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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs112971323
log Bayes Factor = 15.7014
Chromosome 11   position 111,697,513  (GRCh37) Explore rs112971323 on Ensembl!
Variant rs112971323 is part of Cluster X0093

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
I25 Chronic ischaemic heart disease
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
I25.2 Old myocardial infarction
1.000 0.000 0.000
I20-I25 Ischaemic heart diseases
1.000 0.000 0.000
I30-I52 Other forms of heart disease
0.999 0.001 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.993 0.007 0.000
Chapter I Certain infectious and parasitic diseases
0.992 0.008 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.990 0.010 0.000
I25.1 Atherosclerotic heart disease
0.988 0.012 0.000
B95-B98 Bacterial, viral and other infectious agents
0.984 0.016 0.000
I25.8 Other forms of chronic ischaemic heart disease
0.983 0.017 0.000
E10-E14 Diabetes mellitus
0.981 0.019 0.000
B96 Other bacterial agents as the cause of diseases classified to other chapters
0.975 0.025 0.000
I25.9 Chronic ischaemic heart disease, unspecified
0.966 0.034 0.000
Z95 Presence of cardiac and vascular implants and grafts
0.964 0.036 0.000
Z95.5 Presence of coronary angioplasty implant and graft
0.960 0.040 0.000
I35 Nonrheumatic aortic valve disorders
0.957 0.043 0.000
B96.5 Pseudomonas (aeruginosa)(mallei)(pseudomallei) as the cause of diseases classified to other chapters
0.952 0.048 0.000
Chapter X Diseases of the respiratory system
0.947 0.053 0.000
Chapter VIII Diseases of the ear and mastoid process
0.945 0.055 0.000
I20 Angina pectoris
0.943 0.057 0.000
I44 Atrioventricular and left bundle-branch block
0.941 0.059 0.000
E11 Non-insulin-dependent diabetes mellitus
0.939 0.061 0.000
I42 Cardiomyopathy
0.930 0.070 0.000
I50 Heart failure
0.920 0.080 0.000
E10 Insulin-dependent diabetes mellitus
0.920 0.080 0.000
I73 Other peripheral vascular diseases
0.919 0.081 0.000
Z95.1 Presence of aortocoronary bypass graft
0.918 0.082 0.000
Chapter XX External causes of morbidity and mortality
0.918 0.082 0.000
I35.0 Aortic (valve) stenosis
0.917 0.083 0.000
Chapter XXI Factors influencing health status and contact with health services
0.912 0.088 0.000
J40-J47 Chronic lower respiratory diseases
0.907 0.093 0.000
Z95.2 Presence of prosthetic heart valve
0.901 0.099 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.901 0.099 0.000
I45 Other conduction disorders
0.900 0.100 0.000
I25.3 Aneurysm of heart
0.893 0.107 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.892 0.108 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.887 0.113 0.000
I73.9 Peripheral vascular disease, unspecified
0.885 0.115 0.000
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status
0.883 0.117 0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters
0.879 0.121 0.000
Chapter XXII Codes for special purposes
0.879 0.121 0.000
B96.3 Haemophilus influenzae [H. influenzae] as the cause of diseases classified to other chapters
0.874 0.126 0.000
H90-H95 Other disorders of ear
0.872 0.128 0.000
E11.3 With ophthalmic complications
0.872 0.128 0.000
I21 Acute myocardial infarction
0.868 0.132 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.862 0.138 0.000
I50.1 Left ventricular failure
0.858 0.142 0.000
B96.4 Proteus (mirabilis)(morganii) as the cause of diseases classified to other chapters
0.856 0.144 0.000
B95.6 Staphylococcus aureus as the cause of diseases classified to other chapters
0.852 0.148 0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases
0.847 0.153 0.000
Z95.3 Presence of xenogenic heart valve
0.844 0.156 0.000
Y40 Systemic antibiotics
0.843 0.157 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.840 0.160 0.000
