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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs75083968
log Bayes Factor = 11.2858
Chromosome 4   position 96,127,609  (GRCh37) Explore rs75083968 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
R10-R19 Symptoms and signs involving the digestive system and abdomen
1.000 0.000 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
1.000 0.000 0.000
E10-E14 Diabetes mellitus
1.000 0.000 0.000
R10 Abdominal and pelvic pain
0.998 0.002 0.000
E11 Non-insulin-dependent diabetes mellitus
0.998 0.002 0.000
R11 Nausea and vomiting
0.996 0.004 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.993 0.007 0.000
R10.4 Other and unspecified abdominal pain
0.992 0.008 0.000
E10 Insulin-dependent diabetes mellitus
0.990 0.010 0.000
Chapter XX External causes of morbidity and mortality
0.981 0.019 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.975 0.025 0.000
R14 Flatulence and related conditions
0.969 0.031 0.000
E70-E90 Metabolic disorders
0.966 0.034 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.960 0.040 0.000
Chapter VI Diseases of the nervous system
0.956 0.044 0.000
E10.9 Without complications
0.943 0.057 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.939 0.061 0.000
R10.3 Pain localised to other parts of lower abdomen
0.935 0.065 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.932 0.068 0.000
E11.9 Without complications
0.932 0.068 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.929 0.071 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.924 0.076 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.922 0.078 0.000
E14 Unspecified diabetes mellitus
0.920 0.080 0.000
Chapter V Mental and behavioural disorders
0.918 0.082 0.000
R50-R69 General symptoms and signs
0.915 0.085 0.000
E65-E68 Obesity and other hyperalimentation
0.910 0.090 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.899 0.101 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.898 0.102 0.000
E11.4 With neurological complications
0.894 0.106 0.000
M20-M25 Other joint disorders
0.893 0.107 0.000
R53 Malaise and fatigue
0.890 0.110 0.000
R18 Ascites
0.889 0.111 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.888 0.112 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.885 0.115 0.000
R10.0 Acute abdomen
0.884 0.116 0.000
E11.3 With ophthalmic complications
0.881 0.119 0.000
Chapter IX Diseases of the circulatory system
0.880 0.120 0.000
E11.1 With ketoacidosis
0.879 0.121 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.876 0.124 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.876 0.124 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.874 0.126 0.000
I60-I69 Cerebrovascular diseases
0.870 0.130 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.868 0.132 0.000
G57 Mononeuropathies of lower limb
0.865 0.135 0.000
E14.9 Without complications
0.864 0.136 0.000
R52 Pain, not elsewhere classified
0.863 0.137 0.000
S60-S69 Injuries to the wrist and hand
0.849 0.151 0.000
E11.2 With renal complications
0.848 0.152 0.000
Y42.8 Other and unspecified hormones and their synthetic substitutes
0.848 0.152 0.000
R30-R39 Symptoms and signs involving the urinary system
0.847 0.153 0.000
E10.2 With renal complications
0.847 0.153 0.000
E66 Obesity
0.846 0.154 0.000
F40 Phobic anxiety disorders
0.844 0.156 0.000
E20-E35 Disorders of other endocrine glands
0.844 0.156 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.843 0.157 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.841 0.159 0.000
S20-S29 Injuries to the thorax
0.837 0.163 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.836 0.164 0.000
G59 Mononeuropathy in diseases classified elsewhere
0.832 0.168 0.000
E87.1 Hypo-osmolality and hyponatraemia
0.830 0.170 0.000
R39 Other symptoms and signs involving the urinary system
0.827 0.173 0.000
I67 Other cerebrovascular diseases
0.816 0.184 0.000
E66.8 Other obesity
0.815 0.185 0.000
R41 Other symptoms and signs involving cognitive functions and awareness
0.815 0.185 0.000
E87.7 Fluid overload
0.813 0.187 0.000
R39.8 Other and unspecified symptoms and signs involving the urinary system
0.813 0.187 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.811 0.189 0.000
Y43 Primarily systemic agents
0.808 0.192 0.000
E50-E64 Other nutritional deficiencies
0.806 0.194 0.000
E10.3 With ophthalmic complications
0.806 0.194 0.000
Chapter I Certain infectious and parasitic diseases
0.805 0.195 0.000
E10.4 With neurological complications
0.803 0.197 0.000
E40-E46 Malnutrition
0.803 0.197 0.000
R63 Symptoms and signs concerning food and fluid intake
0.803 0.197 0.000
M40-M43 Deforming dorsopathies
0.803 0.197 0.000
E16 Other disorders of pancreatic internal secretion
0.802 0.198 0.000
T51 Toxic effect of alcohol
0.798 0.202 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.798 0.202 0.000
E11.5 With peripheral circulatory complications
0.794 0.206 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.792 0.208 0.000
R17 Unspecified jaundice
0.792 0.208 0.000
R42 Dizziness and giddiness
0.791 0.209 0.000
I67.9 Cerebrovascular disease, unspecified
0.791 0.209 0.000
I69 Sequelae of cerebrovascular disease
0.787 0.213 0.000
R45 Symptoms and signs involving emotional state
0.787 0.213 0.000
M91-M94 Chondropathies
0.786 0.214 0.000
X60-X84 Intentional self-harm
0.785 0.215 0.000
R16 Hepatomegaly and splenomegaly, not elsewhere classified
0.779 0.221 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.778 0.222 0.000
E86 Volume depletion
0.778 0.222 0.000
F40.2 Specific (isolated) phobias
0.777 0.223 0.000
F43 Reaction to severe stress, and adjustment disorders
0.775 0.225 0.000
G55 Nerve root and plexus compressions in diseases classified elsewhere
0.772 0.228 0.000
E87.6 Hypokalaemia
0.771 0.229 0.000
R26 Abnormalities of gait and mobility
0.771 0.229 0.000
F41 Other anxiety disorders
0.771 0.229 0.000
Y52 Agents primarily affecting the cardiovascular system
0.770 0.230 0.000
I64 Stroke, not specified as haemorrhage or infarction
0.769 0.231 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.769 0.231 0.000
E10.5 With peripheral circulatory complications
0.769 0.231 0.000
R10.2 Pelvic and perineal pain
0.767 0.233 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.767 0.233 0.000
G59.0 Diabetic mononeuropathy
0.767 0.233 0.000
E13 Other specified diabetes mellitus
0.767 0.233 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.766 0.234 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.765 0.235 0.000
E87.2 Acidosis
0.763 0.237 0.000
S10-S19 Injuries to the neck
0.763 0.237 0.000
S90-S99 Injuries to the ankle and foot
0.763 0.237 0.000
M80-M85 Disorders of bone density and structure
0.763 0.237 0.000
M25 Other joint disorders, not elsewhere classified
0.762 0.238 0.000
R60 Oedema, not elsewhere classified
0.759 0.241 0.000
Y40 Systemic antibiotics
0.759 0.241 0.000
G62 Other polyneuropathies
0.759 0.241 0.000
R52.2 Other chronic pain
0.759 0.241 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.758 0.242 0.000
T39.0 Salicylates
0.757 0.243 0.000
I05-I09 Chronic rheumatic heart diseases
0.756 0.244 0.000
E89.0 Postprocedural hypothyroidism
0.754 0.246 0.000
I63 Cerebral infarction
0.754 0.246 0.000
G57.6 Lesion of plantar nerve
0.754 0.246 0.000
B35-B49 Mycoses
0.752 0.248 0.000
O00-O08 Pregnancy with abortive outcome
0.751 0.249 0.000
G51 Facial nerve disorders
0.749 0.251 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.748 0.252 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.747 0.253 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.744 0.256 0.000
T39.1 4-Aminophenol derivatives
0.744 0.256 0.000
E10.1 With ketoacidosis
0.744 0.256 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.743 0.257 0.000
X50-X57 Overexertion, travel and privation
0.743 0.257 0.000
E16.2 Hypoglycaemia, unspecified
0.743 0.257 0.000
E83 Disorders of mineral metabolism
0.741 0.259 0.000
F41.2 Mixed anxiety and depressive disorder
0.738 0.262 0.000
M21 Other acquired deformities of limbs
0.737 0.263 0.000
V40-V49 Car occupant injured in transport accident
0.737 0.263 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.735 0.265 0.000
S40-S49 Injuries to the shoulder and upper arm
0.735 0.265 0.000
M20 Acquired deformities of fingers and toes
0.735 0.265 0.000
Y44 Agents primarily affecting blood constituents
0.734 0.266 0.000
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.730 0.270 0.000
R52.9 Pain, unspecified
0.729 0.271 0.000
M24 Other specific joint derangements
0.729 0.271 0.000
T51.0 Ethanol
0.728 0.272 0.000
V80-V89 Other land transport accidents
0.727 0.273 0.000
Y57 Other and unspecified drugs and medicaments
0.727 0.273 0.000
R46 Symptoms and signs involving appearance and behaviour
0.727 0.273 0.000
Y42.5 Other oestrogens and progestogens
0.726 0.274 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.725 0.274 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.726 0.274 0.000
T79-T79 Certain early complications of trauma
0.724 0.276 0.000
F80-F89 Disorders of psychological development
0.723 0.277 0.000
S20 Superficial injury of thorax
0.722 0.278 0.000
M00-M03 Infectious arthropathies
0.720 0.280 0.000
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
0.720 0.280 0.000
W20-W49 Exposure to inanimate mechanical forces
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
E12 Malnutrition-related diabetes mellitus
0.717 0.283 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.717 0.283 0.000
X20-X29 Contact with venomous animals and plants
0.716 0.284 0.000
I63.9 Cerebral infarction, unspecified
0.716 0.284 0.000
E11.8 With unspecified complications
0.715 0.285 0.000
E11.7 With multiple complications
0.715 0.285 0.000
E11.6 With other specified complications
0.715 0.285 0.000
E11.0 With coma
0.715 0.285 0.000
M65-M68 Disorders of synovium and tendon
0.715 0.285 0.000
R33 Retention of urine
0.714 0.286 0.000
Y42.6 Antigonadotrophins, antioestrogens, antiandrogens, not elsewhere classified
0.714 0.286 0.000
R63.4 Abnormal weight loss
0.714 0.286 0.000
S61 Open wound of wrist and hand
0.714 0.286 0.000
T58 Toxic effect of carbon monoxide
0.713 0.287 0.000
T33-T35 Frostbite
0.712 0.288 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.712 0.288 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.712 0.288 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.712 0.288 0.000
T00-T07 Injuries involving multiple body regions
0.712 0.288 0.000
Q60-Q64 Congenital malformations of the urinary system
0.712 0.288 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.712 0.288 0.000
E00-E07 Disorders of thyroid gland
0.711 0.289 0.000
G57.3 Lesion of lateral popliteal nerve
0.710 0.290 0.000
T66-T78 Other and unspecified effects of external causes
0.710 0.290 0.000
E10.8 With unspecified complications
0.710 0.290 0.000
E10.7 With multiple complications
0.710 0.290 0.000
E10.6 With other specified complications
0.710 0.290 0.000
E10.0 With coma
0.710 0.290 0.000
E61 Deficiency of other nutrient elements
0.709 0.291 0.000
M35 Other systemic involvement of connective tissue
0.709 0.291 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.708 0.292 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.708 0.292 0.000
R40 Somnolence, stupor and coma
0.707 0.293 0.000
E87.3 Alkalosis
0.706 0.294 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.705 0.294 0.000
R26.8 Other and unspecified abnormalities of gait and mobility
0.705 0.295 0.000
B37 Candidiasis
0.704 0.296 0.000
Y35-Y36 Legal intervention and operations of war
0.703 0.296 0.000
Y10-Y34 Event of undetermined intent
0.703 0.296 0.000
Y00-Y09 Assault
0.703 0.296 0.000
X85-X99 Assault
0.703 0.296 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.703 0.296 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.703 0.296 0.000
X30-X39 Exposure to forces of nature
0.703 0.296 0.000
X10-X19 Contact with heat and hot substances
0.703 0.296 0.000
X00-X09 Exposure to smoke, fire and flames
0.703 0.296 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.703 0.296 0.000
W75-W84 Other accidental threats to breathing
0.703 0.296 0.000
W65-W74 Accidental drowning and submersion
0.703 0.296 0.000
W50-W64 Exposure to animate mechanical forces
0.703 0.296 0.000
V98-V99 Other and unspecified transport accidents
0.703 0.296 0.000
V95-V97 Air and space transport accidents
0.703 0.296 0.000
V90-V94 Water transport accidents
0.703 0.296 0.000
V70-V79 Bus occupant injured in transport accident
0.703 0.296 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.703 0.296 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.703 0.296 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.703 0.296 0.000
V01-V09 Pedestrian injured in transport accident
0.703 0.296 0.000
F40.0 Agoraphobia
0.703 0.297 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.703 0.297 0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.703 0.297 0.000
T85.6 Mechanical complication of other specified internal prosthetic devices, implants and grafts
0.702 0.298 0.000
G53 Cranial nerve disorders in diseases classified elsewhere
0.701 0.299 0.000
R52.1 Chronic intractable pain
0.701 0.299 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.701 0.299 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.700 0.300 0.000
Y42.7 Androgens and anabolic congeners
0.699 0.301 0.000
Y59 Other and unspecified vaccines and biological substances
0.699 0.301 0.000
Y58 Bacterial vaccines
0.699 0.301 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.699 0.301 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.699 0.301 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.699 0.301 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.699 0.301 0.000
Y48 Anaesthetics and therapeutic gases
0.699 0.301 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.699 0.301 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.699 0.301 0.000
M50-M54 Other dorsopathies
0.697 0.303 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.696 0.304 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.695 0.304 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.694 0.306 0.000
O85-O92 Complications predominantly related to the puerperium
0.693 0.307 0.000
E85 Amyloidosis
0.693 0.307 0.000
E84 Cystic fibrosis
0.693 0.307 0.000
E79 Disorders of purine and pyrimidine metabolism
0.693 0.307 0.000
E77 Disorders of glycoprotein metabolism
0.693 0.307 0.000
E76 Disorders of glycosaminoglycan metabolism
0.693 0.307 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.693 0.307 0.000
E74 Other disorders of carbohydrate metabolism
0.693 0.307 0.000
E73 Lactose intolerance
0.693 0.307 0.000
E72 Other disorders of amino-acid metabolism
0.693 0.307 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.693 0.307 0.000
E70 Disorders of aromatic amino-acid metabolism
0.693 0.307 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.693 0.307 0.000
Chapter VIII Diseases of the ear and mastoid process
0.691 0.309 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.691 0.309 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.689 0.311 0.000
G57.8 Other mononeuropathies of lower limb
0.689 0.311 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.689 0.311 0.000
R43 Disturbances of smell and taste
0.688 0.312 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.687 0.313 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.686 0.314 0.000
F43.2 Adjustment disorders
0.686 0.314 0.000
R86 Abnormal findings in specimens from male genital organs
0.684 0.315 0.000
E29 Testicular dysfunction
0.684 0.316 0.000
M22 Disorders of patella
0.683 0.317 0.000
Chapter XXII Codes for special purposes
0.683 0.317 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.681 0.319 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.681 0.319 0.000
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction
0.681 0.319 0.000
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
0.679 0.321 0.000
Q80-Q89 Other congenital malformations
0.678 0.322 0.000
G90-G99 Other disorders of the nervous system
0.678 0.322 0.000
R41.0 Disorientation, unspecified
0.677 0.323 0.000
S00-S09 Injuries to the head
0.676 0.324 0.000
M41 Scoliosis
0.676 0.324 0.000
G62.9 Polyneuropathy, unspecified
0.675 0.325 0.000
S60 Superficial injury of wrist and hand
0.675 0.325 0.000
R58 Haemorrhage, not elsewhere classified
0.674 0.326 0.000
R12 Heartburn
0.674 0.326 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.673 0.327 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.673 0.327 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.673 0.327 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.673 0.327 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.673 0.327 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.673 0.327 0.000
T36 Poisoning by systemic antibiotics
0.673 0.327 0.000
M20.2 Hallux rigidus
0.673 0.327 0.000
T85.5 Mechanical complication of gastro-intestinal prosthetic devices, implants and grafts
0.671 0.329 0.000
M86-M90 Other osteopathies
0.670 0.330 0.000
M20.5 Other deformities of toe(s) (acquired)
0.670 0.330 0.000
R44.8 Other and unspecified symptoms and signs involving general sensations and perceptions
0.670 0.330 0.000
T85.3 Mechanical complication of other ocular prosthetic devices, imnplants and grafts
0.670 0.330 0.000
R57 Shock, not elsewhere classified
0.669 0.331 0.000
M60-M63 Disorders of muscles
0.668 0.331 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.667 0.333 0.000
R41.8 Other and unspecified symptoms and signs involving cognitive functions and awareness
0.666 0.334 0.000
E87.4 Mixed disorder of acid-base balance
0.666 0.334 0.000
M84 Disorders of continuity of bone
0.666 0.334 0.000
G57.1 Meralgia paraesthetica
0.665 0.335 0.000
I69.3 Sequelae of cerebral infarction
0.664 0.336 0.000
E88 Other metabolic disorders
0.664 0.336 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.663 0.337 0.000
G52 Disorders of other cranial nerves
0.662 0.338 0.000
E46 Unspecified protein-energy malnutrition
0.662 0.338 0.000
V20-V29 Motorcycle rider injured in transport accident
0.661 0.339 0.000
R50 Fever of unknown origin
0.661 0.339 0.000
Y42.9 Other and unspecified hormone antagonists
0.661 0.339 0.000
Y42.4 Oral contraceptives
0.661 0.339 0.000
Y42.3 Insulin and oral hypoglycaemic [antidiabetic] drugs
0.661 0.339 0.000
Y42.2 Antithyroid drugs
0.661 0.339 0.000
Y42.1 Thyroid hormones and substitutes
0.661 0.339 0.000
Y42.0 Glucocorticoids and synthetic analogs
0.661 0.339 0.000
F60-F69 Disorders of adult personality and behaviour
0.661 0.339 0.000
T63 Toxic effect of contact with venomous animals
0.660 0.340 0.000
R68 Other general symptoms and signs
0.660 0.340 0.000
E14.8 With unspecified complications
0.659 0.341 0.000
E14.7 With multiple complications
0.659 0.341 0.000
E14.6 With other specified complications
0.659 0.341 0.000
E14.5 With peripheral circulatory complications
0.659 0.341 0.000
E14.4 With neurological complications
0.659 0.341 0.000
E14.2 Withrenal complications
0.659 0.341 0.000
E14.1 With ketoacidosis
0.659 0.341 0.000
E14.0 With coma
0.659 0.341 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.658 0.342 0.000
F70-F79 Mental retardation
0.658 0.342 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.658 0.342 0.000
G54 Nerve root and plexus disorders
0.657 0.343 0.000
R44.1 Visual hallucinations
0.657 0.343 0.000
R65 Systemic Inflammatory Response Syndrome [SIRS]
0.656 0.344 0.000
R62 Lack of expected normal physiological development
0.656 0.344 0.000
R64 Cachexia
0.656 0.344 0.000
F45 Somatoform disorders
0.655 0.345 0.000
F99-F99 Unspecified mental disorder
0.654 0.346 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.654 0.346 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.653 0.347 0.000
E67 Other hyperalimentation
0.653 0.347 0.000
E68 Sequelae of hyperalimentation
0.653 0.347 0.000
E65 Localised adiposity
0.653 0.347 0.000
E14.3 With ophthalmic complications
0.651 0.349 0.000
S62 Fracture at wrist and hand level
0.651 0.349 0.000
G63.2 Diabetic polyneuropathy
0.650 0.350 0.000
E24 Cushing's syndrome
0.648 0.352 0.000
G70-G73 Diseases of myoneural junction and muscle
0.648 0.352 0.000
O02 Other abnormal products of conception
0.646 0.354 0.000
F48 Other neurotic disorders
0.645 0.355 0.000
F44 Dissociative [conversion] disorders
0.645 0.355 0.000
F42 Obsessive-compulsive disorder
0.645 0.355 0.000
M23 Internal derangement of knee
0.645 0.355 0.000
T86 Failure and rejection of transplanted organs and tissues
0.644 0.356 0.000
T65 Toxic effect of other and unspecified substances
0.644 0.356 0.000
T62 Toxic effect of other noxious substances eaten as food
0.644 0.356 0.000
T61 Toxic effect of noxious substances eaten as seafood
0.644 0.356 0.000
T60 Toxic effect of pesticides
0.644 0.356 0.000
T59 Toxic effect of other gases, fumes and vapours
0.644 0.356 0.000
T57 Toxic effect of other inorganic substances
0.644 0.356 0.000
T56 Toxic effect of metals
0.644 0.356 0.000
T54 Toxic effect of corrosive substances
0.644 0.356 0.000
T53 Toxic effect of halogen derivatives of aliphatic and aromatic hydrocarbone
0.644 0.356 0.000
T52 Toxic effect of organic solvents
0.644 0.356 0.000
T64 Toxic effect of aflatoxin and other mycotoxin food contaminants
0.644 0.356 0.000
T55 Toxic effect of soaps and detergents
0.644 0.356 0.000
G61 Inflammatory polyneuropathy
0.644 0.356 0.000
S69 Other and unspecified injuries of wrist and hand
0.643 0.357 0.000
Y43.3 Other antineoplastic drugs
0.643 0.357 0.000
R29 Other symptoms and signs involving the nervous and musculoskeletal systems
0.643 0.357 0.000
S70-S79 Injuries to the hip and thigh
0.641 0.358 0.000
E61.1 Iron deficiency
0.640 0.360 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.640 0.360 0.000
M33 Dermatopolymyositis
0.640 0.360 0.000
M32 Systemic lupus erythematosus
0.640 0.360 0.000
M30 Polyarteritis nodosa and related conditions
0.640 0.360 0.000
M93 Other osteochondropathies
0.639 0.361 0.000
O46 Antepartum haemorrhage, not elsewhere classified
0.639 0.361 0.000
E27 Other disorders of adrenal gland
0.638 0.361 0.000
G55.0 Nerve root and plexus compressions in neoplastic disease
0.637 0.363 0.000
R45.8 Other symptoms and signs involving emotional state
0.637 0.363 0.000
S27 Injury of other and unspecified intrathoracic organs
0.637 0.363 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.637 0.363 0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis
0.636 0.364 0.000
M43 Other deforming dorsopathies
0.636 0.364 0.000
E23 Hypofunction and other disorders of pituitary gland
0.635 0.365 0.000
E15 Nondiabetic hypoglycaemic coma
0.634 0.366 0.000
M34 Systemic sclerosis
0.632 0.368 0.000
M51 Other intervertebral disk disorders
0.631 0.369 0.000
I00-I02 Acute rheumatic fever
0.631 0.369 0.000
E28 Ovarian dysfunction
0.631 0.369 0.000
O99.0 Anaemia complicating pregnancy, childbirth and the puerperium
0.629 0.371 0.000
I67.2 Cerebral atherosclerosis
0.629 0.371 0.000
M94 Other disorders of cartilage
0.628 0.372 0.000
T87 Complications peculiar to reattachment and amputation
0.628 0.372 0.000
G60 Hereditary and idiopathic neuropathy
0.628 0.372 0.000
G64 Other disorders of peripheral nervous system
0.628 0.372 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.627 0.373 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.627 0.373 0.000
Q35-Q37 Cleft lip and cleft palate
0.627 0.373 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.627 0.373 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.627 0.373 0.000
Q00-Q07 Congenital malformations of the nervous system
0.627 0.373 0.000
R16.1 Splenomegaly, not elsewhere classified
0.625 0.375 0.000
G51.0 Bell's palsy
0.624 0.375 0.000
F41.1 Generalised anxiety disorder
0.624 0.376 0.000
B15-B19 Viral hepatitis
0.624 0.376 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.624 0.376 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.624 0.376 0.000
Y45.1 Salicylates
0.623 0.377 0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.622 0.378 0.000
T39.4 Antirheumatics, not elsewhere classified
0.622 0.378 0.000
T39.2 Pyrazolone derivatives
0.622 0.378 0.000
E83.4 Disorders of magnesium metabolism
0.622 0.378 0.000
V10-V19 Pedal cyclist injured in transport accident
0.621 0.378 0.000
S80-S89 Injuries to the knee and lower leg
0.622 0.378 0.000
Y41.8 Other specified systemic anti-infectives and antiparasitics
0.621 0.379 0.000
G57.9 Mononeuropathy of lower limb, unspecified
0.620 0.379 0.000
G57.5 Tarsal tunnel syndrome
0.620 0.379 0.000
G57.4 Lesion of medial popliteal nerve
0.620 0.379 0.000
G57.2 Lesion of femoral nerve
0.620 0.379 0.000
G57.0 Lesion of sciatic nerve
0.620 0.379 0.000
T85.4 Mechanical complication of breast prosthesis and implant
0.619 0.381 0.000
I62 Other nontraumatic intracranial haemorrhage
0.619 0.381 0.000
R52.0 Acute pain
0.619 0.381 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.619 0.381 0.000
Y45.0 Opioids and related analgesics
0.618 0.382 0.000
M96 Postprocedural musculoskeletal disorders, not elsewhere classified
0.617 0.383 0.000
S29 Other and unspecified injuries of thorax
0.617 0.383 0.000
G58 Other mononeuropathies
0.617 0.383 0.000
Y43.1 Antineoplastic antimetabolites
0.616 0.384 0.000
X78 Intentional self-harm by sharp object
0.615 0.385 0.000
T85.8 Other complications of internal prosthetic devices, implants and grafts, not elsewhere classified
0.615 0.385 0.000
R63.0 Anorexia
0.613 0.387 0.000
T40.2 Other opioids
0.613 0.387 0.000
Q50-Q56 Congenital malformations of genital organs
0.612 0.388 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.611 0.389 0.000
T84.2 Mechanical complication of internal fixation device of other bones
0.611 0.389 0.000
Y43.4 Immunosuppressive agents
0.611 0.389 0.000
I05 Rheumatic mitral valve diseases
0.610 0.390 0.000
Y65 Other misadventures during surgical and medical care
0.610 0.390 0.000
S64 Injury of nerves at wrist and hand level
0.609 0.391 0.000
S65 Injury of blood vessels at wrist and hand level
0.609 0.391 0.000
M25.7 Osteophyte
0.608 0.392 0.000
R36 Urethral discharge
0.607 0.392 0.000
R34 Anuria and oliguria
0.607 0.392 0.000
R60.9 Oedema, unspecified
0.607 0.393 0.000
B95-B98 Bacterial, viral and other infectious agents
0.607 0.393 0.000
Y52.2 Other antidysrhythmic drugs, not elsewhere classified
0.607 0.393 0.000
E66.2 Extreme obesity with alveolar hypoventilation
0.607 0.393 0.000
E66.1 Drug-induced obesity
0.607 0.393 0.000
E66.0 Obesity due to excess calories
0.607 0.393 0.000
Y52.3 Coronary vasodilators, not elsewhere classified
0.605 0.395 0.000
I08 Multiple valve diseases
0.605 0.395 0.000
F40.9 Phobic anxiety disorder, unspecified
0.605 0.395 0.000
F40.8 Other phobic anxiety disorders
0.605 0.395 0.000
F40.1 Social phobias
0.605 0.395 0.000
O03 Spontaneous abortion
0.605 0.395 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.605 0.395 0.000
E34 Other endocrine disorders
0.605 0.395 0.000
E32 Diseases of thymus
0.605 0.395 0.000
E31 Polyglandular dysfunction
0.605 0.395 0.000
E30 Disorders of puberty, not elsewhere classified
0.605 0.395 0.000
E26 Hyperaldosteronism
0.605 0.395 0.000
E25 Adrenogenital disorders
0.605 0.395 0.000
E20 Hypoparathyroidism
0.605 0.395 0.000
S68 Traumatic amputation of wrist and hand
0.605 0.395 0.000
S67 Crushing injury of wrist and hand
0.605 0.395 0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.604 0.396 0.000
E89.8 Other postprocedural endocrine and metabolic disorders
0.604 0.396 0.000
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.604 0.396 0.000
E89.5 Postprocedural testicular hypofunction
0.604 0.396 0.000
E89.4 Postprocedural ovarian failure
0.604 0.396 0.000
E89.3 Postprocedural hypopituitarism
0.604 0.396 0.000
E89.2 Postprocedural hypoparathyroidism
0.604 0.396 0.000
E89.1 Postprocedural hypoinsulinaemia
0.604 0.396 0.000
I27 Other pulmonary heart diseases
0.604 0.396 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.604 0.396 0.000
Y51.7 Beta-Adrenoreceptor antagonists, not elsewhere classified
0.603 0.397 0.000
S20.8 Superficial injuries of other and unspecified parts of thorax
0.603 0.397 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.602 0.398 0.000
R60.0 Localised oedema
0.601 0.399 0.000
R39.1 Other difficulties with micturition
0.601 0.399 0.000
R45.1 Restlessness and agitation
0.601 0.399 0.000
Chapter VII Diseases of the eye and adnexa
0.601 0.399 0.000
I67.8 Other specified cerebrovascular diseases
0.601 0.399 0.000
X62 Intentional self-poisoning by and exposure to narcotics and psychodysleptics [hallucinogens], not elsewhere classified
0.601 0.399 0.000
S28 Crushing injury of thorax and traumatic amputation of part of thorax
0.600 0.400 0.000
S26 Injury of heart
0.600 0.400 0.000
S25 Injury of blood vessels of thorax
0.600 0.400 0.000
S24 Injury of nerves and spinal cord at thorax level
0.600 0.400 0.000
S23 Dislocation, sprain and strain of joints and ligaments of thorax
0.600 0.400 0.000
S21 Open wound of thorax
0.600 0.400 0.000
E13.9 Without complications
0.599 0.401 0.000
T85.9 Unspecified complication of internal prosthetic device, implant and graft
0.599 0.401 0.000
T85.1 Mechanical complication of implanted electronic stimulator of nervous system
0.599 0.401 0.000
T85.0 Mechanical complication of ventricular intracranial (communicating) shunt
0.599 0.401 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.598 0.402 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.598 0.402 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.597 0.403 0.000
G59.8 Other mononeuropathies in diseases classified elsewhere
0.597 0.403 0.000
G30-G32 Other degenerative diseases of the nervous system
0.596 0.404 0.000
G55.8 Nerve root and plexus compressions in other diseases classified elsewhere
0.596 0.404 0.000
M67 Other disorders of synovium and tendon
0.596 0.404 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.595 0.405 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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