TreeWAS – Variant ID: rs11944781

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability
# Top node	1.000	0.000
Chapter IX Diseases of the circulatory system	0.996	0.004
Chapter II Neoplasms	0.995	0.005
I30-I52 Other forms of heart disease	0.994	0.006
Chapter IV Endocrine, nutritional and metabolic diseases	0.994	0.006
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.989	0.011
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.986	0.014
C15-C26 Malignant neoplasms of digestive organs	0.984	0.016
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	0.982	0.018
I60-I69 Cerebrovascular diseases	0.982	0.018
D50-D53 Nutritional anaemias	0.980	0.020
D50 Iron deficiency anaemia	0.973	0.027
D50.8 Other iron deficiency anaemias	0.968	0.032
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour	0.965	0.035
I44 Atrioventricular and left bundle-branch block	0.963	0.037
I51 Complications and ill-defined descriptions of heart disease	0.946	0.054
C43-C44 Melanoma and other malignant neoplasms of skin	0.941	0.059
Chapter XX External causes of morbidity and mortality	0.937	0.063
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system	0.932	0.068
E10-E14 Diabetes mellitus	0.920	0.080
C44 Other malignant neoplasms of skin	0.918	0.082
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis	0.915	0.085
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.914	0.086
D37-D48 Neoplasms of uncertain or unknown behaviour	0.911	0.089
R41 Other symptoms and signs involving cognitive functions and awareness	0.908	0.092
I44.0 Atrioventricular block, first degree	0.906	0.094
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.903	0.097
I47 Paroxysmal tachycardia	0.900	0.100
T80-T88 Complications of surgical and medical care, not elsewhere classified	0.900	0.100
E00-E07 Disorders of thyroid gland	0.898	0.102
C20 Malignant neoplasm of rectum	0.892	0.108
M80-M85 Disorders of bone density and structure	0.892	0.108
I50 Heart failure	0.882	0.118
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts	0.878	0.122
I64 Stroke, not specified as haemorrhage or infarction	0.877	0.123
C45-C49 Malignant neoplasms of mesothelial and soft tissue	0.875	0.125
C51-C58 Malignant neoplasms of female genital organs	0.875	0.125
R30-R39 Symptoms and signs involving the urinary system	0.874	0.126
I63 Cerebral infarction	0.870	0.130
M81 Osteoporosis without pathological fracture	0.868	0.132
S20-S29 Injuries to the thorax	0.868	0.132
C71 Malignant neoplasm of brain	0.866	0.134
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.864	0.136
C16 Malignant neoplasm of stomach	0.863	0.137
C18 Malignant neoplasm of colon	0.862	0.138
E04 Other non-toxic goitre	0.857	0.143
T36-T50 Poisoning by drugs, medicaments and biological substances	0.857	0.143
R93 Abnormal findings on diagnostic imaging of other body structures	0.854	0.146
R47-R49 Symptoms and signs involving speech and voice	0.854	0.146
I51.7 Cardiomegaly	0.851	0.149
M81.9 Osteoporosis, unspecified	0.851	0.149
E10 Insulin-dependent diabetes mellitus	0.850	0.150
R41.0 Disorientation, unspecified	0.850	0.150
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts	0.846	0.154
E70-E90 Metabolic disorders	0.845	0.155
C44.6 Skin of upper limb, including shoulder	0.843	0.157
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue	0.831	0.169
I05-I09 Chronic rheumatic heart diseases	0.831	0.169
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.831	0.169
I69 Sequelae of cerebrovascular disease	0.830	0.170
I51.8 Other ill-defined heart diseases	0.829	0.171
R32 Unspecified urinary incontinence	0.825	0.175
T84.0 Mechanical complication of internal joint prosthesis	0.825	0.175
I47.1 Supraventricular tachycardia	0.824	0.176
C44.2 Skin of ear and external auricular canal	0.824	0.176
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.817	0.183
R42 Dizziness and giddiness	0.817	0.183
T66-T78 Other and unspecified effects of external causes	0.815	0.185
I44.7 Left bundle-branch block, unspecified	0.815	0.185
C17 Malignant neoplasm of small intestine	0.812	0.188
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.812	0.188
C49 Malignant neoplasm of other connective and soft tissue	0.811	0.189
E89.0 Postprocedural hypothyroidism	0.810	0.190
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.809	0.191
E20-E35 Disorders of other endocrine glands	0.806	0.194
I61 Intracerebral haemorrhage	0.805	0.195
I31 Other diseases of pericardium	0.804	0.196
S70-S79 Injuries to the hip and thigh	0.804	0.196
Q80-Q89 Other congenital malformations	0.800	0.200
C44.3 Skin of other and unspecified parts of face	0.798	0.202
I51.6 Cardiovascular disease, unspecified	0.796	0.203
S10-S19 Injuries to the neck	0.796	0.204
I67 Other cerebrovascular diseases	0.793	0.207
R93.1 Abnormal findings on diagnostic imaging of heart and coronary circulation	0.792	0.208
M81.99 Osteoporosis, unspecified (Site unspecified)	0.790	0.210
C22 Malignant neoplasm of liver and intrahepatic bile ducts	0.789	0.211
E50-E64 Other nutritional deficiencies	0.788	0.212
R40 Somnolence, stupor and coma	0.786	0.213
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.784	0.216
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue	0.783	0.217
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs	0.783	0.217
C24 Malignant neoplasm of other and unspecified parts of biliary tract	0.781	0.219
I63.3 Cerebral infarction due to thrombosis of cerebral arteries	0.781	0.219
Chapter VIII Diseases of the ear and mastoid process	0.780	0.220
I44.3 Other and unspecified atrioventricular block	0.779	0.221
I50.9 Heart failure, unspecified	0.778	0.222
E04.2 Non-toxic multinodular goitre	0.777	0.223
R94 Abnormal results of function studies	0.777	0.223
R22 Localised swelling, mass and lump of skin and subcutaneous tissue	0.773	0.227
R46 Symptoms and signs involving appearance and behaviour	0.772	0.228
S90-S99 Injuries to the ankle and foot	0.770	0.230
M81.90 Osteoporosis, unspecified (Multiple sites)	0.769	0.231
S20 Superficial injury of thorax	0.769	0.231
I60 Subarachnoid haemorrhage	0.768	0.232
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx	0.768	0.232
D39 Neoplasm of uncertain or unknown behaviour of female genital organs	0.766	0.234
R43 Disturbances of smell and taste	0.759	0.241
I46 Cardiac arrest	0.759	0.241
I35 Nonrheumatic aortic valve disorders	0.759	0.241
M05-M14 Inflammatory polyarthropathies	0.758	0.242
C16.0 Cardia	0.757	0.243
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.756	0.244
R50-R69 General symptoms and signs	0.754	0.246
C18.2 Ascending colon	0.753	0.247
I50.1 Left ventricular failure	0.752	0.248
X50-X57 Overexertion, travel and privation	0.750	0.250
I33 Acute and subacute endocarditis	0.750	0.250
C69 Malignant neoplasm of eye and adnexa	0.749	0.251
I44.1 Atrioventricular block, second degree	0.748	0.252
W00-W19 Falls	0.747	0.253
M40-M43 Deforming dorsopathies	0.746	0.254
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts	0.745	0.255
C44.7 Skin of lower limb, including hip	0.745	0.255
M91-M94 Chondropathies	0.744	0.256
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)	0.743	0.256
T20-T25 Burns and corrosions of external body surface, specified by site	0.742	0.258
E40-E46 Malnutrition	0.741	0.259
I08 Multiple valve diseases	0.740	0.260
I34 Nonrheumatic mitral valve disorders	0.739	0.261
D55-D59 Haemolytic anaemias	0.737	0.262
C18.7 Sigmoid colon	0.736	0.264
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs	0.735	0.265
T79-T79 Certain early complications of trauma	0.734	0.266
E65-E68 Obesity and other hyperalimentation	0.734	0.266
C44.4 Skin of scalp and neck	0.734	0.266
R23 Other skin changes	0.733	0.267
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.732	0.268
V80-V89 Other land transport accidents	0.732	0.268
C71.9 Brain, unspecified	0.732	0.268
C73-C75 Malignant neoplasms of thyroid and other endocrine glands	0.731	0.269
R94.5 Abnormal results of liver function studies	0.730	0.270
D52 Folate deficiency anaemia	0.730	0.270
D80-D89 Certain disorders involving the immune mechanism	0.730	0.270
Y52 Agents primarily affecting the cardiovascular system	0.730	0.270
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.729	0.271
E13 Other specified diabetes mellitus	0.727	0.273
M60-M63 Disorders of muscles	0.727	0.273
C44.0 Skin of lip	0.726	0.274
C49.0 Connective and soft tissue of head, face and neck	0.726	0.274
C54 Malignant neoplasm of corpus uteri	0.724	0.276
X20-X29 Contact with venomous animals and plants	0.722	0.277
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.722	0.278
T80 Complications following infusion, transfusion and therapeutic injection	0.722	0.278
S50-S59 Injuries to the elbow and forearm	0.721	0.279
I44.6 Other and unspecified fascicular block	0.720	0.280
Y44 Agents primarily affecting blood constituents	0.718	0.282
C97-C97 Malignant neoplasms of independent (primary) multiple sites	0.718	0.282
Chapter XVI Certain conditions originating in the perinatal period	0.717	0.283
Chapter VI Diseases of the nervous system	0.715	0.285
E04.9 Non-toxic goitre, unspecified	0.715	0.285
I00-I02 Acute rheumatic fever	0.714	0.286
C40-C41 Malignant neoplasms of bone and articular cartilage	0.714	0.286
C15 Malignant neoplasm of oesophagus	0.714	0.286
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system	0.713	0.287
I52 Other heart disorders in diseases classified elsewhere	0.712	0.287
I48 Atrial fibrillation and flutter	0.712	0.287
I43 Cardiomyopathy in diseases classified elsewhere	0.712	0.287
I41 Myocarditis in diseases classified elsewhere	0.712	0.287
I40 Acute myocarditis	0.712	0.287
I39 Endocarditis and heart valve disorders in diseases classified elsewhere	0.712	0.287
I37 Pulmonary valve disorders	0.712	0.287
I32 Pericarditis in diseases classified elsewhere	0.712	0.287
R22.1 Localised swelling, mass and lump, neck	0.712	0.288
R47 Speech disturbances, not elsewhere classified	0.711	0.289
R41.8 Other and unspecified symptoms and signs involving cognitive functions and awareness	0.710	0.290
I47.0 Reentry ventricular arrhythmia	0.709	0.291
C26 Malignant neoplasm of other and ill-defined digestive organs	0.709	0.291
Chapter XXII Codes for special purposes	0.708	0.291
X40-X49 Accidental poisoning by and exposure to noxious substances	0.707	0.293
T33-T35 Frostbite	0.707	0.293
T26-T28 Burns and corrosions confined to eye and internal organs	0.707	0.293
T00-T07 Injuries involving multiple body regions	0.707	0.293
Chapter XII Diseases of the skin and subcutaneous tissue	0.707	0.293
E27 Other disorders of adrenal gland	0.706	0.294
C18.6 Descending colon	0.706	0.294
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.706	0.294
C71.3 Parietal lobe	0.706	0.294
C56 Malignant neoplasm of ovary	0.706	0.294
T87 Complications peculiar to reattachment and amputation	0.705	0.295
C23 Malignant neoplasm of gallbladder	0.705	0.295
I36 Nonrheumatic tricuspid valve disorders	0.705	0.295
R95-R99 Ill-defined and unknown causes of mortality	0.704	0.296
E04.1 Non-toxic single thyroid nodule	0.704	0.296
M06 Other rheumatoid arthritis	0.704	0.296
I68 Cerebrovascular disorders in diseases classified elsewhere	0.704	0.296
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction	0.704	0.296
R30 Pain associated with micturition	0.704	0.296
T46 Poisoning by agents primarily affecting the cardiovascular system	0.703	0.297
R44 Other symptoms and signs involving general sensations and perceptions	0.703	0.297
D53 Other nutritional anaemias	0.702	0.297
R40.2 Coma, unspecified	0.702	0.298
D70-D77 Other diseases of blood and blood-forming organs	0.702	0.298
C21 Malignant neoplasm of anus and anal canal	0.701	0.299
X58-X59 Accidental exposure to other and unspecified factors	0.701	0.299
R93.3 Abnormal findings on diagnostic imaging of other parts of digestive tract	0.701	0.299
D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs	0.700	0.300
S20.8 Superficial injuries of other and unspecified parts of thorax	0.699	0.301
M80 Osteoporosis with pathological fracture	0.699	0.301
R49 Voice disturbances	0.698	0.302
D50.1 Sideropenic dysphagia	0.698	0.302
E07 Other disorders of thyroid	0.697	0.303
Y40 Systemic antibiotics	0.697	0.303
T31 Burns classified according to extent of body surface involved	0.696	0.304
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.695	0.305
D50.9 Iron deficiency anaemia, unspecified	0.694	0.306
R39 Other symptoms and signs involving the urinary system	0.693	0.307
T78 Adverse effects, not elsewhere classified	0.692	0.308
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure	0.692	0.308
E73 Lactose intolerance	0.692	0.308
E10.5 With peripheral circulatory complications	0.691	0.308
D47.2 Monoclonal gammopathy	0.691	0.309
I44.5 Left posterior fascicular block	0.690	0.309
I44.4 Left anterior fascicular block	0.690	0.309
C17.2 Ileum	0.690	0.310
I63.5 Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries	0.689	0.311
C71.2 Temporal lobe	0.689	0.311
W50-W64 Exposure to animate mechanical forces	0.688	0.311
C49.2 Connective and soft tissue of lower limb, including hip	0.687	0.312
S32 Fracture of lumbar spine and pelvis	0.687	0.313
R90 Abnormal findings on diagnostic imaging of central nervous system	0.686	0.314
Q38-Q45 Other congenital malformations of the digestive system	0.686	0.314
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.685	0.315
C51 Malignant neoplasm of vulva	0.685	0.315
C25 Malignant neoplasm of pancreas	0.685	0.315
C71.1 Frontal lobe	0.682	0.318
E10.2 With renal complications	0.682	0.318
I31.3 Pericardial effusion (noninflammatory)	0.681	0.319
E06 Thyroiditis	0.681	0.319
M81.95 Osteoporosis, unspecified (Pelvic region and thigh)	0.680	0.320
R52 Pain, not elsewhere classified	0.680	0.320
I45 Other conduction disorders	0.679	0.321
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.679	0.321
E14 Unspecified diabetes mellitus	0.679	0.321
I51.5 Myocardial degeneration	0.679	0.321
I51.4 Myocarditis, unspecified	0.679	0.321
I51.3 Intracardiac thrombosis, not elsewhere classified	0.679	0.321
I51.2 Rupture of papillary muscle, not elsewhere classified	0.679	0.321
I51.1 Rupture of chordae tendineae, not elsewhere classified	0.679	0.321
I51.0 Cardiac septal defect, acquired	0.679	0.321
E53 Deficiency of other B group vitamins	0.677	0.323
I62 Other nontraumatic intracranial haemorrhage	0.677	0.323
R93.7 Abnormal findings on diagnostic imaging of other parts of musculoskeletal system	0.676	0.324
D51 Vitamin B12 deficiency anaemia	0.675	0.325
R41.3 Other amnesia	0.675	0.325
W20-W49 Exposure to inanimate mechanical forces	0.675	0.325
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use	0.672	0.328
Y35-Y36 Legal intervention and operations of war	0.672	0.328
Y10-Y34 Event of undetermined intent	0.672	0.328
Y00-Y09 Assault	0.672	0.328
X85-X99 Assault	0.672	0.328
X30-X39 Exposure to forces of nature	0.672	0.328
X10-X19 Contact with heat and hot substances	0.672	0.328
X00-X09 Exposure to smoke, fire and flames	0.672	0.328
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure	0.672	0.328
W75-W84 Other accidental threats to breathing	0.672	0.328
W65-W74 Accidental drowning and submersion	0.672	0.328
V98-V99 Other and unspecified transport accidents	0.672	0.328
V95-V97 Air and space transport accidents	0.672	0.328
V90-V94 Water transport accidents	0.672	0.328
V70-V79 Bus occupant injured in transport accident	0.672	0.328
V60-V69 Occupant of heavy transport vehicle injured in transport accident	0.672	0.328
V50-V59 Occupant of pick-up truck or van injured in transport accident	0.672	0.328
V40-V49 Car occupant injured in transport accident	0.672	0.328
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident	0.672	0.328
V01-V09 Pedestrian injured in transport accident	0.672	0.328
I69.8 Sequelae of other and unspecified cerebrovascular diseases	0.672	0.328
Y60-Y69 Misadventures to patients during surgical and medical care	0.670	0.329
D00-D09 In situ neoplasms	0.670	0.330
I61.9 Intracerebral haemorrhage, unspecified	0.668	0.332
C72 Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system	0.668	0.332
C70 Malignant neoplasm of meninges	0.668	0.332
M84 Disorders of continuity of bone	0.668	0.332
E89.2 Postprocedural hypoparathyroidism	0.668	0.332
I67.1 Cerebral aneurysm, nonruptured	0.667	0.333
Q89 Other congenital malformations, not elsewhere classified	0.666	0.334
C16.9 Stomach, unspecified	0.664	0.336
T92 Sequelae of injuries of upper limb	0.664	0.336
R47.0 Dysphasia and aphasia	0.664	0.336
I63.2 Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries	0.664	0.336
M86-M90 Other osteopathies	0.662	0.338
D39.1 Ovary	0.662	0.338
I42 Cardiomyopathy	0.661	0.339
E12 Malnutrition-related diabetes mellitus	0.660	0.340
C44.9 Malignant neoplasm of skin, unspecified	0.658	0.342
C44.8 Overlapping lesion of skin	0.658	0.342
H65-H75 Diseases of middle ear and mastoid	0.658	0.342
E10.3 With ophthalmic complications	0.657	0.343
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts	0.657	0.343
E89.3 Postprocedural hypopituitarism	0.657	0.343
R92 Abnormal findings on diagnostic imaging of breast	0.656	0.344
M00-M03 Infectious arthropathies	0.655	0.344
R51 Headache	0.656	0.344
M65-M68 Disorders of synovium and tendon	0.655	0.345
S27 Injury of other and unspecified intrathoracic organs	0.655	0.345
R23.8 Other and unspecified skin changes	0.654	0.346
I69.1 Sequelae of intracerebral haemorrhage	0.654	0.346
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands	0.653	0.347
D42 Neoplasm of uncertain or unknown behaviour of meninges	0.653	0.347
D40 Neoplasm of uncertain or unknown behaviour of male genital organs	0.653	0.347
E10.9 Without complications	0.653	0.347
E10.1 With ketoacidosis	0.653	0.347
E23 Hypofunction and other disorders of pituitary gland	0.652	0.347
Q60-Q64 Congenital malformations of the urinary system	0.652	0.348
Q82 Other congenital malformations of skin	0.652	0.348
V20-V29 Motorcycle rider injured in transport accident	0.651	0.348
R41.1 Anterograde amnesia	0.651	0.349
S40-S49 Injuries to the shoulder and upper arm	0.651	0.349
E10.4 With neurological complications	0.650	0.349
R41.2 Retrograde amnesia	0.650	0.350
D68 Other coagulation defects	0.649	0.351
T82.1 Mechanical complication of cardiac electronic device	0.649	0.351
T43.5 Other and unspecified antipsychotics and neuroleptics	0.648	0.352
M81.98 Osteoporosis, unspecified (Other)	0.648	0.352
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.647	0.352
Q35-Q37 Cleft lip and cleft palate	0.647	0.352
Q30-Q34 Congenital malformations of the respiratory system	0.647	0.352
S29 Other and unspecified injuries of thorax	0.647	0.353
M85 Other disorders of bone density and structure	0.647	0.353
R93.4 Abnormal findings on diagnostic imaging of urinary organs	0.647	0.353
I47.9 Paroxysmal tachycardia, unspecified	0.645	0.354
I35.8 Other aortic valve disorders	0.644	0.356
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.644	0.356
E00 Congenital iodine-deficiency syndrome	0.644	0.356
E02 Subclinical iodine-deficiency hypothyroidism	0.644	0.356
S71 Open wound of hip and thigh	0.643	0.357
R35 Polyuria	0.642	0.358
I08.3 Combined disorders of mitral, aortic and tricuspid valves	0.642	0.358
I30 Acute pericarditis	0.641	0.358
D37.2 Small intestine	0.642	0.358
R52.2 Other chronic pain	0.641	0.359
M06.9 Rheumatoid arthritis, unspecified	0.640	0.360
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction	0.640	0.360
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis	0.640	0.360
M83 Adult osteomalacia	0.640	0.360
M82 Osteoporosis in diseases classified elsewhere	0.640	0.360
R22.0 Localised swelling, mass and lump, head	0.639	0.361
Y85-Y89 Sequelae of external causes of morbidity and mortality	0.638	0.362
R45 Symptoms and signs involving emotional state	0.638	0.362
Q00-Q07 Congenital malformations of the nervous system	0.637	0.362
D37.4 Colon	0.637	0.363
C18.4 Transverse colon	0.637	0.363
R93.5 Abnormal findings on diagnostic imaging of other abdominal regions, including retroperitoneum	0.636	0.364
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.636	0.364
C24.0 Extrahepatic bile duct	0.636	0.364
E11 Non-insulin-dependent diabetes mellitus	0.636	0.364
R46.4 Slowness and poor responsiveness	0.634	0.366
R80-R82 Abnormal findings on examination of urine, without diagnosis	0.633	0.367
D45 Polycythaemia vera	0.633	0.367
Y41 Other systemic anti-infectives and antiparasitics	0.633	0.367
M43 Other deforming dorsopathies	0.632	0.368
X60-X84 Intentional self-harm	0.632	0.368
Y84 Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure	0.631	0.369
I05 Rheumatic mitral valve diseases	0.630	0.370
T84.9 Unspecified complication of internal orthopaedic prosthetic device, implant and graft	0.629	0.370
T84.3 Mechanical complication of other bone devices, implants and grafts	0.629	0.370
R57 Shock, not elsewhere classified	0.629	0.371
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.629	0.371
I35.1 Aortic (valve) insufficiency	0.628	0.372
R39.1 Other difficulties with micturition	0.628	0.372
C48 Malignant neoplasm of retroperitoneum and peritoneum	0.627	0.373
C47 Malignant neoplasm of peripheral nerves and autonomic nervous system	0.627	0.373
C46 Kaposi's sarcoma	0.627	0.373
C57 Malignant neoplasm of other and unspecified female genital organs	0.627	0.373
C58 Malignant neoplasm of placenta	0.627	0.373
C52 Malignant neoplasm of vagina	0.627	0.373
R36 Urethral discharge	0.627	0.373
R34 Anuria and oliguria	0.627	0.373
I08.0 Disorders of both mitral and aortic valves	0.627	0.373
L20-L30 Dermatitis and eczema	0.627	0.373
R22.2 Localised swelling, mass and lump, trunk	0.627	0.373
I60.9 Subarachnoid haemorrhage, unspecified	0.625	0.375
I63.6 Cerebral infarction due to cerebral venous thrombosis, nonpyogenic	0.624	0.376
I63.4 Cerebral infarction due to embolism of cerebral arteries	0.624	0.376
I63.1 Cerebral infarction due to embolism of precerebral arteries	0.624	0.376
I63.0 Cerebral infarction due to thrombosis of precerebral arteries	0.624	0.376
D69 Purpura and other haemorrhagic conditions	0.624	0.376
Y57 Other and unspecified drugs and medicaments	0.623	0.376
S10 Superficial injury of neck	0.623	0.377
M81.8 Other osteoporosis	0.622	0.377
M81.6 Localised osteoporosis [Lequesne]	0.622	0.377
M81.5 Idiopathic osteoporosis	0.622	0.377
M81.4 Drug-induced osteoporosis	0.622	0.377
M81.3 Postsurgical malabsorption osteoporosis	0.622	0.377
M81.2 Osteoporosis of disuse	0.622	0.377
M81.1 Postoophorectomy osteoporosis	0.622	0.377
M81.0 Postmenopausal osteoporosis	0.622	0.377
S28 Crushing injury of thorax and traumatic amputation of part of thorax	0.622	0.378
S26 Injury of heart	0.622	0.378
S25 Injury of blood vessels of thorax	0.622	0.378
S24 Injury of nerves and spinal cord at thorax level	0.622	0.378
S23 Dislocation, sprain and strain of joints and ligaments of thorax	0.622	0.378
S21 Open wound of thorax	0.622	0.378
I63.9 Cerebral infarction, unspecified	0.622	0.378
E22 Hyperfunction of pituitary gland	0.622	0.378
T42.6 Other antiepileptic and sedative-hypnotic drugs	0.622	0.378
C53 Malignant neoplasm of cervix uteri	0.621	0.379
C71.8 Overlapping lesion of brain	0.621	0.379
C71.7 Brain stem	0.621	0.379
C71.6 Cerebellum	0.621	0.379
C71.5 Cerebral ventricle	0.621	0.379
C71.4 Occipital lobe	0.621	0.379
C71.0 Cerebrum, except lobes and ventricles	0.621	0.379
C22.1 Intrahepatic bile duct carcinoma	0.620	0.380
S73 Dislocation, sprain and strain of joint and ligaments of hip	0.619	0.380
Y59 Other and unspecified vaccines and biological substances	0.619	0.381
Y58 Bacterial vaccines	0.619	0.381
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs	0.619	0.381
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system	0.619	0.381
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism	0.619	0.381
Y53 Agents primarily affecting the gastro-intestinal system	0.619	0.381
Y50 Central nervous system stimulants, not elsewhere classified	0.619	0.381
Y49 Psychotropic drugs, not elsewhere classified	0.619	0.381
Y48 Anaesthetics and therapeutic gases	0.619	0.381
Y47 Sedatives, hypnotics and antianxiety drugs	0.619	0.381
Y46 Antiepileptics and anti-Parkinsonism drugs	0.619	0.381
C16.8 Overlapping lesion of stomach	0.619	0.381
C16.6 Greater curvature of stomach, unspecified	0.619	0.381
C16.5 Lesser curvature of stomach, unspecified	0.619	0.381
C16.4 Pylorus	0.619	0.381
C16.3 Pyloric antrum	0.619	0.381
C16.2 Body of stomach	0.619	0.381
C16.1 Fundus of stomach	0.619	0.381
C18.8 Overlapping lesion of colon	0.618	0.382
C18.3 Hepatic flexure	0.618	0.382
C18.1 Appendix	0.618	0.382
C69.3 Choroid	0.618	0.382
G90-G99 Other disorders of the nervous system	0.618	0.382
Y43 Primarily systemic agents	0.616	0.384
C54.1 Endometrium	0.616	0.384
X51 Travel and motion	0.616	0.384
S70 Superficial injury of hip and thigh	0.615	0.385
E04.8 Other specified non-toxic goitre	0.614	0.386
E04.0 Non-toxic diffuse goitre	0.614	0.386
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.614	0.386
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.614	0.386
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.614	0.386
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.614	0.386
T44 Poisoning by drugs primarily affecting the autonomic nervous system	0.614	0.386
T41 Poisoning by anaesthetics and therapeutic gases	0.614	0.386
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.614	0.386
T36 Poisoning by systemic antibiotics	0.614	0.386
E61 Deficiency of other nutrient elements	0.614	0.386
Y44.2 Anticoagulants	0.613	0.387
R93.6 Abnormal findings on diagnostic imaging of limbs	0.612	0.387
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts	0.612	0.388
R43.8 Other and unspecified disturbances of smell and taste	0.612	0.388
R48 Dyslexia and other symbolic dysfunctions, not elsewhere classified	0.612	0.388
I34.2 Nonrheumatic mitral (valve) stenosis	0.612	0.388
C55 Malignant neoplasm of uterus, part unspecified	0.611	0.389
R93.0 Abnormal findings on diagnostic imaging of skull and head, not elsewhere classified	0.611	0.389
Y51 Drugs primarily affecting the autonomic nervous system	0.611	0.389
R61 Hyperhidrosis	0.610	0.390
M81.97 Osteoporosis, unspecified (Ankle and foot)	0.610	0.390
M81.96 Osteoporosis, unspecified (Lower leg)	0.610	0.390
M81.94 Osteoporosis, unspecified (Hand)	0.610	0.390
M81.93 Osteoporosis, unspecified (Forearm)	0.610	0.390
M81.92 Osteoporosis, unspecified (Upper arm)	0.610	0.390
M81.91 Osteoporosis, unspecified (Shoulder region)	0.610	0.390
E10.8 With unspecified complications	0.610	0.390
E10.7 With multiple complications	0.610	0.390
E10.6 With other specified complications	0.610	0.390
E10.0 With coma	0.610	0.390
R63 Symptoms and signs concerning food and fluid intake	0.610	0.390
T31.0 Burns involving less than 10% of body surface	0.609	0.391
T84.1 Mechanical complication of internal fixation device of bones of limb	0.609	0.391
M93 Other osteochondropathies	0.608	0.392
Q87 Other specified congenital malformation syndromes affecting multiple systems	0.608	0.392
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction	0.607	0.393
Q20-Q28 Congenital malformations of the circulatory system	0.607	0.393
I67.2 Cerebral atherosclerosis	0.607	0.393
E88 Other metabolic disorders	0.607	0.393
I69.3 Sequelae of cerebral infarction	0.607	0.393
T93 Sequelae of injuries of lower limb	0.607	0.393
E34 Other endocrine disorders	0.606	0.394
E85 Amyloidosis	0.606	0.394
E84 Cystic fibrosis	0.606	0.394
E79 Disorders of purine and pyrimidine metabolism	0.606	0.394
E77 Disorders of glycoprotein metabolism	0.606	0.394
E76 Disorders of glycosaminoglycan metabolism	0.606	0.394
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.606	0.394
E74 Other disorders of carbohydrate metabolism	0.606	0.394
E72 Other disorders of amino-acid metabolism	0.606	0.394
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.606	0.394
E70 Disorders of aromatic amino-acid metabolism	0.606	0.394
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.606	0.394
D89 Other disorders involving the immune mechanism, not elsewhere classified	0.606	0.394
S13 Dislocation, sprain and strain of joints and ligaments at neck level	0.604	0.396
I95-I99 Other and unspecified disorders of the circulatory system	0.604	0.396
Y40.0 Penicillins	0.603	0.397
T84.4 Mechanical complication of other internal orthopaedic devices, imnplants and grafts	0.603	0.397

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations