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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs16861232
log Bayes Factor = 10.0701
Chromosome 3   position 148,682,436  (GRCh37) Explore rs16861232 on Ensembl!
Variant rs16861232 is part of Cluster X0263

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter II Neoplasms
0.999 0.001 0.000
M45-M49 Spondylopathies
0.998 0.002 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.994 0.006 0.000
M50-M54 Other dorsopathies
0.993 0.007 0.000
Chapter XX External causes of morbidity and mortality
0.990 0.010 0.000
M05-M14 Inflammatory polyarthropathies
0.988 0.012 0.000
C64-C68 Malignant neoplasms of urinary tract
0.988 0.012 0.000
Z87 Personal history of other diseases and conditions
0.983 0.017 0.000
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status
0.983 0.017 0.000
Chapter XXI Factors influencing health status and contact with health services
0.982 0.018 0.000
M06 Other rheumatoid arthritis
0.982 0.018 0.000
Z85 Personal history of malignant neoplasm
0.982 0.018 0.000
M48 Other spondylopathies
0.981 0.019 0.000
Z87.0 Personal history of diseases of the respiratory system
0.980 0.020 0.000
M50 Cervical disk disorders
0.980 0.020 0.000
Z87.3 Personal history of diseases of the musculoskeletal system and connective tissue
0.978 0.022 0.000
S80-S89 Injuries to the knee and lower leg
0.974 0.026 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.973 0.027 0.000
M06.9 Rheumatoid arthritis, unspecified
0.973 0.027 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.972 0.028 0.000
M48.0 Spinal stenosis
0.968 0.032 0.000
Chapter VI Diseases of the nervous system
0.968 0.032 0.000
C67 Malignant neoplasm of bladder
0.967 0.033 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.961 0.039 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.960 0.040 0.000
M47 Spondylosis
0.951 0.049 0.000
C50-C50 Malignant neoplasm of breast
0.951 0.049 0.000
Z85.8 Personal history of malignant neoplasms of other organs and systems
0.945 0.055 0.000
Z85.7 Personal history of other malignant neoplasms of lymphoid, haematopoietic and related tissues
0.940 0.060 0.000
S82 Fracture of lower leg, including ankle
0.940 0.060 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.939 0.061 0.000
Z85.3 Personal history of malignant neoplasm of breast
0.934 0.066 0.000
S00-S09 Injuries to the head
0.934 0.066 0.000
T66-T78 Other and unspecified effects of external causes
0.930 0.070 0.000
M50.2 Other cervical disk displacement
0.929 0.071 0.000
M80-M85 Disorders of bone density and structure
0.927 0.073 0.000
S82.8 Fractures of other parts of lower leg
0.917 0.083 0.000
C50 Malignant neoplasm of breast
0.916 0.084 0.000
M47.8 Other spondylosis
0.913 0.087 0.000
C67.9 Bladder, unspecified
0.911 0.089 0.000
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites
0.909 0.091 0.000
Z98 Other postsurgical states
0.905 0.095 0.000
M50.3 Other cervical disk degeneration
0.905 0.095 0.000
C50.4 Upper-outer quadrant of breast
0.905 0.095 0.000
Z88 Personal history of allergy to drugs, medicaments and biologocal substances
0.904 0.096 0.000
S82.80 Fractures of other parts of lower leg (closed)
0.901 0.099 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.899 0.101 0.000
M48.06 Spinal stenosis (Lumbar region)
0.899 0.101 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.898 0.102 0.000
M91-M94 Chondropathies
0.885 0.115 0.000
S10-S19 Injuries to the neck
0.880 0.120 0.000
T78 Adverse effects, not elsewhere classified
0.880 0.120 0.000
M05 Seropositive rheumatoid arthritis
0.879 0.120 0.000
C64 Malignant neoplasm of kidney, except renal pelvis
0.879 0.121 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.879 0.121 0.000
Z88.6 Personal history of allergy to analgesic agent
0.878 0.122 0.000
C02 Malignant neoplasm of other and unspecified parts of tongue
0.877 0.123 0.000
Z94 Transplanted organ and tissue status
0.873 0.127 0.000
S01 Open wound of head
0.872 0.128 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.868 0.132 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.868 0.132 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.866 0.134 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.866 0.134 0.000
M86-M90 Other osteopathies
0.865 0.135 0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.863 0.137 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.863 0.137 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.860 0.140 0.000
M48.09 Spinal stenosis (Site unspecified)
0.859 0.141 0.000
S50-S59 Injuries to the elbow and forearm
0.855 0.145 0.000
G90-G99 Other disorders of the nervous system
0.855 0.145 0.000
M48.07 Spinal stenosis (Lumbosacral region)
0.853 0.147 0.000
Y43 Primarily systemic agents
0.852 0.148 0.000
S81 Open wound of lower leg
0.844 0.156 0.000
D48.1 Connective and other soft tissue
0.844 0.156 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.844 0.156 0.000
Z98.2 Presence of cerebrospinal fluid drainage device
0.843 0.157 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.841 0.159 0.000
T42.4 Benzodiazepines
0.840 0.160 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.839 0.161 0.000
C67.4 Posterior wall of bladder
0.839 0.161 0.000
X60-X84 Intentional self-harm
0.837 0.162 0.000
Z90 Acquired absence of organs, not elsewhere classified
0.837 0.163 0.000
Z88.8 Personal history of allergy to other drugs, medicaments and biological substances
0.837 0.163 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.831 0.169 0.000
S82.2 Fracture of shaft of tibia
0.830 0.170 0.000
M80 Osteoporosis with pathological fracture
0.829 0.171 0.000
T86 Failure and rejection of transplanted organs and tissues
0.829 0.171 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.828 0.171 0.000
Chapter I Certain infectious and parasitic diseases
0.827 0.173 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.827 0.173 0.000
T43.0 Tricyclic and tetracyclic antidepressants
0.823 0.177 0.000
M47.82 Other spondylosis (Cervical region)
0.823 0.177 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.823 0.177 0.000
Z87.5 Personal history of complications of pregnancy, childbirth and the puerperium
0.820 0.180 0.000
M06.4 Inflammatory polyarthropathy
0.816 0.184 0.000
S20-S29 Injuries to the thorax
0.816 0.184 0.000
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.815 0.185 0.000
M40-M43 Deforming dorsopathies
0.813 0.187 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.812 0.188 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.803 0.197 0.000
C02.1 Border of tongue
0.803 0.197 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.802 0.198 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.801 0.199 0.000
C50.5 Lower-outer quadrant of breast
0.801 0.199 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.801 0.199 0.000
C09 Malignant neoplasm of tonsil
0.800 0.199 0.000
G40-G47 Episodic and paroxysmal disorders
0.800 0.200 0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified
0.799 0.201 0.000
Y40 Systemic antibiotics
0.798 0.202 0.000
M60-M63 Disorders of muscles
0.798 0.202 0.000
Z85.5 Personal history of malignant neoplasm of urinary tract
0.794 0.206 0.000
M06.3 Rheumatoid nodule
0.794 0.206 0.000
C67.2 Lateral wall of bladder
0.792 0.208 0.000
S01.9 Open wound of head, part unspecified
0.792 0.208 0.000
M54 Dorsalgia
0.791 0.209 0.000
Z85.1 Personal history of malignant neoplasm of trachea, bronchus and lung
0.789 0.210 0.000
Z98.1 Arthrodesis status
0.789 0.211 0.000
M50.1 Cervical disk disorder with radiculopathy
0.786 0.214 0.000
M53 Other dorsopathies, not elsewhere classified
0.784 0.215 0.000
Y45.1 Salicylates
0.783 0.217 0.000
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands
0.781 0.219 0.000
T81 Complications of procedures, not elsewhere classified
0.780 0.220 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.780 0.220 0.000
Y00-Y09 Assault
0.780 0.220 0.000
V40-V49 Car occupant injured in transport accident
0.780 0.220 0.000
D40 Neoplasm of uncertain or unknown behaviour of male genital organs
0.780 0.220 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.776 0.223 0.000
G95 Other diseases of spinal cord
0.776 0.224 0.000
T78.2 Anaphylactic shock, unspecified
0.776 0.224 0.000
M47.80 Other spondylosis (Multiple sites in spine)
0.774 0.226 0.000
M00-M03 Infectious arthropathies
0.774 0.226 0.000
Z87.2 Personal history of diseases of the skin and subcutaneous tissue
0.774 0.226 0.000
Z88.4 Personal history of allergy to anaesthetic agent
0.774 0.226 0.000
Y52 Agents primarily affecting the cardiovascular system
0.773 0.226 0.000
M48.02 Spinal stenosis (Cervical region)
0.773 0.227 0.000
M46 Other inflammatory spondylopathies
0.771 0.229 0.000
C07 Malignant neoplasm of parotid gland
0.771 0.229 0.000
T91 Sequelae of injuries of neck and trunk
0.771 0.229 0.000
Y43.3 Other antineoplastic drugs
0.769 0.231 0.000
M51 Other intervertebral disk disorders
0.769 0.231 0.000
M45 Ankylosing spondylitis
0.768 0.232 0.000
Y95 Nosocomial condition
0.768 0.232 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.767 0.232 0.000
M94 Other disorders of cartilage
0.767 0.232 0.000
T81.0 Haemorrhage and haematoma complicating a procedure, not elsewhere classified
0.766 0.234 0.000
G51 Facial nerve disorders
0.765 0.234 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.765 0.235 0.000
Z90.2 Acquired absence of lung [part of]
0.764 0.236 0.000
M84 Disorders of continuity of bone
0.761 0.239 0.000
M14 Arthropathies in other diseases classified elsewhere
0.759 0.241 0.000
C67.5 Bladder neck
0.758 0.242 0.000
Z90.6 Acquired absence of other parts of urinary tract
0.758 0.242 0.000
C49 Malignant neoplasm of other connective and soft tissue
0.757 0.243 0.000
C50.3 Lower-inner quadrant of breast
0.757 0.243 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.757 0.243 0.000
G30-G32 Other degenerative diseases of the nervous system
0.753 0.247 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.752 0.248 0.000
X20-X29 Contact with venomous animals and plants
0.750 0.250 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.750 0.250 0.000
C01 Malignant neoplasm of base of tongue
0.749 0.250 0.000
Z81 Family history of mental and behavioural disorders
0.749 0.251 0.000
T43.3 Phenothiazine antipsychotics and neuroleptics
0.747 0.253 0.000
S82.20 Fracture of shaft of tibia (closed)
0.747 0.253 0.000
M49 Spondylopathies in diseases classified elsewhere
0.747 0.253 0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases
0.747 0.253 0.000
T78.4 Allergy, unspecified
0.746 0.254 0.000
S01.8 Open wound of other parts of head
0.745 0.255 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.743 0.257 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.743 0.257 0.000
M80.9 Unspecified osteoporosis with pathological fracture
0.741 0.259 0.000
M89 Other disorders of bone
0.741 0.259 0.000
Y57 Other and unspecified drugs and medicaments
0.739 0.260 0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs
0.739 0.261 0.000
M47.87 Other spondylosis (Lumbosacral region)
0.737 0.263 0.000
G55 Nerve root and plexus compressions in diseases classified elsewhere
0.736 0.264 0.000
C50.1 Central portion of breast
0.736 0.264 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.736 0.264 0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.735 0.265 0.000
C69 Malignant neoplasm of eye and adnexa
0.735 0.265 0.000
S06 Intracranial injury
0.735 0.265 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.734 0.266 0.000
C79 Secondary malignant neoplasm of other sites
0.733 0.267 0.000
A30-A49 Other bacterial diseases
0.731 0.269 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.731 0.269 0.000
G20-G26 Extrapyramidal and movement disorders
0.730 0.270 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.730 0.270 0.000
M47.2 Other spondylosis with radiculopathy
0.729 0.271 0.000
C71 Malignant neoplasm of brain
0.729 0.271 0.000
Z90.0 Acquired absence of part of head and neck
0.729 0.271 0.000
X62 Intentional self-poisoning by and exposure to narcotics and psychodysleptics [hallucinogens], not elsewhere classified
0.728 0.271 0.000
M48.5 Collapsed vertebra, not elsewhere classified
0.728 0.272 0.000
M50.0 Cervical disk disorder with myelopathy
0.728 0.272 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.725 0.275 0.000
W50-W64 Exposure to animate mechanical forces
0.725 0.275 0.000
M47.89 Other spondylosis (Site unspecified)
0.725 0.275 0.000
Y45.8 Other analgesics and antipyretics
0.725 0.275 0.000
Z97 Presence of other devices
0.723 0.277 0.000
G40 Epilepsy
0.723 0.277 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.722 0.278 0.000
M54.1 Radiculopathy
0.719 0.281 0.000
Z98.8 Other specified postsurgical states
0.719 0.281 0.000
S02 Fracture of skull and facial bones
0.718 0.282 0.000
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
D48.0 Bone and articular cartilage
0.717 0.283 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.717 0.283 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.716 0.283 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.716 0.283 0.000
D41 Neoplasm of uncertain or unknown behaviour of urinary organs
0.716 0.284 0.000
S10 Superficial injury of neck
0.716 0.284 0.000
S05 Injury of eye and orbit
0.716 0.284 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.715 0.285 0.000
M81 Osteoporosis without pathological fracture
0.714 0.286 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.713 0.286 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.713 0.287 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.713 0.287 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.713 0.287 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.713 0.287 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.713 0.287 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.713 0.287 0.000
T36 Poisoning by systemic antibiotics
0.713 0.287 0.000
Z94.7 Corneal transplant status
0.712 0.288 0.000
C66 Malignant neoplasm of ureter
0.711 0.289 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.711 0.289 0.000
C60-C63 Malignant neoplasms of male genital organs
0.711 0.289 0.000
D47.9 Neoplasm of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue, unspecified
0.710 0.290 0.000
T50.9 Other and unspecified drugs, medicaments and biological substances
0.710 0.290 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.710 0.290 0.000
Y35-Y36 Legal intervention and operations of war
0.710 0.290 0.000
Y10-Y34 Event of undetermined intent
0.710 0.290 0.000
X85-X99 Assault
0.710 0.290 0.000
X30-X39 Exposure to forces of nature
0.710 0.290 0.000
X10-X19 Contact with heat and hot substances
0.710 0.290 0.000
X00-X09 Exposure to smoke, fire and flames
0.710 0.290 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.710 0.290 0.000
W75-W84 Other accidental threats to breathing
0.710 0.290 0.000
W65-W74 Accidental drowning and submersion
0.710 0.290 0.000
V98-V99 Other and unspecified transport accidents
0.710 0.290 0.000
V95-V97 Air and space transport accidents
0.710 0.290 0.000
V90-V94 Water transport accidents
0.710 0.290 0.000
V70-V79 Bus occupant injured in transport accident
0.710 0.290 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.710 0.290 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.710 0.290 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.710 0.290 0.000
V01-V09 Pedestrian injured in transport accident
0.710 0.290 0.000
Z94.0 Kidney transplant status
0.709 0.291 0.000
M12 Other specific arthropathies
0.708 0.291 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.708 0.291 0.000
M08 Juvenile arthritis
0.708 0.291 0.000
C68 Malignant neoplasm of other and unspecified urinary organs
0.708 0.292 0.000
C65 Malignant neoplasm of renal pelvis
0.708 0.292 0.000
Chapter XIV Diseases of the genitourinary system
0.708 0.292 0.000
Z87.6 Personal history of certain conditions arising in the perinatal period
0.705 0.295 0.000
Z84 Family history of other conditions
0.705 0.295 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.705 0.295 0.000
M06.8 Other specified rheumatoid arthritis
0.704 0.296 0.000
M06.2 Rheumatoid bursitis
0.704 0.296 0.000
M06.1 Adult-onset Still's disease
0.704 0.296 0.000
Z85.0 Personal history of malignant neoplasm of digestive organs
0.704 0.296 0.000
Z85.9 Personal history of malignant neoplasm, unspecified
0.704 0.296 0.000
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs
0.704 0.296 0.000
M48.9 Spondylopathy, unspecified
0.703 0.296 0.000
M48.8 Other specified spondylopathies
0.703 0.296 0.000
M48.4 Fatigue fracture of vertebra
0.703 0.296 0.000
M48.3 Traumatic spondylopathy
0.703 0.296 0.000
M48.2 Kissing spine
0.703 0.296 0.000
M48.1 Ankylosing hyperostosis [Forestier]
0.703 0.296 0.000
M90 Osteopathies in diseases classified elsewhere
0.703 0.297 0.000
S29 Other and unspecified injuries of thorax
0.703 0.297 0.000
N30-N39 Other diseases of urinary system
0.703 0.297 0.000
M50.9 Cervical disk disorder, unspecified
0.703 0.297 0.000
M50.8 Other cervical disk disorders
0.703 0.297 0.000
D48.5 Skin
0.702 0.298 0.000
V20-V29 Motorcycle rider injured in transport accident
0.702 0.298 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.702 0.298 0.000
X50-X57 Overexertion, travel and privation
0.701 0.299 0.000
Q80-Q89 Other congenital malformations
0.701 0.299 0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.701 0.299 0.000
T45.0 Antiallergic and antiemetic drugs
0.700 0.300 0.000
S81.0 Open wound of knee
0.700 0.300 0.000
S12 Fracture of neck
0.699 0.300 0.000
T80.1 Vascular complications following infusion, transfusion and therapeutic injection
0.699 0.301 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.698 0.301 0.000
D45 Polycythaemia vera
0.698 0.302 0.000
Y45.0 Opioids and related analgesics
0.698 0.302 0.000
S88 Traumatic amputation of lower leg
0.698 0.302 0.000
S87 Crushing injury of lower leg
0.698 0.302 0.000
S86 Injury of muscle and tendon at lower leg level
0.698 0.302 0.000
S85 Injury of blood vessels at lower leg level
0.698 0.302 0.000
S84 Injury of nerves at lower leg level
0.698 0.302 0.000
Y59 Other and unspecified vaccines and biological substances
0.698 0.302 0.000
Y58 Bacterial vaccines
0.698 0.302 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.698 0.302 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.698 0.302 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.698 0.302 0.000
Y48 Anaesthetics and therapeutic gases
0.698 0.302 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.698 0.302 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.698 0.302 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.698 0.302 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.697 0.303 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.697 0.303 0.000
S81.8 Open wound of other parts of lower leg
0.697 0.303 0.000
D42 Neoplasm of uncertain or unknown behaviour of meninges
0.697 0.303 0.000
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.696 0.303 0.000
G57 Mononeuropathies of lower limb
0.696 0.304 0.000
S51 Open wound of forearm
0.695 0.305 0.000
S01.1 Open wound of eyelid and periocular area
0.695 0.305 0.000
S82.5 Fracture of medial malleolus
0.694 0.306 0.000
M48.08 Spinal stenosis (Sacral and sacrococcygeal region)
0.694 0.306 0.000
M48.05 Spinal stenosis (Thoracolumbar region)
0.694 0.306 0.000
M48.04 Spinal stenosis (Thoracic region)
0.694 0.306 0.000
M48.03 Spinal stenosis (Cervicothoracic region)
0.694 0.306 0.000
M48.01 Spinal stenosis (Occipito-atlanto-axial region)
0.694 0.306 0.000
G53 Cranial nerve disorders in diseases classified elsewhere
0.694 0.306 0.000
N35 Urethral stricture
0.694 0.306 0.000
M47.1 Other spondylosis with myelopathy
0.693 0.306 0.000
C67.8 Overlapping lesion of bladder
0.693 0.307 0.000
C67.7 Urachus
0.693 0.307 0.000
C67.3 Anterior wall of bladder
0.693 0.307 0.000
C67.1 Dome of bladder
0.693 0.307 0.000
C67.0 Trigone of bladder
0.693 0.307 0.000
S82.0 Fracture of patella
0.693 0.307 0.000
W00-W19 Falls
0.692 0.308 0.000
S80 Superficial injury of lower leg
0.692 0.308 0.000
G51.0 Bell's palsy
0.692 0.308 0.000
S00 Superficial injury of head
0.691 0.309 0.000
M06.0 Seronegative rheumatoid arthritis
0.691 0.309 0.000
V80-V89 Other land transport accidents
0.690 0.309 0.000
C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx
0.689 0.311 0.000
C13 Malignant neoplasm of hypopharynx
0.689 0.311 0.000
C11 Malignant neoplasm of nasopharynx
0.689 0.311 0.000
C10 Malignant neoplasm of oropharynx
0.689 0.311 0.000
C08 Malignant neoplasm of other and unspecified major salivary glands
0.689 0.311 0.000
C06 Malignant neoplasm of other and unspecified parts of mouth
0.689 0.311 0.000
C05 Malignant neoplasm of palate
0.689 0.311 0.000
C04 Malignant neoplasm of floor of mouth
0.689 0.311 0.000
C03 Malignant neoplasm of gum
0.689 0.311 0.000
C00 Malignant neoplasm of lip
0.689 0.311 0.000
C12 Malignant neoplasm of pyriform sinus
0.689 0.311 0.000
Z94.8 Other transplanted organ and tissue status
0.689 0.311 0.000
S89 Other and unspecified injuries of lower leg
0.689 0.311 0.000
Z85.6 Personal history of leukaemia
0.689 0.311 0.000
N32 Other disorders of bladder
0.688 0.312 0.000
T87 Complications peculiar to reattachment and amputation
0.688 0.312 0.000
M96 Postprocedural musculoskeletal disorders, not elsewhere classified
0.687 0.313 0.000
T78.1 Other adverse food reactions, not elsewhere classified
0.686 0.313 0.000
Z88.9 Personal history of allergy to unspecified drugs, medicaments and biological substances
0.686 0.314 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.686 0.314 0.000
C09.9 Tonsil, unspecified
0.685 0.315 0.000
M92 Other juvenile osteochondrosis
0.685 0.315 0.000
S90-S99 Injuries to the ankle and foot
0.684 0.316 0.000
T98 Sequelae of other and unspecified effects of external causes
0.684 0.316 0.000
Y40.8 Other systemic antibiotics
0.684 0.316 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.682 0.318 0.000
N35.9 Urethral stricture, unspecified
0.682 0.318 0.000
M47.0 Anterior spinal and vertebral artery compression syndromes
0.682 0.318 0.000
T86.1 Kidney transplant failure and rejection
0.682 0.318 0.000
G58 Other mononeuropathies
0.681 0.319 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.681 0.319 0.000
S20 Superficial injury of thorax
0.681 0.319 0.000
G70-G73 Diseases of myoneural junction and muscle
0.680 0.320 0.000
D46 Myelodysplastic syndromes
0.680 0.320 0.000
Y49.2 Other and unspecified antidepressants
0.680 0.320 0.000
M82 Osteoporosis in diseases classified elsewhere
0.679 0.321 0.000
S50 Superficial injury of forearm
0.679 0.321 0.000
Z85.2 Personal history of malignant neoplasm of other respiratory and intrathoracic organs
0.679 0.321 0.000
B35-B49 Mycoses
0.678 0.322 0.000
C02.9 Tongue, unspecified
0.676 0.323 0.000
S19 Other and unspecified injuries of neck
0.676 0.324 0.000
Y45.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.674 0.326 0.000
S82.9 Fracture of lower leg, part unspecified
0.674 0.326 0.000
S82.7 Multiple fractures of lower leg
0.674 0.326 0.000
Y49.5 Other antipsychotics and neuroleptics
0.674 0.326 0.000
T80.2 Infections following infusion, transfusion and therapeutic injection
0.673 0.327 0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants
0.673 0.327 0.000
T42.5 Mixed antiepileptics, not elsewhere classified
0.673 0.327 0.000
T42.3 Barbiturates
0.673 0.327 0.000
T42.2 Succinimides and oxazolidinediones
0.673 0.327 0.000
T42.1 Iminostilbenes
0.673 0.327 0.000
T42.0 Hydantoin derivatives
0.673 0.327 0.000
T86.8 Failure and rejection of other transplanted organs and tissues
0.673 0.327 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.673 0.327 0.000
T68 Hypothermia
0.672 0.328 0.000
S70-S79 Injuries to the hip and thigh
0.670 0.330 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.670 0.330 0.000
S08 Traumatic amputation of part of head
0.670 0.330 0.000
S07 Crushing injury of head
0.670 0.330 0.000
S04 Injury of cranial nerves
0.670 0.330 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.670 0.330 0.000
T78.3 Angioneurotic oedema
0.669 0.331 0.000
T40.2 Other opioids
0.668 0.332 0.000
A41 Other septicaemia
0.667 0.333 0.000
T75 Effects of other external causes
0.667 0.333 0.000
T74 Maltreatment syndromes
0.667 0.333 0.000
T73 Effects of other deprivation
0.667 0.333 0.000
T70 Effects of air pressure and water pressure
0.667 0.333 0.000
T69 Other effects of reduced temperature
0.667 0.333 0.000
T67 Effects of heat and light
0.667 0.333 0.000
T71 Asphyxiation
0.667 0.333 0.000
T66 Unspecified effects of radiation
0.667 0.333 0.000
G91 Hydrocephalus
0.667 0.333 0.000
S60-S69 Injuries to the wrist and hand
0.667 0.333 0.000
M93 Other osteochondropathies
0.666 0.334 0.000
M94.8 Other specified disorders of cartilage
0.665 0.335 0.000
X59 Exposure to unspecified factor
0.665 0.335 0.000
D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs
0.665 0.335 0.000
M83 Adult osteomalacia
0.665 0.335 0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee
0.664 0.336 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.664 0.336 0.000
M48.00 Spinal stenosis (Multiple sites in spine)
0.662 0.338 0.000
D39 Neoplasm of uncertain or unknown behaviour of female genital organs
0.661 0.338 0.000
G95.2 Cord compression, unspecified
0.661 0.339 0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis
0.661 0.339 0.000
S13 Dislocation, sprain and strain of joints and ligaments at neck level
0.659 0.341 0.000
M06.34 Rheumatoid nodule (Hand)
0.659 0.341 0.000
S82.86 Maisonneuve's fracture
0.657 0.342 0.000
S82.81 Fractures of other parts of lower leg (open)
0.657 0.342 0.000
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.658 0.342 0.000
C50.6 Axillary tail of breast
0.657 0.343 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.657 0.343 0.000
Z88.3 Personal history of allergy to other anti-infective agents
0.656 0.344 0.000
S01.4 Open wound of cheek and temporomandibular area
0.655 0.345 0.000
M43 Other deforming dorsopathies
0.655 0.345 0.000
M47.88 Other spondylosis (Sacral and sacrococcygeal region)
0.654 0.346 0.000
M47.85 Other spondylosis (Thoracolumbar region)
0.654 0.346 0.000
M47.84 Other spondylosis (Thoracic region)
0.654 0.346 0.000
M47.83 Other spondylosis (Cervicothoracic region)
0.654 0.346 0.000
M47.81 Other spondylosis (Occipito-atlanto-axial region)
0.654 0.346 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.654 0.346 0.000
M84.1 Nonunion of fracture [pseudarthrosis]
0.654 0.346 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.654 0.346 0.000
Z90.5 Acquired absence of kidney
0.653 0.347 0.000
M62 Other disorders of muscle
0.652 0.347 0.000
T80.8 Other complications following infusion, transfusion and therapeutic injection
0.652 0.348 0.000
Y43.1 Antineoplastic antimetabolites
0.652 0.348 0.000
D48.9 Neoplasms of uncertain or unknown behaviour, unspecified
0.652 0.348 0.000
D48.7 Other specified sites
0.652 0.348 0.000
D48.4 Peritoneum
0.652 0.348 0.000
D48.3 Retroperitoneum
0.652 0.348 0.000
D48.2 Peripheral nerves and autonomic nervous system
0.652 0.348 0.000
M47.9 Spondylosis, unspecified
0.652 0.348 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.651 0.348 0.000
G40.9 Epilepsy, unspecified
0.651 0.349 0.000
T40.4 Other synthetic narcotics
0.651 0.349 0.000
D70 Agranulocytosis
0.651 0.349 0.000
X62.9 Unspecified place
0.650 0.349 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.650 0.350 0.000
Q50-Q56 Congenital malformations of genital organs
0.650 0.350 0.000
G99 Other disorders of nervous system in diseases classified elsewhere
0.650 0.350 0.000
S01.7 Multiple open wounds of head
0.645 0.354 0.000
C78.0 Secondary malignant neoplasm of lung
0.645 0.355 0.000
T43.9 Psychotropic drug, unspecified
0.644 0.355 0.000
T43.8 Other psychotropic drugs, not elsewhere classified
0.644 0.355 0.000
T43.6 Psychostimulants with abuse potential
0.644 0.355 0.000
T43.4 Butyrophenone and thioxanthene neuroleptics
0.644 0.355 0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.644 0.355 0.000
G82 Paraplegia and tetraplegia
0.644 0.356 0.000
D47.2 Monoclonal gammopathy
0.644 0.356 0.000
Y45.9 Analgesic, antipyretic and anti-inflammatory drug, unspecified
0.644 0.356 0.000
Y45.5 4-Aminophenol derivatives
0.644 0.356 0.000
Y45.4 Antirheumatics
0.644 0.356 0.000
Y45.2 Propionic acid derivatives
0.644 0.356 0.000
D44.3 Pituitary gland
0.644 0.356 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.642 0.358 0.000
D40.1 Testis
0.642 0.358 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.642 0.358 0.000
N32.8 Other specified disorders of bladder
0.641 0.359 0.000
S52 Fracture of forearm
0.640 0.360 0.000
A41.5 Septicaemia due to other Gram-negative organisms
0.639 0.361 0.000
T93 Sequelae of injuries of lower limb
0.639 0.361 0.000
M51.0 Lumbar and other intervertebral disk disorders with myelopathy
0.639 0.361 0.000
M85 Other disorders of bone density and structure
0.638 0.362 0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.637 0.363 0.000
S01.5 Open wound of lip and oral cavity
0.637 0.363 0.000
T84.2 Mechanical complication of internal fixation device of other bones
0.636 0.364 0.000
T51 Toxic effect of alcohol
0.636 0.364 0.000
M53.3 Sacrococcygeal disorders, not elsewhere classified
0.635 0.365 0.000
G90 Disorders of autonomic nervous system
0.635 0.365 0.000
M91 Juvenile osteochondrosis of hip and pelvis
0.635 0.365 0.000
T88.4 Failed or difficult intubation
0.634 0.366 0.000
C67.6 Ureteric orifice
0.633 0.367 0.000
D47.1 Chronic myeloproliferative disease
0.633 0.367 0.000
M11 Other crystal arthropathies
0.633 0.367 0.000
C49.3 Connective and soft tissue of thorax
0.633 0.367 0.000
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
0.632 0.368 0.000
T79-T79 Certain early complications of trauma
0.632 0.368 0.000
B15-B19 Viral hepatitis
0.631 0.369 0.000
M54.16 Radiculopathy (Lumbar region)
0.631 0.369 0.000
S17 Crushing injury of neck
0.631 0.369 0.000
S15 Injury of blood vessels at neck level
0.631 0.369 0.000
S14 Injury of nerves and spinal cord at neck level
0.631 0.369 0.000
S11 Open wound of neck
0.631 0.369 0.000
S18 Traumatic amputation at neck level
0.631 0.369 0.000
S16 Injury of muscle and tendon at neck level
0.631 0.369 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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