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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs62237594
log Bayes Factor = 13.6107
Chromosome 21   position 41,465,664  (GRCh37) Explore rs62237594 on Ensembl!
Variant rs62237594 is part of Cluster X0124

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
I30-I52 Other forms of heart disease
1.000 0.000 0.000
Chapter X Diseases of the respiratory system
0.999 0.001 0.000
Chapter V Mental and behavioural disorders
0.997 0.003 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.997 0.003 0.000
Chapter II Neoplasms
0.993 0.007 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.992 0.008 0.000
J40-J47 Chronic lower respiratory diseases
0.988 0.012 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.987 0.013 0.000
I20-I25 Ischaemic heart diseases
0.984 0.016 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.976 0.024 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.974 0.026 0.000
Chapter XIV Diseases of the genitourinary system
0.972 0.028 0.000
J09-J18 Influenza and pneumonia
0.970 0.030 0.000
F17 Mental and behavioural disorders due to use of tobacco
0.965 0.035 0.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes
0.964 0.036 0.000
I21 Acute myocardial infarction
0.963 0.037 0.000
Chapter XI Diseases of the digestive system
0.961 0.039 0.000
M70-M79 Other soft tissue disorders
0.960 0.040 0.000
I34 Nonrheumatic mitral valve disorders
0.959 0.041 0.000
I51 Complications and ill-defined descriptions of heart disease
0.956 0.044 0.000
F17.1 Harmful use
0.952 0.048 0.000
J40 Bronchitis, not specified as acute or chronic
0.951 0.049 0.000
N81 Female genital prolapse
0.948 0.052 0.000
N80-N98 Noninflammatory disorders of female genital tract
0.946 0.054 0.000
J20-J22 Other acute lower respiratory infections
0.939 0.061 0.000
N81.1 Cystocele
0.938 0.062 0.000
J18 Pneumonia, organism unspecified
0.935 0.065 0.000
I05-I09 Chronic rheumatic heart diseases
0.934 0.066 0.000
I45 Other conduction disorders
0.934 0.066 0.000
Chapter XX External causes of morbidity and mortality
0.933 0.067 0.000
Chapter XXI Factors influencing health status and contact with health services
0.932 0.068 0.000
K50-K52 Noninfective enteritis and colitis
0.932 0.068 0.000
S80-S89 Injuries to the knee and lower leg
0.929 0.071 0.000
I46 Cardiac arrest
0.927 0.072 0.000
K00-K14 Diseases of oral cavity, salivary glands and jaws
0.925 0.075 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.925 0.075 0.000
K52 Other non-infective gastro-enteritis and colitis
0.923 0.077 0.000
K52.9 Non-infective gastro-enteritis and colitis, unspecified
0.918 0.082 0.000
I21.0 Acute transmural myocardial infarction of anterior wall
0.916 0.084 0.000
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status
0.915 0.085 0.000
Z95 Presence of cardiac and vascular implants and grafts
0.911 0.089 0.000
J18.1 Lobar pneumonia, unspecified
0.909 0.091 0.000
M20-M25 Other joint disorders
0.907 0.093 0.000
I42 Cardiomyopathy
0.907 0.093 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.906 0.094 0.000
M05-M14 Inflammatory polyarthropathies
0.905 0.095 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.905 0.095 0.000
Z30-Z39 Persons encountering health services in circumstances related to reproduction
0.902 0.098 0.000
Z82 Family history of certain disabilities and chronic diseases leading to disablement
0.899 0.101 0.000
N17-N19 Renal failure
0.899 0.101 0.000
J22 Unspecified acute lower respiratory infection
0.896 0.104 0.000
I08 Multiple valve diseases
0.896 0.104 0.000
F10 Mental and behavioural disorders due to use of alcohol
0.894 0.106 0.000
I21.9 Acute myocardial infarction, unspecified
0.893 0.107 0.000
C15-C26 Malignant neoplasms of digestive organs
0.893 0.107 0.000
I34.0 Mitral (valve) insufficiency
0.890 0.110 0.000
C77.3 Axillary and upper limb lymph nodes
0.888 0.112 0.000
I46.0 Cardiac arrest with successful resuscitation
0.888 0.112 0.000
Z95.5 Presence of coronary angioplasty implant and graft
0.885 0.115 0.000
I51.8 Other ill-defined heart diseases
0.884 0.116 0.000
F30-F39 Mood [affective] disorders
0.884 0.116 0.000
Z30 Contraceptive management
0.881 0.119 0.000
Chapter I Certain infectious and parasitic diseases
0.881 0.119 0.000
M80-M85 Disorders of bone density and structure
0.878 0.122 0.000
J45 Asthma
0.875 0.125 0.000
N94 Pain and other conditions associated with female genital organs and menstrual cycle
0.870 0.130 0.000
I31 Other diseases of pericardium
0.865 0.135 0.000
Chapter VII Diseases of the eye and adnexa
0.864 0.136 0.000
I50 Heart failure
0.862 0.138 0.000
N81.4 Uterovaginal prolapse, unspecified
0.861 0.139 0.000
N89 Other noninflammatory disorders of vagina
0.856 0.144 0.000
I45.1 Other and unspecified right bundle-branch block
0.846 0.153 0.000
K14 Diseases of tongue
0.843 0.157 0.000
Z30.2 Sterilisation
0.843 0.157 0.000
S10-S19 Injuries to the neck
0.837 0.163 0.000
C80 Malignant neoplasm without specification of site
0.832 0.168 0.000
I42.9 Cardiomyopathy, unspecified
0.829 0.171 0.000
T39.0 Salicylates
0.826 0.174 0.000
D00-D09 In situ neoplasms
0.826 0.174 0.000
F60-F69 Disorders of adult personality and behaviour
0.825 0.175 0.000
M72 Fibroblastic disorders
0.825 0.175 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.825 0.175 0.000
I35 Nonrheumatic aortic valve disorders
0.825 0.175 0.000
Z82.4 Family history of ischaemic heart disease and other diseases of the circulatory system
0.824 0.176 0.000
M77 Other enthesopathies
0.823 0.177 0.000
M24 Other specific joint derangements
0.820 0.180 0.000
Z95.2 Presence of prosthetic heart valve
0.819 0.181 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.818 0.182 0.000
M81 Osteoporosis without pathological fracture
0.816 0.184 0.000
Z92 Personal history of medical treatment
0.814 0.186 0.000
D45 Polycythaemia vera
0.812 0.188 0.000
N81.2 Incomplete uterovaginal prolapse
0.812 0.188 0.000
J47 Bronchiectasis
0.811 0.189 0.000
S50-S59 Injuries to the elbow and forearm
0.810 0.190 0.000
K35-K38 Diseases of appendix
0.809 0.191 0.000
F10.1 Harmful use
0.809 0.191 0.000
K20-K31 Diseases of oesophagus, stomach and duodenum
0.807 0.193 0.000
I34.1 Mitral (valve) prolapse
0.807 0.193 0.000
C77.0 Lymph nodes of head, face and neck
0.807 0.193 0.000
C77.4 Inguinal and lower limb lymph nodes
0.807 0.193 0.000
J42 Unspecified chronic bronchitis
0.807 0.193 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.807 0.193 0.000
J00-J06 Acute upper respiratory infections
0.806 0.194 0.000
Z35 Supervision of high-risk pregnancy
0.806 0.194 0.000
F32 Depressive episode
0.804 0.196 0.000
A00-A09 Intestinal infectious diseases
0.804 0.196 0.000
V20-V29 Motorcycle rider injured in transport accident
0.804 0.196 0.000
M71 Other bursopathies
0.801 0.199 0.000
C21 Malignant neoplasm of anus and anal canal
0.800 0.200 0.000
S89 Other and unspecified injuries of lower leg
0.798 0.202 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.797 0.203 0.000
I20 Angina pectoris
0.797 0.203 0.000
I24 Other acute ischaemic heart diseases
0.795 0.205 0.000
K11 Diseases of salivary glands
0.795 0.205 0.000
K26 Duodenal ulcer
0.795 0.205 0.000
M06 Other rheumatoid arthritis
0.794 0.206 0.000
J60-J70 Lung diseases due to external agents
0.793 0.207 0.000
Z94 Transplanted organ and tissue status
0.793 0.207 0.000
Chapter XXII Codes for special purposes
0.792 0.208 0.000
C77.1 Intrathoracic lymph nodes
0.791 0.209 0.000
Z90 Acquired absence of organs, not elsewhere classified
0.790 0.210 0.000
N94.8 Other specified conditions associated with female genital organs and menstrual cycle
0.789 0.211 0.000
S81 Open wound of lower leg
0.789 0.211 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.788 0.212 0.000
I51.7 Cardiomegaly
0.788 0.212 0.000
T39.1 4-Aminophenol derivatives
0.786 0.214 0.000
I51.0 Cardiac septal defect, acquired
0.783 0.217 0.000
I08.1 Disorders of both mitral and tricuspid valves
0.783 0.217 0.000
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.781 0.219 0.000
Z82.5 Family history of asthma and other chronic lower respiratory diseases
0.780 0.220 0.000
K04 Diseases of pulp and periapical tissues
0.779 0.221 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.777 0.223 0.000
Z95.4 Presence of other heart-valve replacement
0.777 0.223 0.000
M25 Other joint disorders, not elsewhere classified
0.776 0.224 0.000
C77.9 Lymph node, unspecified
0.775 0.225 0.000
J14 Pneumonia due to Haemophilus influenzae
0.774 0.226 0.000
N81.5 Vaginal enterocele
0.774 0.226 0.000
C79 Secondary malignant neoplasm of other sites
0.774 0.226 0.000
C15 Malignant neoplasm of oesophagus
0.773 0.227 0.000
N00-N08 Glomerular diseases
0.772 0.228 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.771 0.229 0.000
N18 Chronic renal failure
0.770 0.230 0.000
I30 Acute pericarditis
0.770 0.230 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.770 0.230 0.000
I45.8 Other specified conduction disorders
0.769 0.231 0.000
N17 Acute renal failure
0.769 0.231 0.000
M86-M90 Other osteopathies
0.768 0.232 0.000
C43-C44 Melanoma and other malignant neoplasms of skin
0.768 0.232 0.000
J10 Influenza due to identified influenza virus
0.767 0.233 0.000
M05 Seropositive rheumatoid arthritis
0.767 0.233 0.000
M81.9 Osteoporosis, unspecified
0.766 0.234 0.000
Z82.7 Family history of congenital malformations, deformations and chromosomal abnormalities
0.766 0.234 0.000
M15-M19 Arthrosis
0.766 0.234 0.000
N10-N16 Renal tubulo-interstitial diseases
0.765 0.235 0.000
C16 Malignant neoplasm of stomach
0.765 0.235 0.000
S20-S29 Injuries to the thorax
0.765 0.235 0.000
K26.9 Unspecified as acute or chronic, without haemorrhage or perforation
0.763 0.237 0.000
S82 Fracture of lower leg, including ankle
0.763 0.237 0.000
C50-C50 Malignant neoplasm of breast
0.760 0.240 0.000
K90-K93 Other diseases of the digestive system
0.760 0.240 0.000
Z89 Acquired absence of limb
0.759 0.241 0.000
J46 Status asthmaticus
0.759 0.241 0.000
K14.9 Disease of tongue, unspecified
0.759 0.241 0.000
Z95.8 Presence of other cardiac and vascular implants and grafts
0.757 0.243 0.000
M60-M63 Disorders of muscles
0.757 0.243 0.000
M34 Systemic sclerosis
0.756 0.244 0.000
M75 Shoulder lesions
0.756 0.244 0.000
M65-M68 Disorders of synovium and tendon
0.756 0.244 0.000
I34.9 Nonrheumatic mitral valve disorder, unspecified
0.755 0.244 0.000
I10-I15 Hypertensive diseases
0.755 0.245 0.000
F32.9 Depressive episode, unspecified
0.755 0.245 0.000
C60-C63 Malignant neoplasms of male genital organs
0.755 0.245 0.000
K08 Other disorders of teeth and supporting structures
0.753 0.247 0.000
T79-T79 Certain early complications of trauma
0.752 0.248 0.000
K22 Other diseases of oesophagus
0.751 0.249 0.000
N18.3 Chronic kidney disease, stage 3
0.751 0.249 0.000
I25 Chronic ischaemic heart disease
0.750 0.250 0.000
K12 Stomatitis and related lesions
0.749 0.251 0.000
F80-F89 Disorders of psychological development
0.749 0.251 0.000
N99-N99 Other disorders of the genitourinary system
0.749 0.251 0.000
N94.6 Dysmenorrhoea, unspecified
0.748 0.252 0.000
Y95 Nosocomial condition
0.747 0.253 0.000
X60-X84 Intentional self-harm
0.747 0.253 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.747 0.253 0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.746 0.254 0.000
N81.3 Complete uterovaginal prolapse
0.746 0.254 0.000
N89.8 Other specified noninflammatory disorders of vagina
0.745 0.255 0.000
C77.8 Lymph nodes of multiple regions
0.745 0.255 0.000
I45.9 Conduction disorder, unspecified
0.745 0.255 0.000
N97 Female infertility
0.745 0.255 0.000
Z90.7 Acquired absence of genital organ(s)
0.743 0.257 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.742 0.258 0.000
C77.2 Intra-abdominal lymph nodes
0.742 0.258 0.000
I21.1 Acute transmural myocardial infarction of inferior wall
0.740 0.260 0.000
C51-C58 Malignant neoplasms of female genital organs
0.740 0.260 0.000
J45.0 Predominantly allergic asthma
0.740 0.260 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.738 0.262 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.737 0.263 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.736 0.264 0.000
H30-H36 Disorders of choroid and retina
0.735 0.265 0.000
I50.9 Heart failure, unspecified
0.735 0.265 0.000
Z93 Artificial opening status
0.733 0.267 0.000
I31.9 Disease of pericardium, unspecified
0.733 0.267 0.000
I08.8 Other multiple valve diseases
0.732 0.268 0.000
Z92.2 Personal history of long-term (current) use of other medicaments
0.732 0.268 0.000
Z82.0 Family history of epilepsy and other diseases of the nervous system
0.731 0.269 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.730 0.270 0.000
M00-M03 Infectious arthropathies
0.730 0.270 0.000
Z92.6 Personal history of chemotherapy for neoplastic disease
0.730 0.270 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.730 0.270 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.728 0.272 0.000
Z95.0 Presence of cardiac pacemaker
0.726 0.274 0.000
N81.8 Other female genital prolapse
0.725 0.275 0.000
J45.9 Asthma, unspecified
0.725 0.275 0.000
I45.2 Bifascicular block
0.725 0.275 0.000
M24.1 Other articular cartilage disorders
0.725 0.275 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.723 0.277 0.000
I20.8 Other forms of angina pectoris
0.723 0.277 0.000
H53-H54 Visual disturbances and blindness
0.723 0.277 0.000
M40-M43 Deforming dorsopathies
0.720 0.279 0.000
Q80-Q89 Other congenital malformations
0.720 0.279 0.000
N81.6 Rectocele
0.720 0.280 0.000
Z95.3 Presence of xenogenic heart valve
0.719 0.281 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.719 0.281 0.000
K52.3 Indeterminate colitis
0.718 0.282 0.000
M72.0 Palmar fascial fibromatosis [Dupuytren]
0.718 0.282 0.000
W50-W64 Exposure to animate mechanical forces
0.718 0.282 0.000
Z30.8 Other contraceptive management
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
I52 Other heart disorders in diseases classified elsewhere
0.717 0.283 0.000
I48 Atrial fibrillation and flutter
0.717 0.283 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.717 0.283 0.000
I41 Myocarditis in diseases classified elsewhere
0.717 0.283 0.000
I40 Acute myocarditis
0.717 0.283 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.717 0.283 0.000
I37 Pulmonary valve disorders
0.717 0.283 0.000
I36 Nonrheumatic tricuspid valve disorders
0.717 0.283 0.000
I32 Pericarditis in diseases classified elsewhere
0.717 0.283 0.000
I33 Acute and subacute endocarditis
0.716 0.284 0.000
S00-S09 Injuries to the head
0.715 0.285 0.000
M06.9 Rheumatoid arthritis, unspecified
0.715 0.285 0.000
F99-F99 Unspecified mental disorder
0.715 0.285 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.715 0.285 0.000
F70-F79 Mental retardation
0.715 0.285 0.000
Z30.5 Surveillance of (intra-uterine) contraceptive device
0.715 0.285 0.000
M77.4 Metatarsalgia
0.715 0.285 0.000
J11 Influenza, virus not identified
0.714 0.286 0.000
Q60-Q64 Congenital malformations of the urinary system
0.714 0.286 0.000
I35.1 Aortic (valve) insufficiency
0.714 0.286 0.000
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.712 0.287 0.000
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.712 0.288 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.712 0.288 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.712 0.288 0.000
T33-T35 Frostbite
0.712 0.288 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.712 0.288 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.712 0.288 0.000
T00-T07 Injuries involving multiple body regions
0.712 0.288 0.000
V23 Motorcycle rider injured in collision with car, pick-up truck or van
0.711 0.289 0.000
V80-V89 Other land transport accidents
0.711 0.289 0.000
H55-H59 Other disorders of eye and adnexa
0.711 0.289 0.000
D46 Myelodysplastic syndromes
0.710 0.290 0.000
C21.0 Anus, unspecified
0.710 0.290 0.000
J95-J99 Other diseases of the respiratory system
0.709 0.290 0.000
K05 Gingivitis and periodontal diseases
0.709 0.291 0.000
J41 Simple and mucopurulent chronic bronchitis
0.709 0.291 0.000
F10.4 Withdrawal state with delirium
0.709 0.291 0.000
F19 Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances
0.708 0.292 0.000
F18 Mental and behavioural disorders due to use of volatile solvents
0.708 0.292 0.000
F16 Mental and behavioural disorders due to use of hallucinogens
0.708 0.292 0.000
F15 Mental and behavioural disorders due to use of other stimulants, including caffeine
0.708 0.292 0.000
F14 Mental and behavioural disorders due to use of cocaine
0.708 0.292 0.000
F13 Mental and behavioural disorders due to use of sedatives or hypnotics
0.708 0.292 0.000
F12 Mental and behavioural disorders due to use of cannabinoids
0.708 0.292 0.000
F11 Mental and behavioural disorders due to use of opioids
0.708 0.292 0.000
N40-N51 Diseases of male genital organs
0.707 0.293 0.000
S90-S99 Injuries to the ankle and foot
0.707 0.293 0.000
V10-V19 Pedal cyclist injured in transport accident
0.706 0.294 0.000
M19 Other arthrosis
0.706 0.294 0.000
Chapter VIII Diseases of the ear and mastoid process
0.706 0.294 0.000
I23 Certain current complications following acute myocardial infarction
0.705 0.295 0.000
Chapter VI Diseases of the nervous system
0.705 0.295 0.000
S89.9 Unspecified injury of lower leg
0.704 0.296 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.704 0.296 0.000
S12 Fracture of neck
0.703 0.297 0.000
F60 Specific personality disorders
0.702 0.298 0.000
M91-M94 Chondropathies
0.702 0.298 0.000
K09 Cysts of oral region, not elsewhere classified
0.702 0.298 0.000
K37 Unspecified appendicitis
0.701 0.299 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.701 0.299 0.000
C76 Malignant neoplasm of other and ill-defined sites
0.700 0.300 0.000
A80-A89 Viral infections of the central nervous system
0.699 0.301 0.000
M31 Other necrotising vasculopathies
0.699 0.301 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.698 0.301 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.698 0.301 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.698 0.301 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.698 0.301 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.698 0.301 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.698 0.301 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.698 0.301 0.000
T36 Poisoning by systemic antibiotics
0.698 0.301 0.000
K06 Other disorders of gingiva and edentulous alveolar ridge
0.698 0.302 0.000
N86 Erosion and ectropion of cervix uteri
0.698 0.302 0.000
Z34 Supervision of normal pregnancy
0.697 0.303 0.000
F10.0 Acute intoxication
0.697 0.303 0.000
Z82.6 Family history of arthritis and other diseases of the musculoskeletal system and connective tissue
0.697 0.303 0.000
N19 Unspecified renal failure
0.696 0.304 0.000
A09 Diarrhoea and gastro-enteritis of presumed infectious origin
0.696 0.304 0.000
C80.9 Malignant neoplasm, unspecified
0.696 0.304 0.000
I42.8 Other cardiomyopathies
0.695 0.304 0.000
J17 Pneumonia in diseases classified elsewhere
0.695 0.305 0.000
J16 Pneumonia due to other infectious organisms, not elsewhere classified
0.695 0.305 0.000
J15 Bacterial pneumonia, not elsewhere classified
0.695 0.305 0.000
J12 Viral pneumonia, not elsewhere classified
0.695 0.305 0.000
J09 Influenza due to certain identified influenza virus
0.695 0.305 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.695 0.305 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.695 0.305 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.693 0.307 0.000
Z35.8 Supervision of other high-risk pregnancies
0.692 0.308 0.000
F17.9 Unspecified mental and behavioural disorder
0.692 0.308 0.000
F17.8 Other mental and behavioural disorders
0.692 0.308 0.000
F17.7 Residual and late-onset psychotic disorder
0.692 0.308 0.000
F17.6 Amnesic syndrome
0.692 0.308 0.000
F17.5 Psychotic disorder
0.692 0.308 0.000
F17.4 Withdrawal state with delirium
0.692 0.308 0.000
F17.3 Withdrawal state
0.692 0.308 0.000
F17.0 Acute intoxication
0.692 0.308 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.692 0.308 0.000
B50-B64 Protozoal diseases
0.692 0.308 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.691 0.309 0.000
I73 Other peripheral vascular diseases
0.691 0.309 0.000
I21.X Presumed acute myicardial infaction (unconfirmed)
0.690 0.310 0.000
I21.3 Acute transmural myocardial infarction of unspecified site
0.690 0.310 0.000
D03 Melanoma in situ
0.690 0.310 0.000
K14.8 Other diseases of tongue
0.689 0.311 0.000
M25.7 Osteophyte
0.689 0.311 0.000
A30-A49 Other bacterial diseases
0.689 0.311 0.000
M76 Enthesopathies of lower limb, excluding foot
0.688 0.312 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.688 0.312 0.000
I34.8 Other nonrheumatic mitral valve disorders
0.688 0.312 0.000
I34.2 Nonrheumatic mitral (valve) stenosis
0.688 0.312 0.000
N87 Dysplasia of cervix uteri
0.687 0.313 0.000
D41 Neoplasm of uncertain or unknown behaviour of urinary organs
0.687 0.313 0.000
F33 Recurrent depressive disorder
0.686 0.314 0.000
I51.6 Cardiovascular disease, unspecified
0.686 0.314 0.000
I51.5 Myocardial degeneration
0.686 0.314 0.000
I51.4 Myocarditis, unspecified
0.686 0.314 0.000
I51.3 Intracardiac thrombosis, not elsewhere classified
0.686 0.314 0.000
I51.2 Rupture of papillary muscle, not elsewhere classified
0.686 0.314 0.000
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.686 0.314 0.000
I31.3 Pericardial effusion (noninflammatory)
0.685 0.314 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.685 0.315 0.000
K01 Embedded and impacted teeth
0.685 0.315 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.685 0.315 0.000
J18.9 Pneumonia, unspecified
0.685 0.315 0.000
M35 Other systemic involvement of connective tissue
0.684 0.315 0.000
Z94.0 Kidney transplant status
0.683 0.317 0.000
Z99 Dependence on enabling machines and devices, not elsewhere classified
0.682 0.318 0.000
I08.0 Disorders of both mitral and aortic valves
0.682 0.318 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.681 0.319 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.681 0.319 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.681 0.319 0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee
0.680 0.320 0.000
N81.0 Female urethrocele
0.679 0.321 0.000
D09 Carcinoma in situ of other and unspecified sites
0.679 0.321 0.000
K26.5 Chronic or unspecified with perforation
0.679 0.321 0.000
Q50-Q56 Congenital malformations of genital organs
0.678 0.321 0.000
M81.90 Osteoporosis, unspecified (Multiple sites)
0.678 0.322 0.000
N98 Complications associated with artificial fertilisation
0.678 0.322 0.000
N91 Absent, scanty and rare menstruation
0.678 0.322 0.000
N82 Fistulae involving female genital tract
0.678 0.322 0.000
N96 Habitual aborter
0.678 0.322 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.677 0.322 0.000
N89.6 Tight hymenal ring
0.676 0.324 0.000
K22.1 Ulcer of oesophagus
0.676 0.324 0.000
S81.0 Open wound of knee
0.676 0.324 0.000
T43.2 Other and unspecified antidepressants
0.676 0.324 0.000
I42.0 Dilated cardiomyopathy
0.675 0.324 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.675 0.325 0.000
N17.9 Acute renal failure, unspecified
0.675 0.325 0.000
J21 Acute bronchiolitis
0.673 0.326 0.000
J20 Acute bronchitis
0.673 0.326 0.000
K00 Disorders of tooth development and eruption
0.673 0.327 0.000
N94.3 Premenstrual tension syndrome
0.673 0.327 0.000
M13 Other arthritis
0.673 0.327 0.000
A08 Viral and other specified intestinal infections
0.673 0.327 0.000
N88 Other noninflammatory disorders of cervix uteri
0.670 0.329 0.000
J18.8 Other pneumonia, organism unspecified
0.670 0.330 0.000
J18.2 Hypostatic pneumonia, unspecified
0.670 0.330 0.000
I09 Other rheumatic heart diseases
0.670 0.330 0.000
I06 Rheumatic aortic valve diseases
0.670 0.330 0.000
K22.7 Barrett's oesophagus
0.670 0.330 0.000
K55-K64 Other diseases of intestines
0.669 0.331 0.000
I45.5 Other specified heart block
0.669 0.331 0.000
I45.4 Nonspecific intraventricular block
0.669 0.331 0.000
I45.3 Trifascicular block
0.669 0.331 0.000
I45.0 Right fascicular block
0.669 0.331 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.669 0.331 0.000
Y35-Y36 Legal intervention and operations of war
0.669 0.331 0.000
Y10-Y34 Event of undetermined intent
0.669 0.331 0.000
Y00-Y09 Assault
0.669 0.331 0.000
X85-X99 Assault
0.669 0.331 0.000
X50-X57 Overexertion, travel and privation
0.669 0.331 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.669 0.331 0.000
X30-X39 Exposure to forces of nature
0.669 0.331 0.000
X20-X29 Contact with venomous animals and plants
0.669 0.331 0.000
X10-X19 Contact with heat and hot substances
0.669 0.331 0.000
X00-X09 Exposure to smoke, fire and flames
0.669 0.331 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.669 0.331 0.000
W75-W84 Other accidental threats to breathing
0.669 0.331 0.000
W65-W74 Accidental drowning and submersion
0.669 0.331 0.000
V98-V99 Other and unspecified transport accidents
0.669 0.331 0.000
V95-V97 Air and space transport accidents
0.669 0.331 0.000
V90-V94 Water transport accidents
0.669 0.331 0.000
V70-V79 Bus occupant injured in transport accident
0.669 0.331 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.669 0.331 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.669 0.331 0.000
V40-V49 Car occupant injured in transport accident
0.669 0.331 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.669 0.331 0.000
V01-V09 Pedestrian injured in transport accident
0.669 0.331 0.000
I72 Other aneurysm
0.668 0.332 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.667 0.332 0.000
J90-J94 Other diseases of pleura
0.667 0.333 0.000
I50.1 Left ventricular failure
0.667 0.333 0.000
M22 Disorders of patella
0.667 0.333 0.000
M19.9 Arthrosis, unspecified
0.667 0.333 0.000
S88 Traumatic amputation of lower leg
0.666 0.334 0.000
S87 Crushing injury of lower leg
0.666 0.334 0.000
S86 Injury of muscle and tendon at lower leg level
0.666 0.334 0.000
S85 Injury of blood vessels at lower leg level
0.666 0.334 0.000
S84 Injury of nerves at lower leg level
0.666 0.334 0.000
N89.5 Stricture and atresia of vagina
0.665 0.335 0.000
K26.7 Chronic without haemorrhage or perforation
0.665 0.335 0.000
I46.1 Sudden cardiac death, so described
0.665 0.335 0.000
I51.9 Heart disease, unspecified
0.665 0.335 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.664 0.335 0.000
M84 Disorders of continuity of bone
0.664 0.336 0.000
Z30.1 Insertion of (intra-uterine) contraceptive device
0.664 0.336 0.000
M10 Gout
0.663 0.336 0.000
K03 Other diseases of hard tissues of teeth
0.663 0.337 0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.663 0.337 0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.663 0.337 0.000
T39.4 Antirheumatics, not elsewhere classified
0.663 0.337 0.000
T39.2 Pyrazolone derivatives
0.663 0.337 0.000
Z93.1 Gastrostomy status
0.662 0.338 0.000
B15-B19 Viral hepatitis
0.662 0.338 0.000
K52.2 Allergic and dietetic gastro-enteritis and colitis
0.662 0.338 0.000
K52.1 Toxic gastro-enteritis and colitis
0.662 0.338 0.000
K52.0 Gastro-enteritis and colitis due to radiation
0.662 0.338 0.000
I12 Hypertensive renal disease
0.661 0.339 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.661 0.339 0.000
I05 Rheumatic mitral valve diseases
0.661 0.339 0.000
F10.3 Withdrawal state
0.661 0.339 0.000
I21.2 Acute transmural myocardial infarction of other sites
0.660 0.340 0.000
Z39 Postpartum care and examination
0.660 0.340 0.000
J18.0 Bronchopneumonia, unspecified
0.660 0.340 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.660 0.340 0.000
S50 Superficial injury of forearm
0.660 0.340 0.000
M75.1 Rotator cuff syndrome
0.660 0.340 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.660 0.340 0.000
S60-S69 Injuries to the wrist and hand
0.659 0.341 0.000
C26 Malignant neoplasm of other and ill-defined digestive organs
0.658 0.342 0.000
J02 Acute pharyngitis
0.657 0.342 0.000
Z57 Occupational exposure to risk-factors
0.657 0.343 0.000
Z84 Family history of other conditions
0.656 0.344 0.000
Z81 Family history of mental and behavioural disorders
0.656 0.344 0.000
N41 Inflammatory diseases of prostate
0.656 0.344 0.000
F17.2 Dependence syndrome
0.656 0.344 0.000
M24.16 Other articular cartilage disorders (Lower leg)
0.656 0.344 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.655 0.345 0.000
M18 Arthrosis of first carpometacarpal joint
0.655 0.345 0.000
J44 Other chronic obstructive pulmonary disease
0.654 0.346 0.000
C80.0 Malignant neoplasm, primary site unknown, so stated
0.654 0.346 0.000
D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs
0.653 0.346 0.000
N25-N29 Other disorders of kidney and ureter
0.653 0.347 0.000
F20 Schizophrenia
0.653 0.347 0.000
M25.3 Other instability of joint
0.652 0.348 0.000
C18 Malignant neoplasm of colon
0.651 0.349 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.651 0.349 0.000
M33 Dermatopolymyositis
0.651 0.349 0.000
M32 Systemic lupus erythematosus
0.651 0.349 0.000
M30 Polyarteritis nodosa and related conditions
0.651 0.349 0.000
B35-B49 Mycoses
0.650 0.350 0.000
I42.7 Cardiomyopathy due to drugs and other external agents
0.650 0.350 0.000
I42.6 Alcoholic cardiomyopathy
0.650 0.350 0.000
I42.5 Other restrictive cardiomyopathy
0.650 0.350 0.000
I42.4 Endocardial fibroelastosis
0.650 0.350 0.000
I42.3 Endomyocardial (eosinophilic) disease
0.650 0.350 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.650 0.350 0.000
Q35-Q37 Cleft lip and cleft palate
0.650 0.350 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.650 0.350 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.650 0.350 0.000
M14 Arthropathies in other diseases classified elsewhere
0.649 0.351 0.000
M12 Other specific arthropathies
0.649 0.351 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.649 0.351 0.000
M08 Juvenile arthritis
0.649 0.351 0.000
C15.5 Lower third of oesophagus
0.649 0.351 0.000
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands
0.649 0.351 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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