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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs16976358
log Bayes Factor = 1.04673
Chromosome 18   position 40,191,571  (GRCh37) Explore rs16976358 on Ensembl!
Variant rs16976358 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.904 0.096 0.000
Chapter II Neoplasms
0.900 0.100 0.000
# Top node
0.896 0.104 0.000
M05-M14 Inflammatory polyarthropathies
0.891 0.109 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.884 0.116 0.000
M06 Other rheumatoid arthritis
0.875 0.125 0.000
M20-M25 Other joint disorders
0.870 0.130 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.867 0.133 0.000
M06.9 Rheumatoid arthritis, unspecified
0.864 0.136 0.000
M80-M85 Disorders of bone density and structure
0.856 0.144 0.000
C15-C26 Malignant neoplasms of digestive organs
0.843 0.157 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.837 0.163 0.000
S80-S89 Injuries to the knee and lower leg
0.829 0.171 0.000
C60-C63 Malignant neoplasms of male genital organs
0.827 0.173 0.000
D00-D09 In situ neoplasms
0.807 0.193 0.000
M23 Internal derangement of knee
0.807 0.193 0.000
M81 Osteoporosis without pathological fracture
0.795 0.205 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.790 0.210 0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee
0.784 0.216 0.000
C18 Malignant neoplasm of colon
0.780 0.220 0.000
C61 Malignant neoplasm of prostate
0.776 0.224 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.770 0.230 0.000
O60-O75 Complications of labour and delivery
0.763 0.237 0.000
C43-C44 Melanoma and other malignant neoplasms of skin
0.759 0.241 0.000
D10-D36 Benign neoplasms
0.754 0.246 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.753 0.247 0.000
S83.2 Tear of meniscus, current
0.752 0.248 0.000
M81.9 Osteoporosis, unspecified
0.751 0.249 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.751 0.249 0.000
Chapter VII Diseases of the eye and adnexa
0.746 0.254 0.000
O00-O08 Pregnancy with abortive outcome
0.740 0.260 0.000
S00-S09 Injuries to the head
0.735 0.265 0.000
M23.3 Other meniscus derangements
0.734 0.266 0.000
M25 Other joint disorders, not elsewhere classified
0.734 0.266 0.000
C19 Malignant neoplasm of rectosigmoid junction
0.727 0.273 0.000
M45-M49 Spondylopathies
0.725 0.275 0.000
M24 Other specific joint derangements
0.724 0.276 0.000
M80 Osteoporosis with pathological fracture
0.721 0.279 0.000
M10 Gout
0.717 0.283 0.000
D23 Other benign neoplasms of skin
0.717 0.283 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.714 0.286 0.000
M81.99 Osteoporosis, unspecified (Site unspecified)
0.712 0.288 0.000
S60-S69 Injuries to the wrist and hand
0.708 0.292 0.000
M50-M54 Other dorsopathies
0.704 0.296 0.000
S20-S29 Injuries to the thorax
0.696 0.303 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.692 0.308 0.000
M07 Psoriatic and enteropathic arthropathies
0.692 0.308 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.692 0.308 0.000
D05 Carcinoma in situ of breast
0.690 0.310 0.000
Chapter XXII Codes for special purposes
0.687 0.313 0.000
M22 Disorders of patella
0.687 0.313 0.000
Chapter VI Diseases of the nervous system
0.683 0.317 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.677 0.323 0.000
Chapter VIII Diseases of the ear and mastoid process
0.677 0.323 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.672 0.328 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.668 0.332 0.000
Chapter I Certain infectious and parasitic diseases
0.668 0.332 0.000
M40-M43 Deforming dorsopathies
0.666 0.334 0.000
M31 Other necrotising vasculopathies
0.665 0.335 0.000
C51-C58 Malignant neoplasms of female genital organs
0.661 0.339 0.000
C25 Malignant neoplasm of pancreas
0.660 0.340 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.659 0.341 0.000
O02 Other abnormal products of conception
0.653 0.347 0.000
C18.0 Caecum
0.652 0.348 0.000
O48 Prolonged pregnancy
0.649 0.351 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.648 0.352 0.000
M91-M94 Chondropathies
0.648 0.352 0.000
M86-M90 Other osteopathies
0.648 0.352 0.000
M60-M63 Disorders of muscles
0.648 0.352 0.000
M00-M03 Infectious arthropathies
0.648 0.352 0.000
C18.9 Colon, unspecified
0.647 0.353 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.645 0.355 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.645 0.355 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.645 0.355 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.645 0.355 0.000
T66-T78 Other and unspecified effects of external causes
0.644 0.356 0.000
C90 Multiple myeloma and malignant plasma cell neoplasms
0.644 0.356 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.643 0.357 0.000
D03 Melanoma in situ
0.643 0.357 0.000
M23.8 Other internal derangements of knee
0.642 0.358 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.642 0.358 0.000
S40-S49 Injuries to the shoulder and upper arm
0.640 0.360 0.000
M35 Other systemic involvement of connective tissue
0.640 0.360 0.000
S01 Open wound of head
0.639 0.360 0.000
M14 Arthropathies in other diseases classified elsewhere
0.639 0.361 0.000
M12 Other specific arthropathies
0.639 0.361 0.000
M11 Other crystal arthropathies
0.639 0.361 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.639 0.361 0.000
M08 Juvenile arthritis
0.639 0.361 0.000
M05 Seropositive rheumatoid arthritis
0.639 0.361 0.000
M13 Other arthritis
0.638 0.362 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.636 0.364 0.000
O34 Maternal care for known or suspected abnormality of pelvic organs
0.635 0.365 0.000
M25.7 Osteophyte
0.635 0.365 0.000
O68 Labour and delivery complicated by foetal stress [distress]
0.635 0.365 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.634 0.366 0.000
T79-T79 Certain early complications of trauma
0.634 0.366 0.000
T33-T35 Frostbite
0.634 0.366 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.634 0.366 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.634 0.366 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.634 0.366 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.634 0.366 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.634 0.366 0.000
T00-T07 Injuries involving multiple body regions
0.634 0.366 0.000
S90-S99 Injuries to the ankle and foot
0.634 0.366 0.000
S10-S19 Injuries to the neck
0.634 0.366 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.630 0.370 0.000
M23.32 Other meniscus derangements (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.630 0.370 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.630 0.370 0.000
C18.7 Sigmoid colon
0.629 0.371 0.000
O72 Postpartum haemorrhage
0.629 0.371 0.000
S50-S59 Injuries to the elbow and forearm
0.628 0.371 0.000
M06.8 Other specified rheumatoid arthritis
0.627 0.372 0.000
M06.4 Inflammatory polyarthropathy
0.627 0.372 0.000
M06.3 Rheumatoid nodule
0.627 0.372 0.000
M06.2 Rheumatoid bursitis
0.627 0.372 0.000
M06.1 Adult-onset Still's disease
0.627 0.372 0.000
M06.0 Seronegative rheumatoid arthritis
0.627 0.372 0.000
M80.9 Unspecified osteoporosis with pathological fracture
0.625 0.375 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.624 0.376 0.000
M34 Systemic sclerosis
0.624 0.376 0.000
M33 Dermatopolymyositis
0.624 0.376 0.000
M32 Systemic lupus erythematosus
0.624 0.376 0.000
M30 Polyarteritis nodosa and related conditions
0.624 0.376 0.000
M21 Other acquired deformities of limbs
0.624 0.376 0.000
M23.4 Loose body in knee
0.623 0.377 0.000
D27 Benign neoplasm of ovary
0.622 0.378 0.000
O85-O92 Complications predominantly related to the puerperium
0.622 0.378 0.000
M65-M68 Disorders of synovium and tendon
0.620 0.380 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.619 0.380 0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.619 0.380 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.619 0.380 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.619 0.380 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.619 0.380 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.619 0.380 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.619 0.380 0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.619 0.380 0.000
D23.5 Skin of trunk
0.619 0.381 0.000
M24.1 Other articular cartilage disorders
0.619 0.381 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.617 0.383 0.000
D11 Benign neoplasm of major salivary glands
0.616 0.384 0.000
M85 Other disorders of bone density and structure
0.614 0.386 0.000
M84 Disorders of continuity of bone
0.614 0.386 0.000
M83 Adult osteomalacia
0.614 0.386 0.000
M82 Osteoporosis in diseases classified elsewhere
0.614 0.386 0.000
C43 Malignant melanoma of skin
0.613 0.386 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.613 0.387 0.000
S82 Fracture of lower leg, including ankle
0.612 0.388 0.000
C44 Other malignant neoplasms of skin
0.611 0.389 0.000
D23.1 Skin of eyelid, including canthus
0.610 0.390 0.000
O36 Maternal care for other known or suspected foetal problems
0.608 0.392 0.000
S80 Superficial injury of lower leg
0.608 0.392 0.000
D06 Carcinoma in situ of cervix uteri
0.607 0.393 0.000
H10-H13 Disorders of conjunctiva
0.605 0.395 0.000
D07 Carcinoma in situ of other and unspecified genital organs
0.604 0.396 0.000
C26 Malignant neoplasm of other and ill-defined digestive organs
0.604 0.396 0.000
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.604 0.396 0.000
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.604 0.396 0.000
C21 Malignant neoplasm of anus and anal canal
0.604 0.396 0.000
C17 Malignant neoplasm of small intestine
0.604 0.396 0.000
C16 Malignant neoplasm of stomach
0.604 0.396 0.000
C15 Malignant neoplasm of oesophagus
0.604 0.396 0.000
C23 Malignant neoplasm of gallbladder
0.604 0.396 0.000
H53-H54 Visual disturbances and blindness
0.604 0.396 0.000
D05.1 Intraductal carcinoma in situ
0.603 0.397 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.600 0.400 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.597 0.402 0.000
S89 Other and unspecified injuries of lower leg
0.595 0.405 0.000
S88 Traumatic amputation of lower leg
0.595 0.405 0.000
S87 Crushing injury of lower leg
0.595 0.405 0.000
S86 Injury of muscle and tendon at lower leg level
0.595 0.405 0.000
S85 Injury of blood vessels at lower leg level
0.595 0.405 0.000
S84 Injury of nerves at lower leg level
0.595 0.405 0.000
S81 Open wound of lower leg
0.595 0.405 0.000
C18.2 Ascending colon
0.594 0.406 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.593 0.407 0.000
C63 Malignant neoplasm of other and unspecified male genital organs
0.593 0.407 0.000
C62 Malignant neoplasm of testis
0.593 0.407 0.000
C60 Malignant neoplasm of penis
0.593 0.407 0.000
M10.9 Gout, unspecified
0.592 0.408 0.000
O02.1 Missed abortion
0.591 0.409 0.000
T81 Complications of procedures, not elsewhere classified
0.591 0.409 0.000
O63 Long labour
0.591 0.409 0.000
D23.9 Skin, unspecified
0.589 0.411 0.000
O69 Labour and delivery complicated by umbilical cord complications
0.588 0.412 0.000
H40-H42 Glaucoma
0.588 0.412 0.000
O80-O84 Delivery
0.587 0.412 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.587 0.413 0.000
S70-S79 Injuries to the hip and thigh
0.585 0.414 0.000
D13 Benign neoplasm of other and ill-defined parts of digestive system
0.585 0.414 0.000
M81.90 Osteoporosis, unspecified (Multiple sites)
0.579 0.421 0.000
S02 Fracture of skull and facial bones
0.579 0.421 0.000
D09 Carcinoma in situ of other and unspecified sites
0.579 0.421 0.000
D04 Carcinoma in situ of skin
0.579 0.421 0.000
D02 Carcinoma in situ of middle ear and respiratory system
0.579 0.421 0.000
D01 Carcinoma in situ of other and unspecified digestive organs
0.579 0.421 0.000
D00 Carcinoma in situ of oral cavity, oesophagus and stomach
0.579 0.421 0.000
M23.9 Internal derangement of knee, unspecified
0.579 0.421 0.000
M23.6 Other spontaneous disruption of ligament(s) of knee
0.579 0.421 0.000
M23.5 Chronic instability of knee
0.579 0.421 0.000
M23.1 Discoid meniscus (congenital)
0.579 0.421 0.000
M23.0 Cystic meniscus
0.579 0.421 0.000
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)
0.577 0.422 0.000
S66 Injury of muscle and tendon at wrist and hand level
0.576 0.424 0.000
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.575 0.425 0.000
M25.5 Pain in joint
0.572 0.428 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.571 0.429 0.000
M81.8 Other osteoporosis
0.570 0.430 0.000
M81.6 Localised osteoporosis [Lequesne]
0.570 0.430 0.000
M81.5 Idiopathic osteoporosis
0.570 0.430 0.000
M81.4 Drug-induced osteoporosis
0.570 0.430 0.000
M81.3 Postsurgical malabsorption osteoporosis
0.570 0.430 0.000
M81.2 Osteoporosis of disuse
0.570 0.430 0.000
M81.1 Postoophorectomy osteoporosis
0.570 0.430 0.000
M81.0 Postmenopausal osteoporosis
0.570 0.430 0.000
C50-C50 Malignant neoplasm of breast
0.568 0.431 0.000
M23.30 Other meniscus derangements (Multiple sites)
0.567 0.433 0.000
C44.7 Skin of lower limb, including hip
0.566 0.434 0.000
M50 Cervical disk disorders
0.566 0.434 0.000
C90.0 Multiple myeloma
0.565 0.435 0.000
M23.2 Derangement of meniscus due to old tear or injury
0.564 0.436 0.000
D24 Benign neoplasm of breast
0.564 0.436 0.000
E00-E07 Disorders of thyroid gland
0.563 0.436 0.000
C64-C68 Malignant neoplasms of urinary tract
0.562 0.437 0.000
S83.7 Injury to multiple structures of knee
0.562 0.438 0.000
S83.6 Sprain and strain of other and unspecified parts of knee
0.562 0.438 0.000
S83.5 Sprain and strain involving (anterior)(posterior) cruciate ligament of knee
0.562 0.438 0.000
S83.4 Sprain and strain involving (fibular)(tibial) collateral ligamnent of knee
0.562 0.438 0.000
S83.3 Tear of articular cartilage of knee, current
0.562 0.438 0.000
S83.1 Dislocation of knee
0.562 0.438 0.000
S83.0 Dislocation of patella
0.562 0.438 0.000
M23.36 Other meniscus derangements (Other and unspecified lateral meniscus)
0.562 0.438 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.561 0.439 0.000
C18.8 Overlapping lesion of colon
0.559 0.440 0.000
C18.6 Descending colon
0.559 0.440 0.000
C18.5 Splenic flexure
0.559 0.440 0.000
C18.4 Transverse colon
0.559 0.440 0.000
C18.3 Hepatic flexure
0.559 0.440 0.000
C18.1 Appendix
0.559 0.440 0.000
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.559 0.441 0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.559 0.441 0.000
D18 Haemangioma and lymphangioma, any site
0.559 0.441 0.000
M22.4 Chondromalacia patellae
0.556 0.444 0.000
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs
0.554 0.446 0.000
O46 Antepartum haemorrhage, not elsewhere classified
0.553 0.447 0.000
S00 Superficial injury of head
0.553 0.447 0.000
M47 Spondylosis
0.553 0.447 0.000
O45 Premature separation of placenta [abruptio placentae]
0.552 0.448 0.000
O44 Placenta praevia
0.552 0.448 0.000
O43 Placental disorders
0.552 0.448 0.000
O42 Premature rupture of membranes
0.552 0.448 0.000
O41 Other disorders of amniotic fluid and membranes
0.552 0.448 0.000
O35 Maternal care for known or suspected foetal abnormality and damage
0.552 0.448 0.000
O33 Maternal care for known or suspected disproportion
0.552 0.448 0.000
O32 Maternal care for known or suspected malpresentation of foetus
0.552 0.448 0.000
O31 Complications specific to multiple gestation
0.552 0.448 0.000
O30 Multiple gestation
0.552 0.448 0.000
O40 Polyhydramnios
0.552 0.448 0.000
S22 Fracture of rib(s), sternum and thoracic spine
0.549 0.451 0.000
M07.3 Other psoriatic arthropathies
0.549 0.451 0.000
M46 Other inflammatory spondylopathies
0.549 0.451 0.000
D23.6 Skin of upper limb, including shoulder
0.548 0.452 0.000
D32 Benign neoplasm of meninges
0.548 0.452 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.548 0.452 0.000
M25.76 Osteophyte (Lower leg)
0.548 0.452 0.000
O75 Other complications of labour and delivery, not elsewhere classified
0.547 0.453 0.000
O74 Complications of anaesthesia during labour and delivery
0.547 0.453 0.000
O73 Retained placenta and membranes, without haemorrhage
0.547 0.453 0.000
O71 Other obstetric trauma
0.547 0.453 0.000
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified
0.547 0.453 0.000
O66 Other obstructed labour
0.547 0.453 0.000
O65 Obstructed labour due to maternal pelvic abnormality
0.547 0.453 0.000
O64 Obstructed labour due to malposition and malpresentation of foetus
0.547 0.453 0.000
O62 Abnormalities of forces of labour
0.547 0.453 0.000
O61 Failed induction of labour
0.547 0.453 0.000
O60 Preterm delivery
0.547 0.453 0.000
H02 Other disorders of eyelid
0.547 0.453 0.000
M48 Other spondylopathies
0.546 0.454 0.000
D35 Benign neoplasm of other and unspecified endocrine glands
0.545 0.455 0.000
M24.16 Other articular cartilage disorders (Lower leg)
0.544 0.456 0.000
C73 Malignant neoplasm of thyroid gland
0.544 0.456 0.000
C45 Mesothelioma
0.543 0.457 0.000
O03 Spontaneous abortion
0.542 0.458 0.000
S01.3 Open wound of ear
0.542 0.458 0.000
E03 Other hypothyroidism
0.541 0.458 0.000
M25.56 Pain in joint (Lower leg)
0.541 0.459 0.000
D33 Benign neoplasm of brain and other parts of central nervous system
0.541 0.459 0.000
D31 Benign neoplasm of eye and adnexa
0.541 0.459 0.000
D30 Benign neoplasm of urinary organs
0.541 0.459 0.000
D29 Benign neoplasm of male genital organs
0.541 0.459 0.000
D28 Benign neoplasm of other and unspecified female genital organs
0.541 0.459 0.000
D26 Other benign neoplasms of uterus
0.541 0.459 0.000
D21 Other benign neoplasms of connective and other soft tissue
0.541 0.459 0.000
D20 Benign neoplasm of soft tissue of retroperitoneum and peritoneum
0.541 0.459 0.000
D19 Benign neoplasm of mesothelial tissue
0.541 0.459 0.000
D16 Benign neoplasm of bone and articular cartilage
0.541 0.459 0.000
D15 Benign neoplasm of other and unspecified intrathoracic organs
0.541 0.459 0.000
D14 Benign neoplasm of middle ear and respiratory system
0.541 0.459 0.000
D10 Benign neoplasm of mouth and pharynx
0.541 0.459 0.000
D34 Benign neoplasm of thyroid gland
0.541 0.459 0.000
H90-H95 Other disorders of ear
0.541 0.459 0.000
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.540 0.460 0.000
C95 Leukaemia of unspecified cell type
0.540 0.460 0.000
C94 Other leukaemias of specified cell type
0.540 0.460 0.000
C93 Monocytic leukaemia
0.540 0.460 0.000
C92 Myeloid leukaemia
0.540 0.460 0.000
C88 Malignant immunoproliferative diseases
0.540 0.460 0.000
C86 Other specified types of T/NK-cell lymphoma
0.540 0.460 0.000
C84 Peripheral and cutaneous T-cell lymphomas
0.540 0.460 0.000
C81 Hodgkin's disease
0.540 0.460 0.000
S62 Fracture at wrist and hand level
0.540 0.460 0.000
S01.5 Open wound of lip and oral cavity
0.540 0.460 0.000
O34.2 Maternal care due to uterine scar from previous surgery
0.539 0.461 0.000
C83 Diffuse non-Hodgkin's lymphoma
0.539 0.461 0.000
M81.98 Osteoporosis, unspecified (Other)
0.538 0.461 0.000
M81.97 Osteoporosis, unspecified (Ankle and foot)
0.538 0.461 0.000
M81.96 Osteoporosis, unspecified (Lower leg)
0.538 0.461 0.000
M81.95 Osteoporosis, unspecified (Pelvic region and thigh)
0.538 0.461 0.000
M81.94 Osteoporosis, unspecified (Hand)
0.538 0.461 0.000
M81.93 Osteoporosis, unspecified (Forearm)
0.538 0.461 0.000
M81.92 Osteoporosis, unspecified (Upper arm)
0.538 0.461 0.000
M81.91 Osteoporosis, unspecified (Shoulder region)
0.538 0.461 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.538 0.461 0.000
T87 Complications peculiar to reattachment and amputation
0.538 0.461 0.000
T86 Failure and rejection of transplanted organs and tissues
0.538 0.461 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.538 0.461 0.000
H43-H45 Disorders of vitreous body and globe
0.537 0.463 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.537 0.463 0.000
H55-H59 Other disorders of eye and adnexa
0.535 0.465 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.535 0.465 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.535 0.465 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.534 0.466 0.000
D36 Benign neoplasm of other and unspecified sites
0.534 0.466 0.000
D22 Melanocytic naevi
0.532 0.468 0.000
Chapter V Mental and behavioural disorders
0.531 0.469 0.000
O08 Complications following abortion and ectopic and molar pregnancy
0.531 0.469 0.000
O07 Failed attempted abortion
0.531 0.469 0.000
O06 Unspecified abortion
0.531 0.469 0.000
O05 Other abortion
0.531 0.469 0.000
O01 Hydatidiform mole
0.531 0.469 0.000
O00 Ectopic pregnancy
0.531 0.469 0.000
C25.9 Pancreas, unspecified
0.529 0.470 0.000
S32 Fracture of lumbar spine and pelvis
0.529 0.471 0.000
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)
0.527 0.473 0.000
S08 Traumatic amputation of part of head
0.527 0.473 0.000
S07 Crushing injury of head
0.527 0.473 0.000
S06 Intracranial injury
0.527 0.473 0.000
S05 Injury of eye and orbit
0.527 0.473 0.000
S04 Injury of cranial nerves
0.527 0.473 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.527 0.473 0.000
M23.39 Other meniscus derangements (Unspecified ligament or Unspecified meniscus)
0.526 0.474 0.000
M23.37 Other meniscus derangements-Capsular lig
0.526 0.474 0.000
M23.35 Other meniscus derangements (Posterior horn of lateral meniscus)
0.526 0.474 0.000
M23.34 Other meniscus derangements (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.526 0.474 0.000
M23.31 Other meniscus derangements (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.526 0.474 0.000
M25.9 Joint disorder, unspecified
0.526 0.474 0.000
M25.8 Other specified joint disorders
0.526 0.474 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.526 0.474 0.000
M25.3 Other instability of joint
0.526 0.474 0.000
M25.2 Flail joint
0.526 0.474 0.000
M25.1 Fistula of joint
0.526 0.474 0.000
M25.0 Haemarthrosis
0.526 0.474 0.000
E03.9 Hypothyroidism, unspecified
0.526 0.474 0.000
D03.3 Melanoma in situ of other and unspecified parts of face
0.525 0.475 0.000
G20-G26 Extrapyramidal and movement disorders
0.522 0.478 0.000
M23.81 Other internal derangements of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.522 0.478 0.000
C54 Malignant neoplasm of corpus uteri
0.520 0.479 0.000
M49 Spondylopathies in diseases classified elsewhere
0.519 0.480 0.000
M45 Ankylosing spondylitis
0.519 0.480 0.000
M15-M19 Arthrosis
0.519 0.481 0.000
M24.9 Joint derangement, unspecified
0.519 0.481 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.519 0.481 0.000
M24.7 Protrusio acetabuli
0.519 0.481 0.000
M24.6 Ankylosis of joint
0.519 0.481 0.000
M24.5 Contracture of joint
0.519 0.481 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.519 0.481 0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified
0.519 0.481 0.000
M24.2 Disorder of ligament
0.519 0.481 0.000
M24.0 Loose body in joint
0.519 0.481 0.000
O72.0 Third-stage haemorrhage
0.519 0.481 0.000
M31.6 Other giant cell arteritis
0.519 0.481 0.000
S01.2 Open wound of nose
0.519 0.481 0.000
A00-A09 Intestinal infectious diseases
0.517 0.482 0.000
G90-G99 Other disorders of the nervous system
0.517 0.483 0.000
M80.8 Other osteoporosis with pathological fracture
0.517 0.483 0.000
M80.5 Idiopathic osteoporosis with pathological fracture
0.517 0.483 0.000
M80.4 Drug-induced osteoporosis with pathological fracture
0.517 0.483 0.000
M80.3 Postsurgical malabsorption osteoporosis with pathological fracture
0.517 0.483 0.000
M80.2 Osteoporosis of disuse with pathological fracture
0.517 0.483 0.000
M80.1 Postoophorectomy osteoporosis with pathological fracture
0.517 0.483 0.000
M80.0 Postmenopausal osteoporosis with pathological fracture
0.517 0.483 0.000
O68.9 Labour and delivery complicated by foetal stress, unspecified
0.517 0.483 0.000
D11.0 Parotid gland
0.517 0.483 0.000
S27 Injury of other and unspecified intrathoracic organs
0.516 0.483 0.000
M54 Dorsalgia
0.516 0.484 0.000
M10.4 Other secondary gout
0.514 0.486 0.000
M10.3 Gout due to impairment of renal function
0.514 0.486 0.000
M10.2 Drug-induced gout
0.514 0.486 0.000
M10.1 Lead-induced gout
0.514 0.486 0.000
M10.0 Idiopathic gout
0.514 0.486 0.000
D23.7 Skin of lower limb, including hip
0.514 0.486 0.000
D23.4 Skin of scalp and neck
0.514 0.486 0.000
D23.3 Skin of other and unspecified parts of face
0.514 0.486 0.000
D23.2 Skin of ear and external auricular canal
0.514 0.486 0.000
D23.0 Skin of lip
0.514 0.486 0.000
A30-A49 Other bacterial diseases
0.514 0.486 0.000
S68 Traumatic amputation of wrist and hand
0.513 0.487 0.000
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites
0.512 0.488 0.000
D46 Myelodysplastic syndromes
0.512 0.488 0.000
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands
0.512 0.488 0.000
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system
0.512 0.488 0.000
D42 Neoplasm of uncertain or unknown behaviour of meninges
0.512 0.488 0.000
D40 Neoplasm of uncertain or unknown behaviour of male genital organs
0.512 0.488 0.000
D39 Neoplasm of uncertain or unknown behaviour of female genital organs
0.512 0.488 0.000
D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs
0.512 0.488 0.000
D45 Polycythaemia vera
0.512 0.488 0.000
C91 Lymphoid leukaemia
0.510 0.489 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.510 0.490 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.509 0.490 0.000
C34 Malignant neoplasm of bronchus and lung
0.509 0.491 0.000
O04 Medical abortion
0.508 0.491 0.000
C43.9 Malignant melanoma of skin, unspecified
0.507 0.492 0.000
S69 Other and unspecified injuries of wrist and hand
0.507 0.492 0.000
S67 Crushing injury of wrist and hand
0.507 0.492 0.000
S65 Injury of blood vessels at wrist and hand level
0.507 0.492 0.000
S64 Injury of nerves at wrist and hand level
0.507 0.492 0.000
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level
0.507 0.492 0.000
S60 Superficial injury of wrist and hand
0.507 0.492 0.000
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
0.506 0.494 0.000
M53 Other dorsopathies, not elsewhere classified
0.505 0.495 0.000
O26 Maternal care for other conditions predominantly related to pregnancy
0.504 0.496 0.000
T81.4 Infection following a procedure, not elsewhere classified
0.504 0.496 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.504 0.496 0.000
H11 Other disorders of conjunctiva
0.504 0.496 0.000
M23.22 Derangement of meniscus due to old tear or injury (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.503 0.497 0.000
M10.99 Gout, unspecified (Site unspecified)
0.503 0.497 0.000
T81.0 Haemorrhage and haematoma complicating a procedure, not elsewhere classified
0.502 0.498 0.000
G55 Nerve root and plexus compressions in diseases classified elsewhere
0.500 0.500 0.000
M80.98 Unspecified osteoporosis with pathological fracture (Other)
0.500 0.500 0.000
S29 Other and unspecified injuries of thorax
0.499 0.500 0.000
S28 Crushing injury of thorax and traumatic amputation of part of thorax
0.499 0.500 0.000
S26 Injury of heart
0.499 0.500 0.000
S25 Injury of blood vessels of thorax
0.499 0.500 0.000
S24 Injury of nerves and spinal cord at thorax level
0.499 0.500 0.000
S23 Dislocation, sprain and strain of joints and ligaments of thorax
0.499 0.500 0.000
S21 Open wound of thorax
0.499 0.500 0.000
S20 Superficial injury of thorax
0.499 0.500 0.000
D05.9 Carcinoma in situ of breast, unspecified
0.499 0.501 0.000
O68.8 Labour and delivery complicated by other evidence of foetal stress
0.499 0.501 0.000
C75 Malignant neoplasm of other endocrine glands and related structures
0.496 0.503 0.000
C74 Malignant neoplasm of adrenal gland
0.496 0.503 0.000
B35-B49 Mycoses
0.496 0.504 0.000
M07.6 Other enteropathic arthropathies
0.496 0.504 0.000
M07.5 Arthropathy in ulcerative colitis
0.496 0.504 0.000
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.496 0.504 0.000
M07.2 Psoriatic spondylitis
0.496 0.504 0.000
M07.1 Arthritis mutilans
0.496 0.504 0.000
M07.0 Distal interphalangeal psoriatic arthropathy
0.496 0.504 0.000
C49 Malignant neoplasm of other connective and soft tissue
0.496 0.504 0.000
C48 Malignant neoplasm of retroperitoneum and peritoneum
0.496 0.504 0.000
C47 Malignant neoplasm of peripheral nerves and autonomic nervous system
0.496 0.504 0.000
C46 Kaposi's sarcoma
0.496 0.504 0.000
M41 Scoliosis
0.495 0.505 0.000
D05.7 Other carcinoma in situ of breast
0.494 0.505 0.000
D05.0 Lobular carcinoma in situ
0.494 0.505 0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs
0.493 0.507 0.000
M22.1 Recurrent subluxation of patella
0.492 0.507 0.000
M22.9 Disorder of patella, unspecified
0.492 0.507 0.000
M22.8 Other disorders of patella
0.492 0.507 0.000
M22.3 Other derangements of patella
0.492 0.507 0.000
M22.2 Patellofemoral disorders
0.492 0.507 0.000
M22.0 Recurrent dislocation of patella
0.492 0.507 0.000
O36.8 Maternal care for other specified foetal problems
0.493 0.507 0.000
O47 False labour
0.492 0.507 0.000
T83.5 Infection and inflammatory reaction due to prosthetic device, implant and graft in urinary system
0.492 0.508 0.000
G35 Multiple sclerosis
0.491 0.509 0.000
M23.49 Loose body in knee-Unspec lig/men
0.491 0.509 0.000
G70-G73 Diseases of myoneural junction and muscle
0.489 0.510 0.000
G30-G32 Other degenerative diseases of the nervous system
0.489 0.510 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.489 0.510 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.489 0.510 0.000
H65-H75 Diseases of middle ear and mastoid
0.487 0.513 0.000
T85.6 Mechanical complication of other specified internal prosthetic devices, implants and grafts
0.487 0.513 0.000
M51 Other intervertebral disk disorders
0.486 0.514 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.486 0.514 0.000
S39 Other and unspecified injuries of abdomen, lower back and pelvis
0.486 0.514 0.000
S38 Crushing injury and traumatic amputation of part of abdomen, lower back and pelvis
0.486 0.514 0.000
S37 Injury of urinary and pelvic organs
0.486 0.514 0.000
S36 Injury of intra-abdominal organs
0.486 0.514 0.000
S35 Injury of blood vessels at abdomen, lower back and pelvis level
0.486 0.514 0.000
S34 Injury of nerves and lumbar spinal cord at abdomen, lower back and pelvis level
0.486 0.514 0.000
S33 Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis
0.486 0.514 0.000
S31 Open wound of abdomen, lower back and pelvis
0.486 0.514 0.000
S30 Superficial injury of abdomen, lower back and pelvis
0.486 0.514 0.000
H60-H62 Diseases of external ear
0.485 0.514 0.000
M25.75 Osteophyte (Pelvic region and thigh)
0.483 0.517 0.000
C39 Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs
0.482 0.518 0.000
C38 Malignant neoplasm of heart, mediastinum and pleura
0.482 0.518 0.000
C32 Malignant neoplasm of larynx
0.482 0.518 0.000
C31 Malignant neoplasm of accessory sinuses
0.482 0.518 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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