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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2089222
log Bayes Factor = 1.58966
Chromosome 12   position 117,002,658  (GRCh37) Explore rs2089222 on Ensembl!
Variant rs2089222 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
0.973 0.027 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.972 0.028 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.969 0.031 0.000
Chapter VI Diseases of the nervous system
0.962 0.038 0.000
M20-M25 Other joint disorders
0.961 0.039 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.943 0.057 0.000
S70-S79 Injuries to the hip and thigh
0.939 0.061 0.000
S80-S89 Injuries to the knee and lower leg
0.915 0.085 0.000
M23 Internal derangement of knee
0.913 0.087 0.000
M21 Other acquired deformities of limbs
0.910 0.090 0.000
G20-G26 Extrapyramidal and movement disorders
0.903 0.097 0.000
Chapter I Certain infectious and parasitic diseases
0.900 0.100 0.000
Chapter V Mental and behavioural disorders
0.887 0.113 0.000
S72 Fracture of femur
0.878 0.122 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.874 0.126 0.000
M65-M68 Disorders of synovium and tendon
0.873 0.127 0.000
Chapter VII Diseases of the eye and adnexa
0.868 0.132 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.865 0.135 0.000
Chapter XX External causes of morbidity and mortality
0.865 0.135 0.000
S81 Open wound of lower leg
0.864 0.136 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.860 0.140 0.000
M25 Other joint disorders, not elsewhere classified
0.859 0.141 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.858 0.142 0.000
G90-G99 Other disorders of the nervous system
0.858 0.142 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.854 0.146 0.000
M80-M85 Disorders of bone density and structure
0.854 0.146 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.850 0.150 0.000
M91-M94 Chondropathies
0.844 0.156 0.000
M24 Other specific joint derangements
0.842 0.158 0.000
G20 Parkinson's disease
0.834 0.166 0.000
G56 Mononeuropathies of upper limb
0.829 0.171 0.000
M86-M90 Other osteopathies
0.828 0.172 0.000
A30-A49 Other bacterial diseases
0.826 0.174 0.000
S79 Other and unspecified injuries of hip and thigh
0.826 0.174 0.000
M70-M79 Other soft tissue disorders
0.825 0.175 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.823 0.177 0.000
S82 Fracture of lower leg, including ankle
0.822 0.178 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.821 0.179 0.000
M23.4 Loose body in knee
0.820 0.180 0.000
E70-E90 Metabolic disorders
0.813 0.187 0.000
G56.0 Carpal tunnel syndrome
0.813 0.187 0.000
S72.0 Fracture of neck of femur
0.808 0.192 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.798 0.202 0.000
M65 Synovitis and tenosynovitis
0.795 0.205 0.000
E20-E35 Disorders of other endocrine glands
0.794 0.206 0.000
F43 Reaction to severe stress, and adjustment disorders
0.793 0.207 0.000
M21.0 Valgus deformity, not elsewhere classified
0.792 0.208 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.788 0.212 0.000
Q21 Congenital malformations of cardiac septa
0.788 0.212 0.000
A49 Bacterial infection of unspecified site
0.785 0.215 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.783 0.217 0.000
M84 Disorders of continuity of bone
0.781 0.219 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.780 0.220 0.000
M23.2 Derangement of meniscus due to old tear or injury
0.780 0.220 0.000
S40-S49 Injuries to the shoulder and upper arm
0.780 0.220 0.000
E83 Disorders of mineral metabolism
0.779 0.221 0.000
S90-S99 Injuries to the ankle and foot
0.776 0.224 0.000
G70-G73 Diseases of myoneural junction and muscle
0.775 0.225 0.000
S60-S69 Injuries to the wrist and hand
0.769 0.231 0.000
R41 Other symptoms and signs involving cognitive functions and awareness
0.769 0.231 0.000
S81.9 Open wound of lower leg, part unspecified
0.768 0.232 0.000
Q50-Q56 Congenital malformations of genital organs
0.767 0.233 0.000
M21.7 Unequal limb length (acquired)
0.765 0.235 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.761 0.239 0.000
F41 Other anxiety disorders
0.759 0.241 0.000
S20-S29 Injuries to the thorax
0.758 0.242 0.000
S72.00 Fracture of neck of femur (closed)
0.758 0.242 0.000
M93 Other osteochondropathies
0.757 0.243 0.000
G57 Mononeuropathies of lower limb
0.756 0.244 0.000
S81.0 Open wound of knee
0.756 0.244 0.000
S30 Superficial injury of abdomen, lower back and pelvis
0.755 0.245 0.000
M23.8 Other internal derangements of knee
0.755 0.245 0.000
M23.49 Loose body in knee-Unspec lig/men
0.753 0.247 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.751 0.249 0.000
M23.22 Derangement of meniscus due to old tear or injury (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.749 0.251 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.747 0.253 0.000
Q60-Q64 Congenital malformations of the urinary system
0.747 0.253 0.000
T18 Foreign body in alimentary tract
0.746 0.254 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.745 0.255 0.000
S79.9 Unspecified injury of hip and thigh
0.745 0.255 0.000
E83.5 Disorders of calcium metabolism
0.744 0.256 0.000
Q00-Q07 Congenital malformations of the nervous system
0.743 0.257 0.000
G25 Other extrapyramidal and movement disorders
0.742 0.258 0.000
B07 Viral warts
0.741 0.259 0.000
R41.0 Disorientation, unspecified
0.740 0.260 0.000
G95 Other diseases of spinal cord
0.740 0.260 0.000
S82.8 Fractures of other parts of lower leg
0.738 0.262 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.737 0.262 0.000
Q21.1 Atrial septal defect
0.736 0.264 0.000
G30-G32 Other degenerative diseases of the nervous system
0.734 0.266 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.733 0.267 0.000
S72.1 Pertrochanteric fracture
0.732 0.268 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.731 0.269 0.000
S10-S19 Injuries to the neck
0.731 0.269 0.000
M77 Other enthesopathies
0.730 0.270 0.000
M21.2 Flexion deformity
0.728 0.272 0.000
H04 Disorders of lachrymal system
0.725 0.275 0.000
W20-W49 Exposure to inanimate mechanical forces
0.724 0.276 0.000
V40-V49 Car occupant injured in transport accident
0.722 0.278 0.000
M21.6 Other acquired deformities of ankle and foot
0.721 0.279 0.000
Q80-Q89 Other congenital malformations
0.720 0.280 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.720 0.280 0.000
M24.2 Disorder of ligament
0.717 0.283 0.000
F43.2 Adjustment disorders
0.716 0.284 0.000
M25.3 Other instability of joint
0.715 0.285 0.000
E83.4 Disorders of magnesium metabolism
0.713 0.287 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.712 0.288 0.000
M25.8 Other specified joint disorders
0.712 0.288 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.711 0.289 0.000
R41.8 Other and unspecified symptoms and signs involving cognitive functions and awareness
0.709 0.291 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.705 0.295 0.000
G91 Hydrocephalus
0.704 0.296 0.000
Q27 Other congenital malformations of peripheral vascular system
0.702 0.298 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.701 0.299 0.000
T79-T79 Certain early complications of trauma
0.701 0.299 0.000
A49.8 Other bacterial infections of unspecified site
0.700 0.300 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.699 0.300 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.698 0.302 0.000
M00-M03 Infectious arthropathies
0.697 0.303 0.000
T33-T35 Frostbite
0.697 0.303 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.697 0.303 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.697 0.303 0.000
T00-T07 Injuries involving multiple body regions
0.697 0.303 0.000
G56.8 Other mononeuropathies of upper limb
0.695 0.305 0.000
M60-M63 Disorders of muscles
0.695 0.305 0.000
S70 Superficial injury of hip and thigh
0.695 0.305 0.000
M93.9 Osteochondropathy, unspecified
0.694 0.306 0.000
A15-A19 Tuberculosis
0.694 0.306 0.000
S82.6 Fracture of lateral malleolus
0.694 0.306 0.000
T66-T78 Other and unspecified effects of external causes
0.691 0.309 0.000
H00 Hordeolum and chalazion
0.690 0.310 0.000
F30-F39 Mood [affective] disorders
0.690 0.310 0.000
B50-B64 Protozoal diseases
0.689 0.311 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.689 0.311 0.000
M33 Dermatopolymyositis
0.689 0.311 0.000
M32 Systemic lupus erythematosus
0.689 0.311 0.000
M30 Polyarteritis nodosa and related conditions
0.689 0.311 0.000
M89 Other disorders of bone
0.688 0.312 0.000
Chapter XXII Codes for special purposes
0.688 0.312 0.000
A80-A89 Viral infections of the central nervous system
0.684 0.315 0.000
T17 Foreign body in respiratory tract
0.682 0.318 0.000
G57.6 Lesion of plantar nerve
0.681 0.319 0.000
M24.5 Contracture of joint
0.680 0.319 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.679 0.321 0.000
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot
0.679 0.321 0.000
F41.0 Panic disorder [episodic paroxysmal anxiety]
0.678 0.322 0.000
G94 Other disorders of brain in diseases classified elsewhere
0.678 0.322 0.000
S72.3 Fracture of shaft of femur
0.677 0.323 0.000
S82.80 Fractures of other parts of lower leg (closed)
0.677 0.323 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.676 0.324 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.676 0.324 0.000
Q35-Q37 Cleft lip and cleft palate
0.676 0.324 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.676 0.324 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.676 0.324 0.000
M84.0 Malunion of fracture
0.676 0.324 0.000
F43.1 Posttraumatic stress disorder
0.675 0.324 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.675 0.325 0.000
M21.06 Valgus deformity, not elsewhere classified (Lower leg)
0.675 0.325 0.000
E40-E46 Malnutrition
0.674 0.326 0.000
M65.9 Synovitis and tenosynovitis, unspecified
0.674 0.326 0.000
A49.0 Staphylococcal infection, unspecified
0.673 0.327 0.000
S78 Traumatic amputation of hip and thigh
0.673 0.327 0.000
S77 Crushing injury of hip and thigh
0.673 0.327 0.000
S76 Injury of muscle and tendon at hip and thigh level
0.673 0.327 0.000
S75 Injury of blood vessels at hip and thigh level
0.673 0.327 0.000
S74 Injury of nerves at hip and thigh level
0.673 0.327 0.000
S73 Dislocation, sprain and strain of joint and ligaments of hip
0.673 0.327 0.000
S71 Open wound of hip and thigh
0.673 0.327 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.673 0.327 0.000
Chapter II Neoplasms
0.672 0.328 0.000
S64 Injury of nerves at wrist and hand level
0.671 0.329 0.000
E28 Ovarian dysfunction
0.671 0.329 0.000
M23.25 Derangement of meniscus due to old tear or injury (Posterior horn of lateral meniscus)
0.670 0.330 0.000
M34 Systemic sclerosis
0.670 0.330 0.000
H04.2 Epiphora
0.669 0.331 0.000
M23.29 Derangement of meniscus due to old tear or injury (Unspecified ligament or Unspecified meniscus)
0.668 0.331 0.000
F03 Unspecified dementia
0.668 0.332 0.000
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)
0.668 0.332 0.000
G83 Other paralytic syndromes
0.667 0.333 0.000
T18.1 Foreign body in oesophagus
0.666 0.334 0.000
M21.3 Wrist or foot drop (acquired)
0.665 0.335 0.000
H43-H45 Disorders of vitreous body and globe
0.664 0.336 0.000
M65.8 Other synovitis and tenosynovitis
0.664 0.336 0.000
M05-M14 Inflammatory polyarthropathies
0.663 0.337 0.000
S32 Fracture of lumbar spine and pelvis
0.663 0.337 0.000
G25.0 Essential tremor
0.662 0.338 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.662 0.338 0.000
M21.75 Unequal limb length (acquired) (Pelvic region and thigh)
0.660 0.340 0.000
S86 Injury of muscle and tendon at lower leg level
0.660 0.340 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.659 0.341 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.658 0.342 0.000
E86 Volume depletion
0.657 0.343 0.000
G24 Dystonia
0.656 0.344 0.000
S88 Traumatic amputation of lower leg
0.656 0.344 0.000
S87 Crushing injury of lower leg
0.656 0.344 0.000
S85 Injury of blood vessels at lower leg level
0.656 0.344 0.000
S84 Injury of nerves at lower leg level
0.656 0.344 0.000
S82.1 Fracture of upper end of tibia
0.656 0.344 0.000
S81.8 Open wound of other parts of lower leg
0.655 0.345 0.000
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)
0.655 0.345 0.000
M23.9 Internal derangement of knee, unspecified
0.655 0.345 0.000
M23.6 Other spontaneous disruption of ligament(s) of knee
0.655 0.345 0.000
M23.1 Discoid meniscus (congenital)
0.655 0.345 0.000
M23.0 Cystic meniscus
0.655 0.345 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.653 0.346 0.000
M21.9 Acquired deformity of limb, unspecified
0.652 0.347 0.000
M21.8 Other specified acquired deformities of limbs
0.652 0.347 0.000
M21.4 Flat foot [pes planus] (acquired)
0.652 0.347 0.000
G54 Nerve root and plexus disorders
0.652 0.348 0.000
T92 Sequelae of injuries of upper limb
0.651 0.349 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.651 0.349 0.000
B00 Herpesviral [herpes simplex] infections
0.651 0.349 0.000
R45 Symptoms and signs involving emotional state
0.649 0.351 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.649 0.351 0.000
G50 Disorders of trigeminal nerve
0.648 0.352 0.000
G23 Other degenerative diseases of basal ganglia
0.648 0.352 0.000
G21 Secondary Parkinsonism
0.648 0.352 0.000
G26 Extrapyramidal and movement disorders in diseases classified elsewhere
0.648 0.352 0.000
G22 Parkinsonism in diseases classified elsewhere
0.648 0.352 0.000
S82.5 Fracture of medial malleolus
0.647 0.353 0.000
M82 Osteoporosis in diseases classified elsewhere
0.647 0.353 0.000
M84.1 Nonunion of fracture [pseudarthrosis]
0.647 0.353 0.000
F45 Somatoform disorders
0.647 0.353 0.000
B99-B99 Other infectious diseases
0.645 0.354 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.645 0.354 0.000
B65-B83 Helminthiases
0.645 0.354 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.645 0.354 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.645 0.354 0.000
A75-A79 Rickettsioses
0.645 0.354 0.000
A70-A74 Other diseases caused by chlamydiae
0.645 0.354 0.000
A65-A69 Other spirochaetal diseases
0.645 0.354 0.000
A20-A28 Certain zoonotic bacterial diseases
0.645 0.354 0.000
B25-B34 Other viral diseases
0.645 0.355 0.000
M67 Other disorders of synovium and tendon
0.645 0.355 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.645 0.355 0.000
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle
0.644 0.356 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.643 0.357 0.000
X60-X84 Intentional self-harm
0.642 0.358 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.642 0.358 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.642 0.358 0.000
M80 Osteoporosis with pathological fracture
0.640 0.360 0.000
E16 Other disorders of pancreatic internal secretion
0.640 0.360 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.639 0.361 0.000
M72 Fibroblastic disorders
0.638 0.362 0.000
S80 Superficial injury of lower leg
0.637 0.362 0.000
M90 Osteopathies in diseases classified elsewhere
0.637 0.363 0.000
M66 Spontaneous rupture of synovium and tendon
0.637 0.363 0.000
M23.3 Other meniscus derangements
0.637 0.363 0.000
M31 Other necrotising vasculopathies
0.637 0.363 0.000
M25.61 Stiffness of joint, not elsewhere classified (Shoulder region)
0.636 0.364 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.636 0.364 0.000
F70-F79 Mental retardation
0.636 0.364 0.000
A46 Erysipelas
0.636 0.364 0.000
M25.7 Osteophyte
0.635 0.364 0.000
H00.0 Hordeolum and other deep inflammation of eyelid
0.635 0.365 0.000
M24.1 Other articular cartilage disorders
0.635 0.365 0.000
W50-W64 Exposure to animate mechanical forces
0.634 0.366 0.000
S89 Other and unspecified injuries of lower leg
0.633 0.366 0.000
H53-H54 Visual disturbances and blindness
0.633 0.367 0.000
E50-E64 Other nutritional deficiencies
0.633 0.367 0.000
S30.1 Contusion of abdominal wall
0.632 0.368 0.000
M23.5 Chronic instability of knee
0.632 0.368 0.000
M21.07 Valgus deformity, not elsewhere classified (Ankle and foot)
0.631 0.369 0.000
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level
0.631 0.369 0.000
F41.1 Generalised anxiety disorder
0.631 0.369 0.000
E88 Other metabolic disorders
0.631 0.369 0.000
A00-A09 Intestinal infectious diseases
0.630 0.370 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.630 0.370 0.000
S72.9 Fracture of femur, part unspecified
0.629 0.370 0.000
S72.8 Fractures of other parts of femur
0.629 0.370 0.000
S72.7 Multiple fractures of femur
0.629 0.370 0.000
G99 Other disorders of nervous system in diseases classified elsewhere
0.629 0.371 0.000
M25.0 Haemarthrosis
0.628 0.372 0.000
M23.81 Other internal derangements of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.628 0.372 0.000
S72.10 Pertrochanteric fracture (closed)
0.628 0.372 0.000
M24.23 Disorder of ligament (Forearm)
0.628 0.372 0.000
H21 Other disorders of iris and ciliary body
0.627 0.373 0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.626 0.374 0.000
G90 Disorders of autonomic nervous system
0.626 0.374 0.000
S72.2 Subtrochanteric fracture
0.626 0.374 0.000
T98 Sequelae of other and unspecified effects of external causes
0.625 0.375 0.000
R80 Isolated proteinuria
0.625 0.375 0.000
M40-M43 Deforming dorsopathies
0.623 0.377 0.000
T90 Sequelae of injuries of head
0.622 0.378 0.000
B15-B19 Viral hepatitis
0.621 0.379 0.000
H10-H13 Disorders of conjunctiva
0.621 0.379 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.620 0.379 0.000
G53 Cranial nerve disorders in diseases classified elsewhere
0.620 0.380 0.000
G52 Disorders of other cranial nerves
0.620 0.380 0.000
R40 Somnolence, stupor and coma
0.620 0.380 0.000
Y35-Y36 Legal intervention and operations of war
0.620 0.380 0.000
Y10-Y34 Event of undetermined intent
0.620 0.380 0.000
Y00-Y09 Assault
0.620 0.380 0.000
X85-X99 Assault
0.620 0.380 0.000
X50-X57 Overexertion, travel and privation
0.620 0.380 0.000
X30-X39 Exposure to forces of nature
0.620 0.380 0.000
X10-X19 Contact with heat and hot substances
0.620 0.380 0.000
X00-X09 Exposure to smoke, fire and flames
0.620 0.380 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.620 0.380 0.000
W75-W84 Other accidental threats to breathing
0.620 0.380 0.000
W65-W74 Accidental drowning and submersion
0.620 0.380 0.000
V98-V99 Other and unspecified transport accidents
0.620 0.380 0.000
V95-V97 Air and space transport accidents
0.620 0.380 0.000
V90-V94 Water transport accidents
0.620 0.380 0.000
V70-V79 Bus occupant injured in transport accident
0.620 0.380 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.620 0.380 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.620 0.380 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.620 0.380 0.000
V01-V09 Pedestrian injured in transport accident
0.620 0.380 0.000
S81.7 Multiple open wounds of lower leg
0.620 0.380 0.000
A49.9 Bacterial infection, unspecified
0.619 0.381 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.617 0.383 0.000
Q26 Congenital malformations of great veins
0.617 0.383 0.000
Q25 Congenital malformations of great arteries
0.617 0.383 0.000
Q24 Other congenital malformations of heart
0.617 0.383 0.000
Q22 Congenital malformations of pulmonary and tricuspid valves
0.617 0.383 0.000
Q20 Congenital malformations of cardiac chambers and connexions
0.617 0.383 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.617 0.383 0.000
M25.2 Flail joint
0.616 0.384 0.000
M25.1 Fistula of joint
0.616 0.384 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.616 0.384 0.000
F60-F69 Disorders of adult personality and behaviour
0.616 0.384 0.000
T19 Foreign body in genito-urinary tract
0.615 0.385 0.000
T15 Foreign body on external eye
0.615 0.385 0.000
T16 Foreign body in ear
0.615 0.385 0.000
G98 Other disorders of nervous system, not elsewhere classified
0.615 0.385 0.000
G92 Toxic encephalopathy
0.615 0.385 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.615 0.385 0.000
M65.4 Radial styloid tenosynovitis [de Quervain]
0.615 0.385 0.000
M88 Paget's disease of bone [osteitis deformans]
0.614 0.386 0.000
H40-H42 Glaucoma
0.613 0.387 0.000
S38 Crushing injury and traumatic amputation of part of abdomen, lower back and pelvis
0.613 0.387 0.000
S37 Injury of urinary and pelvic organs
0.613 0.387 0.000
S36 Injury of intra-abdominal organs
0.613 0.387 0.000
S35 Injury of blood vessels at abdomen, lower back and pelvis level
0.613 0.387 0.000
S34 Injury of nerves and lumbar spinal cord at abdomen, lower back and pelvis level
0.613 0.387 0.000
S33 Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis
0.613 0.387 0.000
S31 Open wound of abdomen, lower back and pelvis
0.613 0.387 0.000
M83 Adult osteomalacia
0.612 0.387 0.000
G70 Myasthenia gravis and other myoneural disorders
0.612 0.388 0.000
M71 Other bursopathies
0.612 0.388 0.000
M86 Osteomyelitis
0.611 0.389 0.000
M25.9 Joint disorder, unspecified
0.611 0.389 0.000
M23.80 Other internal derangements of knee (Multiple sites)
0.611 0.389 0.000
E27 Other disorders of adrenal gland
0.611 0.389 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.611 0.389 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.611 0.389 0.000
H30-H36 Disorders of choroid and retina
0.611 0.389 0.000
S60 Superficial injury of wrist and hand
0.610 0.390 0.000
F48 Other neurotic disorders
0.610 0.390 0.000
F44 Dissociative [conversion] disorders
0.610 0.390 0.000
F80-F89 Disorders of psychological development
0.609 0.390 0.000
G96 Other disorders of central nervous system
0.609 0.391 0.000
X20-X29 Contact with venomous animals and plants
0.608 0.391 0.000
R44.1 Visual hallucinations
0.607 0.393 0.000
M92 Other juvenile osteochondrosis
0.605 0.395 0.000
M91 Juvenile osteochondrosis of hip and pelvis
0.605 0.395 0.000
G25.3 Myoclonus
0.605 0.395 0.000
M25.4 Effusion of joint
0.605 0.395 0.000
M24.9 Joint derangement, unspecified
0.604 0.396 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.604 0.396 0.000
M24.7 Protrusio acetabuli
0.604 0.396 0.000
M24.6 Ankylosis of joint
0.604 0.396 0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified
0.604 0.396 0.000
M25.86 Other specified joint disorders (Lower leg)
0.604 0.396 0.000
R46 Symptoms and signs involving appearance and behaviour
0.603 0.397 0.000
Q51 Congenital malformations of uterus and cervix
0.603 0.397 0.000
S82.60 Fracture of lateral malleolus (closed)
0.602 0.398 0.000
G40-G47 Episodic and paroxysmal disorders
0.602 0.398 0.000
F42 Obsessive-compulsive disorder
0.601 0.398 0.000
T93 Sequelae of injuries of lower limb
0.601 0.399 0.000
M84.03 Malunion of fracture (Forearm)
0.601 0.399 0.000
S42 Fracture of shoulder and upper arm
0.600 0.399 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.600 0.399 0.000
H20 Iridocyclitis
0.600 0.400 0.000
Q05 Spina bifida
0.600 0.400 0.000
S00-S09 Injuries to the head
0.599 0.401 0.000
M94 Other disorders of cartilage
0.599 0.401 0.000
G61 Inflammatory polyneuropathy
0.599 0.401 0.000
M21.24 Flexion deformity (Hand)
0.598 0.402 0.000
E23 Hypofunction and other disorders of pituitary gland
0.598 0.402 0.000
C34 Malignant neoplasm of bronchus and lung
0.598 0.402 0.000
E34 Other endocrine disorders
0.597 0.402 0.000
M84.4 Pathological fracture, not elsewhere classified
0.596 0.404 0.000
S39 Other and unspecified injuries of abdomen, lower back and pelvis
0.596 0.404 0.000
M77.9 Enthesopathy, unspecified
0.596 0.404 0.000
G71 Primary disorders of muscles
0.595 0.405 0.000
W25 Contact with sharp glass
0.595 0.405 0.000
W29 Contact with other powered hand tools and household machinery
0.595 0.405 0.000
B02 Zoster [herpes zoster]
0.595 0.405 0.000
G56.9 Mononeuropathy of upper limb, unspecified
0.595 0.405 0.000
G56.4 Causalgia
0.595 0.405 0.000
G56.3 Lesion of radial nerve
0.595 0.405 0.000
G56.1 Other lesions of median nerve
0.595 0.405 0.000
M35 Other systemic involvement of connective tissue
0.594 0.406 0.000
G95.1 Vascular myelopathies
0.594 0.406 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.594 0.406 0.000
S99 Other and unspecified injuries of ankle and foot
0.593 0.406 0.000
Q54 Hypospadias
0.593 0.407 0.000
V48 Car occupant injured in noncollision transport accident
0.593 0.407 0.000
A48 Other bacterial diseases, not elsewhere classified
0.592 0.408 0.000
A44 Bartonellosis
0.592 0.408 0.000
A43 Nocardiosis
0.592 0.408 0.000
A42 Actinomycosis
0.592 0.408 0.000
A40 Streptococcal septicaemia
0.592 0.408 0.000
A39 Meningococcal infection
0.592 0.408 0.000
A37 Whooping cough
0.592 0.408 0.000
A36 Diphtheria
0.592 0.408 0.000
A32 Listeriosis
0.592 0.408 0.000
A31 Infection due to other mycobacteria
0.592 0.408 0.000
A30 Leprosy [Hansen's disease]
0.592 0.408 0.000
A38 Scarlet fever
0.592 0.408 0.000
A35 Other tetanus
0.592 0.408 0.000
A34 Obstetrical tetanus
0.592 0.408 0.000
A33 Tetanus neonatorum
0.592 0.408 0.000
M21.1 Varus deformity, not elsewhere classified
0.592 0.408 0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.592 0.408 0.000
S79.8 Other specified injuries of hip and thigh
0.592 0.408 0.000
S79.7 Multiple injuries of hip and thigh
0.592 0.408 0.000
M76 Enthesopathies of lower limb, excluding foot
0.592 0.408 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.592 0.408 0.000
V20-V29 Motorcycle rider injured in transport accident
0.591 0.409 0.000
G51 Facial nerve disorders
0.590 0.410 0.000
T95 Sequelae of burns, corrosions and frostbite
0.590 0.410 0.000
T91 Sequelae of injuries of neck and trunk
0.590 0.410 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.590 0.410 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.590 0.410 0.000
V80-V89 Other land transport accidents
0.590 0.410 0.000
S82.9 Fracture of lower leg, part unspecified
0.590 0.410 0.000
S82.7 Multiple fractures of lower leg
0.590 0.410 0.000
S30.2 Contusion of external genital organs
0.590 0.410 0.000
G95.2 Cord compression, unspecified
0.589 0.411 0.000
B08 Other viral infections characterised by skin and mucous membrane lesions, not elsewhere classified
0.589 0.411 0.000
B06 Rubella [German measles]
0.589 0.411 0.000
B05 Measles
0.589 0.411 0.000
B01 Varicella [chickenpox]
0.589 0.411 0.000
B09 Unspecified viral infection characterised by skin and mucous membrane lesions
0.589 0.411 0.000
B04 Monkeypox
0.589 0.411 0.000
B03 Smallpox
0.589 0.411 0.000
Q27.3 Peripheral arteriovenous malformation
0.588 0.412 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.588 0.412 0.000
M23.47 Loose body in knee-Capsular lig
0.588 0.412 0.000
M23.46 Loose body in knee-O/unsp lat men
0.588 0.412 0.000
M23.45 Loose body in knee-Pst hrn lat men
0.588 0.412 0.000
M23.44 Loose body in knee-Lat lig/ant men
0.588 0.412 0.000
M23.43 Loose body in knee-Med lig/oth men
0.588 0.412 0.000
M23.42 Loose body in knee-Pst lig/hrn men
0.588 0.412 0.000
M23.41 Loose body in knee-Ant lig/hrn men
0.588 0.412 0.000
M23.40 Loose body in knee-Mult sites
0.588 0.412 0.000
M89.9 Disorder of bone, unspecified
0.588 0.412 0.000
R44.0 Auditory hallucinations
0.588 0.412 0.000
Q23 Congenital malformations of aortic and mitral valves
0.588 0.412 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.588 0.412 0.000
Q61 Cystic kidney disease
0.587 0.413 0.000
F99-F99 Unspecified mental disorder
0.587 0.413 0.000
M21.67 Other acquired deformities of ankle and foot-Ankle/foot
0.586 0.414 0.000
V10-V19 Pedal cyclist injured in transport accident
0.586 0.414 0.000
S92 Fracture of foot, except ankle
0.585 0.415 0.000
W00-W19 Falls
0.585 0.415 0.000
M25.34 Other instability of joint (Hand)
0.585 0.415 0.000
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level
0.584 0.415 0.000
Y49.5 Other antipsychotics and neuroleptics
0.584 0.416 0.000
Q28 Other congenital malformations of circulatory system
0.584 0.416 0.000
E22 Hyperfunction of pituitary gland
0.584 0.416 0.000
R23 Other skin changes
0.584 0.416 0.000
M87 Osteonecrosis
0.583 0.416 0.000
Q65 Congenital deformities of hip
0.583 0.417 0.000
E85 Amyloidosis
0.583 0.417 0.000
E84 Cystic fibrosis
0.583 0.417 0.000
E79 Disorders of purine and pyrimidine metabolism
0.583 0.417 0.000
E77 Disorders of glycoprotein metabolism
0.583 0.417 0.000
E76 Disorders of glycosaminoglycan metabolism
0.583 0.417 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.583 0.417 0.000
E74 Other disorders of carbohydrate metabolism
0.583 0.417 0.000
E72 Other disorders of amino-acid metabolism
0.583 0.417 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.583 0.417 0.000
E70 Disorders of aromatic amino-acid metabolism
0.583 0.417 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.583 0.417 0.000
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites
0.582 0.418 0.000
A49.1 Streptococcal infection, unspecified
0.581 0.419 0.000
S72.01 Fracture of neck of femur (open)
0.579 0.421 0.000
F33 Recurrent depressive disorder
0.579 0.421 0.000
G30 Alzheimer's disease
0.578 0.422 0.000
S20 Superficial injury of thorax
0.578 0.422 0.000
M77.1 Lateral epicondylitis
0.578 0.422 0.000
F02 Dementia in other diseases classified elsewhere
0.576 0.424 0.000
E73 Lactose intolerance
0.576 0.424 0.000
M75 Shoulder lesions
0.575 0.425 0.000
R81 Glycosuria
0.575 0.425 0.000
M77.5 Other enthesopathy of foot
0.575 0.425 0.000
S62 Fracture at wrist and hand level
0.575 0.425 0.000
M65.3 Trigger finger
0.575 0.425 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.574 0.426 0.000
M24.0 Loose body in joint
0.572 0.427 0.000
M85 Other disorders of bone density and structure
0.572 0.427 0.000
H03 Disorders of eyelid in diseases classified elsewhere
0.572 0.428 0.000
G91.0 Communicating hydrocephalus
0.572 0.428 0.000
S30.8 Other superficial injuries of abdomen, lower back and pelvis
0.572 0.428 0.000
M65.2 Calcific tendinitis
0.570 0.430 0.000
M65.1 Other infective (teno)synovitis
0.570 0.430 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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