TreeWAS – Variant ID: rs72813183

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
# Top node	0.891	0.109	0.000
Chapter II Neoplasms	0.884	0.116	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.876	0.124	0.000
C43-C44 Melanoma and other malignant neoplasms of skin	0.863	0.137	0.000
C44 Other malignant neoplasms of skin	0.849	0.151	0.000
Chapter X Diseases of the respiratory system	0.846	0.154	0.000
D10-D36 Benign neoplasms	0.841	0.159	0.000
M70-M79 Other soft tissue disorders	0.828	0.172	0.000
D12 Benign neoplasm of colon, rectum, anus and anal canal	0.809	0.191	0.000
C44.3 Skin of other and unspecified parts of face	0.798	0.202	0.000
M75 Shoulder lesions	0.792	0.208	0.000
J90-J94 Other diseases of pleura	0.790	0.210	0.000
Chapter XV Pregnancy, childbirth and the puerperium	0.780	0.220	0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	0.777	0.223	0.000
Chapter V Mental and behavioural disorders	0.765	0.235	0.000
Chapter XII Diseases of the skin and subcutaneous tissue	0.760	0.240	0.000
J90 Pleural effusion, not elsewhere classified	0.750	0.250	0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems	0.736	0.264	0.000
D12.3 Transverse colon	0.723	0.276	0.000
M05-M14 Inflammatory polyarthropathies	0.723	0.277	0.000
M45-M49 Spondylopathies	0.722	0.278	0.000
Chapter VII Diseases of the eye and adnexa	0.719	0.281	0.000
D12.5 Sigmoid colon	0.712	0.288	0.000
M75.4 Impingement syndrome of shoulder	0.712	0.288	0.000
M20-M25 Other joint disorders	0.707	0.293	0.000
D12.4 Descending colon	0.702	0.298	0.000
C64-C68 Malignant neoplasms of urinary tract	0.698	0.302	0.000
C44.4 Skin of scalp and neck	0.696	0.304	0.000
Chapter VIII Diseases of the ear and mastoid process	0.695	0.305	0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems	0.691	0.309	0.000
C44.6 Skin of upper limb, including shoulder	0.691	0.309	0.000
J09-J18 Influenza and pneumonia	0.691	0.309	0.000
M80-M85 Disorders of bone density and structure	0.678	0.322	0.000
Chapter IX Diseases of the circulatory system	0.676	0.323	0.001
M75.0 Adhesive capsulitis of shoulder	0.676	0.323	0.000
C15-C26 Malignant neoplasms of digestive organs	0.671	0.329	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.669	0.330	0.000
C44.2 Skin of ear and external auricular canal	0.666	0.334	0.000
J40-J47 Chronic lower respiratory diseases	0.664	0.336	0.000
C44.5 Skin of trunk	0.660	0.340	0.000
J95-J99 Other diseases of the respiratory system	0.659	0.341	0.000
F40-F48 Neurotic, stress-related and somatoform disorders	0.654	0.346	0.000
D25 Leiomyoma of uterus	0.653	0.347	0.000
M75.1 Rotator cuff syndrome	0.650	0.350	0.000
C44.7 Skin of lower limb, including hip	0.649	0.351	0.000
Chapter XIV Diseases of the genitourinary system	0.647	0.353	0.000
Chapter VI Diseases of the nervous system	0.647	0.353	0.000
I60-I69 Cerebrovascular diseases	0.644	0.356	0.000
Chapter XXII Codes for special purposes	0.639	0.361	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.639	0.361	0.000
Chapter XVI Certain conditions originating in the perinatal period	0.639	0.361	0.000
D37-D48 Neoplasms of uncertain or unknown behaviour	0.633	0.366	0.000
D00-D09 In situ neoplasms	0.633	0.366	0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites	0.633	0.366	0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue	0.633	0.366	0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands	0.633	0.366	0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system	0.633	0.366	0.000
C51-C58 Malignant neoplasms of female genital organs	0.633	0.366	0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue	0.633	0.366	0.000
C40-C41 Malignant neoplasms of bone and articular cartilage	0.633	0.366	0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx	0.633	0.366	0.000
O60-O75 Complications of labour and delivery	0.633	0.367	0.000
R29 Other symptoms and signs involving the nervous and musculoskeletal systems	0.630	0.370	0.000
R07 Pain in throat and chest	0.628	0.372	0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.628	0.372	0.000
M91-M94 Chondropathies	0.628	0.372	0.000
M86-M90 Other osteopathies	0.628	0.372	0.000
M65-M68 Disorders of synovium and tendon	0.628	0.372	0.000
M60-M63 Disorders of muscles	0.628	0.372	0.000
M40-M43 Deforming dorsopathies	0.628	0.372	0.000
M00-M03 Infectious arthropathies	0.628	0.372	0.000
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue	0.627	0.373	0.000
Chapter I Certain infectious and parasitic diseases	0.625	0.375	0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs	0.624	0.375	0.000
R00 Abnormalities of heart beat	0.623	0.377	0.000
C43 Malignant melanoma of skin	0.619	0.381	0.000
O20-O29 Other maternal disorders predominantly related to pregnancy	0.618	0.382	0.000
M15-M19 Arthrosis	0.617	0.382	0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites	0.616	0.384	0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis	0.615	0.385	0.000
M72 Fibroblastic disorders	0.615	0.385	0.000
F00-F09 Organic, including symptomatic, mental disorders	0.610	0.390	0.000
M50-M54 Other dorsopathies	0.609	0.391	0.000
C44.9 Malignant neoplasm of skin, unspecified	0.609	0.391	0.000
C44.8 Overlapping lesion of skin	0.609	0.391	0.000
C44.1 Skin of eyelid, including canthus	0.609	0.391	0.000
C44.0 Skin of lip	0.609	0.391	0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract	0.606	0.394	0.000
J80-J84 Other respiratory diseases principally affecting the interstitium	0.606	0.394	0.000
J60-J70 Lung diseases due to external agents	0.606	0.394	0.000
J00-J06 Acute upper respiratory infections	0.606	0.394	0.000
D22 Melanocytic naevi	0.604	0.396	0.000
M47 Spondylosis	0.604	0.396	0.000
D36 Benign neoplasm of other and unspecified sites	0.603	0.397	0.000
D35 Benign neoplasm of other and unspecified endocrine glands	0.603	0.397	0.000
D33 Benign neoplasm of brain and other parts of central nervous system	0.603	0.397	0.000
D32 Benign neoplasm of meninges	0.603	0.397	0.000
D31 Benign neoplasm of eye and adnexa	0.603	0.397	0.000
D30 Benign neoplasm of urinary organs	0.603	0.397	0.000
D29 Benign neoplasm of male genital organs	0.603	0.397	0.000
D28 Benign neoplasm of other and unspecified female genital organs	0.603	0.397	0.000
D26 Other benign neoplasms of uterus	0.603	0.397	0.000
D23 Other benign neoplasms of skin	0.603	0.397	0.000
D21 Other benign neoplasms of connective and other soft tissue	0.603	0.397	0.000
D20 Benign neoplasm of soft tissue of retroperitoneum and peritoneum	0.603	0.397	0.000
D19 Benign neoplasm of mesothelial tissue	0.603	0.397	0.000
D18 Haemangioma and lymphangioma, any site	0.603	0.397	0.000
D16 Benign neoplasm of bone and articular cartilage	0.603	0.397	0.000
D15 Benign neoplasm of other and unspecified intrathoracic organs	0.603	0.397	0.000
D14 Benign neoplasm of middle ear and respiratory system	0.603	0.397	0.000
D13 Benign neoplasm of other and ill-defined parts of digestive system	0.603	0.397	0.000
D11 Benign neoplasm of major salivary glands	0.603	0.397	0.000
D10 Benign neoplasm of mouth and pharynx	0.603	0.397	0.000
D34 Benign neoplasm of thyroid gland	0.603	0.397	0.000
D27 Benign neoplasm of ovary	0.603	0.397	0.000
D12.2 Ascending colon	0.602	0.398	0.000
R02 Gangrene, not elsewhere classified	0.598	0.402	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.594	0.406	0.000
L00-L08 Infections of the skin and subcutaneous tissue	0.594	0.406	0.000
M77 Other enthesopathies	0.594	0.406	0.000
M76 Enthesopathies of lower limb, excluding foot	0.594	0.406	0.000
M73 Soft tissue disorders in diseases classified elsewhere	0.594	0.406	0.000
M71 Other bursopathies	0.594	0.406	0.000
M70 Soft tissue disorders related to use, overuse and pressure	0.594	0.406	0.000
