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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs74964132
log Bayes Factor = 8.1546
Chromosome 4   position 154,478,742  (GRCh37) Explore rs74964132 on Ensembl!
Variant rs74964132 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.999 0.001 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.997 0.003 0.000
M20-M25 Other joint disorders
0.985 0.015 0.000
Chapter XX External causes of morbidity and mortality
0.985 0.015 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.984 0.016 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.980 0.020 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.975 0.025 0.000
D50-D53 Nutritional anaemias
0.972 0.028 0.000
Chapter I Certain infectious and parasitic diseases
0.945 0.055 0.000
M25 Other joint disorders, not elsewhere classified
0.941 0.059 0.000
M70-M79 Other soft tissue disorders
0.933 0.067 0.000
Chapter VI Diseases of the nervous system
0.931 0.069 0.000
S00-S09 Injuries to the head
0.926 0.074 0.000
D50 Iron deficiency anaemia
0.925 0.075 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.915 0.085 0.000
M15-M19 Arthrosis
0.915 0.085 0.000
M23 Internal derangement of knee
0.912 0.088 0.000
Chapter XI Diseases of the digestive system
0.911 0.089 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.908 0.092 0.000
S80-S89 Injuries to the knee and lower leg
0.904 0.096 0.000
D51 Vitamin B12 deficiency anaemia
0.897 0.103 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.897 0.103 0.000
K20-K31 Diseases of oesophagus, stomach and duodenum
0.897 0.103 0.000
Chapter X Diseases of the respiratory system
0.895 0.105 0.000
Chapter V Mental and behavioural disorders
0.893 0.107 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.889 0.111 0.000
M25.5 Pain in joint
0.885 0.115 0.000
M22 Disorders of patella
0.881 0.119 0.000
M17 Gonarthrosis [arthrosis of knee]
0.877 0.123 0.000
M17.9 Gonarthrosis, unspecified
0.868 0.132 0.000
Chapter VII Diseases of the eye and adnexa
0.867 0.133 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.859 0.141 0.000
J30-J39 Other diseases of upper respiratory tract
0.859 0.141 0.000
K22 Other diseases of oesophagus
0.852 0.148 0.000
D50.8 Other iron deficiency anaemias
0.851 0.149 0.000
S09 Other and unspecified injuries of head
0.851 0.149 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.849 0.151 0.000
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.844 0.156 0.000
B95-B98 Bacterial, viral and other infectious agents
0.834 0.166 0.000
Y95 Nosocomial condition
0.834 0.166 0.000
Chapter XIV Diseases of the genitourinary system
0.832 0.168 0.000
J34 Other disorders of nose and nasal sinuses
0.830 0.170 0.000
Chapter IX Diseases of the circulatory system
0.824 0.176 0.000
Chapter VIII Diseases of the ear and mastoid process
0.822 0.178 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.816 0.184 0.000
M23.2 Derangement of meniscus due to old tear or injury
0.816 0.184 0.000
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts
0.811 0.189 0.000
O00-O08 Pregnancy with abortive outcome
0.811 0.189 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.807 0.193 0.000
D50.9 Iron deficiency anaemia, unspecified
0.806 0.194 0.000
K30 Dyspepsia
0.802 0.198 0.000
K22.7 Barrett's oesophagus
0.801 0.199 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.800 0.200 0.000
O20 Haemorrhage in early pregnancy
0.799 0.201 0.000
M50-M54 Other dorsopathies
0.799 0.201 0.000
B35-B49 Mycoses
0.798 0.202 0.000
O60-O75 Complications of labour and delivery
0.798 0.202 0.000
S09.9 Unspecified injury of head
0.797 0.203 0.000
Y83 Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.797 0.203 0.000
M75 Shoulder lesions
0.792 0.208 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.791 0.209 0.000
W00-W19 Falls
0.789 0.211 0.000
M23.8 Other internal derangements of knee
0.789 0.211 0.000
S60-S69 Injuries to the wrist and hand
0.787 0.213 0.000
O26 Maternal care for other conditions predominantly related to pregnancy
0.787 0.213 0.000
D52 Folate deficiency anaemia
0.787 0.213 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.782 0.218 0.000
G40-G47 Episodic and paroxysmal disorders
0.781 0.219 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.780 0.220 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.780 0.220 0.000
S70-S79 Injuries to the hip and thigh
0.778 0.222 0.000
O80-O84 Delivery
0.776 0.224 0.000
M25.55 Pain in joint (Pelvic region and thigh)
0.775 0.225 0.000
J34.8 Other specified disorders of nose and nasal sinuses
0.773 0.227 0.000
W20-W49 Exposure to inanimate mechanical forces
0.769 0.231 0.000
S80 Superficial injury of lower leg
0.768 0.232 0.000
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts
0.765 0.235 0.000
M91-M94 Chondropathies
0.764 0.236 0.000
I60-I69 Cerebrovascular diseases
0.764 0.236 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.759 0.241 0.000
M25.4 Effusion of joint
0.754 0.246 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.753 0.246 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
0.752 0.248 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.749 0.251 0.000
A00-A09 Intestinal infectious diseases
0.748 0.252 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.746 0.253 0.000
K65-K67 Diseases of peritoneum
0.746 0.254 0.000
G90-G99 Other disorders of the nervous system
0.745 0.255 0.000
M22.4 Chondromalacia patellae
0.745 0.255 0.000
J00-J06 Acute upper respiratory infections
0.745 0.255 0.000
M22.2 Patellofemoral disorders
0.744 0.255 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.744 0.256 0.000
S82 Fracture of lower leg, including ankle
0.743 0.257 0.000
N40-N51 Diseases of male genital organs
0.742 0.258 0.000
T84.1 Mechanical complication of internal fixation device of bones of limb
0.741 0.259 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.741 0.259 0.000
M72 Fibroblastic disorders
0.739 0.261 0.000
M23.22 Derangement of meniscus due to old tear or injury (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.737 0.263 0.000
K22.4 Dyskinesia of oesophagus
0.736 0.264 0.000
M25.56 Pain in joint (Lower leg)
0.734 0.266 0.000
K20 Oesophagitis
0.733 0.267 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.733 0.267 0.000
N60-N64 Disorders of breast
0.733 0.267 0.000
M80-M85 Disorders of bone density and structure
0.732 0.268 0.000
G30-G32 Other degenerative diseases of the nervous system
0.730 0.269 0.000
M75.4 Impingement syndrome of shoulder
0.730 0.270 0.000
M25.7 Osteophyte
0.730 0.270 0.000
T84.6 Infection and inflammatory reaction due to internal fixation device [any site]
0.729 0.271 0.000
M25.53 Pain in joint (Forearm)
0.727 0.273 0.000
J60-J70 Lung diseases due to external agents
0.726 0.274 0.000
T85.8 Other complications of internal prosthetic devices, implants and grafts, not elsewhere classified
0.725 0.275 0.000
S20-S29 Injuries to the thorax
0.725 0.275 0.000
K31 Other diseases of stomach and duodenum
0.723 0.276 0.000
M77 Other enthesopathies
0.722 0.277 0.000
O20.0 Threatened abortion
0.722 0.278 0.000
K00-K14 Diseases of oral cavity, salivary glands and jaws
0.720 0.280 0.000
Chapter XXII Codes for special purposes
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.716 0.284 0.000
M86-M90 Other osteopathies
0.716 0.284 0.000
M60-M63 Disorders of muscles
0.716 0.284 0.000
M00-M03 Infectious arthropathies
0.716 0.284 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.716 0.284 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.715 0.285 0.000
T79-T79 Certain early complications of trauma
0.715 0.285 0.000
T66-T78 Other and unspecified effects of external causes
0.715 0.285 0.000
T33-T35 Frostbite
0.715 0.285 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.715 0.285 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.715 0.285 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.715 0.285 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.715 0.285 0.000
T00-T07 Injuries involving multiple body regions
0.715 0.285 0.000
S90-S99 Injuries to the ankle and foot
0.715 0.285 0.000
S10-S19 Injuries to the neck
0.715 0.285 0.000
J34.2 Deviated nasal septum
0.715 0.285 0.000
M25.57 Pain in joint (Ankle and foot)
0.713 0.287 0.000
S00 Superficial injury of head
0.711 0.289 0.000
D60-D64 Aplastic and other anaemias
0.710 0.290 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.710 0.290 0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters
0.709 0.291 0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems
0.709 0.291 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.706 0.293 0.000
M34 Systemic sclerosis
0.706 0.293 0.000
M33 Dermatopolymyositis
0.706 0.293 0.000
M32 Systemic lupus erythematosus
0.706 0.293 0.000
M31 Other necrotising vasculopathies
0.706 0.293 0.000
M30 Polyarteritis nodosa and related conditions
0.706 0.293 0.000
M21 Other acquired deformities of limbs
0.706 0.293 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.706 0.293 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.706 0.293 0.000
Y35-Y36 Legal intervention and operations of war
0.706 0.293 0.000
Y10-Y34 Event of undetermined intent
0.706 0.293 0.000
Y00-Y09 Assault
0.706 0.293 0.000
X85-X99 Assault
0.706 0.293 0.000
X60-X84 Intentional self-harm
0.706 0.293 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.706 0.293 0.000
X50-X57 Overexertion, travel and privation
0.706 0.293 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.706 0.293 0.000
X30-X39 Exposure to forces of nature
0.706 0.293 0.000
X20-X29 Contact with venomous animals and plants
0.706 0.293 0.000
X10-X19 Contact with heat and hot substances
0.706 0.293 0.000
X00-X09 Exposure to smoke, fire and flames
0.706 0.293 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.706 0.293 0.000
W75-W84 Other accidental threats to breathing
0.706 0.293 0.000
W65-W74 Accidental drowning and submersion
0.706 0.293 0.000
W50-W64 Exposure to animate mechanical forces
0.706 0.293 0.000
V98-V99 Other and unspecified transport accidents
0.706 0.293 0.000
V95-V97 Air and space transport accidents
0.706 0.293 0.000
V90-V94 Water transport accidents
0.706 0.293 0.000
V80-V89 Other land transport accidents
0.706 0.293 0.000
V70-V79 Bus occupant injured in transport accident
0.706 0.293 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.706 0.293 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.706 0.293 0.000
V40-V49 Car occupant injured in transport accident
0.706 0.293 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.706 0.293 0.000
V20-V29 Motorcycle rider injured in transport accident
0.706 0.293 0.000
V10-V19 Pedal cyclist injured in transport accident
0.706 0.293 0.000
V01-V09 Pedestrian injured in transport accident
0.706 0.293 0.000
S40-S49 Injuries to the shoulder and upper arm
0.706 0.294 0.000
D80-D89 Certain disorders involving the immune mechanism
0.706 0.294 0.000
D55-D59 Haemolytic anaemias
0.706 0.294 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.706 0.294 0.000
H04 Disorders of lachrymal system
0.706 0.294 0.000
M19 Other arthrosis
0.705 0.295 0.000
S01 Open wound of head
0.704 0.296 0.000
S81 Open wound of lower leg
0.704 0.296 0.000
K22.9 Disease of oesophagus, unspecified
0.703 0.297 0.000
O85-O92 Complications predominantly related to the puerperium
0.702 0.298 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.702 0.298 0.000
B25-B34 Other viral diseases
0.700 0.299 0.000
O26.8 Other specified pregnancy-related conditions
0.700 0.300 0.000
M65-M68 Disorders of synovium and tendon
0.700 0.300 0.000
Y84 Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.699 0.301 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.699 0.301 0.000
T87 Complications peculiar to reattachment and amputation
0.699 0.301 0.000
T86 Failure and rejection of transplanted organs and tissues
0.699 0.301 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.699 0.301 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.699 0.301 0.000
D53 Other nutritional anaemias
0.697 0.303 0.000
T84.0 Mechanical complication of internal joint prosthesis
0.694 0.306 0.000
M40-M43 Deforming dorsopathies
0.694 0.306 0.000
H43-H45 Disorders of vitreous body and globe
0.694 0.306 0.000
O75 Other complications of labour and delivery, not elsewhere classified
0.693 0.307 0.000
B37 Candidiasis
0.692 0.308 0.000
A30-A49 Other bacterial diseases
0.692 0.308 0.000
T85.5 Mechanical complication of gastro-intestinal prosthetic devices, implants and grafts
0.690 0.310 0.000
K70-K77 Diseases of liver
0.690 0.310 0.000
R07 Pain in throat and chest
0.689 0.311 0.000
S50-S59 Injuries to the elbow and forearm
0.685 0.315 0.000
M24 Other specific joint derangements
0.685 0.315 0.000
M79.6 Pain in limb
0.682 0.318 0.000
O03 Spontaneous abortion
0.682 0.318 0.000
K22.8 Other specified diseases of oesophagus
0.682 0.318 0.000
Y86 Sequelae of other accidents
0.679 0.321 0.000
B96 Other bacterial agents as the cause of diseases classified to other chapters
0.678 0.322 0.000
B99-B99 Other infectious diseases
0.678 0.322 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.678 0.322 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.678 0.322 0.000
B65-B83 Helminthiases
0.678 0.322 0.000
B50-B64 Protozoal diseases
0.678 0.322 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.678 0.322 0.000
B15-B19 Viral hepatitis
0.678 0.322 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.678 0.322 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.678 0.322 0.000
A80-A89 Viral infections of the central nervous system
0.678 0.322 0.000
A75-A79 Rickettsioses
0.678 0.322 0.000
A70-A74 Other diseases caused by chlamydiae
0.678 0.322 0.000
A65-A69 Other spirochaetal diseases
0.678 0.322 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.678 0.322 0.000
A20-A28 Certain zoonotic bacterial diseases
0.678 0.322 0.000
A15-A19 Tuberculosis
0.678 0.322 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.676 0.324 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.675 0.325 0.000
M25.9 Joint disorder, unspecified
0.675 0.325 0.000
M25.8 Other specified joint disorders
0.675 0.325 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.675 0.325 0.000
M25.3 Other instability of joint
0.675 0.325 0.000
M25.2 Flail joint
0.675 0.325 0.000
M25.1 Fistula of joint
0.675 0.325 0.000
M25.0 Haemarthrosis
0.675 0.325 0.000
M23.81 Other internal derangements of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.672 0.328 0.000
K26 Duodenal ulcer
0.671 0.329 0.000
S80.9 Superficial injury of lower leg, unspecified
0.671 0.329 0.000
S02 Fracture of skull and facial bones
0.669 0.331 0.000
M76 Enthesopathies of lower limb, excluding foot
0.669 0.331 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.669 0.331 0.000
M71 Other bursopathies
0.669 0.331 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.669 0.331 0.000
D68 Other coagulation defects
0.669 0.331 0.000
H53-H54 Visual disturbances and blindness
0.668 0.332 0.000
G70-G73 Diseases of myoneural junction and muscle
0.668 0.332 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.668 0.332 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.668 0.332 0.000
N25-N29 Other disorders of kidney and ureter
0.666 0.334 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.664 0.336 0.000
S08 Traumatic amputation of part of head
0.664 0.336 0.000
S07 Crushing injury of head
0.664 0.336 0.000
S06 Intracranial injury
0.664 0.336 0.000
S05 Injury of eye and orbit
0.664 0.336 0.000
S04 Injury of cranial nerves
0.664 0.336 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.664 0.336 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.664 0.336 0.000
D50.1 Sideropenic dysphagia
0.663 0.337 0.000
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.663 0.337 0.000
J35 Chronic diseases of tonsils and adenoids
0.662 0.338 0.000
H10-H13 Disorders of conjunctiva
0.660 0.340 0.000
Y83.2 Surgical operation with anastomosis, bypass or graft
0.660 0.340 0.000
G40 Epilepsy
0.660 0.340 0.000
G43 Migraine
0.659 0.341 0.000
J34.3 Hypertrophy of nasal turbinates
0.657 0.343 0.000
N60 Benign mammary dysplasia
0.657 0.343 0.000
T84.9 Unspecified complication of internal orthopaedic prosthetic device, implant and graft
0.656 0.344 0.000
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts
0.656 0.344 0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis
0.656 0.344 0.000
T84.4 Mechanical complication of other internal orthopaedic devices, imnplants and grafts
0.656 0.344 0.000
T84.3 Mechanical complication of other bone devices, implants and grafts
0.656 0.344 0.000
T84.2 Mechanical complication of internal fixation device of other bones
0.656 0.344 0.000
M15 Polyarthrosis
0.656 0.344 0.000
M50 Cervical disk disorders
0.656 0.344 0.000
R07.2 Precordial pain
0.656 0.344 0.000
H60-H62 Diseases of external ear
0.655 0.344 0.000
M23.9 Internal derangement of knee, unspecified
0.654 0.346 0.000
M23.6 Other spontaneous disruption of ligament(s) of knee
0.654 0.346 0.000
M23.5 Chronic instability of knee
0.654 0.346 0.000
M23.4 Loose body in knee
0.654 0.346 0.000
M23.1 Discoid meniscus (congenital)
0.654 0.346 0.000
M23.0 Cystic meniscus
0.654 0.346 0.000
D52.9 Folate deficiency anaemia, unspecified
0.654 0.346 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.653 0.346 0.000
O29 Complications of anaesthesia during pregnancy
0.651 0.349 0.000
O28 Abnormal findings on antenatal screening of mother
0.651 0.349 0.000
O24 Diabetes mellitus in pregnancy
0.651 0.349 0.000
O23 Infections of genito-urinary tract in pregnancy
0.651 0.349 0.000
O22 Venous complications in pregnancy
0.651 0.349 0.000
O21 Excessive vomiting in pregnancy
0.651 0.349 0.000
O25 Malnutrition in pregnancy
0.651 0.349 0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.650 0.350 0.000
K90-K93 Other diseases of the digestive system
0.648 0.352 0.000
S89 Other and unspecified injuries of lower leg
0.648 0.352 0.000
S88 Traumatic amputation of lower leg
0.648 0.352 0.000
S87 Crushing injury of lower leg
0.648 0.352 0.000
S86 Injury of muscle and tendon at lower leg level
0.648 0.352 0.000
S85 Injury of blood vessels at lower leg level
0.648 0.352 0.000
S84 Injury of nerves at lower leg level
0.648 0.352 0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee
0.648 0.352 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.647 0.353 0.000
L50-L54 Urticaria and erythema
0.646 0.354 0.000
K25 Gastric ulcer
0.646 0.354 0.000
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts
0.646 0.354 0.000
M23.21 Derangement of meniscus due to old tear or injury (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.645 0.355 0.000
M23.24 Derangement of meniscus due to old tear or injury (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.644 0.356 0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.643 0.356 0.000
D51.8 Other vitamin B12 deficiency anaemias
0.643 0.356 0.000
D51.3 Other dietary vitamin B12 deficiency anaemia
0.643 0.356 0.000
D51.2 Transcobalamin II deficiency
0.643 0.356 0.000
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.643 0.356 0.000
Y91 Evidence of alcohol involvement determined by level of intoxication
0.643 0.357 0.000
Y90 Evidence of alcohol involvement determined by blood alcohol level
0.643 0.357 0.000
Y98 Lifestyle-related condition
0.643 0.357 0.000
Y97 Environmental-pollution-related condition
0.643 0.357 0.000
Y96 Work-related condition
0.643 0.357 0.000
K28 Gastrojejunal ulcer
0.643 0.357 0.000
K27 Peptic ulcer, site unspecified
0.643 0.357 0.000
K23 Disorders of oesophagus in diseases classified elsewhere
0.643 0.357 0.000
J38 Diseases of vocal cords and larynx, not elsewhere classified
0.643 0.357 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.642 0.358 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.641 0.359 0.000
J95-J99 Other diseases of the respiratory system
0.641 0.359 0.000
F99-F99 Unspecified mental disorder
0.640 0.360 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.640 0.360 0.000
F80-F89 Disorders of psychological development
0.640 0.360 0.000
F70-F79 Mental retardation
0.640 0.360 0.000
F60-F69 Disorders of adult personality and behaviour
0.640 0.360 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.640 0.360 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.640 0.360 0.000
M25.76 Osteophyte (Lower leg)
0.640 0.360 0.000
M05-M14 Inflammatory polyarthropathies
0.639 0.361 0.000
R47-R49 Symptoms and signs involving speech and voice
0.639 0.361 0.000
Y83.4 Other reconstructive surgery
0.639 0.361 0.000
L98 Other disorders of skin and subcutaneous tissue, not elsewhere classified
0.638 0.362 0.000
G55 Nerve root and plexus compressions in diseases classified elsewhere
0.637 0.363 0.000
N30-N39 Other diseases of urinary system
0.637 0.363 0.000
M79.66 Pain in limb (Lower leg)
0.637 0.363 0.000
H65-H75 Diseases of middle ear and mastoid
0.636 0.364 0.000
M25.59 Pain in joint (Site unspecified)
0.634 0.366 0.000
M25.58 Pain in joint (Other)
0.634 0.366 0.000
M25.54 Pain in joint (Hand)
0.634 0.366 0.000
M25.52 Pain in joint (Upper arm)
0.634 0.366 0.000
M25.50 Pain in joint (Multiple sites)
0.634 0.366 0.000
F41 Other anxiety disorders
0.632 0.368 0.000
M22.1 Recurrent subluxation of patella
0.632 0.368 0.000
M22.9 Disorder of patella, unspecified
0.632 0.368 0.000
M22.8 Other disorders of patella
0.632 0.368 0.000
M22.3 Other derangements of patella
0.632 0.368 0.000
M22.0 Recurrent dislocation of patella
0.632 0.368 0.000
N10-N16 Renal tubulo-interstitial diseases
0.632 0.368 0.000
W10 Fall on and from stairs and steps
0.631 0.369 0.000
O16 Unspecified maternal hypertension
0.630 0.370 0.000
M17.5 Other secondary gonarthrosis
0.629 0.371 0.000
M17.4 Other secondary gonarthrosis, bilateral
0.629 0.371 0.000
M17.3 Other posttraumatic gonarthrosis
0.629 0.371 0.000
M17.2 Posttraumatic gonarthrosis, bilateral
0.629 0.371 0.000
I69 Sequelae of cerebrovascular disease
0.629 0.371 0.000
F00 Dementia in Alzheimer's disease
0.628 0.372 0.000
D69 Purpura and other haemorrhagic conditions
0.628 0.372 0.000
H01 Other inflammation of eyelid
0.627 0.372 0.000
Y83.3 Surgical operation with formation of external stoma
0.627 0.373 0.000
L97 Ulcer of lower limb, not elsewhere classified
0.625 0.375 0.000
K13 Other diseases of lip and oral mucosa
0.625 0.375 0.000
K29 Gastritis and duodenitis
0.625 0.375 0.000
F03 Unspecified dementia
0.625 0.375 0.000
M45-M49 Spondylopathies
0.624 0.376 0.000
J30 Vasomotor and allergic rhinitis
0.623 0.377 0.000
R06 Abnormalities of breathing
0.623 0.377 0.000
N62 Hypertrophy of breast
0.622 0.378 0.000
M23.89 Other internal derangements of knee (Unspecified ligament or Unspecified meniscus)
0.622 0.378 0.000
H55-H59 Other disorders of eye and adnexa
0.621 0.378 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.621 0.378 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.621 0.378 0.000
S72 Fracture of femur
0.621 0.378 0.000
M75.5 Bursitis of shoulder
0.621 0.379 0.000
Y83.9 Surgical procedure, unspecified
0.620 0.380 0.000
M54 Dorsalgia
0.620 0.380 0.000
M25.46 Effusion of joint (Lower leg)
0.619 0.381 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.618 0.382 0.000
S66 Injury of muscle and tendon at wrist and hand level
0.616 0.384 0.000
T82.9 Unspecified complication of cardiac and vascular prosthetic device, implant and graft
0.616 0.384 0.000
T82.6 Infection and inflammatory reaction due to cardiac valve prosthesis
0.616 0.384 0.000
T82.5 Mechanical complication of other cardiac and vascular devices and implants
0.616 0.384 0.000
T82.4 Mechanical complication of vascular dialysis catheter
0.616 0.384 0.000
T82.3 Mechanical complication of other vascular grafts
0.616 0.384 0.000
T82.2 Mechanical complication of coronary artery bypass and valve grafts
0.616 0.384 0.000
T82.1 Mechanical complication of cardiac electronic device
0.616 0.384 0.000
T82.0 Mechanical complication of heart valve prosthesis
0.616 0.384 0.000
M23.3 Other meniscus derangements
0.616 0.384 0.000
K65 Peritonitis
0.616 0.384 0.000
J37 Chronic laryngitis and laryngotracheitis
0.616 0.384 0.000
J36 Peritonsillar abscess
0.616 0.384 0.000
I60 Subarachnoid haemorrhage
0.615 0.385 0.000
N40 Hyperplasia of prostate
0.614 0.386 0.000
J33 Nasal polyp
0.613 0.387 0.000
F06 Other mental disorders due to brain damage and dysfunction and to physical disease
0.613 0.387 0.000
O68 Labour and delivery complicated by foetal stress [distress]
0.612 0.388 0.000
O80 Single spontaneous delivery
0.611 0.389 0.000
K22.6 Gastro-oesophageal laceration-haemorrhage syndrome
0.611 0.389 0.000
K22.5 Diverticulum of oesophagus, acquired
0.611 0.389 0.000
K22.3 Perforation of oesophagus
0.611 0.389 0.000
K22.0 Achalasia of cardia
0.611 0.389 0.000
S09.8 Other specified injuries of head
0.610 0.390 0.000
S09.7 Multiple injuries of head
0.610 0.390 0.000
S09.2 Traumatic rupture of ear drum
0.610 0.390 0.000
S09.1 Injury of muscle and tendon of head
0.610 0.390 0.000
S09.0 Injury of blood vessels of head, not elsewhere classified
0.610 0.390 0.000
Chapter II Neoplasms
0.609 0.391 0.000
L91 Hypertrophic disorders of skin
0.609 0.391 0.000
T85.9 Unspecified complication of internal prosthetic device, implant and graft
0.609 0.391 0.000
T85.6 Mechanical complication of other specified internal prosthetic devices, implants and grafts
0.609 0.391 0.000
T85.4 Mechanical complication of breast prosthesis and implant
0.609 0.391 0.000
T85.3 Mechanical complication of other ocular prosthetic devices, imnplants and grafts
0.609 0.391 0.000
T85.2 Mechanical complication of intraocular lens
0.609 0.391 0.000
T85.1 Mechanical complication of implanted electronic stimulator of nervous system
0.609 0.391 0.000
T85.0 Mechanical complication of ventricular intracranial (communicating) shunt
0.609 0.391 0.000
H04.5 Stenosis and insufficiency of lachrymal passages
0.608 0.392 0.000
B98 Other specified infectious agents as the cause of diseases classified to other chapters
0.607 0.392 0.000
G20-G26 Extrapyramidal and movement disorders
0.607 0.393 0.000
Y83.1 Surgical operation with implant of artificial internal device
0.607 0.393 0.000
L85 Other epidermal thickening
0.605 0.395 0.000
J69 Pneumonitis due to solids and liquids
0.604 0.395 0.000
K35-K38 Diseases of appendix
0.604 0.395 0.000
M18 Arthrosis of first carpometacarpal joint
0.602 0.398 0.000
O13 Gestational [pregnancy-induced] hypertension without significant proteinuria
0.602 0.398 0.000
I64 Stroke, not specified as haemorrhage or infarction
0.601 0.399 0.000
I05-I09 Chronic rheumatic heart diseases
0.601 0.399 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.601 0.399 0.000
H90-H95 Other disorders of ear
0.600 0.400 0.000
G44 Other headache syndromes
0.600 0.400 0.000
M72.0 Palmar fascial fibromatosis [Dupuytren]
0.600 0.400 0.000
J39 Other diseases of upper respiratory tract
0.599 0.401 0.000
J00 Acute nasopharyngitis [common cold]
0.599 0.401 0.000
B97 Viral agents as the cause of diseases classified to other chapters
0.598 0.402 0.000
J31 Chronic rhinitis, nasopharyngitis and pharyngitis
0.597 0.403 0.000
O02 Other abnormal products of conception
0.597 0.403 0.000
J09-J18 Influenza and pneumonia
0.596 0.403 0.000
M94 Other disorders of cartilage
0.596 0.404 0.000
L84 Corns and callosities
0.596 0.404 0.000
B96.5 Pseudomonas (aeruginosa)(mallei)(pseudomallei) as the cause of diseases classified to other chapters
0.595 0.405 0.000
J34.1 Cyst and mucocele of nose and nasal sinus
0.595 0.405 0.000
J34.0 Abscess, furuncle and carbuncle of nose
0.595 0.405 0.000
N50 Other disorders of male genital organs
0.595 0.405 0.000
W25 Contact with sharp glass
0.594 0.405 0.000
S82.1 Fracture of upper end of tibia
0.594 0.406 0.000
I80 Phlebitis and thrombophlebitis
0.594 0.406 0.000
G51 Facial nerve disorders
0.593 0.407 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.593 0.407 0.000
M23.20 Derangement of meniscus due to old tear or injury (Multiple sites)
0.592 0.408 0.000
O63 Long labour
0.592 0.408 0.000
K40-K46 Hernia
0.592 0.408 0.000
L90 Atrophic disorders of skin
0.592 0.408 0.000
W19 Unspecified fall
0.591 0.409 0.000
I00-I02 Acute rheumatic fever
0.591 0.409 0.000
M20 Acquired deformities of fingers and toes
0.590 0.410 0.000
H80-H83 Diseases of inner ear
0.589 0.411 0.000
M35 Other systemic involvement of connective tissue
0.588 0.411 0.000
S82.4 Fracture of fibula alone
0.589 0.411 0.000
N45 Orchitis and epididymitis
0.588 0.412 0.000
R07.3 Other chest pain
0.587 0.413 0.000
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
0.586 0.414 0.000
D67 Hereditary factor IX deficiency
0.585 0.414 0.000
D66 Hereditary factor VIII deficiency
0.585 0.414 0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.585 0.414 0.000
J32 Chronic sinusitis
0.585 0.415 0.000
M23.29 Derangement of meniscus due to old tear or injury (Unspecified ligament or Unspecified meniscus)
0.585 0.415 0.000
M23.27 Derangement of meniscus due to old tear or injury-Capsular
0.585 0.415 0.000
M23.25 Derangement of meniscus due to old tear or injury (Posterior horn of lateral meniscus)
0.585 0.415 0.000
F43 Reaction to severe stress, and adjustment disorders
0.584 0.416 0.000
H52 Disorders of refraction and accommodation
0.583 0.417 0.000
S61 Open wound of wrist and hand
0.583 0.417 0.000
O08 Complications following abortion and ectopic and molar pregnancy
0.581 0.418 0.000
O07 Failed attempted abortion
0.581 0.418 0.000
O06 Unspecified abortion
0.581 0.418 0.000
O05 Other abortion
0.581 0.418 0.000
O01 Hydatidiform mole
0.581 0.418 0.000
O00 Ectopic pregnancy
0.581 0.418 0.000
O82 Single delivery by Caesarean section
0.581 0.419 0.000
G93 Other disorders of brain
0.581 0.419 0.000
O75.7 Vaginal delivery following previous Caesarean section
0.580 0.420 0.000
O04 Medical abortion
0.580 0.420 0.000
A09 Diarrhoea and gastro-enteritis of presumed infectious origin
0.580 0.420 0.000
M79.7 Fibromyalgia
0.579 0.421 0.000
N99-N99 Other disorders of the genitourinary system
0.579 0.421 0.000
K31.7 Polyp of stomach and duodenum
0.579 0.421 0.000
Y89 Sequelae of other external causes
0.579 0.421 0.000
Y88 Sequelae of surgical and medical care as external cause
0.579 0.421 0.000
Y87 Sequelae of intentional self-harm, assault and events of undetermined intent
0.579 0.421 0.000
Y85 Sequelae of transport accidents
0.579 0.421 0.000
T81 Complications of procedures, not elsewhere classified
0.578 0.422 0.000
Y84.2 Radiological procedure and radiotherapy
0.578 0.422 0.000
W22 Striking against or struck by other objects
0.577 0.423 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.577 0.423 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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