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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3828912
log Bayes Factor = 65.0089
Chromosome 6   position 31,465,726  (GRCh37) Explore rs3828912 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
K90.0 Coeliac disease
0.000 0.000 1.000
M45.X9 Ankylosing spondylitis (Site unspecified)
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
0.000 0.001 0.999
M45 Ankylosing spondylitis
0.999 0.001 0.000
R31 Unspecified haematuria
0.998 0.002 0.000
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.997 0.003 0.000
E10-E14 Diabetes mellitus
0.000 0.006 0.994
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.006 0.994
E05.9 Thyrotoxicosis, unspecified
0.000 0.009 0.991
E00-E07 Disorders of thyroid gland
0.000 0.010 0.990
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.010 0.990
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.019 0.981
E10.2 With renal complications
0.000 0.023 0.977
E10.9 Without complications
0.000 0.025 0.975
E10.3 With ophthalmic complications
0.000 0.037 0.963
G35 Multiple sclerosis
0.000 0.042 0.958
M45.X2 Ankylosing spondylitis (Cervical region)
0.951 0.049 0.000
I25 Chronic ischaemic heart disease
0.942 0.058 0.000
I20-I25 Ischaemic heart diseases
0.939 0.061 0.000
E10.1 With ketoacidosis
0.000 0.061 0.939
I20 Angina pectoris
0.938 0.062 0.000
I25.1 Atherosclerotic heart disease
0.935 0.065 0.000
I20.0 Unstable angina
0.931 0.069 0.000
K90 Intestinal malabsorption
0.000 0.070 0.930
E10.4 With neurological complications
0.000 0.081 0.919
K90.9 Intestinal malabsorption, unspecified
0.000 0.088 0.912
E20-E35 Disorders of other endocrine glands
0.000 0.088 0.912
E27 Other disorders of adrenal gland
0.000 0.093 0.907
I24 Other acute ischaemic heart diseases
0.898 0.102 0.000
E50-E64 Other nutritional deficiencies
0.000 0.110 0.890
I20.9 Angina pectoris, unspecified
0.889 0.111 0.000
E27.1 Primary adrenocortical insufficiency
0.000 0.112 0.888
I25.9 Chronic ischaemic heart disease, unspecified
0.867 0.133 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.136 0.864
E10.8 With unspecified complications
0.000 0.137 0.863
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.855 0.145 0.000
E05.8 Other thyrotoxicosis
0.000 0.146 0.854
I25.5 Ischaemic cardiomyopathy
0.851 0.149 0.000
G37 Other demyelinating diseases of central nervous system
0.000 0.153 0.847
E11 Non-insulin-dependent diabetes mellitus
0.000 0.154 0.846
M45.X6 Ankylosing spondylitis (Lumbar region)
0.840 0.160 0.000
G37.9 Demyelinating disease of central nervous system, unspecified
0.000 0.162 0.838
I20.1 Angina pectoris with documented spasm
0.821 0.179 0.000
E10.5 With peripheral circulatory complications
0.000 0.184 0.816
E06 Thyroiditis
0.000 0.184 0.816
E10.6 With other specified complications
0.000 0.188 0.812
E11.5 With peripheral circulatory complications
0.000 0.188 0.812
E27.8 Other specified disorders of adrenal gland
0.000 0.195 0.805
E53 Deficiency of other B group vitamins
0.000 0.206 0.794
I25.2 Old myocardial infarction
0.786 0.214 0.000
E61 Deficiency of other nutrient elements
0.000 0.219 0.781
I24.8 Other forms of acute ischaemic heart disease
0.777 0.223 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.231 0.768
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.240 0.760
I23 Certain current complications following acute myocardial infarction
0.750 0.250 0.000
E07 Other disorders of thyroid
0.000 0.259 0.741
E34 Other endocrine disorders
0.000 0.259 0.741
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.261 0.739
E20 Hypoparathyroidism
0.000 0.262 0.738
E27.2 Addisonian crisis
0.000 0.267 0.733
E06.9 Thyroiditis, unspecified
0.000 0.277 0.723
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.280 0.720
E14 Unspecified diabetes mellitus
0.000 0.281 0.719
E10.7 With multiple complications
0.000 0.283 0.716
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.716 0.284 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.716 0.284 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.716 0.284 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.716 0.284 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.716 0.284 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.716 0.284 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.284 0.716
E12 Malnutrition-related diabetes mellitus
0.000 0.287 0.713
E05.5 Thyroid crisis or storm
0.000 0.287 0.713
E05.4 Thyrotoxicosis factitia
0.000 0.287 0.713
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.287 0.713
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.287 0.713
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.290 0.710
E00 Congenital iodine-deficiency syndrome
0.000 0.290 0.710
I25.8 Other forms of chronic ischaemic heart disease
0.703 0.297 0.000
I25.4 Coronary artery aneurysm
0.703 0.297 0.000
E53.8 Deficiency of other specified B group vitamins
0.000 0.302 0.698
E11.4 With neurological complications
0.000 0.307 0.693
I25.6 Silent myocardial ischaemia
0.687 0.313 0.000
E61.1 Iron deficiency
0.000 0.319 0.681
E40-E46 Malnutrition
0.000 0.326 0.674
E11.3 With ophthalmic complications
0.000 0.328 0.672
K90.3 Pancreatic steatorrhoea
0.000 0.333 0.667
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.333 0.667
K90.1 Tropical sprue
0.000 0.333 0.667
E11.6 With other specified complications
0.000 0.335 0.664
K90.8 Other intestinal malabsorption
0.000 0.343 0.657
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.346 0.654
E32 Diseases of thymus
0.000 0.346 0.654
E31 Polyglandular dysfunction
0.000 0.346 0.654
E30 Disorders of puberty, not elsewhere classified
0.000 0.346 0.654
E27.5 Adrenomedullary hyperfunction
0.000 0.350 0.650
E27.0 Other adrenocortical overactivity
0.000 0.350 0.650
E25 Adrenogenital disorders
0.000 0.351 0.648
E51 Thiamine deficiency
0.000 0.357 0.643
I24.9 Acute ischaemic heart disease, unspecified
0.640 0.360 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.360 0.640
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.362 0.638
E63 Other nutritional deficiencies
0.000 0.362 0.638
E50 Vitamin A deficiency
0.000 0.362 0.638
E60 Dietary zinc deficiency
0.000 0.362 0.638
E59 Dietary selenium deficiency
0.000 0.362 0.638
E54 Ascorbic acid deficiency
0.000 0.362 0.638
E52 Niacin deficiency [pellagra]
0.000 0.362 0.638
E53.9 Vitamin B deficiency, unspecified
0.000 0.367 0.633
E10.0 With coma
0.000 0.380 0.620
I23.8 Other current complications following acute myocardial infarction
0.614 0.386 0.000
E20.9 Hypoparathyroidism, unspecified
0.000 0.387 0.613
E07.9 Disorder of thyroid, unspecified
0.000 0.387 0.613
E56 Other vitamin deficiencies
0.000 0.389 0.611
E11.1 With ketoacidosis
0.000 0.389 0.611
E61.2 Magnesium deficiency
0.000 0.391 0.608
G37.5 Concentric sclerosis [Balo]
0.000 0.393 0.607
G37.4 Subacute necrotising myelitis
0.000 0.393 0.607
G37.2 Central pontine myelinolysis
0.000 0.393 0.607
G37.1 Central demyelination of corpus callosum
0.000 0.393 0.607
G37.0 Diffuse sclerosis
0.000 0.393 0.607
E14.3 With ophthalmic complications
0.000 0.393 0.607
E11.7 With multiple complications
0.000 0.393 0.607
E34.9 Endocrine disorder, unspecified
0.000 0.394 0.606
G36 Other acute disseminated demyelination
0.000 0.395 0.605
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.395 0.605
I25.3 Aneurysm of heart
0.597 0.403 0.000
E11.8 With unspecified complications
0.000 0.407 0.593
E06.4 Drug-induced thyroiditis
0.000 0.415 0.585
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.415 0.585
E06.1 Subacute thyroiditis
0.000 0.415 0.585
E06.0 Acute thyroiditis
0.000 0.415 0.585
E58 Dietary calcium deficiency
0.000 0.423 0.576
E14.1 With ketoacidosis
0.000 0.425 0.575
G37.8 Other specified demyelinating diseases of central nervous system
0.000 0.425 0.575
E27.9 Disorder of adrenal gland, unspecified
0.000 0.426 0.574
E55 Vitamin D deficiency
0.000 0.428 0.572
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.429 0.571
E53.1 Pyridoxine deficiency
0.000 0.431 0.569
E53.0 Riboflavin deficiency
0.000 0.431 0.569
E14.5 With peripheral circulatory complications
0.000 0.436 0.564
E61.9 Deficiency of nutrient element, unspecified
0.000 0.440 0.560
E61.8 Deficiency of other specified nutrient elements
0.000 0.440 0.560
E61.7 Deficiency of multiple nutrient elements
0.000 0.440 0.560
E61.6 Vanadium deficiency
0.000 0.440 0.560
E61.5 Molybdenum deficiency
0.000 0.440 0.560
E61.4 Chromium deficiency
0.000 0.440 0.560
E61.3 Manganese deficiency
0.000 0.440 0.560
E61.0 Copper deficiency
0.000 0.440 0.560
E29 Testicular dysfunction
0.000 0.441 0.559
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.447 0.553
E21.0 Primary hyperparathyroidism
0.000 0.451 0.549
E06.5 Other chronic thyroiditis
0.000 0.452 0.548
E06.3 Autoimmune thyroiditis
0.000 0.452 0.548
E34.8 Other specified endocrine disorders
0.000 0.455 0.545
E13 Other specified diabetes mellitus
0.000 0.459 0.541
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.537 0.462 0.000
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.537 0.462 0.000
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.537 0.462 0.000
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.537 0.462 0.000
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.537 0.462 0.000
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.537 0.462 0.000
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.537 0.462 0.000
E34.0 Carcinoid syndrome
0.000 0.463 0.536
E14.6 With other specified complications
0.000 0.465 0.535
E07.1 Dyshormogenetic goitre
0.000 0.468 0.532
E07.0 Hypersecretion of calcitonin
0.000 0.468 0.532
E34.5 Androgen resistance syndrome
0.000 0.469 0.531
E34.4 Constitutional tall stature
0.000 0.469 0.531
E34.3 Short stature, not elsewhere classified
0.000 0.469 0.531
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.469 0.531
E34.1 Other hypersecretion of intestinal hormones
0.000 0.469 0.531
E14.8 With unspecified complications
0.000 0.469 0.531
E26 Hyperaldosteronism
0.000 0.469 0.530
E20.8 Other hypoparathyroidism
0.000 0.471 0.529
E20.1 Pseudohypoparathyroidism
0.000 0.471 0.529
E20.0 Idiopathic hypoparathyroidism
0.000 0.471 0.529
E24 Cushing's syndrome
0.000 0.472 0.528
I24.1 Dressler's syndrome
0.527 0.473 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.524 0.476 0.000
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.477 0.523
E14.7 With multiple complications
0.000 0.484 0.515
E14.2 Withrenal complications
0.000 0.484 0.515
E14.0 With coma
0.000 0.484 0.515
E21.4 Other specified disorders of parathyroid gland
0.000 0.486 0.514
E12.9 Without complications
0.000 0.489 0.511
E12.8 With unspecified complications
0.000 0.489 0.511
E12.7 With multiple complications
0.000 0.489 0.511
E12.6 With other specified complications
0.000 0.489 0.511
E12.5 With peripheral circulatory complications
0.000 0.489 0.511
E12.4 With neurological complications
0.000 0.489 0.511
E12.3 With ophthalmic complications
0.000 0.489 0.511
E12.2 With renal complications
0.000 0.489 0.511
E12.1 With ketoacidosis
0.000 0.489 0.511
E12.0 With coma
0.000 0.489 0.511
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.491 0.509
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.491 0.509
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.491 0.509
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.491 0.509
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.491 0.509
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.491 0.509
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.491 0.509
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.491 0.509
E21.2 Other hyperparathyroidism
0.000 0.509 0.491
I22 Subsequent myocardial infarction
0.487 0.513 0.000
E14.4 With neurological complications
0.000 0.514 0.486
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.516 0.484
E45 Retarded development following protein-energy malnutrition
0.000 0.516 0.484
E43 Unspecified severe protein-energy malnutrition
0.000 0.516 0.484
E42 Marasmic kwashiorkor
0.000 0.516 0.484
E41 Nutritional marasmus
0.000 0.516 0.484
E40 Kwashiorkor
0.000 0.516 0.484
E11.2 With renal complications
0.000 0.517 0.482
E30.9 Disorder of puberty, unspecified
0.000 0.531 0.469
E30.8 Other disorders of puberty
0.000 0.531 0.469
E30.1 Precocious puberty
0.000 0.531 0.469
E30.0 Delayed puberty
0.000 0.531 0.469
E31.9 Polyglandular dysfunction, unspecified
0.000 0.531 0.469
E31.8 Other polyglandular dysfunction
0.000 0.531 0.469
E31.1 Polyglandular hyperfunction
0.000 0.531 0.469
E31.0 Autoimmune polyglandular failure
0.000 0.531 0.469
E32.9 Disease of thymus, unspecified
0.000 0.531 0.469
E32.8 Other diseases of thymus
0.000 0.531 0.469
E32.1 Abscess of thymus
0.000 0.531 0.469
E32.0 Persistent hyperplasia of thymus
0.000 0.531 0.469
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.531 0.469
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.531 0.469
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.531 0.469
E51.2 Wernicke's encephalopathy
0.000 0.535 0.465
E25.9 Adrenogenital disorder, unspecified
0.000 0.535 0.465
E25.8 Other adrenogenital disorders
0.000 0.535 0.465
E51.9 Thiamine deficiency, unspecified
0.000 0.539 0.461
E51.8 Other manifestations of thiamine deficiency
0.000 0.539 0.461
E51.1 Beriberi
0.000 0.539 0.461
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.540 0.460
I21 Acute myocardial infarction
0.460 0.540 0.000
E50.9 Vitamin A deficiency, unspecified
0.000 0.542 0.458
E50.8 Other manifestations of vitamin A deficiency
0.000 0.542 0.458
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.542 0.458
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.542 0.458
E50.5 Vitamin A deficiency with night blindness
0.000 0.542 0.458
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.542 0.458
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.542 0.458
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.542 0.458
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.542 0.458
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.542 0.458
E63.9 Nutritional deficiency, unspecified
0.000 0.542 0.458
E63.8 Other specified nutritional deficiencies
0.000 0.542 0.458
E63.1 Imbalance of constituents of food intake
0.000 0.542 0.458
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.542 0.458
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.542 0.458
E64.8 Sequelae of other nutritional deficiencies
0.000 0.542 0.458
E64.3 Sequelae of rickets
0.000 0.542 0.458
E64.2 Sequelae of vitamin C deficiency
0.000 0.542 0.458
E64.1 Sequelae of vitamin A deficiency
0.000 0.542 0.458
E64.0 Sequelae of protein-energy malnutrition
0.000 0.542 0.458
E07.8 Other specified disorders of thyroid
0.000 0.549 0.451
I21.2 Acute transmural myocardial infarction of other sites
0.449 0.551 0.000
E46 Unspecified protein-energy malnutrition
0.000 0.551 0.448
I22.1 Subsequent myocardial infarction of inferior wall
0.444 0.556 0.000
E56.9 Vitamin deficiency, unspecified
0.000 0.562 0.438
E56.8 Deficiency of other vitamins
0.000 0.562 0.438
E56.0 Deficiency of vitamin E
0.000 0.562 0.438
G36.9 Acute disseminated demyelination, unspecified
0.000 0.566 0.433
G36.8 Other specified acute disseminated demyelination
0.000 0.566 0.433
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.000 0.566 0.433
E21.3 Hyperparathyroidism, unspecified
0.000 0.574 0.426
G36.0 Neuromyelitis optica [Devic]
0.000 0.581 0.418
E28 Ovarian dysfunction
0.000 0.583 0.417
E56.1 Deficiency of vitamin K
0.000 0.588 0.411
E55.0 Rickets, active
0.000 0.590 0.410
E29.9 Testicular dysfunction, unspecified
0.000 0.599 0.401
E29.8 Other testicular dysfunction
0.000 0.599 0.401
E29.0 Testicular hyperfunction
0.000 0.599 0.401
E15 Nondiabetic hypoglycaemic coma
0.000 0.603 0.397
E11.0 With coma
0.000 0.610 0.390
E13.8 With unspecified complications
0.000 0.612 0.388
E13.7 With multiple complications
0.000 0.612 0.388
E13.6 With other specified complications
0.000 0.612 0.388
E13.5 With peripheral circulatory complications
0.000 0.612 0.388
E13.4 With neurological complications
0.000 0.612 0.388
E13.2 With renal complications
0.000 0.612 0.388
E13.1 With ketoacidosis
0.000 0.612 0.388
E13.0 With coma
0.000 0.612 0.388
E13.3 With ophthalmic complications
0.000 0.612 0.388
E22 Hyperfunction of pituitary gland
0.000 0.618 0.382
E26.8 Other hyperaldosteronism
0.000 0.619 0.380
E26.1 Secondary hyperaldosteronism
0.000 0.619 0.380
E24.8 Other Cushing's syndrome
0.000 0.621 0.379
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.621 0.379
E24.3 Ectopic ACTH syndrome
0.000 0.621 0.379
E24.1 Nelson's syndrome
0.000 0.621 0.379
R30.0 Dysuria
0.379 0.621 0.000
R30-R39 Symptoms and signs involving the urinary system
0.375 0.625 0.000
R30 Pain associated with micturition
0.373 0.627 0.000
E24.0 Pituitary-dependent Cushing's disease
0.000 0.634 0.366
E26.9 Hyperaldosteronism, unspecified
0.000 0.635 0.365
E44.1 Mild protein-energy malnutrition
0.000 0.653 0.347
E44.0 Moderate protein-energy malnutrition
0.000 0.653 0.347
R34 Anuria and oliguria
0.345 0.655 0.000
E55.9 Vitamin D deficiency, unspecified
0.000 0.656 0.344
E24.2 Drug-induced Cushing's syndrome
0.000 0.657 0.343
E65-E68 Obesity and other hyperalimentation
0.000 0.665 0.335
I21.9 Acute myocardial infarction, unspecified
0.334 0.666 0.000
I21.X Presumed acute myicardial infaction (unconfirmed)
0.330 0.670 0.000
E24.9 Cushing's syndrome, unspecified
0.000 0.677 0.323
E29.1 Testicular hypofunction
0.000 0.694 0.306
E23 Hypofunction and other disorders of pituitary gland
0.000 0.697 0.303
E28.9 Ovarian dysfunction, unspecified
0.000 0.700 0.299
E28.8 Other ovarian dysfunction
0.000 0.700 0.299
E28.1 Androgen excess
0.000 0.700 0.299
E28.0 Oestrogen excess
0.000 0.700 0.299
M25.55 Pain in joint (Pelvic region and thigh)
0.000 0.714 0.286
E03 Other hypothyroidism
0.001 0.717 0.282
E26.0 Primary hyperaldosteronism
0.000 0.717 0.282
E28.3 Primary ovarian failure
0.000 0.724 0.276
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.726 0.274
E22.8 Other hyperfunction of pituitary gland
0.000 0.726 0.274
M25.5 Pain in joint
0.000 0.726 0.274
M25.54 Pain in joint (Hand)
0.000 0.727 0.273
I22.8 Subsequent myocardial infarction of other sites
0.272 0.728 0.000
R30.1 Vesical tenesmus
0.270 0.730 0.000
I20.8 Other forms of angina pectoris
0.252 0.748 0.000
I21.3 Acute transmural myocardial infarction of unspecified site
0.248 0.751 0.000
M25.53 Pain in joint (Forearm)
0.000 0.754 0.245
R36 Urethral discharge
0.245 0.755 0.000
M25 Other joint disorders, not elsewhere classified
0.000 0.755 0.245
M25.6 Stiffness of joint, not elsewhere classified
0.000 0.759 0.241
E16 Other disorders of pancreatic internal secretion
0.000 0.760 0.240
E22.1 Hyperprolactinaemia
0.000 0.760 0.240
E67 Other hyperalimentation
0.000 0.760 0.240
E68 Sequelae of hyperalimentation
0.000 0.760 0.240
M25.7 Osteophyte
0.000 0.763 0.237
M25.61 Stiffness of joint, not elsewhere classified (Shoulder region)
0.000 0.768 0.232
M25.58 Pain in joint (Other)
0.000 0.770 0.230
E23.7 Disorder of pituitary gland, unspecified
0.000 0.770 0.230
E13.9 Without complications
0.000 0.782 0.218
M25.71 Osteophyte (Shoulder region)
0.000 0.782 0.218
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.783 0.217
E23.1 Drug-induced hypopituitarism
0.000 0.783 0.217
E22.0 Acromegaly and pituitary gigantism
0.000 0.786 0.214
I22.0 Subsequent myocardial infarction of anterior wall
0.213 0.787 0.000
M25.64 Stiffness of joint, not elsewhere classified (Hand)
0.000 0.788 0.212
M25.9 Joint disorder, unspecified
0.000 0.795 0.205
E03.5 Myxoedema coma
0.001 0.797 0.203
E03.4 Atrophy of thyroid (acquired)
0.001 0.797 0.203
E03.3 Postinfectious hypothyroidism
0.001 0.797 0.203
E03.0 Congenital hypothyroidism with diffuse goitre
0.001 0.797 0.203
M25.77 Osteophyte (Ankle and foot)
0.000 0.797 0.203
M25.72 Osteophyte (Upper arm)
0.000 0.798 0.202
M25.76 Osteophyte (Lower leg)
0.000 0.800 0.200
E03.1 Congenital hypothyroidism without goitre
0.001 0.800 0.199
M25.68 Stiffness of joint, not elsewhere classified (Other)
0.000 0.802 0.197
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.805 0.195
M25.74 Osteophyte (Hand)
0.000 0.810 0.190
E23.2 Diabetes insipidus
0.000 0.813 0.187
M25.60 Stiffness of joint, not elsewhere classified (Multiple sites)
0.000 0.815 0.185
M25.62 Stiffness of joint, not elsewhere classified (Upper arm)
0.000 0.817 0.183
E03.8 Other specified hypothyroidism
0.001 0.817 0.182
M25.73 Osteophyte (Forearm)
0.000 0.818 0.182
M25.0 Haemarthrosis
0.000 0.818 0.182
M25.52 Pain in joint (Upper arm)
0.000 0.818 0.182
M25.96 Joint disorder, unspecified (Lower leg)
0.000 0.818 0.182
M25.63 Stiffness of joint, not elsewhere classified (Forearm)
0.000 0.823 0.177
M25.2 Flail joint
0.000 0.824 0.176
M25.1 Fistula of joint
0.000 0.824 0.176
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.001 0.826 0.173
M25.50 Pain in joint (Multiple sites)
0.000 0.827 0.173
M25.69 Stiffness of joint, not elsewhere classified (Site unspecified)
0.000 0.827 0.173
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.827 0.172
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.827 0.172
E16.4 Abnormal secretion of gastrin
0.000 0.827 0.172
E16.3 Increased secretion of glucagon
0.000 0.827 0.172
E67.8 Other specified hyperalimentation
0.000 0.827 0.172
E67.3 Hypervitaminosis D
0.000 0.827 0.172
E67.2 Megavitamin-B6 syndrome
0.000 0.827 0.172
E67.1 Hypercarotenaemia
0.000 0.827 0.172
E67.0 Hypervitaminosis A
0.000 0.827 0.172
M25.65 Stiffness of joint, not elsewhere classified (Pelvic region and thigh)
0.000 0.829 0.171
M25.70 Osteophyte (Multiple sites)
0.000 0.830 0.170
M25.79 Osteophyte (Site unspecified)
0.000 0.831 0.169
M25.57 Pain in joint (Ankle and foot)
0.000 0.833 0.167
R30.9 Painful micturition, unspecified
0.162 0.837 0.000
M25.91 Joint disorder, unspecified (Shoulder region)
0.000 0.839 0.161
E04 Other non-toxic goitre
0.000 0.840 0.159
E65 Localised adiposity
0.000 0.842 0.158
M25.94 Joint disorder, unspecified (Hand)
0.000 0.844 0.156
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)
0.000 0.845 0.155
I22.9 Subsequent myocardial infarction of unspecified site
0.154 0.845 0.000
M25.78 Osteophyte (Other)
0.000 0.848 0.152
M25.59 Pain in joint (Site unspecified)
0.000 0.850 0.150
E16.1 Other hypoglycaemia
0.000 0.851 0.149
E11.9 Without complications
0.000 0.852 0.148
M25.98 Joint disorder, unspecified (Other)
0.000 0.853 0.147
M25.92 Joint disorder, unspecified (Upper arm)
0.000 0.853 0.147
M25.90 Joint disorder, unspecified (Multiple sites)
0.000 0.853 0.147
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.855 0.145
I21.1 Acute transmural myocardial infarction of inferior wall
0.145 0.855 0.000
M25.99 Joint disorder, unspecified (Site unspecified)
0.000 0.858 0.141
M25.93 Joint disorder, unspecified (Forearm)
0.000 0.859 0.141
M25.95 Joint disorder, unspecified (Pelvic region and thigh)
0.000 0.860 0.139
M25.06 Haemarthrosis (Lower leg)
0.000 0.863 0.137
M25.09 Haemarthrosis (Site unspecified)
0.000 0.869 0.130
M25.08 Haemarthrosis (Other)
0.000 0.869 0.130
M25.07 Haemarthrosis (Ankle and foot)
0.000 0.869 0.130
M25.05 Haemarthrosis (Pelvic region and thigh)
0.000 0.869 0.130
M25.04 Haemarthrosis (Hand)
0.000 0.869 0.130
M25.03 Haemarthrosis (Forearm)
0.000 0.869 0.130
M25.02 Haemarthrosis (Upper arm)
0.000 0.869 0.130
M25.01 Haemarthrosis (Shoulder region)
0.000 0.869 0.130
M25.00 Haemarthrosis (Multiple sites)
0.000 0.869 0.130
E23.6 Other disorders of pituitary gland
0.001 0.870 0.129
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)
0.000 0.870 0.129
M25.19 Fistula of joint (Site unspecified)
0.000 0.874 0.126
M25.18 Fistula of joint (Other)
0.000 0.874 0.126
M25.17 Fistula of joint (Ankle and foot)
0.000 0.874 0.126
M25.16 Fistula of joint (Lower leg)
0.000 0.874 0.126
M25.15 Fistula of joint (Pelvic region and thigh)
0.000 0.874 0.126
M25.14 Fistula of joint (Hand)
0.000 0.874 0.126
M25.13 Fistula of joint (Forearm)
0.000 0.874 0.126
M25.12 Fistula of joint (Upper arm)
0.000 0.874 0.126
M25.11 Fistula of joint (Shoulder region)
0.000 0.874 0.126
M25.10 Fistula of joint (Multiple sites)
0.000 0.874 0.126
M25.29 Flail joint (Site unspecified)
0.000 0.874 0.126
M25.28 Flail joint (Other)
0.000 0.874 0.126
M25.27 Flail joint (Ankle and foot)
0.000 0.874 0.126
M25.26 Flail joint (Lower leg)
0.000 0.874 0.126
M25.25 Flail joint (Pelvic region and thigh)
0.000 0.874 0.126
M25.24 Flail joint (Hand)
0.000 0.874 0.126
M25.23 Flail joint (Forearm)
0.000 0.874 0.126
M25.22 Flail joint (Upper arm)
0.000 0.874 0.126
M25.21 Flail joint (Shoulder region)
0.000 0.874 0.126
M25.20 Flail joint (Multiple sites)
0.000 0.874 0.126
I21.0 Acute transmural myocardial infarction of anterior wall
0.125 0.875 0.000
M25.97 Joint disorder, unspecified (Ankle and foot)
0.000 0.877 0.123
E28.2 Polycystic ovarian syndrome
0.001 0.878 0.121
E16.2 Hypoglycaemia, unspecified
0.000 0.879 0.121
E04.0 Non-toxic diffuse goitre
0.000 0.880 0.120
R39 Other symptoms and signs involving the urinary system
0.118 0.882 0.000
E23.0 Hypopituitarism
0.000 0.884 0.115
E04.8 Other specified non-toxic goitre
0.000 0.885 0.114
H20.9 Iridocyclitis, unspecified
0.111 0.889 0.000
S02.40 Fracture of malar and maxillary bones (closed)
0.000 0.891 0.109
C71 Malignant neoplasm of brain
0.096 0.904 0.000
C71.9 Brain, unspecified
0.094 0.906 0.000
C71.2 Temporal lobe
0.094 0.906 0.000
M25.3 Other instability of joint
0.000 0.908 0.092
C71.0 Cerebrum, except lobes and ventricles
0.092 0.908 0.000
S02.4 Fracture of malar and maxillary bones
0.000 0.909 0.091
R39.2 Extrarenal uraemia
0.085 0.915 0.000
E66 Obesity
0.000 0.916 0.084
M25.8 Other specified joint disorders
0.000 0.918 0.082
C71.3 Parietal lobe
0.082 0.918 0.000
R39.0 Extravasation of urine
0.079 0.921 0.000
S02 Fracture of skull and facial bones
0.000 0.922 0.078
S06 Intracranial injury
0.000 0.927 0.073
R39.8 Other and unspecified symptoms and signs involving the urinary system
0.072 0.928 0.000
S00-S09 Injuries to the head
0.000 0.928 0.072
C71.7 Brain stem
0.069 0.931 0.000
C71.6 Cerebellum
0.069 0.931 0.000
C71.5 Cerebral ventricle
0.069 0.931 0.000
C71.8 Overlapping lesion of brain
0.069 0.931 0.000
S02.6 Fracture of mandible
0.000 0.931 0.068
S06.3 Focal brain injury
0.000 0.932 0.068
K90-K93 Other diseases of the digestive system
0.000 0.933 0.067
M25.31 Other instability of joint (Shoulder region)
0.000 0.934 0.066
M25.39 Other instability of joint (Site unspecified)
0.000 0.934 0.066
M25.38 Other instability of joint (Other)
0.000 0.934 0.066
M25.35 Other instability of joint (Pelvic region and thigh)
0.000 0.934 0.066
M25.32 Other instability of joint (Upper arm)
0.000 0.934 0.066
M25.30 Other instability of joint (Multiple sites)
0.000 0.934 0.066
S02.41 Fracture of malar and maxillary bones (open)
0.000 0.934 0.066
S06.0 Concussion
0.000 0.934 0.065
C71.4 Occipital lobe
0.065 0.935 0.000
S06.30 Focal brain injury (without open intracranial wound)
0.000 0.935 0.065
M25.37 Other instability of joint (Ankle and foot)
0.000 0.936 0.064
S06.2 Diffuse brain injury
0.000 0.937 0.063
S06.5 Traumatic subdural haemorrhage
0.000 0.937 0.063
I21.4 Acute subendocardial myocardial infarction
0.062 0.938 0.000
S02.60 Fracture of mandible (closed)
0.000 0.938 0.062
S05 Injury of eye and orbit
0.000 0.938 0.062
S00 Superficial injury of head
0.000 0.938 0.062
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.939 0.061
E66.1 Drug-induced obesity
0.000 0.940 0.060
S06.00 Concussion (without open intracranial wound)
0.000 0.940 0.060
M25.33 Other instability of joint (Forearm)
0.000 0.940 0.060
N93.8 Other specified abnormal uterine and vaginal bleeding
0.000 0.940 0.060
R32 Unspecified urinary incontinence
0.059 0.941 0.000
S02.9 Fracture of skull and facial bones, part unspecified
0.000 0.941 0.059
S00.1 Contusion of eyelid and periocular area
0.000 0.941 0.059
M25.89 Other specified joint disorders (Site unspecified)
0.000 0.941 0.059
M25.82 Other specified joint disorders (Upper arm)
0.000 0.941 0.059
M25.80 Other specified joint disorders (Multiple sites)
0.000 0.941 0.059
M25.86 Other specified joint disorders (Lower leg)
0.000 0.941 0.059
M25.84 Other specified joint disorders (Hand)
0.000 0.942 0.058
M25.85 Other specified joint disorders (Pelvic region and thigh)
0.000 0.942 0.058
S09 Other and unspecified injuries of head
0.000 0.943 0.057
S06.20 Diffuse brain injury (without open intracranial wound)
0.000 0.943 0.057
S09.8 Other specified injuries of head
0.000 0.944 0.056
M45-M49 Spondylopathies
0.056 0.944 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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