I63 Cerebral infarction	0.590	0.410	0.000
D12.6 Colon, unspecified	0.590	0.410	0.000
M13 Other arthritis	0.590	0.410	0.000
M79 Other soft tissue disorders, not elsewhere classified	0.588	0.412	0.000
O00-O08 Pregnancy with abortive outcome	0.587	0.413	0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.587	0.413	0.000
D24 Benign neoplasm of breast	0.580	0.419	0.000
D12.9 Anus and anal canal	0.580	0.420	0.000
D12.7 Rectosigmoid junction	0.580	0.420	0.000
D12.1 Appendix	0.580	0.420	0.000
D12.0 Caecum	0.580	0.420	0.000
J18 Pneumonia, organism unspecified	0.580	0.420	0.000
I30-I52 Other forms of heart disease	0.578	0.422	0.000
D17 Benign lipomatous neoplasm	0.577	0.423	0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems	0.576	0.423	0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit	0.576	0.424	0.000
O80-O84 Delivery	0.576	0.424	0.000
F41 Other anxiety disorders	0.575	0.425	0.000
R29.8 Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems	0.575	0.425	0.000
J30-J39 Other diseases of upper respiratory tract	0.570	0.430	0.000
N17-N19 Renal failure	0.569	0.431	0.000
L20-L30 Dermatitis and eczema	0.568	0.432	0.000
M22 Disorders of patella	0.568	0.432	0.000
M75.8 Other shoulder lesions	0.568	0.432	0.000
M75.9 Shoulder lesion, unspecified	0.568	0.432	0.000
M75.5 Bursitis of shoulder	0.568	0.432	0.000
M75.3 Calcific tendinitis of shoulder	0.568	0.432	0.000
M75.2 Bicipital tendinitis	0.568	0.432	0.000
L40-L45 Papulosquamous disorders	0.567	0.433	0.000
J94 Other pleural conditions	0.566	0.433	0.000
J93 Pneumothorax	0.566	0.433	0.000
J92 Pleural plaque	0.566	0.433	0.000
J91 Pleural effusion in conditions classified elsewhere	0.566	0.433	0.000
C67 Malignant neoplasm of bladder	0.565	0.435	0.000
F30-F39 Mood [affective] disorders	0.565	0.435	0.000
R05 Cough	0.562	0.438	0.000
Chapter XX External causes of morbidity and mortality	0.560	0.440	0.000
O94-O99 Other obstetric conditions, not elsewhere classified	0.559	0.441	0.000
O85-O92 Complications predominantly related to the puerperium	0.559	0.441	0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium	0.559	0.441	0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis	0.558	0.442	0.000
R95-R99 Ill-defined and unknown causes of mortality	0.557	0.443	0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis	0.557	0.443	0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis	0.557	0.443	0.000
R47-R49 Symptoms and signs involving speech and voice	0.557	0.443	0.000
H65-H75 Diseases of middle ear and mastoid	0.557	0.443	0.000
R00.1 Bradycardia, unspecified	0.556	0.444	0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour	0.554	0.446	0.000
I63.9 Cerebral infarction, unspecified	0.552	0.448	0.000
F99-F99 Unspecified mental disorder	0.549	0.451	0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence	0.549	0.451	0.000
F80-F89 Disorders of psychological development	0.549	0.451	0.000
F70-F79 Mental retardation	0.549	0.451	0.000
F60-F69 Disorders of adult personality and behaviour	0.549	0.451	0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors	0.549	0.451	0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders	0.549	0.451	0.000
R04 Haemorrhage from respiratory passages	0.548	0.452	0.000
L50-L54 Urticaria and erythema	0.545	0.455	0.000
L10-L14 Bullous disorders	0.545	0.455	0.000
M10 Gout	0.545	0.455	0.000
R03 Abnormal blood-pressure reading, without diagnosis	0.544	0.456	0.000
H30-H36 Disorders of choroid and retina	0.541	0.459	0.000
M81 Osteoporosis without pathological fracture	0.536	0.463	0.000
M23 Internal derangement of knee	0.536	0.463	0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.536	0.464	0.000
L80-L99 Other disorders of the skin and subcutaneous tissue	0.534	0.466	0.000
M48 Other spondylopathies	0.532	0.468	0.000
L57 Skin changes due to chronic exposure to nonionising radiation	0.531	0.469	0.000
J44 Other chronic obstructive pulmonary disease	0.531	0.469	0.000
J20-J22 Other acute lower respiratory infections	0.531	0.469	0.000
M06 Other rheumatoid arthritis	0.530	0.470	0.000
L60-L75 Disorders of skin appendages	0.529	0.471	0.000
R09 Other symptoms and signs involving the circulatory and respiratory systems	0.528	0.472	0.000
R01 Cardiac murmurs and other cardiac sounds	0.528	0.472	0.000
H40-H42 Glaucoma	0.526	0.474	0.000
J98 Other respiratory disorders	0.525	0.475	0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue	0.522	0.478	0.000
I67 Other cerebrovascular diseases	0.521	0.478	0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction	0.521	0.479	0.000
M14 Arthropathies in other diseases classified elsewhere	0.518	0.481	0.000
M12 Other specific arthropathies	0.518	0.481	0.000
M11 Other crystal arthropathies	0.518	0.481	0.000
M09 Juvenile arthritis in diseases classified elsewhere	0.518	0.481	0.000
M08 Juvenile arthritis	0.518	0.481	0.000
M07 Psoriatic and enteropathic arthropathies	0.518	0.481	0.000
M05 Seropositive rheumatoid arthritis	0.518	0.481	0.000
C18 Malignant neoplasm of colon	0.518	0.482	0.000
D25.0 Submucous leiomyoma of uterus	0.518	0.482	0.000
M49 Spondylopathies in diseases classified elsewhere	0.518	0.482	0.000
M46 Other inflammatory spondylopathies	0.518	0.482	0.000
M45 Ankylosing spondylitis	0.518	0.482	0.000
I70-I79 Diseases of arteries, arterioles and capillaries	0.517	0.483	0.001
R07.4 Chest pain, unspecified	0.516	0.484	0.000
H55-H59 Other disorders of eye and adnexa	0.516	0.484	0.000
H53-H54 Visual disturbances and blindness	0.516	0.484	0.000
H46-H48 Disorders of optic nerve and visual pathways	0.516	0.484	0.000
H43-H45 Disorders of vitreous body and globe	0.516	0.484	0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body	0.516	0.484	0.000
H10-H13 Disorders of conjunctiva	0.516	0.484	0.000
I69 Sequelae of cerebrovascular disease	0.514	0.485	0.000
E70-E90 Metabolic disorders	0.513	0.487	0.000
C60-C63 Malignant neoplasms of male genital organs	0.510	0.490	0.000
R06 Abnormalities of breathing	0.509	0.491	0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.507	0.493	0.000
M35 Other systemic involvement of connective tissue	0.507	0.493	0.000
M34 Systemic sclerosis	0.507	0.493	0.000
M33 Dermatopolymyositis	0.507	0.493	0.000
M32 Systemic lupus erythematosus	0.507	0.493	0.000
M31 Other necrotising vasculopathies	0.507	0.493	0.000
M30 Polyarteritis nodosa and related conditions	0.507	0.493	0.000
M24 Other specific joint derangements	0.507	0.493	0.000
M21 Other acquired deformities of limbs	0.507	0.493	0.000
M25 Other joint disorders, not elsewhere classified	0.506	0.494	0.000
H25-H28 Disorders of lens	0.504	0.495	0.000
M19 Other arthrosis	0.504	0.496	0.000
E65-E68 Obesity and other hyperalimentation	0.503	0.497	0.000
M20 Acquired deformities of fingers and toes	0.502	0.497	0.000
O26 Maternal care for other conditions predominantly related to pregnancy	0.502	0.498	0.000
C68 Malignant neoplasm of other and unspecified urinary organs	0.501	0.499	0.000
C66 Malignant neoplasm of ureter	0.501	0.499	0.000
C65 Malignant neoplasm of renal pelvis	0.501	0.499	0.000
C64 Malignant neoplasm of kidney, except renal pelvis	0.501	0.499	0.000
J18.9 Pneumonia, unspecified	0.500	0.500	0.000
C50-C50 Malignant neoplasm of breast	0.499	0.501	0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use	0.499	0.501	0.000
R79 Other abnormal findings of blood chemistry	0.499	0.501	0.000
F03 Unspecified dementia	0.499	0.501	0.000
H80-H83 Diseases of inner ear	0.499	0.501	0.000
H60-H62 Diseases of external ear	0.499	0.501	0.000
R07.3 Other chest pain	0.499	0.501	0.000
N60-N64 Disorders of breast	0.498	0.502	0.000
N80-N98 Noninflammatory disorders of female genital tract	0.497	0.503	0.000
