TreeWAS – Variant ID: rs79481790

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability
# Top node	1.000	0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes	1.000	0.000
Chapter II Neoplasms	0.999	0.001
Chapter IV Endocrine, nutritional and metabolic diseases	0.996	0.004
Chapter V Mental and behavioural disorders	0.995	0.005
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites	0.986	0.014
E10-E14 Diabetes mellitus	0.985	0.015
C64-C68 Malignant neoplasms of urinary tract	0.979	0.021
D00-D09 In situ neoplasms	0.979	0.021
C67 Malignant neoplasm of bladder	0.972	0.028
Chapter XX External causes of morbidity and mortality	0.971	0.029
C79 Secondary malignant neoplasm of other sites	0.969	0.031
E20-E35 Disorders of other endocrine glands	0.968	0.032
S90-S99 Injuries to the ankle and foot	0.967	0.033
D04 Carcinoma in situ of skin	0.966	0.034
S80-S89 Injuries to the knee and lower leg	0.965	0.035
C79.5 Secondary malignant neoplasm of bone and bone marrow	0.963	0.037
S50-S59 Injuries to the elbow and forearm	0.958	0.042
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx	0.953	0.047
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.951	0.049
F30-F39 Mood [affective] disorders	0.950	0.050
T93 Sequelae of injuries of lower limb	0.943	0.057
S82 Fracture of lower leg, including ankle	0.937	0.063
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.935	0.065
E11 Non-insulin-dependent diabetes mellitus	0.934	0.066
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors	0.934	0.066
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.931	0.069
C77 Secondary and unspecified malignant neoplasm of lymph nodes	0.926	0.074
D04.3 Skin of other and unspecified parts of face	0.926	0.074
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.926	0.074
T80-T88 Complications of surgical and medical care, not elsewhere classified	0.922	0.078
F40-F48 Neurotic, stress-related and somatoform disorders	0.921	0.079
C67.9 Bladder, unspecified	0.917	0.083
Y85-Y89 Sequelae of external causes of morbidity and mortality	0.915	0.085
S51 Open wound of forearm	0.913	0.087
M80-M85 Disorders of bone density and structure	0.912	0.088
F33 Recurrent depressive disorder	0.910	0.090
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.909	0.091
E14 Unspecified diabetes mellitus	0.905	0.095
T93.2 Sequelae of other fractures of lower limb	0.903	0.097
S82.8 Fractures of other parts of lower leg	0.901	0.099
D80-D89 Certain disorders involving the immune mechanism	0.898	0.102
F60-F69 Disorders of adult personality and behaviour	0.890	0.110
D86 Sarcoidosis	0.887	0.113
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.887	0.113
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts	0.886	0.114
M81 Osteoporosis without pathological fracture	0.886	0.114
S82.80 Fractures of other parts of lower leg (closed)	0.881	0.119
Chapter VI Diseases of the nervous system	0.879	0.121
M86-M90 Other osteopathies	0.878	0.122
E27 Other disorders of adrenal gland	0.878	0.122
T20-T25 Burns and corrosions of external body surface, specified by site	0.876	0.124
C77.9 Lymph node, unspecified	0.871	0.129
E11.3 With ophthalmic complications	0.863	0.137
T86 Failure and rejection of transplanted organs and tissues	0.863	0.137
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system	0.859	0.141
S92 Fracture of foot, except ankle	0.859	0.141
T93.3 Sequelae of dislocation, sprain and strain of lower limb	0.858	0.142
C67.2 Lateral wall of bladder	0.856	0.144
C67.1 Dome of bladder	0.856	0.144
S90 Superficial injury of ankle and foot	0.855	0.145
S80 Superficial injury of lower leg	0.854	0.146
M84 Disorders of continuity of bone	0.854	0.146
M81.9 Osteoporosis, unspecified	0.852	0.148
W00-W19 Falls	0.851	0.149
Y86 Sequelae of other accidents	0.849	0.151
C79.9 Secondary malignant neoplasm, unspecified site	0.848	0.152
F33.2 Recurrent depressive disorder, current episode severe without psychotic symptoms	0.844	0.156
C79.0 Secondary malignant neoplasm of kidney and renal pelvis	0.844	0.156
C02 Malignant neoplasm of other and unspecified parts of tongue	0.843	0.157
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.841	0.159
F52 Sexual dysfunction, not caused by organic disorder or disease	0.839	0.161
E40-E46 Malnutrition	0.838	0.162
E21.0 Primary hyperparathyroidism	0.837	0.163
D86.9 Sarcoidosis, unspecified	0.836	0.164
C77.2 Intra-abdominal lymph nodes	0.834	0.166
M81.99 Osteoporosis, unspecified (Site unspecified)	0.833	0.167
D37-D48 Neoplasms of uncertain or unknown behaviour	0.833	0.167
S51.0 Open wound of elbow	0.832	0.168
T86.1 Kidney transplant failure and rejection	0.831	0.169
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure	0.826	0.174
M20-M25 Other joint disorders	0.826	0.174
S10-S19 Injuries to the neck	0.826	0.174
G30-G32 Other degenerative diseases of the nervous system	0.825	0.175
F33.3 Recurrent depressive disorder, current episode severe with psychotic symptoms	0.823	0.177
T36-T50 Poisoning by drugs, medicaments and biological substances	0.820	0.180
E10 Insulin-dependent diabetes mellitus	0.819	0.181
T00-T07 Injuries involving multiple body regions	0.816	0.184
M25 Other joint disorders, not elsewhere classified	0.816	0.184
S82.2 Fracture of shaft of tibia	0.815	0.185
F50 Eating disorders	0.812	0.188
S51.9 Open wound of forearm, part unspecified	0.811	0.189
F34 Persistent mood [affective] disorders	0.811	0.189
M05-M14 Inflammatory polyarthropathies	0.809	0.191
C01 Malignant neoplasm of base of tongue	0.809	0.191
F60 Specific personality disorders	0.809	0.191
M84.1 Nonunion of fracture [pseudarthrosis]	0.806	0.194
F99-F99 Unspecified mental disorder	0.803	0.197
D04.2 Skin of ear and external auricular canal	0.800	0.200
E11.9 Without complications	0.799	0.201
D04.6 Skin of upper limb, including shoulder	0.798	0.202
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.796	0.204
D04.4 Skin of scalp and neck	0.796	0.204
E27.8 Other specified disorders of adrenal gland	0.796	0.204
T93.8 Sequelae of other specified injuries of lower limb	0.794	0.206
X60-X84 Intentional self-harm	0.793	0.207
F44 Dissociative [conversion] disorders	0.793	0.207
M25.5 Pain in joint	0.791	0.209
D02 Carcinoma in situ of middle ear and respiratory system	0.791	0.209
M25.8 Other specified joint disorders	0.786	0.214
F32 Depressive episode	0.785	0.215
T79-T79 Certain early complications of trauma	0.783	0.217
M25.51 Pain in joint (Shoulder region)	0.783	0.217
D86.0 Sarcoidosis of lung	0.782	0.218
S91 Open wound of ankle and foot	0.781	0.219
T09 Other injuries of spine and trunk, level unspecified	0.780	0.220
E14.9 Without complications	0.779	0.221
W75-W84 Other accidental threats to breathing	0.778	0.222
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.777	0.223
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level	0.775	0.225
T82.1 Mechanical complication of cardiac electronic device	0.774	0.226
T66-T78 Other and unspecified effects of external causes	0.773	0.227
G40-G47 Episodic and paroxysmal disorders	0.773	0.227
Q50-Q56 Congenital malformations of genital organs	0.772	0.228
Q60-Q64 Congenital malformations of the urinary system	0.771	0.229
E11.5 With peripheral circulatory complications	0.771	0.229
F52.2 Failure of genital response	0.771	0.229
S92.0 Fracture of calcaneus	0.769	0.231
T82.2 Mechanical complication of coronary artery bypass and valve grafts	0.768	0.232
Q20-Q28 Congenital malformations of the circulatory system	0.768	0.232
E14.8 With unspecified complications	0.768	0.232
M25.87 Other specified joint disorders (Ankle and foot)	0.767	0.233
C67.4 Posterior wall of bladder	0.767	0.233
E21.4 Other specified disorders of parathyroid gland	0.766	0.234
F00-F09 Organic, including symptomatic, mental disorders	0.766	0.234
M89 Other disorders of bone	0.765	0.235
C79.1 Secondary malignant neoplasm of bladder and other and unspecified urinary organs	0.764	0.236
X40-X49 Accidental poisoning by and exposure to noxious substances	0.762	0.238
C00 Malignant neoplasm of lip	0.762	0.238
M84.17 Nonunion of fracture [pseudarthrosis] (Ankle and foot)	0.760	0.240
X58-X59 Accidental exposure to other and unspecified factors	0.760	0.240
C40-C41 Malignant neoplasms of bone and articular cartilage	0.760	0.240
V01-V09 Pedestrian injured in transport accident	0.760	0.240
D03 Melanoma in situ	0.759	0.241
S56 Injury of muscle and tendon at forearm level	0.758	0.242
E21.1 Secondary hyperparathyroidism, not elsewhere classified	0.756	0.244
Q80-Q89 Other congenital malformations	0.756	0.244
T85 Complications of other internal prosthetic devices, implants and grafts	0.754	0.246
C67.6 Ureteric orifice	0.754	0.246
D04.5 Skin of trunk	0.754	0.246
S82.21 Fracture of shaft of tibia (open)	0.754	0.246
E10.5 With peripheral circulatory complications	0.752	0.248
T93.9 Sequelae of unspecified injury of lower limb	0.749	0.250
Y85 Sequelae of transport accidents	0.749	0.251
C77.5 Intrapelvic lymph nodes	0.749	0.251
D80 Immunodeficiency with predominantly antibody defects	0.747	0.253
C10 Malignant neoplasm of oropharynx	0.746	0.254
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites	0.746	0.254
D86.3 Sarcoidosis of skin	0.745	0.255
E27.4 Other and unspecified adrenocortical insufficiency	0.745	0.255
V80-V89 Other land transport accidents	0.745	0.255
G31 Other degenerative diseases of nervous system, not elsewhere classified	0.744	0.256
F45 Somatoform disorders	0.742	0.258
F33.1 Recurrent depressive disorder, current episode moderate	0.740	0.260
C80 Malignant neoplasm without specification of site	0.740	0.260
M07 Psoriatic and enteropathic arthropathies	0.739	0.261
S53 Dislocation, sprain and strain of joints and ligaments of elbow	0.738	0.261
T80 Complications following infusion, transfusion and therapeutic injection	0.738	0.262
G80-G83 Cerebral palsy and other paralytic syndromes	0.737	0.263
S90.9 Superficial injury of ankle and foot, unspecified	0.737	0.263
T82.4 Mechanical complication of vascular dialysis catheter	0.737	0.263
S80.9 Superficial injury of lower leg, unspecified	0.736	0.264
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.735	0.265
M87 Osteonecrosis	0.734	0.266
Y84 Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure	0.734	0.266
E20 Hypoparathyroidism	0.733	0.267
F40 Phobic anxiety disorders	0.733	0.267
S59 Other and unspecified injuries of forearm	0.733	0.267
W13 Fall from, out of or through building or structure	0.729	0.271
E11.6 With other specified complications	0.729	0.271
C67.3 Anterior wall of bladder	0.728	0.272
G45 Transient cerebral ischaemic attacks and related syndromes	0.727	0.273
S50 Superficial injury of forearm	0.726	0.274
C02.9 Tongue, unspecified	0.726	0.274
M88 Paget's disease of bone [osteitis deformans]	0.725	0.275
S86 Injury of muscle and tendon at lower leg level	0.725	0.275
S54 Injury of nerves at forearm level	0.724	0.276
E46 Unspecified protein-energy malnutrition	0.724	0.276
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use	0.723	0.277
S92.3 Fracture of metatarsal bone	0.723	0.277
E13 Other specified diabetes mellitus	0.722	0.277
W02 Fall involving ice-skates, skis, roller-skates or skateboards	0.722	0.278
C67.0 Trigone of bladder	0.721	0.279
S51.7 Multiple open wounds of forearm	0.720	0.280
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts	0.720	0.280
Y88 Sequelae of surgical and medical care as external cause	0.720	0.280
E00-E07 Disorders of thyroid gland	0.720	0.280
C11 Malignant neoplasm of nasopharynx	0.719	0.281
M91-M94 Chondropathies	0.719	0.281
C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx	0.718	0.282
Chapter XVI Certain conditions originating in the perinatal period	0.717	0.283
T33-T35 Frostbite	0.717	0.283
T26-T28 Burns and corrosions confined to eye and internal organs	0.717	0.283
S10 Superficial injury of neck	0.717	0.283
D07 Carcinoma in situ of other and unspecified genital organs	0.716	0.284
C71 Malignant neoplasm of brain	0.716	0.284
D09 Carcinoma in situ of other and unspecified sites	0.716	0.284
G30 Alzheimer's disease	0.716	0.284
S82.3 Fracture of lower end of tibia	0.716	0.284
T82.9 Unspecified complication of cardiac and vascular prosthetic device, implant and graft	0.715	0.285
C15-C26 Malignant neoplasms of digestive organs	0.714	0.286
X20-X29 Contact with venomous animals and plants	0.714	0.286
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence	0.713	0.287
F70-F79 Mental retardation	0.713	0.287
G45.9 Transient cerebral ischaemic attack, unspecified	0.712	0.288
F34.1 Dysthymia	0.711	0.289
T24 Burn and corrosion of hip and lower limb, except ankle and foot	0.711	0.289
C04 Malignant neoplasm of floor of mouth	0.710	0.290
E23 Hypofunction and other disorders of pituitary gland	0.709	0.291
W50-W64 Exposure to animate mechanical forces	0.708	0.291
C79.7 Secondary malignant neoplasm of adrenal gland	0.708	0.292
C66 Malignant neoplasm of ureter	0.708	0.292
F60.9 Personality disorder, unspecified	0.707	0.293
C76 Malignant neoplasm of other and ill-defined sites	0.707	0.293
V10-V19 Pedal cyclist injured in transport accident	0.707	0.293
E28 Ovarian dysfunction	0.706	0.294
D86.1 Sarcoidosis of lymph nodes	0.706	0.294
E12 Malnutrition-related diabetes mellitus	0.706	0.294
T20 Burn and corrosion of head and neck	0.706	0.294
S82.4 Fracture of fibula alone	0.706	0.294
T46 Poisoning by agents primarily affecting the cardiovascular system	0.705	0.295
S82.5 Fracture of medial malleolus	0.704	0.296
S92.00 Fracture of calcaneus (closed)	0.704	0.296
T09.0 Superficial injury of trunk, level unspecified	0.704	0.296
T93.5 Sequelae of injury of muscle and tendon of lower limb	0.704	0.296
E11.8 With unspecified complications	0.703	0.297
M25.56 Pain in joint (Lower leg)	0.702	0.298
C68 Malignant neoplasm of other and unspecified urinary organs	0.702	0.298
W17 Other fall from one level to another	0.702	0.298
D01 Carcinoma in situ of other and unspecified digestive organs	0.702	0.298
D00 Carcinoma in situ of oral cavity, oesophagus and stomach	0.702	0.298
Chapter XII Diseases of the skin and subcutaneous tissue	0.702	0.298
X50-X57 Overexertion, travel and privation	0.700	0.300
T00 Superficial injuries involving multiple body regions	0.699	0.301
M81.98 Osteoporosis, unspecified (Other)	0.699	0.301
C67.8 Overlapping lesion of bladder	0.697	0.303
C67.7 Urachus	0.697	0.303
Y35-Y36 Legal intervention and operations of war	0.696	0.304
Y10-Y34 Event of undetermined intent	0.696	0.304
X85-X99 Assault	0.696	0.304
X30-X39 Exposure to forces of nature	0.696	0.304
X00-X09 Exposure to smoke, fire and flames	0.696	0.304
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure	0.696	0.304
W65-W74 Accidental drowning and submersion	0.696	0.304
V98-V99 Other and unspecified transport accidents	0.696	0.304
V95-V97 Air and space transport accidents	0.696	0.304
V90-V94 Water transport accidents	0.696	0.304
V70-V79 Bus occupant injured in transport accident	0.696	0.304
V60-V69 Occupant of heavy transport vehicle injured in transport accident	0.696	0.304
V50-V59 Occupant of pick-up truck or van injured in transport accident	0.696	0.304
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident	0.696	0.304
M81.2 Osteoporosis of disuse	0.696	0.304
T82.0 Mechanical complication of heart valve prosthesis	0.696	0.304
M81.4 Drug-induced osteoporosis	0.695	0.305
E35 Disorders of endocrine glands in diseases classified elsewhere	0.694	0.306
E32 Diseases of thymus	0.694	0.306
E31 Polyglandular dysfunction	0.694	0.306
E30 Disorders of puberty, not elsewhere classified	0.694	0.306
E25 Adrenogenital disorders	0.694	0.306
S31 Open wound of abdomen, lower back and pelvis	0.694	0.306
S98 Traumatic amputation of ankle and foot	0.694	0.306
S97 Crushing injury of ankle and foot	0.694	0.306
S96 Injury of muscle and tendon at ankle and foot level	0.694	0.306
S95 Injury of blood vessels at ankle and foot level	0.694	0.306
S94 Injury of nerves at ankle and foot level	0.694	0.306
E21.3 Hyperparathyroidism, unspecified	0.693	0.307
V40-V49 Car occupant injured in transport accident	0.693	0.307
D04.9 Skin, unspecified	0.693	0.307
D04.8 Skin of other sites	0.693	0.307
D04.1 Skin of eyelid, including canthus	0.693	0.307
D04.0 Skin of lip	0.693	0.307
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.692	0.308
S88 Traumatic amputation of lower leg	0.692	0.308
S87 Crushing injury of lower leg	0.692	0.308
S85 Injury of blood vessels at lower leg level	0.692	0.308
S84 Injury of nerves at lower leg level	0.692	0.308
F44.9 Dissociative [conversion] disorder, unspecified	0.690	0.310
S90.8 Other superficial injuries of ankle and foot	0.689	0.310
C69 Malignant neoplasm of eye and adnexa	0.689	0.311
M07.3 Other psoriatic arthropathies	0.689	0.311
T98 Sequelae of other and unspecified effects of external causes	0.688	0.311
S82.0 Fracture of patella	0.688	0.312
E14.3 With ophthalmic complications	0.688	0.312
M33 Dermatopolymyositis	0.688	0.312
F33.0 Recurrent depressive disorder, current episode mild	0.687	0.313
S58 Traumatic amputation of forearm	0.687	0.313
S57 Crushing injury of forearm	0.687	0.313
S55 Injury of blood vessels at forearm level	0.687	0.313
C67.5 Bladder neck	0.687	0.313
S32 Fracture of lumbar spine and pelvis	0.686	0.314
M24 Other specific joint derangements	0.686	0.314
T85.5 Mechanical complication of gastro-intestinal prosthetic devices, implants and grafts	0.686	0.314
G31.9 Degenerative disease of nervous system, unspecified	0.685	0.315
T87 Complications peculiar to reattachment and amputation	0.685	0.315
E26 Hyperaldosteronism	0.684	0.316
C13 Malignant neoplasm of hypopharynx	0.683	0.316
C08 Malignant neoplasm of other and unspecified major salivary glands	0.683	0.316
C06 Malignant neoplasm of other and unspecified parts of mouth	0.683	0.316
C05 Malignant neoplasm of palate	0.683	0.316
C03 Malignant neoplasm of gum	0.683	0.316
C12 Malignant neoplasm of pyriform sinus	0.683	0.316
Q00-Q07 Congenital malformations of the nervous system	0.683	0.317
M89.9 Disorder of bone, unspecified	0.683	0.317
T13 Other injuries of lower limb, level unspecified	0.683	0.317
T95 Sequelae of burns, corrosions and frostbite	0.682	0.318
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source	0.682	0.318
T96 Sequelae of poisoning by drugs, medicaments and biological substances	0.682	0.318
C79.2 Secondary malignant neoplasm of skin	0.682	0.318
C02.1 Border of tongue	0.681	0.319
F38 Other mood [affective] disorders	0.681	0.319
F39 Unspecified mood [affective] disorder	0.681	0.319
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.680	0.320
E29 Testicular dysfunction	0.679	0.321
X10-X19 Contact with heat and hot substances	0.679	0.321
C45-C49 Malignant neoplasms of mesothelial and soft tissue	0.679	0.321
F43 Reaction to severe stress, and adjustment disorders	0.679	0.321
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system	0.678	0.322
M00-M03 Infectious arthropathies	0.678	0.322
T94 Sequelae of injuries involving multiple and unspecified body regions	0.678	0.322
F60.3 Emotionally unstable personality disorder	0.678	0.322
F30 Manic episode	0.677	0.323
F42 Obsessive-compulsive disorder	0.676	0.324
T93.6 Sequelae of crushing injury and traumatic amputation of lower limb	0.676	0.324
T93.4 Sequelae of injury of nerve of lower limb	0.676	0.324
C18 Malignant neoplasm of colon	0.676	0.324
M84.13 Nonunion of fracture [pseudarthrosis] (Forearm)	0.676	0.324
D48.6 Breast	0.676	0.324
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs	0.676	0.324
F41 Other anxiety disorders	0.676	0.324
F32.3 Severe depressive episode with psychotic symptoms	0.675	0.325
E34 Other endocrine disorders	0.675	0.325
S82.7 Multiple fractures of lower leg	0.674	0.326
T14 Injury of unspecified body region	0.673	0.327
T93.0 Sequelae of open wound of lower limb	0.673	0.327
D84 Other immunodeficiencies	0.673	0.327
M25.55 Pain in joint (Pelvic region and thigh)	0.673	0.327
M30 Polyarteritis nodosa and related conditions	0.672	0.328
S82.9 Fracture of lower leg, part unspecified	0.671	0.328
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.671	0.329
Q35-Q37 Cleft lip and cleft palate	0.671	0.329
Q30-Q34 Congenital malformations of the respiratory system	0.671	0.329
T23 Burn and corrosion of wrist and hand	0.670	0.330
M25.9 Joint disorder, unspecified	0.670	0.330
M12 Other specific arthropathies	0.670	0.330
E11.7 With multiple complications	0.670	0.330
F53 Mental and behavioural disorders associated with the puerperium, not elsewhere classified	0.669	0.331
F51 Nonorganic sleep disorders	0.669	0.331
F59 Unspecified behavioural syndromes associated with physiological disturbances and physical factors	0.669	0.331
F55 Abuse of non-dependence-producing substances	0.669	0.331
F54 Psychological and behavioural factors associated with disorders or diseases classified elsewhere	0.669	0.331
G40 Epilepsy	0.669	0.331
M84.16 Nonunion of fracture [pseudarthrosis] (Lower leg)	0.669	0.331
S91.3 Open wound of other parts of foot	0.669	0.331
D86.8 Sarcoidosis of other and combined sites	0.668	0.332
S80.0 Contusion of knee	0.668	0.332
S99 Other and unspecified injuries of ankle and foot	0.667	0.333
E11.1 With ketoacidosis	0.667	0.333
W18 Other fall on same level	0.666	0.334
F99 Mental disorder, not otherwise specified	0.665	0.334
M85 Other disorders of bone density and structure	0.664	0.336
E21.5 Disorder of parathyroid gland, unspecified	0.664	0.336
E21.2 Other hyperparathyroidism	0.664	0.336
S37 Injury of urinary and pelvic organs	0.663	0.337
M84.0 Malunion of fracture	0.662	0.338
Y00-Y09 Assault	0.662	0.338
S81 Open wound of lower leg	0.661	0.339
Q63 Other congenital malformations of kidney	0.661	0.339
F48 Other neurotic disorders	0.661	0.339
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands	0.660	0.340
F32.8 Other depressive episodes	0.659	0.341
M90 Osteopathies in diseases classified elsewhere	0.659	0.341
C60-C63 Malignant neoplasms of male genital organs	0.659	0.341
C77.3 Axillary and upper limb lymph nodes	0.657	0.343
Y85.0 Sequelae of motor-vehicle accident	0.657	0.343
F64 Gender identity disorders	0.657	0.343
M87.9 Osteonecrosis, unspecified	0.657	0.343
D02.0 Larynx	0.656	0.343
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere	0.656	0.344
Y87 Sequelae of intentional self-harm, assault and events of undetermined intent	0.656	0.344
D55-D59 Haemolytic anaemias	0.656	0.344
E05 Thyrotoxicosis [hyperthyroidism]	0.656	0.344
E65-E68 Obesity and other hyperalimentation	0.655	0.345
M60-M63 Disorders of muscles	0.655	0.345
S32.0 Fracture of lumbar vertebra	0.655	0.345
F50.9 Eating disorder, unspecified	0.654	0.346
M83 Adult osteomalacia	0.654	0.346
E16 Other disorders of pancreatic internal secretion	0.653	0.347
C07 Malignant neoplasm of parotid gland	0.652	0.347
F33.8 Other recurrent depressive disorders	0.652	0.348
F33.4 Recurrent depressive disorder, currently in remission	0.652	0.348
E10.4 With neurological complications	0.652	0.348
Y84.1 Kidney dialysis	0.651	0.349
E14.7 With multiple complications	0.649	0.351
E14.6 With other specified complications	0.649	0.351
E14.5 With peripheral circulatory complications	0.649	0.351
E14.4 With neurological complications	0.649	0.351
E14.2 Withrenal complications	0.649	0.351
E14.1 With ketoacidosis	0.649	0.351
E14.0 With coma	0.649	0.351
Q87 Other specified congenital malformation syndromes affecting multiple systems	0.648	0.352
F00 Dementia in Alzheimer's disease	0.648	0.352
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.647	0.353
T15-T19 Effects of foreign body entering through natural orifice	0.647	0.353
C16 Malignant neoplasm of stomach	0.647	0.353
G70-G73 Diseases of myoneural junction and muscle	0.646	0.353
D46 Myelodysplastic syndromes	0.646	0.354
S82.86 Maisonneuve's fracture	0.646	0.354
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs	0.646	0.354
T88 Other complications of surgical and medical care, not elsewhere classified	0.646	0.354
D83 Common variable immunodeficiency	0.644	0.356
D82 Immunodeficiency associated with other major defects	0.644	0.356
D81 Combined immunodeficiencies	0.644	0.356
D60-D64 Aplastic and other anaemias	0.642	0.358
F50.0 Anorexia nervosa	0.642	0.358
S82.31 Fracture of lower end of tibia (open)	0.642	0.358
W13.9 Unspecified place	0.642	0.358
X60 Intentional self-poisoning by and exposure to nonopioid analgesics, antipyretics and antirheumatics	0.642	0.358
T63 Toxic effect of contact with venomous animals	0.642	0.358
D48.1 Connective and other soft tissue	0.641	0.359
T21 Burn and corrosion of trunk	0.641	0.359
Q38-Q45 Other congenital malformations of the digestive system	0.641	0.359
C18.2 Ascending colon	0.641	0.359
F50.2 Bulimia nervosa	0.640	0.360
Y84.8 Other medical procedures	0.640	0.360
W78 Inhalation of gastric contents	0.640	0.360
X49 Accidental poisoning by and exposure to other and unspecified chemicals and noxious substances	0.639	0.361
F80-F89 Disorders of psychological development	0.639	0.361
S10.9 Superficial injury of neck, part unspecified	0.639	0.361
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts	0.638	0.362
E24 Cushing's syndrome	0.638	0.362
F68 Other disorders of adult personality and behaviour	0.638	0.362
F66 Psychological and behavioural disorders associated with sexual development and orientation	0.638	0.362
F65 Disorders of sexual preference	0.638	0.362
F63 Habit and impulse disorders	0.638	0.362
F62 Enduring personality changes, not attributable to brain damage and disease	0.638	0.362
F69 Unspecified disorder of adult personality and behaviour	0.638	0.362
F61 Mixed and other personality disorders	0.638	0.362
L60-L75 Disorders of skin appendages	0.636	0.364
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes	0.636	0.364
T12.X1 Fracture of lower limb, level unspecified (open)	0.636	0.364
T12.X0 Fracture of lower limb, level unspecified (closed)	0.636	0.364
T12 Fracture of lower limb, level unspecified	0.636	0.364
T10.X1 Fracture of upper limb, level unspecified (open)	0.636	0.364
T10.X0 Fracture of upper limb, level unspecified (closed)	0.636	0.364
T10 Fracture of upper limb, level unspecified	0.636	0.364
T08.X1 Fracture of spine, level unspecified (open)	0.636	0.364
T08.X0 Fracture of spine, level unspecified (closed)	0.636	0.364
T08 Fracture of spine, level unspecified	0.636	0.364
T82.6 Infection and inflammatory reaction due to cardiac valve prosthesis	0.635	0.364
M81.8 Other osteoporosis	0.635	0.365
M81.6 Localised osteoporosis [Lequesne]	0.635	0.365
M81.5 Idiopathic osteoporosis	0.635	0.365
M81.3 Postsurgical malabsorption osteoporosis	0.635	0.365
M81.1 Postoophorectomy osteoporosis	0.635	0.365
M81.0 Postmenopausal osteoporosis	0.635	0.365
D45 Polycythaemia vera	0.635	0.365
M35 Other systemic involvement of connective tissue	0.634	0.365
M25.58 Pain in joint (Other)	0.634	0.366
S80.8 Other superficial injuries of lower leg	0.633	0.366
S32.00 Fracture of lumbar vertebra (closed)	0.632	0.368
E11.0 With coma	0.632	0.368
F41.0 Panic disorder [episodic paroxysmal anxiety]	0.632	0.368
X69 Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances	0.631	0.369
M14 Arthropathies in other diseases classified elsewhere	0.631	0.369
E27.5 Adrenomedullary hyperfunction	0.630	0.370
E27.3 Drug-induced adrenocortical insufficiency	0.630	0.370
E27.2 Addisonian crisis	0.630	0.370
E27.0 Other adrenocortical overactivity	0.630	0.370
G80 Infantile cerebral palsy	0.629	0.371
W02.9 Unspecified place	0.629	0.371
T25 Burn and corrosion of ankle and foot	0.628	0.372
T22 Burn and corrosion of shoulder and upper limb, except wrist and hand	0.628	0.372
T79 Certain early complications of trauma, not elsewhere classified	0.628	0.372
G00-G09 Inflammatory diseases of the central nervous system	0.627	0.372
M32 Systemic lupus erythematosus	0.627	0.372
M05 Seropositive rheumatoid arthritis	0.627	0.373
W03 Other fall on same level due to collision with, or pushing by, another person	0.627	0.373
T59 Toxic effect of other gases, fumes and vapours	0.626	0.374
S92.30 Fracture of metatarsal bone (closed)	0.626	0.374
Q27 Other congenital malformations of peripheral vascular system	0.625	0.374
C18.3 Hepatic flexure	0.625	0.375
D04.7 Skin of lower limb, including hip	0.625	0.375
T80.8 Other complications following infusion, transfusion and therapeutic injection	0.625	0.375
S13 Dislocation, sprain and strain of joints and ligaments at neck level	0.625	0.375
C00.0 External upper lip	0.625	0.375
S80.1 Contusion of other and unspecified parts of lower leg	0.624	0.375
X58 Exposure to other specified factors	0.624	0.376
E11.2 With renal complications	0.624	0.376
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.623	0.377
D80.1 Nonfamilial hypogammaglobulinaemia	0.622	0.378

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations