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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs8045590
log Bayes Factor = 6.79603
Chromosome 16   position 6,114,071  (GRCh37) Explore rs8045590 on Ensembl!
Variant rs8045590 is part of Cluster X0247

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.999 0.001 0.000
M20-M25 Other joint disorders
0.998 0.002 0.000
M24 Other specific joint derangements
0.993 0.007 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.993 0.007 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.991 0.009 0.000
Chapter XX External causes of morbidity and mortality
0.988 0.012 0.000
D69 Purpura and other haemorrhagic conditions
0.988 0.012 0.000
M15-M19 Arthrosis
0.979 0.021 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.979 0.021 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.975 0.025 0.000
Chapter I Certain infectious and parasitic diseases
0.974 0.026 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.972 0.028 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.972 0.028 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.969 0.031 0.000
M70-M79 Other soft tissue disorders
0.969 0.031 0.000
M17 Gonarthrosis [arthrosis of knee]
0.966 0.034 0.000
D60-D64 Aplastic and other anaemias
0.962 0.038 0.000
M17.9 Gonarthrosis, unspecified
0.960 0.040 0.000
D69.3 Idiopathic thrombocytopenic purpura
0.958 0.042 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.954 0.046 0.000
Chapter VI Diseases of the nervous system
0.953 0.047 0.000
D70 Agranulocytosis
0.947 0.053 0.000
E10-E14 Diabetes mellitus
0.947 0.053 0.000
M24.1 Other articular cartilage disorders
0.945 0.055 0.000
Chapter XXII Codes for special purposes
0.943 0.057 0.000
M80-M85 Disorders of bone density and structure
0.941 0.059 0.000
E11 Non-insulin-dependent diabetes mellitus
0.939 0.061 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.938 0.062 0.000
B35-B49 Mycoses
0.937 0.063 0.000
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts
0.936 0.064 0.000
M24.15 Other articular cartilage disorders (Pelvic region and thigh)
0.936 0.064 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.931 0.069 0.000
S50-S59 Injuries to the elbow and forearm
0.931 0.069 0.000
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts
0.931 0.069 0.000
M22 Disorders of patella
0.929 0.071 0.000
M17.3 Other posttraumatic gonarthrosis
0.929 0.071 0.000
G57 Mononeuropathies of lower limb
0.927 0.073 0.000
M34 Systemic sclerosis
0.926 0.074 0.000
E11.9 Without complications
0.924 0.076 0.000
D69.6 Thrombocytopenia, unspecified
0.923 0.077 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.922 0.078 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.922 0.078 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.920 0.080 0.000
M24.2 Disorder of ligament
0.920 0.080 0.000
G57.6 Lesion of plantar nerve
0.918 0.082 0.000
B37 Candidiasis
0.915 0.085 0.000
G20-G26 Extrapyramidal and movement disorders
0.915 0.085 0.000
T42.4 Benzodiazepines
0.912 0.088 0.000
M24.5 Contracture of joint
0.906 0.094 0.000
M84 Disorders of continuity of bone
0.905 0.095 0.000
T90 Sequelae of injuries of head
0.905 0.095 0.000
M05-M14 Inflammatory polyarthropathies
0.904 0.096 0.000
G20 Parkinson's disease
0.901 0.099 0.000
T84.0 Mechanical complication of internal joint prosthesis
0.896 0.104 0.000
M31 Other necrotising vasculopathies
0.892 0.108 0.000
D61 Other aplastic anaemias
0.892 0.108 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.892 0.108 0.000
S40-S49 Injuries to the shoulder and upper arm
0.889 0.111 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.888 0.112 0.000
T84.6 Infection and inflammatory reaction due to internal fixation device [any site]
0.886 0.114 0.000
T93 Sequelae of injuries of lower limb
0.882 0.118 0.000
E11.4 With neurological complications
0.881 0.119 0.000
T86 Failure and rejection of transplanted organs and tissues
0.877 0.123 0.000
D69.2 Other nonthrombocytopenic purpura
0.873 0.126 0.000
S51 Open wound of forearm
0.873 0.127 0.000
U80 Agent resistant to penicillin and related antibiotics
0.870 0.130 0.000
M84.0 Malunion of fracture
0.868 0.132 0.000
M31.6 Other giant cell arteritis
0.867 0.133 0.000
M60-M63 Disorders of muscles
0.864 0.136 0.000
E10 Insulin-dependent diabetes mellitus
0.862 0.138 0.000
M13 Other arthritis
0.857 0.143 0.000
M86-M90 Other osteopathies
0.857 0.143 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.857 0.143 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.857 0.143 0.000
W50-W64 Exposure to animate mechanical forces
0.854 0.145 0.000
M15 Polyarthrosis
0.854 0.146 0.000
M34.9 Systemic sclerosis, unspecified
0.854 0.146 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.854 0.146 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.847 0.153 0.000
G58 Other mononeuropathies
0.847 0.153 0.000
M22.2 Patellofemoral disorders
0.847 0.153 0.000
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts
0.844 0.156 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.841 0.159 0.000
M13.9 Arthritis, unspecified
0.837 0.163 0.000
M72 Fibroblastic disorders
0.836 0.164 0.000
D64 Other anaemias
0.836 0.164 0.000
U80.1 Methicillin resistant agent
0.835 0.165 0.000
M16 Coxarthrosis [arthrosis of hip]
0.835 0.165 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.833 0.167 0.000
S51.9 Open wound of forearm, part unspecified
0.832 0.168 0.000
T00-T07 Injuries involving multiple body regions
0.825 0.175 0.000
M76 Enthesopathies of lower limb, excluding foot
0.824 0.176 0.000
Y86 Sequelae of other accidents
0.822 0.178 0.000
T90.2 Sequelae of fracture of skull and facial bones
0.822 0.178 0.000
M24.24 Disorder of ligament (Hand)
0.821 0.179 0.000
M24.51 Contracture of joint (Shoulder region)
0.820 0.180 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.819 0.181 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.819 0.181 0.000
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts
0.818 0.182 0.000
D75 Other diseases of blood and blood-forming organs
0.818 0.182 0.000
D61.9 Aplastic anaemia, unspecified
0.817 0.183 0.000
T36 Poisoning by systemic antibiotics
0.815 0.184 0.000
D69.5 Secondary thrombocytopenia
0.811 0.189 0.000
T84.1 Mechanical complication of internal fixation device of bones of limb
0.810 0.190 0.000
X50-X57 Overexertion, travel and privation
0.810 0.190 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.810 0.190 0.000
U80.8 Agent resistant to other penicillin-related antibiotic
0.810 0.190 0.000
M24.85 Other specific joint derangements, not elsewhere classified (Pelvic region and thigh)
0.802 0.198 0.000
B49 Unspecified mycosis
0.802 0.198 0.000
E10.3 With ophthalmic complications
0.800 0.200 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.800 0.200 0.000
Y43 Primarily systemic agents
0.799 0.201 0.000
E20-E35 Disorders of other endocrine glands
0.799 0.201 0.000
T90.9 Sequelae of unspecified injury of head
0.792 0.208 0.000
M85 Other disorders of bone density and structure
0.791 0.209 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.791 0.209 0.000
B99-B99 Other infectious diseases
0.789 0.211 0.000
Y85 Sequelae of transport accidents
0.787 0.213 0.000
S20-S29 Injuries to the thorax
0.787 0.213 0.000
M25 Other joint disorders, not elsewhere classified
0.787 0.213 0.000
G57.8 Other mononeuropathies of lower limb
0.786 0.214 0.000
T87 Complications peculiar to reattachment and amputation
0.785 0.215 0.000
A00-A09 Intestinal infectious diseases
0.784 0.216 0.000
G58.8 Other specified mononeuropathies
0.783 0.217 0.000
T93.2 Sequelae of other fractures of lower limb
0.783 0.217 0.000
M24.27 Disorder of ligament (Ankle and foot)
0.782 0.218 0.000
B37.0 Candidal stomatitis
0.781 0.219 0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.780 0.220 0.000
B37.1 Pulmonary candidiasis
0.780 0.220 0.000
M84.4 Pathological fracture, not elsewhere classified
0.777 0.223 0.000
S70-S79 Injuries to the hip and thigh
0.776 0.224 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.776 0.224 0.000
M62 Other disorders of muscle
0.775 0.225 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.775 0.225 0.000
M22.8 Other disorders of patella
0.774 0.226 0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified
0.773 0.227 0.000
M16.3 Other dysplastic coxarthrosis
0.773 0.227 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.773 0.227 0.000
E11.6 With other specified complications
0.772 0.227 0.000
Q80-Q89 Other congenital malformations
0.772 0.228 0.000
T82.4 Mechanical complication of vascular dialysis catheter
0.772 0.228 0.000
S56 Injury of muscle and tendon at forearm level
0.772 0.228 0.000
D62 Acute posthaemorrhagic anaemia
0.770 0.230 0.000
M34.1 CR(E)ST syndrome
0.770 0.230 0.000
Y43.3 Other antineoplastic drugs
0.770 0.230 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.770 0.230 0.000
M77 Other enthesopathies
0.769 0.231 0.000
A15-A19 Tuberculosis
0.767 0.233 0.000
V10-V19 Pedal cyclist injured in transport accident
0.765 0.235 0.000
M13.95 Arthritis, unspecified (Pelvic region and thigh)
0.765 0.235 0.000
T95 Sequelae of burns, corrosions and frostbite
0.765 0.235 0.000
M79.0 Rheumatism, unspecified
0.762 0.238 0.000
M13.97 Arthritis, unspecified (Ankle and foot)
0.759 0.241 0.000
T86.1 Kidney transplant failure and rejection
0.757 0.243 0.000
W57 Bitten or stung by non-venomous insect and other non-venomous arthropods
0.757 0.243 0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis
0.757 0.243 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.753 0.247 0.000
B37.3 Candidiasis of vulva and vagina
0.750 0.250 0.000
T86.4 Liver transplant failure and rejection
0.750 0.250 0.000
B24 Unspecified human immunodeficiency virus [HIV] disease
0.749 0.251 0.000
V20-V29 Motorcycle rider injured in transport accident
0.748 0.252 0.000
Y85.9 Sequelae of other and unspecified transport accidents
0.747 0.253 0.000
X10-X19 Contact with heat and hot substances
0.746 0.254 0.000
S54 Injury of nerves at forearm level
0.745 0.255 0.000
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle
0.744 0.256 0.000
V40-V49 Car occupant injured in transport accident
0.744 0.256 0.000
M15.3 Secondary multiple arthrosis
0.743 0.257 0.000
A30-A49 Other bacterial diseases
0.743 0.257 0.000
M84.06 Malunion of fracture (Lower leg)
0.743 0.257 0.000
T98 Sequelae of other and unspecified effects of external causes
0.743 0.257 0.000
E23 Hypofunction and other disorders of pituitary gland
0.741 0.259 0.000
B15-B19 Viral hepatitis
0.739 0.261 0.000
M32 Systemic lupus erythematosus
0.739 0.261 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.739 0.261 0.000
T82.0 Mechanical complication of heart valve prosthesis
0.738 0.262 0.000
M21 Other acquired deformities of limbs
0.737 0.263 0.000
B37.8 Candidiasis of other sites
0.736 0.264 0.000
V01-V09 Pedestrian injured in transport accident
0.736 0.264 0.000
M24.57 Contracture of joint (Ankle and foot)
0.736 0.264 0.000
D55-D59 Haemolytic anaemias
0.735 0.265 0.000
M72.0 Palmar fascial fibromatosis [Dupuytren]
0.734 0.266 0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs
0.733 0.267 0.000
D64.9 Anaemia, unspecified
0.733 0.267 0.000
D66 Hereditary factor VIII deficiency
0.732 0.267 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.732 0.268 0.000
D69.4 Other primary thrombocytopenia
0.732 0.268 0.000
M87 Osteonecrosis
0.732 0.268 0.000
M22.0 Recurrent dislocation of patella
0.732 0.268 0.000
B37.9 Candidiasis, unspecified
0.731 0.269 0.000
M13.99 Arthritis, unspecified (Site unspecified)
0.730 0.270 0.000
E11.8 With unspecified complications
0.729 0.271 0.000
M79.2 Neuralgia and neuritis, unspecified
0.729 0.271 0.000
B50-B64 Protozoal diseases
0.729 0.271 0.000
M95 Other acquired deformities of musculoskeletal system and connective tissue
0.727 0.272 0.000
M16.5 Other posttraumatic coxarthrosis
0.727 0.273 0.000
M25.4 Effusion of joint
0.727 0.273 0.000
B37.7 Candidal septicaemia
0.727 0.273 0.000
T43.3 Phenothiazine antipsychotics and neuroleptics
0.727 0.273 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.725 0.275 0.000
D61.1 Drug-induced aplastic anaemia
0.724 0.275 0.000
E10.0 With coma
0.724 0.276 0.000
M24.7 Protrusio acetabuli
0.724 0.276 0.000
T90.8 Sequelae of other specified injuries of head
0.722 0.278 0.000
T43.0 Tricyclic and tetracyclic antidepressants
0.721 0.279 0.000
V80-V89 Other land transport accidents
0.721 0.279 0.000
G57.1 Meralgia paraesthetica
0.721 0.279 0.000
M84.01 Malunion of fracture (Shoulder region)
0.719 0.281 0.000
G70-G73 Diseases of myoneural junction and muscle
0.719 0.281 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.718 0.282 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.718 0.282 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
M24.81 Other specific joint derangements, not elsewhere classified (Shoulder region)
0.717 0.283 0.000
Q50-Q56 Congenital malformations of genital organs
0.717 0.283 0.000
D73 Diseases of spleen
0.716 0.284 0.000
T14 Injury of unspecified body region
0.716 0.284 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.715 0.285 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.715 0.285 0.000
M13.98 Arthritis, unspecified (Other)
0.715 0.285 0.000
M76.6 Achilles tendinitis
0.715 0.285 0.000
M00-M03 Infectious arthropathies
0.714 0.286 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.714 0.286 0.000
M85.6 Other cyst of bone
0.713 0.287 0.000
M13.92 Arthritis, unspecified (Upper arm)
0.712 0.287 0.000
T66-T78 Other and unspecified effects of external causes
0.712 0.288 0.000
M24.9 Joint derangement, unspecified
0.712 0.288 0.000
M24.6 Ankylosis of joint
0.712 0.288 0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified
0.712 0.288 0.000
M62.8 Other specified disorders of muscle
0.712 0.288 0.000
M84.02 Malunion of fracture (Upper arm)
0.711 0.289 0.000
D67 Hereditary factor IX deficiency
0.710 0.289 0.000
M82 Osteoporosis in diseases classified elsewhere
0.710 0.290 0.000
M65-M68 Disorders of synovium and tendon
0.710 0.290 0.000
Y35-Y36 Legal intervention and operations of war
0.708 0.292 0.000
Y10-Y34 Event of undetermined intent
0.708 0.292 0.000
X85-X99 Assault
0.708 0.292 0.000
X30-X39 Exposure to forces of nature
0.708 0.292 0.000
X00-X09 Exposure to smoke, fire and flames
0.708 0.292 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.708 0.292 0.000
W75-W84 Other accidental threats to breathing
0.708 0.292 0.000
W65-W74 Accidental drowning and submersion
0.708 0.292 0.000
V98-V99 Other and unspecified transport accidents
0.708 0.292 0.000
V95-V97 Air and space transport accidents
0.708 0.292 0.000
V90-V94 Water transport accidents
0.708 0.292 0.000
V70-V79 Bus occupant injured in transport accident
0.708 0.292 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.708 0.292 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.708 0.292 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.708 0.292 0.000
D69.8 Other specified haemorrhagic conditions
0.708 0.292 0.000
D69.1 Qualitative platelet defects
0.708 0.292 0.000
T43.6 Psychostimulants with abuse potential
0.706 0.294 0.000
M84.04 Malunion of fracture (Hand)
0.706 0.294 0.000
S51.0 Open wound of elbow
0.706 0.294 0.000
M75 Shoulder lesions
0.705 0.295 0.000
S42 Fracture of shoulder and upper arm
0.705 0.295 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.702 0.298 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.702 0.298 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.702 0.298 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.702 0.298 0.000
T91 Sequelae of injuries of neck and trunk
0.701 0.299 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.700 0.300 0.000
T00 Superficial injuries involving multiple body regions
0.699 0.301 0.000
S49 Other and unspecified injuries of shoulder and upper arm
0.699 0.301 0.000
T25 Burn and corrosion of ankle and foot
0.698 0.302 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.698 0.302 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.698 0.302 0.000
A75-A79 Rickettsioses
0.698 0.302 0.000
A70-A74 Other diseases caused by chlamydiae
0.698 0.302 0.000
A20-A28 Certain zoonotic bacterial diseases
0.698 0.302 0.000
T93.9 Sequelae of unspecified injury of lower limb
0.698 0.302 0.000
T36.0 Penicillins
0.698 0.302 0.000
D75.2 Essential thrombocytosis
0.698 0.302 0.000
X60-X84 Intentional self-harm
0.698 0.302 0.000
T82.6 Infection and inflammatory reaction due to cardiac valve prosthesis
0.697 0.303 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.697 0.303 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.697 0.303 0.000
M24.21 Disorder of ligament (Shoulder region)
0.695 0.304 0.000
D74 Methaemoglobinaemia
0.695 0.305 0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.695 0.305 0.000
D71 Functional disorders of polymorphonuclear neutrophils
0.695 0.305 0.000
S73 Dislocation, sprain and strain of joint and ligaments of hip
0.695 0.305 0.000
M11 Other crystal arthropathies
0.694 0.305 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.694 0.306 0.000
M10 Gout
0.694 0.306 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.693 0.307 0.000
M17.4 Other secondary gonarthrosis, bilateral
0.693 0.307 0.000
M17.2 Posttraumatic gonarthrosis, bilateral
0.693 0.307 0.000
M16.2 Coxarthrosis resulting from dysplasia, bilateral
0.692 0.308 0.000
B36 Other superficial mycoses
0.691 0.309 0.000
S40 Superficial injury of shoulder and upper arm
0.691 0.309 0.000
B25-B34 Other viral diseases
0.690 0.310 0.000
E10.8 With unspecified complications
0.690 0.310 0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.689 0.310 0.000
Y88 Sequelae of surgical and medical care as external cause
0.688 0.312 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.687 0.313 0.000
T93.3 Sequelae of dislocation, sprain and strain of lower limb
0.683 0.317 0.000
A65-A69 Other spirochaetal diseases
0.683 0.317 0.000
M16.6 Other secondary coxarthrosis, bilateral
0.683 0.317 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.681 0.319 0.000
E11.1 With ketoacidosis
0.681 0.319 0.000
G57.5 Tarsal tunnel syndrome
0.681 0.319 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.681 0.319 0.000
E23.7 Disorder of pituitary gland, unspecified
0.681 0.319 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.681 0.319 0.000
M79.4 Hypertrophy of (infrapatellar) fat pad
0.680 0.320 0.000
G50 Disorders of trigeminal nerve
0.680 0.320 0.000
E12 Malnutrition-related diabetes mellitus
0.679 0.321 0.000
E11.5 With peripheral circulatory complications
0.678 0.322 0.000
M24.19 Other articular cartilage disorders (Site unspecified)
0.677 0.323 0.000
M24.18 Other articular cartilage disorders (Other)
0.677 0.323 0.000
M24.14 Other articular cartilage disorders (Hand)
0.677 0.323 0.000
M24.12 Other articular cartilage disorders (Upper arm)
0.677 0.323 0.000
M24.10 Other articular cartilage disorders (Multiple sites)
0.677 0.323 0.000
W57.0 Home
0.676 0.324 0.000
M83 Adult osteomalacia
0.675 0.325 0.000
E11.7 With multiple complications
0.673 0.327 0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants
0.672 0.328 0.000
T42.5 Mixed antiepileptics, not elsewhere classified
0.672 0.328 0.000
T42.3 Barbiturates
0.672 0.328 0.000
T42.2 Succinimides and oxazolidinediones
0.672 0.328 0.000
T42.0 Hydantoin derivatives
0.672 0.328 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.672 0.328 0.000
B48 Other mycoses, not elsewhere classified
0.672 0.328 0.000
B47 Mycetoma
0.672 0.328 0.000
B46 Zygomycosis
0.672 0.328 0.000
B45 Cryptococcosis
0.672 0.328 0.000
B43 Chromomycosis and phaeomycotic abscess
0.672 0.328 0.000
B42 Sporotrichosis
0.672 0.328 0.000
B41 Paracoccidioidomycosis
0.672 0.328 0.000
B40 Blastomycosis
0.672 0.328 0.000
B39 Histoplasmosis
0.672 0.328 0.000
B38 Coccidioidomycosis
0.672 0.328 0.000
T11 Other injuries of upper limb, level unspecified
0.672 0.328 0.000
G59 Mononeuropathy in diseases classified elsewhere
0.671 0.329 0.000
B23 Human immunodeficiency virus [HIV] disease resulting in other conditions
0.669 0.331 0.000
M79.6 Pain in limb
0.668 0.332 0.000
G52 Disorders of other cranial nerves
0.668 0.332 0.000
M15.1 Heberden's nodes (with arthropathy)
0.668 0.332 0.000
S58 Traumatic amputation of forearm
0.667 0.333 0.000
S57 Crushing injury of forearm
0.667 0.333 0.000
S55 Injury of blood vessels at forearm level
0.667 0.333 0.000
S53 Dislocation, sprain and strain of joints and ligaments of elbow
0.667 0.333 0.000
M79.9 Soft tissue disorder, unspecified
0.667 0.333 0.000
G53 Cranial nerve disorders in diseases classified elsewhere
0.667 0.333 0.000
E65-E68 Obesity and other hyperalimentation
0.667 0.333 0.000
M22.1 Recurrent subluxation of patella
0.666 0.334 0.000
M22.9 Disorder of patella, unspecified
0.666 0.334 0.000
M72.1 Knuckle pads
0.666 0.334 0.000
Y79 Orthopaedic devices associated with adverse incidents
0.666 0.334 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.665 0.335 0.000
M24.83 Other specific joint derangements, not elsewhere classified (Forearm)
0.665 0.335 0.000
T82.9 Unspecified complication of cardiac and vascular prosthetic device, implant and graft
0.664 0.336 0.000
G57.9 Mononeuropathy of lower limb, unspecified
0.664 0.336 0.000
G57.4 Lesion of medial popliteal nerve
0.664 0.336 0.000
G57.3 Lesion of lateral popliteal nerve
0.664 0.336 0.000
G57.2 Lesion of femoral nerve
0.664 0.336 0.000
M34.2 Systemic sclerosis induced by drugs and chemicals
0.664 0.336 0.000
M34.0 Progressive systemic sclerosis
0.664 0.336 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.664 0.336 0.000
M30 Polyarteritis nodosa and related conditions
0.663 0.337 0.000
A08 Viral and other specified intestinal infections
0.663 0.337 0.000
G54 Nerve root and plexus disorders
0.663 0.337 0.000
W20-W49 Exposure to inanimate mechanical forces
0.662 0.337 0.000
G24 Dystonia
0.662 0.338 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.662 0.338 0.000
A63 Other predominantly sexually transmitted diseases, not elsewhere classified
0.661 0.339 0.000
Y89 Sequelae of other external causes
0.661 0.339 0.000
G57.0 Lesion of sciatic nerve
0.661 0.339 0.000
T43.9 Psychotropic drug, unspecified
0.661 0.339 0.000
T43.8 Other psychotropic drugs, not elsewhere classified
0.661 0.339 0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.661 0.339 0.000
Y43.0 Antiallergic and antiemetic drugs
0.661 0.339 0.000
B37.4 Candidiasis of other urogenital sites
0.660 0.339 0.000
M72.04 Palmar fascial fibromatosis [Dupuytren]-Hand
0.661 0.339 0.000
S20 Superficial injury of thorax
0.660 0.339 0.000
Q35-Q37 Cleft lip and cleft palate
0.660 0.340 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.660 0.340 0.000
M24.29 Disorder of ligament (Site unspecified)
0.660 0.340 0.000
M24.28 Disorder of ligament (Other)
0.660 0.340 0.000
M24.25 Disorder of ligament (Pelvic region and thigh)
0.660 0.340 0.000
M24.22 Disorder of ligament (Upper arm)
0.660 0.340 0.000
M24.20 Disorder of ligament (Multiple sites)
0.660 0.340 0.000
E70-E90 Metabolic disorders
0.659 0.341 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.659 0.341 0.000
D75.9 Disease of blood and blood-forming organs, unspecified
0.659 0.341 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.659 0.341 0.000
Y87 Sequelae of intentional self-harm, assault and events of undetermined intent
0.658 0.341 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.658 0.342 0.000
M14 Arthropathies in other diseases classified elsewhere
0.658 0.342 0.000
T93.1 Sequelae of fracture of femur
0.658 0.342 0.000
X50 Overexertion and strenuous or repetitive movements
0.658 0.342 0.000
Y43.4 Immunosuppressive agents
0.657 0.343 0.000
T43.2 Other and unspecified antidepressants
0.657 0.343 0.000
B99 Other and unspecified infectious diseases
0.656 0.344 0.000
B37.6 Candidal endocarditis
0.656 0.344 0.000
B37.5 Candidal meningitis
0.656 0.344 0.000
B37.2 Candidiasis of skin and nail
0.656 0.344 0.000
G23 Other degenerative diseases of basal ganglia
0.656 0.344 0.000
G21 Secondary Parkinsonism
0.656 0.344 0.000
G26 Extrapyramidal and movement disorders in diseases classified elsewhere
0.656 0.344 0.000
G22 Parkinsonism in diseases classified elsewhere
0.656 0.344 0.000
T82.2 Mechanical complication of coronary artery bypass and valve grafts
0.656 0.344 0.000
Q00-Q07 Congenital malformations of the nervous system
0.655 0.345 0.000
E29 Testicular dysfunction
0.654 0.346 0.000
M06 Other rheumatoid arthritis
0.654 0.346 0.000
E78.5 Hyperlipidaemia, unspecified
0.653 0.347 0.000
M24.26 Disorder of ligament (Lower leg)
0.651 0.349 0.000
M24.11 Other articular cartilage disorders (Shoulder region)
0.650 0.349 0.000
M77.0 Medial epicondylitis
0.650 0.350 0.000
Q74 Other congenital malformations of limb(s)
0.650 0.350 0.000
W55 Bitten or struck by other mammals
0.650 0.350 0.000
M24.59 Contracture of joint (Site unspecified)
0.650 0.350 0.000
M24.58 Contracture of joint (Other)
0.650 0.350 0.000
M24.55 Contracture of joint (Pelvic region and thigh)
0.650 0.350 0.000
M24.53 Contracture of joint (Forearm)
0.650 0.350 0.000
M24.52 Contracture of joint (Upper arm)
0.650 0.350 0.000
M24.50 Contracture of joint (Multiple sites)
0.650 0.350 0.000
Q43 Other congenital malformations of intestine
0.649 0.351 0.000
S46 Injury of muscle and tendon at shoulder and upper arm level
0.649 0.351 0.000
E10.2 With renal complications
0.649 0.351 0.000
S10-S19 Injuries to the neck
0.649 0.351 0.000
M99 Biomechanical lesions, not elsewhere classified
0.649 0.351 0.000
M84.9 Disorder of continuity of bone, unspecified
0.649 0.351 0.000
M84.8 Other disorders of continuity of bone
0.649 0.351 0.000
M84.3 Stress fracture, not elsewhere classified
0.649 0.351 0.000
M84.2 Delayed union of fracture
0.649 0.351 0.000
T90.3 Sequelae of injury of cranial nerves
0.649 0.351 0.000
T90.1 Sequelae of open wound of head
0.649 0.351 0.000
T90.0 Sequelae of superficial injury of head
0.649 0.351 0.000
M12 Other specific arthropathies
0.648 0.352 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.648 0.352 0.000
M08 Juvenile arthritis
0.648 0.352 0.000
S50 Superficial injury of forearm
0.647 0.352 0.000
M24.87 Other specific joint derangements, not elsewhere classified (Ankle and foot)
0.647 0.353 0.000
X20-X29 Contact with venomous animals and plants
0.647 0.353 0.000
D69.0 Allergic purpura
0.646 0.354 0.000
Y76 Obstetric and gynaecological devices associated with adverse incidents
0.646 0.354 0.000
M84.03 Malunion of fracture (Forearm)
0.646 0.354 0.000
T51 Toxic effect of alcohol
0.645 0.355 0.000
R47-R49 Symptoms and signs involving speech and voice
0.645 0.355 0.000
M33 Dermatopolymyositis
0.644 0.356 0.000
M24.56 Contracture of joint (Lower leg)
0.644 0.356 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.644 0.356 0.000
M86 Osteomyelitis
0.643 0.356 0.000
M89 Other disorders of bone
0.643 0.357 0.000
M84.07 Malunion of fracture (Ankle and foot)
0.643 0.357 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.642 0.358 0.000
M87.9 Osteonecrosis, unspecified
0.641 0.359 0.000
M79.00 Rheumatism, unspecified (Multiple sites)
0.641 0.359 0.000
S56.1 Injury of flexor muscle and tendon of other finger(s) at forearm level
0.641 0.359 0.000
T82.1 Mechanical complication of cardiac electronic device
0.640 0.360 0.000
M75.2 Bicipital tendinitis
0.640 0.360 0.000
M84.45 Pathological fracture, not elsewhere classified (Pelvic region and thigh)
0.640 0.360 0.000
Y71 Cardiovascular devices associated with adverse incidents
0.640 0.360 0.000
M31.9 Necrotising vasculopathy, unspecified
0.640 0.360 0.000
M31.8 Other specified necrotising vasculopathies
0.640 0.360 0.000
M31.7 Microscopic polyangiitis
0.640 0.360 0.000
M31.4 Aortic arch syndrome [Takayasu]
0.640 0.360 0.000
M31.2 Lethal midline granuloma
0.640 0.360 0.000
M31.1 Thrombotic microangiopathy
0.640 0.360 0.000
M31.0 Hypersensitivity angiitis
0.640 0.360 0.000
D61.8 Other specified aplastic anaemias
0.640 0.360 0.000
D61.3 Idiopathic aplastic anaemia
0.640 0.360 0.000
D61.2 Aplastic anaemia due to other external agents
0.640 0.360 0.000
D61.0 Constitutional aplastic anaemia
0.640 0.360 0.000
T79-T79 Certain early complications of trauma
0.640 0.360 0.000
U50 Level of care administered to neonates
0.639 0.361 0.000
U07 Emergency use of U07
0.639 0.361 0.000
U06 Emergency use of U06
0.639 0.361 0.000
U04 Severe acute respiratory syndrome [SARS]
0.639 0.361 0.000
U52 First in a series of a regular day/night admissions
0.639 0.361 0.000
T24 Burn and corrosion of hip and lower limb, except ankle and foot
0.638 0.362 0.000
S48 Traumatic amputation of shoulder and upper arm
0.637 0.363 0.000
S45 Injury of blood vessels at shoulder and upper arm level
0.637 0.363 0.000
S44 Injury of nerves at shoulder and upper arm level
0.637 0.363 0.000
S47 Crushing injury of shoulder and upper arm
0.637 0.363 0.000
S73.0 Dislocation of hip
0.637 0.363 0.000
X41 Accidental poisoning by and exposure to antiepileptic, sedative-hypnotic, anti-Parkinsonism and psychotropic drugs, not elsewhere classified
0.637 0.363 0.000
M24.89 Other specific joint derangements, not elsewhere classified (Site unspecified)
0.636 0.363 0.000
M24.88 Other specific joint derangements, not elsewhere classified (Other)
0.636 0.363 0.000
M24.84 Other specific joint derangements, not elsewhere classified (Hand)
0.636 0.363 0.000
M24.82 Other specific joint derangements, not elsewhere classified (Upper arm)
0.636 0.363 0.000
M24.80 Other specific joint derangements, not elsewhere classified (Multiple sites)
0.636 0.363 0.000
M17.5 Other secondary gonarthrosis
0.635 0.364 0.000
Y77 Ophthalmic devices associated with adverse incidents
0.635 0.365 0.000
M71 Other bursopathies
0.635 0.365 0.000
G30-G32 Other degenerative diseases of the nervous system
0.635 0.365 0.000
V18 Pedal cyclist injured in noncollision transport accident
0.635 0.365 0.000
G61 Inflammatory polyneuropathy
0.635 0.365 0.000
Y57 Other and unspecified drugs and medicaments
0.634 0.366 0.000
M24.54 Contracture of joint (Hand)
0.634 0.366 0.000
D63 Anaemia in chronic diseases classified elsewhere
0.634 0.366 0.000
Q38 Other congenital malformations of tongue, mouth and pharynx
0.633 0.367 0.000
M90 Osteopathies in diseases classified elsewhere
0.633 0.367 0.000
Q78 Other osteochondrodysplasias
0.633 0.367 0.000
W60 Contact with plant thorns and spines and sharp leaves
0.633 0.367 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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