H90-H95 Other disorders of ear	0.496	0.504	0.000
R27 Other lack of coordination	0.496	0.504	0.000
R26 Abnormalities of gait and mobility	0.496	0.504	0.000
R25 Abnormal involuntary movements	0.496	0.504	0.000
O70 Perineal laceration during delivery	0.495	0.505	0.000
J17 Pneumonia in diseases classified elsewhere	0.495	0.505	0.000
J16 Pneumonia due to other infectious organisms, not elsewhere classified	0.495	0.505	0.000
J15 Bacterial pneumonia, not elsewhere classified	0.495	0.505	0.000
J12 Viral pneumonia, not elsewhere classified	0.495	0.505	0.000
J11 Influenza, virus not identified	0.495	0.505	0.000
J10 Influenza due to identified influenza virus	0.495	0.505	0.000
J14 Pneumonia due to Haemophilus influenzae	0.495	0.505	0.000
J13 Pneumonia due to Streptococcus pneumoniae	0.495	0.505	0.000
J09 Influenza due to certain identified influenza virus	0.495	0.505	0.000
M13.9 Arthritis, unspecified	0.494	0.506	0.000
M47.9 Spondylosis, unspecified	0.493	0.507	0.000
R30-R39 Symptoms and signs involving the urinary system	0.492	0.508	0.000
N17 Acute renal failure	0.492	0.508	0.000
I45 Other conduction disorders	0.490	0.510	0.000
R29.6 Tendency to fall, not elsewhere classified	0.489	0.511	0.000
M85 Other disorders of bone density and structure	0.486	0.514	0.000
M84 Disorders of continuity of bone	0.486	0.514	0.000
M83 Adult osteomalacia	0.486	0.514	0.000
M82 Osteoporosis in diseases classified elsewhere	0.486	0.514	0.000
M80 Osteoporosis with pathological fracture	0.486	0.514	0.000
G80-G83 Cerebral palsy and other paralytic syndromes	0.486	0.514	0.000
F41.9 Anxiety disorder, unspecified	0.486	0.514	0.000
I05-I09 Chronic rheumatic heart diseases	0.485	0.514	0.001
I00-I02 Acute rheumatic fever	0.485	0.514	0.001
O68 Labour and delivery complicated by foetal stress [distress]	0.483	0.517	0.000
C26 Malignant neoplasm of other and ill-defined digestive organs	0.481	0.519	0.000
C25 Malignant neoplasm of pancreas	0.481	0.519	0.000
C24 Malignant neoplasm of other and unspecified parts of biliary tract	0.481	0.519	0.000
C22 Malignant neoplasm of liver and intrahepatic bile ducts	0.481	0.519	0.000
C21 Malignant neoplasm of anus and anal canal	0.481	0.519	0.000
C17 Malignant neoplasm of small intestine	0.481	0.519	0.000
C16 Malignant neoplasm of stomach	0.481	0.519	0.000
C15 Malignant neoplasm of oesophagus	0.481	0.519	0.000
C23 Malignant neoplasm of gallbladder	0.481	0.519	0.000
C20 Malignant neoplasm of rectum	0.481	0.519	0.000
C19 Malignant neoplasm of rectosigmoid junction	0.481	0.519	0.000
E50-E64 Other nutritional deficiencies	0.480	0.520	0.000
E40-E46 Malnutrition	0.480	0.520	0.000
E20-E35 Disorders of other endocrine glands	0.480	0.520	0.000
J43 Emphysema	0.480	0.520	0.000
I64 Stroke, not specified as haemorrhage or infarction	0.478	0.522	0.000
M18 Arthrosis of first carpometacarpal joint	0.477	0.523	0.000
G40-G47 Episodic and paroxysmal disorders	0.476	0.523	0.000
J41 Simple and mucopurulent chronic bronchitis	0.476	0.524	0.000
J47 Bronchiectasis	0.476	0.524	0.000
J46 Status asthmaticus	0.476	0.524	0.000
J42 Unspecified chronic bronchitis	0.476	0.524	0.000
J40 Bronchitis, not specified as acute or chronic	0.476	0.524	0.000
J45 Asthma	0.475	0.525	0.000
I50 Heart failure	0.474	0.526	0.000
M47.8 Other spondylosis	0.472	0.528	0.000
J99 Respiratory disorders in diseases classified elsewhere	0.472	0.528	0.000
J96 Respiratory failure, not elsewhere classified	0.472	0.528	0.000
J95 Postprocedural respiratory disorders, not elsewhere classified	0.472	0.528	0.000
F41.2 Mixed anxiety and depressive disorder	0.472	0.528	0.000
L02 Cutaneous abscess, furuncle and carbuncle	0.470	0.529	0.000
C67.9 Bladder, unspecified	0.470	0.530	0.000
F48 Other neurotic disorders	0.469	0.531	0.000
F45 Somatoform disorders	0.469	0.531	0.000
F44 Dissociative [conversion] disorders	0.469	0.531	0.000
F43 Reaction to severe stress, and adjustment disorders	0.469	0.531	0.000
F42 Obsessive-compulsive disorder	0.469	0.531	0.000
F40 Phobic anxiety disorders	0.469	0.531	0.000
M22.4 Chondromalacia patellae	0.469	0.531	0.000
O63 Long labour	0.468	0.532	0.000
D25.2 Subserosal leiomyoma of uterus	0.468	0.532	0.000
D25.1 Intramural leiomyoma of uterus	0.468	0.532	0.000
B95-B98 Bacterial, viral and other infectious agents	0.468	0.532	0.000
D25.9 Leiomyoma of uterus, unspecified	0.467	0.532	0.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes	0.467	0.533	0.000
E00-E07 Disorders of thyroid gland	0.467	0.533	0.000
N99-N99 Other disorders of the genitourinary system	0.464	0.536	0.000
N25-N29 Other disorders of kidney and ureter	0.464	0.536	0.000
N10-N16 Renal tubulo-interstitial diseases	0.464	0.536	0.000
N00-N08 Glomerular diseases	0.464	0.536	0.000
G90-G99 Other disorders of the nervous system	0.464	0.536	0.000
G70-G73 Diseases of myoneural junction and muscle	0.464	0.536	0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system	0.464	0.536	0.000
G35-G37 Demyelinating diseases of the central nervous system	0.464	0.536	0.000
G30-G32 Other degenerative diseases of the nervous system	0.464	0.536	0.000
G20-G26 Extrapyramidal and movement disorders	0.464	0.536	0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system	0.464	0.536	0.000
G00-G09 Inflammatory diseases of the central nervous system	0.464	0.536	0.000
L57.0 Actinic keratosis	0.463	0.537	0.000
I68 Cerebrovascular disorders in diseases classified elsewhere	0.462	0.538	0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction	0.462	0.538	0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction	0.462	0.538	0.000
I62 Other nontraumatic intracranial haemorrhage	0.462	0.538	0.000
I61 Intracerebral haemorrhage	0.462	0.538	0.000
I60 Subarachnoid haemorrhage	0.462	0.538	0.000
M72.0 Palmar fascial fibromatosis [Dupuytren]	0.461	0.538	0.000
R07.2 Precordial pain	0.460	0.540	0.000
P90-P96 Other disorders originating in the perinatal period	0.458	0.542	0.000
P80-P83 Conditions involving the integument and temperature regulation of fetus and newborn	0.458	0.542	0.000
P75-P78 Digestive system disorders of fetus and newborn	0.458	0.542	0.000
P70-P74 Transitory endocrine and metabolic disorders specific to fetus and newborn	0.458	0.542	0.000
P50-P61 Haemorrhagic and haematological disorders of fetus and newborn	0.458	0.542	0.000
P35-P39 Infections specific to the perinatal period	0.458	0.542	0.000
P20-P29 Respiratory and cardiovascular disorders specific to the perinatal period	0.458	0.542	0.000
P10-P15 Birth trauma	0.458	0.542	0.000
P05-P08 Disorders related to length of gestation and fetal growth	0.458	0.542	0.000
P00-P04 Fetus and newborn affected by maternal factors and by complications of pregnancy, labour and delivery	0.458	0.542	0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.458	0.542	0.000
Q80-Q89 Other congenital malformations	0.458	0.542	0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.458	0.542	0.000
Q60-Q64 Congenital malformations of the urinary system	0.458	0.542	0.000
Q50-Q56 Congenital malformations of genital organs	0.458	0.542	0.000
Q38-Q45 Other congenital malformations of the digestive system	0.458	0.542	0.000
Q35-Q37 Cleft lip and cleft palate	0.458	0.542	0.000
Q30-Q34 Congenital malformations of the respiratory system	0.458	0.542	0.000
Q20-Q28 Congenital malformations of the circulatory system	0.458	0.542	0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.458	0.542	0.000
Q00-Q07 Congenital malformations of the nervous system	0.458	0.542	0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs	0.458	0.542	0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use	0.458	0.542	0.000
H71 Cholesteatoma of middle ear	0.458	0.542	0.000
A30-A49 Other bacterial diseases	0.457	0.542	0.000
D12.8 Rectum	0.455	0.545	0.000
M54 Dorsalgia	0.455	0.545	0.000
C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx	0.454	0.546	0.000
C13 Malignant neoplasm of hypopharynx	0.454	0.546	0.000
C11 Malignant neoplasm of nasopharynx	0.454	0.546	0.000
C10 Malignant neoplasm of oropharynx	0.454	0.546	0.000
C09 Malignant neoplasm of tonsil	0.454	0.546	0.000
C08 Malignant neoplasm of other and unspecified major salivary glands	0.454	0.546	0.000
C06 Malignant neoplasm of other and unspecified parts of mouth	0.454	0.546	0.000
C05 Malignant neoplasm of palate	0.454	0.546	0.000
C04 Malignant neoplasm of floor of mouth	0.454	0.546	0.000
C03 Malignant neoplasm of gum	0.454	0.546	0.000
C02 Malignant neoplasm of other and unspecified parts of tongue	0.454	0.546	0.000
C00 Malignant neoplasm of lip	0.454	0.546	0.000
C12 Malignant neoplasm of pyriform sinus	0.454	0.546	0.000
C07 Malignant neoplasm of parotid gland	0.454	0.546	0.000
C01 Malignant neoplasm of base of tongue	0.454	0.546	0.000
C42 hematopoietic and reticuloendothelial systems (ICD-O-3 specific)	0.454	0.546	0.000
C41 Malignant neoplasm of bone and articular cartilage of other and unspecified sites	0.454	0.546	0.000
C40 Malignant neoplasm of bone and articular cartilage of limbs	0.454	0.546	0.000
C49 Malignant neoplasm of other connective and soft tissue	0.454	0.546	0.000
C48 Malignant neoplasm of retroperitoneum and peritoneum	0.454	0.546	0.000
C47 Malignant neoplasm of peripheral nerves and autonomic nervous system	0.454	0.546	0.000
C46 Kaposi's sarcoma	0.454	0.546	0.000
C45 Mesothelioma	0.454	0.546	0.000
C57 Malignant neoplasm of other and unspecified female genital organs	0.454	0.546	0.000
C54 Malignant neoplasm of corpus uteri	0.454	0.546	0.000
C53 Malignant neoplasm of cervix uteri	0.454	0.546	0.000
C51 Malignant neoplasm of vulva	0.454	0.546	0.000
C58 Malignant neoplasm of placenta	0.454	0.546	0.000
C56 Malignant neoplasm of ovary	0.454	0.546	0.000
C55 Malignant neoplasm of uterus, part unspecified	0.454	0.546	0.000
C52 Malignant neoplasm of vagina	0.454	0.546	0.000
C72 Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system	0.454	0.546	0.000
C71 Malignant neoplasm of brain	0.454	0.546	0.000
C70 Malignant neoplasm of meninges	0.454	0.546	0.000
C69 Malignant neoplasm of eye and adnexa	0.454	0.546	0.000
C75 Malignant neoplasm of other endocrine glands and related structures	0.454	0.546	0.000
C74 Malignant neoplasm of adrenal gland	0.454	0.546	0.000
C73 Malignant neoplasm of thyroid gland	0.454	0.546	0.000
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue	0.454	0.546	0.000
C95 Leukaemia of unspecified cell type	0.454	0.546	0.000
C94 Other leukaemias of specified cell type	0.454	0.546	0.000
C93 Monocytic leukaemia	0.454	0.546	0.000
C92 Myeloid leukaemia	0.454	0.546	0.000
C91 Lymphoid leukaemia	0.454	0.546	0.000
C90 Multiple myeloma and malignant plasma cell neoplasms	0.454	0.546	0.000
C88 Malignant immunoproliferative diseases	0.454	0.546	0.000
C86 Other specified types of T/NK-cell lymphoma	0.454	0.546	0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma	0.454	0.546	0.000
C84 Peripheral and cutaneous T-cell lymphomas	0.454	0.546	0.000
C83 Diffuse non-Hodgkin's lymphoma	0.454	0.546	0.000
C82 Follicular [nodular] non-Hodgkin's lymphoma	0.454	0.546	0.000
C81 Hodgkin's disease	0.454	0.546	0.000
C97 Malignant neoplasms of independent (primary) multiple sites	0.454	0.546	0.000
D09 Carcinoma in situ of other and unspecified sites	0.454	0.546	0.000
D07 Carcinoma in situ of other and unspecified genital organs	0.454	0.546	0.000
D06 Carcinoma in situ of cervix uteri	0.454	0.546	0.000
D05 Carcinoma in situ of breast	0.454	0.546	0.000
D04 Carcinoma in situ of skin	0.454	0.546	0.000
D03 Melanoma in situ	0.454	0.546	0.000
D02 Carcinoma in situ of middle ear and respiratory system	0.454	0.546	0.000
D01 Carcinoma in situ of other and unspecified digestive organs	0.454	0.546	0.000
D00 Carcinoma in situ of oral cavity, oesophagus and stomach	0.454	0.546	0.000
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites	0.454	0.546	0.000
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue	0.454	0.546	0.000
D46 Myelodysplastic syndromes	0.454	0.546	0.000
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands	0.454	0.546	0.000
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system	0.454	0.546	0.000
D42 Neoplasm of uncertain or unknown behaviour of meninges	0.454	0.546	0.000
D41 Neoplasm of uncertain or unknown behaviour of urinary organs	0.454	0.546	0.000
D40 Neoplasm of uncertain or unknown behaviour of male genital organs	0.454	0.546	0.000
D39 Neoplasm of uncertain or unknown behaviour of female genital organs	0.454	0.546	0.000
D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs	0.454	0.546	0.000
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs	0.454	0.546	0.000
D45 Polycythaemia vera	0.454	0.546	0.000
I95-I99 Other and unspecified disorders of the circulatory system	0.454	0.546	0.001
O75 Other complications of labour and delivery, not elsewhere classified	0.454	0.546	0.000
O74 Complications of anaesthesia during labour and delivery	0.454	0.546	0.000
O73 Retained placenta and membranes, without haemorrhage	0.454	0.546	0.000
O72 Postpartum haemorrhage	0.454	0.546	0.000
O71 Other obstetric trauma	0.454	0.546	0.000
O69 Labour and delivery complicated by umbilical cord complications	0.454	0.546	0.000
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified	0.454	0.546	0.000
O66 Other obstructed labour	0.454	0.546	0.000
O65 Obstructed labour due to maternal pelvic abnormality	0.454	0.546	0.000
O64 Obstructed labour due to malposition and malpresentation of foetus	0.454	0.546	0.000
O62 Abnormalities of forces of labour	0.454	0.546	0.000
O61 Failed induction of labour	0.454	0.546	0.000
O60 Preterm delivery	0.454	0.546	0.000
R29.4 Clicking hip	0.452	0.548	0.000
R29.3 Abnormal posture	0.452	0.548	0.000
R29.2 Abnormal reflex	0.452	0.548	0.000
R29.1 Meningismus	0.452	0.548	0.000
R29.0 Tetany	0.452	0.548	0.000
R00.2 Palpitations	0.452	0.548	0.000
H02 Other disorders of eyelid	0.451	0.549	0.000
N70-N77 Inflammatory diseases of female pelvic organs	0.451	0.549	0.000
E87 Other disorders of fluid, electrolyte and acid-base balance	0.451	0.549	0.000
R07.1 Chest pain on breathing	0.450	0.549	0.000
R07.0 Pain in throat	0.450	0.549	0.000
M03 Postinfective and reactive arthropathies in diseases classified elsewhere	0.450	0.550	0.000
M02 Reactive arthropathies	0.450	0.550	0.000
M01 Direct infections of joint in infectious and parasitic diseases classified elsewhere	0.450	0.550	0.000
M00 Pyogenic arthritis	0.450	0.550	0.000
M43 Other deforming dorsopathies	0.450	0.550	0.000
M42 Spinal osteochondrosis	0.450	0.550	0.000
M41 Scoliosis	0.450	0.550	0.000
M40 Kyphosis and lordosis	0.450	0.550	0.000
M63 Disorders of muscle in diseases classified elsewhere	0.450	0.550	0.000
M62 Other disorders of muscle	0.450	0.550	0.000
M61 Calcification and ossification of muscle	0.450	0.550	0.000
M60 Myositis	0.450	0.550	0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere	0.450	0.550	0.000
M67 Other disorders of synovium and tendon	0.450	0.550	0.000
M66 Spontaneous rupture of synovium and tendon	0.450	0.550	0.000
M65 Synovitis and tenosynovitis	0.450	0.550	0.000
M90 Osteopathies in diseases classified elsewhere	0.450	0.550	0.000
M89 Other disorders of bone	0.450	0.550	0.000
M88 Paget's disease of bone [osteitis deformans]	0.450	0.550	0.000
M87 Osteonecrosis	0.450	0.550	0.000
M86 Osteomyelitis	0.450	0.550	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations