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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs4420638
log Bayes Factor = 199.322
Chromosome 19   position 45,422,946  (GRCh37) Explore rs4420638 on Ensembl!
Variant rs4420638 is listed in the   GWAS Catalog   ⇪
Variant rs4420638 is part of Cluster X0060

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E78.5 Hyperlipidaemia, unspecified
1.000 0.000 0.000
E78.0 Pure hypercholesterolaemia
1.000 0.000 0.000
F00.9 Dementia in Alzheimer's disease, unspecified
1.000 0.000 0.000
F01.9 Vascular dementia, unspecified
1.000 0.000 0.000
G30.9 Alzheimer's disease, unspecified
1.000 0.000 0.000
I20.9 Angina pectoris, unspecified
1.000 0.000 0.000
I25.1 Atherosclerotic heart disease
1.000 0.000 0.000
R41.8 Other and unspecified symptoms and signs involving cognitive functions and awareness
1.000 0.000 0.000
R41.0 Disorientation, unspecified
1.000 0.000 0.000
Z95.1 Presence of aortocoronary bypass graft
1.000 0.000 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
1.000 0.000 0.000
F05 Delirium, not induced by alcohol and other psychoactive substances
1.000 0.000 0.000
F00 Dementia in Alzheimer's disease
1.000 0.000 0.000
F03 Unspecified dementia
1.000 0.000 0.000
G30 Alzheimer's disease
1.000 0.000 0.000
I25 Chronic ischaemic heart disease
1.000 0.000 0.000
I21 Acute myocardial infarction
1.000 0.000 0.000
I20 Angina pectoris
1.000 0.000 0.000
R41 Other symptoms and signs involving cognitive functions and awareness
1.000 0.000 0.000
Z95 Presence of cardiac and vascular implants and grafts
1.000 0.000 0.000
I20-I25 Ischaemic heart diseases
1.000 0.000 0.000
F00-F09 Organic, including symptomatic, mental disorders
1.000 0.000 0.000
Chapter V Mental and behavioural disorders
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
I60-I69 Cerebrovascular diseases
1.000 0.000 0.000
I25.2 Old myocardial infarction
1.000 0.000 0.000
Z95.5 Presence of coronary angioplasty implant and graft
1.000 0.000 0.000
G30-G32 Other degenerative diseases of the nervous system
1.000 0.000 0.000
F01 Vascular dementia
1.000 0.000 0.000
I25.9 Chronic ischaemic heart disease, unspecified
1.000 0.000 0.000
F05.9 Delirium, unspecified
1.000 0.000 0.000
I21.1 Acute transmural myocardial infarction of inferior wall
1.000 0.000 0.000
I20.0 Unstable angina
1.000 0.000 0.000
I21.9 Acute myocardial infarction, unspecified
1.000 0.000 0.000
I25.8 Other forms of chronic ischaemic heart disease
1.000 0.000 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.999 0.001 0.000
Z95.0 Presence of cardiac pacemaker
0.999 0.001 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.999 0.001 0.000
I67 Other cerebrovascular diseases
0.999 0.001 0.000
E70-E90 Metabolic disorders
0.997 0.003 0.000
Chapter VI Diseases of the nervous system
0.997 0.003 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.997 0.003 0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.997 0.003 0.000
Chapter XX External causes of morbidity and mortality
0.996 0.004 0.000
I67.8 Other specified cerebrovascular diseases
0.996 0.004 0.000
I30-I52 Other forms of heart disease
0.996 0.004 0.000
R29 Other symptoms and signs involving the nervous and musculoskeletal systems
0.996 0.004 0.000
R29.6 Tendency to fall, not elsewhere classified
0.995 0.005 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.994 0.006 0.000
I50.1 Left ventricular failure
0.994 0.006 0.000
I50 Heart failure
0.994 0.006 0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.993 0.007 0.000
I21.4 Acute subendocardial myocardial infarction
0.988 0.012 0.000
Z95.8 Presence of other cardiac and vascular implants and grafts
0.987 0.013 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.987 0.013 0.000
I22 Subsequent myocardial infarction
0.987 0.013 0.000
I65.2 Occlusion and stenosis of carotid artery
0.985 0.015 0.000
Y84 Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.985 0.015 0.000
I46 Cardiac arrest
0.985 0.015 0.000
Y84.0 Cardiac catheterisation
