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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs114956680
log Bayes Factor = 15.956
Chromosome 4   position 55,817,709  (GRCh37) Explore rs114956680 on Ensembl!
Variant rs114956680 is part of Cluster X0161

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter VII Diseases of the eye and adnexa
0.999 0.001 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.999 0.001 0.000
M20-M25 Other joint disorders
0.999 0.001 0.000
M23 Internal derangement of knee
0.998 0.002 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.997 0.003 0.000
M23.2 Derangement of meniscus due to old tear or injury
0.996 0.004 0.000
Chapter XI Diseases of the digestive system
0.995 0.005 0.000
M15-M19 Arthrosis
0.994 0.006 0.000
H30-H36 Disorders of choroid and retina
0.988 0.012 0.000
M17 Gonarthrosis [arthrosis of knee]
0.984 0.016 0.000
M23.22 Derangement of meniscus due to old tear or injury (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.981 0.019 0.000
H35 Other retinal disorders
0.981 0.019 0.000
Chapter V Mental and behavioural disorders
0.980 0.020 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.977 0.023 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.975 0.025 0.000
K70-K77 Diseases of liver
0.962 0.038 0.000
H35.3 Degeneration of macula and posterior pole
0.960 0.040 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.958 0.042 0.000
Chapter VI Diseases of the nervous system
0.957 0.043 0.000
M23.23 Derangement of meniscus due to old tear or injury (Medial collateral ligament or Other and unspecified medial meniscus)
0.956 0.044 0.000
Chapter XX External causes of morbidity and mortality
0.956 0.044 0.000
M17.9 Gonarthrosis, unspecified
0.955 0.045 0.000
Chapter I Certain infectious and parasitic diseases
0.952 0.048 0.000
S80-S89 Injuries to the knee and lower leg
0.951 0.049 0.000
M25 Other joint disorders, not elsewhere classified
0.946 0.054 0.000
K20-K31 Diseases of oesophagus, stomach and duodenum
0.941 0.059 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.938 0.062 0.000
T81 Complications of procedures, not elsewhere classified
0.937 0.063 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.932 0.068 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.930 0.070 0.000
M70-M79 Other soft tissue disorders
0.925 0.075 0.000
T81.8 Other complications of procedures, not elsewhere classified
0.924 0.076 0.000
M45-M49 Spondylopathies
0.923 0.077 0.000
R42 Dizziness and giddiness
0.921 0.079 0.000
M19 Other arthrosis
0.917 0.083 0.000
K90-K93 Other diseases of the digestive system
0.915 0.085 0.000
H53-H54 Visual disturbances and blindness
0.913 0.087 0.000
K30 Dyspepsia
0.911 0.089 0.000
F41 Other anxiety disorders
0.910 0.090 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.908 0.092 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.907 0.093 0.000
M05-M14 Inflammatory polyarthropathies
0.906 0.094 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.905 0.095 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.903 0.097 0.000
M25.7 Osteophyte
0.901 0.099 0.000
D60-D64 Aplastic and other anaemias
0.899 0.101 0.000
B95-B98 Bacterial, viral and other infectious agents
0.897 0.103 0.000
M75 Shoulder lesions
0.895 0.105 0.000
R41 Other symptoms and signs involving cognitive functions and awareness
0.886 0.114 0.000
H40-H42 Glaucoma
0.884 0.116 0.000
K90 Intestinal malabsorption
0.881 0.118 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.880 0.120 0.000
D64 Other anaemias
0.879 0.121 0.000
K76 Other diseases of liver
0.874 0.126 0.000
H43-H45 Disorders of vitreous body and globe
0.874 0.126 0.000
K35-K38 Diseases of appendix
0.873 0.127 0.000
G40-G47 Episodic and paroxysmal disorders
0.870 0.130 0.000
K29 Gastritis and duodenitis
0.867 0.133 0.000
D64.9 Anaemia, unspecified
0.865 0.135 0.000
R91 Abnormal findings on diagnostic imaging of lung
0.863 0.137 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.859 0.141 0.000
K90.0 Coeliac disease
0.858 0.142 0.000
M13 Other arthritis
0.856 0.144 0.000
M17.0 Primary gonarthrosis, bilateral
0.855 0.145 0.000
Chapter II Neoplasms
0.853 0.147 0.000
M23.21 Derangement of meniscus due to old tear or injury (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.846 0.154 0.000
K00-K14 Diseases of oral cavity, salivary glands and jaws
0.844 0.156 0.000
M23.4 Loose body in knee
0.844 0.156 0.000
H55-H59 Other disorders of eye and adnexa
0.842 0.158 0.000
S20-S29 Injuries to the thorax
0.841 0.159 0.000
K65-K67 Diseases of peritoneum
0.839 0.161 0.000
H35.8 Other specified retinal disorders
0.839 0.161 0.000
Chapter IX Diseases of the circulatory system
0.838 0.162 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.836 0.164 0.000
M75.0 Adhesive capsulitis of shoulder
0.836 0.164 0.000
S82 Fracture of lower leg, including ankle
0.835 0.165 0.000
M17.1 Other primary gonarthrosis
0.834 0.166 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.832 0.168 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.832 0.168 0.000
M22 Disorders of patella
0.824 0.176 0.000
H53 Visual disturbances
0.824 0.176 0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee
0.823 0.177 0.000
M13.9 Arthritis, unspecified
0.821 0.179 0.000
M19.9 Arthrosis, unspecified
0.821 0.179 0.000
M25.76 Osteophyte (Lower leg)
0.819 0.181 0.000
K31 Other diseases of stomach and duodenum
0.818 0.182 0.000
K75 Other inflammatory liver diseases
0.817 0.183 0.000
F41.0 Panic disorder [episodic paroxysmal anxiety]
0.817 0.183 0.000
Y84 Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.816 0.184 0.000
T81.0 Haemorrhage and haematoma complicating a procedure, not elsewhere classified
0.815 0.185 0.000
K76.0 Fatty (change of) liver, not elsewhere classified
0.813 0.187 0.000
M47 Spondylosis
0.812 0.188 0.000
T85.8 Other complications of internal prosthetic devices, implants and grafts, not elsewhere classified
0.811 0.189 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.806 0.194 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.805 0.194 0.000
K29.6 Other gastritis
0.805 0.195 0.000
H35.6 Retinal haemorrhage
0.804 0.195 0.000
F41.9 Anxiety disorder, unspecified
0.803 0.197 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.803 0.197 0.000
M23.29 Derangement of meniscus due to old tear or injury (Unspecified ligament or Unspecified meniscus)
0.802 0.198 0.000
H40 Glaucoma
0.802 0.198 0.000
R41.0 Disorientation, unspecified
0.799 0.201 0.000
K74 Fibrosis and cirrhosis of liver
0.799 0.201 0.000
Y83 Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.799 0.201 0.000
K35 Acute appendicitis
0.799 0.201 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.798 0.202 0.000
S90-S99 Injuries to the ankle and foot
0.798 0.202 0.000
R47-R49 Symptoms and signs involving speech and voice
0.798 0.202 0.000
K25 Gastric ulcer
0.792 0.208 0.000
M18 Arthrosis of first carpometacarpal joint
0.785 0.215 0.000
R79 Other abnormal findings of blood chemistry
0.784 0.216 0.000
M48 Other spondylopathies
0.784 0.216 0.000
H43 Disorders of vitreous body
0.784 0.216 0.000
M23.8 Other internal derangements of knee
0.779 0.220 0.000
T85.4 Mechanical complication of breast prosthesis and implant
0.778 0.222 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.778 0.222 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.776 0.224 0.000
F41.2 Mixed anxiety and depressive disorder
0.775 0.225 0.000
D10-D36 Benign neoplasms
0.775 0.225 0.000
H35.0 Background retinopathy and retinal vascular changes
0.773 0.227 0.000
R20 Disturbances of skin sensation
0.773 0.227 0.000
R73 Elevated blood glucose level
0.770 0.230 0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters
0.768 0.232 0.000
O00-O08 Pregnancy with abortive outcome
0.767 0.232 0.000
A30-A49 Other bacterial diseases
0.767 0.233 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.767 0.233 0.000
M19.0 Primary arthrosis of other joints
0.766 0.234 0.000
M80-M85 Disorders of bone density and structure
0.766 0.234 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.765 0.235 0.000
M86-M90 Other osteopathies
0.764 0.235 0.000
X60-X84 Intentional self-harm
0.764 0.236 0.000
O42 Premature rupture of membranes
0.764 0.236 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.763 0.237 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.763 0.237 0.000
S50-S59 Injuries to the elbow and forearm
0.763 0.237 0.000
S89 Other and unspecified injuries of lower leg
0.762 0.237 0.000
G45 Transient cerebral ischaemic attacks and related syndromes
0.762 0.238 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.762 0.238 0.000
H40.9 Glaucoma, unspecified
0.761 0.239 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.759 0.241 0.000
M65-M68 Disorders of synovium and tendon
0.757 0.243 0.000
M75.3 Calcific tendinitis of shoulder
0.757 0.243 0.000
Y83.8 Other surgical procedures
0.757 0.243 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.756 0.243 0.000
M21 Other acquired deformities of limbs
0.754 0.246 0.000
S40-S49 Injuries to the shoulder and upper arm
0.753 0.247 0.000
H10-H13 Disorders of conjunctiva
0.752 0.248 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.751 0.249 0.000
M13.96 Arthritis, unspecified (Lower leg)
0.751 0.249 0.000
S82.6 Fracture of lateral malleolus
0.751 0.249 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.751 0.249 0.000
K72 Hepatic failure, not elsewhere classified
0.750 0.250 0.000
M13.99 Arthritis, unspecified (Site unspecified)
0.750 0.250 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.748 0.252 0.000
B15-B19 Viral hepatitis
0.745 0.255 0.000
F80-F89 Disorders of psychological development
0.745 0.255 0.000
B96 Other bacterial agents as the cause of diseases classified to other chapters
0.743 0.257 0.000
X20-X29 Contact with venomous animals and plants
0.742 0.258 0.000
O80-O84 Delivery
0.742 0.258 0.000
O85-O92 Complications predominantly related to the puerperium
0.741 0.259 0.000
M25.78 Osteophyte (Other)
0.740 0.260 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.740 0.260 0.000
H34 Retinal vascular occlusions
0.740 0.260 0.000
M23.3 Other meniscus derangements
0.739 0.261 0.000
K91 Postprocedural disorders of digestive system, not elsewhere classified
0.739 0.261 0.000
F06 Other mental disorders due to brain damage and dysfunction and to physical disease
0.738 0.261 0.000
O60-O75 Complications of labour and delivery
0.739 0.261 0.000
O36 Maternal care for other known or suspected foetal problems
0.738 0.262 0.000
R23 Other skin changes
0.737 0.263 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.737 0.263 0.000
I95 Hypotension
0.736 0.264 0.000
K65 Peritonitis
0.736 0.264 0.000
R45 Symptoms and signs involving emotional state
0.736 0.264 0.000
S81 Open wound of lower leg
0.734 0.266 0.000
M23.49 Loose body in knee-Unspec lig/men
0.733 0.267 0.000
W20-W49 Exposure to inanimate mechanical forces
0.733 0.267 0.000
H54 Blindness and low vision
0.733 0.267 0.000
H00 Hordeolum and chalazion
0.732 0.268 0.000
K29.8 Duodenitis
0.728 0.272 0.000
M77 Other enthesopathies
0.726 0.274 0.000
M75.2 Bicipital tendinitis
0.725 0.275 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.725 0.275 0.000
T66-T78 Other and unspecified effects of external causes
0.725 0.275 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.724 0.275 0.000
Chapter XXII Codes for special purposes
0.722 0.278 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.721 0.279 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.721 0.279 0.000
B97 Viral agents as the cause of diseases classified to other chapters
0.720 0.280 0.000
K11 Diseases of salivary glands
0.720 0.280 0.000
G62 Other polyneuropathies
0.719 0.280 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.719 0.281 0.000
K35.9 Acute appendicitis, unspecified
0.719 0.281 0.000
H53.1 Subjective visual disturbances
0.718 0.282 0.000
M91-M94 Chondropathies
0.717 0.283 0.000
M60-M63 Disorders of muscles
0.717 0.283 0.000
M00-M03 Infectious arthropathies
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
M25.77 Osteophyte (Ankle and foot)
0.717 0.283 0.000
T79-T79 Certain early complications of trauma
0.716 0.283 0.000
T33-T35 Frostbite
0.716 0.283 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.716 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.716 0.283 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.716 0.283 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.716 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.716 0.283 0.000
S10-S19 Injuries to the neck
0.716 0.283 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.716 0.284 0.000
M34 Systemic sclerosis
0.716 0.284 0.000
M33 Dermatopolymyositis
0.716 0.284 0.000
M32 Systemic lupus erythematosus
0.716 0.284 0.000
M30 Polyarteritis nodosa and related conditions
0.716 0.284 0.000
H36 Retinal disorders in diseases classified elsewhere
0.716 0.284 0.000
B98 Other specified infectious agents as the cause of diseases classified to other chapters
0.716 0.284 0.000
H55 Nystagmus and other irregular eye movements
0.716 0.284 0.000
M23.9 Internal derangement of knee, unspecified
0.715 0.284 0.000
M23.6 Other spontaneous disruption of ligament(s) of knee
0.715 0.284 0.000
M23.5 Chronic instability of knee
0.715 0.284 0.000
M23.1 Discoid meniscus (congenital)
0.715 0.284 0.000
M23.0 Cystic meniscus
0.715 0.284 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.715 0.285 0.000
G20-G26 Extrapyramidal and movement disorders
0.715 0.285 0.000
M23.27 Derangement of meniscus due to old tear or injury-Capsular
0.714 0.286 0.000
M23.25 Derangement of meniscus due to old tear or injury (Posterior horn of lateral meniscus)
0.714 0.286 0.000
M15 Polyarthrosis
0.713 0.287 0.000
R94 Abnormal results of function studies
0.711 0.288 0.000
D17 Benign lipomatous neoplasm
0.711 0.289 0.000
S83.2 Tear of meniscus, current
0.710 0.290 0.000
M47.9 Spondylosis, unspecified
0.710 0.290 0.000
K31.8 Other specified diseases of stomach and duodenum
0.709 0.291 0.000
H43.8 Other disorders of vitreous body
0.709 0.291 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.708 0.292 0.000
H31 Other disorders of choroid
0.708 0.292 0.000
H30 Chorioretinal inflammation
0.708 0.292 0.000
F03 Unspecified dementia
0.707 0.293 0.000
H00.1 Chalazion
0.706 0.294 0.000
M17.5 Other secondary gonarthrosis
0.706 0.294 0.000
M17.4 Other secondary gonarthrosis, bilateral
0.706 0.294 0.000
M17.3 Other posttraumatic gonarthrosis
0.706 0.294 0.000
M17.2 Posttraumatic gonarthrosis, bilateral
0.706 0.294 0.000
M40-M43 Deforming dorsopathies
0.705 0.294 0.000
B25-B34 Other viral diseases
0.705 0.295 0.000
H35.9 Retinal disorder, unspecified
0.703 0.297 0.000
H35.7 Separation of retinal layers
0.703 0.297 0.000
H35.5 Hereditary retinal dystrophy
0.703 0.297 0.000
H35.4 Peripheral retinal degeneration
0.703 0.297 0.000
H35.2 Other proliferative retinopathy
0.703 0.297 0.000
H35.1 Retinopathy of prematurity
0.703 0.297 0.000
F99-F99 Unspecified mental disorder
0.702 0.297 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.702 0.297 0.000
F70-F79 Mental retardation
0.702 0.297 0.000
F60-F69 Disorders of adult personality and behaviour
0.702 0.297 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.702 0.297 0.000
R21 Rash and other nonspecific skin eruption
0.702 0.298 0.000
M23.20 Derangement of meniscus due to old tear or injury (Multiple sites)
0.702 0.298 0.000
I95.9 Hypotension, unspecified
0.702 0.298 0.000
R90 Abnormal findings on diagnostic imaging of central nervous system
0.702 0.298 0.000
K31.9 Disease of stomach and duodenum, unspecified
0.701 0.299 0.000
T87 Complications peculiar to reattachment and amputation
0.700 0.300 0.000
T86 Failure and rejection of transplanted organs and tissues
0.700 0.300 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.700 0.300 0.000
R46 Symptoms and signs involving appearance and behaviour
0.699 0.301 0.000
R43 Disturbances of smell and taste
0.699 0.301 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.697 0.303 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.696 0.303 0.000
Y84.2 Radiological procedure and radiotherapy
0.695 0.305 0.000
I73 Other peripheral vascular diseases
0.695 0.305 0.000
S70-S79 Injuries to the hip and thigh
0.694 0.306 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.694 0.306 0.000
K04 Diseases of pulp and periapical tissues
0.693 0.307 0.000
F01 Vascular dementia
0.693 0.307 0.000
M75.4 Impingement syndrome of shoulder
0.693 0.307 0.000
M75.1 Rotator cuff syndrome
0.693 0.307 0.000
F45 Somatoform disorders
0.692 0.308 0.000
R41.3 Other amnesia
0.692 0.308 0.000
K02 Dental caries
0.692 0.308 0.000
O02 Other abnormal products of conception
0.692 0.308 0.000
M25.4 Effusion of joint
0.691 0.309 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.691 0.309 0.000
S82.60 Fracture of lateral malleolus (closed)
0.691 0.309 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.691 0.309 0.000
V20-V29 Motorcycle rider injured in transport accident
0.690 0.310 0.000
K77 Liver disorders in diseases classified elsewhere
0.690 0.310 0.000
K73 Chronic hepatitis, not elsewhere classified
0.690 0.310 0.000
K71 Toxic liver disease
0.690 0.310 0.000
S60-S69 Injuries to the wrist and hand
0.689 0.311 0.000
D62 Acute posthaemorrhagic anaemia
0.688 0.312 0.000
B95.7 Other staphylococcus as the cause of diseases classified to other chapters
0.688 0.312 0.000
W00-W19 Falls
0.688 0.312 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.688 0.312 0.000
G43 Migraine
0.687 0.313 0.000
R79.8 Other specified abnormal findings of blood chemistry
0.687 0.313 0.000
C64-C68 Malignant neoplasms of urinary tract
0.687 0.313 0.000
D23 Other benign neoplasms of skin
0.686 0.314 0.000
G70-G73 Diseases of myoneural junction and muscle
0.686 0.314 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.686 0.314 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.686 0.314 0.000
R93 Abnormal findings on diagnostic imaging of other body structures
0.686 0.314 0.000
K75.0 Abscess of liver
0.686 0.314 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.685 0.314 0.000
Y35-Y36 Legal intervention and operations of war
0.685 0.314 0.000
Y10-Y34 Event of undetermined intent
0.685 0.314 0.000
Y00-Y09 Assault
0.685 0.314 0.000
X85-X99 Assault
0.685 0.314 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.685 0.314 0.000
X50-X57 Overexertion, travel and privation
0.685 0.314 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.685 0.314 0.000
X30-X39 Exposure to forces of nature
0.685 0.314 0.000
X10-X19 Contact with heat and hot substances
0.685 0.314 0.000
X00-X09 Exposure to smoke, fire and flames
0.685 0.314 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.685 0.314 0.000
W75-W84 Other accidental threats to breathing
0.685 0.314 0.000
W65-W74 Accidental drowning and submersion
0.685 0.314 0.000
W50-W64 Exposure to animate mechanical forces
0.685 0.314 0.000
V98-V99 Other and unspecified transport accidents
0.685 0.314 0.000
V95-V97 Air and space transport accidents
0.685 0.314 0.000
V90-V94 Water transport accidents
0.685 0.314 0.000
V80-V89 Other land transport accidents
0.685 0.314 0.000
V70-V79 Bus occupant injured in transport accident
0.685 0.314 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.685 0.314 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.685 0.314 0.000
V40-V49 Car occupant injured in transport accident
0.685 0.314 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.685 0.314 0.000
V01-V09 Pedestrian injured in transport accident
0.685 0.314 0.000
M48.0 Spinal stenosis
0.684 0.316 0.000
M19.90 Arthrosis, unspecified (Multiple sites)
0.684 0.316 0.000
G30-G32 Other degenerative diseases of the nervous system
0.683 0.317 0.000
B99-B99 Other infectious diseases
0.682 0.318 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.682 0.318 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.682 0.318 0.000
B65-B83 Helminthiases
0.682 0.318 0.000
B50-B64 Protozoal diseases
0.682 0.318 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.682 0.318 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.682 0.318 0.000
A80-A89 Viral infections of the central nervous system
0.682 0.318 0.000
A75-A79 Rickettsioses
0.682 0.318 0.000
A70-A74 Other diseases caused by chlamydiae
0.682 0.318 0.000
A65-A69 Other spirochaetal diseases
0.682 0.318 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.682 0.318 0.000
A20-A28 Certain zoonotic bacterial diseases
0.682 0.318 0.000
A15-A19 Tuberculosis
0.682 0.318 0.000
R22 Localised swelling, mass and lump of skin and subcutaneous tissue
0.682 0.318 0.000
R20.8 Other and unspecified disturbances of skin sensation
0.682 0.318 0.000
S88 Traumatic amputation of lower leg
0.682 0.318 0.000
S87 Crushing injury of lower leg
0.682 0.318 0.000
S86 Injury of muscle and tendon at lower leg level
0.682 0.318 0.000
S85 Injury of blood vessels at lower leg level
0.682 0.318 0.000
S84 Injury of nerves at lower leg level
0.682 0.318 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.682 0.318 0.000
M31 Other necrotising vasculopathies
0.682 0.318 0.000
H53.9 Visual disturbance, unspecified
0.681 0.319 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.681 0.319 0.000
Q50-Q56 Congenital malformations of genital organs
0.681 0.319 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.681 0.319 0.000
M22.4 Chondromalacia patellae
0.680 0.320 0.000
K76.6 Portal hypertension
0.679 0.321 0.000
M10 Gout
0.679 0.321 0.000
G45.9 Transient cerebral ischaemic attack, unspecified
0.679 0.321 0.000
M25.9 Joint disorder, unspecified
0.678 0.321 0.000
M25.8 Other specified joint disorders
0.678 0.321 0.000
M25.3 Other instability of joint
0.678 0.321 0.000
M25.2 Flail joint
0.678 0.321 0.000
M25.1 Fistula of joint
0.678 0.321 0.000
M25.0 Haemarthrosis
0.678 0.321 0.000
M19.96 Arthrosis, unspecified-Lower leg
0.678 0.322 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.676 0.324 0.000
V10-V19 Pedal cyclist injured in transport accident
0.676 0.324 0.000
K27 Peptic ulcer, site unspecified
0.675 0.325 0.000
K28 Gastrojejunal ulcer
0.675 0.325 0.000
K23 Disorders of oesophagus in diseases classified elsewhere
0.675 0.325 0.000
M45 Ankylosing spondylitis
0.674 0.326 0.000
Y83.3 Surgical operation with formation of external stoma
0.674 0.326 0.000
M25.74 Osteophyte (Hand)
0.673 0.327 0.000
F48 Other neurotic disorders
0.672 0.327 0.000
F44 Dissociative [conversion] disorders
0.672 0.327 0.000
F42 Obsessive-compulsive disorder
0.672 0.327 0.000
T81.9 Unspecified complication of procedure
0.671 0.328 0.000
T81.7 Vascular complications following a procedure, not elsewhere classified
0.671 0.328 0.000
T81.6 Acute reaction to foreign substance accidentally left during a procedure
0.671 0.328 0.000
T81.5 Foreign body accidentally left in body cavity or operation wound following a procedure
0.671 0.328 0.000
T81.1 Shock during or resulting from a procedure, not elsewhere classified
0.671 0.328 0.000
M46 Other inflammatory spondylopathies
0.669 0.330 0.000
R92 Abnormal findings on diagnostic imaging of breast
0.668 0.332 0.000
D55-D59 Haemolytic anaemias
0.667 0.333 0.000
M24 Other specific joint derangements
0.666 0.333 0.000
F43 Reaction to severe stress, and adjustment disorders
0.664 0.336 0.000
M76 Enthesopathies of lower limb, excluding foot
0.663 0.337 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.663 0.337 0.000
M71 Other bursopathies
0.663 0.337 0.000
R73.9 Hyperglycaemia, unspecified
0.663 0.337 0.000
G90-G99 Other disorders of the nervous system
0.662 0.337 0.000
M49 Spondylopathies in diseases classified elsewhere
0.662 0.338 0.000
K70 Alcoholic liver disease
0.662 0.338 0.000
K35.8 Acute appendicitis, other and unspecified
0.661 0.339 0.000
K26 Duodenal ulcer
0.661 0.339 0.000
S22 Fracture of rib(s), sternum and thoracic spine
0.661 0.339 0.000
R76 Other abnormal immunological findings in serum
0.659 0.341 0.000
S82.3 Fracture of lower end of tibia
0.658 0.342 0.000
M18.9 Arthrosis of first carpometacarpal joint, unspecified
0.657 0.343 0.000
M19.8 Other specified arthrosis
0.657 0.343 0.000
M19.2 Other secondary arthrosis
0.657 0.343 0.000
M19.1 Posttraumatic arthrosis of other joints
0.657 0.343 0.000
K12 Stomatitis and related lesions
0.656 0.344 0.000
D00-D09 In situ neoplasms
0.656 0.344 0.000
O46 Antepartum haemorrhage, not elsewhere classified
0.656 0.344 0.000
K93 Disorders of other digestive organs in diseases classified elsewhere
0.656 0.344 0.000
S80 Superficial injury of lower leg
0.656 0.344 0.000
O42.0 Premature rupture of membranes, onset of labour within 24 hours
0.655 0.344 0.000
M19.92 Arthrosis, unspecified (Upper arm)
0.655 0.345 0.000
I05-I09 Chronic rheumatic heart diseases
0.654 0.346 0.000
H46 Optic neuritis
0.654 0.346 0.000
R50-R69 General symptoms and signs
0.654 0.346 0.000
S29 Other and unspecified injuries of thorax
0.654 0.346 0.000
K74.6 Other and unspecified cirrhosis of liver
0.653 0.347 0.000
G44 Other headache syndromes
0.653 0.347 0.000
F41.8 Other specified anxiety disorders
0.652 0.348 0.000
F41.3 Other mixed anxiety disorders
0.652 0.348 0.000
F41.1 Generalised anxiety disorder
0.652 0.348 0.000
S27 Injury of other and unspecified intrathoracic organs
0.652 0.348 0.000
R29 Other symptoms and signs involving the nervous and musculoskeletal systems
0.652 0.348 0.000
M25.75 Osteophyte (Pelvic region and thigh)
0.652 0.348 0.000
R27 Other lack of coordination
0.651 0.349 0.000
K29.5 Chronic gastritis, unspecified
0.651 0.349 0.000
R78 Findings of drugs and other substances, not normally found in blood
0.650 0.349 0.000
R77 Other abnormalities of plasma proteins
0.650 0.349 0.000
R74 Abnormal serum enzyme levels
0.650 0.349 0.000
R70 Elevated erythrocyte sedimentation rate and abnormality of plasma viscosity
0.650 0.349 0.000
R75 Laboratory evidence of human immunodeficiency virus [HIV]
0.650 0.349 0.000
R71 Abnormality of red blood cells
0.650 0.349 0.000
H40.5 Glaucoma secondary to other eye disorders
0.650 0.349 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.650 0.350 0.000
I72 Other aneurysm
0.650 0.350 0.000
M14 Arthropathies in other diseases classified elsewhere
0.650 0.350 0.000
M12 Other specific arthropathies
0.650 0.350 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.650 0.350 0.000
M08 Juvenile arthritis
0.650 0.350 0.000
M07 Psoriatic and enteropathic arthropathies
0.650 0.350 0.000
M05 Seropositive rheumatoid arthritis
0.650 0.350 0.000
Y84.6 Urinary catheterisation
0.650 0.350 0.000
S82.4 Fracture of fibula alone
0.649 0.351 0.000
D17.0 Benign lipomatous neoplasm of skin and subcutaneous tissue of head, face and neck
0.649 0.351 0.000
M19.97 Arthrosis, unspecified (Ankle and foot)
0.648 0.352 0.000
T85.9 Unspecified complication of internal prosthetic device, implant and graft
0.648 0.352 0.000
T85.6 Mechanical complication of other specified internal prosthetic devices, implants and grafts
0.648 0.352 0.000
T85.5 Mechanical complication of gastro-intestinal prosthetic devices, implants and grafts
0.648 0.352 0.000
T85.3 Mechanical complication of other ocular prosthetic devices, imnplants and grafts
0.648 0.352 0.000
T85.2 Mechanical complication of intraocular lens
0.648 0.352 0.000
T85.1 Mechanical complication of implanted electronic stimulator of nervous system
0.648 0.352 0.000
T85.0 Mechanical complication of ventricular intracranial (communicating) shunt
0.648 0.352 0.000
K76.9 Liver disease, unspecified
0.646 0.353 0.000
R41.8 Other and unspecified symptoms and signs involving cognitive functions and awareness
0.646 0.354 0.000
M25.5 Pain in joint
0.646 0.354 0.000
M19.93 Arthrosis, unspecified (Forearm)
0.646 0.354 0.000
R72 Abnormality of white blood cells, not elsewhere classified
0.646 0.354 0.000
G40 Epilepsy
0.646 0.354 0.000
M25.79 Osteophyte (Site unspecified)
0.646 0.354 0.000
M25.73 Osteophyte (Forearm)
0.646 0.354 0.000
M25.72 Osteophyte (Upper arm)
0.646 0.354 0.000
M25.71 Osteophyte (Shoulder region)
0.646 0.354 0.000
M25.70 Osteophyte (Multiple sites)
0.646 0.354 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.646 0.354 0.000
O13 Gestational [pregnancy-induced] hypertension without significant proteinuria
0.645 0.355 0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.644 0.355 0.000
A00-A09 Intestinal infectious diseases
0.644 0.356 0.000
B35-B49 Mycoses
0.643 0.356 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.643 0.357 0.000
M75.8 Other shoulder lesions
0.642 0.358 0.000
M75.9 Shoulder lesion, unspecified
0.642 0.358 0.000
F40 Phobic anxiety disorders
0.641 0.359 0.000
O47 False labour
0.641 0.359 0.000
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)
0.641 0.359 0.000
R47 Speech disturbances, not elsewhere classified
0.640 0.360 0.000
Y83.9 Surgical procedure, unspecified
0.640 0.360 0.000
D23.3 Skin of other and unspecified parts of face
0.640 0.360 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.639 0.361 0.000
F06.7 Mild cognitive disorder
0.637 0.362 0.000
O02.1 Missed abortion
0.637 0.363 0.000
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level
0.637 0.363 0.000
F05 Delirium, not induced by alcohol and other psychoactive substances
0.636 0.364 0.000
D80-D89 Certain disorders involving the immune mechanism
0.635 0.364 0.000
G55 Nerve root and plexus compressions in diseases classified elsewhere
0.635 0.365 0.000
R41.2 Retrograde amnesia
0.635 0.365 0.000
R41.1 Anterograde amnesia
0.635 0.365 0.000
S83.5 Sprain and strain involving (anterior)(posterior) cruciate ligament of knee
0.635 0.365 0.000
G62.9 Polyneuropathy, unspecified
0.635 0.365 0.000
M11 Other crystal arthropathies
0.635 0.365 0.000
M65 Synovitis and tenosynovitis
0.635 0.365 0.000
I70 Atherosclerosis
0.635 0.365 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.634 0.365 0.000
K29.0 Acute haemorrhagic gastritis
0.634 0.366 0.000
I78 Diseases of capillaries
0.634 0.366 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.634 0.366 0.000
K75.8 Other specified inflammatory liver diseases
0.634 0.366 0.000
H42 Glaucoma in diseases classified elsewhere
0.634 0.366 0.000
M47.8 Other spondylosis
0.634 0.366 0.000
G47 Sleep disorders
0.633 0.367 0.000
A41 Other septicaemia
0.633 0.367 0.000
K25.3 Acute without haemorrhage or perforation
0.633 0.367 0.000
K31.1 Adult hypertrophic pyloric stenosis
0.632 0.368 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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