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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs12740374
log Bayes Factor = 128.264
Chromosome 1   position 109,817,590  (GRCh37) Explore rs12740374 on Ensembl!
Variant rs12740374 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E78.5 Hyperlipidaemia, unspecified
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.000 1.000
I20.9 Angina pectoris, unspecified
0.000 0.000 1.000
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.000 1.000
I25.2 Old myocardial infarction
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.000 1.000
Z95.5 Presence of coronary angioplasty implant and graft
0.000 0.000 1.000
Z95.1 Presence of aortocoronary bypass graft
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
I21 Acute myocardial infarction
0.000 0.000 1.000
I20 Angina pectoris
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
I21.9 Acute myocardial infarction, unspecified
0.000 0.000 1.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.000 1.000
Z95 Presence of cardiac and vascular implants and grafts
0.000 0.000 1.000
I20.0 Unstable angina
0.000 0.000 1.000
Z82.4 Family history of ischaemic heart disease and other diseases of the circulatory system
0.000 0.000 1.000
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.001 0.999
Z95.0 Presence of cardiac pacemaker
0.000 0.020 0.980
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.022 0.978
I21.4 Acute subendocardial myocardial infarction
0.000 0.031 0.969
E78.8 Other disorders of lipoprotein metabolism
0.000 0.076 0.924
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.083 0.917
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.093 0.907
I24 Other acute ischaemic heart diseases
0.000 0.119 0.881
I25.3 Aneurysm of heart
0.000 0.135 0.865
Z95.8 Presence of other cardiac and vascular implants and grafts
0.000 0.142 0.858
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.191 0.809
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.000 0.197 0.803
I71 Aortic aneurysm and dissection
0.000 0.200 0.800
E78.4 Other hyperlipidaemia
0.000 0.206 0.794
E78.2 Mixed hyperlipidaemia
0.000 0.208 0.792
I24.8 Other forms of acute ischaemic heart disease
0.000 0.208 0.792
I73 Other peripheral vascular diseases
0.000 0.209 0.791
I73.9 Peripheral vascular disease, unspecified
0.000 0.211 0.789
E78.6 Lipoprotein deficiency
0.000 0.213 0.786
I22 Subsequent myocardial infarction
0.000 0.220 0.780
I20.8 Other forms of angina pectoris
0.000 0.233 0.767
Chapter IX Diseases of the circulatory system
0.000 0.234 0.766
I25.4 Coronary artery aneurysm
0.000 0.236 0.764
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.237 0.763
I74 Arterial embolism and thrombosis
0.000 0.237 0.763
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.000 0.261 0.739
I25.5 Ischaemic cardiomyopathy
0.000 0.270 0.730
I23 Certain current complications following acute myocardial infarction
0.000 0.274 0.725
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.280 0.720
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
E78.3 Hyperchylomicronaemia
0.000 0.283 0.717
E78.1 Pure hyperglyceridaemia
0.000 0.288 0.712
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.309 0.691
I71.3 Abdominal aortic aneurysm, ruptured
0.000 0.354 0.646
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.358 0.642
I20.1 Angina pectoris with documented spasm
0.000 0.368 0.632
I70 Atherosclerosis
0.000 0.393 0.607
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.000 0.393 0.607
I74.8 Embolism and thrombosis of other arteries
0.000 0.410 0.590
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.414 0.586
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.415 0.585
I22.8 Subsequent myocardial infarction of other sites
0.000 0.423 0.576
I72 Other aneurysm
0.000 0.426 0.574
Z95.2 Presence of prosthetic heart valve
0.000 0.427 0.573
I71.8 Aortic aneurysm of unspecified site, ruptured
0.000 0.427 0.573
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.000 0.427 0.573
I71.1 Thoracic aortic aneurysm, ruptured
0.000 0.427 0.573
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.000 0.429 0.571
I74.0 Embolism and thrombosis of abdominal aorta
0.000 0.437 0.563
I24.1 Dressler's syndrome
0.000 0.439 0.561
I73.8 Other specified peripheral vascular diseases
0.000 0.446 0.554
I77 Other disorders of arteries and arterioles
0.000 0.453 0.547
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.000 0.453 0.547
I00-I02 Acute rheumatic fever
0.000 0.455 0.544
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.000 0.462 0.538
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.000 0.463 0.537
I23.8 Other current complications following acute myocardial infarction
0.000 0.471 0.529
Z95.9 Presence of cardiac and vascular implant and graft, unspecified
0.000 0.472 0.528
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.480 0.520
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.480 0.520
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.480 0.520
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.480 0.520
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.480 0.520
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.480 0.520
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.480 0.520
I73.1 Thromboangiitis obliterans [Buerger]
0.000 0.493 0.507
I72.4 Aneurysm of artery of lower extremity
0.000 0.499 0.501
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.504 0.495
I79.1 Aortitis in diseases classified elsewhere
0.000 0.504 0.495
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.000 0.504 0.495
I74.9 Embolism and thrombosis of unspecified artery
0.000 0.509 0.491
Z82 Family history of certain disabilities and chronic diseases leading to disablement
0.000 0.510 0.490
I70.2 Atherosclerosis of arteries of the extremities
0.000 0.514 0.485
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.518 0.482
I10-I15 Hypertensive diseases
0.000 0.518 0.482
I71.0 Dissection of aorta [any part]
0.000 0.521 0.478
I21.3 Acute transmural myocardial infarction of unspecified site
0.001 0.527 0.473
I50 Heart failure
0.000 0.531 0.469
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.532 0.468
I30-I52 Other forms of heart disease
0.000 0.536 0.464
I72.3 Aneurysm of iliac artery
0.000 0.538 0.462
I50.1 Left ventricular failure
0.000 0.544 0.456
I35.0 Aortic (valve) stenosis
0.000 0.555 0.445
I50.0 Congestive heart failure
0.000 0.555 0.445
I35 Nonrheumatic aortic valve disorders
0.000 0.558 0.442
I70.1 Atherosclerosis of renal artery
0.000 0.559 0.441
I77.1 Stricture of artery
0.000 0.559 0.441
I70.8 Atherosclerosis of other arteries
0.000 0.563 0.437
I70.9 Generalised and unspecified atherosclerosis
0.000 0.565 0.435
I74.5 Embolism and thrombosis of iliac artery
0.000 0.569 0.431
I72.2 Aneurysm of renal artery
0.000 0.578 0.422
I78 Diseases of capillaries
0.000 0.581 0.419
I77.6 Arteritis, unspecified
0.000 0.584 0.416
Z82.7 Family history of congenital malformations, deformations and chromosomal abnormalities
0.000 0.586 0.414
I15 Secondary hypertension
0.000 0.587 0.413
I72.6 Aneurysm and dissection of vertebral artery
0.000 0.589 0.411
I72.5 Aneurysm and dissection of other precerebral arteries
0.000 0.589 0.411
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.000 0.589 0.411
I45 Other conduction disorders
0.000 0.598 0.402
I77.2 Rupture of artery
0.000 0.601 0.399
I45.1 Other and unspecified right bundle-branch block
0.000 0.603 0.397
I70.0 Atherosclerosis of aorta
0.000 0.606 0.394
I77.5 Necrosis of artery
0.000 0.607 0.392
I77.4 Coeliac artery compression syndrome
0.000 0.607 0.392
I77.3 Arterial fibromuscular dysplasia
0.000 0.607 0.392
I50.9 Heart failure, unspecified
0.000 0.608 0.392
I70.21 Atherosclerosis of arteries of extremities (with gangrene)
0.000 0.609 0.391
I02 Rheumatic chorea
0.000 0.609 0.390
I01 Rheumatic fever with heart involvement
0.000 0.609 0.390
Z82.2 Family history of deafness and hearing loss
0.000 0.612 0.388
Z82.6 Family history of arthritis and other diseases of the musculoskeletal system and connective tissue
0.000 0.614 0.386
I00 Rheumatic fever without mention of heart involvement
0.000 0.614 0.386
Z82.0 Family history of epilepsy and other diseases of the nervous system
0.000 0.614 0.386
I11 Hypertensive heart disease
0.000 0.616 0.383
I72.8 Aneurysm of other specified arteries
0.000 0.633 0.367
I77.9 Disorder of arteries and arterioles, unspecified
0.000 0.635 0.365
I46 Cardiac arrest
0.000 0.637 0.363
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.000 0.638 0.362
I70.20 Atherosclerosis of arteries of extremities (without gangrene)
0.000 0.641 0.359
I72.1 Aneurysm of artery of upper extremity
0.000 0.642 0.358
I77.8 Other specified disorders of arteries and arterioles
0.000 0.643 0.357
I72.9 Aneurysm of unspecified site
0.000 0.644 0.356
Z82.8 Family history of other disabilities and chronic diseases leading to disablement, not elsewhere classified
0.000 0.648 0.352
Z82.5 Family history of asthma and other chronic lower respiratory diseases
0.000 0.652 0.348
I13 Hypertensive heart and renal disease
0.000 0.654 0.346
I33 Acute and subacute endocarditis
0.000 0.661 0.339
I15.9 Seconday hypertension, unspecified
0.000 0.661 0.339
I40 Acute myocarditis
0.000 0.663 0.337
I15.1 Hypertension secondary to other renal disorders
0.000 0.664 0.336
I35.8 Other aortic valve disorders
0.000 0.667 0.333
I52 Other heart disorders in diseases classified elsewhere
0.000 0.667 0.332
I48 Atrial fibrillation and flutter
0.000 0.667 0.332
I43 Cardiomyopathy in diseases classified elsewhere
0.000 0.667 0.332
I41 Myocarditis in diseases classified elsewhere
0.000 0.667 0.332
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.000 0.667 0.332
I32 Pericarditis in diseases classified elsewhere
0.000 0.667 0.332
Z95.3 Presence of xenogenic heart valve
0.001 0.670 0.329
I34 Nonrheumatic mitral valve disorders
0.000 0.674 0.326
S00.8 Superficial injury of other parts of head
0.000 0.674 0.326
I70.10 Atherosclerosis of renal artery (without gangrene)
0.000 0.678 0.322
I45.2 Bifascicular block
0.000 0.681 0.319
I46.0 Cardiac arrest with successful resuscitation
0.000 0.681 0.319
I70.11 Atherosclerosis of renal artery (with gangrene)
0.000 0.684 0.316
I77.0 Arteriovenous fistula, acquired
0.000 0.684 0.316
I70.80 Atherosclerosis of other arteries (without gangrene)
0.000 0.684 0.316
I72.0 Aneurysm of carotid artery
0.000 0.685 0.314
Z82.1 Family history of blindness and visual loss
0.000 0.686 0.314
I70.81 Atherosclerosis of other arteries (with gangrene)
0.000 0.686 0.314
I11.0 Hypertensive heart disease with (congestive) heart failure
0.000 0.687 0.313
I42 Cardiomyopathy
0.000 0.687 0.313
I70.91 Generalized and unspecified atherosclerosis (with gangrene)
0.000 0.688 0.312
I70.90 Generalized and unspecified atherosclerosis (without gangrene)
0.000 0.688 0.312
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.000 0.697 0.303
I34.1 Mitral (valve) prolapse
0.000 0.699 0.301
I78.0 Hereditary haemorrhagic telangiectasia
0.000 0.699 0.301
I78.9 Disease of capillaries, unspecified
0.000 0.699 0.300
I28 Other diseases of pulmonary vessels
0.000 0.702 0.298
I15.8 Other secondary hypertension
0.000 0.703 0.296
I15.2 Hypertension secondary to endocrine disorders
0.000 0.703 0.296
I15.0 Renovascular hypertension
0.000 0.703 0.296
I05-I09 Chronic rheumatic heart diseases
0.000 0.710 0.290
I78.8 Other diseases of capillaries
0.000 0.710 0.290
I45.0 Right fascicular block
0.000 0.712 0.288
I95-I99 Other and unspecified disorders of the circulatory system
0.000 0.716 0.284
I45.5 Other specified heart block
0.000 0.717 0.283
I70.01 Atherosclerosis of aorta (with gangrene)
0.000 0.717 0.282
I01.9 Acute rheumatic heart disease, unspecified
0.000 0.720 0.280
I01.8 Other acute rheumatic heart disease
0.000 0.720 0.280
I01.2 Acute rheumatic myocarditis
0.000 0.720 0.280
I01.1 Acute rheumatic endocarditis
0.000 0.720 0.280
I01.0 Acute rheumatic pericarditis
0.000 0.720 0.280
I02.9 Rheumatic chorea without heart involvement
0.000 0.720 0.280
I02.0 Rheumatic chorea with heart involvement
0.000 0.720 0.280
S00 Superficial injury of head
0.000 0.724 0.276
I45.3 Trifascicular block
0.000 0.724 0.276
I11.9 Hypertensive heart disease without (congestive) heart failure
0.000 0.724 0.276
I33.0 Acute and subacute infective endocarditis
0.000 0.729 0.271
I42.8 Other cardiomyopathies
0.000 0.730 0.270
O34.2 Maternal care due to uterine scar from previous surgery
0.267 0.733 0.000
I30 Acute pericarditis
0.000 0.737 0.263
I46.1 Sudden cardiac death, so described
0.000 0.740 0.260
I37 Pulmonary valve disorders
0.000 0.743 0.257
I42.2 Other hypertrophic cardiomyopathy
0.000 0.745 0.255
I10 Essential (primary) hypertension
0.000 0.747 0.253
I28.8 Other specified diseases of pulmonary vessels
0.000 0.747 0.252
S00.0 Superficial injury of scalp
0.000 0.749 0.251
I35.9 Aortic valve disorder, unspecified
0.000 0.750 0.250
I45.9 Conduction disorder, unspecified
0.000 0.751 0.249
I35.2 Aortic (valve) stenosis with insufficiency
0.000 0.751 0.249
I13.9 Hypertensive heart and renal disease, unspecified
0.000 0.752 0.248
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure
0.000 0.752 0.248
I13.1 Hypertensive heart and renal disease with renal failure
0.000 0.752 0.248
I13.0 Hypertensive heart and renal disease with (congestive) heart failure
0.000 0.752 0.248
I38 Endocarditis, valve unspecified
0.000 0.754 0.246
I40.0 Infective myocarditis
0.000 0.754 0.246
S00.7 Multiple superficial injuries of head
0.000 0.754 0.246
I40.9 Acute myocarditis, unspecified
0.000 0.758 0.242
I40.8 Other acute myocarditis
0.000 0.758 0.242
I40.1 Isolated myocarditis
0.000 0.758 0.242
I70.00 Atherosclerosis of aorta (without gangrene)
0.000 0.759 0.241
I32.8 Pericarditis in other diseases classified elsewhere
0.000 0.761 0.238
I32.1 Pericarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.761 0.238
I32.0 Pericarditis in bacterial diseases classified elsewhere
0.000 0.761 0.238
I39.8 Endocarditis, valve unspecified, in diseases classified elsewhere
0.000 0.761 0.238
I39.4 Multiple valve disorders in diseases classified elsewhere
0.000 0.761 0.238
I39.3 Pulmonary valve disorders in diseases classified elsewhere
0.000 0.761 0.238
I39.2 Tricuspid valve disorders in diseases classified elsewhere
0.000 0.761 0.238
I39.1 Aortic valve disorders in diseases classified elsewhere
0.000 0.761 0.238
I39.0 Mitral valve disorders in diseases classified elsewhere
0.000 0.761 0.238
I41.8 Myocarditis in other diseases classified elsewhere
0.000 0.761 0.238
I41.2 Myocarditis in other infectious and parasitic diseases classified elsewhere
0.000 0.761 0.238
I41.1 Myocarditis in viral diseases classified elsewhere
0.000 0.761 0.238
I41.0 Myocarditis in bacterial diseases classified elsewhere
0.000 0.761 0.238
I43.8 Cardiomyopathy in other diseases classified elsewhere
0.000 0.761 0.238
I43.2 Cardiomyopathy in nutritional diseases
0.000 0.761 0.238
I43.1 Cardiomyopathy in metabolic diseases
0.000 0.761 0.238
I43.0 Cardiomyopathy in infectious and parasitic diseases classified elsewhere
0.000 0.761 0.238
I48.9 Atrial fibrillation and atrial flutter, unspecified
0.000 0.761 0.238
I48.4 Atypical atrial flutter
0.000 0.761 0.238
I48.3 Typical atrial flutter
0.000 0.761 0.238
I48.2 Chronic atrial fibrillation
0.000 0.761 0.238
I48.1 Persistent atrial fibrillation
0.000 0.761 0.238
I48.0 Paroxysmal atrial fibrillation
0.000 0.761 0.238
I52.8 Other heart disorders in other diseases classified elsewhere
0.000 0.761 0.238
I52.1 Other heart disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.761 0.238
I52.0 Other heart disorders in bacterial diseases classified elsewhere
0.000 0.761 0.238
I36 Nonrheumatic tricuspid valve disorders
0.001 0.763 0.237
I42.1 Obstructive hypertrophic cardiomyopathy
0.000 0.773 0.227
I73.0 Raynaud's syndrome
0.000 0.774 0.226
I42.7 Cardiomyopathy due to drugs and other external agents
0.000 0.776 0.224
I42.5 Other restrictive cardiomyopathy
0.000 0.776 0.224
I42.4 Endocardial fibroelastosis
0.000 0.776 0.224
I42.3 Endomyocardial (eosinophilic) disease
0.000 0.776 0.224
I09 Other rheumatic heart diseases
0.000 0.783 0.216
I42.6 Alcoholic cardiomyopathy
0.000 0.784 0.216
I99 Other and unspecified disorders of circulatory system
0.000 0.785 0.215
I28.9 Disease of pulmonary vessels, unspecified
0.000 0.786 0.214
I28.1 Aneurysm of pulmonary artery
0.000 0.786 0.214
I28.0 Arteriovenous fistula of pulmonary vessels
0.000 0.786 0.214
I33.9 Acute endocarditis, unspecified
0.000 0.787 0.213
I45.8 Other specified conduction disorders
0.000 0.788 0.212
I34.0 Mitral (valve) insufficiency
0.000 0.788 0.212
S00.2 Other superficial injuries of eyelid and periocular area
0.000 0.790 0.210
I45.4 Nonspecific intraventricular block
0.000 0.791 0.209
S00.1 Contusion of eyelid and periocular area
0.000 0.797 0.203
I06 Rheumatic aortic valve diseases
0.000 0.798 0.202
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.799 0.201
I34.8 Other nonrheumatic mitral valve disorders
0.000 0.801 0.199
I07 Rheumatic tricuspid valve diseases
0.000 0.803 0.197
S00.5 Superficial injury of lip and oral cavity
0.000 0.804 0.196
I46.9 Cardiac arrest, unspecified
0.000 0.806 0.194
S00.3 Superficial injury of nose
0.000 0.807 0.193
I34.2 Nonrheumatic mitral (valve) stenosis
0.000 0.809 0.191
I30.8 Other forms of acute pericarditis
0.000 0.811 0.188
I30.0 Acute nonspecific idiopathic pericarditis
0.000 0.811 0.188
I37.9 Pulmonary valve disorder, unspecified
0.000 0.816 0.184
I37.8 Other pulmonary valve disorders
0.000 0.816 0.184
I37.2 Pulmonary valve stenosis with insufficiency
0.000 0.816 0.184
I37.0 Pulmonary valve stenosis
0.000 0.816 0.184
I34.9 Nonrheumatic mitral valve disorder, unspecified
0.000 0.816 0.184
I45.6 Preexcitation syndrome
0.000 0.821 0.178
I05 Rheumatic mitral valve diseases
0.000 0.826 0.174
I42.9 Cardiomyopathy, unspecified
0.000 0.829 0.171
I36.9 Nonrheumatic tricuspid valve disorder, unspecified
0.001 0.830 0.170
I36.8 Other nonrheumatic tricuspid valve disorders
0.001 0.830 0.170
I36.2 Nonrheumatic tricuspid (valve) stenosis with insufficiency
0.001 0.830 0.170
I36.0 Nonrheumatic tricuspid (valve) stenosis
0.001 0.830 0.170
S00.4 Superficial injury of ear
0.000 0.831 0.169
I09.9 Rheumatic heart disease, unspecified
0.000 0.836 0.164
S00.9 Superficial injury of head, part unspecified
0.000 0.837 0.163
I78.1 Naevus, nonneoplastic
0.000 0.838 0.162
I30.1 Infective pericarditis
0.000 0.838 0.162
I97.1 Other functional disturbances following cardiac surgery
0.000 0.838 0.162
O34 Maternal care for known or suspected abnormality of pelvic organs
0.158 0.842 0.000
I30.9 Acute pericarditis, unspecified
0.000 0.844 0.156
I09.8 Other specified rheumatic heart diseases
0.000 0.845 0.155
I09.2 Chronic rheumatic pericarditis
0.000 0.845 0.155
I09.1 Rheumatic diseases of endocardium, valve unspecified
0.000 0.845 0.155
I09.0 Rheumatic myocarditis
0.000 0.845 0.155
I27 Other pulmonary heart diseases
0.000 0.849 0.151
I12 Hypertensive renal disease
0.000 0.850 0.150
Z82.3 Family history of stroke
0.000 0.853 0.146
I97.2 Postmastectomy lymphoedema syndrome
0.000 0.854 0.146
I06.9 Rheumatic aortic valve disease, unspecified
0.000 0.855 0.145
I06.8 Other rheumatic aortic valve diseases
0.000 0.855 0.145
I06.2 Rheumatic aortic stenosis with insufficiency
0.000 0.855 0.145
I06.0 Rheumatic aortic stenosis
0.000 0.855 0.145
I97.9 Postprocedural disorder of circulatory system, unspecified
0.000 0.856 0.144
I97.0 Postcardiotomy syndrome
0.000 0.856 0.144
I05.2 Mitral stenosis with insufficiency
0.000 0.857 0.143
I07.9 Tricuspid valve disease, unspecified
0.000 0.859 0.141
I07.8 Other tricuspid valve diseases
0.000 0.859 0.141
I07.2 Tricuspid stenosis with insufficiency
0.000 0.859 0.141
I07.0 Tricuspid stenosis
0.000 0.859 0.141
I06.1 Rheumatic aortic insufficiency
0.000 0.861 0.139
I26 Pulmonary embolism
0.002 0.861 0.137
I98 Other disorders of circulatory system in diseases classified elsewhere
0.000 0.867 0.133
O34.0 Maternal care for congenital malformation of uterus
0.130 0.870 0.000
I07.1 Tricuspid insufficiency
0.000 0.870 0.130
I31 Other diseases of pericardium
0.000 0.871 0.129
O34.8 Maternal care for other abnormalities of pelvic organs
0.127 0.873 0.000
I05.8 Other mitral valve diseases
0.000 0.875 0.125
I05.1 Rheumatic mitral insufficiency
0.000 0.880 0.120
S00-S09 Injuries to the head
0.000 0.880 0.120
I05.0 Mitral stenosis
0.000 0.881 0.119
I27.9 Pulmonary heart disease, unspecified
0.000 0.882 0.118
O34.1 Maternal care for tumour of corpus uteri
0.116 0.884 0.000
O34.9 Maternal care for abnormality of pelvic organ, unspecified
0.113 0.887 0.000
O34.6 Maternal care for abnormality of vagina
0.113 0.887 0.000
O34.5 Maternal care for other abnormalities of gravid uterus
0.113 0.887 0.000
I27.8 Other specified pulmonary heart diseases
0.000 0.887 0.113
O34.7 Maternal care for abnormality of vulva and perineum
0.112 0.888 0.000
I42.0 Dilated cardiomyopathy
0.000 0.889 0.111
O34.3 Maternal care for cervical incompetence
0.111 0.889 0.000
I97.8 Other postprocedural disorders of circulatory system, not elsewhere classified
0.000 0.889 0.110
I37.1 Pulmonary valve insufficiency
0.001 0.891 0.108
I27.1 Kyphoscoliotic heart disease
0.000 0.891 0.108
O34.4 Maternal care for other abnormalities of cervix
0.108 0.892 0.000
S02 Fracture of skull and facial bones
0.000 0.894 0.106
S02.0 Fracture of vault of skull
0.000 0.897 0.103
S02.00 Fracture of vault of skull (closed)
0.000 0.899 0.101
S02.2 Fracture of nasal bones
0.000 0.904 0.096
I98.8 Other specified disorders of circulatory system in diseases classified elsewhere
0.000 0.904 0.096
I98.1 Cardiovascular disorders in other infectious and parasitic diseases classified elsewhere
0.000 0.904 0.096
I98.0 Cardiovascular syphilis
0.000 0.904 0.096
I31.8 Other specified diseases of pericardium
0.000 0.907 0.093
I31.2 Haemopericardium, not elsewhere classified
0.000 0.907 0.093
I26.0 Pulmonary embolism with mention of acute cor pulmonale
0.001 0.907 0.091
S01 Open wound of head
0.000 0.908 0.092
Z95.4 Presence of other heart-valve replacement
0.000 0.909 0.091
I51 Complications and ill-defined descriptions of heart disease
0.000 0.910 0.089
S01.9 Open wound of head, part unspecified
0.000 0.911 0.089
I98.3 Oesophageal varices with bleeding in diseases classified elsewhere
0.000 0.911 0.089
S09 Other and unspecified injuries of head
0.000 0.911 0.089
S02.20 Fracture of nasal bones (closed)
0.000 0.911 0.089
S08 Traumatic amputation of part of head
0.000 0.914 0.086
S07 Crushing injury of head
0.000 0.914 0.086
S04 Injury of cranial nerves
0.000 0.914 0.086
K05.3 Chronic periodontitis
0.086 0.914 0.000
S01.7 Multiple open wounds of head
0.000 0.917 0.083
S05 Injury of eye and orbit
0.000 0.917 0.083
S03 Dislocation, sprain and strain of joints and ligaments of head
0.000 0.917 0.083
I95 Hypotension
0.000 0.921 0.079
S02.8 Fractures of other skull and facial bones
0.000 0.921 0.079
S02.7 Multiple fractures involving skull and facial bones
0.000 0.922 0.078
I31.0 Chronic adhesive pericarditis
0.000 0.922 0.078
I12.9 Hypertensive renal disease without renal failure
0.000 0.923 0.077
I31.1 Chronic constrictive pericarditis
0.000 0.923 0.076
S02.9 Fracture of skull and facial bones, part unspecified
0.000 0.924 0.076
S09.8 Other specified injuries of head
0.000 0.924 0.076
I36.1 Nonrheumatic tricuspid (valve) insufficiency
0.001 0.924 0.074
S02.01 Fracture of vault of skull (open)
0.000 0.926 0.074
I49 Other cardiac arrhythmias
0.000 0.928 0.072
S01.1 Open wound of eyelid and periocular area
0.000 0.929 0.071
I51.0 Cardiac septal defect, acquired
0.000 0.930 0.070
S01.3 Open wound of ear
0.000 0.930 0.070
S02.6 Fracture of mandible
0.000 0.930 0.070
I31.3 Pericardial effusion (noninflammatory)
0.000 0.930 0.070
I08 Multiple valve diseases
0.000 0.930 0.070
S02.21 Fracture of nasal bones (open)
0.000 0.931 0.069
I05.9 Mitral valve disease, unspecified
0.000 0.933 0.066
S05.8 Other injuries of eye and orbit
0.000 0.934 0.066
S03.2 Dislocation of tooth
0.000 0.935 0.065
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.000 0.935 0.065
S01.2 Open wound of nose
0.000 0.935 0.065
S02.3 Fracture of orbital floor
0.000 0.935 0.064
I51.2 Rupture of papillary muscle, not elsewhere classified
0.000 0.936 0.064
S09.7 Multiple injuries of head
0.000 0.936 0.064
S09.2 Traumatic rupture of ear drum
0.000 0.936 0.064
S09.1 Injury of muscle and tendon of head
0.000 0.936 0.064
I49.5 Sick sinus syndrome
0.000 0.937 0.063
S05.1 Contusion of eyeball and orbital tissues
0.000 0.938 0.062
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.000 0.938 0.062
S04.9 Injury of unspecified cranial nerve
0.000 0.938 0.062
S04.8 Injury of other cranial nerves
0.000 0.938 0.062
S04.7 Injury of accessory nerve
0.000 0.938 0.062
S04.6 Injury of acoustic nerve
0.000 0.938 0.062
S04.5 Injury of facial nerve
0.000 0.938 0.062
S04.4 Injury of abducent nerve
0.000 0.938 0.062
S04.3 Injury of trigeminal nerve
0.000 0.938 0.062
S04.2 Injury of trochlear nerve
0.000 0.938 0.062
S04.1 Injury of oculomotor nerve
0.000 0.938 0.062
S04.0 Injury of optic nerve and pathways
0.000 0.938 0.062
S07.9 Crushing injury of head, part unspecified
0.000 0.938 0.062
S07.8 Crushing injury of other parts of head
0.000 0.938 0.062
S07.1 Crushing injury of skull
0.000 0.938 0.062
S07.0 Crushing injury of face
0.000 0.938 0.062
S08.9 Traumatic amputation of unspecified part of head
0.000 0.938 0.062
S08.8 Traumatic amputation of other parts of head
0.000 0.938 0.062
S08.1 Traumatic amputation of ear
0.000 0.938 0.062
S08.0 Avulsion of scalp
0.000 0.938 0.062
I27.0 Primary pulmonary hypertension
0.000 0.938 0.061
S05.7 Avulsion of eye
0.000 0.940 0.060
S05.6 Penetrating wound of eyeball without foreign body
0.000 0.940 0.060
S05.5 Penetrating wound of eyeball with foreign body
0.000 0.940 0.060
S05.4 Penetrating wound of orbit with or without foreign body
0.000 0.940 0.060
S05.2 Ocular laceration and rupture with prolapse or loss of intraocular tissue
0.000 0.940 0.060
S03.5 Sprain and strain of joints and ligaments of other and unspecified parts of head
0.000 0.940 0.059
S03.4 Sprain and strain of jaw
0.000 0.940 0.059
S03.3 Dislocation of other and unspecified parts of head
0.000 0.940 0.059
S03.0 Dislocation of jaw
0.000 0.940 0.059
S05.3 Ocular laceration without prolapse or loss of intraocular tissue
0.000 0.941 0.059
S09.0 Injury of blood vessels of head, not elsewhere classified
0.000 0.941 0.059
S02.80 Fractures of other skull and facial bones (closed)
0.000 0.941 0.059
I51.8 Other ill-defined heart diseases
0.000 0.941 0.059
I51.9 Heart disease, unspecified
0.000 0.941 0.059
S05.9 Injury of eye and orbit, part unspecified
0.000 0.941 0.059
S02.70 Multiple fractures involving skull and facial bones (closed)
0.000 0.941 0.058
S02.4 Fracture of malar and maxillary bones
0.000 0.942 0.058
S02.1 Fracture of base of skull
0.000 0.942 0.058
S02.81 Fractures of other skull and facial bones (open)
0.000 0.943 0.057
I49.1 Atrial premature depolarisation
0.000 0.943 0.057
I51.6 Cardiovascular disease, unspecified
0.000 0.943 0.056
S02.71 Multiple fractures involving skull and facial bones (open)
0.000 0.943 0.056
I31.9 Disease of pericardium, unspecified
0.000 0.944 0.056
S02.5 Fracture of tooth
0.000 0.944 0.056
I51.3 Intracardiac thrombosis, not elsewhere classified
0.000 0.944 0.056
K05 Gingivitis and periodontal diseases
0.055 0.945 0.000
S02.91 Fracture of skull and facial bones, part unspecified (open)
0.000 0.945 0.055
S02.90 Fracture of skull and facial bones, part unspecified (closed)
0.000 0.945 0.055
S01.4 Open wound of cheek and temporomandibular area
0.000 0.945 0.055
I47 Paroxysmal tachycardia
0.000 0.946 0.054
S09.9 Unspecified injury of head
0.000 0.947 0.053
I51.5 Myocardial degeneration
0.000 0.947 0.052
I49.2 Junctional premature depolarisation
0.000 0.948 0.052
I95.9 Hypotension, unspecified
0.000 0.948 0.052
S02.61 Fracture of mandible (open)
0.000 0.949 0.050
I95.1 Orthostatic hypotension
0.000 0.950 0.050
I49.8 Other specified cardiac arrhythmias
0.000 0.950 0.050
S03.1 Dislocation of septal cartilage of nose
0.000 0.951 0.049
K05.6 Periodontal disease, unspecified
0.049 0.951 0.000
I51.7 Cardiomegaly
0.000 0.952 0.048
I27.2 Other secondary pulmonary hypertension
0.000 0.952 0.048
S02.31 Fracture of orbital floor (open)
0.000 0.953 0.046
I95.2 Hypotension due to drugs
0.000 0.954 0.046
I08.9 Multiple valve disease, unspecified
0.000 0.954 0.045
S02.60 Fracture of mandible (closed)
0.000 0.956 0.044
S05.0 Injury of conjunctiva and corneal abrasion without mention of foreign body
0.000 0.956 0.044
I08.2 Disorders of both aortic and tricuspid valves
0.000 0.956 0.044
K05.1 Chronic gingivitis
0.043 0.957 0.000
I35.1 Aortic (valve) insufficiency
0.001 0.957 0.042
I95.0 Idiopathic hypotension
0.000 0.958 0.042
S02.41 Fracture of malar and maxillary bones (open)
0.000 0.958 0.042
I98.2 Oesophageal varices in diseases classified elsewhere
0.000 0.959 0.041
I95.8 Other hypotension
0.000 0.959 0.041
S02.51 Fracture of tooth (open)
0.000 0.959 0.040
I49.4 Other and unspecified premature depolarisation
0.000 0.960 0.040
K05.2 Acute periodontitis
0.040 0.960 0.000
K05.4 Periodontosis
0.040 0.960 0.000
K05.0 Acute gingivitis
0.040 0.960 0.000
S01.5 Open wound of lip and oral cavity
0.000 0.960 0.040
I08.8 Other multiple valve diseases
0.000 0.961 0.039
K05.5 Other periodontal diseases
0.036 0.964 0.000
S02.11 Fracture of base of skull (open)
0.000 0.965 0.034
S02.30 Fracture of orbital floor (closed)
0.000 0.965 0.035
S06 Intracranial injury
0.000 0.965 0.035
S02.10 Fracture of base of skull (closed)
0.000 0.966 0.034
I47.0 Reentry ventricular arrhythmia
0.000 0.967 0.032
I51.4 Myocarditis, unspecified
0.001 0.968 0.031
S06.3 Focal brain injury
0.000 0.971 0.029
K05.22 Aggressive periodontitis, generalized
0.029 0.971 0.000
I47.2 Ventricular tachycardia
0.000 0.972 0.028
I49.0 Ventricular fibrillation and flutter
0.000 0.973 0.027
S06.30 Focal brain injury (without open intracranial wound)
0.000 0.975 0.025
S06.7 Intracranial injury with prolonged coma
0.000 0.975 0.025
S06.1 Traumatic cerebral oedema
0.000 0.975 0.025
S01.8 Open wound of other parts of head
0.000 0.975 0.025
S02.40 Fracture of malar and maxillary bones (closed)
0.000 0.976 0.024
S06.4 Epidural haemorrhage
0.000 0.977 0.023
S06.9 Intracranial injury, unspecified
0.000 0.977 0.023
I60-I69 Cerebrovascular diseases
0.000 0.978 0.022
S06.2 Diffuse brain injury
0.000 0.978 0.022
S06.31 Focal brain injury (with open intracranial wound)
0.000 0.979 0.021
S01.0 Open wound of scalp
0.000 0.979 0.021
S02.50 Fracture of tooth (closed)
0.001 0.979 0.020
S06.6 Traumatic subarachnoid haemorrhage
0.000 0.979 0.020
S06.0 Concussion
0.000 0.979 0.020
S06.8 Other intracranial injuries
0.000 0.980 0.019
S06.5 Traumatic subdural haemorrhage
0.000 0.981 0.019
I69 Sequelae of cerebrovascular disease
0.000 0.981 0.019
I08.0 Disorders of both mitral and aortic valves
0.000 0.981 0.019
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.000 0.981 0.018

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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