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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs1109771
log Bayes Factor = 113.955
Chromosome 6   position 32,187,605  (GRCh37) Explore rs1109771 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
I10 Essential (primary) hypertension
0.000 0.001 0.999
E05.9 Thyrotoxicosis, unspecified
0.000 0.001 0.999
E10.3 With ophthalmic complications
0.000 0.002 0.998
E10.1 With ketoacidosis
0.000 0.003 0.997
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.005 0.995
E14 Unspecified diabetes mellitus
0.000 0.006 0.994
G35-G37 Demyelinating diseases of the central nervous system
0.990 0.010 0.000
G37 Other demyelinating diseases of central nervous system
0.987 0.013 0.000
G37.9 Demyelinating disease of central nervous system, unspecified
0.982 0.018 0.000
E11.3 With ophthalmic complications
0.000 0.023 0.977
E14.3 With ophthalmic complications
0.000 0.036 0.964
E11.1 With ketoacidosis
0.000 0.046 0.954
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.050 0.950
E11.5 With peripheral circulatory complications
0.000 0.055 0.945
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.000 0.063 0.937
I74 Arterial embolism and thrombosis
0.000 0.066 0.934
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.076 0.924
E10.8 With unspecified complications
0.000 0.083 0.917
E16 Other disorders of pancreatic internal secretion
0.000 0.086 0.914
E14.9 Without complications
0.000 0.103 0.897
I10-I15 Hypertensive diseases
0.000 0.104 0.896
E11.2 With renal complications
0.000 0.106 0.894
E10.4 With neurological complications
0.000 0.117 0.883
E20-E35 Disorders of other endocrine glands
0.000 0.121 0.879
E16.2 Hypoglycaemia, unspecified
0.000 0.129 0.871
Chapter IX Diseases of the circulatory system
0.000 0.131 0.869
I71 Aortic aneurysm and dissection
0.000 0.155 0.845
G37.8 Other specified demyelinating diseases of central nervous system
0.844 0.155 0.000
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.000 0.160 0.840
E14.1 With ketoacidosis
0.000 0.160 0.840
I73 Other peripheral vascular diseases
0.000 0.174 0.826
E10.5 With peripheral circulatory complications
0.000 0.178 0.822
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.184 0.816
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.190 0.810
I20-I25 Ischaemic heart diseases
0.000 0.195 0.805
I22 Subsequent myocardial infarction
0.000 0.197 0.803
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.795 0.205 0.000
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.206 0.794
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.000 0.206 0.794
E10.0 With coma
0.000 0.207 0.793
I74.8 Embolism and thrombosis of other arteries
0.000 0.207 0.793
E07 Other disorders of thyroid
0.000 0.209 0.791
E14.8 With unspecified complications
0.000 0.210 0.790
I73.9 Peripheral vascular disease, unspecified
0.000 0.213 0.787
I72 Other aneurysm
0.000 0.226 0.774
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.000 0.229 0.771
G36 Other acute disseminated demyelination
0.769 0.231 0.000
E21.3 Hyperparathyroidism, unspecified
0.000 0.237 0.763
E14.2 Withrenal complications
0.000 0.237 0.763
I71.0 Dissection of aorta [any part]
0.000 0.237 0.763
E10.7 With multiple complications
0.000 0.241 0.759
E10.2 With renal complications
0.000 0.245 0.755
E14.4 With neurological complications
0.000 0.251 0.749
E23 Hypofunction and other disorders of pituitary gland
0.000 0.272 0.728
E14.5 With peripheral circulatory complications
0.000 0.275 0.725
I72.4 Aneurysm of artery of lower extremity
0.000 0.277 0.723
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.278 0.722
I74.5 Embolism and thrombosis of iliac artery
0.000 0.278 0.722
E03.1 Congenital hypothyroidism without goitre
0.000 0.279 0.721
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.287 0.713
E14.7 With multiple complications
0.000 0.287 0.712
E16.1 Other hypoglycaemia
0.000 0.289 0.711
G37.5 Concentric sclerosis [Balo]
0.708 0.292 0.000
G37.4 Subacute necrotising myelitis
0.708 0.292 0.000
G37.2 Central pontine myelinolysis
0.708 0.292 0.000
G37.1 Central demyelination of corpus callosum
0.708 0.292 0.000
G37.0 Diffuse sclerosis
0.708 0.292 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.298 0.701
E10.6 With other specified complications
0.000 0.304 0.696
E65-E68 Obesity and other hyperalimentation
0.000 0.310 0.690
E29 Testicular dysfunction
0.000 0.310 0.689
E11.7 With multiple complications
0.000 0.312 0.688
E14.0 With coma
0.000 0.315 0.685
E28 Ovarian dysfunction
0.000 0.315 0.685
E15 Nondiabetic hypoglycaemic coma
0.000 0.319 0.681
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.322 0.678
I77 Other disorders of arteries and arterioles
0.000 0.330 0.670
E25 Adrenogenital disorders
0.000 0.337 0.663
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.000 0.337 0.663
I13 Hypertensive heart and renal disease
0.000 0.342 0.658
E21.2 Other hyperparathyroidism
0.000 0.342 0.658
E40-E46 Malnutrition
0.000 0.342 0.657
E23.2 Diabetes insipidus
0.000 0.343 0.657
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.345 0.655
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.345 0.655
E16.4 Abnormal secretion of gastrin
0.000 0.345 0.655
E16.3 Increased secretion of glucagon
0.000 0.345 0.655
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.346 0.654
I05-I09 Chronic rheumatic heart diseases
0.000 0.349 0.651
E03.8 Other specified hypothyroidism
0.000 0.352 0.648
E31 Polyglandular dysfunction
0.000 0.357 0.642
E11.8 With unspecified complications
0.000 0.363 0.636
E34 Other endocrine disorders
0.000 0.364 0.636
E07.9 Disorder of thyroid, unspecified
0.000 0.364 0.636
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.000 0.364 0.636
E11.0 With coma
0.000 0.367 0.633
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.369 0.630
E32 Diseases of thymus
0.000 0.369 0.630
E30 Disorders of puberty, not elsewhere classified
0.000 0.369 0.630
E20 Hypoparathyroidism
0.000 0.370 0.630
I72.9 Aneurysm of unspecified site
0.000 0.373 0.627
I77.9 Disorder of arteries and arterioles, unspecified
0.000 0.374 0.626
I70 Atherosclerosis
0.000 0.374 0.626
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.377 0.623
I00-I02 Acute rheumatic fever
0.000 0.381 0.619
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.383 0.617
I08 Multiple valve diseases
0.000 0.385 0.615
I71.1 Thoracic aortic aneurysm, ruptured
0.000 0.386 0.614
G36.0 Neuromyelitis optica [Devic]
0.610 0.390 0.000
I71.8 Aortic aneurysm of unspecified site, ruptured
0.000 0.394 0.606
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.000 0.394 0.606
I11 Hypertensive heart disease
0.000 0.397 0.603
I72.3 Aneurysm of iliac artery
0.000 0.399 0.600
I73.1 Thromboangiitis obliterans [Buerger]
0.000 0.402 0.598
I08.0 Disorders of both mitral and aortic valves
0.000 0.404 0.596
E23.6 Other disorders of pituitary gland
0.000 0.413 0.587
E21.4 Other specified disorders of parathyroid gland
0.000 0.415 0.585
I72.1 Aneurysm of artery of upper extremity
0.000 0.418 0.582
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.000 0.418 0.582
I77.1 Stricture of artery
0.000 0.420 0.580
I08.1 Disorders of both mitral and tricuspid valves
0.000 0.421 0.579
E07.8 Other specified disorders of thyroid
0.000 0.424 0.576
E14.6 With other specified complications
0.000 0.425 0.575
E13 Other specified diabetes mellitus
0.000 0.428 0.572
E22 Hyperfunction of pituitary gland
0.000 0.429 0.571
E07.1 Dyshormogenetic goitre
0.000 0.432 0.567
E07.0 Hypersecretion of calcitonin
0.000 0.432 0.567
I74.0 Embolism and thrombosis of abdominal aorta
0.000 0.433 0.567
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.433 0.567
I22.8 Subsequent myocardial infarction of other sites
0.000 0.437 0.563
E28.2 Polycystic ovarian syndrome
0.000 0.438 0.562
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.440 0.560
I23 Certain current complications following acute myocardial infarction
0.000 0.441 0.559
I77.0 Arteriovenous fistula, acquired
0.000 0.442 0.558
I72.2 Aneurysm of renal artery
0.000 0.442 0.558
I72.6 Aneurysm and dissection of vertebral artery
0.000 0.445 0.555
I72.5 Aneurysm and dissection of other precerebral arteries
0.000 0.445 0.555
E29.1 Testicular hypofunction
0.000 0.446 0.553
E23.7 Disorder of pituitary gland, unspecified
0.000 0.447 0.553
G36.9 Acute disseminated demyelination, unspecified
0.551 0.449 0.000
G36.8 Other specified acute disseminated demyelination
0.551 0.449 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.551 0.449 0.000
I73.0 Raynaud's syndrome
0.000 0.456 0.544
I24 Other acute ischaemic heart diseases
0.000 0.456 0.544
E26 Hyperaldosteronism
0.000 0.458 0.542
I74.9 Embolism and thrombosis of unspecified artery
0.000 0.463 0.537
E05.8 Other thyrotoxicosis
0.000 0.465 0.534
E24 Cushing's syndrome
0.000 0.467 0.533
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.000 0.473 0.527
I15 Secondary hypertension
0.000 0.474 0.525
E65 Localised adiposity
0.000 0.475 0.525
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.478 0.522
E23.1 Drug-induced hypopituitarism
0.000 0.478 0.522
I70.0 Atherosclerosis of aorta
0.000 0.479 0.521
E06 Thyroiditis
0.000 0.479 0.520
I79.1 Aortitis in diseases classified elsewhere
0.000 0.486 0.514
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
I20 Angina pectoris
0.000 0.490 0.510
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.491 0.509
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.496 0.504
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.498 0.502
K90 Intestinal malabsorption
0.000 0.498 0.501
E34.8 Other specified endocrine disorders
0.000 0.505 0.495
E67 Other hyperalimentation
0.000 0.505 0.495
E68 Sequelae of hyperalimentation
0.000 0.505 0.495
E29.9 Testicular dysfunction, unspecified
0.000 0.505 0.494
E29.8 Other testicular dysfunction
0.000 0.505 0.494
E29.0 Testicular hyperfunction
0.000 0.505 0.494
E28.9 Ovarian dysfunction, unspecified
0.000 0.509 0.491
E28.8 Other ovarian dysfunction
0.000 0.509 0.491
E28.1 Androgen excess
0.000 0.509 0.491
E28.0 Oestrogen excess
0.000 0.509 0.491
I70.8 Atherosclerosis of other arteries
0.000 0.513 0.486
I77.5 Necrosis of artery
0.000 0.520 0.480
I77.4 Coeliac artery compression syndrome
0.000 0.520 0.480
E22.1 Hyperprolactinaemia
0.000 0.521 0.479
E34.9 Endocrine disorder, unspecified
0.000 0.521 0.478
E25.9 Adrenogenital disorder, unspecified
0.000 0.524 0.476
E25.8 Other adrenogenital disorders
0.000 0.524 0.476
I06 Rheumatic aortic valve diseases
0.000 0.525 0.475
E31.0 Autoimmune polyglandular failure
0.000 0.527 0.473
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.528 0.472
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.528 0.472
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.528 0.471
E45 Retarded development following protein-energy malnutrition
0.000 0.528 0.471
E43 Unspecified severe protein-energy malnutrition
0.000 0.528 0.471
E42 Marasmic kwashiorkor
0.000 0.528 0.471
E41 Nutritional marasmus
0.000 0.528 0.471
E40 Kwashiorkor
0.000 0.528 0.471
I73.8 Other specified peripheral vascular diseases
0.000 0.530 0.470
I20.0 Unstable angina
0.000 0.531 0.469
E28.3 Primary ovarian failure
0.000 0.534 0.466
I09 Other rheumatic heart diseases
0.000 0.534 0.466
E31.9 Polyglandular dysfunction, unspecified
0.000 0.539 0.461
E31.8 Other polyglandular dysfunction
0.000 0.539 0.461
E31.1 Polyglandular hyperfunction
0.000 0.539 0.461
I12 Hypertensive renal disease
0.000 0.543 0.457
E34.5 Androgen resistance syndrome
0.000 0.543 0.456
E34.4 Constitutional tall stature
0.000 0.543 0.456
E34.3 Short stature, not elsewhere classified
0.000 0.543 0.456
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.543 0.456
E34.1 Other hypersecretion of intestinal hormones
0.000 0.543 0.456
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.547 0.453
E30.9 Disorder of puberty, unspecified
0.000 0.548 0.452
E30.8 Other disorders of puberty
0.000 0.548 0.452
E30.1 Precocious puberty
0.000 0.548 0.452
E30.0 Delayed puberty
0.000 0.548 0.452
E32.9 Disease of thymus, unspecified
0.000 0.548 0.452
E32.8 Other diseases of thymus
0.000 0.548 0.452
E32.1 Abscess of thymus
0.000 0.548 0.452
E32.0 Persistent hyperplasia of thymus
0.000 0.548 0.452
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.548 0.452
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.548 0.452
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.548 0.452
E20.8 Other hypoparathyroidism
0.000 0.548 0.452
E20.1 Pseudohypoparathyroidism
0.000 0.548 0.452
E20.0 Idiopathic hypoparathyroidism
0.000 0.548 0.452
E20.9 Hypoparathyroidism, unspecified
0.000 0.549 0.451
I70.00 Atherosclerosis of aorta (without gangrene)
0.000 0.553 0.447
I02 Rheumatic chorea
0.000 0.556 0.444
I01 Rheumatic fever with heart involvement
0.000 0.556 0.444
I00 Rheumatic fever without mention of heart involvement
0.000 0.559 0.440
K90.9 Intestinal malabsorption, unspecified
0.000 0.562 0.438
E24.2 Drug-induced Cushing's syndrome
0.000 0.565 0.435
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.567 0.433
I70.9 Generalised and unspecified atherosclerosis
0.000 0.572 0.427
E66 Obesity
0.000 0.574 0.426
E11.6 With other specified complications
0.000 0.575 0.424
E46 Unspecified protein-energy malnutrition
0.000 0.588 0.412
E13.8 With unspecified complications
0.000 0.590 0.410
E13.7 With multiple complications
0.000 0.590 0.410
E13.6 With other specified complications
0.000 0.590 0.410
E13.5 With peripheral circulatory complications
0.000 0.590 0.410
E13.4 With neurological complications
0.000 0.590 0.410
E13.2 With renal complications
0.000 0.590 0.410
E13.1 With ketoacidosis
0.000 0.590 0.410
E13.0 With coma
0.000 0.590 0.410
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.590 0.409
E22.8 Other hyperfunction of pituitary gland
0.000 0.590 0.409
E66.9 Obesity, unspecified
0.000 0.597 0.403
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.599 0.401
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.599 0.401
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.599 0.401
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.599 0.401
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.599 0.401
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.599 0.401
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.599 0.401
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.602 0.397
E06.5 Other chronic thyroiditis
0.000 0.607 0.393
I77.3 Arterial fibromuscular dysplasia
0.000 0.607 0.392
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.608 0.392
I70.1 Atherosclerosis of renal artery
0.000 0.609 0.391
E26.8 Other hyperaldosteronism
0.000 0.611 0.389
E26.1 Secondary hyperaldosteronism
0.000 0.611 0.389
I70.80 Atherosclerosis of other arteries (without gangrene)
0.000 0.613 0.387
E34.0 Carcinoid syndrome
0.000 0.615 0.384
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.000 0.616 0.384
I23.8 Other current complications following acute myocardial infarction
0.000 0.617 0.383
E11.4 With neurological complications
0.000 0.618 0.382
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.618 0.382
E24.3 Ectopic ACTH syndrome
0.000 0.618 0.382
E24.1 Nelson's syndrome
0.000 0.618 0.382
E24.0 Pituitary-dependent Cushing's disease
0.000 0.618 0.382
E27 Other disorders of adrenal gland
0.000 0.618 0.382
I15.0 Renovascular hypertension
0.000 0.622 0.377
I15.2 Hypertension secondary to endocrine disorders
0.000 0.623 0.377
I70.01 Atherosclerosis of aorta (with gangrene)
0.000 0.626 0.374
E06.4 Drug-induced thyroiditis
0.000 0.627 0.373
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.627 0.373
E06.0 Acute thyroiditis
0.000 0.627 0.373
I77.2 Rupture of artery
0.000 0.627 0.373
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.633 0.367
E06.1 Subacute thyroiditis
0.000 0.633 0.367
I15.1 Hypertension secondary to other renal disorders
0.000 0.637 0.363
E26.9 Hyperaldosteronism, unspecified
0.000 0.639 0.361
K90.3 Pancreatic steatorrhoea
0.000 0.640 0.360
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.640 0.360
K90.1 Tropical sprue
0.000 0.640 0.360
J45.9 Asthma, unspecified
0.000 0.641 0.359
I15.9 Seconday hypertension, unspecified
0.000 0.643 0.357
I06.0 Rheumatic aortic stenosis
0.000 0.643 0.357
E67.8 Other specified hyperalimentation
0.000 0.645 0.355
E67.3 Hypervitaminosis D
0.000 0.645 0.355
E67.2 Megavitamin-B6 syndrome
0.000 0.645 0.355
E67.1 Hypercarotenaemia
0.000 0.645 0.355
E67.0 Hypervitaminosis A
0.000 0.645 0.355
I71.3 Abdominal aortic aneurysm, ruptured
0.000 0.646 0.354
I08.9 Multiple valve disease, unspecified
0.000 0.646 0.353
I08.8 Other multiple valve diseases
0.000 0.647 0.353
E13.9 Without complications
0.000 0.649 0.351
I70.81 Atherosclerosis of other arteries (with gangrene)
0.000 0.651 0.349
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.652 0.348
K90.8 Other intestinal malabsorption
0.000 0.652 0.348
E13.3 With ophthalmic complications
0.000 0.653 0.347
I07 Rheumatic tricuspid valve diseases
0.000 0.654 0.346
I72.8 Aneurysm of other specified arteries
0.000 0.659 0.341
I06.9 Rheumatic aortic valve disease, unspecified
0.000 0.659 0.341
I06.8 Other rheumatic aortic valve diseases
0.000 0.659 0.341
I06.2 Rheumatic aortic stenosis with insufficiency
0.000 0.659 0.341
E44.1 Mild protein-energy malnutrition
0.000 0.662 0.338
E44.0 Moderate protein-energy malnutrition
0.000 0.662 0.338
E26.0 Primary hyperaldosteronism
0.000 0.662 0.338
I09.8 Other specified rheumatic heart diseases
0.000 0.666 0.334
I09.2 Chronic rheumatic pericarditis
0.000 0.666 0.334
I09.1 Rheumatic diseases of endocardium, valve unspecified
0.000 0.666 0.334
I09.0 Rheumatic myocarditis
0.000 0.666 0.334
I09.9 Rheumatic heart disease, unspecified
0.000 0.667 0.333
I06.1 Rheumatic aortic insufficiency
0.000 0.668 0.331
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.000 0.672 0.328
I12.9 Hypertensive renal disease without renal failure
0.000 0.677 0.323
I01.9 Acute rheumatic heart disease, unspecified
0.000 0.681 0.318
I01.8 Other acute rheumatic heart disease
0.000 0.681 0.318
I01.2 Acute rheumatic myocarditis
0.000 0.681 0.318
I01.1 Acute rheumatic endocarditis
0.000 0.681 0.318
I01.0 Acute rheumatic pericarditis
0.000 0.681 0.318
I02.9 Rheumatic chorea without heart involvement
0.000 0.681 0.318
I02.0 Rheumatic chorea with heart involvement
0.000 0.681 0.318
I70.2 Atherosclerosis of arteries of the extremities
0.000 0.684 0.316
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.686 0.314
E24.8 Other Cushing's syndrome
0.000 0.687 0.312
E06.3 Autoimmune thyroiditis
0.000 0.688 0.312
I15.8 Other secondary hypertension
0.000 0.689 0.311
I20.1 Angina pectoris with documented spasm
0.000 0.690 0.310
I70.91 Generalized and unspecified atherosclerosis (with gangrene)
0.000 0.693 0.306
E66.1 Drug-induced obesity
0.000 0.694 0.306
E50-E64 Other nutritional deficiencies
0.000 0.695 0.305
I20.9 Angina pectoris, unspecified
0.000 0.695 0.305
I24.1 Dressler's syndrome
0.000 0.701 0.299
I78 Diseases of capillaries
0.000 0.703 0.297
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.707 0.293
E27.9 Disorder of adrenal gland, unspecified
0.000 0.707 0.293
I70.90 Generalized and unspecified atherosclerosis (without gangrene)
0.000 0.715 0.285
E27.1 Primary adrenocortical insufficiency
0.000 0.719 0.281
I70.11 Atherosclerosis of renal artery (with gangrene)
0.000 0.719 0.280
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.000 0.720 0.280
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.723 0.277
I72.0 Aneurysm of carotid artery
0.001 0.726 0.273
E27.5 Adrenomedullary hyperfunction
0.000 0.726 0.274
E27.0 Other adrenocortical overactivity
0.000 0.726 0.274
E24.9 Cushing's syndrome, unspecified
0.000 0.729 0.271
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.733 0.267
I25 Chronic ischaemic heart disease
0.000 0.734 0.266
E22.0 Acromegaly and pituitary gigantism
0.000 0.737 0.263
E21.0 Primary hyperparathyroidism
0.000 0.737 0.263
I08.2 Disorders of both aortic and tricuspid valves
0.000 0.743 0.256
I25.5 Ischaemic cardiomyopathy
0.000 0.748 0.252
E06.9 Thyroiditis, unspecified
0.000 0.749 0.251
L40.9 Psoriasis, unspecified
0.000 0.750 0.250
I07.9 Tricuspid valve disease, unspecified
0.000 0.751 0.248
I07.8 Other tricuspid valve diseases
0.000 0.751 0.248
I07.2 Tricuspid stenosis with insufficiency
0.000 0.751 0.248
I07.0 Tricuspid stenosis
0.000 0.751 0.248
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.765 0.235
L40 Psoriasis
0.000 0.766 0.234
E51 Thiamine deficiency
0.000 0.770 0.230
I28 Other diseases of pulmonary vessels
0.000 0.776 0.224
I70.10 Atherosclerosis of renal artery (without gangrene)
0.000 0.777 0.223
I25.4 Coronary artery aneurysm
0.000 0.778 0.222
I77.8 Other specified disorders of arteries and arterioles
0.001 0.779 0.220
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.781 0.219
E50 Vitamin A deficiency
0.000 0.781 0.219
E60 Dietary zinc deficiency
0.000 0.781 0.219
E59 Dietary selenium deficiency
0.000 0.781 0.219
E54 Ascorbic acid deficiency
0.000 0.781 0.219
E52 Niacin deficiency [pellagra]
0.000 0.781 0.219
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.784 0.216
E63 Other nutritional deficiencies
0.000 0.787 0.213
I78.9 Disease of capillaries, unspecified
0.000 0.787 0.213
L40.5 Arthropathic psoriasis
0.000 0.787 0.213
I98 Other disorders of circulatory system in diseases classified elsewhere
0.000 0.790 0.210
E27.8 Other specified disorders of adrenal gland
0.000 0.790 0.210
I70.21 Atherosclerosis of arteries of extremities (with gangrene)
0.000 0.796 0.204
L40.0 Psoriasis vulgaris
0.000 0.797 0.203
I24.8 Other forms of acute ischaemic heart disease
0.000 0.797 0.202
E56 Other vitamin deficiencies
0.000 0.798 0.202
E53 Deficiency of other B group vitamins
0.000 0.799 0.201
I97.1 Other functional disturbances following cardiac surgery
0.000 0.800 0.200
E66.0 Obesity due to excess calories
0.000 0.801 0.199
E27.2 Addisonian crisis
0.000 0.809 0.191
I78.8 Other diseases of capillaries
0.000 0.809 0.191
I25.6 Silent myocardial ischaemia
0.000 0.809 0.191
E58 Dietary calcium deficiency
0.000 0.810 0.190
I97.2 Postmastectomy lymphoedema syndrome
0.000 0.810 0.190
I27 Other pulmonary heart diseases
0.000 0.811 0.188
L40.3 Pustulosis palmaris et plantaris
0.000 0.813 0.187
L40.1 Generalised pustular psoriasis
0.000 0.816 0.184
E23.0 Hypopituitarism
0.000 0.818 0.182
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.823 0.177
E51.2 Wernicke's encephalopathy
0.000 0.823 0.177
L40.8 Other psoriasis
0.000 0.825 0.175
I97.0 Postcardiotomy syndrome
0.000 0.825 0.174
I27.9 Pulmonary heart disease, unspecified
0.000 0.828 0.172
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere
0.000 0.830 0.170
L40.2 Acrodermatitis continua
0.000 0.832 0.168
E51.9 Thiamine deficiency, unspecified
0.000 0.835 0.165
E51.8 Other manifestations of thiamine deficiency
0.000 0.835 0.165
E51.1 Beriberi
0.000 0.835 0.165
L40.4 Guttate psoriasis
0.000 0.836 0.164
I25.3 Aneurysm of heart
0.000 0.836 0.163
I97.9 Postprocedural disorder of circulatory system, unspecified
0.000 0.838 0.162
E53.8 Deficiency of other specified B group vitamins
0.000 0.838 0.162
I28.9 Disease of pulmonary vessels, unspecified
0.000 0.839 0.161
I28.1 Aneurysm of pulmonary artery
0.000 0.839 0.161
I28.0 Arteriovenous fistula of pulmonary vessels
0.000 0.839 0.161
E50.9 Vitamin A deficiency, unspecified
0.000 0.843 0.157
E50.8 Other manifestations of vitamin A deficiency
0.000 0.843 0.157
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.843 0.157
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.843 0.157
E50.5 Vitamin A deficiency with night blindness
0.000 0.843 0.157
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.843 0.157
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.843 0.157
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.843 0.157
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.843 0.157
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.843 0.157
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.843 0.157
E64.8 Sequelae of other nutritional deficiencies
0.000 0.843 0.157
E64.3 Sequelae of rickets
0.000 0.843 0.157
E64.2 Sequelae of vitamin C deficiency
0.000 0.843 0.157
E64.1 Sequelae of vitamin A deficiency
0.000 0.843 0.157
E64.0 Sequelae of protein-energy malnutrition
0.000 0.843 0.157
I05 Rheumatic mitral valve diseases
0.000 0.844 0.156
E61 Deficiency of other nutrient elements
0.000 0.846 0.154
E63.8 Other specified nutritional deficiencies
0.000 0.847 0.153
E63.1 Imbalance of constituents of food intake
0.000 0.847 0.153
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.847 0.153
I12.0 Hypertensive renal disease with renal failure
0.000 0.848 0.152
I98.8 Other specified disorders of circulatory system in diseases classified elsewhere
0.000 0.849 0.151
I98.1 Cardiovascular disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.849 0.151
I98.0 Cardiovascular syphilis
0.000 0.849 0.151
I77.6 Arteritis, unspecified
0.001 0.850 0.149
I28.8 Other specified diseases of pulmonary vessels
0.000 0.851 0.149
I78.0 Hereditary haemorrhagic telangiectasia
0.000 0.851 0.149
E63.9 Nutritional deficiency, unspecified
0.000 0.853 0.147
E55 Vitamin D deficiency
0.000 0.854 0.146
E56.9 Vitamin deficiency, unspecified
0.000 0.855 0.145
E56.8 Deficiency of other vitamins
0.000 0.855 0.145
E56.0 Deficiency of vitamin E
0.000 0.855 0.145
E53.1 Pyridoxine deficiency
0.000 0.855 0.144
E53.0 Riboflavin deficiency
0.000 0.855 0.144
I95 Hypotension
0.000 0.856 0.144
I27.8 Other specified pulmonary heart diseases
0.000 0.857 0.143
I21 Acute myocardial infarction
0.000 0.859 0.141
I70.20 Atherosclerosis of arteries of extremities (without gangrene)
0.000 0.861 0.139
I27.1 Kyphoscoliotic heart disease
0.000 0.865 0.135
I20.8 Other forms of angina pectoris
0.000 0.868 0.132
E04 Other non-toxic goitre
0.000 0.872 0.128
E56.1 Deficiency of vitamin K
0.000 0.872 0.128
I07.1 Tricuspid insufficiency
0.000 0.872 0.127
I25.1 Atherosclerotic heart disease
0.000 0.873 0.127
I21.4 Acute subendocardial myocardial infarction
0.000 0.877 0.123
I95.1 Orthostatic hypotension
0.000 0.878 0.122
I95.2 Hypotension due to drugs
0.000 0.879 0.121
I99 Other and unspecified disorders of circulatory system
0.000 0.883 0.116
E61.9 Deficiency of nutrient element, unspecified
0.000 0.889 0.110
E61.8 Deficiency of other specified nutrient elements
0.000 0.889 0.110
E61.7 Deficiency of multiple nutrient elements
0.000 0.889 0.110
E61.6 Vanadium deficiency
0.000 0.889 0.110
E61.5 Molybdenum deficiency
0.000 0.889 0.110
E61.4 Chromium deficiency
0.000 0.889 0.110
E61.3 Manganese deficiency
0.000 0.889 0.110

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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