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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs17722134
log Bayes Factor = 13.8489
Chromosome 12   position 72,401,694  (GRCh37) Explore rs17722134 on Ensembl!
Variant rs17722134 is part of Cluster X0080

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
Chapter VI Diseases of the nervous system
1.000 0.000 0.000
Chapter XX External causes of morbidity and mortality
1.000 0.000 0.000
G40-G47 Episodic and paroxysmal disorders
0.998 0.002 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.998 0.002 0.000
G40 Epilepsy
0.998 0.002 0.000
M20-M25 Other joint disorders
0.995 0.005 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.992 0.008 0.000
Chapter IX Diseases of the circulatory system
0.989 0.011 0.000
M70-M79 Other soft tissue disorders
0.987 0.013 0.000
M50-M54 Other dorsopathies
0.986 0.014 0.000
G90-G99 Other disorders of the nervous system
0.985 0.015 0.000
M25 Other joint disorders, not elsewhere classified
0.981 0.019 0.000
M54 Dorsalgia
0.980 0.020 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.977 0.023 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.973 0.027 0.000
G40.9 Epilepsy, unspecified
0.966 0.034 0.000
M54.5 Low back pain
0.965 0.035 0.000
M65-M68 Disorders of synovium and tendon
0.961 0.039 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.954 0.046 0.000
G40.3 Generalised idiopathic epilepsy and epileptic syndromes
0.950 0.050 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.950 0.050 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.943 0.057 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.943 0.057 0.000
S00-S09 Injuries to the head
0.940 0.060 0.000
Y52 Agents primarily affecting the cardiovascular system
0.939 0.061 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.939 0.061 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.937 0.063 0.000
G93 Other disorders of brain
0.936 0.064 0.000
T90 Sequelae of injuries of head
0.935 0.065 0.000
E70-E90 Metabolic disorders
0.918 0.082 0.000
G91 Hydrocephalus
0.918 0.082 0.000
S20-S29 Injuries to the thorax
0.915 0.085 0.000
I27 Other pulmonary heart diseases
0.914 0.086 0.000
X60-X84 Intentional self-harm
0.911 0.089 0.000
I71 Aortic aneurysm and dissection
0.910 0.090 0.000
Y57 Other and unspecified drugs and medicaments
0.906 0.094 0.000
M24 Other specific joint derangements
0.904 0.096 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.903 0.097 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.902 0.098 0.000
S60-S69 Injuries to the wrist and hand
0.896 0.104 0.000
M54.58 Low back pain (Sacral and sacrococcygeal region)
0.894 0.106 0.000
G40.5 Special epileptic syndromes
0.887 0.113 0.000
M15-M19 Arthrosis
0.884 0.116 0.000
I60-I69 Cerebrovascular diseases
0.883 0.117 0.000
E86 Volume depletion
0.879 0.121 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.878 0.122 0.000
M21 Other acquired deformities of limbs
0.878 0.122 0.000
M25.7 Osteophyte
0.877 0.123 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.877 0.123 0.000
S40-S49 Injuries to the shoulder and upper arm
0.876 0.124 0.000
T90.2 Sequelae of fracture of skull and facial bones
0.873 0.127 0.000
G20-G26 Extrapyramidal and movement disorders
0.873 0.127 0.000
Y43 Primarily systemic agents
0.872 0.128 0.000
M25.4 Effusion of joint
0.866 0.134 0.000
M65 Synovitis and tenosynovitis
0.866 0.134 0.000
M77 Other enthesopathies
0.865 0.135 0.000
G40.6 Grand mal seizures, unspecified (with or without petit mal)
0.864 0.136 0.000
G91.9 Hydrocephalus, unspecified
0.859 0.141 0.000
G30-G32 Other degenerative diseases of the nervous system
0.859 0.141 0.000
E20-E35 Disorders of other endocrine glands
0.858 0.142 0.000
Y44 Agents primarily affecting blood constituents
0.855 0.145 0.000
M54.56 Low back pain (Lumbar region)
0.855 0.145 0.000
M67 Other disorders of synovium and tendon
0.854 0.146 0.000
I27.0 Primary pulmonary hypertension
0.853 0.147 0.000
S02 Fracture of skull and facial bones
0.851 0.149 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.850 0.150 0.000
M54.9 Dorsalgia, unspecified
0.848 0.152 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.848 0.152 0.000
S22 Fracture of rib(s), sternum and thoracic spine
0.847 0.153 0.000
T43.2 Other and unspecified antidepressants
0.846 0.154 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.846 0.154 0.000
G93.4 Encephalopathy, unspecified
0.845 0.155 0.000
Y86 Sequelae of other accidents
0.844 0.156 0.000
S00 Superficial injury of head
0.844 0.156 0.000
M60-M63 Disorders of muscles
0.843 0.157 0.000
S90-S99 Injuries to the ankle and foot
0.842 0.158 0.000
M79.6 Pain in limb
0.842 0.158 0.000
M25.3 Other instability of joint
0.841 0.159 0.000
I74 Arterial embolism and thrombosis
0.840 0.160 0.000
I69 Sequelae of cerebrovascular disease
0.839 0.161 0.000
E87.1 Hypo-osmolality and hyponatraemia
0.838 0.162 0.000
M54.3 Sciatica
0.835 0.165 0.000
T42.4 Benzodiazepines
0.835 0.165 0.000
M45-M49 Spondylopathies
0.834 0.166 0.000
I73 Other peripheral vascular diseases
0.834 0.166 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.833 0.166 0.000
M34 Systemic sclerosis
0.831 0.169 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.830 0.170 0.000
M54.57 Low back pain (Lumbosacral region)
0.829 0.171 0.000
I05-I09 Chronic rheumatic heart diseases
0.828 0.172 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.824 0.176 0.000
X62 Intentional self-poisoning by and exposure to narcotics and psychodysleptics [hallucinogens], not elsewhere classified
0.822 0.178 0.000
M19 Other arthrosis
0.818 0.182 0.000
Y52.4 Angiotensin-converting-enzyme inhibitors
0.815 0.185 0.000
I67 Other cerebrovascular diseases
0.815 0.185 0.000
T43.0 Tricyclic and tetracyclic antidepressants
0.812 0.188 0.000
Chapter VIII Diseases of the ear and mastoid process
0.811 0.189 0.000
Y57.9 Drug or medicament, unspecified
0.811 0.189 0.000
G93.6 Cerebral oedema
0.810 0.190 0.000
T93 Sequelae of injuries of lower limb
0.810 0.190 0.000
G44 Other headache syndromes
0.805 0.195 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.804 0.196 0.000
M79.8 Other specified soft tissue disorders
0.804 0.196 0.000
S10-S19 Injuries to the neck
0.803 0.197 0.000
M25.8 Other specified joint disorders
0.799 0.201 0.000
Y45.0 Opioids and related analgesics
0.798 0.202 0.000
G40.2 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
0.798 0.202 0.000
I72 Other aneurysm
0.796 0.204 0.000
G93.8 Other specified disorders of brain
0.796 0.204 0.000
E87.6 Hypokalaemia
0.794 0.206 0.000
Y52.5 Other antihypertensive drugs, not elsewhere classified
0.794 0.206 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.794 0.206 0.000
T90.5 Sequelae of intracranial injury
0.791 0.209 0.000
M31 Other necrotising vasculopathies
0.789 0.211 0.000
T51 Toxic effect of alcohol
0.789 0.211 0.000
M54.4 Lumbago with sciatica
0.787 0.213 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.786 0.214 0.000
T91 Sequelae of injuries of neck and trunk
0.786 0.214 0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.781 0.219 0.000
Y85 Sequelae of transport accidents
0.779 0.221 0.000
T43.3 Phenothiazine antipsychotics and neuroleptics
0.778 0.222 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.777 0.223 0.000
S00.8 Superficial injury of other parts of head
0.775 0.225 0.000
M54.99 Dorsalgia, unspecified (Site unspecified)
0.774 0.226 0.000
M33 Dermatopolymyositis
0.774 0.226 0.000
M53 Other dorsopathies, not elsewhere classified
0.773 0.227 0.000
M75 Shoulder lesions
0.773 0.227 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.772 0.228 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.771 0.229 0.000
S22.0 Fracture of thoracic vertebra
0.771 0.229 0.000
M54.59 Low back pain (Site unspecified)
0.770 0.230 0.000
I27.2 Other secondary pulmonary hypertension
0.769 0.231 0.000
M24.2 Disorder of ligament
0.769 0.231 0.000
M79.2 Neuralgia and neuritis, unspecified
0.769 0.231 0.000
Y52.3 Coronary vasodilators, not elsewhere classified
0.769 0.231 0.000
Chapter V Mental and behavioural disorders
0.769 0.231 0.000
Y88 Sequelae of surgical and medical care as external cause
0.768 0.232 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.767 0.233 0.000
M25.46 Effusion of joint (Lower leg)
0.766 0.234 0.000
M21.3 Wrist or foot drop (acquired)
0.766 0.234 0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.766 0.234 0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.766 0.234 0.000
M79.0 Rheumatism, unspecified
0.765 0.234 0.000
S05 Injury of eye and orbit
0.765 0.235 0.000
H65-H75 Diseases of middle ear and mastoid
0.765 0.235 0.000
M67.1 Other contracture of tendon (sheath)
0.763 0.237 0.000
G25 Other extrapyramidal and movement disorders
0.763 0.237 0.000
S66 Injury of muscle and tendon at wrist and hand level
0.762 0.238 0.000
Chapter X Diseases of the respiratory system
0.762 0.238 0.000
V10-V19 Pedal cyclist injured in transport accident
0.761 0.238 0.000
G41 Status epilepticus
0.761 0.239 0.000
V40-V49 Car occupant injured in transport accident
0.759 0.241 0.000
I27.9 Pulmonary heart disease, unspecified
0.759 0.241 0.000
X62.9 Unspecified place
0.759 0.241 0.000
M66 Spontaneous rupture of synovium and tendon
0.759 0.241 0.000
E27 Other disorders of adrenal gland
0.759 0.241 0.000
Q60-Q64 Congenital malformations of the urinary system
0.757 0.243 0.000
G95 Other diseases of spinal cord
0.755 0.245 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.755 0.245 0.000
K70-K77 Diseases of liver
0.755 0.245 0.000
M79.69 Pain in limb (Site unspecified)
0.754 0.246 0.000
M25.78 Osteophyte (Other)
0.753 0.247 0.000
Y44.2 Anticoagulants
0.752 0.248 0.000
Chapter XXII Codes for special purposes
0.751 0.248 0.000
M25.5 Pain in joint
0.751 0.249 0.000
W20-W49 Exposure to inanimate mechanical forces
0.751 0.249 0.000
Y42.7 Androgens and anabolic congeners
0.751 0.249 0.000
Y43.3 Other antineoplastic drugs
0.751 0.249 0.000
G40.1 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
0.749 0.250 0.000
M19.9 Arthrosis, unspecified
0.749 0.251 0.000
J95-J99 Other diseases of the respiratory system
0.749 0.251 0.000
I77 Other disorders of arteries and arterioles
0.745 0.255 0.000
I67.8 Other specified cerebrovascular diseases
0.745 0.255 0.000
G93.1 Anoxic brain damage, not elsewhere classified
0.744 0.256 0.000
W50-W64 Exposure to animate mechanical forces
0.743 0.257 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.742 0.257 0.000
X20-X29 Contact with venomous animals and plants
0.742 0.258 0.000
Y40 Systemic antibiotics
0.742 0.258 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.741 0.259 0.000
M65.9 Synovitis and tenosynovitis, unspecified
0.741 0.259 0.000
M79.67 Pain in limb (Ankle and foot)
0.741 0.259 0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.741 0.259 0.000
G24 Dystonia
0.741 0.259 0.000
G99 Other disorders of nervous system in diseases classified elsewhere
0.739 0.261 0.000
T66-T78 Other and unspecified effects of external causes
0.739 0.261 0.000
S27 Injury of other and unspecified intrathoracic organs
0.739 0.261 0.000
H74 Other disorders of middle ear and mastoid
0.739 0.261 0.000
Y95 Nosocomial condition
0.738 0.261 0.000
K70 Alcoholic liver disease
0.738 0.262 0.000
K76 Other diseases of liver
0.738 0.262 0.000
M91-M94 Chondropathies
0.738 0.262 0.000
M65.8 Other synovitis and tenosynovitis
0.737 0.263 0.000
M25.31 Other instability of joint (Shoulder region)
0.734 0.265 0.000
E23 Hypofunction and other disorders of pituitary gland
0.734 0.266 0.000
V80-V89 Other land transport accidents
0.732 0.268 0.000
I73.9 Peripheral vascular disease, unspecified
0.731 0.269 0.000
T98 Sequelae of other and unspecified effects of external causes
0.731 0.269 0.000
M62 Other disorders of muscle
0.730 0.269 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.730 0.270 0.000
M48 Other spondylopathies
0.730 0.270 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.728 0.272 0.000
Y57.5 X-ray contrast media
0.727 0.273 0.000
M75.1 Rotator cuff syndrome
0.727 0.273 0.000
X63 Intentional self-poisoning by and exposure to other drugs acting on the autonomic nervous system
0.726 0.274 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.725 0.275 0.000
S61 Open wound of wrist and hand
0.725 0.275 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.724 0.275 0.000
G70-G73 Diseases of myoneural junction and muscle
0.722 0.278 0.000
M79.7 Fibromyalgia
0.722 0.278 0.000
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle
0.722 0.278 0.000
E87.7 Fluid overload
0.720 0.280 0.000
E40-E46 Malnutrition
0.717 0.282 0.000
T90.9 Sequelae of unspecified injury of head
0.717 0.283 0.000
M00-M03 Infectious arthropathies
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
Y35-Y36 Legal intervention and operations of war
0.717 0.283 0.000
Y10-Y34 Event of undetermined intent
0.717 0.283 0.000
Y00-Y09 Assault
0.717 0.283 0.000
X85-X99 Assault
0.717 0.283 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.717 0.283 0.000
X50-X57 Overexertion, travel and privation
0.717 0.283 0.000
X30-X39 Exposure to forces of nature
0.717 0.283 0.000
X10-X19 Contact with heat and hot substances
0.717 0.283 0.000
X00-X09 Exposure to smoke, fire and flames
0.717 0.283 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.717 0.283 0.000
W75-W84 Other accidental threats to breathing
0.717 0.283 0.000
W65-W74 Accidental drowning and submersion
0.717 0.283 0.000
V98-V99 Other and unspecified transport accidents
0.717 0.283 0.000
V95-V97 Air and space transport accidents
0.717 0.283 0.000
V90-V94 Water transport accidents
0.717 0.283 0.000
V70-V79 Bus occupant injured in transport accident
0.717 0.283 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.717 0.283 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.717 0.283 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.717 0.283 0.000
V01-V09 Pedestrian injured in transport accident
0.717 0.283 0.000
Chapter XI Diseases of the digestive system
0.716 0.284 0.000
G83 Other paralytic syndromes
0.716 0.284 0.000
G46 Vascular syndromes of brain in cerebrovascular diseases
0.716 0.284 0.000
S22.00 Fracture of thoracic vertebra (closed)
0.716 0.284 0.000
Y59 Other and unspecified vaccines and biological substances
0.715 0.284 0.000
Y58 Bacterial vaccines
0.715 0.284 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.715 0.284 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.715 0.284 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.715 0.284 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.715 0.284 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.715 0.284 0.000
Y48 Anaesthetics and therapeutic gases
0.715 0.284 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.715 0.284 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.715 0.284 0.000
G40.8 Other epilepsy
0.715 0.285 0.000
G40.7 Petit mal, unspecified, without grand mal seizures
0.715 0.285 0.000
G40.4 Other generalised epilepsy and epileptic syndromes
0.715 0.285 0.000
G40.0 Localisation-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localised onset
0.715 0.285 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.715 0.285 0.000
M40-M43 Deforming dorsopathies
0.715 0.285 0.000
Q21 Congenital malformations of cardiac septa
0.714 0.286 0.000
M34.9 Systemic sclerosis, unspecified
0.714 0.286 0.000
M25.57 Pain in joint (Ankle and foot)
0.714 0.286 0.000
M24.0 Loose body in joint
0.714 0.286 0.000
S70-S79 Injuries to the hip and thigh
0.713 0.286 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.713 0.287 0.000
M32 Systemic lupus erythematosus
0.713 0.287 0.000
M30 Polyarteritis nodosa and related conditions
0.713 0.287 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.713 0.287 0.000
S02.4 Fracture of malar and maxillary bones
0.712 0.288 0.000
M25.9 Joint disorder, unspecified
0.711 0.288 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.711 0.289 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.711 0.289 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.711 0.289 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.711 0.289 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.711 0.289 0.000
T36 Poisoning by systemic antibiotics
0.711 0.289 0.000
E50-E64 Other nutritional deficiencies
0.711 0.289 0.000
M54.1 Radiculopathy
0.710 0.290 0.000
I27.8 Other specified pulmonary heart diseases
0.710 0.290 0.000
J95 Postprocedural respiratory disorders, not elsewhere classified
0.709 0.291 0.000
M19.94 Arthrosis, unspecified (Hand)
0.709 0.291 0.000
I00-I02 Acute rheumatic fever
0.709 0.291 0.000
I69.8 Sequelae of other and unspecified cerebrovascular diseases
0.708 0.292 0.000
M76 Enthesopathies of lower limb, excluding foot
0.708 0.292 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.708 0.292 0.000
S64 Injury of nerves at wrist and hand level
0.707 0.293 0.000
S90 Superficial injury of ankle and foot
0.707 0.293 0.000
J98 Other respiratory disorders
0.707 0.293 0.000
G94 Other disorders of brain in diseases classified elsewhere
0.706 0.293 0.000
G90 Disorders of autonomic nervous system
0.706 0.293 0.000
G98 Other disorders of nervous system, not elsewhere classified
0.706 0.293 0.000
G92 Toxic encephalopathy
0.706 0.293 0.000
I69.0 Sequelae of subarachnoid haemorrhage
0.706 0.293 0.000
M25.0 Haemarthrosis
0.706 0.294 0.000
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction
0.706 0.294 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.706 0.294 0.000
M54.36 Sciatica (Lumbar region)
0.706 0.294 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.706 0.294 0.000
G45 Transient cerebral ischaemic attacks and related syndromes
0.706 0.294 0.000
I69.1 Sequelae of intracerebral haemorrhage
0.706 0.294 0.000
E87.5 Hyperkalaemia
0.706 0.294 0.000
M80-M85 Disorders of bone density and structure
0.706 0.294 0.000
G91.1 Obstructive hydrocephalus
0.706 0.294 0.000
M77.5 Other enthesopathy of foot
0.705 0.295 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.705 0.295 0.000
M18 Arthrosis of first carpometacarpal joint
0.705 0.295 0.000
E74 Other disorders of carbohydrate metabolism
0.705 0.295 0.000
H74.4 Polyp of middle ear
0.704 0.296 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.703 0.297 0.000
M25.2 Flail joint
0.703 0.297 0.000
M25.1 Fistula of joint
0.703 0.297 0.000
M54.8 Other dorsalgia
0.703 0.297 0.000
M54.0 Panniculitis affecting regions of neck and back
0.703 0.297 0.000
V20-V29 Motorcycle rider injured in transport accident
0.701 0.298 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.701 0.299 0.000
I71.3 Abdominal aortic aneurysm, ruptured
0.701 0.299 0.000
M79.65 Pain in limb (Pelvic region and thigh)
0.701 0.299 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.700 0.299 0.000
T95 Sequelae of burns, corrosions and frostbite
0.700 0.299 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.700 0.299 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.700 0.299 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.700 0.299 0.000
E87.0 Hyperosmolality and hypernatraemia
0.699 0.301 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.698 0.301 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.697 0.302 0.000
M35 Other systemic involvement of connective tissue
0.697 0.302 0.000
S46 Injury of muscle and tendon at shoulder and upper arm level
0.697 0.303 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.697 0.303 0.000
S02.1 Fracture of base of skull
0.696 0.303 0.000
S62 Fracture at wrist and hand level
0.695 0.305 0.000
M79.5 Residual foreign body in soft tissue
0.695 0.305 0.000
M86-M90 Other osteopathies
0.695 0.305 0.000
E24 Cushing's syndrome
0.694 0.306 0.000
Q50-Q56 Congenital malformations of genital organs
0.692 0.307 0.000
M65.4 Radial styloid tenosynovitis [de Quervain]
0.692 0.307 0.000
M72 Fibroblastic disorders
0.692 0.308 0.000
M79.1 Myalgia
0.692 0.308 0.000
M54.55 Low back pain (Thoracolumbar region)
0.692 0.308 0.000
M54.54 Low back pain-Thoracic
0.692 0.308 0.000
M54.53 Low back pain-Cervicothoracic
0.692 0.308 0.000
M54.52 Low back pain-Cervical
0.692 0.308 0.000
M54.51 Low back pain-Occipit-atl-axl
0.692 0.308 0.000
M25.75 Osteophyte (Pelvic region and thigh)
0.691 0.308 0.000
T40.2 Other opioids
0.691 0.309 0.000
S02.3 Fracture of orbital floor
0.691 0.309 0.000
X41 Accidental poisoning by and exposure to antiepileptic, sedative-hypnotic, anti-Parkinsonism and psychotropic drugs, not elsewhere classified
0.690 0.310 0.000
M19.91 Arthrosis, unspecified (Shoulder region)
0.689 0.311 0.000
T92 Sequelae of injuries of upper limb
0.689 0.311 0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.689 0.311 0.000
S00.2 Other superficial injuries of eyelid and periocular area
0.689 0.311 0.000
M71 Other bursopathies
0.688 0.312 0.000
Y43.1 Antineoplastic antimetabolites
0.688 0.312 0.000
T79-T79 Certain early complications of trauma
0.688 0.312 0.000
I05 Rheumatic mitral valve diseases
0.687 0.313 0.000
M21.37 Wrist or foot drop (acquired) (Ankle and foot)
0.686 0.314 0.000
Y52.2 Other antidysrhythmic drugs, not elsewhere classified
0.686 0.314 0.000
M21.1 Varus deformity, not elsewhere classified
0.686 0.314 0.000
M79.9 Soft tissue disorder, unspecified
0.684 0.316 0.000
M79.4 Hypertrophy of (infrapatellar) fat pad
0.684 0.316 0.000
M79.3 Panniculitis, unspecified
0.684 0.316 0.000
T43.9 Psychotropic drug, unspecified
0.681 0.319 0.000
T43.8 Other psychotropic drugs, not elsewhere classified
0.681 0.319 0.000
T43.6 Psychostimulants with abuse potential
0.681 0.319 0.000
T43.4 Butyrophenone and thioxanthene neuroleptics
0.681 0.319 0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.681 0.319 0.000
M65.96 Synovitis and tenosynovitis, unspecified (Lower leg)
0.681 0.319 0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.680 0.320 0.000
M17 Gonarthrosis [arthrosis of knee]
0.679 0.321 0.000
S00.3 Superficial injury of nose
0.679 0.321 0.000
Q00-Q07 Congenital malformations of the nervous system
0.679 0.321 0.000
J98.1 Pulmonary collapse
0.678 0.322 0.000
T51.0 Ethanol
0.677 0.323 0.000
X49 Accidental poisoning by and exposure to other and unspecified chemicals and noxious substances
0.677 0.323 0.000
S49 Other and unspecified injuries of shoulder and upper arm
0.677 0.323 0.000
K75 Other inflammatory liver diseases
0.677 0.323 0.000
Y89 Sequelae of other external causes
0.676 0.323 0.000
Y87 Sequelae of intentional self-harm, assault and events of undetermined intent
0.676 0.323 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.676 0.324 0.000
Q35-Q37 Cleft lip and cleft palate
0.676 0.324 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.676 0.324 0.000
H71 Cholesteatoma of middle ear
0.676 0.324 0.000
M77.9 Enthesopathy, unspecified
0.675 0.324 0.000
I67.9 Cerebrovascular disease, unspecified
0.675 0.325 0.000
K76.9 Liver disease, unspecified
0.675 0.325 0.000
Q80-Q89 Other congenital malformations
0.675 0.325 0.000
M25.76 Osteophyte (Lower leg)
0.674 0.326 0.000
S08 Traumatic amputation of part of head
0.674 0.326 0.000
S07 Crushing injury of head
0.674 0.326 0.000
S04 Injury of cranial nerves
0.674 0.326 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.674 0.326 0.000
Q18 Other congenital malformations of face and neck
0.674 0.326 0.000
Y52.9 Other and unspecified agents primarily affecting the cardiovascular system
0.673 0.326 0.000
Y52.8 Antivaricose drugs, including sclerosing agents
0.673 0.326 0.000
Y52.7 Peripheral vasodilators
0.673 0.326 0.000
Y52.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.673 0.326 0.000
Y52.1 Calcium-channel blockers
0.673 0.326 0.000
Y52.0 Cardiac-stimulant glycosides and drugs of similar action
0.673 0.326 0.000
M77.0 Medial epicondylitis
0.673 0.327 0.000
E87.3 Alkalosis
0.673 0.327 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.673 0.327 0.000
I70 Atherosclerosis
0.672 0.327 0.000
I74.5 Embolism and thrombosis of iliac artery
0.672 0.328 0.000
S66.7 Injury of multiple extensor muscles and tendons at wrist and hand level
0.672 0.328 0.000
I28 Other diseases of pulmonary vessels
0.672 0.328 0.000
S40 Superficial injury of shoulder and upper arm
0.672 0.328 0.000
G93.7 Reye's syndrome
0.671 0.329 0.000
G93.5 Compression of brain
0.671 0.329 0.000
G93.2 Benign intracranial hypertension
0.671 0.329 0.000
T90.8 Sequelae of other specified injuries of head
0.670 0.330 0.000
T90.3 Sequelae of injury of cranial nerves
0.670 0.330 0.000
T90.1 Sequelae of open wound of head
0.670 0.330 0.000
T90.0 Sequelae of superficial injury of head
0.670 0.330 0.000
K70.3 Alcoholic cirrhosis of liver
0.670 0.330 0.000
I60 Subarachnoid haemorrhage
0.670 0.330 0.000
M25.77 Osteophyte (Ankle and foot)
0.669 0.331 0.000
F10 Mental and behavioural disorders due to use of alcohol
0.668 0.332 0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.665 0.334 0.000
M25.47 Effusion of joint (Ankle and foot)
0.665 0.335 0.000
S29 Other and unspecified injuries of thorax
0.665 0.335 0.000
M24.5 Contracture of joint
0.665 0.335 0.000
S41 Open wound of shoulder and upper arm
0.664 0.336 0.000
M54.50 Low back pain (Multiple sites in spine)
0.664 0.336 0.000
K76.6 Portal hypertension
0.664 0.336 0.000
M54.6 Pain in thoracic spine
0.663 0.337 0.000
T51.9 Alcohol, unspecified
0.662 0.338 0.000
I77.9 Disorder of arteries and arterioles, unspecified
0.662 0.338 0.000
G82 Paraplegia and tetraplegia
0.662 0.338 0.000
M54.49 Lumbago with sciatica (Site unspecified)
0.662 0.338 0.000
M77.1 Lateral epicondylitis
0.661 0.339 0.000
E27.1 Primary adrenocortical insufficiency
0.661 0.339 0.000
S06 Intracranial injury
0.660 0.339 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.659 0.341 0.000
E85 Amyloidosis
0.658 0.341 0.000
E84 Cystic fibrosis
0.658 0.341 0.000
E79 Disorders of purine and pyrimidine metabolism
0.658 0.341 0.000
E77 Disorders of glycoprotein metabolism
0.658 0.341 0.000
E76 Disorders of glycosaminoglycan metabolism
0.658 0.341 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.658 0.341 0.000
E73 Lactose intolerance
0.658 0.341 0.000
E72 Other disorders of amino-acid metabolism
0.658 0.341 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.658 0.341 0.000
E70 Disorders of aromatic amino-acid metabolism
0.658 0.341 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.658 0.341 0.000
E83 Disorders of mineral metabolism
0.658 0.342 0.000
T93.3 Sequelae of dislocation, sprain and strain of lower limb
0.658 0.342 0.000
G91.8 Other hydrocephalus
0.658 0.342 0.000
G91.3 Posttraumatic hydrocephalus, unspecified
0.658 0.342 0.000
G91.2 Normal-pressure hydrocephalus
0.658 0.342 0.000
G91.0 Communicating hydrocephalus
0.658 0.342 0.000
I62 Other nontraumatic intracranial haemorrhage
0.658 0.342 0.000
I08 Multiple valve diseases
0.658 0.342 0.000
M79.80 Other specified soft tissue disorders (Multiple sites)
0.658 0.342 0.000
G44.8 Other specified headache syndromes
0.657 0.343 0.000
E22 Hyperfunction of pituitary gland
0.656 0.344 0.000
S28 Crushing injury of thorax and traumatic amputation of part of thorax
0.656 0.344 0.000
S26 Injury of heart
0.656 0.344 0.000
S25 Injury of blood vessels of thorax
0.656 0.344 0.000
S24 Injury of nerves and spinal cord at thorax level
0.656 0.344 0.000
S23 Dislocation, sprain and strain of joints and ligaments of thorax
0.656 0.344 0.000
S21 Open wound of thorax
0.656 0.344 0.000
I74.9 Embolism and thrombosis of unspecified artery
0.656 0.344 0.000
I27.1 Kyphoscoliotic heart disease
0.656 0.344 0.000
G43 Migraine
0.655 0.345 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.655 0.345 0.000
G31.8 Other specified degenerative diseases of nervous system
0.653 0.346 0.000
K70.4 Alcoholic hepatic failure
0.653 0.347 0.000
X84 Intentional self-harm by unspecified means
0.653 0.347 0.000
X83 Intentional self-harm by other specified means
0.653 0.347 0.000
X82 Intentional self-harm by crashing of motor vehicle
0.653 0.347 0.000
X81 Intentional self-harm by jumping or lying before moving object
0.653 0.347 0.000
X80 Intentional self-harm by jumping from a high place
0.653 0.347 0.000
X79 Intentional self-harm by blunt object
0.653 0.347 0.000
X78 Intentional self-harm by sharp object
0.653 0.347 0.000
X77 Intentional self-harm by steam, hot vapours and hot objects
0.653 0.347 0.000
X76 Intentional self-harm by smoke, fire and flames
0.653 0.347 0.000
X75 Intentional self-harm by explosive material
0.653 0.347 0.000
X74 Intentional self-harm by other and unspecified firearm discharge
0.653 0.347 0.000
X73 Intentional self-harm by rifle, shotgun and larger firearm discharge
0.653 0.347 0.000
X72 Intentional self-harm by handgun discharge
0.653 0.347 0.000
X71 Intentional self-harm by drowning and submersion
0.653 0.347 0.000
X70 Intentional self-harm by hanging, strangulation and suffocation
0.653 0.347 0.000
X69 Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
0.653 0.347 0.000
X68 Intentional self-poisoning by and exposure to pesticides
0.653 0.347 0.000
X67 Intentional self-poisoning by and exposure to other gases and vapours
0.653 0.347 0.000
X66 Intentional self-poisoning by and exposure to organic solvents and halogenated hydrocarbons and their vapours
0.653 0.347 0.000
X65 Intentional self-poisoning by and exposure to alcohol
0.653 0.347 0.000
X64 Intentional self-poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
0.653 0.347 0.000
X61 Intentional self-poisoning by and exposure to antiepileptic, sedative-hypnotic, anti-Parkinsonism and psychotropic drugs, not elsewhere classified
0.653 0.347 0.000
X60 Intentional self-poisoning by and exposure to nonopioid analgesics, antipyretics and antirheumatics
0.653 0.347 0.000
M48.0 Spinal stenosis
0.653 0.347 0.000
I71.8 Aortic aneurysm of unspecified site, ruptured
0.653 0.347 0.000
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.653 0.347 0.000
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.653 0.347 0.000
I71.1 Thoracic aortic aneurysm, ruptured
0.653 0.347 0.000
M25.71 Osteophyte (Shoulder region)
0.651 0.349 0.000
I72.0 Aneurysm of carotid artery
0.651 0.349 0.000
I98 Other disorders of circulatory system in diseases classified elsewhere
0.651 0.349 0.000
S22.4 Multiple fractures of ribs
0.651 0.349 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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