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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs117759274
log Bayes Factor = 14.7453
Chromosome 12   position 23,131,855  (GRCh37) Explore rs117759274 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
E10-E14 Diabetes mellitus
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
0.999 0.001 0.000
Chapter IX Diseases of the circulatory system
0.998 0.002 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.997 0.003 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.996 0.004 0.000
E10.9 Without complications
0.995 0.005 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.993 0.007 0.000
I10-I15 Hypertensive diseases
0.990 0.010 0.000
Chapter VI Diseases of the nervous system
0.989 0.011 0.000
I30-I52 Other forms of heart disease
0.989 0.011 0.000
I50 Heart failure
0.983 0.017 0.000
I50.0 Congestive heart failure
0.982 0.018 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.975 0.025 0.000
E65-E68 Obesity and other hyperalimentation
0.974 0.026 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.974 0.026 0.000
Chapter XX External causes of morbidity and mortality
0.974 0.026 0.000
G40-G47 Episodic and paroxysmal disorders
0.967 0.033 0.000
E11 Non-insulin-dependent diabetes mellitus
0.965 0.035 0.000
I35 Nonrheumatic aortic valve disorders
0.959 0.041 0.000
E66 Obesity
0.956 0.044 0.000
I12 Hypertensive renal disease
0.954 0.046 0.000
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts
0.954 0.046 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.953 0.047 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.952 0.048 0.000
E14 Unspecified diabetes mellitus
0.950 0.050 0.000
E66.9 Obesity, unspecified
0.949 0.051 0.000
G40 Epilepsy
0.938 0.062 0.000
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts
0.936 0.064 0.000
I10 Essential (primary) hypertension
0.934 0.066 0.000
S80-S89 Injuries to the knee and lower leg
0.926 0.074 0.000
I12.0 Hypertensive renal disease with renal failure
0.925 0.075 0.000
I35.0 Aortic (valve) stenosis
0.924 0.076 0.000
O60-O75 Complications of labour and delivery
0.916 0.084 0.000
S60-S69 Injuries to the wrist and hand
0.915 0.085 0.000
T84.0 Mechanical complication of internal joint prosthesis
0.914 0.086 0.000
S40-S49 Injuries to the shoulder and upper arm
0.907 0.093 0.000
E20-E35 Disorders of other endocrine glands
0.904 0.096 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.904 0.096 0.000
E14.9 Without complications
0.899 0.101 0.000
T39.1 4-Aminophenol derivatives
0.890 0.110 0.000
Chapter V Mental and behavioural disorders
0.890 0.110 0.000
O68 Labour and delivery complicated by foetal stress [distress]
0.877 0.123 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.877 0.123 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.872 0.128 0.000
E70-E90 Metabolic disorders
0.871 0.129 0.000
I38 Endocarditis, valve unspecified
0.858 0.142 0.000
O32 Maternal care for known or suspected malpresentation of foetus
0.851 0.149 0.000
T39.0 Salicylates
0.850 0.150 0.000
Chapter VIII Diseases of the ear and mastoid process
0.849 0.151 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.849 0.151 0.000
E10.1 With ketoacidosis
0.848 0.152 0.000
O68.0 Labour and delivery complicated by foetal heart rate anomaly
0.848 0.152 0.000
S90-S99 Injuries to the ankle and foot
0.842 0.158 0.000
T66-T78 Other and unspecified effects of external causes
0.840 0.160 0.000
E10.4 With neurological complications
0.838 0.162 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.838 0.162 0.000
E50-E64 Other nutritional deficiencies
0.837 0.163 0.000
E11.9 Without complications
0.837 0.163 0.000
S10-S19 Injuries to the neck
0.831 0.169 0.000
S70-S79 Injuries to the hip and thigh
0.829 0.171 0.000
G40.6 Grand mal seizures, unspecified (with or without petit mal)
0.826 0.174 0.000
T84.1 Mechanical complication of internal fixation device of bones of limb
0.825 0.175 0.000
O30 Multiple gestation
0.823 0.177 0.000
E00-E07 Disorders of thyroid gland
0.823 0.177 0.000
T82.9 Unspecified complication of cardiac and vascular prosthetic device, implant and graft
0.821 0.179 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.821 0.179 0.000
E11.3 With ophthalmic complications
0.818 0.182 0.000
S00-S09 Injuries to the head
0.817 0.183 0.000
V10-V19 Pedal cyclist injured in transport accident
0.816 0.184 0.000
E10.3 With ophthalmic complications
0.813 0.187 0.000
S62 Fracture at wrist and hand level
0.810 0.190 0.000
G40.9 Epilepsy, unspecified
0.809 0.191 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.803 0.197 0.000
Chapter XXI Factors influencing health status and contact with health services
0.802 0.198 0.000
W00-W19 Falls
0.802 0.198 0.000
G40.2 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
0.802 0.198 0.000
E11.1 With ketoacidosis
0.799 0.201 0.000
O46 Antepartum haemorrhage, not elsewhere classified
0.795 0.205 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.794 0.206 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.794 0.206 0.000
T84.3 Mechanical complication of other bone devices, implants and grafts
0.792 0.208 0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee
0.792 0.208 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.791 0.209 0.000
G62 Other polyneuropathies
0.789 0.211 0.000
T82.2 Mechanical complication of coronary artery bypass and valve grafts
0.787 0.213 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.787 0.213 0.000
O00-O08 Pregnancy with abortive outcome
0.787 0.213 0.000
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status
0.786 0.214 0.000
I33 Acute and subacute endocarditis
0.785 0.215 0.000
E40-E46 Malnutrition
0.784 0.216 0.000
G45 Transient cerebral ischaemic attacks and related syndromes
0.783 0.217 0.000
Chapter I Certain infectious and parasitic diseases
0.783 0.217 0.000
F30-F39 Mood [affective] disorders
0.782 0.218 0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.782 0.218 0.000
T86 Failure and rejection of transplanted organs and tissues
0.780 0.220 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.780 0.220 0.000
Z88.8 Personal history of allergy to other drugs, medicaments and biological substances
0.780 0.220 0.000
S64 Injury of nerves at wrist and hand level
0.778 0.222 0.000
S50-S59 Injuries to the elbow and forearm
0.778 0.222 0.000
Z88 Personal history of allergy to drugs, medicaments and biologocal substances
0.777 0.223 0.000
O36 Maternal care for other known or suspected foetal problems
0.774 0.226 0.000
T84.6 Infection and inflammatory reaction due to internal fixation device [any site]
0.772 0.228 0.000
S20-S29 Injuries to the thorax
0.771 0.229 0.000
G44 Other headache syndromes
0.769 0.231 0.000
I35.9 Aortic valve disorder, unspecified
0.768 0.232 0.000
E03 Other hypothyroidism
0.767 0.233 0.000
I60-I69 Cerebrovascular diseases
0.767 0.233 0.000
S09 Other and unspecified injuries of head
0.767 0.233 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.767 0.233 0.000
O85-O92 Complications predominantly related to the puerperium
0.764 0.235 0.000
G90-G99 Other disorders of the nervous system
0.764 0.235 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.764 0.236 0.000
E11.5 With peripheral circulatory complications
0.763 0.237 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.762 0.238 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.762 0.238 0.000
E28 Ovarian dysfunction
0.757 0.243 0.000
E14.3 With ophthalmic complications
0.756 0.244 0.000
T43.0 Tricyclic and tetracyclic antidepressants
0.755 0.245 0.000
I15 Secondary hypertension
0.754 0.245 0.000
T79-T79 Certain early complications of trauma
0.754 0.246 0.000
I30 Acute pericarditis
0.753 0.247 0.000
S42 Fracture of shoulder and upper arm
0.751 0.249 0.000
I35.2 Aortic (valve) stenosis with insufficiency
0.750 0.250 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.750 0.250 0.000
H80-H83 Diseases of inner ear
0.750 0.250 0.000
E11.4 With neurological complications
0.748 0.252 0.000
S81 Open wound of lower leg
0.748 0.252 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.747 0.252 0.000
S49 Other and unspecified injuries of shoulder and upper arm
0.747 0.253 0.000
E23 Hypofunction and other disorders of pituitary gland
0.746 0.254 0.000
E11.6 With other specified complications
0.746 0.254 0.000
O48 Prolonged pregnancy
0.746 0.254 0.000
G41 Status epilepticus
0.745 0.255 0.000
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
0.743 0.257 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.743 0.257 0.000
O40 Polyhydramnios
0.740 0.260 0.000
O32.1 Maternal care for breech presentation
0.739 0.261 0.000
T92 Sequelae of injuries of upper limb
0.738 0.262 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.737 0.263 0.000
G40.3 Generalised idiopathic epilepsy and epileptic syndromes
0.736 0.264 0.000
S82 Fracture of lower leg, including ankle
0.736 0.264 0.000
G43 Migraine
0.735 0.265 0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis
0.734 0.266 0.000
O72 Postpartum haemorrhage
0.734 0.266 0.000
T84.2 Mechanical complication of internal fixation device of other bones
0.734 0.266 0.000
I42 Cardiomyopathy
0.733 0.267 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.731 0.269 0.000
S09.9 Unspecified injury of head
0.731 0.269 0.000
O30.0 Twin pregnancy
0.731 0.269 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.730 0.269 0.000
I11 Hypertensive heart disease
0.730 0.270 0.000
T84.4 Mechanical complication of other internal orthopaedic devices, imnplants and grafts
0.728 0.271 0.000
E03.9 Hypothyroidism, unspecified
0.728 0.272 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.726 0.274 0.000
E53 Deficiency of other B group vitamins
0.725 0.275 0.000
I67 Other cerebrovascular diseases
0.725 0.275 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.725 0.275 0.000
I12.9 Hypertensive renal disease without renal failure
0.723 0.277 0.000
R30-R39 Symptoms and signs involving the urinary system
0.723 0.277 0.000
E83 Disorders of mineral metabolism
0.723 0.277 0.000
G62.9 Polyneuropathy, unspecified
0.722 0.278 0.000
S40 Superficial injury of shoulder and upper arm
0.721 0.279 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.721 0.279 0.000
V20-V29 Motorcycle rider injured in transport accident
0.718 0.282 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
E13 Other specified diabetes mellitus
0.717 0.283 0.000
E12 Malnutrition-related diabetes mellitus
0.717 0.283 0.000
W20-W49 Exposure to inanimate mechanical forces
0.717 0.283 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.716 0.283 0.000
E10.8 With unspecified complications
0.716 0.284 0.000
E10.7 With multiple complications
0.716 0.284 0.000
E10.6 With other specified complications
0.716 0.284 0.000
E10.5 With peripheral circulatory complications
0.716 0.284 0.000
E10.2 With renal complications
0.716 0.284 0.000
E10.0 With coma
0.716 0.284 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.716 0.284 0.000
S89 Other and unspecified injuries of lower leg
0.716 0.284 0.000
I00-I02 Acute rheumatic fever
0.715 0.285 0.000
T87 Complications peculiar to reattachment and amputation
0.715 0.285 0.000
R94 Abnormal results of function studies
0.715 0.285 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.714 0.286 0.000
Z86.4 Personal history of psychoactive substance abuse
0.714 0.286 0.000
T84.9 Unspecified complication of internal orthopaedic prosthetic device, implant and graft
0.712 0.288 0.000
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts
0.712 0.288 0.000
S62.6 Fracture of other finger
0.712 0.288 0.000
I13 Hypertensive heart and renal disease
0.710 0.290 0.000
T82.1 Mechanical complication of cardiac electronic device
0.710 0.290 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.709 0.291 0.000
I52 Other heart disorders in diseases classified elsewhere
0.709 0.291 0.000
I48 Atrial fibrillation and flutter
0.709 0.291 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.709 0.291 0.000
I41 Myocarditis in diseases classified elsewhere
0.709 0.291 0.000
I40 Acute myocarditis
0.709 0.291 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.709 0.291 0.000
I37 Pulmonary valve disorders
0.709 0.291 0.000
I36 Nonrheumatic tricuspid valve disorders
0.709 0.291 0.000
I32 Pericarditis in diseases classified elsewhere
0.709 0.291 0.000
Z86 Personal history of certain other diseases
0.709 0.291 0.000
Y40 Systemic antibiotics
0.709 0.291 0.000
F60-F69 Disorders of adult personality and behaviour
0.709 0.291 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.708 0.292 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.708 0.292 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.708 0.292 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.707 0.293 0.000
Y42.5 Other oestrogens and progestogens
0.707 0.293 0.000
O35 Maternal care for known or suspected foetal abnormality and damage
0.706 0.294 0.000
R94.5 Abnormal results of liver function studies
0.704 0.296 0.000
V18 Pedal cyclist injured in noncollision transport accident
0.702 0.298 0.000
E22 Hyperfunction of pituitary gland
0.702 0.298 0.000
G30-G32 Other degenerative diseases of the nervous system
0.702 0.298 0.000
T78 Adverse effects, not elsewhere classified
0.702 0.298 0.000
O75 Other complications of labour and delivery, not elsewhere classified
0.701 0.299 0.000
W06 Fall involving bed
0.701 0.299 0.000
Z88.6 Personal history of allergy to analgesic agent
0.700 0.300 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.699 0.300 0.000
S83.2 Tear of meniscus, current
0.699 0.301 0.000
T82.5 Mechanical complication of other cardiac and vascular devices and implants
0.699 0.301 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.699 0.301 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.699 0.301 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.699 0.301 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.699 0.301 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.699 0.301 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.699 0.301 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.699 0.301 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.699 0.301 0.000
T36 Poisoning by systemic antibiotics
0.699 0.301 0.000
E67 Other hyperalimentation
0.698 0.302 0.000
E68 Sequelae of hyperalimentation
0.698 0.302 0.000
E65 Localised adiposity
0.698 0.302 0.000
T82.6 Infection and inflammatory reaction due to cardiac valve prosthesis
0.698 0.302 0.000
T82.4 Mechanical complication of vascular dialysis catheter
0.698 0.302 0.000
T82.3 Mechanical complication of other vascular grafts
0.698 0.302 0.000
T82.0 Mechanical complication of heart valve prosthesis
0.698 0.302 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.698 0.302 0.000
Y35-Y36 Legal intervention and operations of war
0.698 0.302 0.000
Y10-Y34 Event of undetermined intent
0.698 0.302 0.000
Y00-Y09 Assault
0.698 0.302 0.000
X85-X99 Assault
0.698 0.302 0.000
X50-X57 Overexertion, travel and privation
0.698 0.302 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.698 0.302 0.000
X30-X39 Exposure to forces of nature
0.698 0.302 0.000
X20-X29 Contact with venomous animals and plants
0.698 0.302 0.000
X10-X19 Contact with heat and hot substances
0.698 0.302 0.000
X00-X09 Exposure to smoke, fire and flames
0.698 0.302 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.698 0.302 0.000
W75-W84 Other accidental threats to breathing
0.698 0.302 0.000
W65-W74 Accidental drowning and submersion
0.698 0.302 0.000
W50-W64 Exposure to animate mechanical forces
0.698 0.302 0.000
V98-V99 Other and unspecified transport accidents
0.698 0.302 0.000
V95-V97 Air and space transport accidents
0.698 0.302 0.000
V90-V94 Water transport accidents
0.698 0.302 0.000
V80-V89 Other land transport accidents
0.698 0.302 0.000
V70-V79 Bus occupant injured in transport accident
0.698 0.302 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.698 0.302 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.698 0.302 0.000
V40-V49 Car occupant injured in transport accident
0.698 0.302 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.698 0.302 0.000
V01-V09 Pedestrian injured in transport accident
0.698 0.302 0.000
Chapter XXII Codes for special purposes
0.697 0.303 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.694 0.306 0.000
O32.4 Maternal care for high head at term
0.694 0.306 0.000
S60 Superficial injury of wrist and hand
0.694 0.306 0.000
T90 Sequelae of injuries of head
0.694 0.306 0.000
T18 Foreign body in alimentary tract
0.693 0.307 0.000
G46 Vascular syndromes of brain in cerebrovascular diseases
0.693 0.307 0.000
Z94 Transplanted organ and tissue status
0.693 0.307 0.000
E11.8 With unspecified complications
0.692 0.308 0.000
E11.7 With multiple complications
0.692 0.308 0.000
E11.0 With coma
0.692 0.308 0.000
S19 Other and unspecified injuries of neck
0.688 0.312 0.000
G70-G73 Diseases of myoneural junction and muscle
0.688 0.312 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.688 0.312 0.000
I35.8 Other aortic valve disorders
0.687 0.313 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.687 0.313 0.000
E27 Other disorders of adrenal gland
0.687 0.313 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.686 0.313 0.000
R35 Polyuria
0.686 0.314 0.000
E66.2 Extreme obesity with alveolar hypoventilation
0.685 0.315 0.000
E66.1 Drug-induced obesity
0.685 0.315 0.000
E66.0 Obesity due to excess calories
0.685 0.315 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.684 0.316 0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.683 0.316 0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.683 0.316 0.000
T39.4 Antirheumatics, not elsewhere classified
0.683 0.316 0.000
T39.2 Pyrazolone derivatives
0.683 0.316 0.000
O45 Premature separation of placenta [abruptio placentae]
0.683 0.317 0.000
O44 Placenta praevia
0.683 0.317 0.000
O43 Placental disorders
0.683 0.317 0.000
O41 Other disorders of amniotic fluid and membranes
0.683 0.317 0.000
O33 Maternal care for known or suspected disproportion
0.683 0.317 0.000
O31 Complications specific to multiple gestation
0.683 0.317 0.000
O46.9 Antepartum haemorrhage, unspecified
0.683 0.317 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.682 0.318 0.000
I31 Other diseases of pericardium
0.682 0.318 0.000
G95 Other diseases of spinal cord
0.681 0.319 0.000
E14.8 With unspecified complications
0.681 0.319 0.000
E14.7 With multiple complications
0.681 0.319 0.000
E14.6 With other specified complications
0.681 0.319 0.000
E14.5 With peripheral circulatory complications
0.681 0.319 0.000
E14.4 With neurological complications
0.681 0.319 0.000
E14.2 Withrenal complications
0.681 0.319 0.000
E14.1 With ketoacidosis
0.681 0.319 0.000
E14.0 With coma
0.681 0.319 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.680 0.320 0.000
Z91 Personal history of risk-factors, not elsewhere classified
0.680 0.320 0.000
O61 Failed induction of labour
0.679 0.321 0.000
S61 Open wound of wrist and hand
0.679 0.321 0.000
Y57 Other and unspecified drugs and medicaments
0.678 0.322 0.000
O68.1 Labour and delivery complicated by meconium in amniotic fluid
0.678 0.322 0.000
O80-O84 Delivery
0.677 0.323 0.000
I67.9 Cerebrovascular disease, unspecified
0.676 0.324 0.000
S46 Injury of muscle and tendon at shoulder and upper arm level
0.676 0.324 0.000
S69 Other and unspecified injuries of wrist and hand
0.675 0.325 0.000
X60-X84 Intentional self-harm
0.674 0.326 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.673 0.327 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.673 0.327 0.000
G40.8 Other epilepsy
0.672 0.328 0.000
G40.7 Petit mal, unspecified, without grand mal seizures
0.672 0.328 0.000
G40.5 Special epileptic syndromes
0.672 0.328 0.000
G40.4 Other generalised epilepsy and epileptic syndromes
0.672 0.328 0.000
G40.1 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
0.672 0.328 0.000
G40.0 Localisation-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localised onset
0.672 0.328 0.000
O66 Other obstructed labour
0.670 0.330 0.000
S67 Crushing injury of wrist and hand
0.669 0.330 0.000
F33 Recurrent depressive disorder
0.669 0.331 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
0.668 0.332 0.000
B95-B98 Bacterial, viral and other infectious agents
0.668 0.332 0.000
Z99 Dependence on enabling machines and devices, not elsewhere classified
0.668 0.332 0.000
S82.0 Fracture of patella
0.667 0.333 0.000
F29 Unspecified nonorganic psychosis
0.667 0.333 0.000
S91 Open wound of ankle and foot
0.666 0.334 0.000
S80 Superficial injury of lower leg
0.665 0.335 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.664 0.335 0.000
Z92 Personal history of medical treatment
0.664 0.336 0.000
S88 Traumatic amputation of lower leg
0.664 0.336 0.000
S87 Crushing injury of lower leg
0.664 0.336 0.000
S86 Injury of muscle and tendon at lower leg level
0.664 0.336 0.000
S85 Injury of blood vessels at lower leg level
0.664 0.336 0.000
S84 Injury of nerves at lower leg level
0.664 0.336 0.000
S92 Fracture of foot, except ankle
0.663 0.337 0.000
S72 Fracture of femur
0.662 0.338 0.000
G63.2 Diabetic polyneuropathy
0.661 0.339 0.000
G61 Inflammatory polyneuropathy
0.660 0.340 0.000
O69 Labour and delivery complicated by umbilical cord complications
0.660 0.340 0.000
Y95 Nosocomial condition
0.660 0.340 0.000
S66 Injury of muscle and tendon at wrist and hand level
0.658 0.342 0.000
O74 Complications of anaesthesia during labour and delivery
0.657 0.343 0.000
O73 Retained placenta and membranes, without haemorrhage
0.657 0.343 0.000
O71 Other obstetric trauma
0.657 0.343 0.000
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified
0.657 0.343 0.000
O65 Obstructed labour due to maternal pelvic abnormality
0.657 0.343 0.000
O60 Preterm delivery
0.657 0.343 0.000
O68.2 Labour and delivery complicated by foetal heart rate anomaly with meconium in amniotic fluid
0.657 0.343 0.000
Z70-Z76 Persons encountering health services in other circumstances
0.657 0.343 0.000
S65 Injury of blood vessels at wrist and hand level
0.656 0.344 0.000
S62.8 Fracture of other and unspecified parts of wrist and hand
0.656 0.344 0.000
S73 Dislocation, sprain and strain of joint and ligaments of hip
0.656 0.344 0.000
H90-H95 Other disorders of ear
0.655 0.344 0.000
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level
0.654 0.346 0.000
I77 Other disorders of arteries and arterioles
0.653 0.347 0.000
E28.2 Polycystic ovarian syndrome
0.652 0.348 0.000
H60-H62 Diseases of external ear
0.651 0.349 0.000
O63 Long labour
0.651 0.349 0.000
S48 Traumatic amputation of shoulder and upper arm
0.650 0.350 0.000
S45 Injury of blood vessels at shoulder and upper arm level
0.650 0.350 0.000
S44 Injury of nerves at shoulder and upper arm level
0.650 0.350 0.000
S41 Open wound of shoulder and upper arm
0.650 0.350 0.000
S47 Crushing injury of shoulder and upper arm
0.650 0.350 0.000
E88 Other metabolic disorders
0.650 0.350 0.000
F80-F89 Disorders of psychological development
0.649 0.351 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.648 0.351 0.000
E34 Other endocrine disorders
0.648 0.351 0.000
E32 Diseases of thymus
0.648 0.351 0.000
E31 Polyglandular dysfunction
0.648 0.351 0.000
E30 Disorders of puberty, not elsewhere classified
0.648 0.351 0.000
E29 Testicular dysfunction
0.648 0.351 0.000
E26 Hyperaldosteronism
0.648 0.351 0.000
E25 Adrenogenital disorders
0.648 0.351 0.000
E24 Cushing's syndrome
0.648 0.351 0.000
E20 Hypoparathyroidism
0.648 0.351 0.000
G60 Hereditary and idiopathic neuropathy
0.648 0.352 0.000
G64 Other disorders of peripheral nervous system
0.648 0.352 0.000
O68.8 Labour and delivery complicated by other evidence of foetal stress
0.648 0.352 0.000
O36.6 Maternal care for excessive foetal growth
0.647 0.353 0.000
S64.3 Injury of digital nerve of thumb
0.645 0.355 0.000
E53.8 Deficiency of other specified B group vitamins
0.645 0.355 0.000
S42.2 Fracture of upper end of humerus
0.644 0.356 0.000
T68 Hypothermia
0.643 0.357 0.000
I35.1 Aortic (valve) insufficiency
0.642 0.358 0.000
F31 Bipolar affective disorder
0.642 0.358 0.000
F34 Persistent mood [affective] disorders
0.642 0.358 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.641 0.359 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.641 0.359 0.000
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts
0.639 0.360 0.000
I33.0 Acute and subacute infective endocarditis
0.639 0.361 0.000
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle
0.638 0.362 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.638 0.362 0.000
F70-F79 Mental retardation
0.638 0.362 0.000
S99 Other and unspecified injuries of ankle and foot
0.638 0.362 0.000
Y44 Agents primarily affecting blood constituents
0.637 0.363 0.000
S22 Fracture of rib(s), sternum and thoracic spine
0.636 0.363 0.000
T93 Sequelae of injuries of lower limb
0.636 0.364 0.000
S62.60 Fracture of other finger (closed)
0.636 0.364 0.000
H80 Otosclerosis
0.635 0.365 0.000
T86.1 Kidney transplant failure and rejection
0.634 0.365 0.000
O24 Diabetes mellitus in pregnancy
0.634 0.366 0.000
E23.0 Hypopituitarism
0.633 0.367 0.000
S12 Fracture of neck
0.633 0.367 0.000
Y42.3 Insulin and oral hypoglycaemic [antidiabetic] drugs
0.632 0.368 0.000
E87.5 Hyperkalaemia
0.632 0.368 0.000
O02 Other abnormal products of conception
0.632 0.368 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.632 0.368 0.000
S49.9 Unspecified injury of shoulder and upper arm
0.631 0.368 0.000
O34 Maternal care for known or suspected abnormality of pelvic organs
0.631 0.369 0.000
Z83 Family history of other specific disorders
0.631 0.369 0.000
E46 Unspecified protein-energy malnutrition
0.629 0.371 0.000
S81.8 Open wound of other parts of lower leg
0.629 0.371 0.000
O68.3 Labour and delivery complicated by biochemical evidence of foetal stress
0.629 0.371 0.000
Y59 Other and unspecified vaccines and biological substances
0.629 0.371 0.000
Y58 Bacterial vaccines
0.629 0.371 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.629 0.371 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.629 0.371 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.629 0.371 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.629 0.371 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.629 0.371 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.629 0.371 0.000
Y48 Anaesthetics and therapeutic gases
0.629 0.371 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.629 0.371 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.629 0.371 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.629 0.371 0.000
L03 Cellulitis
0.629 0.371 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.628 0.372 0.000
Z92.1 Personal history of long-term (current) use of anticoagulants
0.628 0.372 0.000
W06.0 Home
0.628 0.372 0.000
G44.2 Tension-type headache
0.628 0.372 0.000
Y52 Agents primarily affecting the cardiovascular system
0.627 0.372 0.000
O36.9 Maternal care for foetal problem, unspecified
0.627 0.373 0.000
O62 Abnormalities of forces of labour
0.627 0.373 0.000
F99-F99 Unspecified mental disorder
0.626 0.374 0.000
T98 Sequelae of other and unspecified effects of external causes
0.625 0.375 0.000
T95 Sequelae of burns, corrosions and frostbite
0.625 0.375 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.625 0.375 0.000
T91 Sequelae of injuries of neck and trunk
0.625 0.375 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.625 0.375 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.625 0.375 0.000
E85 Amyloidosis
0.625 0.375 0.000
E84 Cystic fibrosis
0.625 0.375 0.000
E79 Disorders of purine and pyrimidine metabolism
0.625 0.375 0.000
E77 Disorders of glycoprotein metabolism
0.625 0.375 0.000
E76 Disorders of glycosaminoglycan metabolism
0.625 0.375 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.625 0.375 0.000
E74 Other disorders of carbohydrate metabolism
0.625 0.375 0.000
E73 Lactose intolerance
0.625 0.375 0.000
E72 Other disorders of amino-acid metabolism
0.625 0.375 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.625 0.375 0.000
E70 Disorders of aromatic amino-acid metabolism
0.625 0.375 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.625 0.375 0.000
E55 Vitamin D deficiency
0.623 0.376 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.623 0.377 0.000
O99.5 Diseases of the respiratory system complicating pregnancy, childbirth and the puerperium
0.623 0.377 0.000
O72.1 Other immediate postpartum haemorrhage
0.622 0.377 0.000
V18.0 Driver injured in nontraffic accident
0.621 0.379 0.000
O20 Haemorrhage in early pregnancy
0.620 0.379 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.619 0.381 0.000
S70 Superficial injury of hip and thigh
0.619 0.381 0.000
S82.00 Fracture of patella (closed)
0.618 0.382 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.617 0.383 0.000
A80-A89 Viral infections of the central nervous system
0.617 0.383 0.000
I73 Other peripheral vascular diseases
0.617 0.383 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.617 0.383 0.000
Q60-Q64 Congenital malformations of the urinary system
0.616 0.384 0.000
S64.4 Injury of digital nerve of other finger
0.616 0.384 0.000
B99-B99 Other infectious diseases
0.616 0.384 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.615 0.385 0.000
Z88.9 Personal history of allergy to unspecified drugs, medicaments and biological substances
0.614 0.386 0.000
E86 Volume depletion
0.613 0.387 0.000
S06 Intracranial injury
0.612 0.388 0.000
Y40.8 Other systemic antibiotics
0.612 0.388 0.000
R90 Abnormal findings on diagnostic imaging of central nervous system
0.612 0.388 0.000
Q00-Q07 Congenital malformations of the nervous system
0.611 0.389 0.000
O00 Ectopic pregnancy
0.611 0.389 0.000
S62.0 Fracture of navicular [scaphoid] bone of hand
0.610 0.390 0.000
O32.9 Maternal care for malpresentation of foetus, unspecified
0.610 0.390 0.000
O32.8 Maternal care for other malpresentation of foetus
0.610 0.390 0.000
O32.6 Maternal care for compound presentation
0.610 0.390 0.000
O32.5 Maternal care for multiple gestation with malpresentation of one foetus or more
0.610 0.390 0.000
O32.3 Maternal care for face, brow and chin presentation
0.610 0.390 0.000
O32.2 Maternal care for transverse and oblique lie
0.610 0.390 0.000
O32.0 Maternal care for unstable lie
0.610 0.390 0.000
E83.4 Disorders of magnesium metabolism
0.609 0.391 0.000
T92.3 Sequelae of dislocation, sprain and strain of upper limb
0.609 0.391 0.000
O98 Maternal infectious and parasitic diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
0.608 0.391 0.000
O97 Death from sequelae of direct obstetric causes
0.608 0.391 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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