TreeWAS – Variant ID: rs114846446

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability
# Top node	1.000	0.000
Chapter IX Diseases of the circulatory system	1.000	0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	0.999	0.001
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.999	0.001
I20-I25 Ischaemic heart diseases	0.999	0.001
M05-M14 Inflammatory polyarthropathies	0.998	0.002
M06 Other rheumatoid arthritis	0.998	0.002
M06.9 Rheumatoid arthritis, unspecified	0.997	0.003
Chapter IV Endocrine, nutritional and metabolic diseases	0.997	0.003
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue	0.996	0.004
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.996	0.004
I25 Chronic ischaemic heart disease	0.992	0.008
I25.9 Chronic ischaemic heart disease, unspecified	0.986	0.014
R21 Rash and other nonspecific skin eruption	0.981	0.019
I20 Angina pectoris	0.979	0.021
E70-E90 Metabolic disorders	0.978	0.022
E65-E68 Obesity and other hyperalimentation	0.977	0.023
E87 Other disorders of fluid, electrolyte and acid-base balance	0.971	0.029
Chapter II Neoplasms	0.964	0.036
E66 Obesity	0.962	0.038
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis	0.962	0.038
Chapter V Mental and behavioural disorders	0.958	0.042
Chapter XV Pregnancy, childbirth and the puerperium	0.953	0.047
R94 Abnormal results of function studies	0.948	0.052
I30-I52 Other forms of heart disease	0.943	0.057
R94.5 Abnormal results of liver function studies	0.939	0.061
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites	0.937	0.063
E87.2 Acidosis	0.933	0.067
R22 Localised swelling, mass and lump of skin and subcutaneous tissue	0.931	0.069
I20.0 Unstable angina	0.931	0.069
I20.9 Angina pectoris, unspecified	0.930	0.070
I70-I79 Diseases of arteries, arterioles and capillaries	0.922	0.078
O60-O75 Complications of labour and delivery	0.919	0.081
E66.9 Obesity, unspecified	0.912	0.088
C78 Secondary malignant neoplasm of respiratory and digestive organs	0.909	0.091
E66.8 Other obesity	0.907	0.093
Chapter XIV Diseases of the genitourinary system	0.902	0.098
N17-N19 Renal failure	0.895	0.105
I50 Heart failure	0.894	0.106
Chapter XX External causes of morbidity and mortality	0.893	0.107
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour	0.886	0.114
F30-F39 Mood [affective] disorders	0.885	0.115
N17 Acute renal failure	0.880	0.120
C43-C44 Melanoma and other malignant neoplasms of skin	0.877	0.123
I25.8 Other forms of chronic ischaemic heart disease	0.874	0.126
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.868	0.132
R00-R09 Symptoms and signs involving the circulatory and respiratory systems	0.868	0.132
R22.9 Localised swelling, mass and lump, unspecified	0.866	0.134
O70 Perineal laceration during delivery	0.864	0.136
N17.9 Acute renal failure, unspecified	0.863	0.137
M65-M68 Disorders of synovium and tendon	0.861	0.139
M80-M85 Disorders of bone density and structure	0.860	0.139
M10 Gout	0.854	0.146
F40-F48 Neurotic, stress-related and somatoform disorders	0.853	0.147
E87.1 Hypo-osmolality and hyponatraemia	0.852	0.148
I50.1 Left ventricular failure	0.852	0.148
E87.6 Hypokalaemia	0.849	0.151
Chapter VI Diseases of the nervous system	0.846	0.154
C78.7 Secondary malignant neoplasm of liver	0.842	0.158
F32 Depressive episode	0.838	0.161
I22 Subsequent myocardial infarction	0.837	0.163
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems	0.837	0.163
R23 Other skin changes	0.837	0.163
I05-I09 Chronic rheumatic heart diseases	0.835	0.165
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx	0.834	0.166
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.832	0.168
I78 Diseases of capillaries	0.828	0.172
Chapter I Certain infectious and parasitic diseases	0.828	0.172
I25.3 Aneurysm of heart	0.826	0.174
C44 Other malignant neoplasms of skin	0.822	0.178
C78.6 Secondary malignant neoplasm of retroperitoneum and peritoneum	0.819	0.181
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs	0.818	0.182
N18 Chronic renal failure	0.817	0.183
N10-N16 Renal tubulo-interstitial diseases	0.816	0.184
I51 Complications and ill-defined descriptions of heart disease	0.815	0.185
M20-M25 Other joint disorders	0.804	0.196
R06 Abnormalities of breathing	0.801	0.199
I71 Aortic aneurysm and dissection	0.799	0.200
M86-M90 Other osteopathies	0.798	0.202
M06.4 Inflammatory polyarthropathy	0.796	0.204
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium	0.795	0.205
I38 Endocarditis, valve unspecified	0.784	0.216
R80-R82 Abnormal findings on examination of urine, without diagnosis	0.782	0.218
C79 Secondary malignant neoplasm of other sites	0.777	0.223
I50.0 Congestive heart failure	0.774	0.226
R01 Cardiac murmurs and other cardiac sounds	0.773	0.227
F32.9 Depressive episode, unspecified	0.771	0.229
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.771	0.229
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.771	0.229
O70.0 First degree perineal laceration during delivery	0.769	0.231
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified	0.764	0.236
I78.1 Naevus, nonneoplastic	0.760	0.240
I77 Other disorders of arteries and arterioles	0.759	0.241
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.758	0.242
R07 Pain in throat and chest	0.756	0.244
D37-D48 Neoplasms of uncertain or unknown behaviour	0.756	0.244
M05 Seropositive rheumatoid arthritis	0.754	0.245
O75 Other complications of labour and delivery, not elsewhere classified	0.754	0.246
F41 Other anxiety disorders	0.751	0.249
M10.9 Gout, unspecified	0.751	0.249
M06.0 Seronegative rheumatoid arthritis	0.750	0.250
O36 Maternal care for other known or suspected foetal problems	0.749	0.251
O70.1 Second degree perineal laceration during delivery	0.747	0.253
M91-M94 Chondropathies	0.746	0.254
M65 Synovitis and tenosynovitis	0.746	0.254
R22.3 Localised swelling, mass and lump, upper limb	0.742	0.257
Chapter XXII Codes for special purposes	0.741	0.259
C78.8 Secondary malignant neoplasm of other and unspecified digestive organs	0.741	0.259
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system	0.741	0.259
E87.7 Fluid overload	0.740	0.260
N12 Tubulo-interstitial nephritis, not specified as acute or chronic	0.735	0.265
C45-C49 Malignant neoplasms of mesothelial and soft tissue	0.734	0.266
F99-F99 Unspecified mental disorder	0.733	0.267
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.732	0.268
O64 Obstructed labour due to malposition and malpresentation of foetus	0.732	0.268
E78 Disorders of lipoprotein metabolism and other lipidaemias	0.729	0.271
E87.5 Hyperkalaemia	0.728	0.272
M07 Psoriatic and enteropathic arthropathies	0.728	0.272
C44.0 Skin of lip	0.728	0.272
I35 Nonrheumatic aortic valve disorders	0.727	0.273
D00-D09 In situ neoplasms	0.727	0.273
M81 Osteoporosis without pathological fracture	0.726	0.274
R06.5 Mouth breathing	0.726	0.274
C73-C75 Malignant neoplasms of thyroid and other endocrine glands	0.726	0.274
R06.8 Other and unspecified abnormalities of breathing	0.725	0.275
C44.3 Skin of other and unspecified parts of face	0.724	0.276
F60-F69 Disorders of adult personality and behaviour	0.723	0.276
