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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs7516789
log Bayes Factor = 13.6841
Chromosome 1   position 67,945,956  (GRCh37) Explore rs7516789 on Ensembl!
Variant rs7516789 is part of Cluster X0071

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
Chapter V Mental and behavioural disorders
1.000 0.000 0.000
F10 Mental and behavioural disorders due to use of alcohol
1.000 0.000 0.000
Chapter X Diseases of the respiratory system
1.000 0.000 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.999 0.001 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.999 0.001 0.000
E11 Non-insulin-dependent diabetes mellitus
0.996 0.004 0.000
F10.0 Acute intoxication
0.996 0.004 0.000
Chapter XXI Factors influencing health status and contact with health services
0.995 0.005 0.000
J40-J47 Chronic lower respiratory diseases
0.995 0.005 0.000
M45-M49 Spondylopathies
0.994 0.006 0.000
Z02.8 Other examinations for administrative purposes
0.988 0.012 0.000
Z02 Examination and encounter for administrative purposes
0.987 0.013 0.000
Z00-Z13 Persons encountering health services for examination and investigation
0.987 0.013 0.000
M47 Spondylosis
0.986 0.014 0.000
J45 Asthma
0.983 0.017 0.000
Chapter VI Diseases of the nervous system
0.977 0.023 0.000
J45.9 Asthma, unspecified
0.975 0.025 0.000
M47.8 Other spondylosis
0.966 0.034 0.000
F10.2 Dependence syndrome
0.964 0.036 0.000
M80-M85 Disorders of bone density and structure
0.961 0.039 0.000
E20-E35 Disorders of other endocrine glands
0.958 0.042 0.000
E10 Insulin-dependent diabetes mellitus
0.957 0.043 0.000
M47.82 Other spondylosis (Cervical region)
0.955 0.045 0.000
F10.1 Harmful use
0.953 0.047 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.949 0.051 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.945 0.055 0.000
Chapter IX Diseases of the circulatory system
0.939 0.061 0.000
E11.9 Without complications
0.938 0.062 0.000
G90-G99 Other disorders of the nervous system
0.937 0.063 0.000
E11.3 With ophthalmic complications
0.935 0.065 0.000
Z40-Z54 Persons encountering health services for specific procedures and health care
0.932 0.068 0.000
E70-E90 Metabolic disorders
0.923 0.077 0.000
J20-J22 Other acute lower respiratory infections
0.922 0.078 0.000
Z50 Care involving use of rehabilitation procedures
0.919 0.081 0.000
M81 Osteoporosis without pathological fracture
0.915 0.085 0.000
J30-J39 Other diseases of upper respiratory tract
0.911 0.089 0.000
E11.5 With peripheral circulatory complications
0.902 0.098 0.000
M48 Other spondylopathies
0.898 0.102 0.000
M47.9 Spondylosis, unspecified
0.894 0.106 0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases
0.890 0.110 0.000
S00-S09 Injuries to the head
0.883 0.117 0.000
Z08 Follow-up examination after treatment for malignant neoplasm
0.880 0.120 0.000
G93 Other disorders of brain
0.879 0.121 0.000
I20-I25 Ischaemic heart diseases
0.877 0.123 0.000
M81.9 Osteoporosis, unspecified
0.877 0.123 0.000
F10.3 Withdrawal state
0.874 0.126 0.000
I60-I69 Cerebrovascular diseases
0.872 0.128 0.000
J44 Other chronic obstructive pulmonary disease
0.871 0.129 0.000
S80-S89 Injuries to the knee and lower leg
0.869 0.131 0.000
I69 Sequelae of cerebrovascular disease
0.868 0.132 0.000
M65-M68 Disorders of synovium and tendon
0.868 0.132 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.868 0.132 0.000
I20 Angina pectoris
0.866 0.134 0.000
J22 Unspecified acute lower respiratory infection
0.864 0.136 0.000
E10.4 With neurological complications
0.860 0.140 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.859 0.141 0.000
Chapter VII Diseases of the eye and adnexa
0.858 0.142 0.000
Z50.8 Care involving use of rehabilitation procedures
0.854 0.146 0.000
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction
0.850 0.150 0.000
Z42 Follow-up care involving plastic surgery
0.843 0.157 0.000
E11.4 With neurological complications
0.843 0.157 0.000
J34 Other disorders of nose and nasal sinuses
0.840 0.160 0.000
F40 Phobic anxiety disorders
0.836 0.164 0.000
E83 Disorders of mineral metabolism
0.836 0.164 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.831 0.169 0.000
E50-E64 Other nutritional deficiencies
0.825 0.174 0.000
G99 Other disorders of nervous system in diseases classified elsewhere
0.823 0.177 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.821 0.179 0.000
J00-J06 Acute upper respiratory infections
0.821 0.179 0.000
M81.99 Osteoporosis, unspecified (Site unspecified)
0.820 0.180 0.000
I20.0 Unstable angina
0.819 0.181 0.000
Z08.0 Follow-up examination after surgery for malignant neoplasm
0.818 0.182 0.000
E10.3 With ophthalmic complications
0.813 0.187 0.000
M48.0 Spinal stenosis
0.812 0.188 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.811 0.189 0.000
F43 Reaction to severe stress, and adjustment disorders
0.810 0.190 0.000
J60-J70 Lung diseases due to external agents
0.808 0.191 0.000
Z41 Procedures for purposes other than remedying health state
0.807 0.193 0.000
J44.9 Chronic obstructive pulmonary disease, unspecified
0.806 0.194 0.000
Chapter XX External causes of morbidity and mortality
0.804 0.196 0.000
F10.9 Unspecified mental and behavioural disorder
0.801 0.199 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.801 0.199 0.000
G70-G73 Diseases of myoneural junction and muscle
0.799 0.201 0.000
M47.92 Spondylosis, unspecified (Cervical region)
0.798 0.202 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.797 0.203 0.000
S89 Other and unspecified injuries of lower leg
0.795 0.205 0.000
E23 Hypofunction and other disorders of pituitary gland
0.789 0.211 0.000
J90-J94 Other diseases of pleura
0.788 0.212 0.000
Z13 Special screening examination for other diseases and disorders
0.785 0.215 0.000
E73 Lactose intolerance
0.783 0.217 0.000
I20.9 Angina pectoris, unspecified
0.782 0.218 0.000
F99-F99 Unspecified mental disorder
0.782 0.218 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.781 0.219 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.780 0.219 0.000
J95-J99 Other diseases of the respiratory system
0.780 0.220 0.000
M47.96 Spondylosis, unspecified (Lumbar region)
0.780 0.220 0.000
T66-T78 Other and unspecified effects of external causes
0.778 0.222 0.000
E85 Amyloidosis
0.778 0.222 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.775 0.225 0.000
J43 Emphysema
0.775 0.225 0.000
Z50.2 Alcohol rehabilitation
0.773 0.227 0.000
J40 Bronchitis, not specified as acute or chronic
0.770 0.230 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.768 0.232 0.000
E29 Testicular dysfunction
0.766 0.234 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.765 0.235 0.000
E14 Unspecified diabetes mellitus
0.765 0.235 0.000
Z42.0 Follow-up care involving plastic surgery of head and neck
0.765 0.235 0.000
M91-M94 Chondropathies
0.765 0.235 0.000
M47.86 Other spondylosis (Lumbar region)
0.764 0.235 0.000
M86-M90 Other osteopathies
0.763 0.237 0.000
Z50.7 Occupational therapy and vocational rehabilitation, not elsewhere classified
0.762 0.238 0.000
M85 Other disorders of bone density and structure
0.760 0.240 0.000
S06 Intracranial injury
0.759 0.241 0.000
E10.2 With renal complications
0.758 0.242 0.000
Z29 Need for other prophylactic measures
0.757 0.243 0.000
F42 Obsessive-compulsive disorder
0.756 0.243 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.756 0.244 0.000
F40.2 Specific (isolated) phobias
0.755 0.245 0.000
E26 Hyperaldosteronism
0.753 0.247 0.000
Z50.9 Care involving use of rehabilitation procedure, unspecified
0.752 0.248 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.752 0.248 0.000
E34 Other endocrine disorders
0.750 0.250 0.000
M20-M25 Other joint disorders
0.749 0.251 0.000
I30-I52 Other forms of heart disease
0.748 0.252 0.000
J31 Chronic rhinitis, nasopharyngitis and pharyngitis
0.747 0.253 0.000
G93.8 Other specified disorders of brain
0.747 0.253 0.000
S81 Open wound of lower leg
0.747 0.253 0.000
I05-I09 Chronic rheumatic heart diseases
0.747 0.253 0.000
F60-F69 Disorders of adult personality and behaviour
0.745 0.255 0.000
J38 Diseases of vocal cords and larynx, not elsewhere classified
0.744 0.256 0.000
W00-W19 Falls
0.744 0.256 0.000
M65 Synovitis and tenosynovitis
0.744 0.256 0.000
F12 Mental and behavioural disorders due to use of cannabinoids
0.743 0.257 0.000
S89.9 Unspecified injury of lower leg
0.742 0.258 0.000
Z21 Asymptomatic human immunodeficiency virus [HIV] infection status
0.742 0.258 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.742 0.258 0.000
G35 Multiple sclerosis
0.742 0.258 0.000
J34.8 Other specified disorders of nose and nasal sinuses
0.742 0.258 0.000
J46 Status asthmaticus
0.742 0.258 0.000
F41 Other anxiety disorders
0.741 0.259 0.000
M47.2 Other spondylosis with radiculopathy
0.738 0.261 0.000
G93.3 Postviral fatigue syndrome
0.738 0.262 0.000
E28 Ovarian dysfunction
0.736 0.264 0.000
E65-E68 Obesity and other hyperalimentation
0.735 0.264 0.000
Z50.5 Speech therapy
0.735 0.265 0.000
I35 Nonrheumatic aortic valve disorders
0.735 0.265 0.000
M00-M03 Infectious arthropathies
0.734 0.266 0.000
G95 Other diseases of spinal cord
0.733 0.267 0.000
S10-S19 Injuries to the neck
0.731 0.269 0.000
I35.0 Aortic (valve) stenosis
0.729 0.271 0.000
E27 Other disorders of adrenal gland
0.728 0.272 0.000
E22 Hyperfunction of pituitary gland
0.728 0.272 0.000
M96 Postprocedural musculoskeletal disorders, not elsewhere classified
0.728 0.272 0.000
M84 Disorders of continuity of bone
0.727 0.273 0.000
Z13.1 Special screening examination for diabetes mellitus
0.727 0.273 0.000
Z46 Fitting and adjustment of other devices
0.727 0.273 0.000
I69.0 Sequelae of subarachnoid haemorrhage
0.726 0.274 0.000
S09 Other and unspecified injuries of head
0.726 0.274 0.000
G93.4 Encephalopathy, unspecified
0.725 0.275 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.724 0.276 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.724 0.276 0.000
E53 Deficiency of other B group vitamins
0.724 0.276 0.000
Z44 Fitting and adjustment of external prosthetic device
0.722 0.278 0.000
S02 Fracture of skull and facial bones
0.722 0.278 0.000
M47.80 Other spondylosis (Multiple sites in spine)
0.721 0.279 0.000
M47.1 Other spondylosis with myelopathy
0.721 0.279 0.000
Z00 General examination and investigation of persons without complaint or reported diagnosis
0.720 0.280 0.000
J45.0 Predominantly allergic asthma
0.720 0.280 0.000
I20.8 Other forms of angina pectoris
0.720 0.280 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.720 0.280 0.000
Chapter XXII Codes for special purposes
0.719 0.280 0.000
H04 Disorders of lachrymal system
0.719 0.281 0.000
E10.9 Without complications
0.718 0.282 0.000
M81.98 Osteoporosis, unspecified (Other)
0.718 0.282 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
Z41.1 Other plastic surgery for unacceptable cosmetic appearance
0.717 0.283 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.717 0.283 0.000
F80-F89 Disorders of psychological development
0.717 0.283 0.000
F70-F79 Mental retardation
0.717 0.283 0.000
F10.8 Other mental and behavioural disorders
0.717 0.283 0.000
F10.7 Residual and late-onset psychotic disorder
0.717 0.283 0.000
F10.6 Amnesic syndrome
0.717 0.283 0.000
F10.5 Psychotic disorder
0.717 0.283 0.000
F10.4 Withdrawal state with delirium
0.717 0.283 0.000
Z54 Convalescence
0.717 0.283 0.000
Chapter VIII Diseases of the ear and mastoid process
0.717 0.283 0.000
H30-H36 Disorders of choroid and retina
0.717 0.283 0.000
F19 Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances
0.717 0.283 0.000
F18 Mental and behavioural disorders due to use of volatile solvents
0.717 0.283 0.000
F16 Mental and behavioural disorders due to use of hallucinogens
0.717 0.283 0.000
F15 Mental and behavioural disorders due to use of other stimulants, including caffeine
0.717 0.283 0.000
F14 Mental and behavioural disorders due to use of cocaine
0.717 0.283 0.000
F13 Mental and behavioural disorders due to use of sedatives or hypnotics
0.717 0.283 0.000
F11 Mental and behavioural disorders due to use of opioids
0.717 0.283 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.717 0.283 0.000
M48.06 Spinal stenosis (Lumbar region)
0.717 0.283 0.000
Z50.0 Cardiac rehabilitation
0.717 0.283 0.000
E13 Other specified diabetes mellitus
0.716 0.283 0.000
E12 Malnutrition-related diabetes mellitus
0.716 0.283 0.000
M60-M63 Disorders of muscles
0.716 0.283 0.000
I69.8 Sequelae of other and unspecified cerebrovascular diseases
0.715 0.285 0.000
J69 Pneumonitis due to solids and liquids
0.714 0.286 0.000
E11.8 With unspecified complications
0.714 0.286 0.000
E11.7 With multiple complications
0.714 0.286 0.000
E11.6 With other specified complications
0.714 0.286 0.000
E11.1 With ketoacidosis
0.714 0.286 0.000
E11.0 With coma
0.714 0.286 0.000
J41 Simple and mucopurulent chronic bronchitis
0.713 0.287 0.000
G99.0 Autonomic neuropathy in endocrine and metabolic diseases
0.713 0.287 0.000
S40-S49 Injuries to the shoulder and upper arm
0.713 0.287 0.000
M70-M79 Other soft tissue disorders
0.713 0.287 0.000
M49 Spondylopathies in diseases classified elsewhere
0.713 0.287 0.000
E83.1 Disorders of iron metabolism
0.711 0.288 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
0.711 0.289 0.000
E40-E46 Malnutrition
0.710 0.289 0.000
M80 Osteoporosis with pathological fracture
0.710 0.290 0.000
Z02.9 Examination for administrative purposes, unspecified
0.708 0.292 0.000
Z02.7 Issue of medical certificate
0.708 0.292 0.000
Z02.6 Examination for insurance purposes
0.708 0.292 0.000
Z02.5 Examination for participation in sport
0.708 0.292 0.000
Z02.4 Examination for driving licence
0.708 0.292 0.000
Z02.3 Examination for recruitment to armed forces
0.708 0.292 0.000
Z02.2 Examination for admission to residential institution
0.708 0.292 0.000
Z02.1 Pre-employment examination
0.708 0.292 0.000
Z02.0 Examination for admission to educational institution
0.708 0.292 0.000
E10.1 With ketoacidosis
0.707 0.292 0.000
Z10 Routine general health check-up of defined subpopulation
0.707 0.293 0.000
M47.0 Anterior spinal and vertebral artery compression syndromes
0.707 0.293 0.000
Z43 Attention to artificial openings
0.705 0.294 0.000
S80 Superficial injury of lower leg
0.705 0.295 0.000
J45.8 Mixed asthma
0.705 0.295 0.000
J45.1 Nonallergic asthma
0.705 0.295 0.000
G59 Mononeuropathy in diseases classified elsewhere
0.705 0.295 0.000
Z70-Z76 Persons encountering health services in other circumstances
0.704 0.296 0.000
F43.2 Adjustment disorders
0.704 0.296 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.703 0.297 0.000
I69.1 Sequelae of intracerebral haemorrhage
0.701 0.299 0.000
J36 Peritonsillar abscess
0.701 0.299 0.000
Z42.9 Follow-up care involving plastic surgery, unspecified
0.699 0.301 0.000
J34.3 Hypertrophy of nasal turbinates
0.697 0.303 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.697 0.303 0.000
M48.5 Collapsed vertebra, not elsewhere classified
0.696 0.304 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.695 0.305 0.000
J86 Pyothorax
0.693 0.307 0.000
M47.89 Other spondylosis (Site unspecified)
0.693 0.307 0.000
M47.88 Other spondylosis (Sacral and sacrococcygeal region)
0.693 0.307 0.000
M47.85 Other spondylosis (Thoracolumbar region)
0.693 0.307 0.000
M47.84 Other spondylosis (Thoracic region)
0.693 0.307 0.000
M47.83 Other spondylosis (Cervicothoracic region)
0.693 0.307 0.000
M47.81 Other spondylosis (Occipito-atlanto-axial region)
0.693 0.307 0.000
S01 Open wound of head
0.692 0.308 0.000
M81.4 Drug-induced osteoporosis
0.692 0.308 0.000
J00 Acute nasopharyngitis [common cold]
0.691 0.309 0.000
M81.90 Osteoporosis, unspecified (Multiple sites)
0.691 0.309 0.000
J44.8 Other specified chronic obstructive pulmonary disease
0.691 0.309 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.691 0.309 0.000
G96 Other disorders of central nervous system
0.690 0.310 0.000
M83 Adult osteomalacia
0.689 0.311 0.000
M82 Osteoporosis in diseases classified elsewhere
0.689 0.311 0.000
Q50-Q56 Congenital malformations of genital organs
0.689 0.311 0.000
J42 Unspecified chronic bronchitis
0.687 0.312 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.687 0.313 0.000
E32 Diseases of thymus
0.687 0.313 0.000
E31 Polyglandular dysfunction
0.687 0.313 0.000
E30 Disorders of puberty, not elsewhere classified
0.687 0.313 0.000
E25 Adrenogenital disorders
0.687 0.313 0.000
E24 Cushing's syndrome
0.687 0.313 0.000
E20 Hypoparathyroidism
0.687 0.313 0.000
M50-M54 Other dorsopathies
0.686 0.314 0.000
E10.8 With unspecified complications
0.686 0.314 0.000
E10.7 With multiple complications
0.686 0.314 0.000
E10.6 With other specified complications
0.686 0.314 0.000
E10.5 With peripheral circulatory complications
0.686 0.314 0.000
E10.0 With coma
0.686 0.314 0.000
J95 Postprocedural respiratory disorders, not elsewhere classified
0.686 0.314 0.000
E11.2 With renal complications
0.684 0.316 0.000
M67 Other disorders of synovium and tendon
0.683 0.317 0.000
E73.9 Lactose intolerance, unspecified
0.683 0.317 0.000
F48 Other neurotic disorders
0.680 0.319 0.000
F44 Dissociative [conversion] disorders
0.680 0.319 0.000
J09-J18 Influenza and pneumonia
0.680 0.320 0.000
S05 Injury of eye and orbit
0.680 0.320 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.679 0.321 0.000
T33-T35 Frostbite
0.678 0.322 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.678 0.322 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.678 0.322 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.678 0.322 0.000
T00-T07 Injuries involving multiple body regions
0.678 0.322 0.000
J30 Vasomotor and allergic rhinitis
0.678 0.322 0.000
Z08.2 Follow-up examination after chemotherapy for malignant neoplasm
0.677 0.323 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.677 0.323 0.000
M48.09 Spinal stenosis (Site unspecified)
0.677 0.323 0.000
Q00-Q07 Congenital malformations of the nervous system
0.676 0.324 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.674 0.326 0.000
G20-G26 Extrapyramidal and movement disorders
0.674 0.326 0.000
M95 Other acquired deformities of musculoskeletal system and connective tissue
0.673 0.327 0.000
I00-I02 Acute rheumatic fever
0.673 0.327 0.000
E83.3 Disorders of phosphorus metabolism
0.673 0.327 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.672 0.328 0.000
G94 Other disorders of brain in diseases classified elsewhere
0.672 0.328 0.000
G90 Disorders of autonomic nervous system
0.672 0.328 0.000
G98 Other disorders of nervous system, not elsewhere classified
0.672 0.328 0.000
G92 Toxic encephalopathy
0.672 0.328 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.671 0.329 0.000
J20 Acute bronchitis
0.670 0.330 0.000
M46 Other inflammatory spondylopathies
0.669 0.331 0.000
S20-S29 Injuries to the thorax
0.668 0.332 0.000
H36 Retinal disorders in diseases classified elsewhere
0.667 0.333 0.000
M24 Other specific joint derangements
0.666 0.334 0.000
F41.2 Mixed anxiety and depressive disorder
0.665 0.335 0.000
H02 Other disorders of eyelid
0.663 0.337 0.000
J35 Chronic diseases of tonsils and adenoids
0.663 0.337 0.000
V10-V19 Pedal cyclist injured in transport accident
0.662 0.338 0.000
E84 Cystic fibrosis
0.662 0.338 0.000
E79 Disorders of purine and pyrimidine metabolism
0.662 0.338 0.000
E77 Disorders of glycoprotein metabolism
0.662 0.338 0.000
E76 Disorders of glycosaminoglycan metabolism
0.662 0.338 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.662 0.338 0.000
E74 Other disorders of carbohydrate metabolism
0.662 0.338 0.000
E72 Other disorders of amino-acid metabolism
0.662 0.338 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.662 0.338 0.000
E70 Disorders of aromatic amino-acid metabolism
0.662 0.338 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.662 0.338 0.000
H55-H59 Other disorders of eye and adnexa
0.662 0.338 0.000
I69.3 Sequelae of cerebral infarction
0.661 0.338 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.661 0.339 0.000
Z01 Other special examinations and investigations of persons without complaint or reported diagnosis
0.661 0.339 0.000
G93.9 Disorder of brain, unspecified
0.661 0.339 0.000
J21 Acute bronchiolitis
0.661 0.339 0.000
Q80-Q89 Other congenital malformations
0.660 0.340 0.000
T91 Sequelae of injuries of neck and trunk
0.659 0.341 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.659 0.341 0.000
Z50.6 Orthoptic training
0.659 0.341 0.000
Z50.4 Psychotherapy, not elsewhere classified
0.659 0.341 0.000
Z50.3 Drug rehabilitation
0.659 0.341 0.000
J47 Bronchiectasis
0.659 0.341 0.000
T79-T79 Certain early complications of trauma
0.658 0.341 0.000
T78 Adverse effects, not elsewhere classified
0.659 0.341 0.000
H04.5 Stenosis and insufficiency of lachrymal passages
0.658 0.342 0.000
J34.2 Deviated nasal septum
0.658 0.342 0.000
J03 Acute tonsillitis
0.658 0.342 0.000
J90 Pleural effusion, not elsewhere classified
0.657 0.343 0.000
M81.8 Other osteoporosis
0.656 0.344 0.000
M81.6 Localised osteoporosis [Lequesne]
0.656 0.344 0.000
M81.5 Idiopathic osteoporosis
0.656 0.344 0.000
M81.3 Postsurgical malabsorption osteoporosis
0.656 0.344 0.000
M81.2 Osteoporosis of disuse
0.656 0.344 0.000
M81.1 Postoophorectomy osteoporosis
0.656 0.344 0.000
M81.0 Postmenopausal osteoporosis
0.656 0.344 0.000
I20.1 Angina pectoris with documented spasm
0.656 0.344 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.655 0.345 0.000
S50-S59 Injuries to the elbow and forearm
0.654 0.346 0.000
J37 Chronic laryngitis and laryngotracheitis
0.653 0.347 0.000
G30-G32 Other degenerative diseases of the nervous system
0.651 0.349 0.000
Chapter I Certain infectious and parasitic diseases
0.651 0.349 0.000
E53.8 Deficiency of other specified B group vitamins
0.651 0.349 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.650 0.350 0.000
Z22 Carrier of infectious disease
0.649 0.351 0.000
G99.2 Myelopathy in diseases classified elsewhere
0.649 0.351 0.000
F45 Somatoform disorders
0.649 0.351 0.000
M40-M43 Deforming dorsopathies
0.649 0.351 0.000
L97 Ulcer of lower limb, not elsewhere classified
0.648 0.352 0.000
I26 Pulmonary embolism
0.648 0.352 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.647 0.353 0.000
Z29.0 Isolation
0.647 0.353 0.000
J69.0 Pneumonitis due to food and vomit
0.647 0.353 0.000
G70 Myasthenia gravis and other myoneural disorders
0.646 0.354 0.000
E83.4 Disorders of magnesium metabolism
0.645 0.354 0.000
M45 Ankylosing spondylitis
0.645 0.355 0.000
I61 Intracerebral haemorrhage
0.645 0.355 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.644 0.356 0.000
M48.9 Spondylopathy, unspecified
0.644 0.356 0.000
M48.8 Other specified spondylopathies
0.644 0.356 0.000
M48.4 Fatigue fracture of vertebra
0.644 0.356 0.000
M48.3 Traumatic spondylopathy
0.644 0.356 0.000
M48.2 Kissing spine
0.644 0.356 0.000
M48.1 Ankylosing hyperostosis [Forestier]
0.644 0.356 0.000
R42 Dizziness and giddiness
0.644 0.356 0.000
J38.7 Other diseases of larynx
0.644 0.356 0.000
E88 Other metabolic disorders
0.642 0.358 0.000
E21.0 Primary hyperparathyroidism
0.642 0.358 0.000
T92 Sequelae of injuries of upper limb
0.642 0.358 0.000
E87.6 Hypokalaemia
0.642 0.358 0.000
T51 Toxic effect of alcohol
0.641 0.359 0.000
M47.98 Spondylosis, unspecified (Sacral and sacrococcygeal region)
0.641 0.359 0.000
M47.95 Spondylosis, unspecified (Thoracolumbar region)
0.641 0.359 0.000
M47.94 Spondylosis, unspecified (Thoracic region)
0.641 0.359 0.000
M47.93 Spondylosis, unspecified (Cervicothoracic region)
0.641 0.359 0.000
M47.91 Spondylosis, unspecified (Occipito-atlanto-axial region)
0.641 0.359 0.000
G51 Facial nerve disorders
0.640 0.360 0.000
Z28 Immunisation not carried out
0.638 0.361 0.000
Z27 Need for immunisation against combinations of infectious diseases
0.638 0.361 0.000
Z26 Need for immunisation against other single infectious diseases
0.638 0.361 0.000
Z25 Need for immunisation against other single viral diseases
0.638 0.361 0.000
Z24 Need for immunisation against certain single viral diseases
0.638 0.361 0.000
Z23 Need for immunisation against single bacterial diseases
0.638 0.361 0.000
Z20 Contact with and exposure to communicable diseases
0.638 0.361 0.000
G93.6 Cerebral oedema
0.638 0.362 0.000
E23.0 Hypopituitarism
0.638 0.362 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.638 0.362 0.000
Z08.7 Follow-up examination after combined treatment for malignant neoplasm
0.638 0.362 0.000
S06.0 Concussion
0.637 0.363 0.000
M21 Other acquired deformities of limbs
0.637 0.363 0.000
G59.0 Diabetic mononeuropathy
0.636 0.363 0.000
Z42.3 Follow-up care involving plastic surgery of upper extremity
0.635 0.365 0.000
S08 Traumatic amputation of part of head
0.633 0.367 0.000
S07 Crushing injury of head
0.633 0.367 0.000
S04 Injury of cranial nerves
0.633 0.367 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.633 0.367 0.000
I49 Other cardiac arrhythmias
0.633 0.367 0.000
E85.4 Organ-limited amyloidosis
0.633 0.367 0.000
S81.0 Open wound of knee
0.631 0.369 0.000
H36.0 Diabetic retinopathy
0.631 0.369 0.000
Z08.1 Follow-up examination after radiotherapy for malignant neoplasm
0.631 0.369 0.000
G93.7 Reye's syndrome
0.630 0.369 0.000
G93.5 Compression of brain
0.630 0.369 0.000
G93.2 Benign intracranial hypertension
0.630 0.369 0.000
G93.1 Anoxic brain damage, not elsewhere classified
0.630 0.369 0.000
J31.0 Chronic rhinitis
0.630 0.370 0.000
Z11 Special screening examination for infectious and parasitic diseases
0.629 0.371 0.000
I23 Certain current complications following acute myocardial infarction
0.629 0.371 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.629 0.371 0.000
M81.97 Osteoporosis, unspecified (Ankle and foot)
0.629 0.371 0.000
M81.96 Osteoporosis, unspecified (Lower leg)
0.629 0.371 0.000
M81.95 Osteoporosis, unspecified (Pelvic region and thigh)
0.629 0.371 0.000
M81.94 Osteoporosis, unspecified (Hand)
0.629 0.371 0.000
M81.93 Osteoporosis, unspecified (Forearm)
0.629 0.371 0.000
M81.92 Osteoporosis, unspecified (Upper arm)
0.629 0.371 0.000
M81.91 Osteoporosis, unspecified (Shoulder region)
0.629 0.371 0.000
Z52 Donors of organs and tissues
0.629 0.371 0.000
E29.1 Testicular hypofunction
0.629 0.371 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.626 0.374 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.626 0.374 0.000
F99 Mental disorder, not otherwise specified
0.625 0.374 0.000
H02.9 Disorder of eyelid, unspecified
0.625 0.375 0.000
T93 Sequelae of injuries of lower limb
0.624 0.376 0.000
S88 Traumatic amputation of lower leg
0.623 0.377 0.000
S87 Crushing injury of lower leg
0.623 0.377 0.000
S86 Injury of muscle and tendon at lower leg level
0.623 0.377 0.000
S85 Injury of blood vessels at lower leg level
0.623 0.377 0.000
S84 Injury of nerves at lower leg level
0.623 0.377 0.000
I69.2 Sequelae of other nontraumatic intracranial haemorrhage
0.622 0.377 0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.622 0.377 0.000
M66 Spontaneous rupture of synovium and tendon
0.622 0.377 0.000
Z13.6 Special screening examination for cardiovascular disorders
0.622 0.377 0.000
H10-H13 Disorders of conjunctiva
0.622 0.378 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.622 0.378 0.000
Q35-Q37 Cleft lip and cleft palate
0.622 0.378 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.622 0.378 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.622 0.378 0.000
M47.99 Spondylosis, unspecified (Site unspecified)
0.622 0.378 0.000
W07 Fall involving chair
0.622 0.378 0.000
F41.0 Panic disorder [episodic paroxysmal anxiety]
0.620 0.380 0.000
E85.9 Amyloidosis, unspecified
0.620 0.380 0.000
M47.90 Spondylosis, unspecified (Multiple sites in spine)
0.620 0.380 0.000
E78.2 Mixed hyperlipidaemia
0.620 0.380 0.000
E83.5 Disorders of calcium metabolism
0.619 0.381 0.000
Z49 Care involving dialysis
0.619 0.381 0.000
Z08.9 Follow-up examination after unspecified treatment for malignant neoplasm
0.618 0.381 0.000
F42.9 Obsessive-compulsive disorder, unspecified
0.618 0.381 0.000
G93.0 Cerebral cysts
0.618 0.381 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.618 0.382 0.000
H01 Other inflammation of eyelid
0.618 0.382 0.000
J95.8 Other postprocedural respiratory disorders
0.618 0.382 0.000
I08 Multiple valve diseases
0.618 0.382 0.000
S90-S99 Injuries to the ankle and foot
0.617 0.383 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.617 0.383 0.000
J43.9 Emphysema, unspecified
0.617 0.383 0.000
G58 Other mononeuropathies
0.617 0.383 0.000
E78.5 Hyperlipidaemia, unspecified
0.617 0.383 0.000
M65.3 Trigger finger
0.616 0.384 0.000
M99 Biomechanical lesions, not elsewhere classified
0.616 0.384 0.000
M96.8 Other postprocedural musculoskeletal disorders
0.616 0.384 0.000
I22 Subsequent myocardial infarction
0.615 0.385 0.000
M48.07 Spinal stenosis (Lumbosacral region)
0.614 0.386 0.000
E55 Vitamin D deficiency
0.614 0.386 0.000
F17 Mental and behavioural disorders due to use of tobacco
0.614 0.386 0.000
H04.8 Other disorders of lachrymal system
0.614 0.386 0.000
L40-L45 Papulosquamous disorders
0.613 0.387 0.000
E80.4 Gilbert's syndrome
0.613 0.387 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.612 0.388 0.000
F30-F39 Mood [affective] disorders
0.612 0.388 0.000
J38.2 Nodules of vocal cords
0.612 0.388 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.611 0.389 0.000
M54 Dorsalgia
0.611 0.389 0.000
G71 Primary disorders of muscles
0.611 0.389 0.000
S02.3 Fracture of orbital floor
0.610 0.389 0.000
J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified
0.610 0.390 0.000
E23.2 Diabetes insipidus
0.610 0.390 0.000
Z57 Occupational exposure to risk-factors
0.610 0.390 0.000
E14.3 With ophthalmic complications
0.610 0.390 0.000
R41 Other symptoms and signs involving cognitive functions and awareness
0.610 0.390 0.000
E26.0 Primary hyperaldosteronism
0.607 0.393 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.607 0.393 0.000
J04 Acute laryngitis and tracheitis
0.606 0.394 0.000
Z42.8 Follow-up care involving plastic surgery of other body part
0.605 0.395 0.000
Z42.4 Follow-up care involving plastic surgery of lower extremity
0.605 0.395 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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