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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs115225351
log Bayes Factor = 34.2094
Chromosome 4   position 110,732,386  (GRCh37) Explore rs115225351 on Ensembl!
Variant rs115225351 is part of Cluster X0205

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status
1.000 0.000 0.000
Chapter XXI Factors influencing health status and contact with health services
1.000 0.000 0.000
Chapter X Diseases of the respiratory system
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
1.000 0.000 0.000
J40-J47 Chronic lower respiratory diseases
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
I20-I25 Ischaemic heart diseases
0.999 0.001 0.000
J44 Other chronic obstructive pulmonary disease
0.998 0.002 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.998 0.002 0.000
Chapter I Certain infectious and parasitic diseases
0.997 0.003 0.000
Z86 Personal history of certain other diseases
0.997 0.003 0.000
B95-B98 Bacterial, viral and other infectious agents
0.995 0.005 0.000
Z92 Personal history of medical treatment
0.994 0.006 0.000
Chapter XI Diseases of the digestive system
0.993 0.007 0.000
R10-R19 Symptoms and signs involving the digestive system and abdomen
0.992 0.008 0.000
I30-I52 Other forms of heart disease
0.991 0.009 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.991 0.009 0.000
B96 Other bacterial agents as the cause of diseases classified to other chapters
0.988 0.012 0.000
E70-E90 Metabolic disorders
0.987 0.013 0.000
Z92.2 Personal history of long-term (current) use of other medicaments
0.985 0.015 0.000
I25 Chronic ischaemic heart disease
0.984 0.016 0.000
I20 Angina pectoris
0.983 0.017 0.000
Chapter VI Diseases of the nervous system
0.983 0.017 0.000
J44.9 Chronic obstructive pulmonary disease, unspecified
0.982 0.018 0.000
Z86.7 Personal history of diseases of the circulatory system
0.982 0.018 0.000
I50 Heart failure
0.979 0.021 0.000
J90-J94 Other diseases of pleura
0.978 0.022 0.000
Z00-Z13 Persons encountering health services for examination and investigation
0.977 0.023 0.000
M45-M49 Spondylopathies
0.977 0.023 0.000
Z09 Follow-up examination after treatment for conditions other than malignant neoplasms
0.971 0.029 0.000
R50-R69 General symptoms and signs
0.971 0.029 0.000
R10 Abdominal and pelvic pain
0.968 0.032 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.967 0.033 0.000
J95-J99 Other diseases of the respiratory system
0.964 0.036 0.000
K50-K52 Noninfective enteritis and colitis
0.958 0.042 0.000
Z09.0 Follow-up examination after surgery for other conditions
0.957 0.043 0.000
J90 Pleural effusion, not elsewhere classified
0.955 0.045 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.954 0.046 0.000
B96.8 Other specified bacterial agents as the cause of diseases classified to other chapters
0.954 0.046 0.000
R10.1 Pain localised to upper abdomen
0.953 0.047 0.000
R19 Other symptoms and signs involving the digestive system and abdomen
0.953 0.047 0.000
Z91 Personal history of risk-factors, not elsewhere classified
0.953 0.047 0.000
M48 Other spondylopathies
0.951 0.049 0.000
J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified
0.950 0.050 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.950 0.050 0.000
O60-O75 Complications of labour and delivery
0.949 0.051 0.000
G40-G47 Episodic and paroxysmal disorders
0.949 0.051 0.000
Chapter XX External causes of morbidity and mortality
0.945 0.055 0.000
I50.1 Left ventricular failure
0.940 0.060 0.000
Z87 Personal history of other diseases and conditions
0.938 0.062 0.000
J98 Other respiratory disorders
0.938 0.062 0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters
0.937 0.063 0.000
M70-M79 Other soft tissue disorders
0.936 0.064 0.000
E78.5 Hyperlipidaemia, unspecified
0.936 0.064 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.936 0.064 0.000
R19.4 Change in bowel habit
0.934 0.066 0.000
I50.0 Congestive heart failure
0.933 0.067 0.000
M48.0 Spinal stenosis
0.933 0.067 0.000
K55-K64 Other diseases of intestines
0.932 0.068 0.000
M50-M54 Other dorsopathies
0.931 0.069 0.000
I25.2 Old myocardial infarction
0.928 0.072 0.000
K20-K31 Diseases of oesophagus, stomach and duodenum
0.927 0.073 0.000
J30-J39 Other diseases of upper respiratory tract
0.927 0.073 0.000
R30-R39 Symptoms and signs involving the urinary system
0.927 0.073 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.926 0.074 0.000
J98.1 Pulmonary collapse
0.923 0.077 0.000
Chapter II Neoplasms
0.919 0.081 0.000
Z91.5 Personal history of self-harm
0.916 0.084 0.000
K62 Other diseases of anus and rectum
0.914 0.086 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.912 0.088 0.000
Z70-Z76 Persons encountering health services in other circumstances
0.910 0.090 0.000
M15-M19 Arthrosis
0.909 0.091 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.907 0.093 0.000
Z40-Z54 Persons encountering health services for specific procedures and health care
0.907 0.093 0.000
K29 Gastritis and duodenitis
0.907 0.093 0.000
Z86.4 Personal history of psychoactive substance abuse
0.905 0.095 0.000
K59 Other functional intestinal disorders
0.905 0.095 0.000
I20.8 Other forms of angina pectoris
0.905 0.095 0.000
B96.2 Escherichia coli [E. coli] as the cause of diseases classified to other chapters
0.904 0.096 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.902 0.098 0.000
M54 Dorsalgia
0.902 0.098 0.000
R59 Enlarged lymph nodes
0.900 0.100 0.000
K21 Gastro-oesophageal reflux disease
0.898 0.102 0.000
I20.9 Angina pectoris, unspecified
0.897 0.103 0.000
K50 Crohn's disease [regional enteritis]
0.896 0.104 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.892 0.108 0.000
K62.5 Haemorrhage of anus and rectum
0.891 0.109 0.000
I25.8 Other forms of chronic ischaemic heart disease
0.888 0.112 0.000
K59.0 Constipation
0.888 0.112 0.000
Z82 Family history of certain disabilities and chronic diseases leading to disablement
0.887 0.113 0.000
E10-E14 Diabetes mellitus
0.886 0.114 0.000
Z95 Presence of cardiac and vascular implants and grafts
0.877 0.123 0.000
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts
0.875 0.125 0.000
Z51 Other medical care
0.874 0.126 0.000
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection
0.874 0.126 0.000
M40-M43 Deforming dorsopathies
0.873 0.127 0.000
Z86.5 Personal history of other mental and behavioural disorders
0.872 0.128 0.000
Z12 Special screening examination for neoplasms
0.870 0.130 0.000
S70-S79 Injuries to the hip and thigh
0.869 0.131 0.000
Chapter VII Diseases of the eye and adnexa
0.869 0.131 0.000
G40 Epilepsy
0.868 0.132 0.000
I35 Nonrheumatic aortic valve disorders
0.868 0.132 0.000
I49 Other cardiac arrhythmias
0.868 0.132 0.000
R33 Retention of urine
0.867 0.133 0.000
S80-S89 Injuries to the knee and lower leg
0.865 0.135 0.000
Chapter XIV Diseases of the genitourinary system
0.863 0.137 0.000
J47 Bronchiectasis
0.861 0.139 0.000
R52 Pain, not elsewhere classified
0.861 0.139 0.000
I73 Other peripheral vascular diseases
0.861 0.139 0.000
M19 Other arthrosis
0.861 0.139 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.860 0.139 0.000
M48.06 Spinal stenosis (Lumbar region)
0.858 0.142 0.000
R59.0 Localised enlarged lymph nodes
0.858 0.142 0.000
Z87.4 Personal history of diseases of the genito-urinary system
0.857 0.143 0.000
S00-S09 Injuries to the head
0.856 0.144 0.000
O68 Labour and delivery complicated by foetal stress [distress]
0.855 0.145 0.000
R10.2 Pelvic and perineal pain
0.852 0.148 0.000
Z86.0 Personal history of other neoplasms
0.851 0.149 0.000
Z92.1 Personal history of long-term (current) use of anticoagulants
0.851 0.149 0.000
B95.6 Staphylococcus aureus as the cause of diseases classified to other chapters
0.849 0.151 0.000
K90-K93 Other diseases of the digestive system
0.846 0.154 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.846 0.154 0.000
N20-N23 Urolithiasis
0.845 0.155 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.844 0.156 0.000
I22 Subsequent myocardial infarction
0.843 0.157 0.000
E78.0 Pure hypercholesterolaemia
0.843 0.157 0.000
M80-M85 Disorders of bone density and structure
0.843 0.157 0.000
M79.6 Pain in limb
0.840 0.160 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.839 0.161 0.000
K52 Other non-infective gastro-enteritis and colitis
0.839 0.161 0.000
Z87.0 Personal history of diseases of the respiratory system
0.838 0.162 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.837 0.163 0.000
B96.5 Pseudomonas (aeruginosa)(mallei)(pseudomallei) as the cause of diseases classified to other chapters
0.837 0.163 0.000
K40-K46 Hernia
0.836 0.164 0.000
E65-E68 Obesity and other hyperalimentation
0.833 0.167 0.000
K29.6 Other gastritis
0.833 0.167 0.000
R32 Unspecified urinary incontinence
0.832 0.168 0.000
I20.0 Unstable angina
0.832 0.168 0.000
D00-D09 In situ neoplasms
0.830 0.169 0.000
Z09.8 Follow-up examination after other treatment for other conditions
0.829 0.171 0.000
T84.0 Mechanical complication of internal joint prosthesis
0.826 0.174 0.000
K21.0 Gastro-oesophageal reflux disease with oesophagitis
0.825 0.175 0.000
R26 Abnormalities of gait and mobility
0.825 0.175 0.000
I31 Other diseases of pericardium
0.824 0.176 0.000
K21.9 Gastro-oesophageal reflux disease without oesophagitis
0.824 0.176 0.000
M19.9 Arthrosis, unspecified
0.823 0.177 0.000
Z99 Dependence on enabling machines and devices, not elsewhere classified
0.823 0.177 0.000
J40 Bronchitis, not specified as acute or chronic
0.823 0.177 0.000
E10 Insulin-dependent diabetes mellitus
0.823 0.177 0.000
M20-M25 Other joint disorders
0.819 0.181 0.000
O00-O08 Pregnancy with abortive outcome
0.818 0.182 0.000
Z51.5 Palliative care
0.818 0.182 0.000
R54 Senility
0.818 0.182 0.000
E86 Volume depletion
0.816 0.184 0.000
M48.02 Spinal stenosis (Cervical region)
0.816 0.184 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.816 0.184 0.000
J45 Asthma
0.815 0.185 0.000
Chapter XXII Codes for special purposes
0.814 0.186 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.813 0.186 0.000
Z75 Problems related to medical facilities and other health care
0.813 0.187 0.000
R25 Abnormal involuntary movements
0.813 0.187 0.000
R60 Oedema, not elsewhere classified
0.812 0.188 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.811 0.189 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.811 0.189 0.000
R16 Hepatomegaly and splenomegaly, not elsewhere classified
0.809 0.190 0.000
I35.0 Aortic (valve) stenosis
0.809 0.191 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.808 0.192 0.000
S40-S49 Injuries to the shoulder and upper arm
0.807 0.193 0.000
J33 Nasal polyp
0.807 0.193 0.000
Z80 Family history of malignant neoplasm
0.805 0.195 0.000
R11 Nausea and vomiting
0.803 0.197 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.803 0.197 0.000
Z93 Artificial opening status
0.801 0.199 0.000
B25-B34 Other viral diseases
0.800 0.200 0.000
Z09.7 Follow-up examination after combined treatment for other conditions
0.800 0.200 0.000
B95.1 Streptococcus, group B, as the cause of diseases classified to other chapters
0.799 0.201 0.000
G90-G99 Other disorders of the nervous system
0.798 0.202 0.000
M47 Spondylosis
0.798 0.202 0.000
Z95.5 Presence of coronary angioplasty implant and graft
0.797 0.203 0.000
Z51.8 Other specified medical care
0.795 0.205 0.000
I73.9 Peripheral vascular disease, unspecified
0.795 0.205 0.000
Z81 Family history of mental and behavioural disorders
0.794 0.206 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.794 0.206 0.000
G44 Other headache syndromes
0.794 0.206 0.000
Z12.1 Special screening examination for neoplasm of intestinal tract
0.794 0.206 0.000
R50 Fever of unknown origin
0.793 0.207 0.000
K50.1 Crohn's disease of large intestine
0.792 0.208 0.000
R29 Other symptoms and signs involving the nervous and musculoskeletal systems
0.791 0.209 0.000
N20 Calculus of kidney and ureter
0.791 0.209 0.000
J94 Other pleural conditions
0.789 0.211 0.000
D60-D64 Aplastic and other anaemias
0.789 0.211 0.000
R51 Headache
0.786 0.214 0.000
Z92.3 Personal history of irradiation
0.784 0.216 0.000
K50.9 Crohn's disease, unspecified
0.783 0.217 0.000
M54.9 Dorsalgia, unspecified
0.783 0.217 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.782 0.218 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
0.782 0.218 0.000
M48.07 Spinal stenosis (Lumbosacral region)
0.781 0.219 0.000
Z82.4 Family history of ischaemic heart disease and other diseases of the circulatory system
0.781 0.219 0.000
I05-I09 Chronic rheumatic heart diseases
0.781 0.219 0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases
0.780 0.219 0.000
B97 Viral agents as the cause of diseases classified to other chapters
0.778 0.222 0.000
Z94 Transplanted organ and tissue status
0.777 0.223 0.000
S60-S69 Injuries to the wrist and hand
0.777 0.223 0.000
K25 Gastric ulcer
0.776 0.224 0.000
Z98 Other postsurgical states
0.776 0.224 0.000
D50-D53 Nutritional anaemias
0.776 0.224 0.000
J44.8 Other specified chronic obstructive pulmonary disease
0.776 0.224 0.000
S72 Fracture of femur
0.776 0.224 0.000
E20-E35 Disorders of other endocrine glands
0.776 0.224 0.000
K29.1 Other acute gastritis
0.774 0.226 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.774 0.226 0.000
Z04 Examination and observation for other reasons
0.774 0.226 0.000
M79.7 Fibromyalgia
0.772 0.228 0.000
N25-N29 Other disorders of kidney and ureter
0.772 0.228 0.000
K29.5 Chronic gastritis, unspecified
0.771 0.229 0.000
M54.2 Cervicalgia
0.769 0.230 0.000
R63 Symptoms and signs concerning food and fluid intake
0.768 0.232 0.000
O63 Long labour
0.767 0.233 0.000
K62.0 Anal polyp
0.767 0.233 0.000
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
0.767 0.233 0.000
T39.1 4-Aminophenol derivatives
0.766 0.234 0.000
S50-S59 Injuries to the elbow and forearm
0.766 0.234 0.000
K52.9 Non-infective gastro-enteritis and colitis, unspecified
0.766 0.234 0.000
J39 Other diseases of upper respiratory tract
0.766 0.234 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.765 0.235 0.000
O75 Other complications of labour and delivery, not elsewhere classified
0.764 0.236 0.000
I25.1 Atherosclerotic heart disease
0.761 0.239 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.761 0.239 0.000
M43 Other deforming dorsopathies
0.759 0.241 0.000
N23 Unspecified renal colic
0.758 0.242 0.000
Z51.2 Other chemotherapy
0.758 0.242 0.000
I25.9 Chronic ischaemic heart disease, unspecified
0.757 0.243 0.000
J93 Pneumothorax
0.757 0.243 0.000
Z52 Donors of organs and tissues
0.756 0.244 0.000
E50-E64 Other nutritional deficiencies
0.755 0.244 0.000
R52.1 Chronic intractable pain
0.755 0.245 0.000
R15 Faecal incontinence
0.754 0.246 0.000
R10.0 Acute abdomen
0.754 0.246 0.000
H30-H36 Disorders of choroid and retina
0.754 0.246 0.000
S90-S99 Injuries to the ankle and foot
0.753 0.247 0.000
J43 Emphysema
0.753 0.247 0.000
M54.5 Low back pain
0.753 0.247 0.000
W00-W19 Falls
0.752 0.248 0.000
I73.0 Raynaud's syndrome
0.752 0.248 0.000
S20-S29 Injuries to the thorax
0.751 0.248 0.000
M79.60 Pain in limb (Multiple sites)
0.751 0.249 0.000
O80-O84 Delivery
0.751 0.249 0.000
G47 Sleep disorders
0.750 0.250 0.000
B35-B49 Mycoses
0.749 0.251 0.000
M48.09 Spinal stenosis (Site unspecified)
0.749 0.251 0.000
K62.7 Radiation proctitis
0.749 0.251 0.000
K43 Ventral hernia
0.748 0.252 0.000
Z92.6 Personal history of chemotherapy for neoplastic disease
0.747 0.253 0.000
O64 Obstructed labour due to malposition and malpresentation of foetus
0.747 0.253 0.000
K62.3 Rectal prolapse
0.747 0.253 0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis
0.746 0.254 0.000
G45 Transient cerebral ischaemic attacks and related syndromes
0.746 0.254 0.000
D06 Carcinoma in situ of cervix uteri
0.745 0.255 0.000
I20.1 Angina pectoris with documented spasm
0.744 0.256 0.000
Z75.1 Person awaiting admission to adequate facility elsewhere
0.744 0.256 0.000
I38 Endocarditis, valve unspecified
0.742 0.257 0.000
M79.65 Pain in limb (Pelvic region and thigh)
0.742 0.258 0.000
J20-J22 Other acute lower respiratory infections
0.742 0.258 0.000
B96.1 Klebsiella pneumoniae [K. pneumoniae] as the cause of diseases classified to other chapters
0.742 0.258 0.000
J32 Chronic sinusitis
0.742 0.258 0.000
I25.5 Ischaemic cardiomyopathy
0.741 0.259 0.000
E10.9 Without complications
0.741 0.259 0.000
J34 Other disorders of nose and nasal sinuses
0.739 0.261 0.000
Z95.1 Presence of aortocoronary bypass graft
0.737 0.263 0.000
Z71 Persons encountering health services for other counselling and medical advice, not elsewhere classified
0.736 0.264 0.000
T79-T79 Certain early complications of trauma
0.736 0.264 0.000
R26.8 Other and unspecified abnormalities of gait and mobility
0.736 0.264 0.000
N60-N64 Disorders of breast
0.735 0.265 0.000
J09-J18 Influenza and pneumonia
0.735 0.265 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.734 0.266 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.734 0.266 0.000
H43-H45 Disorders of vitreous body and globe
0.734 0.266 0.000
J00-J06 Acute upper respiratory infections
0.733 0.267 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.732 0.268 0.000
M65-M68 Disorders of synovium and tendon
0.732 0.268 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.732 0.268 0.000
J42 Unspecified chronic bronchitis
0.731 0.268 0.000
I22.9 Subsequent myocardial infarction of unspecified site
0.731 0.269 0.000
Z91.0 Personal history of allergy, other than to drugs and biological substances
0.731 0.269 0.000
S82 Fracture of lower leg, including ankle
0.729 0.271 0.000
J33.0 Polyp of nasal cavity
0.728 0.272 0.000
Y43 Primarily systemic agents
0.728 0.272 0.000
I49.9 Cardiac arrhythmia, unspecified
0.726 0.274 0.000
I24 Other acute ischaemic heart diseases
0.726 0.274 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.725 0.275 0.000
O68.8 Labour and delivery complicated by other evidence of foetal stress
0.725 0.275 0.000
A30-A49 Other bacterial diseases
0.725 0.275 0.000
E83 Disorders of mineral metabolism
0.723 0.277 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.723 0.277 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.722 0.278 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.721 0.279 0.000
K92 Other diseases of digestive system
0.721 0.279 0.000
O62 Abnormalities of forces of labour
0.721 0.279 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.721 0.279 0.000
M54.3 Sciatica
0.721 0.279 0.000
R30 Pain associated with micturition
0.720 0.280 0.000
O72 Postpartum haemorrhage
0.720 0.280 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.719 0.281 0.000
M71 Other bursopathies
0.718 0.282 0.000
K29.7 Gastritis, unspecified
0.717 0.283 0.000
Z97 Presence of other devices
0.717 0.283 0.000
Z89 Acquired absence of limb
0.717 0.283 0.000
Z84 Family history of other conditions
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
M91-M94 Chondropathies
0.717 0.283 0.000
M60-M63 Disorders of muscles
0.717 0.283 0.000
M00-M03 Infectious arthropathies
0.717 0.283 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.717 0.283 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.717 0.283 0.000
J41 Simple and mucopurulent chronic bronchitis
0.717 0.283 0.000
J46 Status asthmaticus
0.717 0.283 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.717 0.283 0.000
T66-T78 Other and unspecified effects of external causes
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.717 0.283 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.717 0.283 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
S10-S19 Injuries to the neck
0.717 0.283 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.717 0.283 0.000
G20-G26 Extrapyramidal and movement disorders
0.716 0.283 0.000
I23 Certain current complications following acute myocardial infarction
0.716 0.284 0.000
M79.8 Other specified soft tissue disorders
0.716 0.284 0.000
K62.9 Disease of anus and rectum, unspecified
0.716 0.284 0.000
E40-E46 Malnutrition
0.715 0.284 0.000
A00-A09 Intestinal infectious diseases
0.716 0.284 0.000
E66 Obesity
0.715 0.285 0.000
M22 Disorders of patella
0.715 0.285 0.000
B99-B99 Other infectious diseases
0.715 0.285 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.715 0.285 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.715 0.285 0.000
B65-B83 Helminthiases
0.715 0.285 0.000
B50-B64 Protozoal diseases
0.715 0.285 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.715 0.285 0.000
B15-B19 Viral hepatitis
0.715 0.285 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.715 0.285 0.000
A80-A89 Viral infections of the central nervous system
0.715 0.285 0.000
A75-A79 Rickettsioses
0.715 0.285 0.000
A70-A74 Other diseases caused by chlamydiae
0.715 0.285 0.000
A65-A69 Other spirochaetal diseases
0.715 0.285 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.715 0.285 0.000
A20-A28 Certain zoonotic bacterial diseases
0.715 0.285 0.000
A15-A19 Tuberculosis
0.715 0.285 0.000
Z86.2 Personal history of diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.715 0.285 0.000
D10-D36 Benign neoplasms
0.714 0.286 0.000
R12 Heartburn
0.714 0.286 0.000
N20.0 Calculus of kidney
0.713 0.287 0.000
Z92.9 Personal history of medical treatment, unspecified
0.712 0.288 0.000
Z92.8 Personal history of other medical treatment
0.712 0.288 0.000
Z92.5 Personal history of rehabilitation measures
0.712 0.288 0.000
Z92.0 Personal history of contraception
0.712 0.288 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.712 0.288 0.000
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle
0.712 0.288 0.000
G40.3 Generalised idiopathic epilepsy and epileptic syndromes
0.711 0.289 0.000
E87.6 Hypokalaemia
0.711 0.289 0.000
M19.91 Arthrosis, unspecified (Shoulder region)
0.711 0.289 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.711 0.289 0.000
I52 Other heart disorders in diseases classified elsewhere
0.710 0.289 0.000
I48 Atrial fibrillation and flutter
0.710 0.289 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.710 0.289 0.000
I41 Myocarditis in diseases classified elsewhere
0.710 0.289 0.000
I40 Acute myocarditis
0.710 0.289 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.710 0.289 0.000
I37 Pulmonary valve disorders
0.710 0.289 0.000
I36 Nonrheumatic tricuspid valve disorders
0.710 0.289 0.000
I33 Acute and subacute endocarditis
0.710 0.289 0.000
I32 Pericarditis in diseases classified elsewhere
0.710 0.289 0.000
I30 Acute pericarditis
0.710 0.289 0.000
O85-O92 Complications predominantly related to the puerperium
0.710 0.289 0.000
Z99.1 Dependence on respirator
0.710 0.290 0.000
M79.62 Pain in limb (Upper arm)
0.710 0.290 0.000
T84.1 Mechanical complication of internal fixation device of bones of limb
0.710 0.290 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.709 0.290 0.000
Chapter V Mental and behavioural disorders
0.709 0.291 0.000
M77 Other enthesopathies
0.709 0.291 0.000
B96.7 Clostridium perfringens [C. perfringens] as the cause of diseases classified to other chapters
0.709 0.291 0.000
B96.6 Bacillus fragilis [B. fragilis] as the cause of diseases classified to other chapters
0.709 0.291 0.000
B96.4 Proteus (mirabilis)(morganii) as the cause of diseases classified to other chapters
0.709 0.291 0.000
B96.3 Haemophilus influenzae [H. influenzae] as the cause of diseases classified to other chapters
0.709 0.291 0.000
B96.0 Mycoplasma pneumoniae [M. pneumoniae] as the cause of diseases classified to other chapters
0.709 0.291 0.000
G40.9 Epilepsy, unspecified
0.709 0.291 0.000
Z80.1 Family history of malignant neoplasm of trachea, bronchus and lung
0.709 0.291 0.000
Chapter VIII Diseases of the ear and mastoid process
0.708 0.292 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.708 0.292 0.000
Z43 Attention to artificial openings
0.708 0.292 0.000
Z86.6 Personal history of diseases of the nervous system and sense organs
0.708 0.292 0.000
E88 Other metabolic disorders
0.707 0.292 0.000
E85 Amyloidosis
0.707 0.292 0.000
E84 Cystic fibrosis
0.707 0.292 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.707 0.292 0.000
E79 Disorders of purine and pyrimidine metabolism
0.707 0.292 0.000
E77 Disorders of glycoprotein metabolism
0.707 0.292 0.000
E76 Disorders of glycosaminoglycan metabolism
0.707 0.292 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.707 0.292 0.000
E74 Other disorders of carbohydrate metabolism
0.707 0.292 0.000
E73 Lactose intolerance
0.707 0.292 0.000
E72 Other disorders of amino-acid metabolism
0.707 0.292 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.707 0.292 0.000
E70 Disorders of aromatic amino-acid metabolism
0.707 0.292 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.707 0.292 0.000
G55 Nerve root and plexus compressions in diseases classified elsewhere
0.707 0.293 0.000
I46 Cardiac arrest
0.707 0.293 0.000
T84.6 Infection and inflammatory reaction due to internal fixation device [any site]
0.707 0.293 0.000
Z93.2 Ileostomy status
0.707 0.293 0.000
I45 Other conduction disorders
0.707 0.293 0.000
N28 Other disorders of kidney and ureter, not elsewhere classified
0.707 0.293 0.000
B95.5 Unspecified streptococcus as the cause of diseases classified to other chapters
0.706 0.294 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.706 0.294 0.000
R60.0 Localised oedema
0.706 0.294 0.000
I25.6 Silent myocardial ischaemia
0.705 0.295 0.000
I25.4 Coronary artery aneurysm
0.705 0.295 0.000
I25.3 Aneurysm of heart
0.705 0.295 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.705 0.295 0.000
M79.0 Rheumatism, unspecified
0.705 0.295 0.000
G40.1 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
0.705 0.295 0.000
M16 Coxarthrosis [arthrosis of hip]
0.705 0.295 0.000
O26 Maternal care for other conditions predominantly related to pregnancy
0.705 0.295 0.000
G70-G73 Diseases of myoneural junction and muscle
0.705 0.295 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.705 0.295 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.705 0.295 0.000
I31.3 Pericardial effusion (noninflammatory)
0.704 0.296 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.704 0.296 0.000
H53-H54 Visual disturbances and blindness
0.703 0.297 0.000
K55 Vascular disorders of intestine
0.702 0.297 0.000
S09 Other and unspecified injuries of head
0.702 0.298 0.000
Z82.0 Family history of epilepsy and other diseases of the nervous system
0.702 0.298 0.000
B95.7 Other staphylococcus as the cause of diseases classified to other chapters
0.702 0.298 0.000
M86-M90 Other osteopathies
0.702 0.298 0.000
O99.0 Anaemia complicating pregnancy, childbirth and the puerperium
0.702 0.298 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.702 0.298 0.000
J91 Pleural effusion in conditions classified elsewhere
0.701 0.298 0.000
M18 Arthrosis of first carpometacarpal joint
0.701 0.299 0.000
Z10 Routine general health check-up of defined subpopulation
0.701 0.299 0.000
O68.0 Labour and delivery complicated by foetal heart rate anomaly
0.700 0.299 0.000
R25.2 Cramp and spasm
0.700 0.299 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.700 0.300 0.000
M49 Spondylopathies in diseases classified elsewhere
0.700 0.300 0.000
M46 Other inflammatory spondylopathies
0.700 0.300 0.000
M45 Ankylosing spondylitis
0.700 0.300 0.000
Z87.7 Personal history of congenital malformations, deformations and chromosomal abnormalities
0.700 0.300 0.000
R29.8 Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
0.700 0.300 0.000
K51 Ulcerative colitis
0.700 0.300 0.000
O03 Spontaneous abortion
0.699 0.301 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.699 0.301 0.000
K44 Diaphragmatic hernia
0.698 0.302 0.000
D50 Iron deficiency anaemia
0.697 0.302 0.000
S00 Superficial injury of head
0.697 0.303 0.000
G43 Migraine
0.696 0.303 0.000
M54.1 Radiculopathy
0.696 0.304 0.000
Z09.4 Follow-up examination after treatment of fracture
0.696 0.304 0.000
Z09.3 Follow-up examination after psychotherapy
0.696 0.304 0.000
Z09.1 Follow-up examination after radiotherapy for other conditions
0.696 0.304 0.000
R68 Other general symptoms and signs
0.696 0.304 0.000
R65 Systemic Inflammatory Response Syndrome [SIRS]
0.696 0.304 0.000
R62 Lack of expected normal physiological development
0.696 0.304 0.000
R57 Shock, not elsewhere classified
0.696 0.304 0.000
R64 Cachexia
0.696 0.304 0.000
R58 Haemorrhage, not elsewhere classified
0.696 0.304 0.000
M54.99 Dorsalgia, unspecified (Site unspecified)
0.695 0.305 0.000
N20.1 Calculus of ureter
0.694 0.306 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.694 0.306 0.000
N99-N99 Other disorders of the genitourinary system
0.694 0.306 0.000
E78.9 Disorder of lipoprotein metabolism, unspecified
0.693 0.306 0.000
E78.8 Other disorders of lipoprotein metabolism
0.693 0.306 0.000
E78.6 Lipoprotein deficiency
0.693 0.306 0.000
E78.4 Other hyperlipidaemia
0.693 0.306 0.000
E78.3 Hyperchylomicronaemia
0.693 0.306 0.000
E78.2 Mixed hyperlipidaemia
0.693 0.306 0.000
E78.1 Pure hyperglyceridaemia
0.693 0.306 0.000
D45 Polycythaemia vera
0.693 0.307 0.000
W20-W49 Exposure to inanimate mechanical forces
0.693 0.307 0.000
Z51.3 Blood transfusion without reported diagnosis
0.693 0.307 0.000
Z87.1 Personal history of diseases of the digestive system
0.692 0.308 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.692 0.308 0.000
J99 Respiratory disorders in diseases classified elsewhere
0.691 0.309 0.000
J96 Respiratory failure, not elsewhere classified
0.691 0.309 0.000
J95 Postprocedural respiratory disorders, not elsewhere classified
0.691 0.309 0.000
Z09.9 Follow-up examination after unspecified treatment for other conditions
0.690 0.310 0.000
R27 Other lack of coordination
0.690 0.310 0.000
O68.2 Labour and delivery complicated by foetal heart rate anomaly with meconium in amniotic fluid
0.688 0.312 0.000
K29.0 Acute haemorrhagic gastritis
0.688 0.312 0.000
M19.97 Arthrosis, unspecified (Ankle and foot)
0.687 0.313 0.000
R19.8 Other specified symptoms and signs involving the digestive system and abdomen
0.687 0.313 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.687 0.313 0.000
H55-H59 Other disorders of eye and adnexa
0.687 0.313 0.000
J31 Chronic rhinitis, nasopharyngitis and pharyngitis
0.686 0.313 0.000
Z11 Special screening examination for infectious and parasitic diseases
0.686 0.314 0.000
M19.99 Arthrosis, unspecified (Site unspecified)
0.685 0.314 0.000
N21 Calculus of lower urinary tract
0.685 0.315 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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