TreeWAS – Variant ID: rs72686452

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

Hierarchical visualisation How to interpret this figure?

Showing all nodes without filtering.

Click on a node to zoom (except terminal nodes).

Download this figure in format

Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
# Top node	1.000	0.000	0.000
I20-I25 Ischaemic heart diseases	1.000	0.000	0.000
Chapter IX Diseases of the circulatory system	1.000	0.000	0.000
Chapter VI Diseases of the nervous system	1.000	0.000	0.000
G40-G47 Episodic and paroxysmal disorders	0.999	0.001	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.998	0.002	0.000
Chapter V Mental and behavioural disorders	0.998	0.002	0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.998	0.002	0.000
I20 Angina pectoris	0.996	0.004	0.000
I25 Chronic ischaemic heart disease	0.994	0.006	0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use	0.994	0.006	0.000
Chapter XX External causes of morbidity and mortality	0.991	0.009	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.990	0.010	0.000
D50-D53 Nutritional anaemias	0.989	0.011	0.000
Chapter XXI Factors influencing health status and contact with health services	0.989	0.011	0.000
I70-I79 Diseases of arteries, arterioles and capillaries	0.987	0.013	0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure	0.987	0.013	0.000
D50 Iron deficiency anaemia	0.984	0.016	0.000
Y83 Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure	0.984	0.016	0.000
F17 Mental and behavioural disorders due to use of tobacco	0.981	0.019	0.000
I21 Acute myocardial infarction	0.979	0.021	0.000
G43 Migraine	0.977	0.023	0.000
D50.9 Iron deficiency anaemia, unspecified	0.976	0.024	0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified	0.973	0.027	0.000
I20.8 Other forms of angina pectoris	0.973	0.027	0.000
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status	0.968	0.032	0.000
Z96 Presence of other functional implants	0.967	0.033	0.000
Z96.6 Presence of orthopaedic joint implants	0.966	0.034	0.000
I25.1 Atherosclerotic heart disease	0.963	0.037	0.000
I73 Other peripheral vascular diseases	0.961	0.039	0.000
Z95 Presence of cardiac and vascular implants and grafts	0.959	0.041	0.000
Chapter VIII Diseases of the ear and mastoid process	0.959	0.041	0.000
G43.9 Migraine, unspecified	0.958	0.042	0.000
M15-M19 Arthrosis	0.957	0.043	0.000
M05-M14 Inflammatory polyarthropathies	0.955	0.045	0.000
Chapter XV Pregnancy, childbirth and the puerperium	0.952	0.048	0.000
M16 Coxarthrosis [arthrosis of hip]	0.949	0.051	0.000
I73.9 Peripheral vascular disease, unspecified	0.948	0.052	0.000
Z95.1 Presence of aortocoronary bypass graft	0.946	0.054	0.000
D60-D64 Aplastic and other anaemias	0.946	0.054	0.000
M16.1 Other primary coxarthrosis	0.939	0.061	0.000
Y83.8 Other surgical procedures	0.937	0.063	0.000
T81 Complications of procedures, not elsewhere classified	0.936	0.064	0.000
Z70-Z76 Persons encountering health services in other circumstances	0.934	0.066	0.000
F17.2 Dependence syndrome	0.933	0.067	0.000
Y83.6 Removal of other organ (partial) (total)	0.932	0.068	0.000
T81.3 Disruption of operation wound, not elsewhere classified	0.930	0.070	0.000
D64 Other anaemias	0.930	0.070	0.000
F17.1 Harmful use	0.927	0.073	0.000
F10 Mental and behavioural disorders due to use of alcohol	0.925	0.075	0.000
T36-T50 Poisoning by drugs, medicaments and biological substances	0.924	0.076	0.000
H90-H95 Other disorders of ear	0.924	0.076	0.000
M13 Other arthritis	0.923	0.077	0.000
G47 Sleep disorders	0.923	0.077	0.000
Z72 Problems related to lifestyle	0.923	0.077	0.000
O20-O29 Other maternal disorders predominantly related to pregnancy	0.921	0.079	0.000
Z72.0 Tobacco use	0.921	0.079	0.000
D64.9 Anaemia, unspecified	0.918	0.082	0.000
Chapter I Certain infectious and parasitic diseases	0.918	0.082	0.000
I20.9 Angina pectoris, unspecified	0.917	0.083	0.000
Z88 Personal history of allergy to drugs, medicaments and biologocal substances	0.915	0.085	0.000
I21.4 Acute subendocardial myocardial infarction	0.914	0.086	0.000
I25.2 Old myocardial infarction	0.913	0.087	0.000
G40 Epilepsy	0.908	0.092	0.000
Z96.0 Presence of urogenital implants	0.904	0.096	0.000
Y83.2 Surgical operation with anastomosis, bypass or graft	0.899	0.101	0.000
M13.9 Arthritis, unspecified	0.898	0.102	0.000
I25.8 Other forms of chronic ischaemic heart disease	0.898	0.102	0.000
G45 Transient cerebral ischaemic attacks and related syndromes	0.897	0.103	0.000
Z82 Family history of certain disabilities and chronic diseases leading to disablement	0.894	0.106	0.000
Chapter VII Diseases of the eye and adnexa	0.890	0.110	0.000
I74 Arterial embolism and thrombosis	0.884	0.116	0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts	0.879	0.121	0.000
Z95.8 Presence of other cardiac and vascular implants and grafts	0.878	0.122	0.000
O26 Maternal care for other conditions predominantly related to pregnancy	0.876	0.124	0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.875	0.125	0.000
Z00-Z13 Persons encountering health services for examination and investigation	0.870	0.130	0.000
I21.1 Acute transmural myocardial infarction of inferior wall	0.870	0.130	0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.865	0.135	0.000
Z88.5 Personal history of allergy to narcotic agent	0.857	0.143	0.000
O26.8 Other specified pregnancy-related conditions	0.854	0.146	0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified	0.845	0.155	0.000
G90-G99 Other disorders of the nervous system	0.844	0.156	0.000
F30-F39 Mood [affective] disorders	0.844	0.156	0.000
Z95.4 Presence of other heart-valve replacement	0.842	0.158	0.000
I05-I09 Chronic rheumatic heart diseases	0.841	0.159	0.000
F40-F48 Neurotic, stress-related and somatoform disorders	0.837	0.163	0.000
B95-B98 Bacterial, viral and other infectious agents	0.836	0.164	0.000
G40.3 Generalised idiopathic epilepsy and epileptic syndromes	0.836	0.164	0.000
Z02 Examination and encounter for administrative purposes	0.835	0.165	0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit	0.834	0.166	0.000
M16.9 Coxarthrosis, unspecified	0.833	0.167	0.000
G47.3 Sleep apnoea	0.833	0.167	0.000
G50-G59 Nerve, nerve root and plexus disorders	0.832	0.168	0.000
H04 Disorders of lachrymal system	0.828	0.172	0.000
F10.1 Harmful use	0.826	0.174	0.000
M13.95 Arthritis, unspecified (Pelvic region and thigh)	0.825	0.175	0.000
S50-S59 Injuries to the elbow and forearm	0.824	0.176	0.000
O94-O99 Other obstetric conditions, not elsewhere classified	0.824	0.176	0.000
M06 Other rheumatoid arthritis	0.821	0.179	0.000
I20.1 Angina pectoris with documented spasm	0.820	0.180	0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.819	0.181	0.000
Z82.4 Family history of ischaemic heart disease and other diseases of the circulatory system	0.816	0.184	0.000
H90 Conductive and sensorineural hearing loss	0.816	0.184	0.000
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)	0.815	0.185	0.000
Z88.1 Personal history of allergy to other antibiotic agents	0.810	0.190	0.000
H91 Other hearing loss	0.810	0.190	0.000
G45.9 Transient cerebral ischaemic attack, unspecified	0.809	0.191	0.000
Z02.8 Other examinations for administrative purposes	0.809	0.191	0.000
S90-S99 Injuries to the ankle and foot	0.807	0.193	0.000
Z95.2 Presence of prosthetic heart valve	0.807	0.193	0.000
I21.9 Acute myocardial infarction, unspecified	0.806	0.194	0.000
T79-T79 Certain early complications of trauma	0.804	0.196	0.000
F10.2 Dependence syndrome	0.803	0.197	0.000
G44 Other headache syndromes	0.803	0.197	0.000
M45-M49 Spondylopathies	0.801	0.199	0.000
W00-W19 Falls	0.800	0.200	0.000
G51 Facial nerve disorders	0.796	0.204	0.000
Y83.1 Surgical operation with implant of artificial internal device	0.796	0.204	0.000
B35-B49 Mycoses	0.794	0.206	0.000
H80-H83 Diseases of inner ear	0.793	0.207	0.000
F60-F69 Disorders of adult personality and behaviour	0.791	0.209	0.000
H04.5 Stenosis and insufficiency of lachrymal passages	0.789	0.211	0.000
Y83.3 Surgical operation with formation of external stoma	0.787	0.213	0.000
O21 Excessive vomiting in pregnancy	0.786	0.214	0.000
Z00 General examination and investigation of persons without complaint or reported diagnosis	0.786	0.214	0.000
G35-G37 Demyelinating diseases of the central nervous system	0.782	0.218	0.000
Z30-Z39 Persons encountering health services in circumstances related to reproduction	0.780	0.220	0.000
D69 Purpura and other haemorrhagic conditions	0.778	0.222	0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system	0.777	0.222	0.000
H92 Otalgia and effusion of ear	0.777	0.223	0.000
T15-T19 Effects of foreign body entering through natural orifice	0.776	0.224	0.000
G47.9 Sleep disorder, unspecified	0.775	0.225	0.000
I78 Diseases of capillaries	0.771	0.229	0.000
G51.0 Bell's palsy	0.771	0.229	0.000
O60-O75 Complications of labour and delivery	0.771	0.229	0.000
S70-S79 Injuries to the hip and thigh	0.770	0.230	0.000
I20.0 Unstable angina	0.770	0.230	0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts	0.770	0.230	0.000
S40-S49 Injuries to the shoulder and upper arm	0.769	0.231	0.000
D50.8 Other iron deficiency anaemias	0.768	0.232	0.000
M20-M25 Other joint disorders	0.768	0.232	0.000
G70-G73 Diseases of myoneural junction and muscle	0.768	0.232	0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]	0.768	0.232	0.000
Z96.2 Presence of otological and audiological implants	0.767	0.233	0.000
Z89 Acquired absence of limb	0.767	0.233	0.000
T81.9 Unspecified complication of procedure	0.767	0.233	0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.765	0.235	0.000
X60-X84 Intentional self-harm	0.764	0.236	0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.763	0.237	0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.762	0.238	0.000
M14 Arthropathies in other diseases classified elsewhere	0.760	0.240	0.000
H53-H54 Visual disturbances and blindness	0.758	0.242	0.000
D52 Folate deficiency anaemia	0.756	0.244	0.000
H04.2 Epiphora	0.756	0.244	0.000
I74.5 Embolism and thrombosis of iliac artery	0.752	0.248	0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.752	0.248	0.000
M13.93 Arthritis, unspecified (Forearm)	0.751	0.249	0.000
I80 Phlebitis and thrombophlebitis	0.750	0.250	0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters	0.747	0.253	0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs	0.747	0.253	0.000
B98 Other specified infectious agents as the cause of diseases classified to other chapters	0.746	0.254	0.000
G41 Status epilepticus	0.745	0.255	0.000
G43.1 Migraine with aura [classical migraine]	0.745	0.255	0.000
S10-S19 Injuries to the neck	0.744	0.255	0.000
G40.5 Special epileptic syndromes	0.740	0.260	0.000
F80-F89 Disorders of psychological development	0.740	0.260	0.000
M13.98 Arthritis, unspecified (Other)	0.737	0.263	0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system	0.735	0.265	0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system	0.733	0.267	0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use	0.732	0.268	0.000
X40-X49 Accidental poisoning by and exposure to noxious substances	0.732	0.268	0.000
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium	0.732	0.268	0.000
T82.3 Mechanical complication of other vascular grafts	0.730	0.270	0.000
Y84 Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure	0.730	0.270	0.000
M13.94 Arthritis, unspecified (Hand)	0.730	0.270	0.000
H60-H62 Diseases of external ear	0.729	0.271	0.000
Z88.0 Personal history of allergy to penicillin	0.729	0.271	0.000
H91.9 Hearing loss, unspecified	0.729	0.271	0.000
Chapter XXII Codes for special purposes	0.728	0.272	0.000
Y60-Y69 Misadventures to patients during surgical and medical care	0.727	0.273	0.000
D80-D89 Certain disorders involving the immune mechanism	0.725	0.275	0.000
I24 Other acute ischaemic heart diseases	0.725	0.275	0.000
T88 Other complications of surgical and medical care, not elsewhere classified	0.724	0.275	0.000
G45.3 Amaurosis fugax	0.724	0.276	0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions	0.724	0.276	0.000
M13.96 Arthritis, unspecified (Lower leg)	0.724	0.276	0.000
Z96.7 Presence of other bone and tendon implants	0.723	0.277	0.000
O85-O92 Complications predominantly related to the puerperium	0.723	0.277	0.000
G93 Other disorders of brain	0.722	0.278	0.000
H90.5 Sensorineural hearing loss, unspecified	0.721	0.279	0.000
G80-G83 Cerebral palsy and other paralytic syndromes	0.718	0.282	0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.717	0.283	0.000
Chapter XVI Certain conditions originating in the perinatal period	0.717	0.283	0.000
I23 Certain current complications following acute myocardial infarction	0.717	0.283	0.000
I00-I02 Acute rheumatic fever	0.717	0.283	0.000
G00-G09 Inflammatory diseases of the central nervous system	0.717	0.283	0.000
G46 Vascular syndromes of brain in cerebrovascular diseases	0.716	0.284	0.000
I21.0 Acute transmural myocardial infarction of anterior wall	0.716	0.284	0.000
D55-D59 Haemolytic anaemias	0.716	0.284	0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence	0.716	0.284	0.000
F70-F79 Mental retardation	0.716	0.284	0.000
T33-T35 Frostbite	0.715	0.285	0.000
T26-T28 Burns and corrosions confined to eye and internal organs	0.715	0.285	0.000
T20-T25 Burns and corrosions of external body surface, specified by site	0.715	0.285	0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.715	0.285	0.000
T00-T07 Injuries involving multiple body regions	0.715	0.285	0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities	0.715	0.285	0.000
T92 Sequelae of injuries of upper limb	0.713	0.287	0.000
I25.6 Silent myocardial ischaemia	0.713	0.287	0.000
I25.4 Coronary artery aneurysm	0.713	0.287	0.000
I25.3 Aneurysm of heart	0.713	0.287	0.000
I25.0 Atherosclerotic cardiovascular disease, so described	0.713	0.287	0.000
I08 Multiple valve diseases	0.713	0.287	0.000
F19 Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances	0.712	0.287	0.000
F18 Mental and behavioural disorders due to use of volatile solvents	0.712	0.287	0.000
F16 Mental and behavioural disorders due to use of hallucinogens	0.712	0.287	0.000
F15 Mental and behavioural disorders due to use of other stimulants, including caffeine	0.712	0.287	0.000
F14 Mental and behavioural disorders due to use of cocaine	0.712	0.287	0.000
F13 Mental and behavioural disorders due to use of sedatives or hypnotics	0.712	0.287	0.000
F12 Mental and behavioural disorders due to use of cannabinoids	0.712	0.287	0.000
F11 Mental and behavioural disorders due to use of opioids	0.712	0.287	0.000
B95.6 Staphylococcus aureus as the cause of diseases classified to other chapters	0.711	0.289	0.000
Y35-Y36 Legal intervention and operations of war	0.711	0.289	0.000
Y10-Y34 Event of undetermined intent	0.711	0.289	0.000
Y00-Y09 Assault	0.711	0.289	0.000
X85-X99 Assault	0.711	0.289	0.000
X58-X59 Accidental exposure to other and unspecified factors	0.711	0.289	0.000
X50-X57 Overexertion, travel and privation	0.711	0.289	0.000
X30-X39 Exposure to forces of nature	0.711	0.289	0.000
X20-X29 Contact with venomous animals and plants	0.711	0.289	0.000
X10-X19 Contact with heat and hot substances	0.711	0.289	0.000
X00-X09 Exposure to smoke, fire and flames	0.711	0.289	0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure	0.711	0.289	0.000
W75-W84 Other accidental threats to breathing	0.711	0.289	0.000
W65-W74 Accidental drowning and submersion	0.711	0.289	0.000
W50-W64 Exposure to animate mechanical forces	0.711	0.289	0.000
V98-V99 Other and unspecified transport accidents	0.711	0.289	0.000
V95-V97 Air and space transport accidents	0.711	0.289	0.000
V90-V94 Water transport accidents	0.711	0.289	0.000
V80-V89 Other land transport accidents	0.711	0.289	0.000
V70-V79 Bus occupant injured in transport accident	0.711	0.289	0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident	0.711	0.289	0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident	0.711	0.289	0.000
V40-V49 Car occupant injured in transport accident	0.711	0.289	0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident	0.711	0.289	0.000
V01-V09 Pedestrian injured in transport accident	0.711	0.289	0.000
M60-M63 Disorders of muscles	0.710	0.290	0.000
M00-M03 Infectious arthropathies	0.710	0.290	0.000
D53 Other nutritional anaemias	0.709	0.291	0.000
M91-M94 Chondropathies	0.709	0.291	0.000
V20-V29 Motorcycle rider injured in transport accident	0.708	0.292	0.000
I21.2 Acute transmural myocardial infarction of other sites	0.708	0.292	0.000
Z88.4 Personal history of allergy to anaesthetic agent	0.708	0.292	0.000
Z13 Special screening examination for other diseases and disorders	0.708	0.292	0.000
Z97 Presence of other devices	0.707	0.293	0.000
B97 Viral agents as the cause of diseases classified to other chapters	0.706	0.294	0.000
D50.1 Sideropenic dysphagia	0.705	0.294	0.000
Y83.5 Amputation of limb(s)	0.705	0.294	0.000
B90-B94 Sequelae of infectious and parasitic diseases	0.705	0.295	0.000
B37 Candidiasis	0.705	0.295	0.000
M40-M43 Deforming dorsopathies	0.704	0.296	0.000
G95 Other diseases of spinal cord	0.704	0.296	0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body	0.704	0.296	0.000
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts	0.704	0.296	0.000
F17.9 Unspecified mental and behavioural disorder	0.703	0.297	0.000
F17.8 Other mental and behavioural disorders	0.703	0.297	0.000
F17.7 Residual and late-onset psychotic disorder	0.703	0.297	0.000
F17.6 Amnesic syndrome	0.703	0.297	0.000
F17.5 Psychotic disorder	0.703	0.297	0.000
F17.4 Withdrawal state with delirium	0.703	0.297	0.000
F17.3 Withdrawal state	0.703	0.297	0.000
F17.0 Acute intoxication	0.703	0.297	0.000
F41 Other anxiety disorders	0.703	0.297	0.000
F00-F09 Organic, including symptomatic, mental disorders	0.702	0.297	0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality	0.702	0.298	0.000
I21.X Presumed acute myicardial infaction (unconfirmed)	0.702	0.298	0.000
I21.3 Acute transmural myocardial infarction of unspecified site	0.702	0.298	0.000
M80-M85 Disorders of bone density and structure	0.701	0.298	0.001
G40.2 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures	0.701	0.299	0.000
I71 Aortic aneurysm and dissection	0.701	0.299	0.000
G43.8 Other migraine	0.700	0.300	0.000
G43.3 Complicated migraine	0.700	0.300	0.000
G43.2 Status migrainosus	0.700	0.300	0.000
G43.0 Migraine without aura [common migraine]	0.700	0.300	0.000
O24 Diabetes mellitus in pregnancy	0.700	0.300	0.000
I80.1 Phlebitis and thrombophlebitis of femoral vein	0.700	0.300	0.000
I72 Other aneurysm	0.699	0.301	0.000
T87 Complications peculiar to reattachment and amputation	0.698	0.302	0.000
T86 Failure and rejection of transplanted organs and tissues	0.698	0.302	0.000
T80 Complications following infusion, transfusion and therapeutic injection	0.698	0.302	0.000
Z82.5 Family history of asthma and other chronic lower respiratory diseases	0.698	0.302	0.000
M17 Gonarthrosis [arthrosis of knee]	0.698	0.302	0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders	0.697	0.303	0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors	0.696	0.304	0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.696	0.304	0.000
Z72.2 Drug use	0.695	0.304	0.000
T85 Complications of other internal prosthetic devices, implants and grafts	0.695	0.305	0.000
Z95.9 Presence of cardiac and vascular implant and graft, unspecified	0.694	0.305	0.000
H04.1 Other disorders of lachrymal gland	0.694	0.306	0.000
Z84 Family history of other conditions	0.694	0.306	0.000
Z81 Family history of mental and behavioural disorders	0.694	0.306	0.000
Z96.9 Presence of functional implant, unspecified	0.693	0.307	0.000
Z96.5 Presence of tooth-root and mandibular implants	0.693	0.307	0.000
Z96.4 Presence of endocrine implants	0.693	0.307	0.000
Z96.3 Presence of artificial larynx	0.693	0.307	0.000
Chapter II Neoplasms	0.693	0.307	0.000
H10-H13 Disorders of conjunctiva	0.693	0.307	0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.692	0.308	0.000
M35 Other systemic involvement of connective tissue	0.692	0.308	0.000
T51 Toxic effect of alcohol	0.692	0.308	0.000
B20-B24 Human immunodeficiency virus [HIV] disease	0.691	0.308	0.000
O80-O84 Delivery	0.691	0.309	0.000
M70-M79 Other soft tissue disorders	0.690	0.310	0.000
I73.8 Other specified peripheral vascular diseases	0.689	0.311	0.000
I73.1 Thromboangiitis obliterans [Buerger]	0.689	0.311	0.000
I84 Haemorrhoids	0.687	0.313	0.000
T82.5 Mechanical complication of other cardiac and vascular devices and implants	0.687	0.313	0.000
I25.5 Ischaemic cardiomyopathy	0.687	0.313	0.000
Z88.9 Personal history of allergy to unspecified drugs, medicaments and biological substances	0.687	0.313	0.000
M13.91 Arthritis, unspecified (Shoulder region)	0.687	0.313	0.000
M15 Polyarthrosis	0.686	0.314	0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction	0.686	0.314	0.000
Z00.0 General medical examination	0.686	0.314	0.000
M24 Other specific joint derangements	0.685	0.315	0.000
M12 Other specific arthropathies	0.685	0.315	0.000
M09 Juvenile arthritis in diseases classified elsewhere	0.685	0.315	0.000
M08 Juvenile arthritis	0.685	0.315	0.000
H81 Disorders of vestibular function	0.684	0.316	0.000
F31 Bipolar affective disorder	0.684	0.316	0.000
M13.0 Polyarthritis, unspecified	0.683	0.316	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.683	0.317	0.000
T91 Sequelae of injuries of neck and trunk	0.682	0.318	0.000
M86-M90 Other osteopathies	0.682	0.318	0.000
T93 Sequelae of injuries of lower limb	0.682	0.318	0.000
B98.0 Helicobacter pylori [H.pylori] as the cause of diseases classified to other chapters	0.681	0.319	0.000
T81.4 Infection following a procedure, not elsewhere classified	0.681	0.319	0.000
M16.6 Other secondary coxarthrosis, bilateral	0.681	0.319	0.000
M16.5 Other posttraumatic coxarthrosis	0.681	0.319	0.000
M16.4 Posttraumatic coxarthrosis, bilateral	0.681	0.319	0.000
M16.3 Other dysplastic coxarthrosis	0.681	0.319	0.000
M16.2 Coxarthrosis resulting from dysplasia, bilateral	0.681	0.319	0.000
F30 Manic episode	0.680	0.320	0.000
B15-B19 Viral hepatitis	0.680	0.320	0.000
Y83.0 Surgical operation with transplant of whole organ	0.680	0.320	0.000
H92.1 Otorrhoea	0.680	0.320	0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.679	0.320	0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]	0.678	0.322	0.000
H93 Other disorders of ear, not elsewhere classified	0.677	0.323	0.000
C15-C26 Malignant neoplasms of digestive organs	0.677	0.323	0.000
I74.2 Embolism and thrombosis of arteries of the upper extremities	0.677	0.323	0.000
I22 Subsequent myocardial infarction	0.676	0.323	0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases	0.675	0.324	0.000
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts	0.675	0.325	0.000
M06.0 Seronegative rheumatoid arthritis	0.674	0.326	0.000
F99-F99 Unspecified mental disorder	0.673	0.327	0.000
O21.9 Vomiting of pregnancy, unspecified	0.673	0.327	0.000
I84.2 Internal haemorrhoids without complication	0.672	0.328	0.000
I70 Atherosclerosis	0.672	0.328	0.000
T81.7 Vascular complications following a procedure, not elsewhere classified	0.671	0.329	0.000
T81.6 Acute reaction to foreign substance accidentally left during a procedure	0.671	0.329	0.000
T81.5 Foreign body accidentally left in body cavity or operation wound following a procedure	0.671	0.329	0.000
T81.1 Shock during or resulting from a procedure, not elsewhere classified	0.671	0.329	0.000
F33 Recurrent depressive disorder	0.671	0.329	0.000
S00-S09 Injuries to the head	0.670	0.330	0.000
Z76 Persons encountering health services in other circumstances	0.670	0.330	0.000
Z70 Counselling related to sexual attitude, behaviour and orientation	0.670	0.330	0.000
Z88.7 Personal history of allergy to serum and vaccine	0.670	0.330	0.000
M06.9 Rheumatoid arthritis, unspecified	0.669	0.331	0.000
W20-W49 Exposure to inanimate mechanical forces	0.668	0.332	0.000
D64.8 Other specified anaemias	0.666	0.333	0.000
D64.4 Congenital dyserythropoietic anaemia	0.666	0.333	0.000
D64.3 Other sideroblastic anaemias	0.666	0.333	0.000
D64.2 Secondary sideroblastic anaemia due to drugs and toxins	0.666	0.333	0.000
D64.1 Secondary sideroblastic anaemia due to disease	0.666	0.333	0.000
D64.0 Hereditary sideroblastic anaemia	0.666	0.333	0.000
Z88.6 Personal history of allergy to analgesic agent	0.666	0.334	0.000
Z82.0 Family history of epilepsy and other diseases of the nervous system	0.666	0.334	0.000
T83.3 Mechanical complication of intra-uterine contraceptive device	0.666	0.334	0.000
T79 Certain early complications of trauma, not elsewhere classified	0.666	0.334	0.000
Z83 Family history of other specific disorders	0.665	0.335	0.000
G40.6 Grand mal seizures, unspecified (with or without petit mal)	0.665	0.335	0.000
M13.99 Arthritis, unspecified (Site unspecified)	0.664	0.336	0.000
H46-H48 Disorders of optic nerve and visual pathways	0.664	0.336	0.000
F10.9 Unspecified mental and behavioural disorder	0.663	0.337	0.000
F10.8 Other mental and behavioural disorders	0.663	0.337	0.000
F10.7 Residual and late-onset psychotic disorder	0.663	0.337	0.000
F10.6 Amnesic syndrome	0.663	0.337	0.000
F10.5 Psychotic disorder	0.663	0.337	0.000
F10.4 Withdrawal state with delirium	0.663	0.337	0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.662	0.337	0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.662	0.337	0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.662	0.337	0.000
T46 Poisoning by agents primarily affecting the cardiovascular system	0.662	0.337	0.000
T41 Poisoning by anaesthetics and therapeutic gases	0.662	0.337	0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.662	0.337	0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.662	0.337	0.000
T36 Poisoning by systemic antibiotics	0.662	0.337	0.000
M16.7 Other secondary coxarthrosis	0.662	0.338	0.000
H95 Postprocedural disorders of ear and mastoid process, not elsewhere classified	0.662	0.338	0.000
H94 Other disorders of ear in diseases classified elsewhere	0.662	0.338	0.000
I25.9 Chronic ischaemic heart disease, unspecified	0.662	0.338	0.000
M13.8 Other specified arthritis	0.662	0.338	0.000
M13.1 Monoarthritis, not elsewhere classified	0.662	0.338	0.000
G47.8 Other sleep disorders	0.662	0.338	0.000
G47.4 Narcolepsy and cataplexy	0.662	0.338	0.000
G47.2 Disorders of the sleep-wake schedule	0.662	0.338	0.000
G47.1 Disorders of excessive somnolence [hypersomnias]	0.662	0.338	0.000
Z72.9 Problem related to lifestyle, unspecified	0.662	0.338	0.000
Z72.8 Other problems related to lifestyle	0.662	0.338	0.000
Z72.6 Gambling and betting	0.662	0.338	0.000
Z72.5 High-risk sexual behaviour	0.662	0.338	0.000
Z72.4 Inappropriate diet and eating habits	0.662	0.338	0.000
Z72.3 Lack of physical exercise	0.662	0.338	0.000
H04.8 Other disorders of lachrymal system	0.662	0.338	0.000
S80-S89 Injuries to the knee and lower leg	0.662	0.338	0.000
F10.0 Acute intoxication	0.661	0.339	0.000
O29 Complications of anaesthesia during pregnancy	0.660	0.339	0.000
O28 Abnormal findings on antenatal screening of mother	0.660	0.339	0.000
O23 Infections of genito-urinary tract in pregnancy	0.660	0.339	0.000
O22 Venous complications in pregnancy	0.660	0.339	0.000
O25 Malnutrition in pregnancy	0.660	0.339	0.000
G54 Nerve root and plexus disorders	0.660	0.340	0.000
D69.3 Idiopathic thrombocytopenic purpura	0.659	0.341	0.000
H55-H59 Other disorders of eye and adnexa	0.659	0.341	0.000
B99-B99 Other infectious diseases	0.658	0.342	0.000
B85-B89 Pediculosis, acariasis and other infestations	0.658	0.342	0.000
B65-B83 Helminthiases	0.658	0.342	0.000
B50-B64 Protozoal diseases	0.658	0.342	0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers	0.658	0.342	0.000
A80-A89 Viral infections of the central nervous system	0.658	0.342	0.000
A75-A79 Rickettsioses	0.658	0.342	0.000
A70-A74 Other diseases caused by chlamydiae	0.658	0.342	0.000
A65-A69 Other spirochaetal diseases	0.658	0.342	0.000
A50-A64 Infections with a predominantly sexual mode of transmission	0.658	0.342	0.000
A20-A28 Certain zoonotic bacterial diseases	0.658	0.342	0.000
A15-A19 Tuberculosis	0.658	0.342	0.000
M65-M68 Disorders of synovium and tendon	0.657	0.342	0.000
H40-H42 Glaucoma	0.657	0.343	0.000
M21 Other acquired deformities of limbs	0.657	0.343	0.000
O72 Postpartum haemorrhage	0.655	0.345	0.000
Y83.9 Surgical procedure, unspecified	0.652	0.347	0.000
Z00.6 Examination for normal comparison and control in clinical research programme	0.652	0.348	0.000
D69.0 Allergic purpura	0.651	0.349	0.000
G40.8 Other epilepsy	0.651	0.349	0.000
G40.7 Petit mal, unspecified, without grand mal seizures	0.651	0.349	0.000
G40.4 Other generalised epilepsy and epileptic syndromes	0.651	0.349	0.000
G40.1 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures	0.651	0.349	0.000
G40.0 Localisation-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localised onset	0.651	0.349	0.000
D68 Other coagulation defects	0.650	0.350	0.000
I87 Other disorders of veins	0.649	0.351	0.000
M17.0 Primary gonarthrosis, bilateral	0.649	0.351	0.000
Z82.3 Family history of stroke	0.647	0.353	0.000
I77 Other disorders of arteries and arterioles	0.647	0.353	0.000
Z86 Personal history of certain other diseases	0.647	0.353	0.000
F45 Somatoform disorders	0.647	0.353	0.000
H53 Visual disturbances	0.646	0.354	0.000
M35.0 Sicca syndrome [Sjogren]	0.646	0.354	0.000
G44.8 Other specified headache syndromes	0.646	0.354	0.000
F10.3 Withdrawal state	0.645	0.355	0.000
G47.0 Disorders of initiating and maintaining sleep [insomnias]	0.645	0.355	0.000
M45 Ankylosing spondylitis	0.644	0.356	0.000
S51 Open wound of forearm	0.644	0.356	0.000
M13.92 Arthritis, unspecified (Upper arm)	0.644	0.356	0.000
Z34 Supervision of normal pregnancy	0.644	0.356	0.000
M05 Seropositive rheumatoid arthritis	0.644	0.356	0.000
S99 Other and unspecified injuries of ankle and foot	0.643	0.357	0.000
G45.8 Other transient cerebral ischaemic attacks and related syndromes	0.643	0.357	0.000
G45.2 Multiple and bilateral precerebral artery syndromes	0.643	0.357	0.000
G45.1 Carotid artery syndrome (hemispheric)	0.643	0.357	0.000
G45.0 Vertebro-basilar artery syndrome	0.643	0.357	0.000
F60 Specific personality disorders	0.642	0.358	0.000
F41.2 Mixed anxiety and depressive disorder	0.641	0.359	0.000
Z82.8 Family history of other disabilities and chronic diseases leading to disablement, not elsewhere classified	0.641	0.359	0.000
Z82.7 Family history of congenital malformations, deformations and chromosomal abnormalities	0.641	0.359	0.000
Z82.6 Family history of arthritis and other diseases of the musculoskeletal system and connective tissue	0.641	0.359	0.000
Z82.2 Family history of deafness and hearing loss	0.641	0.359	0.000
Z82.1 Family history of blindness and visual loss	0.641	0.359	0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs	0.640	0.360	0.000
S30 Superficial injury of abdomen, lower back and pelvis	0.640	0.360	0.000
M11 Other crystal arthropathies	0.640	0.360	0.000
O99.0 Anaemia complicating pregnancy, childbirth and the puerperium	0.636	0.364	0.000
I78.0 Hereditary haemorrhagic telangiectasia	0.636	0.364	0.000
I82 Other venous embolism and thrombosis	0.635	0.365	0.000
I74.9 Embolism and thrombosis of unspecified artery	0.634	0.366	0.000
I74.8 Embolism and thrombosis of other arteries	0.634	0.366	0.000
I74.4 Embolism and thrombosis of arteries of extremities, unspecified	0.634	0.366	0.000
I74.1 Embolism and thrombosis of other and unspecified parts of aorta	0.634	0.366	0.000
I74.0 Embolism and thrombosis of abdominal aorta	0.634	0.366	0.000
T43.0 Tricyclic and tetracyclic antidepressants	0.634	0.366	0.000
S50 Superficial injury of forearm	0.633	0.367	0.000
I07 Rheumatic tricuspid valve diseases	0.631	0.368	0.000
G53 Cranial nerve disorders in diseases classified elsewhere	0.631	0.369	0.000
Z88.2 Personal history of allergy to sulphonamides	0.630	0.370	0.000
T82.9 Unspecified complication of cardiac and vascular prosthetic device, implant and graft	0.630	0.370	0.000
T82.6 Infection and inflammatory reaction due to cardiac valve prosthesis	0.630	0.370	0.000
T82.4 Mechanical complication of vascular dialysis catheter	0.630	0.370	0.000
T82.2 Mechanical complication of coronary artery bypass and valve grafts	0.630	0.370	0.000
T82.0 Mechanical complication of heart valve prosthesis	0.630	0.370	0.000
W18 Other fall on same level	0.630	0.370	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations