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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs11645236
log Bayes Factor = 19.5773
Chromosome 16   position 54,713,198  (GRCh37) Explore rs11645236 on Ensembl!
Variant rs11645236 is part of Cluster X0148

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter VII Diseases of the eye and adnexa
1.000 0.000 0.000
Chapter II Neoplasms
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.999 0.001 0.000
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status
0.999 0.001 0.000
R50-R69 General symptoms and signs
0.999 0.001 0.000
Chapter XXI Factors influencing health status and contact with health services
0.998 0.002 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.997 0.003 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.996 0.004 0.000
Z85 Personal history of malignant neoplasm
0.996 0.004 0.000
Z96 Presence of other functional implants
0.996 0.004 0.000
R50 Fever of unknown origin
0.994 0.006 0.000
C43-C44 Melanoma and other malignant neoplasms of skin
0.994 0.006 0.000
D00-D09 In situ neoplasms
0.993 0.007 0.000
R50.9 Fever, unspecified
0.992 0.008 0.000
M20-M25 Other joint disorders
0.991 0.009 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.991 0.009 0.000
Z96.1 Presence of intraocular lens
0.990 0.010 0.000
C43 Malignant melanoma of skin
0.987 0.013 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.986 0.014 0.000
Chapter XX External causes of morbidity and mortality
0.984 0.016 0.000
H52 Disorders of refraction and accommodation
0.981 0.019 0.000
H25-H28 Disorders of lens
0.980 0.020 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.980 0.020 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.976 0.024 0.000
C34 Malignant neoplasm of bronchus and lung
0.975 0.025 0.000
C43.5 Malignant melanoma of trunk
0.974 0.026 0.000
H25 Senile cataract
0.974 0.026 0.000
Z85.8 Personal history of malignant neoplasms of other organs and systems
0.972 0.028 0.000
M70-M79 Other soft tissue disorders
0.970 0.030 0.000
H25.1 Senile nuclear cataract
0.969 0.031 0.000
H30-H36 Disorders of choroid and retina
0.969 0.031 0.000
H52.1 Myopia
0.969 0.031 0.000
R51 Headache
0.968 0.032 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.965 0.035 0.000
M25 Other joint disorders, not elsewhere classified
0.964 0.036 0.000
C34.1 Upper lobe, bronchus or lung
0.961 0.039 0.000
D05 Carcinoma in situ of breast
0.960 0.040 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.956 0.044 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.955 0.045 0.000
Z86 Personal history of certain other diseases
0.953 0.047 0.000
Z85.3 Personal history of malignant neoplasm of breast
0.951 0.049 0.000
Z86.4 Personal history of psychoactive substance abuse
0.946 0.054 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.944 0.056 0.000
H50 Other strabismus
0.941 0.059 0.000
R22 Localised swelling, mass and lump of skin and subcutaneous tissue
0.940 0.060 0.000
H33 Retinal detachments and breaks
0.940 0.060 0.000
H55-H59 Other disorders of eye and adnexa
0.935 0.065 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.934 0.066 0.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes
0.934 0.066 0.000
Y95 Nosocomial condition
0.933 0.067 0.000
R87 Abnormal findings in specimens from female genital organs
0.931 0.069 0.000
Chapter VI Diseases of the nervous system
0.928 0.072 0.000
Z96.0 Presence of urogenital implants
0.927 0.073 0.000
H33.0 Retinal detachment with retinal break
0.925 0.075 0.000
M35 Other systemic involvement of connective tissue
0.921 0.079 0.000
D05.1 Intraductal carcinoma in situ
0.920 0.080 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.917 0.083 0.000
C77.1 Intrathoracic lymph nodes
0.916 0.084 0.000
C43.6 Malignant melanoma of upper limb, including shoulder
0.916 0.084 0.000
R21 Rash and other nonspecific skin eruption
0.912 0.088 0.000
M05-M14 Inflammatory polyarthropathies
0.909 0.091 0.000
R87.6 Abnormal cytological findings
0.908 0.092 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.907 0.093 0.000
C15-C26 Malignant neoplasms of digestive organs
0.907 0.093 0.000
M25.5 Pain in joint
0.907 0.093 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.899 0.101 0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.893 0.107 0.000
C77.5 Intrapelvic lymph nodes
0.888 0.112 0.000
M80-M85 Disorders of bone density and structure
0.886 0.114 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.885 0.115 0.000
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts
0.880 0.120 0.000
D06 Carcinoma in situ of cervix uteri
0.880 0.120 0.000
Z97 Presence of other devices
0.877 0.123 0.000
M35.3 Polymyalgia rheumatica
0.875 0.125 0.000
R61 Hyperhidrosis
0.874 0.126 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.870 0.130 0.000
M31 Other necrotising vasculopathies
0.870 0.130 0.000
T85.8 Other complications of internal prosthetic devices, implants and grafts, not elsewhere classified
0.869 0.131 0.000
S90-S99 Injuries to the ankle and foot
0.868 0.132 0.000
Z86.6 Personal history of diseases of the nervous system and sense organs
0.866 0.134 0.000
H50.9 Strabismus, unspecified
0.866 0.134 0.000
Z83 Family history of other specific disorders
0.865 0.135 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.862 0.138 0.000
R22.4 Localised swelling, mass and lump, lower limb
0.860 0.140 0.000
M65-M68 Disorders of synovium and tendon
0.860 0.140 0.000
M75 Shoulder lesions
0.859 0.141 0.000
H02 Other disorders of eyelid
0.859 0.141 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.856 0.144 0.000
S80-S89 Injuries to the knee and lower leg
0.854 0.146 0.000
S70-S79 Injuries to the hip and thigh
0.854 0.146 0.000
Chapter I Certain infectious and parasitic diseases
0.853 0.147 0.000
Z82 Family history of certain disabilities and chronic diseases leading to disablement
0.853 0.147 0.000
M75.0 Adhesive capsulitis of shoulder
0.852 0.148 0.000
H59 Postprocedural disorders of eye and adnexa, not elsewhere classified
0.849 0.151 0.000
M21 Other acquired deformities of limbs
0.849 0.151 0.000
M13 Other arthritis
0.849 0.151 0.000
T84.9 Unspecified complication of internal orthopaedic prosthetic device, implant and graft
0.845 0.155 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.844 0.156 0.000
R22.3 Localised swelling, mass and lump, upper limb
0.843 0.157 0.000
C81 Hodgkin's disease
0.840 0.160 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.839 0.161 0.000
Z85.4 Personal history of malignant neoplasm of genital organs
0.838 0.162 0.000
H43-H45 Disorders of vitreous body and globe
0.834 0.166 0.000
C34.3 Lower lobe, bronchus or lung
0.831 0.169 0.000
M25.4 Effusion of joint
0.831 0.169 0.000
T84.2 Mechanical complication of internal fixation device of other bones
0.825 0.175 0.000
R59 Enlarged lymph nodes
0.823 0.177 0.000
C51-C58 Malignant neoplasms of female genital organs
0.823 0.177 0.000
T84.0 Mechanical complication of internal joint prosthesis
0.822 0.178 0.000
D07 Carcinoma in situ of other and unspecified genital organs
0.820 0.180 0.000
G30-G32 Other degenerative diseases of the nervous system
0.819 0.181 0.000
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.817 0.183 0.000
M72 Fibroblastic disorders
0.817 0.183 0.000
M84 Disorders of continuity of bone
0.813 0.187 0.000
D04 Carcinoma in situ of skin
0.813 0.187 0.000
Z91 Personal history of risk-factors, not elsewhere classified
0.812 0.188 0.000
C44 Other malignant neoplasms of skin
0.809 0.191 0.000
Z63 Other problems related to primary support group, including family circumstances
0.809 0.191 0.000
D05.9 Carcinoma in situ of breast, unspecified
0.808 0.192 0.000
R22.9 Localised swelling, mass and lump, unspecified
0.807 0.193 0.000
M25.53 Pain in joint (Forearm)
0.807 0.193 0.000
R23 Other skin changes
0.807 0.193 0.000
R53 Malaise and fatigue
0.803 0.197 0.000
H10-H13 Disorders of conjunctiva
0.801 0.199 0.000
M13.9 Arthritis, unspecified
0.801 0.199 0.000
M86-M90 Other osteopathies
0.800 0.200 0.000
M25.8 Other specified joint disorders
0.800 0.200 0.000
H02.3 Blepharochalasis
0.800 0.200 0.000
D06.9 Cervix, unspecified
0.799 0.201 0.000
Chapter XXII Codes for special purposes
0.796 0.204 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.795 0.205 0.000
H57 Other disorders of eye and adnexa
0.793 0.207 0.000
T92 Sequelae of injuries of upper limb
0.790 0.210 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.789 0.211 0.000
Z97.8 Presence of other specified devices
0.789 0.211 0.000
H59.8 Other postprocedural disorders of eye and adnexa
0.788 0.212 0.000
C79 Secondary malignant neoplasm of other sites
0.786 0.214 0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis
0.786 0.214 0.000
Chapter V Mental and behavioural disorders
0.786 0.214 0.000
M13.99 Arthritis, unspecified (Site unspecified)
0.786 0.214 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.785 0.215 0.000
Chapter X Diseases of the respiratory system
0.785 0.215 0.000
H34 Retinal vascular occlusions
0.784 0.215 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.783 0.217 0.000
C83 Diffuse non-Hodgkin's lymphoma
0.783 0.217 0.000
M31.6 Other giant cell arteritis
0.783 0.217 0.000
Y83.1 Surgical operation with implant of artificial internal device
0.782 0.218 0.000
M25.59 Pain in joint (Site unspecified)
0.782 0.218 0.000
Z57 Occupational exposure to risk-factors
0.781 0.219 0.000
X60-X84 Intentional self-harm
0.780 0.220 0.000
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts
0.780 0.220 0.000
Z85.6 Personal history of leukaemia
0.780 0.220 0.000
H25.8 Other senile cataract
0.779 0.221 0.000
Y83 Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.778 0.222 0.000
R22.2 Localised swelling, mass and lump, trunk
0.778 0.222 0.000
Z93 Artificial opening status
0.777 0.223 0.000
C19 Malignant neoplasm of rectosigmoid junction
0.777 0.223 0.000
C20 Malignant neoplasm of rectum
0.776 0.224 0.000
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.775 0.225 0.000
A30-A49 Other bacterial diseases
0.774 0.226 0.000
M25.9 Joint disorder, unspecified
0.774 0.226 0.000
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs
0.773 0.227 0.000
V40-V49 Car occupant injured in transport accident
0.773 0.227 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.772 0.228 0.000
H52.0 Hypermetropia
0.770 0.230 0.000
H50.1 Divergent concomitant strabismus
0.769 0.231 0.000
C43.3 Malignant melanoma of other and unspecified parts of face
0.769 0.231 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.769 0.231 0.000
H49 Paralytic strabismus
0.768 0.232 0.000
H33.4 Traction detachment of retina
0.767 0.233 0.000
R52 Pain, not elsewhere classified
0.767 0.233 0.000
Z82.3 Family history of stroke
0.766 0.234 0.000
Z92 Personal history of medical treatment
0.766 0.234 0.000
Z85.2 Personal history of malignant neoplasm of other respiratory and intrathoracic organs
0.765 0.235 0.000
T85.2 Mechanical complication of intraocular lens
0.762 0.238 0.000
M06 Other rheumatoid arthritis
0.762 0.238 0.000
R57 Shock, not elsewhere classified
0.761 0.239 0.000
T91 Sequelae of injuries of neck and trunk
0.761 0.239 0.000
M00-M03 Infectious arthropathies
0.760 0.240 0.000
T84.6 Infection and inflammatory reaction due to internal fixation device [any site]
0.760 0.240 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.760 0.240 0.000
H53-H54 Visual disturbances and blindness
0.760 0.240 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.759 0.241 0.000
Z99 Dependence on enabling machines and devices, not elsewhere classified
0.758 0.242 0.000
H02.1 Ectropion of eyelid
0.757 0.243 0.000
M25.50 Pain in joint (Multiple sites)
0.756 0.244 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.756 0.244 0.000
M25.3 Other instability of joint
0.752 0.247 0.000
M77 Other enthesopathies
0.752 0.248 0.000
C81.9 Hodgkin's disease, unspecified
0.751 0.249 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.750 0.250 0.000
C34.2 Middle lobe, bronchus or lung
0.749 0.251 0.000
G70-G73 Diseases of myoneural junction and muscle
0.749 0.251 0.000
R68 Other general symptoms and signs
0.749 0.251 0.000
M21.2 Flexion deformity
0.748 0.252 0.000
M65 Synovitis and tenosynovitis
0.747 0.253 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.747 0.253 0.000
R61.9 Hyperhidrosis, unspecified
0.746 0.254 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.746 0.254 0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.746 0.254 0.000
M91-M94 Chondropathies
0.745 0.255 0.000
M76 Enthesopathies of lower limb, excluding foot
0.744 0.256 0.000
C44.5 Skin of trunk
0.744 0.256 0.000
M25.46 Effusion of joint (Lower leg)
0.743 0.257 0.000
Chapter XI Diseases of the digestive system
0.742 0.258 0.000
C77.4 Inguinal and lower limb lymph nodes
0.742 0.258 0.000
Z81 Family history of mental and behavioural disorders
0.740 0.260 0.000
H36 Retinal disorders in diseases classified elsewhere
0.740 0.260 0.000
R85 Abnormal findings in specimens from digestive organs and abdominal cavity
0.738 0.262 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.738 0.262 0.000
Z82.6 Family history of arthritis and other diseases of the musculoskeletal system and connective tissue
0.738 0.262 0.000
J84 Other interstitial pulmonary diseases
0.736 0.264 0.000
T90 Sequelae of injuries of head
0.736 0.264 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.736 0.264 0.000
C88 Malignant immunoproliferative diseases
0.735 0.265 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.735 0.265 0.000
C32 Malignant neoplasm of larynx
0.735 0.265 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.735 0.265 0.000
Z83.7 Family history of diseases of the digestive system
0.735 0.265 0.000
H02.5 Other disorders affecting eyelid function
0.734 0.266 0.000
D09 Carcinoma in situ of other and unspecified sites
0.734 0.266 0.000
S92 Fracture of foot, except ankle
0.733 0.267 0.000
H47 Other disorders of optic [2nd] nerve and visual pathways
0.733 0.267 0.000
T85.9 Unspecified complication of internal prosthetic device, implant and graft
0.733 0.267 0.000
C85.7 Other specified types of non-Hodgkin's lymphoma
0.732 0.268 0.000
R55 Syncope and collapse
0.732 0.268 0.000
J20-J22 Other acute lower respiratory infections
0.731 0.269 0.000
H25.0 Senile incipient cataract
0.730 0.270 0.000
C54 Malignant neoplasm of corpus uteri
0.730 0.270 0.000
H52.2 Astigmatism
0.729 0.270 0.000
K90-K93 Other diseases of the digestive system
0.728 0.272 0.000
R58 Haemorrhage, not elsewhere classified
0.727 0.272 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.727 0.273 0.000
H01 Other inflammation of eyelid
0.727 0.273 0.000
Z85.9 Personal history of malignant neoplasm, unspecified
0.727 0.273 0.000
W50-W64 Exposure to animate mechanical forces
0.727 0.273 0.000
G90-G99 Other disorders of the nervous system
0.726 0.273 0.000
X20-X29 Contact with venomous animals and plants
0.726 0.274 0.000
H33.1 Retinoschisis and retinal cysts
0.725 0.275 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.725 0.275 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.724 0.276 0.000
M20 Acquired deformities of fingers and toes
0.723 0.277 0.000
Z86.5 Personal history of other mental and behavioural disorders
0.722 0.278 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.722 0.278 0.000
M84.1 Nonunion of fracture [pseudarthrosis]
0.721 0.279 0.000
H50.0 Convergent concomitant strabismus
0.721 0.279 0.000
A41 Other septicaemia
0.720 0.280 0.000
R63 Symptoms and signs concerning food and fluid intake
0.720 0.280 0.000
T85.4 Mechanical complication of breast prosthesis and implant
0.720 0.280 0.000
T79-T79 Certain early complications of trauma
0.719 0.281 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.717 0.283 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.717 0.283 0.000
Z96.8 Presence of other specified functional implants
0.717 0.283 0.000
M60-M63 Disorders of muscles
0.717 0.283 0.000
Z84 Family history of other conditions
0.716 0.283 0.000
R65 Systemic Inflammatory Response Syndrome [SIRS]
0.716 0.283 0.000
R62 Lack of expected normal physiological development
0.716 0.283 0.000
R64 Cachexia
0.716 0.283 0.000
T33-T35 Frostbite
0.715 0.285 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.715 0.285 0.000
T00-T07 Injuries involving multiple body regions
0.715 0.285 0.000
H51 Other disorders of binocular movement
0.714 0.285 0.000
Z85.0 Personal history of malignant neoplasm of digestive organs
0.714 0.286 0.000
Z96.9 Presence of functional implant, unspecified
0.714 0.286 0.000
Z96.5 Presence of tooth-root and mandibular implants
0.714 0.286 0.000
Z96.4 Presence of endocrine implants
0.714 0.286 0.000
Z96.3 Presence of artificial larynx
0.714 0.286 0.000
Z96.2 Presence of otological and audiological implants
0.714 0.286 0.000
S70 Superficial injury of hip and thigh
0.714 0.286 0.000
K65-K67 Diseases of peritoneum
0.713 0.287 0.000
R50.2 Drug-induced fever
0.713 0.287 0.000
R50.1 Persistent fever
0.713 0.287 0.000
T84.3 Mechanical complication of other bone devices, implants and grafts
0.712 0.288 0.000
R56 Convulsions, not elsewhere classified
0.712 0.288 0.000
D02 Carcinoma in situ of middle ear and respiratory system
0.712 0.288 0.000
D01 Carcinoma in situ of other and unspecified digestive organs
0.712 0.288 0.000
D00 Carcinoma in situ of oral cavity, oesophagus and stomach
0.712 0.288 0.000
C79.7 Secondary malignant neoplasm of adrenal gland
0.712 0.288 0.000
M71 Other bursopathies
0.711 0.289 0.000
T86 Failure and rejection of transplanted organs and tissues
0.711 0.289 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.711 0.289 0.000
M33 Dermatopolymyositis
0.711 0.289 0.000
M32 Systemic lupus erythematosus
0.711 0.289 0.000
M30 Polyarteritis nodosa and related conditions
0.711 0.289 0.000
H31 Other disorders of choroid
0.711 0.289 0.000
G20-G26 Extrapyramidal and movement disorders
0.710 0.290 0.000
T87 Complications peculiar to reattachment and amputation
0.710 0.290 0.000
R93 Abnormal findings on diagnostic imaging of other body structures
0.710 0.290 0.000
R50.8 Other specified fever
0.709 0.291 0.000
R86 Abnormal findings in specimens from male genital organs
0.709 0.291 0.000
S80 Superficial injury of lower leg
0.708 0.292 0.000
M25.0 Haemarthrosis
0.708 0.292 0.000
C43.8 Overlapping malignant melanoma of skin
0.707 0.292 0.000
C43.4 Malignant melanoma of scalp and neck
0.707 0.292 0.000
C43.2 Malignant melanoma of ear and external auricular canal
0.707 0.292 0.000
C43.1 Malignant melanoma of eyelid, including canthus
0.707 0.292 0.000
C43.0 Malignant melanoma of lip
0.707 0.292 0.000
C39 Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs
0.707 0.293 0.000
C38 Malignant neoplasm of heart, mediastinum and pleura
0.707 0.293 0.000
C31 Malignant neoplasm of accessory sinuses
0.707 0.293 0.000
C30 Malignant neoplasm of nasal cavity and middle ear
0.707 0.293 0.000
C37 Malignant neoplasm of thymus
0.707 0.293 0.000
C33 Malignant neoplasm of trachea
0.707 0.293 0.000
M79.1 Myalgia
0.707 0.293 0.000
M72.0 Palmar fascial fibromatosis [Dupuytren]
0.707 0.293 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.706 0.294 0.000
C44.6 Skin of upper limb, including shoulder
0.706 0.294 0.000
Y35-Y36 Legal intervention and operations of war
0.705 0.295 0.000
Y10-Y34 Event of undetermined intent
0.705 0.295 0.000
Y00-Y09 Assault
0.705 0.295 0.000
X85-X99 Assault
0.705 0.295 0.000
X50-X57 Overexertion, travel and privation
0.705 0.295 0.000
X30-X39 Exposure to forces of nature
0.705 0.295 0.000
X10-X19 Contact with heat and hot substances
0.705 0.295 0.000
X00-X09 Exposure to smoke, fire and flames
0.705 0.295 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.705 0.295 0.000
W75-W84 Other accidental threats to breathing
0.705 0.295 0.000
W65-W74 Accidental drowning and submersion
0.705 0.295 0.000
V98-V99 Other and unspecified transport accidents
0.705 0.295 0.000
V95-V97 Air and space transport accidents
0.705 0.295 0.000
V90-V94 Water transport accidents
0.705 0.295 0.000
V80-V89 Other land transport accidents
0.705 0.295 0.000
V70-V79 Bus occupant injured in transport accident
0.705 0.295 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.705 0.295 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.705 0.295 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.705 0.295 0.000
V01-V09 Pedestrian injured in transport accident
0.705 0.295 0.000
S10-S19 Injuries to the neck
0.705 0.295 0.000
R84 Abnormal findings in specimens from respiratory organs and thorax
0.705 0.295 0.000
F30-F39 Mood [affective] disorders
0.704 0.296 0.000
H46 Optic neuritis
0.704 0.296 0.000
H52.7 Disorder of refraction, unspecified
0.703 0.297 0.000
H52.6 Other disorders of refraction
0.703 0.297 0.000
H52.5 Disorders of accommodation
0.703 0.297 0.000
H52.4 Presbyopia
0.703 0.297 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.703 0.297 0.000
H28 Cataract and other disorders of lens in diseases classified elsewhere
0.703 0.297 0.000
K91 Postprocedural disorders of digestive system, not elsewhere classified
0.703 0.297 0.000
C85.1 B-cell lymphoma, unspecified
0.703 0.297 0.000
C44.0 Skin of lip
0.702 0.297 0.000
K66 Other disorders of peritoneum
0.702 0.298 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.702 0.298 0.000
M79.2 Neuralgia and neuritis, unspecified
0.702 0.298 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.702 0.298 0.000
S82 Fracture of lower leg, including ankle
0.701 0.299 0.000
M34 Systemic sclerosis
0.700 0.299 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.700 0.300 0.000
J84.9 Interstitial pulmonary disease, unspecified
0.700 0.300 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.700 0.300 0.000
C34.0 Main bronchus
0.700 0.300 0.000
S72 Fracture of femur
0.700 0.300 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.700 0.300 0.000
C34.8 Overlapping lesion of bronchus and lung
0.699 0.301 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.699 0.301 0.000
R61.0 Localised hyperhidrosis
0.699 0.301 0.000
Y91 Evidence of alcohol involvement determined by level of intoxication
0.698 0.301 0.000
H25.2 Senile cataract, morgagnian type
0.698 0.302 0.000
M65.9 Synovitis and tenosynovitis, unspecified
0.698 0.302 0.000
M75.5 Bursitis of shoulder
0.696 0.304 0.000
H43 Disorders of vitreous body
0.696 0.304 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.695 0.304 0.000
D04.5 Skin of trunk
0.695 0.305 0.000
Z94 Transplanted organ and tissue status
0.695 0.305 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.695 0.305 0.000
H30 Chorioretinal inflammation
0.695 0.305 0.000
D41 Neoplasm of uncertain or unknown behaviour of urinary organs
0.695 0.305 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.694 0.306 0.000
J22 Unspecified acute lower respiratory infection
0.693 0.307 0.000
M13.90 Arthritis, unspecified (Multiple sites)
0.693 0.307 0.000
R59.9 Enlarged lymph nodes, unspecified
0.693 0.307 0.000
M25.55 Pain in joint (Pelvic region and thigh)
0.692 0.308 0.000
K66.0 Peritoneal adhesions
0.692 0.308 0.000
R89 Abnormal findings in specimens from other organs, systems and tissues
0.692 0.308 0.000
R83 Abnormal findings in cerebrospinal fluid
0.692 0.308 0.000
M25.2 Flail joint
0.691 0.308 0.000
M25.1 Fistula of joint
0.691 0.308 0.000
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.690 0.310 0.000
B35-B49 Mycoses
0.690 0.310 0.000
Z92.6 Personal history of chemotherapy for neoplastic disease
0.690 0.310 0.000
D37.0 Lip, oral cavity and pharynx
0.689 0.311 0.000
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts
0.689 0.311 0.000
H58 Other disorders of eye and adnexa in diseases classified elsewhere
0.689 0.311 0.000
D05.7 Other carcinoma in situ of breast
0.688 0.312 0.000
D03 Melanoma in situ
0.688 0.312 0.000
D07.1 Vulva
0.687 0.313 0.000
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.687 0.313 0.000
C17 Malignant neoplasm of small intestine
0.687 0.313 0.000
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites
0.686 0.314 0.000
C76 Malignant neoplasm of other and ill-defined sites
0.686 0.314 0.000
H33.5 Other retinal detachments
0.685 0.315 0.000
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
0.685 0.315 0.000
M79.6 Pain in limb
0.685 0.315 0.000
Y90 Evidence of alcohol involvement determined by blood alcohol level
0.685 0.315 0.000
Y98 Lifestyle-related condition
0.685 0.315 0.000
Y97 Environmental-pollution-related condition
0.685 0.315 0.000
Y96 Work-related condition
0.685 0.315 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.683 0.317 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.683 0.317 0.000
M84.0 Malunion of fracture
0.682 0.318 0.000
C25 Malignant neoplasm of pancreas
0.682 0.318 0.000
K00-K14 Diseases of oral cavity, salivary glands and jaws
0.680 0.320 0.000
Z91.5 Personal history of self-harm
0.680 0.320 0.000
G83 Other paralytic syndromes
0.680 0.320 0.000
H27 Other disorders of lens
0.679 0.321 0.000
Z85.1 Personal history of malignant neoplasm of trachea, bronchus and lung
0.678 0.322 0.000
R90 Abnormal findings on diagnostic imaging of central nervous system
0.678 0.322 0.000
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.677 0.323 0.000
C95 Leukaemia of unspecified cell type
0.677 0.323 0.000
C94 Other leukaemias of specified cell type
0.677 0.323 0.000
C93 Monocytic leukaemia
0.677 0.323 0.000
C86 Other specified types of T/NK-cell lymphoma
0.677 0.323 0.000
C84 Peripheral and cutaneous T-cell lymphomas
0.677 0.323 0.000
Z90 Acquired absence of organs, not elsewhere classified
0.677 0.323 0.000
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level
0.676 0.323 0.000
Z57.3 Occupational exposure to other air contaminants
0.676 0.324 0.000
Z83.3 Family history of diabetes mellitus
0.676 0.324 0.000
M79.7 Fibromyalgia
0.676 0.324 0.000
S91 Open wound of ankle and foot
0.676 0.324 0.000
D05.0 Lobular carcinoma in situ
0.675 0.325 0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases
0.675 0.325 0.000
H50.8 Other specified strabismus
0.675 0.325 0.000
H50.6 Mechanical strabismus
0.675 0.325 0.000
H50.5 Heterophoria
0.675 0.325 0.000
H50.4 Other and unspecified heterotropia
0.675 0.325 0.000
H50.3 Intermittent heterotropia
0.675 0.325 0.000
H50.2 Vertical strabismus
0.675 0.325 0.000
C60-C63 Malignant neoplasms of male genital organs
0.675 0.325 0.000
K91.8 Other postprocedural disorders of digestive system, not elsewhere classified
0.674 0.326 0.000
R22.7 Localised swelling, mass and lump, multiple sites
0.674 0.326 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.674 0.326 0.000
H57.8 Other specified disorders of eye and adnexa
0.673 0.327 0.000
Z63.0 Problems in relationship with spouse or partner
0.673 0.327 0.000
W00-W19 Falls
0.672 0.328 0.000
M24 Other specific joint derangements
0.672 0.328 0.000
T85.3 Mechanical complication of other ocular prosthetic devices, imnplants and grafts
0.670 0.330 0.000
T85.1 Mechanical complication of implanted electronic stimulator of nervous system
0.670 0.330 0.000
T85.0 Mechanical complication of ventricular intracranial (communicating) shunt
0.670 0.330 0.000
H54 Blindness and low vision
0.670 0.330 0.000
Z57.2 Occupational exposure to dust
0.670 0.330 0.000
C79.0 Secondary malignant neoplasm of kidney and renal pelvis
0.670 0.330 0.000
R93.0 Abnormal findings on diagnostic imaging of skull and head, not elsewhere classified
0.670 0.330 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.668 0.332 0.000
R87.9 Unspecified abnormal finding
0.668 0.332 0.000
R87.8 Other abnormal findings
0.668 0.332 0.000
R87.7 Abnormal histological findings
0.668 0.332 0.000
R87.5 Abnormal microbiological findings
0.668 0.332 0.000
R87.4 Abnormal immunological findings
0.668 0.332 0.000
R87.3 Abnormal level of substances chiefly nonmedicinal as to source
0.668 0.332 0.000
R87.2 Abnormal level of other drugs, medicaments and biological substances
0.668 0.332 0.000
R87.1 Abnormal level of hormones
0.668 0.332 0.000
R87.0 Abnormal level of enzymes
0.668 0.332 0.000
M80 Osteoporosis with pathological fracture
0.667 0.333 0.000
Z83.4 Family history of other endocrine, nutritional and metabolic diseases
0.667 0.333 0.000
C43.9 Malignant melanoma of skin, unspecified
0.665 0.334 0.000
Z63.4 Disappearance and death of family member
0.665 0.335 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.665 0.335 0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee
0.664 0.335 0.000
S20-S29 Injuries to the thorax
0.664 0.335 0.000
D45 Polycythaemia vera
0.664 0.336 0.000
Z93.8 Other artificial opening status
0.663 0.337 0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.663 0.337 0.000
C54.1 Endometrium
0.663 0.337 0.000
T98 Sequelae of other and unspecified effects of external causes
0.663 0.337 0.000
S82.3 Fracture of lower end of tibia
0.663 0.337 0.000
M95 Other acquired deformities of musculoskeletal system and connective tissue
0.662 0.338 0.000
T85.6 Mechanical complication of other specified internal prosthetic devices, implants and grafts
0.661 0.339 0.000
M35.9 Systemic involvement of connective tissue, unspecified
0.660 0.339 0.000
M35.8 Other specified systemic involvement of connective tissue
0.660 0.339 0.000
M35.7 Hypermobility syndrome
0.660 0.339 0.000
M35.6 Relapsing panniculitis [Weber-Christian]
0.660 0.339 0.000
M35.5 Multifocal fibrosclerosis
0.660 0.339 0.000
M35.4 Diffuse (eosinophilic) fasciitis
0.660 0.339 0.000
M35.2 Behcet's disease
0.660 0.339 0.000
M35.1 Other overlap syndromes
0.660 0.339 0.000
B95-B98 Bacterial, viral and other infectious agents
0.659 0.341 0.000
M82 Osteoporosis in diseases classified elsewhere
0.659 0.341 0.000
T95 Sequelae of burns, corrosions and frostbite
0.658 0.342 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.658 0.342 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.658 0.342 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.658 0.342 0.000
Y83.4 Other reconstructive surgery
0.658 0.342 0.000
C77.8 Lymph nodes of multiple regions
0.657 0.343 0.000
M25.84 Other specified joint disorders (Hand)
0.656 0.343 0.000
M87 Osteonecrosis
0.656 0.344 0.000
M25.57 Pain in joint (Ankle and foot)
0.656 0.344 0.000
T92.3 Sequelae of dislocation, sprain and strain of upper limb
0.655 0.345 0.000
F33 Recurrent depressive disorder
0.654 0.346 0.000
Z85.7 Personal history of other malignant neoplasms of lymphoid, haematopoietic and related tissues
0.653 0.347 0.000
M85 Other disorders of bone density and structure
0.652 0.348 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.652 0.348 0.000
M14 Arthropathies in other diseases classified elsewhere
0.652 0.348 0.000
M12 Other specific arthropathies
0.652 0.348 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.652 0.348 0.000
M08 Juvenile arthritis
0.652 0.348 0.000
Z80 Family history of malignant neoplasm
0.651 0.349 0.000
H03 Disorders of eyelid in diseases classified elsewhere
0.651 0.349 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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