R40 Somnolence, stupor and coma	0.723	0.277
E87.0 Hyperosmolality and hypernatraemia	0.722	0.278
I22.9 Subsequent myocardial infarction of unspecified site	0.722	0.278
N17.0 Acute renal failure with tubular necrosis	0.721	0.279
R50-R69 General symptoms and signs	0.721	0.279
E00-E07 Disorders of thyroid gland	0.719	0.281
C44.4 Skin of scalp and neck	0.718	0.282
M40-M43 Deforming dorsopathies	0.718	0.282
Chapter XVI Certain conditions originating in the perinatal period	0.717	0.283
I00-I02 Acute rheumatic fever	0.717	0.283
R95-R99 Ill-defined and unknown causes of mortality	0.716	0.284
M60-M63 Disorders of muscles	0.716	0.284
M00-M03 Infectious arthropathies	0.716	0.284
I34 Nonrheumatic mitral valve disorders	0.716	0.284
I23 Certain current complications following acute myocardial infarction	0.716	0.284
M14 Arthropathies in other diseases classified elsewhere	0.716	0.284
M12 Other specific arthropathies	0.716	0.284
M11 Other crystal arthropathies	0.716	0.284
M09 Juvenile arthritis in diseases classified elsewhere	0.716	0.284
M08 Juvenile arthritis	0.716	0.284
M06.8 Other specified rheumatoid arthritis	0.715	0.285
M06.3 Rheumatoid nodule	0.715	0.285
M06.2 Rheumatoid bursitis	0.715	0.285
M06.1 Adult-onset Still's disease	0.715	0.285
M06.98 Rheumatoid arthritis, unspecified (Other)	0.715	0.285
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)	0.715	0.285
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.715	0.285
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.715	0.285
M06.94 Rheumatoid arthritis, unspecified (Hand)	0.715	0.285
M06.93 Rheumatoid arthritis, unspecified (Forearm)	0.715	0.285
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.715	0.285
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.715	0.285
E40-E46 Malnutrition	0.715	0.285
F43 Reaction to severe stress, and adjustment disorders	0.714	0.285
C34 Malignant neoplasm of bronchus and lung	0.714	0.286
X60-X84 Intentional self-harm	0.712	0.288
I25.6 Silent myocardial ischaemia	0.711	0.289
I25.5 Ischaemic cardiomyopathy	0.711	0.289
I25.4 Coronary artery aneurysm	0.711	0.289
I25.0 Atherosclerotic cardiovascular disease, so described	0.711	0.289
O61 Failed induction of labour	0.710	0.290
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.709	0.291
I51.7 Cardiomegaly	0.706	0.293
N00-N08 Glomerular diseases	0.706	0.294
W20-W49 Exposure to inanimate mechanical forces	0.706	0.294
E80 Disorders of porphyrin and bilirubin metabolism	0.705	0.295
R01.1 Cardiac murmur, unspecified	0.705	0.295
R42 Dizziness and giddiness	0.702	0.298
R20 Disturbances of skin sensation	0.702	0.298
E85 Amyloidosis	0.701	0.298
E84 Cystic fibrosis	0.701	0.298
E79 Disorders of purine and pyrimidine metabolism	0.701	0.298
E77 Disorders of glycoprotein metabolism	0.701	0.298
E76 Disorders of glycosaminoglycan metabolism	0.701	0.298
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.701	0.298
E74 Other disorders of carbohydrate metabolism	0.701	0.298
E73 Lactose intolerance	0.701	0.298
E72 Other disorders of amino-acid metabolism	0.701	0.298
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.701	0.298
E70 Disorders of aromatic amino-acid metabolism	0.701	0.298
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.701	0.298
B95-B98 Bacterial, viral and other infectious agents	0.701	0.299
E67 Other hyperalimentation	0.700	0.300
E68 Sequelae of hyperalimentation	0.700	0.300
E65 Localised adiposity	0.700	0.300
C80 Malignant neoplasm without specification of site	0.697	0.303
I20.1 Angina pectoris with documented spasm	0.697	0.303
C51-C58 Malignant neoplasms of female genital organs	0.697	0.303
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified	0.696	0.303
E87.4 Mixed disorder of acid-base balance	0.696	0.303
E87.3 Alkalosis	0.696	0.303
I71.4 Abdominal aortic aneurysm, without mention of rupture	0.696	0.304
C78.2 Secondary malignant neoplasm of pleura	0.695	0.305
X50-X57 Overexertion, travel and privation	0.694	0.306
R90 Abnormal findings on diagnostic imaging of central nervous system	0.694	0.306
F32.2 Severe depressive episode without psychotic symptoms	0.694	0.306
B35-B49 Mycoses	0.693	0.307
R22.2 Localised swelling, mass and lump, trunk	0.692	0.308
I49 Other cardiac arrhythmias	0.692	0.308
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis	0.692	0.308
C97-C97 Malignant neoplasms of independent (primary) multiple sites	0.691	0.308
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system	0.691	0.308
C40-C41 Malignant neoplasms of bone and articular cartilage	0.691	0.308
R23.1 Pallor	0.691	0.309
C79.7 Secondary malignant neoplasm of adrenal gland	0.691	0.309
N18.4 Chronic kidney disease, stage 4	0.690	0.310
E66.2 Extreme obesity with alveolar hypoventilation	0.690	0.310
E66.1 Drug-induced obesity	0.690	0.310
E66.0 Obesity due to excess calories	0.690	0.310
I42 Cardiomyopathy	0.690	0.310
R92 Abnormal findings on diagnostic imaging of breast	0.689	0.311
R44 Other symptoms and signs involving general sensations and perceptions	0.689	0.311
I87 Other disorders of veins	0.689	0.311
G20-G26 Extrapyramidal and movement disorders	0.688	0.312
C01 Malignant neoplasm of base of tongue	0.687	0.313
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence	0.687	0.313
F80-F89 Disorders of psychological development	0.687	0.313
F70-F79 Mental retardation	0.687	0.313
R45 Symptoms and signs involving emotional state	0.686	0.314
C09 Malignant neoplasm of tonsil	0.685	0.315
M65.9 Synovitis and tenosynovitis, unspecified	0.684	0.316
I08 Multiple valve diseases	0.683	0.317
O85-O92 Complications predominantly related to the puerperium	0.683	0.317
E88 Other metabolic disorders	0.683	0.317
N18.9 Chronic renal failure, unspecified	0.683	0.317
O68 Labour and delivery complicated by foetal stress [distress]	0.681	0.319
M80 Osteoporosis with pathological fracture	0.680	0.320
R94.8 Abnormal results of function studies of other organs and systems	0.679	0.320
R94.7 Abnormal results of other endocrine function studies	0.679	0.320
R94.6 Abnormal results of thyroid function studies	0.679	0.320
R94.4 Abnormal results of kidney function studies	0.679	0.320
R94.2 Abnormal results of pulmonary function studies	0.679	0.320
R94.1 Abnormal results of function studies of peripheral nervous system and special senses	0.679	0.320
R94.0 Abnormal results of function studies of central nervous system	0.679	0.320
R03 Abnormal blood-pressure reading, without diagnosis	0.679	0.321
F41.0 Panic disorder [episodic paroxysmal anxiety]	0.678	0.322
F20-F29 Schizophrenia, schizotypal and delusional disorders	0.677	0.323
I52 Other heart disorders in diseases classified elsewhere	0.676	0.324
I48 Atrial fibrillation and flutter	0.676	0.324
I43 Cardiomyopathy in diseases classified elsewhere	0.676	0.324
I41 Myocarditis in diseases classified elsewhere	0.676	0.324
I40 Acute myocarditis	0.676	0.324
I39 Endocarditis and heart valve disorders in diseases classified elsewhere	0.676	0.324
I37 Pulmonary valve disorders	0.676	0.324
I36 Nonrheumatic tricuspid valve disorders	0.676	0.324
I32 Pericarditis in diseases classified elsewhere	0.676	0.324
I30 Acute pericarditis	0.676	0.324
O47 False labour	0.675	0.325
O73 Retained placenta and membranes, without haemorrhage	0.675	0.325
I95-I99 Other and unspecified disorders of the circulatory system	0.675	0.325
I51.9 Heart disease, unspecified	0.674	0.326
V10-V19 Pedal cyclist injured in transport accident	0.673	0.327
I33 Acute and subacute endocarditis	0.673	0.327
C76 Malignant neoplasm of other and ill-defined sites	0.672	0.328
V80-V89 Other land transport accidents	0.671	0.328
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors	0.671	0.329
R09 Other symptoms and signs involving the circulatory and respiratory systems	0.671	0.329
R22.7 Localised swelling, mass and lump, multiple sites	0.668	0.332
R22.1 Localised swelling, mass and lump, neck	0.668	0.332
R22.0 Localised swelling, mass and lump, head	0.668	0.332
O63 Long labour	0.667	0.333
I47 Paroxysmal tachycardia	0.666	0.334
C44.1 Skin of eyelid, including canthus	0.665	0.335
F10-F19 Mental and behavioural disorders due to psychoactive substance use	0.665	0.335
X40-X49 Accidental poisoning by and exposure to noxious substances	0.663	0.337
E50-E64 Other nutritional deficiencies	0.663	0.337
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.661	0.339
I72 Other aneurysm	0.661	0.339
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue	0.659	0.341
O74 Complications of anaesthesia during labour and delivery	0.659	0.341
O71 Other obstetric trauma	0.659	0.341
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified	0.659	0.341
O66 Other obstructed labour	0.659	0.341
O65 Obstructed labour due to maternal pelvic abnormality	0.659	0.341
O62 Abnormalities of forces of labour	0.659	0.341
O60 Preterm delivery	0.659	0.341
I77.6 Arteritis, unspecified	0.658	0.342
N70-N77 Inflammatory diseases of female pelvic organs	0.657	0.343
R07.3 Other chest pain	0.657	0.343
T36-T50 Poisoning by drugs, medicaments and biological substances	0.656	0.344
Y60-Y69 Misadventures to patients during surgical and medical care	0.655	0.345
G50-G59 Nerve, nerve root and plexus disorders	0.655	0.345
R23.3 Spontaneous ecchymoses	0.654	0.346
N60-N64 Disorders of breast	0.654	0.346
G90-G99 Other disorders of the nervous system	0.653	0.347
M10.99 Gout, unspecified (Site unspecified)	0.653	0.347
M67 Other disorders of synovium and tendon	0.653	0.347
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.652	0.347
M06.49 Inflammatory polyarthropathy (Site unspecified)	0.652	0.348
O70.2 Third degree perineal laceration during delivery	0.651	0.348
C78.5 Secondary malignant neoplasm of large intestine and rectum	0.651	0.348
C78.4 Secondary malignant neoplasm of small intestine	0.651	0.348
C78.3 Secondary malignant neoplasm of other and unspecified respiratory organs	0.651	0.348
C78.1 Secondary malignant neoplasm of mediastinum	0.651	0.348
M25 Other joint disorders, not elsewhere classified	0.651	0.349
V20-V29 Motorcycle rider injured in transport accident	0.651	0.349
Q60-Q64 Congenital malformations of the urinary system	0.648	0.352
I10-I15 Hypertensive diseases	0.647	0.353
F32.1 Moderate depressive episode	0.647	0.353
O36.8 Maternal care for other specified foetal problems	0.645	0.355
R22.4 Localised swelling, mass and lump, lower limb	0.644	0.356
I24 Other acute ischaemic heart diseases	0.644	0.356
O32 Maternal care for known or suspected malpresentation of foetus	0.644	0.356
I70 Atherosclerosis	0.643	0.357
G10-G14 Systemic atrophies primarily affecting the central nervous system	0.642	0.358
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.642	0.358
R94.3 Abnormal results of cardiovascular function studies	0.641	0.359
N99-N99 Other disorders of the genitourinary system	0.641	0.359
Chapter XII Diseases of the skin and subcutaneous tissue	0.640	0.360
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use	0.640	0.360
Y35-Y36 Legal intervention and operations of war	0.640	0.360
Y10-Y34 Event of undetermined intent	0.640	0.360
Y00-Y09 Assault	0.640	0.360
X85-X99 Assault	0.640	0.360
X58-X59 Accidental exposure to other and unspecified factors	0.640	0.360
X30-X39 Exposure to forces of nature	0.640	0.360
X20-X29 Contact with venomous animals and plants	0.640	0.360
X10-X19 Contact with heat and hot substances	0.640	0.360
X00-X09 Exposure to smoke, fire and flames	0.640	0.360
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure	0.640	0.360
W75-W84 Other accidental threats to breathing	0.640	0.360
W65-W74 Accidental drowning and submersion	0.640	0.360
W50-W64 Exposure to animate mechanical forces	0.640	0.360
V98-V99 Other and unspecified transport accidents	0.640	0.360
V95-V97 Air and space transport accidents	0.640	0.360
V90-V94 Water transport accidents	0.640	0.360
V70-V79 Bus occupant injured in transport accident	0.640	0.360
V60-V69 Occupant of heavy transport vehicle injured in transport accident	0.640	0.360
V50-V59 Occupant of pick-up truck or van injured in transport accident	0.640	0.360
V40-V49 Car occupant injured in transport accident	0.640	0.360
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident	0.640	0.360
V01-V09 Pedestrian injured in transport accident	0.640	0.360
O20-O29 Other maternal disorders predominantly related to pregnancy	0.639	0.361
N18.0 End-stage renal disease	0.638	0.362
O14 Gestational [pregnancy-induced] hypertension with significant proteinuria	0.638	0.362
Y52 Agents primarily affecting the cardiovascular system	0.638	0.362
G62 Other polyneuropathies	0.637	0.363
M22 Disorders of patella	0.637	0.363
O36.0 Maternal care for rhesus isoimmunisation	0.637	0.363
M89 Other disorders of bone	0.637	0.363
N25-N29 Other disorders of kidney and ureter	0.636	0.364
A30-A49 Other bacterial diseases	0.636	0.364
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.636	0.364
O13 Gestational [pregnancy-induced] hypertension without significant proteinuria	0.636	0.364
C34.9 Bronchus or lung, unspecified	0.636	0.364
E10-E14 Diabetes mellitus	0.636	0.364
I45 Other conduction disorders	0.635	0.364
R46 Symptoms and signs involving appearance and behaviour	0.635	0.365
R43 Disturbances of smell and taste	0.635	0.365
R47-R49 Symptoms and signs involving speech and voice	0.634	0.365
F38 Other mood [affective] disorders	0.634	0.366
F34 Persistent mood [affective] disorders	0.634	0.366
F30 Manic episode	0.634	0.366
F39 Unspecified mood [affective] disorder	0.634	0.366
R06.1 Stridor	0.634	0.366
C15-C26 Malignant neoplasms of digestive organs	0.632	0.368
M31 Other necrotising vasculopathies	0.631	0.369
N17.8 Other acute renal failure	0.631	0.369
N17.2 Acute renal failure with medullary necrosis	0.631	0.369
N17.1 Acute renal failure with acute cortical necrosis	0.631	0.369
M81.9 Osteoporosis, unspecified	0.630	0.370
Q20-Q28 Congenital malformations of the circulatory system	0.630	0.370
I60-I69 Cerebrovascular diseases	0.629	0.371
I07 Rheumatic tricuspid valve diseases	0.628	0.372
M24 Other specific joint derangements	0.627	0.373
C44.6 Skin of upper limb, including shoulder	0.627	0.373
R80 Isolated proteinuria	0.626	0.374
O30 Multiple gestation	0.626	0.374
E20-E35 Disorders of other endocrine glands	0.625	0.375
M21 Other acquired deformities of limbs	0.625	0.375
M65.96 Synovitis and tenosynovitis, unspecified (Lower leg)	0.625	0.375
I05 Rheumatic mitral valve diseases	0.624	0.375
R91 Abnormal findings on diagnostic imaging of lung	0.624	0.376
F00-F09 Organic, including symptomatic, mental disorders	0.623	0.377
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems	0.622	0.378
I80 Phlebitis and thrombophlebitis	0.622	0.378
Y45 Analgesics, antipyretics and anti-inflammatory drugs	0.621	0.378
R10-R19 Symptoms and signs involving the digestive system and abdomen	0.620	0.380
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.619	0.381
O70.9 Perineal laceration during delivery, unspecified	0.619	0.381
O70.3 Fourth degree perineal laceration during delivery	0.619	0.381
N10 Acute tubulo-interstitial nephritis	0.619	0.381
W00-W19 Falls	0.619	0.381
B00-B09 Viral infections characterized by skin and mucous membrane lesions	0.619	0.381
F33 Recurrent depressive disorder	0.618	0.382
M68 Disorders of synovium and tendon in diseases classified elsewhere	0.617	0.382
M66 Spontaneous rupture of synovium and tendon	0.617	0.382
M85 Other disorders of bone density and structure	0.617	0.383
M84 Disorders of continuity of bone	0.617	0.383
M83 Adult osteomalacia	0.617	0.383
M82 Osteoporosis in diseases classified elsewhere	0.617	0.383
F31 Bipolar affective disorder	0.617	0.383
I25.1 Atherosclerotic heart disease	0.617	0.383
R41 Other symptoms and signs involving cognitive functions and awareness	0.617	0.383
O69 Labour and delivery complicated by umbilical cord complications	0.616	0.384
N18.5 Chronic kidney disease, stage 5	0.616	0.384
F43.2 Adjustment disorders	0.615	0.385
N30-N39 Other diseases of urinary system	0.615	0.385
O48 Prolonged pregnancy	0.614	0.386
I74 Arterial embolism and thrombosis	0.613	0.387
R11 Nausea and vomiting	0.613	0.387
I71.2 Thoracic aortic aneurysm, without mention of rupture	0.613	0.387
M10.4 Other secondary gout	0.612	0.388
M10.3 Gout due to impairment of renal function	0.612	0.388
M10.2 Drug-induced gout	0.612	0.388
M10.1 Lead-induced gout	0.612	0.388
M10.0 Idiopathic gout	0.612	0.388
N13 Obstructive and reflux uropathy	0.612	0.388
F48 Other neurotic disorders	0.611	0.388
F44 Dissociative [conversion] disorders	0.611	0.388
F42 Obsessive-compulsive disorder	0.611	0.388
F41.9 Anxiety disorder, unspecified	0.611	0.389
I89 Other non-infective disorders of lymphatic vessels and lymph nodes	0.609	0.391
C77 Secondary and unspecified malignant neoplasm of lymph nodes	0.608	0.392
E83 Disorders of mineral metabolism	0.608	0.392
G70-G73 Diseases of myoneural junction and muscle	0.607	0.393
G00-G09 Inflammatory diseases of the central nervous system	0.607	0.393
R40.0 Somnolence	0.605	0.395
I77.9 Disorder of arteries and arterioles, unspecified	0.605	0.395
R20.8 Other and unspecified disturbances of skin sensation	0.603	0.397
S70-S79 Injuries to the hip and thigh	0.603	0.397
O75.7 Vaginal delivery following previous Caesarean section	0.602	0.398
I08.3 Combined disorders of mitral, aortic and tricuspid valves	0.602	0.398
Y40 Systemic antibiotics	0.602	0.398
R57 Shock, not elsewhere classified	0.601	0.398
F32.8 Other depressive episodes	0.601	0.399
F32.3 Severe depressive episode with psychotic symptoms	0.601	0.399
F32.0 Mild depressive episode	0.601	0.399
I87.2 Venous insufficiency (chronic) (peripheral)	0.601	0.399
I22.8 Subsequent myocardial infarction of other sites	0.600	0.400
I22.1 Subsequent myocardial infarction of inferior wall	0.600	0.400
I22.0 Subsequent myocardial infarction of anterior wall	0.600	0.400
O45 Premature separation of placenta [abruptio placentae]	0.600	0.400
O44 Placenta praevia	0.600	0.400
O43 Placental disorders	0.600	0.400
O41 Other disorders of amniotic fluid and membranes	0.600	0.400
O35 Maternal care for known or suspected foetal abnormality and damage	0.600	0.400
O33 Maternal care for known or suspected disproportion	0.600	0.400
O31 Complications specific to multiple gestation	0.600	0.400
O40 Polyhydramnios	0.600	0.400
R23.4 Changes in skin texture	0.600	0.400
R23.2 Flushing	0.600	0.400
R23.0 Cyanosis	0.600	0.400
I49.5 Sick sinus syndrome	0.600	0.400
R51 Headache	0.599	0.401
G35-G37 Demyelinating diseases of the central nervous system	0.599	0.401
C43 Malignant melanoma of skin	0.599	0.401
I09 Other rheumatic heart diseases	0.599	0.401
I06 Rheumatic aortic valve diseases	0.599	0.401
C79.9 Secondary malignant neoplasm, unspecified site	0.598	0.401
C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx	0.598	0.402
C13 Malignant neoplasm of hypopharynx	0.598	0.402
C11 Malignant neoplasm of nasopharynx	0.598	0.402
C10 Malignant neoplasm of oropharynx	0.598	0.402
C08 Malignant neoplasm of other and unspecified major salivary glands	0.598	0.402
C06 Malignant neoplasm of other and unspecified parts of mouth	0.598	0.402
C05 Malignant neoplasm of palate	0.598	0.402
C04 Malignant neoplasm of floor of mouth	0.598	0.402
C03 Malignant neoplasm of gum	0.598	0.402
C02 Malignant neoplasm of other and unspecified parts of tongue	0.598	0.402
C00 Malignant neoplasm of lip	0.598	0.402
C12 Malignant neoplasm of pyriform sinus	0.598	0.402
C07 Malignant neoplasm of parotid gland	0.598	0.402
B96 Other bacterial agents as the cause of diseases classified to other chapters	0.598	0.402
O64.0 Obstructed labour due to incomplete rotation of foetal head	0.598	0.402
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere	0.598	0.402
B15-B19 Viral hepatitis	0.597	0.403
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.596	0.403
Q80-Q89 Other congenital malformations	0.596	0.403
Q50-Q56 Congenital malformations of genital organs	0.596	0.403
Q38-Q45 Other congenital malformations of the digestive system	0.596	0.403
Q35-Q37 Cleft lip and cleft palate	0.596	0.403
Q30-Q34 Congenital malformations of the respiratory system	0.596	0.403
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.596	0.403
Q00-Q07 Congenital malformations of the nervous system	0.596	0.403
R23.8 Other and unspecified skin changes	0.595	0.405
G30-G32 Other degenerative diseases of the nervous system	0.595	0.405
E78.9 Disorder of lipoprotein metabolism, unspecified	0.595	0.405
I78.9 Disease of capillaries, unspecified	0.594	0.406
I78.8 Other diseases of capillaries	0.594	0.406
I78.0 Hereditary haemorrhagic telangiectasia	0.594	0.406
B99-B99 Other infectious diseases	0.593	0.406
B90-B94 Sequelae of infectious and parasitic diseases	0.593	0.406
B85-B89 Pediculosis, acariasis and other infestations	0.593	0.406
B65-B83 Helminthiases	0.593	0.406
B50-B64 Protozoal diseases	0.593	0.406
B20-B24 Human immunodeficiency virus [HIV] disease	0.593	0.406
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers	0.593	0.406
A80-A89 Viral infections of the central nervous system	0.593	0.406
A75-A79 Rickettsioses	0.593	0.406
A70-A74 Other diseases caused by chlamydiae	0.593	0.406
A65-A69 Other spirochaetal diseases	0.593	0.406
A50-A64 Infections with a predominantly sexual mode of transmission	0.593	0.406

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations