TreeWAS – Variant ID: rs9268541

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
N17-N19 Renal failure	1.000	0.000	0.000
Chapter XIV Diseases of the genitourinary system	1.000	0.000	0.000
# Top node	1.000	0.000	0.000
N18 Chronic renal failure	1.000	0.000	0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.000	0.000	1.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.999	0.001	0.000
M06.9 Rheumatoid arthritis, unspecified	0.000	0.002	0.998
Chapter IX Diseases of the circulatory system	0.998	0.002	0.000
N18.9 Chronic renal failure, unspecified	0.998	0.002	0.000
E03.9 Hypothyroidism, unspecified	0.996	0.004	0.000
I10-I15 Hypertensive diseases	0.996	0.004	0.000
I12.0 Hypertensive renal disease with renal failure	0.995	0.005	0.000
I12 Hypertensive renal disease	0.995	0.005	0.000
E03 Other hypothyroidism	0.995	0.005	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.994	0.006	0.000
E00-E07 Disorders of thyroid gland	0.993	0.007	0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.000	0.007	0.993
D80-D89 Certain disorders involving the immune mechanism	0.991	0.009	0.000
N00-N08 Glomerular diseases	0.987	0.013	0.000
D86 Sarcoidosis	0.985	0.015	0.000
N17 Acute renal failure	0.981	0.019	0.000
N10-N16 Renal tubulo-interstitial diseases	0.980	0.020	0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.978	0.022	0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.977	0.023	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.977	0.023	0.000
D86.0 Sarcoidosis of lung	0.969	0.031	0.000
N13 Obstructive and reflux uropathy	0.968	0.032	0.000
N17.9 Acute renal failure, unspecified	0.965	0.035	0.000
N20-N23 Urolithiasis	0.960	0.040	0.000
N13.3 Other and unspecified hydronephrosis	0.956	0.044	0.000
N25-N29 Other disorders of kidney and ureter	0.955	0.045	0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified	0.944	0.056	0.000
D68 Other coagulation defects	0.943	0.057	0.000
N18.4 Chronic kidney disease, stage 4	0.942	0.058	0.000
Chapter V Mental and behavioural disorders	0.938	0.062	0.000
N03 Chronic nephritic syndrome	0.930	0.070	0.000
N20 Calculus of kidney and ureter	0.926	0.074	0.000
F30-F39 Mood [affective] disorders	0.925	0.075	0.000
N05 Unspecified nephritic syndrome	0.921	0.079	0.000
N28 Other disorders of kidney and ureter, not elsewhere classified	0.919	0.081	0.000
E10-E14 Diabetes mellitus	0.914	0.086	0.000
N18.3 Chronic kidney disease, stage 3	0.914	0.086	0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.000	0.093	0.907
I89 Other non-infective disorders of lymphatic vessels and lymph nodes	0.899	0.101	0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified	0.897	0.103	0.000
N20.0 Calculus of kidney	0.897	0.103	0.000
F31 Bipolar affective disorder	0.896	0.104	0.000
S90-S99 Injuries to the ankle and foot	0.890	0.110	0.000
N03.9 Unspecified	0.889	0.111	0.000
N28.1 Cyst of kidney, acquired	0.885	0.115	0.000
I80 Phlebitis and thrombophlebitis	0.879	0.121	0.000
I89.0 Lymphoedema, not elsewhere classified	0.874	0.126	0.000
E10 Insulin-dependent diabetes mellitus	0.873	0.127	0.000
S40-S49 Injuries to the shoulder and upper arm	0.872	0.128	0.000
N19 Unspecified renal failure	0.872	0.128	0.000
D86.9 Sarcoidosis, unspecified	0.872	0.128	0.000
I05-I09 Chronic rheumatic heart diseases	0.869	0.131	0.000
N13.2 Hydronephrosis with renal and ureteral calculous obstruction	0.867	0.133	0.000
I80.2 Phlebitis and thrombophlebitis of other deep vessels of lower extremities	0.858	0.142	0.000
Q60-Q64 Congenital malformations of the urinary system	0.853	0.147	0.000
Chapter XXII Codes for special purposes	0.851	0.149	0.000
D68.5 Primary Thrombophilia	0.850	0.150	0.000
N18.5 Chronic kidney disease, stage 5	0.849	0.151	0.000
T85 Complications of other internal prosthetic devices, implants and grafts	0.847	0.153	0.000
D69 Purpura and other haemorrhagic conditions	0.846	0.154	0.000
D50-D53 Nutritional anaemias	0.845	0.155	0.000
N18.8 Other chronic renal failure	0.841	0.159	0.000
N21 Calculus of lower urinary tract	0.840	0.160	0.000
N18.0 End-stage renal disease	0.839	0.161	0.000
N13.4 Hydroureter	0.837	0.163	0.000
Q80-Q89 Other congenital malformations	0.834	0.166	0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts	0.827	0.173	0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.826	0.174	0.000
F30 Manic episode	0.825	0.175	0.000
N04 Nephrotic syndrome	0.820	0.180	0.000
N05.9 Unspecified	0.820	0.180	0.000
D68.8 Other specified coagulation defects	0.810	0.190	0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.809	0.191	0.000
T20-T25 Burns and corrosions of external body surface, specified by site	0.805	0.195	0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)	0.000	0.196	0.804
N05.2 Diffuse membranous glomerulonephritis	0.799	0.201	0.000
T36-T50 Poisoning by drugs, medicaments and biological substances	0.798	0.202	0.000
I15 Secondary hypertension	0.798	0.202	0.000
Chapter VI Diseases of the nervous system	0.788	0.212	0.000
T85.5 Mechanical complication of gastro-intestinal prosthetic devices, implants and grafts	0.788	0.212	0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.787	0.213	0.000
D68.2 Hereditary deficiency of other clotting factors	0.786	0.214	0.000
F34 Persistent mood [affective] disorders	0.785	0.215	0.000
T79-T79 Certain early complications of trauma	0.785	0.215	0.000
I85 Oesophageal varices	0.784	0.216	0.000
S20-S29 Injuries to the thorax	0.784	0.216	0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)	0.000	0.217	0.783
I60-I69 Cerebrovascular diseases	0.782	0.218	0.000
S46 Injury of muscle and tendon at shoulder and upper arm level	0.782	0.218	0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.000	0.222	0.778
Q20-Q28 Congenital malformations of the circulatory system	0.777	0.223	0.000
E10.4 With neurological complications	0.775	0.225	0.000
N20.2 Calculus of kidney with calculus of ureter	0.774	0.226	0.000
I11 Hypertensive heart disease	0.773	0.227	0.000
F39 Unspecified mood [affective] disorder	0.772	0.228	0.000
N28.0 Ischaemia and infarction of kidney	0.771	0.229	0.000
D80 Immunodeficiency with predominantly antibody defects	0.771	0.229	0.000
Q38-Q45 Other congenital malformations of the digestive system	0.771	0.229	0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use	0.771	0.229	0.000
N28.9 Disorder of kidney and ureter, unspecified	0.770	0.230	0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.770	0.230	0.000
F70-F79 Mental retardation	0.769	0.231	0.000
G50-G59 Nerve, nerve root and plexus disorders	0.767	0.233	0.000
F31.9 Bipolar affective disorder, unspecified	0.763	0.237	0.000
I81 Portal vein thrombosis	0.762	0.237	0.000
T66-T78 Other and unspecified effects of external causes	0.759	0.240	0.000
D86.1 Sarcoidosis of lymph nodes	0.759	0.241	0.000
D60-D64 Aplastic and other anaemias	0.758	0.242	0.000
E13 Other specified diabetes mellitus	0.757	0.243	0.000
F31.0 Bipolar affective disorder, current episode hypomanic	0.756	0.244	0.000
Chapter I Certain infectious and parasitic diseases	0.752	0.248	0.000
N13.7 Vesicoureteral-reflux-associated uropathy	0.751	0.249	0.000
N99-N99 Other disorders of the genitourinary system	0.750	0.249	0.000
E10.3 With ophthalmic complications	0.749	0.251	0.000
N02 Recurrent and persistent haematuria	0.748	0.252	0.000
Chapter II Neoplasms	0.747	0.253	0.000
I05 Rheumatic mitral valve diseases	0.746	0.254	0.000
S90 Superficial injury of ankle and foot	0.746	0.254	0.000
F30.0 Hypomania	0.745	0.254	0.000
D51 Vitamin B12 deficiency anaemia	0.745	0.255	0.000
E03.8 Other specified hypothyroidism	0.745	0.255	0.000
Q61 Cystic kidney disease	0.744	0.256	0.000
N17.0 Acute renal failure with tubular necrosis	0.741	0.259	0.000
E06 Thyroiditis	0.739	0.261	0.000
S92 Fracture of foot, except ankle	0.738	0.262	0.000
Q00-Q07 Congenital malformations of the nervous system	0.737	0.263	0.000
C64-C68 Malignant neoplasms of urinary tract	0.737	0.263	0.000
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level	0.736	0.264	0.000
T15-T19 Effects of foreign body entering through natural orifice	0.730	0.269	0.000
E10.9 Without complications	0.730	0.270	0.000
G56 Mononeuropathies of upper limb	0.729	0.271	0.000
D86.8 Sarcoidosis of other and combined sites	0.728	0.272	0.000
T63 Toxic effect of contact with venomous animals	0.726	0.274	0.000
N12 Tubulo-interstitial nephritis, not specified as acute or chronic	0.720	0.280	0.000
N21.0 Calculus in bladder	0.719	0.281	0.000
C67 Malignant neoplasm of bladder	0.719	0.281	0.000
T83.4 Mechanical complication of other prosthetic devices, implants and grafts in genital tract	0.718	0.281	0.000
F31.3 Bipolar affective disorder, current episode mild or moderate depression	0.717	0.283	0.000
Chapter XVI Certain conditions originating in the perinatal period	0.717	0.283	0.000
N18.1 Chronic kidney disease, stage 1	0.717	0.283	0.000
I00-I02 Acute rheumatic fever	0.716	0.284	0.000
M06.98 Rheumatoid arthritis, unspecified (Other)	0.000	0.284	0.716
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.000	0.284	0.716
M06.93 Rheumatoid arthritis, unspecified (Forearm)	0.000	0.284	0.716
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.000	0.284	0.716
A00-A09 Intestinal infectious diseases	0.715	0.285	0.000
N20.9 Urinary calculus, unspecified	0.715	0.285	0.000
I13 Hypertensive heart and renal disease	0.714	0.286	0.000
I61 Intracerebral haemorrhage	0.714	0.286	0.000
I08 Multiple valve diseases	0.714	0.286	0.000
S50-S59 Injuries to the elbow and forearm	0.713	0.287	0.000
E03.5 Myxoedema coma	0.713	0.287	0.000
E03.4 Atrophy of thyroid (acquired)	0.713	0.287	0.000
E03.3 Postinfectious hypothyroidism	0.713	0.287	0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.713	0.287	0.000
E03.1 Congenital hypothyroidism without goitre	0.713	0.287	0.000
E03.0 Congenital hypothyroidism with diffuse goitre	0.713	0.287	0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.712	0.288	0.000
E00 Congenital iodine-deficiency syndrome	0.712	0.288	0.000
E02 Subclinical iodine-deficiency hypothyroidism	0.712	0.288	0.000
U80 Agent resistant to penicillin and related antibiotics	0.712	0.288	0.000
D84 Other immunodeficiencies	0.710	0.289	0.000
D83 Common variable immunodeficiency	0.710	0.289	0.000
D82 Immunodeficiency associated with other major defects	0.710	0.289	0.000
D81 Combined immunodeficiencies	0.710	0.289	0.000
C15-C26 Malignant neoplasms of digestive organs	0.710	0.290	0.000
I95-I99 Other and unspecified disorders of the circulatory system	0.709	0.291	0.000
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts	0.709	0.291	0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.708	0.292	0.000
A08 Viral and other specified intestinal infections	0.708	0.292	0.000
N07 Hereditary nephropathy, not elsewhere classified	0.708	0.292	0.000
N06 Isolated proteinuria with specified morphological lesion	0.708	0.292	0.000
N01 Rapidly progressive nephritic syndrome	0.708	0.292	0.000
N00 Acute nephritic syndrome	0.708	0.292	0.000
D86.3 Sarcoidosis of skin	0.706	0.294	0.000
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes	0.706	0.294	0.000
D68.6 Other Thrombophilia	0.706	0.294	0.000
I86 Varicose veins of other sites	0.705	0.295	0.000
T87 Complications peculiar to reattachment and amputation	0.704	0.295	0.000
N26 Unspecified contracted kidney	0.704	0.296	0.000
E07 Other disorders of thyroid	0.704	0.296	0.000
F00-F09 Organic, including symptomatic, mental disorders	0.704	0.296	0.000
N17.8 Other acute renal failure	0.703	0.297	0.000
N17.2 Acute renal failure with medullary necrosis	0.703	0.297	0.000
N17.1 Acute renal failure with acute cortical necrosis	0.703	0.297	0.000
F31.4 Bipolar affective disorder, current episode severe depression without psychotic symptoms	0.703	0.297	0.000
N18.2 Chronic kidney disease, stage 2	0.703	0.297	0.000
N16 Renal tubulo-interstitial disorders in diseases classified elsewhere	0.703	0.297	0.000
N15 Other renal tubulo-interstitial diseases	0.703	0.297	0.000
N14 Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions	0.703	0.297	0.000
S42 Fracture of shoulder and upper arm	0.703	0.297	0.000
Q85 Phakomatoses, not elsewhere classified	0.703	0.297	0.000
A08.4 Viral intestinal infection, unspecified	0.702	0.298	0.000
T33-T35 Frostbite	0.701	0.299	0.000
T26-T28 Burns and corrosions confined to eye and internal organs	0.701	0.299	0.000
T00-T07 Injuries involving multiple body regions	0.701	0.299	0.000
N04.9 Unspecified	0.701	0.299	0.000
D67 Hereditary factor IX deficiency	0.700	0.300	0.000
D66 Hereditary factor VIII deficiency	0.700	0.300	0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.700	0.300	0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.700	0.300	0.000
Q35-Q37 Cleft lip and cleft palate	0.700	0.300	0.000
Q30-Q34 Congenital malformations of the respiratory system	0.700	0.300	0.000
D68.3 Haemorrhagic disorder due to circulating anticoagulants	0.700	0.300	0.000
S46.0 Injury of tendon of the rotator cuff of shoulder	0.700	0.300	0.000
D55-D59 Haemolytic anaemias	0.699	0.300	0.000
G70-G73 Diseases of myoneural junction and muscle	0.699	0.301	0.000
F31.1 Bipolar affective disorder, current episode manic without psychotic symptoms	0.695	0.304	0.000
T83.8 Other complications of genito-urinary prosthetic devices, implants and grafts	0.690	0.310	0.000
E40-E46 Malnutrition	0.689	0.310	0.000
T83.0 Mechanical complication of urinary (indwelling) catheter	0.689	0.311	0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.689	0.311	0.000
D69.3 Idiopathic thrombocytopenic purpura	0.689	0.311	0.000
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency	0.689	0.311	0.000
D52 Folate deficiency anaemia	0.689	0.311	0.000
F31.2 Bipolar affective disorder, current episode manic with psychotic symptoms	0.688	0.311	0.000
N22 Calculus of urinary tract in diseases classified elsewhere	0.688	0.312	0.000
D69.9 Haemorrhagic condition, unspecified	0.688	0.312	0.000
G59 Mononeuropathy in diseases classified elsewhere	0.686	0.314	0.000
F34.1 Dysthymia	0.685	0.315	0.000
N29 Other disorders of kidney and ureter in diseases classified elsewhere	0.684	0.316	0.000
N27 Small kidney of unknown cause	0.684	0.316	0.000
N25 Disorders resulting from impaired renal tubular function	0.684	0.316	0.000
F31.6 Bipolar affective disorder, current episode mixed	0.683	0.317	0.000
I87 Other disorders of veins	0.683	0.317	0.000
I85.9 Oesophageal varices without bleeding	0.682	0.318	0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified	0.681	0.319	0.000
S10-S19 Injuries to the neck	0.680	0.320	0.000
N11 Chronic tubulo-interstitial nephritis	0.678	0.322	0.000
I88 Nonspecific lymphadenitis	0.677	0.323	0.000
D68.4 Acquired coagulation factor deficiency	0.676	0.324	0.000
D68.1 Hereditary factor XI deficiency	0.676	0.324	0.000
G54 Nerve root and plexus disorders	0.676	0.324	0.000
C67.9 Bladder, unspecified	0.674	0.326	0.000
Q50-Q56 Congenital malformations of genital organs	0.673	0.327	0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence	0.672	0.327	0.000
I89.8 Other specified non-infective disorders of lymphatic vessels and lymph nodes	0.672	0.328	0.000
T83.1 Mechanical complication of other urinary devices and implants	0.672	0.328	0.000
N21.1 Calculus in urethra	0.669	0.331	0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors	0.669	0.331	0.000
N03.8 Other	0.667	0.333	0.000
N03.7 Diffuse crescentic glomerulonephritis	0.667	0.333	0.000
N03.6 Dense deposit disease	0.667	0.333	0.000
N03.5 Diffuse mesangiocapillary glomerulonephritis	0.667	0.333	0.000
N03.4 Diffuse endocapillary proliferative glomerulonephritis	0.667	0.333	0.000
N03.3 Diffuse mesangial proliferative glomerulonephritis	0.667	0.333	0.000
N03.2 Diffuse membranous glomerulonephritis	0.667	0.333	0.000
N03.1 Focal and segmental glomerular lesions	0.667	0.333	0.000
N03.0 Minor glomerular abnormality	0.667	0.333	0.000
T85.0 Mechanical complication of ventricular intracranial (communicating) shunt	0.666	0.334	0.000
D68.9 Coagulation defect, unspecified	0.665	0.335	0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.665	0.335	0.000
N10 Acute tubulo-interstitial nephritis	0.664	0.336	0.000
T85.8 Other complications of internal prosthetic devices, implants and grafts, not elsewhere classified	0.663	0.337	0.000
F38 Other mood [affective] disorders	0.663	0.337	0.000
G56.2 Lesion of ulnar nerve	0.663	0.337	0.000
D68.0 Von Willebrand's disease	0.662	0.338	0.000
I70-I79 Diseases of arteries, arterioles and capillaries	0.662	0.338	0.000
N13.8 Other obstructive and reflux uropathy	0.662	0.338	0.000
D69.0 Allergic purpura	0.661	0.339	0.000
Q61.2 Polycystic kidney, adult type	0.661	0.339	0.000
F60-F69 Disorders of adult personality and behaviour	0.661	0.339	0.000
N05.8 Other	0.660	0.339	0.000
N05.7 Diffuse crescentic glomerulonephritis	0.660	0.339	0.000
N05.6 Dense deposit disease	0.660	0.339	0.000
N05.5 Diffuse mesangiocapillary glomerulonephritis	0.660	0.339	0.000
N05.4 Diffuse endocapillary proliferative glomerulonephritis	0.660	0.339	0.000
N05.3 Diffuse mesangial proliferative glomerulonephritis	0.660	0.339	0.000
N05.1 Focal and segmental glomerular lesions	0.660	0.339	0.000
N05.0 Minor glomerular abnormality	0.660	0.339	0.000
E10.5 With peripheral circulatory complications	0.660	0.339	0.000
I12.9 Hypertensive renal disease without renal failure	0.660	0.340	0.000
Q87 Other specified congenital malformation syndromes affecting multiple systems	0.659	0.341	0.000
I08.1 Disorders of both mitral and tricuspid valves	0.658	0.342	0.000
E12 Malnutrition-related diabetes mellitus	0.655	0.345	0.000
T63.4 Venom of other arthropods	0.655	0.345	0.000
I69 Sequelae of cerebrovascular disease	0.651	0.349	0.000
T11 Other injuries of upper limb, level unspecified	0.651	0.349	0.000
T85.2 Mechanical complication of intraocular lens	0.651	0.349	0.000
F79 Unspecified mental retardation	0.648	0.352	0.000
G58 Other mononeuropathies	0.648	0.352	0.000
E10.1 With ketoacidosis	0.647	0.353	0.000
I80.9 Phlebitis and thrombophlebitis of unspecified site	0.646	0.354	0.000
T79 Certain early complications of trauma, not elsewhere classified	0.646	0.354	0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.646	0.354	0.000
I89.9 Non-infective disorder of lymphatic vessels and lymph nodes, unspecified	0.644	0.356	0.000
N13.6 Pyonephrosis	0.644	0.356	0.000
E13.9 Without complications	0.644	0.356	0.000
T09 Other injuries of spine and trunk, level unspecified	0.644	0.356	0.000
G90-G99 Other disorders of the nervous system	0.642	0.358	0.000
F31.8 Other bipolar affective disorders	0.642	0.358	0.000
F31.7 Bipolar affective disorder, currently in remission	0.642	0.358	0.000
F31.5 Bipolar affective disorder, current episode severe depression with psychotic symptoms	0.642	0.358	0.000
N13.9 Obstructive and reflux uropathy, unspecified	0.642	0.358	0.000
F99-F99 Unspecified mental disorder	0.641	0.359	0.000
I82 Other venous embolism and thrombosis	0.641	0.359	0.000
T80 Complications following infusion, transfusion and therapeutic injection	0.641	0.359	0.000
T81 Complications of procedures, not elsewhere classified	0.641	0.359	0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.641	0.359	0.000
D53 Other nutritional anaemias	0.640	0.359	0.000
Q17 Other congenital malformations of ear	0.640	0.360	0.000
Q63 Other congenital malformations of kidney	0.640	0.360	0.000
S40 Superficial injury of shoulder and upper arm	0.640	0.360	0.000
Q28 Other congenital malformations of circulatory system	0.639	0.361	0.000
T88 Other complications of surgical and medical care, not elsewhere classified	0.638	0.362	0.000
S98 Traumatic amputation of ankle and foot	0.638	0.362	0.000
S97 Crushing injury of ankle and foot	0.638	0.362	0.000
S96 Injury of muscle and tendon at ankle and foot level	0.638	0.362	0.000
S95 Injury of blood vessels at ankle and foot level	0.638	0.362	0.000
S94 Injury of nerves at ankle and foot level	0.638	0.362	0.000
T21 Burn and corrosion of trunk	0.638	0.362	0.000
F80-F89 Disorders of psychological development	0.637	0.362	0.000
S00-S09 Injuries to the head	0.637	0.363	0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.637	0.363	0.000
T22 Burn and corrosion of shoulder and upper limb, except wrist and hand	0.635	0.365	0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs	0.635	0.365	0.000
I05.1 Rheumatic mitral insufficiency	0.634	0.366	0.000
S20 Superficial injury of thorax	0.634	0.366	0.000
Q82 Other congenital malformations of skin	0.631	0.368	0.000
C19 Malignant neoplasm of rectosigmoid junction	0.631	0.369	0.000
G56.0 Carpal tunnel syndrome	0.631	0.369	0.000
S29 Other and unspecified injuries of thorax	0.631	0.369	0.000
Q60 Renal agenesis and other reduction defects of kidney	0.630	0.370	0.000
E65-E68 Obesity and other hyperalimentation	0.630	0.370	0.000
U80.8 Agent resistant to other penicillin-related antibiotic	0.630	0.370	0.000
C25 Malignant neoplasm of pancreas	0.629	0.371	0.000
G59.0 Diabetic mononeuropathy	0.628	0.371	0.000
E10.8 With unspecified complications	0.626	0.374	0.000
E10.7 With multiple complications	0.626	0.374	0.000
E10.6 With other specified complications	0.626	0.374	0.000
E10.0 With coma	0.626	0.374	0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.626	0.374	0.000
S48 Traumatic amputation of shoulder and upper arm	0.625	0.374	0.000
S45 Injury of blood vessels at shoulder and upper arm level	0.625	0.374	0.000
S44 Injury of nerves at shoulder and upper arm level	0.625	0.374	0.000
S41 Open wound of shoulder and upper arm	0.625	0.374	0.000
S47 Crushing injury of shoulder and upper arm	0.625	0.374	0.000
S93.1 Dislocation of toe(s)	0.625	0.375	0.000
T86 Failure and rejection of transplanted organs and tissues	0.624	0.375	0.000
I15.9 Seconday hypertension, unspecified	0.624	0.376	0.000
G80-G83 Cerebral palsy and other paralytic syndromes	0.623	0.376	0.000
I09 Other rheumatic heart diseases	0.623	0.377	0.000
I06 Rheumatic aortic valve diseases	0.623	0.377	0.000
C24 Malignant neoplasm of other and unspecified parts of biliary tract	0.621	0.379	0.000
S99 Other and unspecified injuries of ankle and foot	0.619	0.380	0.000
N13.0 Hydronephrosis with ureteropelvic junction obstruction	0.619	0.381	0.000
S42.3 Fracture of shaft of humerus	0.617	0.383	0.000
F30.9 Manic episode, unspecified	0.617	0.383	0.000
Q38 Other congenital malformations of tongue, mouth and pharynx	0.616	0.384	0.000
I80.1 Phlebitis and thrombophlebitis of femoral vein	0.616	0.384	0.000
N08 Glomerular disorders in diseases classified elsewhere	0.616	0.384	0.000
I60 Subarachnoid haemorrhage	0.614	0.386	0.000
F05 Delirium, not induced by alcohol and other psychoactive substances	0.614	0.386	0.000
D80.1 Nonfamilial hypogammaglobulinaemia	0.614	0.386	0.000
I05.9 Mitral valve disease, unspecified	0.613	0.386	0.000
I15.1 Hypertension secondary to other renal disorders	0.613	0.387	0.000
I11.9 Hypertensive heart disease without (congestive) heart failure	0.613	0.387	0.000
Q64 Other congenital malformations of urinary system	0.612	0.388	0.000
Q62 Congenital obstructive defects of renal pelvis and congenital malformations of ureter	0.612	0.388	0.000
I80.3 Phlebitis and thrombophlebitis of lower extremities, unspecified	0.612	0.388	0.000
S91 Open wound of ankle and foot	0.611	0.389	0.000
Chapter XX External causes of morbidity and mortality	0.609	0.391	0.000
T85.9 Unspecified complication of internal prosthetic device, implant and graft	0.607	0.393	0.000
T85.1 Mechanical complication of implanted electronic stimulator of nervous system	0.607	0.393	0.000
S46.2 Injury of muscle and tendon of other parts of biceps	0.606	0.394	0.000
D69.8 Other specified haemorrhagic conditions	0.606	0.394	0.000
D69.5 Secondary thrombocytopenia	0.606	0.394	0.000
D69.4 Other primary thrombocytopenia	0.606	0.394	0.000
D69.2 Other nonthrombocytopenic purpura	0.606	0.394	0.000
D69.1 Qualitative platelet defects	0.606	0.394	0.000
E05 Thyrotoxicosis [hyperthyroidism]	0.606	0.394	0.000
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle	0.604	0.396	0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders	0.604	0.396	0.000
C66 Malignant neoplasm of ureter	0.603	0.397	0.000
I69.0 Sequelae of subarachnoid haemorrhage	0.603	0.397	0.000
N21.9 Calculus of lower urinary tract, unspecified	0.602	0.398	0.000
N21.8 Other lower urinary tract calculus	0.602	0.398	0.000
I61.5 Intracerebral haemorrhage, intraventricular	0.601	0.399	0.000
M06 Other rheumatoid arthritis	0.007	0.399	0.594
I86.8 Varicose veins of other specified sites	0.601	0.399	0.000
I30-I52 Other forms of heart disease	0.600	0.400	0.000
I67 Other cerebrovascular diseases	0.599	0.401	0.000
Q86 Congenital malformation syndromes due to known exogenous causes, not elsewhere classified	0.598	0.402	0.000
Q84 Other congenital malformations of integument	0.598	0.402	0.000
Q83 Congenital malformations of breast	0.598	0.402	0.000
Q81 Epidermolysis bullosa	0.598	0.402	0.000
Q80 Congenital ichthyosis	0.598	0.402	0.000
C67.4 Posterior wall of bladder	0.598	0.402	0.000
T85.4 Mechanical complication of breast prosthesis and implant	0.598	0.402	0.000
Q27 Other congenital malformations of peripheral vascular system	0.597	0.403	0.000
T81.2 Accidental puncture and laceration during a procedure, not elsewhere classified	0.597	0.403	0.000
C23 Malignant neoplasm of gallbladder	0.597	0.403	0.000
U80.1 Methicillin resistant agent	0.597	0.403	0.000
D62 Acute posthaemorrhagic anaemia	0.597	0.403	0.000
Q07 Other congenital malformations of nervous system	0.596	0.404	0.000
S90.3 Contusion of other and unspecified parts of foot	0.594	0.406	0.000
S50 Superficial injury of forearm	0.594	0.406	0.000
T59 Toxic effect of other gases, fumes and vapours	0.593	0.406	0.000
T83.9 Unspecified complication of genito-urinary prosthetic device, implant and graft	0.593	0.407	0.000
T83.6 Infection and inflammatory reaction due to prosthetic device, implant and graft in genital tract	0.593	0.407	0.000
T83.2 Mechanical complication of graft of urinary organ	0.593	0.407	0.000
T65 Toxic effect of other and unspecified substances	0.592	0.407	0.000
T62 Toxic effect of other noxious substances eaten as food	0.592	0.407	0.000
T61 Toxic effect of noxious substances eaten as seafood	0.592	0.407	0.000
T60 Toxic effect of pesticides	0.592	0.407	0.000
T57 Toxic effect of other inorganic substances	0.592	0.407	0.000
T56 Toxic effect of metals	0.592	0.407	0.000
T54 Toxic effect of corrosive substances	0.592	0.407	0.000
T53 Toxic effect of halogen derivatives of aliphatic and aromatic hydrocarbone	0.592	0.407	0.000
T52 Toxic effect of organic solvents	0.592	0.407	0.000
T64 Toxic effect of aflatoxin and other mycotoxin food contaminants	0.592	0.407	0.000
T58 Toxic effect of carbon monoxide	0.592	0.407	0.000
T55 Toxic effect of soaps and detergents	0.592	0.407	0.000
F30.8 Other manic episodes	0.592	0.408	0.000
F30.2 Mania with psychotic symptoms	0.592	0.408	0.000
F30.1 Mania without psychotic symptoms	0.592	0.408	0.000
T13 Other injuries of lower limb, level unspecified	0.591	0.409	0.000
Q65 Congenital deformities of hip	0.590	0.409	0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.590	0.410	0.000
Q85.0 Neurofibromatosis (nonmalignant)	0.589	0.411	0.000
N04.8 Other	0.588	0.412	0.000
N04.7 Diffuse crescentic glomerulonephritis	0.588	0.412	0.000
N04.6 Dense deposit disease	0.588	0.412	0.000
N04.5 Diffuse mesangiocapillary glomerulonephritis	0.588	0.412	0.000
N04.4 Diffuse endocapillary proliferative glomerulonephritis	0.588	0.412	0.000
N04.3 Diffuse mesangial proliferative glomerulonephritis	0.588	0.412	0.000
N04.2 Diffuse membranous glomerulonephritis	0.588	0.412	0.000
N04.1 Focal and segmental glomerular lesions	0.588	0.412	0.000
N04.0 Minor glomerular abnormality	0.588	0.412	0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.588	0.412	0.000
T68 Hypothermia	0.587	0.413	0.000
N13.1 Hydronephrosis with ureteral stricture, not elsewhere classified	0.586	0.414	0.000
E50-E64 Other nutritional deficiencies	0.585	0.415	0.000
G72 Other myopathies	0.585	0.415	0.000
G57 Mononeuropathies of lower limb	0.583	0.417	0.000
C64 Malignant neoplasm of kidney, except renal pelvis	0.583	0.417	0.000
S92.0 Fracture of calcaneus	0.582	0.417	0.000
C67.0 Trigone of bladder	0.582	0.418	0.000
G91 Hydrocephalus	0.582	0.418	0.000
D64 Other anaemias	0.581	0.419	0.000
Q18 Other congenital malformations of face and neck	0.581	0.419	0.000
D37-D48 Neoplasms of uncertain or unknown behaviour	0.581	0.419	0.000
T12.X1 Fracture of lower limb, level unspecified (open)	0.580	0.420	0.000
T12.X0 Fracture of lower limb, level unspecified (closed)	0.580	0.420	0.000
T12 Fracture of lower limb, level unspecified	0.580	0.420	0.000
T10.X1 Fracture of upper limb, level unspecified (open)	0.580	0.420	0.000
T10.X0 Fracture of upper limb, level unspecified (closed)	0.580	0.420	0.000
T10 Fracture of upper limb, level unspecified	0.580	0.420	0.000
T08.X1 Fracture of spine, level unspecified (open)	0.580	0.420	0.000
T08.X0 Fracture of spine, level unspecified (closed)	0.580	0.420	0.000
T08 Fracture of spine, level unspecified	0.580	0.420	0.000
B50-B64 Protozoal diseases	0.580	0.420	0.000
C20 Malignant neoplasm of rectum	0.579	0.421	0.000
S49 Other and unspecified injuries of shoulder and upper arm	0.578	0.422	0.000
I51 Complications and ill-defined descriptions of heart disease	0.577	0.423	0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs	0.577	0.423	0.000
S90.9 Superficial injury of ankle and foot, unspecified	0.577	0.423	0.000
T25 Burn and corrosion of ankle and foot	0.577	0.423	0.000
T24 Burn and corrosion of hip and lower limb, except ankle and foot	0.577	0.423	0.000
T23 Burn and corrosion of wrist and hand	0.577	0.423	0.000
T20 Burn and corrosion of head and neck	0.577	0.423	0.000
C26 Malignant neoplasm of other and ill-defined digestive organs	0.576	0.424	0.000
Q66 Congenital deformities of feet	0.576	0.424	0.000
D52.9 Folate deficiency anaemia, unspecified	0.576	0.424	0.000
I07 Rheumatic tricuspid valve diseases	0.576	0.424	0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue	0.576	0.424	0.000
S92.4 Fracture of great toe	0.575	0.425	0.000
N02.9 Unspecified	0.575	0.425	0.000
Q44 Congenital malformations of gallbladder, bile ducts and liver	0.575	0.425	0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.575	0.425	0.000
S70-S79 Injuries to the hip and thigh	0.574	0.426	0.000
Q61.3 Polycystic kidney, unspecified	0.573	0.427	0.000
G71 Primary disorders of muscles	0.573	0.427	0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.572	0.428	0.000
T41 Poisoning by anaesthetics and therapeutic gases	0.572	0.428	0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.572	0.428	0.000
T36 Poisoning by systemic antibiotics	0.572	0.428	0.000
I15.8 Other secondary hypertension	0.572	0.428	0.000
I15.2 Hypertension secondary to endocrine disorders	0.572	0.428	0.000
I15.0 Renovascular hypertension	0.572	0.428	0.000
N99 Postprocedural disorders of genito-urinary system, not elsewhere classified	0.572	0.428	0.000
C67.5 Bladder neck	0.571	0.429	0.000
T51 Toxic effect of alcohol	0.571	0.429	0.000
T46 Poisoning by agents primarily affecting the cardiovascular system	0.569	0.431	0.000
T48.6 Antiasthmatics, not elsewhere classified	0.569	0.431	0.000
I78 Diseases of capillaries	0.569	0.431	0.000
C50-C50 Malignant neoplasm of breast	0.568	0.432	0.000
S05 Injury of eye and orbit	0.567	0.433	0.000
T88.7 Unspecified adverse effect of drug or medicament	0.567	0.433	0.000
T16 Foreign body in ear	0.567	0.433	0.000
Q76 Congenital malformations of spine and bony thorax	0.566	0.434	0.000
F01 Vascular dementia	0.566	0.434	0.000
S90.8 Other superficial injuries of ankle and foot	0.566	0.434	0.000
B25-B34 Other viral diseases	0.565	0.435	0.000
G58.9 Mononeuropathy, unspecified	0.565	0.435	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations