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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2272593
log Bayes Factor = 170.088
Chromosome 6   position 31,601,344  (GRCh37) Explore rs2272593 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.000 1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.000 1.000
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E10.1 With ketoacidosis
0.000 0.000 1.000
H36.0 Diabetic retinopathy
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
L40.5 Arthropathic psoriasis
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.000 1.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
L40 Psoriasis
0.000 0.000 1.000
M06 Other rheumatoid arthritis
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
M05-M14 Inflammatory polyarthropathies
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
# Top node
0.000 0.000 1.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.000 0.000 1.000
E11.9 Without complications
0.000 0.000 1.000
L40-L45 Papulosquamous disorders
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.000 1.000
E10.4 With neurological complications
0.000 0.000 1.000
M05 Seropositive rheumatoid arthritis
0.000 0.000 1.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
H36 Retinal disorders in diseases classified elsewhere
0.000 0.000 1.000
H30-H36 Disorders of choroid and retina
0.000 0.000 1.000
I20 Angina pectoris
0.000 0.000 1.000
I20.9 Angina pectoris, unspecified
0.000 0.001 0.999
D64.9 Anaemia, unspecified
0.000 0.001 0.999
E83.1 Disorders of iron metabolism
0.999 0.001 0.000
M45 Ankylosing spondylitis
0.000 0.001 0.999
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.001 0.999
Chapter VII Diseases of the eye and adnexa
0.000 0.001 0.999
E14.9 Without complications
0.000 0.001 0.999
L43 Lichen planus
0.000 0.001 0.999
E11.3 With ophthalmic complications
0.000 0.001 0.999
M07 Psoriatic and enteropathic arthropathies
0.000 0.001 0.999
I22 Subsequent myocardial infarction
0.000 0.002 0.998
Chapter IX Diseases of the circulatory system
0.000 0.002 0.998
E14.3 With ophthalmic complications
0.000 0.002 0.998
M07.3 Other psoriatic arthropathies
0.000 0.002 0.998
M45-M49 Spondylopathies
0.000 0.002 0.998
L43.9 Lichen planus, unspecified
0.000 0.002 0.998
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.003 0.997
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.003 0.997
E78.0 Pure hypercholesterolaemia
0.000 0.004 0.996
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.005 0.995
E70-E90 Metabolic disorders
0.000 0.006 0.994
E10.5 With peripheral circulatory complications
0.000 0.007 0.993
G35-G37 Demyelinating diseases of the central nervous system
0.990 0.007 0.004
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.008 0.992
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.009 0.991
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.010 0.990
I21 Acute myocardial infarction
0.000 0.011 0.989
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.011 0.989
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.011 0.989
D64 Other anaemias
0.000 0.012 0.988
G37 Other demyelinating diseases of central nervous system
0.987 0.012 0.001
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.013 0.987
G37.9 Demyelinating disease of central nervous system, unspecified
0.984 0.016 0.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.017 0.983
D60-D64 Aplastic and other anaemias
0.000 0.017 0.983
M35.3 Polymyalgia rheumatica
0.000 0.017 0.983
H43-H45 Disorders of vitreous body and globe
0.000 0.018 0.982
I10-I15 Hypertensive diseases
0.000 0.018 0.982
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.019 0.981
M06.0 Seronegative rheumatoid arthritis
0.000 0.019 0.981
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.020 0.980
M35 Other systemic involvement of connective tissue
0.000 0.020 0.980
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.021 0.979
M20-M25 Other joint disorders
0.000 0.023 0.977
H43 Disorders of vitreous body
0.000 0.023 0.977
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.026 0.974
E06 Thyroiditis
0.000 0.026 0.974
E16 Other disorders of pancreatic internal secretion
0.000 0.033 0.967
I24 Other acute ischaemic heart diseases
0.000 0.033 0.967
I21.9 Acute myocardial infarction, unspecified
0.000 0.033 0.967
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.035 0.965
E05.9 Thyrotoxicosis, unspecified
0.000 0.037 0.963
E10.2 With renal complications
0.000 0.038 0.962
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.038 0.962
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.039 0.961
H34 Retinal vascular occlusions
0.000 0.040 0.960
I25.5 Ischaemic cardiomyopathy
0.000 0.041 0.959
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.042 0.958
E16.2 Hypoglycaemia, unspecified
0.000 0.044 0.956
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.044 0.956
E06.3 Autoimmune thyroiditis
0.000 0.047 0.953
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.049 0.951
I20.0 Unstable angina
0.000 0.049 0.951
I12 Hypertensive renal disease
0.000 0.051 0.949
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.060 0.940
L40.0 Psoriasis vulgaris
0.000 0.062 0.938
E11.5 With peripheral circulatory complications
0.000 0.063 0.937
M06.3 Rheumatoid nodule
0.000 0.064 0.936
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.068 0.932
E78.2 Mixed hyperlipidaemia
0.000 0.070 0.930
I12.9 Hypertensive renal disease without renal failure
0.000 0.074 0.926
E10.0 With coma
0.000 0.079 0.921
E10.8 With unspecified complications
0.000 0.085 0.915
H34.8 Other retinal vascular occlusions
0.000 0.085 0.915
E10.6 With other specified complications
0.000 0.088 0.912
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.095 0.905
H43.8 Other disorders of vitreous body
0.000 0.096 0.904
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.100 0.900
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.103 0.897
E11.1 With ketoacidosis
0.000 0.121 0.879
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.122 0.878
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.875 0.125 0.000
H43.1 Vitreous haemorrhage
0.000 0.126 0.874
H43.3 Other vitreous opacities
0.000 0.128 0.872
I15 Secondary hypertension
0.000 0.134 0.866
L43.8 Other lichen planus
0.000 0.135 0.865
M34 Systemic sclerosis
0.000 0.136 0.864
L40.8 Other psoriasis
0.000 0.142 0.858
H30 Chorioretinal inflammation
0.000 0.144 0.856
E78.8 Other disorders of lipoprotein metabolism
0.000 0.144 0.856
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.000 0.146 0.854
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.146 0.854
I10 Essential (primary) hypertension
0.000 0.147 0.853
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.161 0.839
M35.7 Hypermobility syndrome
0.000 0.171 0.829
M06.34 Rheumatoid nodule (Hand)
0.000 0.181 0.819
H43.9 Disorder of vitreous body, unspecified
0.000 0.185 0.815
H20 Iridocyclitis
0.000 0.186 0.814
G37.8 Other specified demyelinating diseases of central nervous system
0.810 0.189 0.001
I05-I09 Chronic rheumatic heart diseases
0.000 0.190 0.810
E11.2 With renal complications
0.000 0.190 0.810
M34.1 CR(E)ST syndrome
0.000 0.191 0.809
H43.2 Crystalline deposits in vitreous body
0.000 0.193 0.807
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.193 0.807
E78.4 Other hyperlipidaemia
0.000 0.195 0.805
E14.6 With other specified complications
0.000 0.198 0.802
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.199 0.801
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.199 0.801
E74 Other disorders of carbohydrate metabolism
0.000 0.199 0.801
Chapter VI Diseases of the nervous system
0.038 0.205 0.756
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.206 0.794
M14 Arthropathies in other diseases classified elsewhere
0.000 0.211 0.789
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.214 0.786
E14.5 With peripheral circulatory complications
0.000 0.215 0.785
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.222 0.778
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.224 0.776
M35.1 Other overlap syndromes
0.000 0.225 0.775
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.227 0.773
K90 Intestinal malabsorption
0.000 0.230 0.770
I25.3 Aneurysm of heart
0.000 0.232 0.768
I15.1 Hypertension secondary to other renal disorders
0.000 0.241 0.759
E11.0 With coma
0.000 0.241 0.758
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.242 0.758
H35 Other retinal disorders
0.000 0.243 0.757
M65-M68 Disorders of synovium and tendon
0.000 0.246 0.754
H30.9 Chorioretinal inflammation, unspecified
0.000 0.246 0.754
E14.1 With ketoacidosis
0.000 0.250 0.750
G50-G59 Nerve, nerve root and plexus disorders
0.003 0.251 0.746
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.253 0.747
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.253 0.747
G56.0 Carpal tunnel syndrome
0.000 0.255 0.745
G56 Mononeuropathies of upper limb
0.000 0.258 0.742
G59 Mononeuropathy in diseases classified elsewhere
0.001 0.258 0.741
E11.4 With neurological complications
0.000 0.258 0.742
H34.2 Other retinal artery occlusions
0.000 0.261 0.739
G59.0 Diabetic mononeuropathy
0.000 0.262 0.738
E89.3 Postprocedural hypopituitarism
0.000 0.262 0.738
E40-E46 Malnutrition
0.000 0.262 0.738
M30 Polyarteritis nodosa and related conditions
0.000 0.262 0.738
M49 Spondylopathies in diseases classified elsewhere
0.000 0.263 0.737
H20.9 Iridocyclitis, unspecified
0.000 0.266 0.734
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.269 0.731
M12 Other specific arthropathies
0.000 0.270 0.730
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.272 0.728
I00-I02 Acute rheumatic fever
0.000 0.274 0.726
M06.4 Inflammatory polyarthropathy
0.000 0.276 0.724
E06.5 Other chronic thyroiditis
0.000 0.276 0.724
D62 Acute posthaemorrhagic anaemia
0.000 0.276 0.724
K70-K77 Diseases of liver
0.000 0.277 0.723
H46-H48 Disorders of optic nerve and visual pathways
0.000 0.277 0.723
M65 Synovitis and tenosynovitis
0.000 0.277 0.723
G70-G73 Diseases of myoneural junction and muscle
0.008 0.278 0.714
H35.8 Other specified retinal disorders
0.000 0.278 0.722
K90-K93 Other diseases of the digestive system
0.000 0.279 0.721
E11.6 With other specified complications
0.000 0.279 0.721
H15 Disorders of sclera
0.000 0.280 0.720
H34.9 Retinal vascular occlusion, unspecified
0.000 0.280 0.720
Chapter XI Diseases of the digestive system
0.000 0.281 0.719
M25 Other joint disorders, not elsewhere classified
0.000 0.281 0.719
E78.6 Lipoprotein deficiency
0.000 0.282 0.718
H34.1 Central retinal artery occlusion
0.000 0.282 0.717
K75 Other inflammatory liver diseases
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.283 0.717
E14.8 With unspecified complications
0.000 0.283 0.717
E14.7 With multiple complications
0.000 0.283 0.717
E14.0 With coma
0.000 0.283 0.717
I25.6 Silent myocardial ischaemia
0.000 0.283 0.717
L40.4 Guttate psoriasis
0.000 0.283 0.717
L40.2 Acrodermatitis continua
0.000 0.283 0.717
L40.1 Generalised pustular psoriasis
0.000 0.283 0.717
M06.8 Other specified rheumatoid arthritis
0.000 0.283 0.717
M06.2 Rheumatoid bursitis
0.000 0.283 0.717
M06.1 Adult-onset Still's disease
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.283 0.717
M08 Juvenile arthritis
0.000 0.283 0.717
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.283 0.717
L44 Other papulosquamous disorders
0.000 0.283 0.717
L41 Parapsoriasis
0.000 0.283 0.717
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.283 0.717
M05.8 Other seropositive rheumatoid arthritis
0.000 0.283 0.717
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.283 0.717
M05.2 Rheumatoid vasculitis
0.000 0.283 0.717
M05.1 Rheumatoid lung disease
0.000 0.283 0.717
M05.0 Felty's syndrome
0.000 0.283 0.717
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.283 0.717
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.283 0.717
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.283 0.717
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.283 0.717
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.283 0.717
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
H36.8 Other retinal disorders in diseases classified elsewhere
0.000 0.283 0.717
H32 Chorioretinal disorders in diseases classified elsewhere
0.000 0.283 0.717
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.283 0.716
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.283 0.716
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.283 0.716
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.283 0.716
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.283 0.716
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.283 0.716
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.283 0.716
L43.3 Subacute (active) lichen planus
0.000 0.284 0.716
L43.2 Lichenoid drug reaction
0.000 0.284 0.716
L43.1 Bullous lichen planus
0.000 0.284 0.716
L43.0 Hypertrophic lichen planus
0.000 0.284 0.716
M07.6 Other enteropathic arthropathies
0.000 0.284 0.716
M07.5 Arthropathy in ulcerative colitis
0.000 0.284 0.716
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.284 0.716
M07.2 Psoriatic spondylitis
0.000 0.284 0.716
M07.1 Arthritis mutilans
0.000 0.284 0.716
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.284 0.716
M07.38 Other psoriatic arthropathies (Other)
0.000 0.285 0.715
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.285 0.715
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.285 0.715
E05.5 Thyroid crisis or storm
0.000 0.285 0.715
E05.4 Thyrotoxicosis factitia
0.000 0.285 0.715
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.285 0.715
K75.4 Autoimmune hepatitis
0.000 0.285 0.715
E79 Disorders of purine and pyrimidine metabolism
0.000 0.286 0.714
E78.3 Hyperchylomicronaemia
0.000 0.287 0.713
E77 Disorders of glycoprotein metabolism
0.000 0.287 0.713
E76 Disorders of glycosaminoglycan metabolism
0.000 0.287 0.713
E72 Other disorders of amino-acid metabolism
0.000 0.287 0.713
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.287 0.713
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.287 0.713
I08 Multiple valve diseases
0.000 0.288 0.712
G36 Other acute disseminated demyelination
0.709 0.288 0.003
I23 Certain current complications following acute myocardial infarction
0.000 0.289 0.711
M35.2 Behcet's disease
0.000 0.289 0.711
E89.0 Postprocedural hypothyroidism
0.000 0.290 0.710
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.291 0.709
M25.4 Effusion of joint
0.000 0.291 0.709
D64.4 Congenital dyserythropoietic anaemia
0.000 0.291 0.708
D64.3 Other sideroblastic anaemias
0.000 0.291 0.708
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.000 0.291 0.708
D64.1 Secondary sideroblastic anaemia due to disease
0.000 0.291 0.708
D64.0 Hereditary sideroblastic anaemia
0.000 0.291 0.708
G37.5 Concentric sclerosis [Balo]
0.707 0.292 0.001
G37.4 Subacute necrotising myelitis
0.707 0.292 0.001
G37.2 Central pontine myelinolysis
0.707 0.292 0.001
G37.1 Central demyelination of corpus callosum
0.707 0.292 0.001
G37.0 Diffuse sclerosis
0.707 0.292 0.001
M33 Dermatopolymyositis
0.000 0.293 0.707
M24 Other specific joint derangements
0.000 0.294 0.706
E13 Other specified diabetes mellitus
0.000 0.295 0.705
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.295 0.705
H45 Disorders of vitreous body and globe in diseases classified elsewhere
0.000 0.296 0.704
E15 Nondiabetic hypoglycaemic coma
0.000 0.297 0.703
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.297 0.703
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.297 0.703
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.297 0.703
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.297 0.703
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.297 0.703
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.297 0.703
K74 Fibrosis and cirrhosis of liver
0.000 0.297 0.703
M35.9 Systemic involvement of connective tissue, unspecified
0.000 0.297 0.702
M35.6 Relapsing panniculitis [Weber-Christian]
0.000 0.297 0.702
M35.5 Multifocal fibrosclerosis
0.000 0.297 0.702
M35.4 Diffuse (eosinophilic) fasciitis
0.000 0.297 0.702
M25.46 Effusion of joint (Lower leg)
0.000 0.298 0.702
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.000 0.299 0.701
E86 Volume depletion
0.000 0.299 0.701
E70 Disorders of aromatic amino-acid metabolism
0.000 0.301 0.699
E06.4 Drug-induced thyroiditis
0.000 0.302 0.698
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.302 0.698
E06.1 Subacute thyroiditis
0.000 0.302 0.698
E06.0 Acute thyroiditis
0.000 0.302 0.698
D61 Other aplastic anaemias
0.000 0.305 0.695
E06.9 Thyroiditis, unspecified
0.000 0.306 0.693
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.307 0.693
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.307 0.693
E16.4 Abnormal secretion of gastrin
0.000 0.307 0.693
E16.3 Increased secretion of glucagon
0.000 0.307 0.693
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.307 0.693
M14.6 Neuropathic arthropathy
0.000 0.308 0.692
H20.0 Acute and subacute iridocyclitis
0.000 0.308 0.692
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.000 0.308 0.692
K74.3 Primary biliary cirrhosis
0.000 0.312 0.688
H34.0 Transient retinal artery occlusion
0.000 0.312 0.688
H19 Disorders of sclera and cornea in diseases classified elsewhere
0.000 0.317 0.683
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.318 0.682
H35.4 Peripheral retinal degeneration
0.000 0.320 0.680
M65.4 Radial styloid tenosynovitis [de Quervain]
0.000 0.321 0.679
E11.8 With unspecified complications
0.000 0.322 0.678
I15.9 Seconday hypertension, unspecified
0.000 0.322 0.678
H43.0 Vitreous prolapse
0.000 0.322 0.678
H40-H42 Glaucoma
0.000 0.323 0.677
E14.2 Withrenal complications
0.000 0.325 0.674
I12.0 Hypertensive renal disease with renal failure
0.000 0.325 0.675
E07 Other disorders of thyroid
0.000 0.326 0.674
I24.8 Other forms of acute ischaemic heart disease
0.000 0.326 0.674
G90-G99 Other disorders of the nervous system
0.005 0.327 0.668
E14.4 With neurological complications
0.000 0.329 0.671
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.329 0.671
M06.38 Rheumatoid nodule (Other)
0.000 0.329 0.671
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.329 0.671
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.329 0.671
M06.33 Rheumatoid nodule (Forearm)
0.000 0.329 0.671
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.329 0.671
H55-H59 Other disorders of eye and adnexa
0.000 0.330 0.670
E78.1 Pure hyperglyceridaemia
0.000 0.332 0.668
L10-L14 Bullous disorders
0.000 0.333 0.666
E89.4 Postprocedural ovarian failure
0.000 0.337 0.663
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.337 0.663
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.338 0.662
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.339 0.661
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.005 0.339 0.656
L42 Pityriasis rosea
0.000 0.340 0.660
I13 Hypertensive heart and renal disease
0.000 0.340 0.660
I09 Other rheumatic heart diseases
0.000 0.341 0.659
D63 Anaemia in chronic diseases classified elsewhere
0.000 0.344 0.656
H20.8 Other iridocyclitis
0.000 0.345 0.655
K72 Hepatic failure, not elsewhere classified
0.000 0.347 0.653
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.348 0.652
I22.8 Subsequent myocardial infarction of other sites
0.000 0.348 0.652
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.348 0.651
K74.5 Biliary cirrhosis, unspecified
0.000 0.350 0.650
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.000 0.350 0.650
H22 Disorders of iris and ciliary body in diseases classified elsewhere
0.000 0.350 0.650
E89.2 Postprocedural hypoparathyroidism
0.000 0.352 0.648
E84 Cystic fibrosis
0.000 0.355 0.645
D55-D59 Haemolytic anaemias
0.000 0.357 0.643
G91 Hydrocephalus
0.002 0.361 0.637
H33 Retinal detachments and breaks
0.000 0.365 0.635
D50-D53 Nutritional anaemias
0.000 0.366 0.634
M25.6 Stiffness of joint, not elsewhere classified
0.000 0.366 0.634
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.368 0.631
E73 Lactose intolerance
0.000 0.370 0.630
H21 Other disorders of iris and ciliary body
0.000 0.370 0.630
M65.8 Other synovitis and tenosynovitis
0.000 0.370 0.630
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.370 0.629
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.370 0.629
E89.5 Postprocedural testicular hypofunction
0.000 0.370 0.629
E89.1 Postprocedural hypoinsulinaemia
0.000 0.370 0.629
I25.4 Coronary artery aneurysm
0.000 0.371 0.629
G91.9 Hydrocephalus, unspecified
0.000 0.372 0.628
G72 Other myopathies
0.003 0.373 0.624
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.626 0.373 0.001
E88 Other metabolic disorders
0.000 0.378 0.622
M80-M85 Disorders of bone density and structure
0.000 0.379 0.621
I15.8 Other secondary hypertension
0.000 0.379 0.621
I15.2 Hypertension secondary to endocrine disorders
0.000 0.379 0.621
I15.0 Renovascular hypertension
0.000 0.379 0.621
E03.8 Other specified hypothyroidism
0.000 0.379 0.621
M34.2 Systemic sclerosis induced by drugs and chemicals
0.000 0.380 0.620
I08.0 Disorders of both mitral and aortic valves
0.000 0.381 0.619
M00-M03 Infectious arthropathies
0.000 0.382 0.618
M65.43 Radial styloid tenosynovitis [de Quervain] (Forearm)
0.000 0.383 0.617
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.384 0.615
L56 Other acute skin changes due to ultraviolet radiation
0.000 0.385 0.615
M24.6 Ankylosis of joint
0.000 0.386 0.614
H30.8 Other chorioretinal inflammations
0.000 0.386 0.614
H30.2 Posterior cyclitis
0.000 0.386 0.614
H30.1 Disseminated chorioretinal inflammation
0.000 0.386 0.614
H30.0 Focal chorioretinal inflammation
0.000 0.386 0.614
G70 Myasthenia gravis and other myoneural disorders
0.004 0.387 0.610
I24.1 Dressler's syndrome
0.000 0.388 0.611
M24.0 Loose body in joint
0.000 0.390 0.610
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.391 0.609
E16.1 Other hypoglycaemia
0.000 0.392 0.608
K73 Chronic hepatitis, not elsewhere classified
0.000 0.392 0.608
E83 Disorders of mineral metabolism
0.490 0.393 0.117
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.393 0.607
H33.2 Serous retinal detachment
0.000 0.396 0.604
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.000 0.399 0.601
M32 Systemic lupus erythematosus
0.000 0.399 0.600
M35.8 Other specified systemic involvement of connective tissue
0.000 0.401 0.599
M34.0 Progressive systemic sclerosis
0.000 0.401 0.599
G53 Cranial nerve disorders in diseases classified elsewhere
0.002 0.401 0.597
K72.9 Hepatic failure, unspecified
0.000 0.402 0.598
H15.1 Episcleritis
0.000 0.404 0.596
M25.40 Effusion of joint (Multiple sites)
0.000 0.404 0.596
M24.1 Other articular cartilage disorders
0.000 0.405 0.595
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)
0.000 0.406 0.594
G52 Disorders of other cranial nerves
0.002 0.408 0.590
M24.7 Protrusio acetabuli
0.000 0.409 0.591
E03.1 Congenital hypothyroidism without goitre
0.000 0.410 0.590
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.411 0.589
G56.1 Other lesions of median nerve
0.000 0.411 0.589
M65.84 Other synovitis and tenosynovitis (Hand)
0.000 0.412 0.588
I83 Varicose veins of lower extremities
0.588 0.412 0.000
M34.9 Systemic sclerosis, unspecified
0.000 0.414 0.586
M91-M94 Chondropathies
0.000 0.414 0.586
E50-E64 Other nutritional deficiencies
0.000 0.416 0.584
M70-M79 Other soft tissue disorders
0.000 0.416 0.584
H20.2 Lens-induced iridocyclitis
0.000 0.417 0.583
G71 Primary disorders of muscles
0.004 0.417 0.579
H20.1 Chronic iridocyclitis
0.000 0.417 0.583
K75.9 Inflammatory liver disease, unspecified
0.000 0.417 0.583
M82 Osteoporosis in diseases classified elsewhere
0.000 0.419 0.581
D61.1 Drug-induced aplastic anaemia
0.000 0.419 0.581
M65.44 Radial styloid tenosynovitis [de Quervain] (Hand)
0.000 0.420 0.580
G56.9 Mononeuropathy of upper limb, unspecified
0.000 0.421 0.579
L40.3 Pustulosis palmaris et plantaris
0.000 0.422 0.577
H15.8 Other disorders of sclera
0.000 0.422 0.578
L50-L54 Urticaria and erythema
0.000 0.423 0.577
H35.2 Other proliferative retinopathy
0.000 0.423 0.577
H59 Postprocedural disorders of eye and adnexa, not elsewhere classified
0.000 0.424 0.576
G94 Other disorders of brain in diseases classified elsewhere
0.003 0.424 0.573
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.426 0.574
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.426 0.574
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.426 0.574
E74.2 Disorders of galactose metabolism
0.000 0.426 0.574
E74.1 Disorders of fructose metabolism
0.000 0.426 0.574
E74.0 Glycogen storage disease
0.000 0.426 0.574
M34.8 Other forms of systemic sclerosis
0.000 0.426 0.573
M12.3 Palindromic rheumatism
0.000 0.427 0.573
M13 Other arthritis
0.000 0.429 0.571
G56.3 Lesion of radial nerve
0.000 0.432 0.567
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.433 0.567
I07 Rheumatic tricuspid valve diseases
0.000 0.434 0.566
G63 Polyneuropathy in diseases classified elsewhere
0.002 0.434 0.564
M14.5 Arthropathies in other endocrine, nutritional and metabolic disorders
0.000 0.434 0.566
M14.4 Arthropathy in amyloidosis
0.000 0.434 0.566
M14.3 Lipoid dermatoarthritis
0.000 0.434 0.566
M14.1 Crystal arthropathy in other metabolic disorders
0.000 0.434 0.566
M14.0 Gouty arthropathy due to enzyme defects and other inherited disorders
0.000 0.434 0.566
G56.4 Causalgia
0.000 0.438 0.562
M80 Osteoporosis with pathological fracture
0.000 0.439 0.561
M60-M63 Disorders of muscles
0.000 0.440 0.559
G61 Inflammatory polyneuropathy
0.002 0.441 0.557
M30.0 Polyarteritis nodosa
0.000 0.442 0.558
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.443 0.556
M11 Other crystal arthropathies
0.000 0.446 0.554
I08.1 Disorders of both mitral and tricuspid valves
0.000 0.446 0.554
M70 Soft tissue disorders related to use, overuse and pressure
0.000 0.447 0.553
K90.3 Pancreatic steatorrhoea
0.000 0.448 0.552
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.448 0.552
K90.1 Tropical sprue
0.000 0.448 0.552
M82.1 Osteoporosis in endocrine disorders
0.000 0.448 0.552
I09.9 Rheumatic heart disease, unspecified
0.000 0.449 0.551
E46 Unspecified protein-energy malnutrition
0.000 0.450 0.550
M49.5 Collapsed vertebra in diseases classified elsewhere
0.000 0.450 0.549
H35.6 Retinal haemorrhage
0.000 0.452 0.548
K75.3 Granulomatous hepatitis, not elsewhere classified
0.000 0.454 0.546
H19.1 Herpesviral keratitis and keratoconjunctivitis
0.000 0.455 0.545
D64.8 Other specified anaemias
0.000 0.456 0.544
H35.1 Retinopathy of prematurity
0.000 0.457 0.543
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.000 0.460 0.540
M80.9 Unspecified osteoporosis with pathological fracture
0.000 0.460 0.540
M35.0 Sicca syndrome [Sjogren]
0.000 0.460 0.540
M77 Other enthesopathies
0.000 0.461 0.539
H17 Corneal scars and opacities
0.000 0.462 0.538
M30.1 Polyarteritis with lung involvement [Churg-Strauss]
0.000 0.462 0.538
M25.47 Effusion of joint (Ankle and foot)
0.000 0.463 0.537
M24.02 Loose body in joint (Upper arm)
0.000 0.463 0.537
G96 Other disorders of central nervous system
0.002 0.464 0.534
M65.9 Synovitis and tenosynovitis, unspecified
0.000 0.464 0.536
E80.6 Other disorders of bilirubin metabolism
0.000 0.464 0.536
M25.43 Effusion of joint (Forearm)
0.000 0.466 0.534
E80.2 Other porphyria
0.000 0.467 0.533
G59.8 Other mononeuropathies in diseases classified elsewhere
0.001 0.468 0.531
G72.0 Drug-induced myopathy
0.001 0.468 0.531
I11 Hypertensive heart disease
0.000 0.468 0.532
I83.0 Varicose veins of lower extremities with ulcer
0.532 0.468 0.000
M33.1 Other dermatomyositis
0.000 0.468 0.531
I00 Rheumatic fever without mention of heart involvement
0.000 0.469 0.531
G98 Other disorders of nervous system, not elsewhere classified
0.003 0.469 0.528
G70.0 Myasthenia gravis
0.001 0.470 0.529

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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