0.984 0.016 0.000
F02 Dementia in other diseases classified elsewhere
0.983 0.017 0.000
E78.4 Other hyperlipidaemia
0.980 0.020 0.000
G31.9 Degenerative disease of nervous system, unspecified
0.978 0.022 0.000
I46.0 Cardiac arrest with successful resuscitation
0.977 0.023 0.000
F00.2 Dementia in Alzheimer's disease, atypical or mixed type
0.975 0.025 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.973 0.027 0.000
I21.0 Acute transmural myocardial infarction of anterior wall
0.973 0.027 0.000
F05.0 Delirium not superimposed on dementia, so described
0.971 0.029 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.970 0.030 0.000
E78.2 Mixed hyperlipidaemia
0.968 0.032 0.000
G30.0 Alzheimer's disease with early onset
0.968 0.032 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.965 0.035 0.000
G30.8 Other Alzheimer's disease
0.964 0.036 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.953 0.047 0.000
R47-R49 Symptoms and signs involving speech and voice
0.949 0.051 0.000
I22.1 Subsequent myocardial infarction of inferior wall
0.948 0.052 0.000
E87.0 Hyperosmolality and hypernatraemia
0.948 0.052 0.000
F00.0 Dementia in Alzheimer's disease with early onset
0.946 0.054 0.000
R27 Other lack of coordination
0.943 0.057 0.000
I61 Intracerebral haemorrhage
0.943 0.057 0.000
V40-V49 Car occupant injured in transport accident
0.940 0.060 0.000
F30-F39 Mood [affective] disorders
0.940 0.060 0.000
F05.8 Other delirium
0.934 0.066 0.000
I05-I09 Chronic rheumatic heart diseases
0.933 0.067 0.000
R47 Speech disturbances, not elsewhere classified
0.929 0.071 0.000
G31.8 Other specified degenerative diseases of nervous system
0.928 0.072 0.000
F02.8 Dementia in other specified diseases classified elsewhere
0.927 0.073 0.000
F06 Other mental disorders due to brain damage and dysfunction and to physical disease
0.917 0.083 0.000
R47.0 Dysphasia and aphasia
0.915 0.085 0.000
Y84.2 Radiological procedure and radiotherapy
0.909 0.091 0.000
V49 Car occupant injured in other and unspecified transport accidents
0.904 0.096 0.000
I22.0 Subsequent myocardial infarction of anterior wall
0.903 0.097 0.000
Y43 Primarily systemic agents
0.902 0.098 0.000
G30.1 Alzheimer's disease with late onset
0.899 0.101 0.000
F05.1 Delirium superimposed on dementia
0.898 0.102 0.000
R27.0 Ataxia, unspecified
0.897 0.103 0.000
I25.5 Ischaemic cardiomyopathy
0.897 0.103 0.000
R41.3 Other amnesia
0.896 0.104 0.000
I67.2 Cerebral atherosclerosis
0.891 0.109 0.000
F02.3 Dementia in Parkinson's disease
0.891 0.109 0.000
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.887 0.113 0.000
F25 Schizoaffective disorders
0.886 0.114 0.000
Z95.4 Presence of other heart-valve replacement
0.877 0.123 0.000
G40-G47 Episodic and paroxysmal disorders
0.875 0.125 0.000
Y43.3 Other antineoplastic drugs
0.873 0.127 0.000
E78.8 Other disorders of lipoprotein metabolism
0.872 0.128 0.000
I38 Endocarditis, valve unspecified
0.871 0.129 0.000
F23 Acute and transient psychotic disorders
0.869 0.131 0.000
I08 Multiple valve diseases
0.869 0.131 0.000
F00.1 Dementia in Alzheimer's disease with late onset
0.865 0.135 0.000
Y52 Agents primarily affecting the cardiovascular system
0.865 0.135 0.000
I62 Other nontraumatic intracranial haemorrhage
0.863 0.137 0.000
I69 Sequelae of cerebrovascular disease
0.855 0.145 0.000
V49.9 Car occupant [any] injured in unspecified traffic accident
0.854 0.146 0.000
F06.7 Mild cognitive disorder
0.852 0.148 0.000
I67.1 Cerebral aneurysm, nonruptured
0.851 0.149 0.000
Y48 Anaesthetics and therapeutic gases
0.851 0.149 0.000
G31.0 Circumscribed brain atrophy
0.848 0.152 0.000
R87 Abnormal findings in specimens from female genital organs
0.848 0.152 0.000
Y44 Agents primarily affecting blood constituents
0.847 0.153 0.000
I06 Rheumatic aortic valve diseases
0.846 0.154 0.000
Chapter XXII Codes for special purposes
0.845 0.155 0.000
E85 Amyloidosis
0.834 0.166 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.834 0.166 0.000
F39 Unspecified mood [affective] disorder
0.832 0.168 0.000
I08.8 Other multiple valve diseases
0.828 0.172 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.828 0.172 0.000
R85 Abnormal findings in specimens from digestive organs and abdominal cavity
0.827 0.173 0.000
G70-G73 Diseases of myoneural junction and muscle
0.825 0.175 0.000
F33 Recurrent depressive disorder
0.825 0.175 0.000
Z95.3 Presence of xenogenic heart valve
0.820 0.180 0.000
E87.1 Hypo-osmolality and hyponatraemia
0.817 0.183 0.000
I61.1 Intracerebral haemorrhage in hemisphere, cortical
0.817 0.183 0.000
V01-V09 Pedestrian injured in transport accident
0.813 0.187 0.000
I20.8 Other forms of angina pectoris
0.813 0.187 0.000
E50-E64 Other nutritional deficiencies
0.813 0.187 0.000
I61.4 Intracerebral haemorrhage in cerebellum
0.811 0.189 0.000
I49 Other cardiac arrhythmias
0.810 0.190 0.000
I47 Paroxysmal tachycardia
0.807 0.193 0.000
E87.3 Alkalosis
0.805 0.195 0.000
G44 Other headache syndromes
0.804 0.196 0.000
I49.0 Ventricular fibrillation and flutter
0.803 0.197 0.000
F02.0 Dementia in Pick's disease
0.801 0.199 0.000
Y52.5 Other antihypertensive drugs, not elsewhere classified
0.800 0.200 0.000
G45 Transient cerebral ischaemic attacks and related syndromes
0.797 0.203 0.000
F23.9 Acute and transient psychotic disorder, unspecified
0.795 0.205 0.000
E74 Other disorders of carbohydrate metabolism
0.793 0.207 0.000
I65.0 Occlusion and stenosis of vertebral artery
0.790 0.210 0.000
F29 Unspecified nonorganic psychosis
0.786 0.214 0.000
F34 Persistent mood [affective] disorders
0.785 0.215 0.000
Z95.2 Presence of prosthetic heart valve
0.784 0.216 0.000
F80-F89 Disorders of psychological development
0.784 0.216 0.000
I21.2 Acute transmural myocardial infarction of other sites
0.782 0.218 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.782 0.218 0.000
V20-V29 Motorcycle rider injured in transport accident
0.777 0.223 0.000
V49.4 Driver injured in collision with other and unspecified motor vehicles in traffic accident
0.777 0.223 0.000
I25.3 Aneurysm of heart
0.775 0.225 0.000
E78.1 Pure hyperglyceridaemia
0.774 0.226 0.000
I47.2 Ventricular tachycardia
0.773 0.227 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.770 0.230 0.000
G32 Other degenerative disorders of nervous system in diseases classified elsewhere
0.769 0.231 0.000
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.768 0.232 0.000
X20-X29 Contact with venomous animals and plants
0.767 0.233 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.761 0.239 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.761 0.239 0.000
I61.2 Intracerebral haemorrhage in hemisphere, unspecified
0.759 0.241 0.000
F32 Depressive episode
0.758 0.242 0.000
I61.9 Intracerebral haemorrhage, unspecified
0.757 0.243 0.000
K70-K77 Diseases of liver
0.000 0.243 0.757
G45.9 Transient cerebral ischaemic attack, unspecified
0.757 0.243 0.000
Y84.6 Urinary catheterisation
0.755 0.245 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.753 0.247 0.000
I35 Nonrheumatic aortic valve disorders
0.751 0.249 0.000
K74 Fibrosis and cirrhosis of liver
0.000 0.251 0.749
R46 Symptoms and signs involving appearance and behaviour
0.748 0.252 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.747 0.253 0.000
F22 Persistent delusional disorders
0.746 0.254 0.000
F01.1 Multi-infarct dementia
0.746 0.254 0.000
I25.4 Coronary artery aneurysm
0.745 0.254 0.000
Y84.4 Aspiration of fluid
0.744 0.256 0.000
I22.8 Subsequent myocardial infarction of other sites
0.742 0.258 0.000
K76.0 Fatty (change of) liver, not elsewhere classified
0.000 0.258 0.742
Y10-Y34 Event of undetermined intent
0.741 0.258 0.000
K76 Other diseases of liver
0.000 0.259 0.741
R86 Abnormal findings in specimens from male genital organs
0.739 0.261 0.000
G44.0 Cluster headache syndrome
0.739 0.261 0.000
E87.6 Hypokalaemia
0.739 0.261 0.000
R45 Symptoms and signs involving emotional state
0.739 0.261 0.000
W75-W84 Other accidental threats to breathing
0.739 0.261 0.000
I69.3 Sequelae of cerebral infarction
0.737 0.263 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.737 0.263 0.000
I23 Certain current complications following acute myocardial infarction
0.736 0.264 0.000
R87.6 Abnormal cytological findings
0.736 0.264 0.000
F25.1 Schizoaffective disorder, depressive type
0.735 0.265 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.734 0.266 0.000
I06.1 Rheumatic aortic insufficiency
0.733 0.267 0.000
X00-X09 Exposure to smoke, fire and flames
0.733 0.267 0.000
I69.0 Sequelae of subarachnoid haemorrhage
0.733 0.267 0.000
K72 Hepatic failure, not elsewhere classified
0.000 0.268 0.732
V95-V97 Air and space transport accidents
0.732 0.268 0.000
G70 Myasthenia gravis and other myoneural disorders
0.730 0.270 0.000
I51 Complications and ill-defined descriptions of heart disease
0.730 0.270 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.729 0.271 0.000
I67.9 Cerebrovascular disease, unspecified
0.727 0.273 0.000
R89 Abnormal findings in specimens from other organs, systems and tissues
0.727 0.273 0.000
X50-X57 Overexertion, travel and privation
0.726 0.274 0.000
I65.3 Occlusion and stenosis of multiple and bilateral precerebral arteries
0.724 0.276 0.000
K70 Alcoholic liver disease
0.000 0.276 0.724
K74.3 Primary biliary cirrhosis
0.000 0.276 0.724
I22.9 Subsequent myocardial infarction of unspecified site
0.724 0.276 0.000
E85.4 Organ-limited amyloidosis
0.724 0.276 0.000
R27.8 Other and unspecified lack of coordination
0.723 0.277 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.721 0.279 0.000
Y43.0 Antiallergic and antiemetic drugs
0.720 0.279 0.000
V43 Car occupant injured in collision with car, pick-up truck or van
0.720 0.280 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.720 0.280 0.000
F25.9 Schizoaffective disorder, unspecified
0.720 0.280 0.000
F25.2 Schizoaffective disorder, mixed type
0.719 0.281 0.000
F33.3 Recurrent depressive disorder, current episode severe with psychotic symptoms
0.718 0.282 0.000
Y48.3 Local anaesthetics
0.718 0.282 0.000
E78.3 Hyperchylomicronaemia
0.717 0.283 0.000
I21.X Presumed acute myicardial infaction (unconfirmed)
0.717 0.283 0.000
I25.6 Silent myocardial ischaemia
0.717 0.283 0.000
F09 Unspecified organic or symptomatic mental disorder
0.717 0.283 0.000
F04 Organic amnesic syndrome, not induced by alcohol and other psychoactive substances
0.717 0.283 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
F01.8 Other vascular dementia
0.717 0.283 0.000
F01.3 Mixed cortical and subcortical vascular dementia
0.717 0.283 0.000
F01.2 Subcortical vascular dementia
0.717 0.283 0.000
F01.0 Vascular dementia of acute onset
0.717 0.283 0.000
I62.0 Subdural haemorrhage (acute) (nontraumatic)
0.717 0.283 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.716 0.283 0.000
I67.7 Cerebral arteritis, not elsewhere classified
0.716 0.284 0.000
I67.6 Nonpyogenic thrombosis of intracranial venous system
0.716 0.284 0.000
I67.5 Moyamoya disease
0.716 0.284 0.000
I67.4 Hypertensive encephalopathy
0.716 0.284 0.000
I67.3 Progressive vascular leukoencephalopathy
0.716 0.284 0.000
E84 Cystic fibrosis
0.715 0.285 0.000
E77 Disorders of glycoprotein metabolism
0.715 0.285 0.000
E76 Disorders of glycosaminoglycan metabolism
0.715 0.285 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.715 0.285 0.000
E72 Other disorders of amino-acid metabolism
0.715 0.285 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.715 0.285 0.000
E70 Disorders of aromatic amino-acid metabolism
0.715 0.285 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.715 0.285 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.715 0.285 0.000
G31.1 Senile degeneration of brain, not elsewhere classified
0.714 0.285 0.000
Y35-Y36 Legal intervention and operations of war
0.714 0.286 0.000
X85-X99 Assault
0.714 0.286 0.000
X30-X39 Exposure to forces of nature
0.714 0.286 0.000
W65-W74 Accidental drowning and submersion
0.714 0.286 0.000
V90-V94 Water transport accidents
0.714 0.286 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.714 0.286 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.714 0.286 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.714 0.286 0.000
I33 Acute and subacute endocarditis
0.714 0.286 0.000
I52 Other heart disorders in diseases classified elsewhere
0.714 0.286 0.000
I48 Atrial fibrillation and flutter
0.714 0.286 0.000
I41 Myocarditis in diseases classified elsewhere
0.714 0.286 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.714 0.286 0.000
I32 Pericarditis in diseases classified elsewhere
0.714 0.286 0.000
R29.4 Clicking hip
0.714 0.286 0.000
R29.3 Abnormal posture
0.714 0.286 0.000
R29.2 Abnormal reflex
0.714 0.286 0.000
R29.1 Meningismus
0.714 0.286 0.000
R29.0 Tetany
0.714 0.286 0.000
I06.0 Rheumatic aortic stenosis
0.713 0.287 0.000
Y44.5 Thrombolytic drugs
0.712 0.288 0.000
I65.9 Occlusion and stenosis of unspecified precerebral artery
0.712 0.288 0.000
I65.8 Occlusion and stenosis of other precerebral artery
0.712 0.288 0.000
I09 Other rheumatic heart diseases
0.709 0.291 0.000
Y84.7 Blood-sampling
0.706 0.294 0.000
Y84.5 Insertion of gastric or duodenal sound
0.706 0.294 0.000
Y84.3 Shock therapy
0.706 0.294 0.000
E78.6 Lipoprotein deficiency
0.706 0.294 0.000
I61.3 Intracerebral haemorrhage in brain stem
0.706 0.294 0.000
I46.1 Sudden cardiac death, so described
0.706 0.294 0.000
I68.0 Cerebral amyloid angiopathy
0.705 0.295 0.000
F02.4 Dementia in human immunodeficiency virus [HIV] disease
0.705 0.295 0.000
F02.2 Dementia in Huntington's disease
0.705 0.295 0.000
F02.1 Dementia in Creutzfeldt-Jakob disease
0.705 0.295 0.000
G31.2 Degeneration of nervous system due to alcohol
0.705 0.295 0.000
I00-I02 Acute rheumatic fever
0.704 0.296 0.000
I46.9 Cardiac arrest, unspecified
0.703 0.297 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.702 0.297 0.000
I62.9 Intracranial haemorrhage (nontraumatic), unspecified
0.700 0.300 0.000
E79 Disorders of purine and pyrimidine metabolism
0.700 0.300 0.000
X60-X84 Intentional self-harm
0.699 0.301 0.000
F99-F99 Unspecified mental disorder
0.698 0.302 0.000
K74.5 Biliary cirrhosis, unspecified
0.000 0.302 0.698
F28 Other nonorganic psychotic disorders
0.698 0.302 0.000
F24 Induced delusional disorder
0.698 0.302 0.000
F21 Schizotypal disorder
0.698 0.302 0.000
I69.1 Sequelae of intracerebral haemorrhage
0.697 0.303 0.000
I65.1 Occlusion and stenosis of basilar artery
0.696 0.303 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.695 0.305 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.695 0.305 0.000
I37 Pulmonary valve disorders
0.695 0.305 0.000
Y48.4 Anaesthetic, unspecified
0.695 0.305 0.000
G41 Status epilepticus
0.695 0.305 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.694 0.306 0.000
K72.9 Hepatic failure, unspecified
0.000 0.306 0.694
E80.4 Gilbert's syndrome
0.694 0.306 0.000
F33.0 Recurrent depressive disorder, current episode mild
0.693 0.307 0.000
E87.4 Mixed disorder of acid-base balance
0.692 0.308 0.000
K70.0 Alcoholic fatty liver
0.000 0.308 0.692
R44 Other symptoms and signs involving general sensations and perceptions
0.690 0.310 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.690 0.310 0.000
I51.6 Cardiovascular disease, unspecified
0.687 0.313 0.000
I40 Acute myocarditis
0.686 0.314 0.000
V70-V79 Bus occupant injured in transport accident
0.685 0.314 0.000
R47.8 Other and unspecified speech disturbances
0.685 0.315 0.000
Y58 Bacterial vaccines
0.685 0.315 0.000
R83 Abnormal findings in cerebrospinal fluid
0.684 0.316 0.000
K75 Other inflammatory liver diseases
0.000 0.317 0.683
I30 Acute pericarditis
0.683 0.317 0.000
F20 Schizophrenia
0.682 0.318 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.681 0.319 0.000
I20.1 Angina pectoris with documented spasm
0.681 0.319 0.000
R48 Dyslexia and other symbolic dysfunctions, not elsewhere classified
0.680 0.320 0.000
Y52.0 Cardiac-stimulant glycosides and drugs of similar action
0.680 0.320 0.000
F06.9 Unspecified mental disorder due to brain damage and dysfunction and to physical disease
0.680 0.320 0.000
Y52.2 Other antidysrhythmic drugs, not elsewhere classified
0.679 0.321 0.000
X10-X19 Contact with heat and hot substances
0.679 0.321 0.000
R84 Abnormal findings in specimens from respiratory organs and thorax
0.678 0.322 0.000
R85.8 Other abnormal findings
0.676 0.324 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.676 0.324 0.000
V47 Car occupant injured in collision with fixed or stationary object
0.674 0.326 0.000
V46 Car occupant injured in collision with other nonmotor vehicle
0.674 0.326 0.000
V45 Car occupant injured in collision with railway train or railway vehicle
0.674 0.326 0.000
V42 Car occupant injured in collision with two- or three-wheeled motor vehicle
0.674 0.326 0.000
V41 Car occupant injured in collision with pedal cycle
0.674 0.326 0.000
V40 Car occupant injured in collision with pedestrian or animal
0.674 0.326 0.000
G46 Vascular syndromes of brain in cerebrovascular diseases
0.674 0.326 0.000
F38 Other mood [affective] disorders
0.674 0.326 0.000
I61.8 Other intracerebral haemorrhage
0.672 0.328 0.000
F33.2 Recurrent depressive disorder, current episode severe without psychotic symptoms
0.671 0.329 0.000
I61.6 Intracerebral haemorrhage, multiple localised
0.670 0.329 0.000
Y00-Y09 Assault
0.670 0.330 0.000
I47.0 Reentry ventricular arrhythmia
0.670 0.330 0.000
R43 Disturbances of smell and taste
0.667 0.332 0.000
G70.0 Myasthenia gravis
0.667 0.333 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.666 0.334 0.000
F70-F79 Mental retardation
0.666 0.334 0.000
V98-V99 Other and unspecified transport accidents
0.665 0.334 0.000
I61.0 Intracerebral haemorrhage in hemisphere, subcortical
0.665 0.335 0.000
W20-W49 Exposure to inanimate mechanical forces
0.664 0.336 0.000
K75.8 Other specified inflammatory liver diseases
0.000 0.336 0.664
F60-F69 Disorders of adult personality and behaviour
0.663 0.337 0.000
F32.3 Severe depressive episode with psychotic symptoms
0.662 0.338 0.000
I51.4 Myocarditis, unspecified
0.660 0.340 0.000
F06.8 Other specified mental disorders due to brain damage and dysfunction and to physical disease
0.657 0.343 0.000
F06.6 Organic emotionally labile [asthenic] disorder
0.657 0.343 0.000
F06.5 Organic dissociative disorder
0.657 0.343 0.000
F06.4 Organic anxiety disorder
0.657 0.343 0.000
F06.3 Organic mood [affective] disorders
0.657 0.343 0.000
F06.2 Organic delusional [schizophrenia-like] disorder
0.657 0.343 0.000
F06.1 Organic catatonic disorder
0.657 0.343 0.000
F06.0 Organic hallucinosis
0.657 0.343 0.000
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.657 0.343 0.000
F33.4 Recurrent depressive disorder, currently in remission
0.657 0.343 0.000
F32.1 Moderate depressive episode
0.657 0.343 0.000
K76.6 Portal hypertension
0.000 0.344 0.656
R41.2 Retrograde amnesia
0.656 0.344 0.000
V09 Pedestrian injured in other and unspecified transport accidents
0.656 0.344 0.000
Y44.0 Iron preparations and other anti-hypochromic-anaemia preparations
0.655 0.345 0.000
G44.1 Vascular headache, not elsewhere classified
0.655 0.345 0.000
R85.5 Abnormal microbiological findings
0.654 0.345 0.000
F25.0 Schizoaffective disorder, manic type
0.653 0.347 0.000
Y52.9 Other and unspecified agents primarily affecting the cardiovascular system
0.651 0.348 0.000
R87.9 Unspecified abnormal finding
0.651 0.349 0.000
F34.0 Cyclothymia
0.651 0.349 0.000
R87.7 Abnormal histological findings
0.651 0.349 0.000
G44.2 Tension-type headache
0.650 0.350 0.000
F80 Specific developmental disorders of speech and language
0.650 0.350 0.000
I35.0 Aortic (valve) stenosis
0.650 0.350 0.000
V49.8 Car occupant [any] injured in other specified transport accidents
0.648 0.352 0.000
V49.6 Unspecified car occupant injured in collision with other and unspecified motor vehicles in traffic accident
0.648 0.352 0.000
V49.3 Car occupant [any] injured in unspecified nontraffic accident
0.648 0.352 0.000
V49.2 Unspecified car occupant injured in collision with other and unspecified motor vehicles in nontraffic accident
0.648 0.352 0.000
V49.1 Passenger injured in collision with other and unspecified motor vehicles in nontraffic accident
0.648 0.352 0.000
V49.0 Driver injured in collision with other and unspecified motor vehicles in nontraffic accident
0.648 0.352 0.000
F22.9 Persistent delusional disorder, unspecified
0.647 0.353 0.000
Y43.9 Primarily systemic agent, unspecified
0.646 0.353 0.000
Y43.8 Other primarily systemic agents, not elsewhere classified
0.646 0.353 0.000
Y43.6 Enzymes, not elsewhere classified
0.646 0.353 0.000
Y43.5 Acidifying and alkalising agents
0.646 0.353 0.000
Y43.2 Antineoplastic natural products
0.646 0.353 0.000
E74.3 Other disorders of intestinal carbohydrate absorption
0.646 0.354 0.000
Y59 Other and unspecified vaccines and biological substances
0.646 0.354 0.000
G20-G26 Extrapyramidal and movement disorders
0.646 0.354 0.000
I51.8 Other ill-defined heart diseases
0.645 0.355 0.000
R47.1 Dysarthria and anarthria
0.644 0.356 0.000
R45.1 Restlessness and agitation
0.643 0.357 0.000
E40-E46 Malnutrition
0.642 0.358 0.000
V48 Car occupant injured in noncollision transport accident
0.641 0.359 0.000
E53 Deficiency of other B group vitamins
0.640 0.360 0.000
E61 Deficiency of other nutrient elements
0.640 0.360 0.000
F30 Manic episode
0.640 0.360 0.000
F07 Personality and behavioural disorders due to brain disease, damage and dysfunction
0.637 0.363 0.000
R85.7 Abnormal histological findings
0.637 0.363 0.000
E89.4 Postprocedural ovarian failure
0.637 0.363 0.000
Y52.1 Calcium-channel blockers
0.636 0.364 0.000
F25.8 Other schizoaffective disorders
0.635 0.365 0.000
K72.0 Acute and subacute hepatic failure
0.000 0.365 0.635
U82-U85 Resistance to antimicrobial and antineoplastic drugs
0.632 0.368 0.000
I36 Nonrheumatic tricuspid valve disorders
0.632 0.368 0.000
Y54.8 Agents affecting uric acid metabolism
0.631 0.369 0.000
Y43.1 Antineoplastic antimetabolites
0.631 0.369 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.630 0.369 0.000
I08.9 Multiple valve disease, unspecified
0.630 0.369 0.000
Y44.2 Anticoagulants
0.630 0.370 0.000
V22 Motorcycle rider injured in collision with two- or three-wheeled motor vehicle
0.630 0.370 0.000
I60 Subarachnoid haemorrhage
0.630 0.370 0.000
I49.8 Other specified cardiac arrhythmias
0.630 0.370 0.000
Y44.3 Anticoagulant antagonists, vitamin K and other coagulants
0.628 0.371 0.000
V49.5 Passenger injured in collision with other and unspecified motor vehicles in traffic accident
0.628 0.372 0.000
F45 Somatoform disorders
0.627 0.373 0.000
V44 Car occupant injured in collision with heavy transport vehicle or bus
0.627 0.373 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.627 0.373 0.000
E51 Thiamine deficiency
0.625 0.375 0.000
G45.3 Amaurosis fugax
0.623 0.377 0.000
F23.8 Other acute and transient psychotic disorders
0.623 0.377 0.000
F23.3 Other acute predominantly delusional psychotic disorders
0.623 0.377 0.000
F23.2 Acute schizophrenia-like psychotic disorder
0.623 0.377 0.000
F23.1 Acute polymorphic psychotic disorder with symptoms of schizophrenia
0.623 0.377 0.000
F23.0 Acute polymorphic psychotic disorder without symptoms of schizophrenia
0.623 0.377 0.000
R45.6 Physical violence
0.623 0.377 0.000
E80.6 Other disorders of bilirubin metabolism
0.622 0.378 0.000
Y52.8 Antivaricose drugs, including sclerosing agents
0.620 0.380 0.000
Y52.7 Peripheral vasodilators
0.620 0.380 0.000
I62.1 Nontraumatic extradural haemorrhage
0.619 0.381 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.618 0.382 0.000
X58 Exposure to other specified factors
0.617 0.383 0.000
E80.2 Other porphyria
0.614 0.385 0.000
I69.8 Sequelae of other and unspecified cerebrovascular diseases
0.614 0.386 0.000
E85.3 Secondary systemic amyloidosis
0.613 0.386 0.000
E56 Other vitamin deficiencies
0.613 0.387 0.000
V01 Pedestrian injured in collision with pedal cycle
0.611 0.389 0.000
X67 Intentional self-poisoning by and exposure to other gases and vapours
0.610 0.390 0.000
I50.9 Heart failure, unspecified
0.610 0.390 0.000
Y48.5 Therapeutic gases
0.610 0.390 0.000
Y48.2 Other and unspecified general anaesthetics
0.610 0.390 0.000
Y48.1 Parenteral anaesthetics
0.610 0.390 0.000
Y48.0 Inhaled anaesthetics
0.610 0.390 0.000
F84 Pervasive developmental disorders
0.610 0.390 0.000
V80-V89 Other land transport accidents
0.609 0.391 0.000
R41.1 Anterograde amnesia
0.608 0.391 0.000
W94 Exposure to high and low air pressure and changes in air pressure
0.608 0.392 0.000
Y54.4 Loop [high-ceiling] diuretics
0.608 0.392 0.000
R87.8 Other abnormal findings
0.608 0.392 0.000
R87.5 Abnormal microbiological findings
0.608 0.392 0.000
R87.4 Abnormal immunological findings
0.608 0.392 0.000
R87.3 Abnormal level of substances chiefly nonmedicinal as to source
0.608 0.392 0.000
R87.2 Abnormal level of other drugs, medicaments and biological substances
0.608 0.392 0.000
R87.1 Abnormal level of hormones
0.608 0.392 0.000
R87.0 Abnormal level of enzymes
0.608 0.392 0.000
V02 Pedestrian injured in collision with two- or three-wheeled motor vehicle
0.608 0.392 0.000
Y44.9 Other and unspecified agents affecting blood constituents
0.607 0.393 0.000
Y44.7 Plasma substitutes
0.607 0.393 0.000
Y44.6 Natural blood and blood products
0.607 0.393 0.000
Y44.4 Antithrombotic drugs [platelet-aggregation inhibitors]
0.607 0.393 0.000
Y44.1 Vitamin B12, folic acid and other anti-megaloblastic-anaemia preparations
0.607 0.393 0.000
I06.9 Rheumatic aortic valve disease, unspecified
0.606 0.394 0.000
I06.8 Other rheumatic aortic valve diseases
0.606 0.394 0.000
I06.2 Rheumatic aortic stenosis with insufficiency
0.606 0.394 0.000
Y49.0 Tricyclic and tetracyclic antidepressants
0.606 0.394 0.000
Y54.1 Mineralocorticoid antagonists [aldosterone antagonists]
0.605 0.395 0.000
G32.8 Other specified degenerative disorders of nervous system in diseases classified elsewhere
0.603 0.396 0.000
X23 Contact with hornets, wasps and bees
0.603 0.397 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.603 0.397 0.000
E58 Dietary calcium deficiency
0.603 0.397 0.000
F32.2 Severe depressive episode without psychotic symptoms
0.602 0.398 0.000
Y52.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.601 0.399 0.000
F34.1 Dysthymia
0.600 0.400 0.000
F32.8 Other depressive episodes
0.599 0.401 0.000
E85.8 Other amyloidosis
0.598 0.402 0.000
E85.2 Heredofamilial amyloidosis, unspecified
0.598 0.402 0.000
E85.1 Neuropathic heredofamilial amyloidosis
0.598 0.402 0.000
E85.0 Nonneuropathic heredofamilial amyloidosis
0.598 0.402 0.000
I08.0 Disorders of both mitral and aortic valves
0.598 0.402 0.000
E80.7 Disorder of bilirubin metabolism, unspecified
0.598 0.402 0.000
E80.5 Crigler-Najjar syndrome
0.598 0.402 0.000
E80.3 Defects of catalase and peroxydase
0.598 0.402 0.000
E80.1 Porphyria cutanea tarda
0.598 0.402 0.000
E80.0 Hereditary erythropoietic porphyria
0.598 0.402 0.000
V24 Motorcycle rider injured in collision with heavy transport vehicle or bus
0.598 0.402 0.000
I67.0 Dissection of cerebral arteries, nonruptured
0.597 0.403 0.000
R44.1 Visual hallucinations
0.597 0.403 0.000
R46.2 Strange and inexplicable behaviour
0.596 0.404 0.000
I68.8 Other cerebrovascular disorders in diseases classified elsewhere
0.594 0.406 0.000
I68.2 Cerebral arteritis in other diseases classified elsewhere
0.594 0.406 0.000
I68.1 Cerebral arteritis in infectious and parasitic diseases classified elsewhere
0.594 0.406 0.000
R85.9 Unspecified abnormal finding
0.593 0.407 0.000
R85.6 Abnormal cytological findings
0.593 0.407 0.000
R85.4 Abnormal immunological findings
0.593 0.407 0.000
R85.3 Abnormal level of substances chiefly nonmedicinal as to source
0.593 0.407 0.000
R85.2 Abnormal level of other drugs, medicaments and biological substances
0.593 0.407 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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