for special purposes
0.923 0.077 0.000
G90-G99 Other disorders of the nervous system
0.922 0.078 0.000
S70-S79 Injuries to the hip and thigh
0.915 0.084 0.000
M25 Other joint disorders, not elsewhere classified
0.914 0.086 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.911 0.089 0.000
A41 Other septicaemia
0.911 0.089 0.000
L03 Cellulitis
0.910 0.090 0.000
K76 Other diseases of liver
0.909 0.091 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.909 0.091 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.909 0.091 0.000
W19.9 Unspecified place
0.906 0.094 0.000
E70-E90 Metabolic disorders
0.905 0.095 0.000
B35-B49 Mycoses
0.901 0.099 0.000
K75 Other inflammatory liver diseases
0.899 0.101 0.000
W19.4 Street and highway
0.897 0.103 0.000
M80-M85 Disorders of bone density and structure
0.896 0.104 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.894 0.106 0.000
O36 Maternal care for other known or suspected foetal problems
0.893 0.107 0.000
M25.4 Effusion of joint
0.891 0.109 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.890 0.110 0.000
K74 Fibrosis and cirrhosis of liver
0.890 0.110 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.889 0.111 0.000
K04 Diseases of pulp and periapical tissues
0.885 0.115 0.000
O42 Premature rupture of membranes
0.885 0.115 0.000
A41.5 Septicaemia due to other Gram-negative organisms
0.884 0.116 0.000
E10 Insulin-dependent diabetes mellitus
0.882 0.118 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.881 0.119 0.000
Chapter VII Diseases of the eye and adnexa
0.877 0.123 0.000
G57 Mononeuropathies of lower limb
0.876 0.124 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.876 0.124 0.000
E11.9 Without complications
0.873 0.127 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.873 0.127 0.000
M79.8 Other specified soft tissue disorders
0.872 0.128 0.000
D69 Purpura and other haemorrhagic conditions
0.872 0.128 0.000
L60-L75 Disorders of skin appendages
0.872 0.128 0.000
K70.3 Alcoholic cirrhosis of liver
0.871 0.129 0.000
I49 Other cardiac arrhythmias
0.870 0.130 0.000
J84 Other interstitial pulmonary diseases
0.868 0.132 0.000
M25.46 Effusion of joint (Lower leg)
0.867 0.133 0.000
M23 Internal derangement of knee
0.864 0.136 0.000
G62 Other polyneuropathies
0.863 0.137 0.000
L08 Other local infections of skin and subcutaneous tissue
0.860 0.140 0.000
G30-G32 Other degenerative diseases of the nervous system
0.860 0.140 0.000
Q60-Q64 Congenital malformations of the urinary system
0.859 0.141 0.000
T66-T78 Other and unspecified effects of external causes
0.858 0.142 0.000
M20.5 Other deformities of toe(s) (acquired)
0.857 0.143 0.000
E83 Disorders of mineral metabolism
0.857 0.143 0.000
M20.6 Acquired deformity of toe(s), unspecified
0.857 0.143 0.000
O48 Prolonged pregnancy
0.857 0.143 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.856 0.144 0.000
M11 Other crystal arthropathies
0.855 0.145 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.853 0.147 0.000
C79.7 Secondary malignant neoplasm of adrenal gland
0.853 0.147 0.000
G57.6 Lesion of plantar nerve
0.848 0.152 0.000
K65-K67 Diseases of peritoneum
0.847 0.153 0.000
O32 Maternal care for known or suspected malpresentation of foetus
0.846 0.154 0.000
Chapter VIII Diseases of the ear and mastoid process
0.845 0.155 0.000
M21 Other acquired deformities of limbs
0.845 0.155 0.000
L02.1 Cutaneous abscess, furuncle and carbuncle of neck
0.844 0.156 0.000
C79.3 Secondary malignant neoplasm of brain and cerebral meninges
0.842 0.158 0.000
O47 False labour
0.842 0.158 0.000
J09-J18 Influenza and pneumonia
0.841 0.159 0.000
O42.9 Premature rupture of membranes, unspecified
0.840 0.160 0.000
I31 Other diseases of pericardium
0.839 0.161 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.839 0.161 0.000
C34.3 Lower lobe, bronchus or lung
0.838 0.162 0.000
I85 Oesophageal varices
0.837 0.163 0.000
K07 Dentofacial anomalies [including malocclusion]
0.835 0.165 0.000
G20-G26 Extrapyramidal and movement disorders
0.834 0.166 0.000
M79.86 Other specified soft tissue disorders (Lower leg)
0.832 0.168 0.000
S30 Superficial injury of abdomen, lower back and pelvis
0.830 0.170 0.000
D69.6 Thrombocytopenia, unspecified
0.829 0.171 0.000
L03.0 Cellulitis of finger and toe
0.828 0.172 0.000
S80-S89 Injuries to the knee and lower leg
0.827 0.173 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.826 0.174 0.000
C80 Malignant neoplasm without specification of site
0.826 0.174 0.000
G62.9 Polyneuropathy, unspecified
0.824 0.176 0.000
K70.4 Alcoholic hepatic failure
0.824 0.176 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.822 0.178 0.000
M31 Other necrotising vasculopathies
0.822 0.178 0.000
I49.9 Cardiac arrhythmia, unspecified
0.821 0.179 0.000
D60-D64 Aplastic and other anaemias
0.820 0.180 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.820 0.180 0.000
B37 Candidiasis
0.819 0.181 0.000
M22 Disorders of patella
0.818 0.182 0.000
Y45.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.815 0.185 0.000
M06.0 Seronegative rheumatoid arthritis
0.814 0.186 0.000
U80 Agent resistant to penicillin and related antibiotics
0.812 0.188 0.000
Y52 Agents primarily affecting the cardiovascular system
0.812 0.188 0.000
W11 Fall on and from ladder
0.811 0.189 0.000
Y40 Systemic antibiotics
0.808 0.192 0.000
J81 Pulmonary oedema
0.807 0.193 0.000
O30 Multiple gestation
0.807 0.193 0.000
M84 Disorders of continuity of bone
0.806 0.194 0.000
H65-H75 Diseases of middle ear and mastoid
0.806 0.194 0.000
I11 Hypertensive heart disease
0.806 0.194 0.000
D50-D53 Nutritional anaemias
0.805 0.195 0.000
Q61 Cystic kidney disease
0.804 0.196 0.000
K10 Other diseases of jaws
0.802 0.198 0.000
J95-J99 Other diseases of the respiratory system
0.800 0.200 0.000
G93 Other disorders of brain
0.800 0.200 0.000
J84.1 Other interstitial pulmonary diseases with fibrosis
0.800 0.200 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.799 0.201 0.000
M07 Psoriatic and enteropathic arthropathies
0.797 0.203 0.000
O41 Other disorders of amniotic fluid and membranes
0.796 0.204 0.000
S10-S19 Injuries to the neck
0.796 0.204 0.000
K73 Chronic hepatitis, not elsewhere classified
0.796 0.204 0.000
J30-J39 Other diseases of upper respiratory tract
0.795 0.205 0.000
C34.0 Main bronchus
0.794 0.206 0.000
M86-M90 Other osteopathies
0.794 0.206 0.000
E11.3 With ophthalmic complications
0.792 0.208 0.000
I50 Heart failure
0.789 0.211 0.000
L20-L30 Dermatitis and eczema
0.788 0.212 0.000
I31.9 Disease of pericardium, unspecified
0.788 0.212 0.000
K08.1 Loss of teeth due to accident, extraction or local periodontal disease
0.787 0.213 0.000
D75 Other diseases of blood and blood-forming organs
0.786 0.214 0.000
K75.4 Autoimmune hepatitis
0.785 0.214 0.000
K76.6 Portal hypertension
0.785 0.215 0.000
S50-S59 Injuries to the elbow and forearm
0.785 0.215 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.784 0.216 0.000
Y43 Primarily systemic agents
0.784 0.216 0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.783 0.217 0.000
M23.3 Other meniscus derangements
0.782 0.218 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.782 0.218 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.781 0.219 0.000
S72 Fracture of femur
0.779 0.221 0.000
K13 Other diseases of lip and oral mucosa
0.778 0.222 0.000
K72 Hepatic failure, not elsewhere classified
0.778 0.222 0.000
O43 Placental disorders
0.777 0.222 0.000
G91 Hydrocephalus
0.777 0.223 0.000
I85.9 Oesophageal varices without bleeding
0.777 0.223 0.000
K74.6 Other and unspecified cirrhosis of liver
0.775 0.224 0.000
M79.2 Neuralgia and neuritis, unspecified
0.774 0.226 0.000
A46 Erysipelas
0.774 0.226 0.000
D68 Other coagulation defects
0.774 0.226 0.000
D45 Polycythaemia vera
0.772 0.227 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.772 0.228 0.000
I45 Other conduction disorders
0.771 0.229 0.000
S90-S99 Injuries to the ankle and foot
0.771 0.229 0.000
J80 Adult respiratory distress syndrome
0.768 0.232 0.000
W20-W49 Exposure to inanimate mechanical forces
0.768 0.232 0.000
J82 Pulmonary eosinophilia, not elsewhere classified
0.766 0.234 0.000
Y57 Other and unspecified drugs and medicaments
0.766 0.234 0.000
S60-S69 Injuries to the wrist and hand
0.766 0.234 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.766 0.234 0.000
A41.1 Septicaemia due to other specified staphylococcus
0.765 0.235 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.765 0.235 0.000
S70 Superficial injury of hip and thigh
0.764 0.236 0.000
J93 Pneumothorax
0.764 0.236 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.763 0.237 0.000
W06 Fall involving bed
0.762 0.238 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.762 0.238 0.000
A00-A09 Intestinal infectious diseases
0.762 0.238 0.000
D70 Agranulocytosis
0.762 0.238 0.000
V20-V29 Motorcycle rider injured in transport accident
0.761 0.239 0.000
K76.9 Liver disease, unspecified
0.761 0.239 0.000
K04.7 Periapical abscess without sinus
0.760 0.240 0.000
M20.1 Hallux valgus (acquired)
0.760 0.240 0.000
J91 Pleural effusion in conditions classified elsewhere
0.758 0.242 0.000
W02 Fall involving ice-skates, skis, roller-skates or skateboards
0.758 0.242 0.000
O36.8 Maternal care for other specified foetal problems
0.757 0.243 0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.755 0.245 0.000
E11.4 With neurological complications
0.754 0.246 0.000
O44 Placenta praevia
0.753 0.247 0.000
M11.2 Other chondrocalcinosis
0.753 0.247 0.000
K76.0 Fatty (change of) liver, not elsewhere classified
0.753 0.247 0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.752 0.248 0.000
K11 Diseases of salivary glands
0.751 0.249 0.000
C32 Malignant neoplasm of larynx
0.750 0.250 0.000
E83.4 Disorders of magnesium metabolism
0.749 0.251 0.000
L02.3 Cutaneous abscess, furuncle and carbuncle of buttock
0.749 0.251 0.000
I38 Endocarditis, valve unspecified
0.749 0.251 0.000
I50.9 Heart failure, unspecified
0.748 0.252 0.000
L08.9 Local infection of skin and subcutaneous tissue, unspecified
0.747 0.253 0.000
S81 Open wound of lower leg
0.746 0.254 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.746 0.254 0.000
G51 Facial nerve disorders
0.745 0.255 0.000
K01 Embedded and impacted teeth
0.745 0.255 0.000
B15-B19 Viral hepatitis
0.745 0.255 0.000
B37.8 Candidiasis of other sites
0.745 0.255 0.000
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs
0.744 0.256 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.744 0.256 0.000
C79.2 Secondary malignant neoplasm of skin
0.743 0.256 0.000
O16 Unspecified maternal hypertension
0.743 0.257 0.000
E10.5 With peripheral circulatory complications
0.743 0.257 0.000
K09 Cysts of oral region, not elsewhere classified
0.743 0.257 0.000
M84.1 Nonunion of fracture [pseudarthrosis]
0.742 0.258 0.000
K06 Other disorders of gingiva and edentulous alveolar ridge
0.742 0.258 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.741 0.259 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.741 0.259 0.000
Y45.0 Opioids and related analgesics
0.740 0.260 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.739 0.261 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.739 0.261 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
0.739 0.261 0.000
C71 Malignant neoplasm of brain
0.739 0.261 0.000
K02 Dental caries
0.738 0.262 0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs
0.738 0.262 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.738 0.262 0.000
H55-H59 Other disorders of eye and adnexa
0.737 0.263 0.000
K90-K93 Other diseases of the digestive system
0.737 0.263 0.000
V10-V19 Pedal cyclist injured in transport accident
0.736 0.263 0.000
J00-J06 Acute upper respiratory infections
0.736 0.264 0.000
O34 Maternal care for known or suspected abnormality of pelvic organs
0.736 0.264 0.000
Q80-Q89 Other congenital malformations
0.735 0.265 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.735 0.265 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.735 0.265 0.000
K04.6 Periapical abscess with sinus
0.734 0.266 0.000
L03.8 Cellulitis of other sites
0.733 0.267 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.733 0.267 0.000
K70.1 Alcoholic hepatitis
0.733 0.267 0.000
W07 Fall involving chair
0.733 0.267 0.000
K07.6 Temporomandibular joint disorders
0.733 0.267 0.000
G90 Disorders of autonomic nervous system
0.732 0.268 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.732 0.268 0.000
L72 Follicular cysts of skin and subcutaneous tissue
0.731 0.269 0.000
K75.8 Other specified inflammatory liver diseases
0.731 0.269 0.000
K65 Peritonitis
0.731 0.269 0.000
O47.1 False labour at or after 37 completed weeks of gestation
0.730 0.270 0.000
J94 Other pleural conditions
0.729 0.270 0.000
M00-M03 Infectious arthropathies
0.729 0.271 0.000
I89 Other non-infective disorders of lymphatic vessels and lymph nodes
0.729 0.271 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.728 0.272 0.000
M24 Other specific joint derangements
0.728 0.272 0.000
E11.5 With peripheral circulatory complications
0.727 0.273 0.000
E10.2 With renal complications
0.727 0.273 0.000
I47 Paroxysmal tachycardia
0.727 0.273 0.000
M05 Seropositive rheumatoid arthritis
0.727 0.273 0.000
O60-O75 Complications of labour and delivery
0.726 0.274 0.000
L02.2 Cutaneous abscess, furuncle and carbuncle of trunk
0.726 0.274 0.000
Q50-Q56 Congenital malformations of genital organs
0.725 0.275 0.000
I12.9 Hypertensive renal disease without renal failure
0.724 0.276 0.000
V80-V89 Other land transport accidents
0.724 0.276 0.000
O36.5 Maternal care for poor foetal growth
0.723 0.277 0.000
I86 Varicose veins of other sites
0.723 0.277 0.000
E11.2 With renal complications
0.723 0.277 0.000
M79.1 Myalgia
0.721 0.278 0.000
C79.9 Secondary malignant neoplasm, unspecified site
0.721 0.279 0.000
M25.47 Effusion of joint (Ankle and foot)
0.721 0.279 0.000
J30 Vasomotor and allergic rhinitis
0.720 0.280 0.000
E83.5 Disorders of calcium metabolism
0.720 0.280 0.000
M34 Systemic sclerosis
0.719 0.281 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.719 0.281 0.000
E83.1 Disorders of iron metabolism
0.719 0.281 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.719 0.281 0.000
D63 Anaemia in chronic diseases classified elsewhere
0.718 0.282 0.000
M23.32 Other meniscus derangements (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.718 0.282 0.000
H72 Perforation of tympanic membrane
0.717 0.283 0.000
J38 Diseases of vocal cords and larynx, not elsewhere classified
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
M60-M63 Disorders of muscles
0.717 0.283 0.000
G95 Other diseases of spinal cord
0.717 0.283 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.716 0.284 0.000
Y35-Y36 Legal intervention and operations of war
0.715 0.284 0.000
Y10-Y34 Event of undetermined intent
0.715 0.284 0.000
Y00-Y09 Assault
0.715 0.284 0.000
X85-X99 Assault
0.715 0.284 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.715 0.284 0.000
X50-X57 Overexertion, travel and privation
0.715 0.284 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.715 0.284 0.000
X30-X39 Exposure to forces of nature
0.715 0.284 0.000
X20-X29 Contact with venomous animals and plants
0.715 0.284 0.000
X10-X19 Contact with heat and hot substances
0.715 0.284 0.000
X00-X09 Exposure to smoke, fire and flames
0.715 0.284 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.715 0.284 0.000
W75-W84 Other accidental threats to breathing
0.715 0.284 0.000
W65-W74 Accidental drowning and submersion
0.715 0.284 0.000
W50-W64 Exposure to animate mechanical forces
0.715 0.284 0.000
V98-V99 Other and unspecified transport accidents
0.715 0.284 0.000
V95-V97 Air and space transport accidents
0.715 0.284 0.000
V90-V94 Water transport accidents
0.715 0.284 0.000
V70-V79 Bus occupant injured in transport accident
0.715 0.284 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.715 0.284 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.715 0.284 0.000
V40-V49 Car occupant injured in transport accident
0.715 0.284 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.715 0.284 0.000
V01-V09 Pedestrian injured in transport accident
0.715 0.284 0.000
M14 Arthropathies in other diseases classified elsewhere
0.715 0.285 0.000
M12 Other specific arthropathies
0.715 0.285 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.715 0.285 0.000
M08 Juvenile arthritis
0.715 0.285 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.715 0.285 0.000
M33 Dermatopolymyositis
0.715 0.285 0.000
M32 Systemic lupus erythematosus
0.715 0.285 0.000
M30 Polyarteritis nodosa and related conditions
0.715 0.285 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.715 0.285 0.000
L10-L14 Bullous disorders
0.714 0.285 0.000
K77 Liver disorders in diseases classified elsewhere
0.714 0.285 0.000
K71 Toxic liver disease
0.714 0.285 0.000
K03 Other diseases of hard tissues of teeth
0.714 0.285 0.000
K00 Disorders of tooth development and eruption
0.714 0.285 0.000
C39 Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs
0.714 0.286 0.000
C38 Malignant neoplasm of heart, mediastinum and pleura
0.714 0.286 0.000
C31 Malignant neoplasm of accessory sinuses
0.714 0.286 0.000
C30 Malignant neoplasm of nasal cavity and middle ear
0.714 0.286 0.000
C37 Malignant neoplasm of thymus
0.714 0.286 0.000
C33 Malignant neoplasm of trachea
0.714 0.286 0.000
O85-O92 Complications predominantly related to the puerperium
0.714 0.286 0.000
M06.8 Other specified rheumatoid arthritis
0.714 0.286 0.000
M06.4 Inflammatory polyarthropathy
0.714 0.286 0.000
M06.3 Rheumatoid nodule
0.714 0.286 0.000
M06.2 Rheumatoid bursitis
0.714 0.286 0.000
M06.1 Adult-onset Still's disease
0.714 0.286 0.000
M65-M68 Disorders of synovium and tendon
0.714 0.286 0.000
I00-I02 Acute rheumatic fever
0.713 0.287 0.000
S30.1 Contusion of abdominal wall
0.713 0.287 0.000
M79.7 Fibromyalgia
0.713 0.287 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.713 0.287 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.713 0.287 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.713 0.287 0.000
C34.8 Overlapping lesion of bronchus and lung
0.713 0.287 0.000
C34.2 Middle lobe, bronchus or lung
0.713 0.287 0.000
T33-T35 Frostbite
0.712 0.288 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.712 0.288 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.712 0.288 0.000
T00-T07 Injuries involving multiple body regions
0.712 0.288 0.000
O45 Premature separation of placenta [abruptio placentae]
0.712 0.288 0.000
O35 Maternal care for known or suspected foetal abnormality and damage
0.712 0.288 0.000
O33 Maternal care for known or suspected disproportion
0.712 0.288 0.000
O31 Complications specific to multiple gestation
0.712 0.288 0.000
O40 Polyhydramnios
0.712 0.288 0.000
I60-I69 Cerebrovascular diseases
0.712 0.288 0.000
L04 Acute lymphadenitis
0.711 0.288 0.000
L01 Impetigo
0.711 0.288 0.000
L00 Staphylococcal scalded skin syndrome
0.711 0.288 0.000
S20-S29 Injuries to the thorax
0.711 0.289 0.000
T79-T79 Certain early complications of trauma
0.711 0.289 0.000
S40-S49 Injuries to the shoulder and upper arm
0.711 0.289 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.710 0.290 0.000
C76 Malignant neoplasm of other and ill-defined sites
0.710 0.290 0.000
H53-H54 Visual disturbances and blindness
0.710 0.290 0.000
M91-M94 Chondropathies
0.709 0.290 0.000
K08.9 Disorder of teeth and supporting structures, unspecified
0.709 0.291 0.000
K08.2 Atrophy of edentulous alveolar ridge
0.709 0.291 0.000
K08.0 Exfoliation of teeth due to systemic causes
0.709 0.291 0.000
I49.3 Ventricular premature depolarisation
0.709 0.291 0.000
Y51.7 Beta-Adrenoreceptor antagonists, not elsewhere classified
0.709 0.291 0.000
D55-D59 Haemolytic anaemias
0.709 0.291 0.000
Q61.3 Polycystic kidney, unspecified
0.708 0.291 0.000
Y45.1 Salicylates
0.708 0.292 0.000
T68 Hypothermia
0.708 0.292 0.000
M80 Osteoporosis with pathological fracture
0.708 0.292 0.000
X60-X84 Intentional self-harm
0.707 0.293 0.000
E40-E46 Malnutrition
0.707 0.293 0.000
S62 Fracture at wrist and hand level
0.707 0.293 0.000
C79.6 Secondary malignant neoplasm of ovary
0.706 0.294 0.000
C79.4 Secondary malignant neoplasm of other and unspecified parts of nervous system
0.706 0.294 0.000
C79.1 Secondary malignant neoplasm of bladder and other and unspecified urinary organs
0.706 0.294 0.000
C79.0 Secondary malignant neoplasm of kidney and renal pelvis
0.706 0.294 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.705 0.294 0.000
W18 Other fall on same level
0.705 0.295 0.000
W17 Other fall from one level to another
0.705 0.295 0.000
W16 Diving or jumping into water causing injury other than drowning or submersion
0.705 0.295 0.000
W15 Fall from cliff
0.705 0.295 0.000
W14 Fall from tree
0.705 0.295 0.000
W12 Fall on and from scaffolding
0.705 0.295 0.000
W09 Fall involving playground equipment
0.705 0.295 0.000
W08 Fall involving other furniture
0.705 0.295 0.000
W05 Fall involving wheelchair
0.705 0.295 0.000
W04 Fall while being carried or supported by other persons
0.705 0.295 0.000
W03 Other fall on same level due to collision with, or pushing by, another person
0.705 0.295 0.000
W01 Fall on same level from slipping, tripping and stumbling
0.705 0.295 0.000
W00 Fall on same level involving ice and snow
0.705 0.295 0.000
S79 Other and unspecified injuries of hip and thigh
0.705 0.295 0.000
I51 Complications and ill-defined descriptions of heart disease
0.705 0.295 0.000
T93 Sequelae of injuries of lower limb
0.704 0.296 0.000
B99-B99 Other infectious diseases
0.704 0.296 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.704 0.296 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.704 0.296 0.000
B65-B83 Helminthiases
0.704 0.296 0.000
B50-B64 Protozoal diseases
0.704 0.296 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.704 0.296 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.704 0.296 0.000
A75-A79 Rickettsioses
0.704 0.296 0.000
A70-A74 Other diseases caused by chlamydiae
0.704 0.296 0.000
A65-A69 Other spirochaetal diseases
0.704 0.296 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.704 0.296 0.000
A20-A28 Certain zoonotic bacterial diseases
0.704 0.296 0.000
A15-A19 Tuberculosis
0.704 0.296 0.000
Y59 Other and unspecified vaccines and biological substances
0.703 0.297 0.000
Y58 Bacterial vaccines
0.703 0.297 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.703 0.297 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.703 0.297 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.703 0.297 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.703 0.297 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.703 0.297 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.703 0.297 0.000
Y48 Anaesthetics and therapeutic gases
0.703 0.297 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.703 0.297 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.703 0.297 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.703 0.297 0.000
I15 Secondary hypertension
0.703 0.297 0.000
I13 Hypertensive heart and renal disease
0.703 0.297 0.000
T78 Adverse effects, not elsewhere classified
0.700 0.300 0.000
M23.8 Other internal derangements of knee
0.699 0.301 0.000
L03.9 Cellulitis, unspecified
0.699 0.301 0.000
L02.9 Cutaneous abscess, furuncle and carbuncle, unspecified
0.698 0.301 0.000
L02.8 Cutaneous abscess, furuncle and carbuncle of other sites
0.698 0.301 0.000
L02.0 Cutaneous abscess, furuncle and carbuncle of face
0.698 0.301 0.000
S30.0 Contusion of lower back and pelvis
0.698 0.302 0.000
E13 Other specified diabetes mellitus
0.698 0.302 0.000
M25.9 Joint disorder, unspecified
0.697 0.303 0.000
M21.0 Valgus deformity, not elsewhere classified
0.697 0.303 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.696 0.304 0.000
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.696 0.304 0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee
0.696 0.304 0.000
E87.7 Fluid overload
0.695 0.305 0.000
K74.0 Hepatic fibrosis
0.695 0.305 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.693 0.306 0.000
S71 Open wound of hip and thigh
0.693 0.307 0.000
M79.80 Other specified soft tissue disorders (Multiple sites)
0.693 0.307 0.000
O32.3 Maternal care for face, brow and chin presentation
0.693 0.307 0.000
E12 Malnutrition-related diabetes mellitus
0.692 0.308 0.000
C80.0 Malignant neoplasm, primary site unknown, so stated
0.692 0.308 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.691 0.309 0.000
I05-I09 Chronic rheumatic heart diseases
0.691 0.309 0.000
Y52.2 Other antidysrhythmic drugs, not elsewhere classified
0.691 0.309 0.000
I85.0 Oesophageal varices with bleeding
0.690 0.310 0.000
Q61.2 Polycystic kidney, adult type
0.690 0.310 0.000
U80.1 Methicillin resistant agent
0.690 0.310 0.000
U81 Agent resistant to vancomycin and related antibiotics
0.690 0.310 0.000
M21.1 Varus deformity, not elsewhere classified
0.689 0.310 0.000
K13.0 Diseases of lips
0.689 0.311 0.000
B44 Aspergillosis
0.688 0.312 0.000
W11.6 Industrial and construction area
0.688 0.312 0.000
W19.8 Other specified place
0.687 0.313 0.000
W19.5 Trade and service area
0.687 0.313 0.000
W19.0 Home
0.687 0.313 0.000
W19.7 Farm
0.687 0.313 0.000
W19.6 Industrial and construction area
0.687 0.313 0.000
W19.3 Sports and athletics area
0.687 0.313 0.000
W19.1 Residential institution
0.687 0.313 0.000
G70-G73 Diseases of myoneural junction and muscle
0.686 0.314 0.000
I87 Other disorders of veins
0.686 0.314 0.000
I81 Portal vein thrombosis
0.686 0.314 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.685 0.315 0.000
M22.0 Recurrent dislocation of patella
0.685 0.315 0.000
O32.0 Maternal care for unstable lie
0.684 0.316 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.684 0.316 0.000
C90 Multiple myeloma and malignant plasma cell neoplasms
0.684 0.316 0.000
T90 Sequelae of injuries of head
0.683 0.317 0.000
B25-B34 Other viral diseases
0.683 0.317 0.000
Q00-Q07 Congenital malformations of the nervous system
0.682 0.317 0.000
E10.9 Without complications
0.682 0.318 0.000
L03.3 Cellulitis of trunk
0.682 0.318 0.000
U80.0 Penicillin resistant agent
0.682 0.318 0.000
B35 Dermatophytosis
0.682 0.318 0.000
I11.9 Hypertensive heart disease without (congestive) heart failure
0.681 0.319 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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