I44.1 Atrioventricular block, second degree
0.840 0.160 0.000
I72 Other aneurysm
0.838 0.162 0.000
J44 Other chronic obstructive pulmonary disease
0.837 0.163 0.000
I20.9 Angina pectoris, unspecified
0.836 0.164 0.000
E10.3 With ophthalmic complications
0.832 0.168 0.000
I44.7 Left bundle-branch block, unspecified
0.830 0.170 0.000
J47 Bronchiectasis
0.829 0.171 0.000
B15-B19 Viral hepatitis
0.827 0.173 0.000
Chapter XI Diseases of the digestive system
0.825 0.175 0.000
H90 Conductive and sensorineural hearing loss
0.825 0.175 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.824 0.176 0.000
I22 Subsequent myocardial infarction
0.823 0.177 0.000
K20-K31 Diseases of oesophagus, stomach and duodenum
0.822 0.178 0.000
E70-E90 Metabolic disorders
0.821 0.179 0.000
M15-M19 Arthrosis
0.815 0.185 0.000
I70 Atherosclerosis
0.815 0.185 0.000
I77 Other disorders of arteries and arterioles
0.813 0.187 0.000
K22 Other diseases of oesophagus
0.812 0.188 0.000
I36 Nonrheumatic tricuspid valve disorders
0.812 0.188 0.000
Z89 Acquired absence of limb
0.811 0.189 0.000
Z95.0 Presence of cardiac pacemaker
0.811 0.189 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
0.810 0.190 0.000
I20.0 Unstable angina
0.807 0.193 0.000
Y40.0 Penicillins
0.806 0.194 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.805 0.195 0.000
I42.0 Dilated cardiomyopathy
0.803 0.197 0.000
K29 Gastritis and duodenitis
0.803 0.197 0.000
I71 Aortic aneurysm and dissection
0.801 0.199 0.000
I05-I09 Chronic rheumatic heart diseases
0.799 0.201 0.000
I31 Other diseases of pericardium
0.798 0.202 0.000
E11.5 With peripheral circulatory complications
0.796 0.204 0.000
Z22 Carrier of infectious disease
0.796 0.204 0.000
M17 Gonarthrosis [arthrosis of knee]
0.794 0.206 0.000
H65-H75 Diseases of middle ear and mastoid
0.793 0.207 0.000
Z98 Other postsurgical states
0.791 0.209 0.000
E20-E35 Disorders of other endocrine glands
0.791 0.209 0.000
K22.7 Barrett's oesophagus
0.790 0.210 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.788 0.212 0.000
E10.5 With peripheral circulatory complications
0.788 0.212 0.000
B99-B99 Other infectious diseases
0.786 0.214 0.000
Z95.8 Presence of other cardiac and vascular implants and grafts
0.786 0.214 0.000
I44.2 Atrioventricular block, complete
0.785 0.215 0.000
I42.1 Obstructive hypertrophic cardiomyopathy
0.784 0.215 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.784 0.216 0.000
M17.9 Gonarthrosis, unspecified
0.784 0.216 0.000
Z95.4 Presence of other heart-valve replacement
0.783 0.217 0.000
I51 Complications and ill-defined descriptions of heart disease
0.780 0.220 0.000
I45.1 Other and unspecified right bundle-branch block
0.777 0.223 0.000
E14 Unspecified diabetes mellitus
0.776 0.224 0.000
L03 Cellulitis
0.775 0.225 0.000
I35.2 Aortic (valve) stenosis with insufficiency
0.775 0.225 0.000
K29.7 Gastritis, unspecified
0.775 0.225 0.000
E11.4 With neurological complications
0.775 0.225 0.000
B96.2 Escherichia coli [E. coli] as the cause of diseases classified to other chapters
0.774 0.226 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.773 0.227 0.000
J30-J39 Other diseases of upper respiratory tract
0.773 0.227 0.000
J44.8 Other specified chronic obstructive pulmonary disease
0.770 0.230 0.000
L03.1 Cellulitis of other parts of limb
0.770 0.230 0.000
I78 Diseases of capillaries
0.769 0.230 0.000
J00-J06 Acute upper respiratory infections
0.769 0.230 0.000
L97 Ulcer of lower limb, not elsewhere classified
0.768 0.232 0.000
I25.5 Ischaemic cardiomyopathy
0.768 0.232 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.768 0.232 0.000
J38 Diseases of vocal cords and larynx, not elsewhere classified
0.767 0.233 0.000
I20.8 Other forms of angina pectoris
0.766 0.234 0.000
M19 Other arthrosis
0.766 0.234 0.000
E10.4 With neurological complications
0.764 0.236 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.761 0.239 0.000
I74 Arterial embolism and thrombosis
0.759 0.241 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.759 0.241 0.000
L20-L30 Dermatitis and eczema
0.758 0.242 0.000
H60-H62 Diseases of external ear
0.757 0.243 0.000
Chapter VII Diseases of the eye and adnexa
0.753 0.247 0.000
E65-E68 Obesity and other hyperalimentation
0.752 0.248 0.000
I35.8 Other aortic valve disorders
0.748 0.252 0.000
Z95.9 Presence of cardiac and vascular implant and graft, unspecified
0.745 0.255 0.000
Z22.3 Carrier of other specified bacterial diseases
0.745 0.255 0.000
I38 Endocarditis, valve unspecified
0.744 0.256 0.000
D50-D53 Nutritional anaemias
0.743 0.257 0.000
I21.0 Acute transmural myocardial infarction of anterior wall
0.740 0.260 0.000
K29.8 Duodenitis
0.739 0.261 0.000
Z99 Dependence on enabling machines and devices, not elsewhere classified
0.737 0.263 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.734 0.266 0.000
E11.0 With coma
0.732 0.268 0.000
E11.6 With other specified complications
0.731 0.269 0.000
I21.9 Acute myocardial infarction, unspecified
0.731 0.269 0.000
I42.8 Other cardiomyopathies
0.730 0.270 0.000
Z98.0 Intestinal bypass and anastomosis status
0.729 0.271 0.000
E83 Disorders of mineral metabolism
0.728 0.272 0.000
D69 Purpura and other haemorrhagic conditions
0.725 0.275 0.000
J90-J94 Other diseases of pleura
0.725 0.275 0.000
E13 Other specified diabetes mellitus
0.724 0.276 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.724 0.276 0.000
K31 Other diseases of stomach and duodenum
0.721 0.279 0.000
H92 Otalgia and effusion of ear
0.721 0.279 0.000
H30-H36 Disorders of choroid and retina
0.721 0.279 0.000
Z13.0 Special screening examination for diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.721 0.279 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.720 0.280 0.000
X60-X84 Intentional self-harm
0.719 0.281 0.000
M86-M90 Other osteopathies
0.719 0.281 0.000
Z00-Z13 Persons encountering health services for examination and investigation
0.718 0.282 0.000
I45.5 Other specified heart block
0.718 0.282 0.000
I25.6 Silent myocardial ischaemia
0.717 0.283 0.000
I25.4 Coronary artery aneurysm
0.717 0.283 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.717 0.283 0.000
I23 Certain current complications following acute myocardial infarction
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
I52 Other heart disorders in diseases classified elsewhere
0.717 0.283 0.000
I48 Atrial fibrillation and flutter
0.717 0.283 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.717 0.283 0.000
I41 Myocarditis in diseases classified elsewhere
0.717 0.283 0.000
I40 Acute myocarditis
0.717 0.283 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.717 0.283 0.000
I37 Pulmonary valve disorders
0.717 0.283 0.000
I32 Pericarditis in diseases classified elsewhere
0.717 0.283 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.713 0.287 0.000
I45.6 Preexcitation syndrome
0.712 0.288 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.711 0.288 0.000
B65-B83 Helminthiases
0.711 0.288 0.000
B50-B64 Protozoal diseases
0.711 0.288 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.711 0.288 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.711 0.288 0.000
A80-A89 Viral infections of the central nervous system
0.711 0.288 0.000
A75-A79 Rickettsioses
0.711 0.288 0.000
A70-A74 Other diseases caused by chlamydiae
0.711 0.288 0.000
A65-A69 Other spirochaetal diseases
0.711 0.288 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.711 0.288 0.000
A20-A28 Certain zoonotic bacterial diseases
0.711 0.288 0.000
A15-A19 Tuberculosis
0.711 0.288 0.000
Z89.5 Acquired absence of leg at or below knee
0.711 0.289 0.000
E11.1 With ketoacidosis
0.710 0.289 0.000
Z13 Special screening examination for other diseases and disorders
0.710 0.290 0.000
J38.7 Other diseases of larynx
0.710 0.290 0.000
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection
0.710 0.290 0.000
K29.3 Chronic superficial gastritis
0.710 0.290 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.708 0.292 0.000
J95-J99 Other diseases of the respiratory system
0.708 0.292 0.000
E40-E46 Malnutrition
0.708 0.292 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.708 0.292 0.000
Chapter V Mental and behavioural disorders
0.707 0.293 0.000
I35.9 Aortic valve disorder, unspecified
0.706 0.294 0.000
E12 Malnutrition-related diabetes mellitus
0.703 0.296 0.000
J38.3 Other diseases of vocal cords
0.703 0.297 0.000
Z89.6 Acquired absence of leg above knee
0.701 0.299 0.000
M19.9 Arthrosis, unspecified
0.701 0.299 0.000
B96.7 Clostridium perfringens [C. perfringens] as the cause of diseases classified to other chapters
0.699 0.301 0.000
B96.6 Bacillus fragilis [B. fragilis] as the cause of diseases classified to other chapters
0.699 0.301 0.000
B96.0 Mycoplasma pneumoniae [M. pneumoniae] as the cause of diseases classified to other chapters
0.699 0.301 0.000
I42.2 Other hypertrophic cardiomyopathy
0.699 0.301 0.000
E50-E64 Other nutritional deficiencies
0.698 0.302 0.000
Y52 Agents primarily affecting the cardiovascular system
0.697 0.303 0.000
H65 Nonsuppurative otitis media
0.696 0.304 0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs
0.695 0.305 0.000
Z93 Artificial opening status
0.695 0.305 0.000
D51 Vitamin B12 deficiency anaemia
0.694 0.306 0.000
L81 Other disorders of pigmentation
0.692 0.308 0.000
I30 Acute pericarditis
0.692 0.308 0.000
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.692 0.308 0.000
M19.99 Arthrosis, unspecified (Site unspecified)
0.691 0.309 0.000
K29.0 Acute haemorrhagic gastritis
0.690 0.310 0.000
H90.1 Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
0.689 0.311 0.000
B25-B34 Other viral diseases
0.689 0.311 0.000
B35-B49 Mycoses
0.688 0.312 0.000
M17.0 Primary gonarthrosis, bilateral
0.688 0.312 0.000
Z70-Z76 Persons encountering health services in other circumstances
0.688 0.312 0.000
K25 Gastric ulcer
0.684 0.316 0.000
H90.3 Sensorineural hearing loss, bilateral
0.684 0.316 0.000
I50.0 Congestive heart failure
0.684 0.316 0.000
I46 Cardiac arrest
0.683 0.317 0.000
J90 Pleural effusion, not elsewhere classified
0.683 0.317 0.000
K22.9 Disease of oesophagus, unspecified
0.682 0.318 0.000
E11.2 With renal complications
0.682 0.318 0.000
K40-K46 Hernia
0.682 0.318 0.000
B96.1 Klebsiella pneumoniae [K. pneumoniae] as the cause of diseases classified to other chapters
0.680 0.320 0.000
H90.2 Conductive hearing loss, unspecified
0.678 0.322 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.678 0.322 0.000
I36.1 Nonrheumatic tricuspid (valve) insufficiency
0.677 0.322 0.000
K22.1 Ulcer of oesophagus
0.677 0.323 0.000
L83 Acanthosis nigricans
0.677 0.323 0.000
V10-V19 Pedal cyclist injured in transport accident
0.676 0.324 0.000
B95.3 Streptococcus pneumoniae as the cause of diseases classified to other chapters
0.675 0.325 0.000
I44.6 Other and unspecified fascicular block
0.675 0.325 0.000
I44.5 Left posterior fascicular block
0.675 0.325 0.000
I44.4 Left anterior fascicular block
0.675 0.325 0.000
I44.3 Other and unspecified atrioventricular block
0.675 0.325 0.000
Q80-Q89 Other congenital malformations
0.674 0.325 0.000
B17 Other acute viral hepatitis
0.674 0.326 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.674 0.326 0.000
E11.8 With unspecified complications
0.673 0.327 0.000
E11.7 With multiple complications
0.673 0.327 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.672 0.328 0.000
E83.1 Disorders of iron metabolism
0.671 0.329 0.000
H90.5 Sensorineural hearing loss, unspecified
0.670 0.330 0.000
Q60-Q64 Congenital malformations of the urinary system
0.669 0.331 0.000
D68 Other coagulation defects
0.668 0.332 0.000
I42.7 Cardiomyopathy due to drugs and other external agents
0.667 0.333 0.000
I42.6 Alcoholic cardiomyopathy
0.667 0.333 0.000
I42.5 Other restrictive cardiomyopathy
0.667 0.333 0.000
I42.4 Endocardial fibroelastosis
0.667 0.333 0.000
I42.3 Endomyocardial (eosinophilic) disease
0.667 0.333 0.000
I51.8 Other ill-defined heart diseases
0.666 0.334 0.000
J39 Other diseases of upper respiratory tract
0.666 0.334 0.000
J46 Status asthmaticus
0.665 0.335 0.000
E27 Other disorders of adrenal gland
0.664 0.336 0.000
I22.9 Subsequent myocardial infarction of unspecified site
0.664 0.336 0.000
I72.3 Aneurysm of iliac artery
0.663 0.337 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.663 0.337 0.000
J40 Bronchitis, not specified as acute or chronic
0.662 0.338 0.000
I47 Paroxysmal tachycardia
0.660 0.340 0.000
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.660 0.340 0.000
E10.8 With unspecified complications
0.659 0.341 0.000
E10.7 With multiple complications
0.659 0.341 0.000
E10.6 With other specified complications
0.659 0.341 0.000
E10.2 With renal complications
0.659 0.341 0.000
E10.0 With coma
0.659 0.341 0.000
I73.8 Other specified peripheral vascular diseases
0.659 0.341 0.000
I73.1 Thromboangiitis obliterans [Buerger]
0.659 0.341 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.658 0.342 0.000
Y35-Y36 Legal intervention and operations of war
0.658 0.342 0.000
Y10-Y34 Event of undetermined intent
0.658 0.342 0.000
Y00-Y09 Assault
0.658 0.342 0.000
X85-X99 Assault
0.658 0.342 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.658 0.342 0.000
X50-X57 Overexertion, travel and privation
0.658 0.342 0.000
X30-X39 Exposure to forces of nature
0.658 0.342 0.000
X20-X29 Contact with venomous animals and plants
0.658 0.342 0.000
X10-X19 Contact with heat and hot substances
0.658 0.342 0.000
X00-X09 Exposure to smoke, fire and flames
0.658 0.342 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.658 0.342 0.000
W75-W84 Other accidental threats to breathing
0.658 0.342 0.000
W65-W74 Accidental drowning and submersion
0.658 0.342 0.000
W50-W64 Exposure to animate mechanical forces
0.658 0.342 0.000
V98-V99 Other and unspecified transport accidents
0.658 0.342 0.000
V95-V97 Air and space transport accidents
0.658 0.342 0.000
V90-V94 Water transport accidents
0.658 0.342 0.000
V80-V89 Other land transport accidents
0.658 0.342 0.000
V70-V79 Bus occupant injured in transport accident
0.658 0.342 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.658 0.342 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.658 0.342 0.000
V40-V49 Car occupant injured in transport accident
0.658 0.342 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.658 0.342 0.000
V01-V09 Pedestrian injured in transport accident
0.658 0.342 0.000
U80 Agent resistant to penicillin and related antibiotics
0.658 0.342 0.000
I77.9 Disorder of arteries and arterioles, unspecified
0.657 0.343 0.000
I33 Acute and subacute endocarditis
0.657 0.343 0.000
Chapter II Neoplasms
0.656 0.344 0.000
I77.8 Other specified disorders of arteries and arterioles
0.656 0.344 0.000
I50.9 Heart failure, unspecified
0.655 0.345 0.000
J43 Emphysema
0.655 0.345 0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.655 0.345 0.000
H35 Other retinal disorders
0.654 0.346 0.000
O60-O75 Complications of labour and delivery
0.654 0.346 0.000
Q50-Q56 Congenital malformations of genital organs
0.653 0.347 0.000
L89 Decubitus ulcer
0.652 0.348 0.000
J38.2 Nodules of vocal cords
0.652 0.348 0.000
D66 Hereditary factor VIII deficiency
0.651 0.349 0.000
D80-D89 Certain disorders involving the immune mechanism
0.650 0.350 0.000
J41 Simple and mucopurulent chronic bronchitis
0.650 0.350 0.000
I72.8 Aneurysm of other specified arteries
0.650 0.350 0.000
Z94 Transplanted organ and tissue status
0.649 0.351 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.649 0.351 0.000
I42.9 Cardiomyopathy, unspecified
0.648 0.352 0.000
I72.4 Aneurysm of artery of lower extremity
0.648 0.352 0.000
J20-J22 Other acute lower respiratory infections
0.648 0.352 0.000
E88 Other metabolic disorders
0.647 0.353 0.000
I70.0 Atherosclerosis of aorta
0.647 0.353 0.000
I20.1 Angina pectoris with documented spasm
0.646 0.354 0.000
L10-L14 Bullous disorders
0.646 0.354 0.000
B18 Chronic viral hepatitis
0.646 0.354 0.000
I45.8 Other specified conduction disorders
0.646 0.354 0.000
I45.4 Nonspecific intraventricular block
0.646 0.354 0.000
I45.3 Trifascicular block
0.646 0.354 0.000
I45.2 Bifascicular block
0.646 0.354 0.000
I45.0 Right fascicular block
0.646 0.354 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.645 0.355 0.000
Y40.8 Other systemic antibiotics
0.644 0.356 0.000
H36 Retinal disorders in diseases classified elsewhere
0.644 0.356 0.000
H66 Suppurative and unspecified otitis media
0.644 0.356 0.000
I71.3 Abdominal aortic aneurysm, ruptured
0.643 0.356 0.000
Z09 Follow-up examination after treatment for conditions other than malignant neoplasms
0.643 0.357 0.000
M00-M03 Infectious arthropathies
0.643 0.357 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.642 0.358 0.000
M19.96 Arthrosis, unspecified-Lower leg
0.642 0.358 0.000
W00-W19 Falls
0.642 0.358 0.000
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.641 0.358 0.000
Z99.2 Dependence on renal dialysis
0.641 0.359 0.000
A30-A49 Other bacterial diseases
0.641 0.359 0.000
I70.2 Atherosclerosis of arteries of the extremities
0.641 0.359 0.000
D55-D59 Haemolytic anaemias
0.639 0.360 0.000
M19.0 Primary arthrosis of other joints
0.639 0.361 0.000
Z81 Family history of mental and behavioural disorders
0.639 0.361 0.000
L85 Other epidermal thickening
0.638 0.362 0.000
B99 Other and unspecified infectious diseases
0.637 0.362 0.000
Y59 Other and unspecified vaccines and biological substances
0.636 0.364 0.000
Y58 Bacterial vaccines
0.636 0.364 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.636 0.364 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.636 0.364 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.636 0.364 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.636 0.364 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.636 0.364 0.000
Y48 Anaesthetics and therapeutic gases
0.636 0.364 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.636 0.364 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.636 0.364 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.636 0.364 0.000
I22.1 Subsequent myocardial infarction of inferior wall
0.636 0.364 0.000
L93 Lupus erythematosus
0.636 0.364 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.635 0.365 0.000
B95.7 Other staphylococcus as the cause of diseases classified to other chapters
0.635 0.365 0.000
Z22.5 Carrier of viral hepatitis
0.634 0.366 0.000
Z84 Family history of other conditions
0.633 0.367 0.000
K22.4 Dyskinesia of oesophagus
0.632 0.368 0.000
B95.2 Streptococcus, group D, as the cause of diseases classified to other chapters
0.630 0.369 0.000
B95.0 Streptococcus, group A, as the cause of diseases classified to other chapters
0.630 0.369 0.000
L29 Pruritus
0.630 0.370 0.000
Y44 Agents primarily affecting blood constituents
0.630 0.370 0.000
E65 Localised adiposity
0.629 0.371 0.000
Z29 Need for other prophylactic measures
0.629 0.371 0.000
K42 Umbilical hernia
0.629 0.371 0.000
J03 Acute tonsillitis
0.628 0.371 0.000
V20-V29 Motorcycle rider injured in transport accident
0.626 0.373 0.000
H95 Postprocedural disorders of ear and mastoid process, not elsewhere classified
0.625 0.374 0.000
H94 Other disorders of ear in diseases classified elsewhere
0.625 0.374 0.000
M91-M94 Chondropathies
0.625 0.375 0.000
Y49.2 Other and unspecified antidepressants
0.625 0.375 0.000
I45.9 Conduction disorder, unspecified
0.624 0.376 0.000
B00 Herpesviral [herpes simplex] infections
0.624 0.376 0.000
J86 Pyothorax
0.624 0.376 0.000
I21.4 Acute subendocardial myocardial infarction
0.623 0.377 0.000
I31.9 Disease of pericardium, unspecified
0.623 0.377 0.000
L81.4 Other melanin hyperpigmentation
0.623 0.377 0.000
I51.7 Cardiomegaly
0.622 0.377 0.000
Z09.9 Follow-up examination after unspecified treatment for other conditions
0.622 0.378 0.000
I21.X Presumed acute myicardial infaction (unconfirmed)
0.622 0.378 0.000
I21.3 Acute transmural myocardial infarction of unspecified site
0.622 0.378 0.000
J05 Acute obstructive laryngitis [croup] and epiglottitis
0.622 0.378 0.000
H61 Other disorders of external ear
0.622 0.378 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.622 0.378 0.000
K21 Gastro-oesophageal reflux disease
0.621 0.379 0.000
B01 Varicella [chickenpox]
0.619 0.381 0.000
K70-K77 Diseases of liver
0.619 0.381 0.000
B98 Other specified infectious agents as the cause of diseases classified to other chapters
0.618 0.382 0.000
J38.0 Paralysis of vocal cords and larynx
0.618 0.382 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.618 0.382 0.000
Q35-Q37 Cleft lip and cleft palate
0.618 0.382 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.618 0.382 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.618 0.382 0.000
I08 Multiple valve diseases
0.618 0.382 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.617 0.383 0.000
H10-H13 Disorders of conjunctiva
0.615 0.385 0.000
B95.5 Unspecified streptococcus as the cause of diseases classified to other chapters
0.614 0.386 0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.614 0.386 0.000
K31.8 Other specified diseases of stomach and duodenum
0.614 0.386 0.000
Z75 Problems related to medical facilities and other health care
0.613 0.387 0.000
D69.6 Thrombocytopenia, unspecified
0.613 0.387 0.000
H71 Cholesteatoma of middle ear
0.613 0.387 0.000
Z83 Family history of other specific disorders
0.613 0.387 0.000
O75 Other complications of labour and delivery, not elsewhere classified
0.613 0.387 0.000
K22.0 Achalasia of cardia
0.612 0.387 0.000
J42 Unspecified chronic bronchitis
0.612 0.388 0.000
I31.3 Pericardial effusion (noninflammatory)
0.612 0.388 0.000
L50-L54 Urticaria and erythema
0.611 0.388 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.611 0.389 0.000
I78.1 Naevus, nonneoplastic
0.610 0.390 0.000
M45-M49 Spondylopathies
0.609 0.391 0.000
L27 Dermatitis due to substances taken internally
0.608 0.392 0.000
B91 Sequelae of poliomyelitis
0.607 0.392 0.000
Z28 Immunisation not carried out
0.607 0.393 0.000
Z27 Need for immunisation against combinations of infectious diseases
0.607 0.393 0.000
Z26 Need for immunisation against other single infectious diseases
0.607 0.393 0.000
Z25 Need for immunisation against other single viral diseases
0.607 0.393 0.000
Z24 Need for immunisation against certain single viral diseases
0.607 0.393 0.000
Z23 Need for immunisation against single bacterial diseases
0.607 0.393 0.000
Z20 Contact with and exposure to communicable diseases
0.607 0.393 0.000
Z21 Asymptomatic human immunodeficiency virus [HIV] infection status
0.607 0.393 0.000
I07 Rheumatic tricuspid valve diseases
0.607 0.393 0.000
H65.3 Chronic mucoid otitis media
0.607 0.393 0.000
H34 Retinal vascular occlusions
0.605 0.395 0.000
Y40.7 Antifungal antibiotics, systemically used
0.604 0.396 0.000
Y40.6 Rifamycins
0.604 0.396 0.000
Y40.5 Aminoglycosides
0.604 0.396 0.000
Y40.4 Tetracyclines
0.604 0.396 0.000
Y40.3 Macrolides
0.604 0.396 0.000
Y40.2 Chloramphenicol group
0.604 0.396 0.000
Y40.1 Cefalosporins and other -lactam antibiotics
0.604 0.396 0.000
J09-J18 Influenza and pneumonia
0.603 0.397 0.000
M60-M63 Disorders of muscles
0.602 0.397 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.601 0.399 0.000
Z93.0 Tracheostomy status
0.601 0.399 0.000
Q00-Q07 Congenital malformations of the nervous system
0.601 0.399 0.000
I72.9 Aneurysm of unspecified site
0.601 0.399 0.000
I72.6 Aneurysm and dissection of vertebral artery
0.601 0.399 0.000
I72.5 Aneurysm and dissection of other precerebral arteries
0.601 0.399 0.000
I72.2 Aneurysm of renal artery
0.601 0.399 0.000
I72.1 Aneurysm of artery of upper extremity
0.601 0.399 0.000
I72.0 Aneurysm of carotid artery
0.601 0.399 0.000
K29.2 Alcoholic gastritis
0.600 0.400 0.000
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.600 0.400 0.000
E14.9 Without complications
0.600 0.400 0.000
W20-W49 Exposure to inanimate mechanical forces
0.596 0.404 0.000
H92.1 Otorrhoea
0.596 0.404 0.000
D69.3 Idiopathic thrombocytopenic purpura
0.595 0.405 0.000
D00-D09 In situ neoplasms
0.595 0.405 0.000
I95 Hypotension
0.595 0.405 0.000
L84 Corns and callosities
0.594 0.406 0.000
B19 Unspecified viral hepatitis
0.593 0.407 0.000
B16 Acute hepatitis B
0.593 0.407 0.000
B15 Acute hepatitis A
0.593 0.407 0.000
K22.6 Gastro-oesophageal laceration-haemorrhage syndrome
0.593 0.407 0.000
M65-M68 Disorders of synovium and tendon
0.592 0.408 0.000
Y40.9 Systemic antibiotic, unspecified
0.592 0.408 0.000
E14.3 With ophthalmic complications
0.592 0.408 0.000
H90.8 Mixed conductive and sensorineural hearing loss, unspecified
0.591 0.408 0.000
H90.7 Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
0.591 0.408 0.000
H90.6 Mixed conductive and sensorineural hearing loss, bilateral
0.591 0.408 0.000
H90.4 Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
0.591 0.408 0.000
H90.0 Conductive hearing loss, bilateral
0.591 0.408 0.000
K31.1 Adult hypertrophic pyloric stenosis
0.591 0.409 0.000
D67 Hereditary factor IX deficiency
0.591 0.409 0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.591 0.409 0.000
I22.8 Subsequent myocardial infarction of other sites
0.590 0.410 0.000
I22.0 Subsequent myocardial infarction of anterior wall
0.590 0.410 0.000
K28 Gastrojejunal ulcer
0.590 0.410 0.000
K23 Disorders of oesophagus in diseases classified elsewhere
0.590 0.410 0.000
H36.0 Diabetic retinopathy
0.589 0.411 0.000
I21.2 Acute transmural myocardial infarction of other sites
0.589 0.411 0.000
J39.2 Other diseases of pharynx
0.589 0.411 0.000
E85 Amyloidosis
0.589 0.411 0.000
E84 Cystic fibrosis
0.589 0.411 0.000
E79 Disorders of purine and pyrimidine metabolism
0.589 0.411 0.000
E77 Disorders of glycoprotein metabolism
0.589 0.411 0.000
E76 Disorders of glycosaminoglycan metabolism
0.589 0.411 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.589 0.411 0.000
E74 Other disorders of carbohydrate metabolism
0.589 0.411 0.000
E73 Lactose intolerance
0.589 0.411 0.000
E72 Other disorders of amino-acid metabolism
0.589 0.411 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.589 0.411 0.000
E70 Disorders of aromatic amino-acid metabolism
0.589 0.411 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.589 0.411 0.000
E10.1 With ketoacidosis
0.588 0.412 0.000
K31.4 Gastric diverticulum
0.588 0.412 0.000
Z98.1 Arthrodesis status
0.588 0.412 0.000
Y51.7 Beta-Adrenoreceptor antagonists, not elsewhere classified
0.588 0.412 0.000
Y86 Sequelae of other accidents
0.587 0.413 0.000
I05 Rheumatic mitral valve diseases
0.586 0.414 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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