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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs7521578
log Bayes Factor = 17.1428
Chromosome 1   position 158,736,201  (GRCh37) Explore rs7521578 on Ensembl!
Variant rs7521578 is part of Cluster X0122

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
K80 Cholelithiasis
1.000 0.000 0.000
Chapter XI Diseases of the digestive system
1.000 0.000 0.000
E10-E14 Diabetes mellitus
1.000 0.000 0.000
K80-K87 Disorders of gallbladder, biliary tract and pancreas
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
E11 Non-insulin-dependent diabetes mellitus
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
E11.9 Without complications
0.999 0.001 0.000
K00-K14 Diseases of oral cavity, salivary glands and jaws
0.998 0.002 0.000
K80.2 Calculus of gallbladder without cholecystitis
0.997 0.003 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.992 0.008 0.000
K80.5 Calculus of bile duct without cholangitis or cholecystitis
0.991 0.009 0.000
Chapter V Mental and behavioural disorders
0.990 0.010 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.987 0.013 0.000
Chapter VI Diseases of the nervous system
0.986 0.014 0.000
F41 Other anxiety disorders
0.984 0.016 0.000
M20-M25 Other joint disorders
0.983 0.017 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.983 0.017 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.983 0.017 0.000
F41.9 Anxiety disorder, unspecified
0.981 0.019 0.000
K80.1 Calculus of gallbladder with other cholecystitis
0.976 0.024 0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems
0.973 0.027 0.000
K13 Other diseases of lip and oral mucosa
0.973 0.027 0.000
Chapter VII Diseases of the eye and adnexa
0.959 0.041 0.000
M15-M19 Arthrosis
0.955 0.045 0.000
R10-R19 Symptoms and signs involving the digestive system and abdomen
0.954 0.046 0.000
K13.7 Other and unspecified lesions of oral mucosa
0.951 0.049 0.000
M17 Gonarthrosis [arthrosis of knee]
0.949 0.051 0.000
R11 Nausea and vomiting
0.946 0.054 0.000
M17.9 Gonarthrosis, unspecified
0.944 0.056 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.941 0.059 0.000
M50-M54 Other dorsopathies
0.940 0.060 0.000
Chapter XX External causes of morbidity and mortality
0.932 0.068 0.000
Chapter VIII Diseases of the ear and mastoid process
0.931 0.069 0.000
M23 Internal derangement of knee
0.927 0.073 0.000
G90-G99 Other disorders of the nervous system
0.920 0.080 0.000
E11.5 With peripheral circulatory complications
0.919 0.081 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.913 0.087 0.000
M22 Disorders of patella
0.909 0.091 0.000
E11.4 With neurological complications
0.906 0.094 0.000
E10 Insulin-dependent diabetes mellitus
0.904 0.095 0.000
K70-K77 Diseases of liver
0.896 0.104 0.000
E70-E90 Metabolic disorders
0.892 0.108 0.000
R07 Pain in throat and chest
0.890 0.110 0.000
F41.2 Mixed anxiety and depressive disorder
0.888 0.112 0.000
O26 Maternal care for other conditions predominantly related to pregnancy
0.887 0.113 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.886 0.114 0.000
R06 Abnormalities of breathing
0.883 0.117 0.000
S80-S89 Injuries to the knee and lower leg
0.879 0.121 0.000
M45-M49 Spondylopathies
0.877 0.123 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.876 0.124 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.876 0.124 0.000
O60-O75 Complications of labour and delivery
0.874 0.126 0.000
M54 Dorsalgia
0.871 0.129 0.000
E14 Unspecified diabetes mellitus
0.869 0.131 0.000
R10 Abdominal and pelvic pain
0.863 0.137 0.000
M65-M68 Disorders of synovium and tendon
0.863 0.137 0.000
E86 Volume depletion
0.861 0.139 0.000
R07.2 Precordial pain
0.860 0.140 0.000
K65-K67 Diseases of peritoneum
0.858 0.142 0.000
M23.2 Derangement of meniscus due to old tear or injury
0.858 0.142 0.000
K05 Gingivitis and periodontal diseases
0.854 0.146 0.000
Chapter IX Diseases of the circulatory system
0.852 0.148 0.000
K08 Other disorders of teeth and supporting structures
0.847 0.153 0.000
O26.8 Other specified pregnancy-related conditions
0.847 0.153 0.000
H00 Hordeolum and chalazion
0.843 0.157 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.842 0.158 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.841 0.159 0.000
K02 Dental caries
0.838 0.162 0.000
K81 Cholecystitis
0.836 0.164 0.000
H65-H75 Diseases of middle ear and mastoid
0.835 0.165 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.830 0.170 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.826 0.174 0.000
M22.4 Chondromalacia patellae
0.824 0.176 0.000
M25 Other joint disorders, not elsewhere classified
0.824 0.176 0.000
M17.0 Primary gonarthrosis, bilateral
0.820 0.180 0.000
M48 Other spondylopathies
0.815 0.184 0.000
M23.23 Derangement of meniscus due to old tear or injury (Medial collateral ligament or Other and unspecified medial meniscus)
0.815 0.185 0.000
R02 Gangrene, not elsewhere classified
0.813 0.187 0.000
K76 Other diseases of liver
0.813 0.187 0.000
H00.1 Chalazion
0.813 0.187 0.000
E10.9 Without complications
0.812 0.188 0.000
R06.0 Dyspnoea
0.812 0.188 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.811 0.189 0.000
M54.9 Dorsalgia, unspecified
0.811 0.189 0.000
E11.3 With ophthalmic complications
0.809 0.191 0.000
K85 Acute pancreatitis
0.805 0.195 0.000
S20-S29 Injuries to the thorax
0.803 0.197 0.000
K07 Dentofacial anomalies [including malocclusion]
0.802 0.198 0.000
M24 Other specific joint derangements
0.802 0.198 0.000
K80.0 Calculus of gallbladder with acute cholecystitis
0.801 0.199 0.000
R42 Dizziness and giddiness
0.795 0.205 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.788 0.212 0.000
G99 Other disorders of nervous system in diseases classified elsewhere
0.786 0.214 0.000
F99-F99 Unspecified mental disorder
0.784 0.216 0.000
K86 Other diseases of pancreas
0.784 0.216 0.000
H43-H45 Disorders of vitreous body and globe
0.782 0.218 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.782 0.218 0.000
I30-I52 Other forms of heart disease
0.782 0.218 0.000
K11 Diseases of salivary glands
0.782 0.218 0.000
R00 Abnormalities of heart beat
0.781 0.219 0.000
R10.1 Pain localised to upper abdomen
0.780 0.220 0.000
M65 Synovitis and tenosynovitis
0.779 0.221 0.000
S50-S59 Injuries to the elbow and forearm
0.778 0.221 0.000
G20-G26 Extrapyramidal and movement disorders
0.778 0.221 0.000
E14.9 Without complications
0.777 0.223 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.774 0.225 0.000
F40 Phobic anxiety disorders
0.773 0.227 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.772 0.228 0.000
E20-E35 Disorders of other endocrine glands
0.772 0.228 0.000
M48.0 Spinal stenosis
0.772 0.228 0.000
K12 Stomatitis and related lesions
0.771 0.228 0.000
M35 Other systemic involvement of connective tissue
0.769 0.231 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.768 0.232 0.000
R01 Cardiac murmurs and other cardiac sounds
0.767 0.233 0.000
H90-H95 Other disorders of ear
0.766 0.234 0.000
G40-G47 Episodic and paroxysmal disorders
0.766 0.234 0.000
O72 Postpartum haemorrhage
0.765 0.235 0.000
S82 Fracture of lower leg, including ankle
0.765 0.235 0.000
E65-E68 Obesity and other hyperalimentation
0.763 0.237 0.000
K80.4 Calculus of bile duct with cholecystitis
0.763 0.237 0.000
V20-V29 Motorcycle rider injured in transport accident
0.762 0.238 0.000
M23.8 Other internal derangements of knee
0.761 0.239 0.000
Chapter XXII Codes for special purposes
0.761 0.239 0.000
G93 Other disorders of brain
0.760 0.240 0.000
K01 Embedded and impacted teeth
0.760 0.240 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.759 0.241 0.000
K35-K38 Diseases of appendix
0.757 0.243 0.000
Y40 Systemic antibiotics
0.757 0.243 0.000
H53-H54 Visual disturbances and blindness
0.757 0.243 0.000
K10 Other diseases of jaws
0.757 0.243 0.000
K82 Other diseases of gallbladder
0.757 0.243 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.755 0.245 0.000
K81.9 Cholecystitis, unspecified
0.753 0.247 0.000
S90-S99 Injuries to the ankle and foot
0.753 0.247 0.000
H10-H13 Disorders of conjunctiva
0.752 0.248 0.000
M54.99 Dorsalgia, unspecified (Site unspecified)
0.750 0.250 0.000
K08.3 Retained dental root
0.749 0.251 0.000
R10.4 Other and unspecified abdominal pain
0.749 0.251 0.000
M51 Other intervertebral disk disorders
0.749 0.251 0.000
G95 Other diseases of spinal cord
0.748 0.251 0.000
R40 Somnolence, stupor and coma
0.747 0.253 0.000
M22.8 Other disorders of patella
0.747 0.253 0.000
O24 Diabetes mellitus in pregnancy
0.747 0.253 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.747 0.253 0.000
K04 Diseases of pulp and periapical tissues
0.746 0.254 0.000
M23.20 Derangement of meniscus due to old tear or injury (Multiple sites)
0.745 0.255 0.000
H40-H42 Glaucoma
0.745 0.255 0.000
K13.0 Diseases of lips
0.743 0.257 0.000
O80-O84 Delivery
0.737 0.263 0.000
R17 Unspecified jaundice
0.737 0.263 0.000
S32 Fracture of lumbar spine and pelvis
0.737 0.263 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.736 0.264 0.000
G62 Other polyneuropathies
0.736 0.264 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.736 0.264 0.000
R05 Cough
0.735 0.265 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.734 0.266 0.000
M40-M43 Deforming dorsopathies
0.734 0.266 0.000
H01 Other inflammation of eyelid
0.734 0.266 0.000
O21 Excessive vomiting in pregnancy
0.733 0.267 0.000
M80-M85 Disorders of bone density and structure
0.733 0.267 0.000
F45 Somatoform disorders
0.732 0.268 0.000
E83 Disorders of mineral metabolism
0.729 0.271 0.000
I49 Other cardiac arrhythmias
0.728 0.272 0.000
M86-M90 Other osteopathies
0.727 0.273 0.000
R45 Symptoms and signs involving emotional state
0.725 0.275 0.000
H52 Disorders of refraction and accommodation
0.725 0.275 0.000
K02.9 Dental caries, unspecified
0.723 0.277 0.000
T66-T78 Other and unspecified effects of external causes
0.719 0.281 0.000
K80.3 Calculus of bile duct with cholangitis
0.717 0.283 0.000
K80.8 Other cholelithiasis
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
K87 Disorders of gallbladder, biliary tract and pancreas in diseases classified elsewhere
0.717 0.283 0.000
E13 Other specified diabetes mellitus
0.717 0.283 0.000
E12 Malnutrition-related diabetes mellitus
0.717 0.283 0.000
E40-E46 Malnutrition
0.717 0.283 0.000
E11.8 With unspecified complications
0.717 0.283 0.000
E11.7 With multiple complications
0.717 0.283 0.000
E11.6 With other specified complications
0.717 0.283 0.000
E11.2 With renal complications
0.717 0.283 0.000
E11.1 With ketoacidosis
0.717 0.283 0.000
E11.0 With coma
0.717 0.283 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.717 0.283 0.000
M91-M94 Chondropathies
0.717 0.283 0.000
M60-M63 Disorders of muscles
0.717 0.283 0.000
M00-M03 Infectious arthropathies
0.717 0.283 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.716 0.284 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.716 0.284 0.000
K09 Cysts of oral region, not elsewhere classified
0.716 0.284 0.000
K06 Other disorders of gingiva and edentulous alveolar ridge
0.716 0.284 0.000
K03 Other diseases of hard tissues of teeth
0.716 0.284 0.000
K00 Disorders of tooth development and eruption
0.716 0.284 0.000
K76.0 Fatty (change of) liver, not elsewhere classified
0.714 0.286 0.000
Y43 Primarily systemic agents
0.713 0.287 0.000
R06.8 Other and unspecified abnormalities of breathing
0.712 0.288 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.711 0.289 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.710 0.290 0.000
F80-F89 Disorders of psychological development
0.710 0.290 0.000
F70-F79 Mental retardation
0.710 0.290 0.000
F60-F69 Disorders of adult personality and behaviour
0.710 0.290 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.710 0.290 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.709 0.291 0.000
F48 Other neurotic disorders
0.708 0.292 0.000
F44 Dissociative [conversion] disorders
0.708 0.292 0.000
F43 Reaction to severe stress, and adjustment disorders
0.708 0.292 0.000
F42 Obsessive-compulsive disorder
0.708 0.292 0.000
G30-G32 Other degenerative diseases of the nervous system
0.708 0.292 0.000
G70-G73 Diseases of myoneural junction and muscle
0.707 0.293 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.707 0.293 0.000
H80-H83 Diseases of inner ear
0.707 0.293 0.000
M50 Cervical disk disorders
0.707 0.293 0.000
S70-S79 Injuries to the hip and thigh
0.706 0.294 0.000
F41.8 Other specified anxiety disorders
0.706 0.294 0.000
F41.3 Other mixed anxiety disorders
0.706 0.294 0.000
F41.1 Generalised anxiety disorder
0.706 0.294 0.000
K66 Other disorders of peritoneum
0.706 0.294 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.705 0.295 0.000
M34 Systemic sclerosis
0.705 0.295 0.000
M33 Dermatopolymyositis
0.705 0.295 0.000
M32 Systemic lupus erythematosus
0.705 0.295 0.000
M31 Other necrotising vasculopathies
0.705 0.295 0.000
M30 Polyarteritis nodosa and related conditions
0.705 0.295 0.000
M21 Other acquired deformities of limbs
0.705 0.295 0.000
T79-T79 Certain early complications of trauma
0.705 0.295 0.000
T33-T35 Frostbite
0.705 0.295 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.705 0.295 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.705 0.295 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.705 0.295 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.705 0.295 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.705 0.295 0.000
T00-T07 Injuries involving multiple body regions
0.705 0.295 0.000
S10-S19 Injuries to the neck
0.705 0.295 0.000
O63 Long labour
0.705 0.295 0.000
O85-O92 Complications predominantly related to the puerperium
0.705 0.295 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.704 0.296 0.000
O62 Abnormalities of forces of labour
0.699 0.301 0.000
K05.3 Chronic periodontitis
0.698 0.302 0.000
O75 Other complications of labour and delivery, not elsewhere classified
0.698 0.302 0.000
K13.2 Leukoplakia and other disturbances of oral epithelium, including tongue
0.697 0.303 0.000
K13.6 Irritative hyperplasia of oral mucosa
0.697 0.303 0.000
K13.5 Oral submucous fibrosis
0.697 0.303 0.000
K13.4 Granuloma and granuloma-like lesions of oral mucosa
0.697 0.303 0.000
K13.3 Hairy leukoplakia
0.697 0.303 0.000
K13.1 Cheek and lip biting
0.697 0.303 0.000
K65 Peritonitis
0.697 0.303 0.000
R09 Other symptoms and signs involving the circulatory and respiratory systems
0.696 0.304 0.000
K83 Other diseases of biliary tract
0.695 0.305 0.000
K05.6 Periodontal disease, unspecified
0.694 0.306 0.000
K76.8 Other specified diseases of liver
0.694 0.306 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.693 0.307 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.691 0.309 0.000
G91 Hydrocephalus
0.690 0.309 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.690 0.310 0.000
G99.2 Myelopathy in diseases classified elsewhere
0.689 0.310 0.000
E10.1 With ketoacidosis
0.689 0.311 0.000
K70 Alcoholic liver disease
0.688 0.311 0.000
S40-S49 Injuries to the shoulder and upper arm
0.688 0.312 0.000
H55-H59 Other disorders of eye and adnexa
0.688 0.312 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.688 0.312 0.000
R00.1 Bradycardia, unspecified
0.688 0.312 0.000
M23.29 Derangement of meniscus due to old tear or injury (Unspecified ligament or Unspecified meniscus)
0.687 0.313 0.000
G50 Disorders of trigeminal nerve
0.687 0.313 0.000
M23.3 Other meniscus derangements
0.687 0.313 0.000
O72.1 Other immediate postpartum haemorrhage
0.687 0.313 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.686 0.314 0.000
R13 Dysphagia
0.685 0.315 0.000
M15 Polyarthrosis
0.684 0.315 0.000
H66 Suppurative and unspecified otitis media
0.684 0.316 0.000
R14 Flatulence and related conditions
0.684 0.316 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.682 0.318 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.681 0.319 0.000
S89 Other and unspecified injuries of lower leg
0.681 0.319 0.000
M17.5 Other secondary gonarthrosis
0.680 0.319 0.000
M17.4 Other secondary gonarthrosis, bilateral
0.680 0.319 0.000
M17.3 Other posttraumatic gonarthrosis
0.680 0.319 0.000
M17.2 Posttraumatic gonarthrosis, bilateral
0.680 0.319 0.000
R07.4 Chest pain, unspecified
0.681 0.319 0.000
M65.9 Synovitis and tenosynovitis, unspecified
0.680 0.320 0.000
G59 Mononeuropathy in diseases classified elsewhere
0.680 0.320 0.000
V10-V19 Pedal cyclist injured in transport accident
0.679 0.321 0.000
H60-H62 Diseases of external ear
0.679 0.321 0.000
E10.3 With ophthalmic complications
0.678 0.321 0.000
O20 Haemorrhage in early pregnancy
0.678 0.322 0.000
W20-W49 Exposure to inanimate mechanical forces
0.677 0.323 0.000
O00-O08 Pregnancy with abortive outcome
0.676 0.324 0.000
S82.8 Fractures of other parts of lower leg
0.676 0.324 0.000
O29 Complications of anaesthesia during pregnancy
0.674 0.325 0.000
O28 Abnormal findings on antenatal screening of mother
0.674 0.325 0.000
O23 Infections of genito-urinary tract in pregnancy
0.674 0.325 0.000
O22 Venous complications in pregnancy
0.674 0.325 0.000
O25 Malnutrition in pregnancy
0.674 0.325 0.000
R04 Haemorrhage from respiratory passages
0.674 0.326 0.000
M53 Other dorsopathies, not elsewhere classified
0.674 0.326 0.000
Y40.0 Penicillins
0.672 0.328 0.000
M48.06 Spinal stenosis (Lumbar region)
0.672 0.328 0.000
S81 Open wound of lower leg
0.672 0.328 0.000
M24.1 Other articular cartilage disorders
0.672 0.328 0.000
T91 Sequelae of injuries of neck and trunk
0.670 0.329 0.000
R93 Abnormal findings on diagnostic imaging of other body structures
0.670 0.330 0.000
Y44 Agents primarily affecting blood constituents
0.669 0.331 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.668 0.332 0.000
Y35-Y36 Legal intervention and operations of war
0.668 0.332 0.000
Y10-Y34 Event of undetermined intent
0.668 0.332 0.000
Y00-Y09 Assault
0.668 0.332 0.000
X85-X99 Assault
0.668 0.332 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.668 0.332 0.000
X50-X57 Overexertion, travel and privation
0.668 0.332 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.668 0.332 0.000
X30-X39 Exposure to forces of nature
0.668 0.332 0.000
X20-X29 Contact with venomous animals and plants
0.668 0.332 0.000
X10-X19 Contact with heat and hot substances
0.668 0.332 0.000
X00-X09 Exposure to smoke, fire and flames
0.668 0.332 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.668 0.332 0.000
W75-W84 Other accidental threats to breathing
0.668 0.332 0.000
W65-W74 Accidental drowning and submersion
0.668 0.332 0.000
W50-W64 Exposure to animate mechanical forces
0.668 0.332 0.000
V98-V99 Other and unspecified transport accidents
0.668 0.332 0.000
V95-V97 Air and space transport accidents
0.668 0.332 0.000
V90-V94 Water transport accidents
0.668 0.332 0.000
V80-V89 Other land transport accidents
0.668 0.332 0.000
V70-V79 Bus occupant injured in transport accident
0.668 0.332 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.668 0.332 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.668 0.332 0.000
V40-V49 Car occupant injured in transport accident
0.668 0.332 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.668 0.332 0.000
V01-V09 Pedestrian injured in transport accident
0.668 0.332 0.000
M54.5 Low back pain
0.668 0.332 0.000
X60-X84 Intentional self-harm
0.667 0.333 0.000
G25 Other extrapyramidal and movement disorders
0.666 0.334 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.666 0.334 0.000
H54 Blindness and low vision
0.666 0.334 0.000
M23.9 Internal derangement of knee, unspecified
0.665 0.335 0.000
M23.6 Other spontaneous disruption of ligament(s) of knee
0.665 0.335 0.000
M23.5 Chronic instability of knee
0.665 0.335 0.000
M23.4 Loose body in knee
0.665 0.335 0.000
M23.1 Discoid meniscus (congenital)
0.665 0.335 0.000
M23.0 Cystic meniscus
0.665 0.335 0.000
K85.1 Biliary acute pancreatitis
0.665 0.335 0.000
R10.3 Pain localised to other parts of lower abdomen
0.664 0.336 0.000
T90 Sequelae of injuries of head
0.663 0.337 0.000
S60-S69 Injuries to the wrist and hand
0.663 0.337 0.000
H65 Nonsuppurative otitis media
0.660 0.340 0.000
E50-E64 Other nutritional deficiencies
0.659 0.341 0.000
M54.4 Lumbago with sciatica
0.659 0.341 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.659 0.341 0.000
G96 Other disorders of central nervous system
0.659 0.341 0.000
G94 Other disorders of brain in diseases classified elsewhere
0.659 0.341 0.000
G90 Disorders of autonomic nervous system
0.659 0.341 0.000
G98 Other disorders of nervous system, not elsewhere classified
0.659 0.341 0.000
G92 Toxic encephalopathy
0.659 0.341 0.000
I45 Other conduction disorders
0.659 0.341 0.000
R16 Hepatomegaly and splenomegaly, not elsewhere classified
0.658 0.341 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.658 0.342 0.000
M25.9 Joint disorder, unspecified
0.658 0.342 0.000
M46 Other inflammatory spondylopathies
0.657 0.343 0.000
K72 Hepatic failure, not elsewhere classified
0.656 0.344 0.000
T93 Sequelae of injuries of lower limb
0.656 0.344 0.000
R46 Symptoms and signs involving appearance and behaviour
0.655 0.345 0.000
R43 Disturbances of smell and taste
0.655 0.345 0.000
H43 Disorders of vitreous body
0.653 0.347 0.000
M22.1 Recurrent subluxation of patella
0.652 0.348 0.000
M22.9 Disorder of patella, unspecified
0.652 0.348 0.000
M22.3 Other derangements of patella
0.652 0.348 0.000
M22.2 Patellofemoral disorders
0.652 0.348 0.000
M22.0 Recurrent dislocation of patella
0.652 0.348 0.000
O66 Other obstructed labour
0.649 0.351 0.000
O46 Antepartum haemorrhage, not elsewhere classified
0.649 0.351 0.000
M54.96 Dorsalgia, unspecified (Lumbar region)
0.649 0.351 0.000
O64 Obstructed labour due to malposition and malpresentation of foetus
0.649 0.351 0.000
E10.8 With unspecified complications
0.648 0.351 0.000
E10.7 With multiple complications
0.648 0.351 0.000
E10.6 With other specified complications
0.648 0.351 0.000
E10.5 With peripheral circulatory complications
0.648 0.351 0.000
E10.4 With neurological complications
0.648 0.351 0.000
E10.2 With renal complications
0.648 0.351 0.000
E10.0 With coma
0.648 0.351 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.648 0.352 0.000
M65.3 Trigger finger
0.648 0.352 0.000
H73 Other disorders of tympanic membrane
0.647 0.353 0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee
0.646 0.354 0.000
G93.3 Postviral fatigue syndrome
0.646 0.354 0.000
I05-I09 Chronic rheumatic heart diseases
0.645 0.355 0.000
O26.9 Pregnancy-related condition, unspecified
0.645 0.355 0.000
G56 Mononeuropathies of upper limb
0.645 0.355 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.644 0.356 0.000
H90 Conductive and sensorineural hearing loss
0.643 0.357 0.000
I49.4 Other and unspecified premature depolarisation
0.643 0.357 0.000
K77 Liver disorders in diseases classified elsewhere
0.642 0.357 0.000
K75 Other inflammatory liver diseases
0.642 0.357 0.000
K73 Chronic hepatitis, not elsewhere classified
0.642 0.357 0.000
K71 Toxic liver disease
0.642 0.357 0.000
M23.25 Derangement of meniscus due to old tear or injury (Posterior horn of lateral meniscus)
0.641 0.359 0.000
V23 Motorcycle rider injured in collision with car, pick-up truck or van
0.640 0.360 0.000
E88 Other metabolic disorders
0.640 0.360 0.000
E85 Amyloidosis
0.640 0.360 0.000
E84 Cystic fibrosis
0.640 0.360 0.000
E79 Disorders of purine and pyrimidine metabolism
0.640 0.360 0.000
E77 Disorders of glycoprotein metabolism
0.640 0.360 0.000
E76 Disorders of glycosaminoglycan metabolism
0.640 0.360 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.640 0.360 0.000
E74 Other disorders of carbohydrate metabolism
0.640 0.360 0.000
E73 Lactose intolerance
0.640 0.360 0.000
E72 Other disorders of amino-acid metabolism
0.640 0.360 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.640 0.360 0.000
E70 Disorders of aromatic amino-acid metabolism
0.640 0.360 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.640 0.360 0.000
H71 Cholesteatoma of middle ear
0.639 0.361 0.000
O69 Labour and delivery complicated by umbilical cord complications
0.638 0.362 0.000
K11.2 Sialoadenitis
0.638 0.362 0.000
R07.1 Chest pain on breathing
0.638 0.362 0.000
Chapter I Certain infectious and parasitic diseases
0.638 0.362 0.000
M48.09 Spinal stenosis (Site unspecified)
0.637 0.363 0.000
E16 Other disorders of pancreatic internal secretion
0.637 0.363 0.000
O26.7 Subluxation of symphysis (pubis) in pregnancy, childbirth and the puerperium
0.636 0.364 0.000
O26.6 Liver disorders in pregnancy, childbirth and the puerperium
0.636 0.364 0.000
O26.5 Maternal hypotension syndrome
0.636 0.364 0.000
O26.4 Herpes gestationis
0.636 0.364 0.000
O26.3 Retained intra-uterine contraceptive device in pregnancy
0.636 0.364 0.000
O26.2 Pregnancy care of habitual aborter
0.636 0.364 0.000
O26.1 Low weight gain in pregnancy
0.636 0.364 0.000
O26.0 Excessive weight gain in pregnancy
0.636 0.364 0.000
F99 Mental disorder, not otherwise specified
0.635 0.364 0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.635 0.365 0.000
H05 Disorders of orbit
0.635 0.365 0.000
H03 Disorders of eyelid in diseases classified elsewhere
0.635 0.365 0.000
G62.9 Polyneuropathy, unspecified
0.635 0.365 0.000
G63.2 Diabetic polyneuropathy
0.635 0.365 0.000
Y86 Sequelae of other accidents
0.635 0.365 0.000
G40 Epilepsy
0.635 0.365 0.000
K14 Diseases of tongue
0.635 0.365 0.000
I10-I15 Hypertensive diseases
0.634 0.366 0.000
T84.0 Mechanical complication of internal joint prosthesis
0.633 0.367 0.000
I31 Other diseases of pericardium
0.633 0.367 0.000
M23.89 Other internal derangements of knee (Unspecified ligament or Unspecified meniscus)
0.633 0.367 0.000
R06.7 Sneezing
0.633 0.367 0.000
R06.6 Hiccough
0.633 0.367 0.000
R06.4 Hyperventilation
0.633 0.367 0.000
R06.3 Periodic breathing
0.633 0.367 0.000
R06.2 Wheezing
0.633 0.367 0.000
R06.1 Stridor
0.633 0.367 0.000
S22 Fracture of rib(s), sternum and thoracic spine
0.633 0.367 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.632 0.368 0.000
S52 Fracture of forearm
0.632 0.368 0.000
H52.1 Myopia
0.631 0.369 0.000
K07.6 Temporomandibular joint disorders
0.631 0.369 0.000
S88 Traumatic amputation of lower leg
0.630 0.370 0.000
S87 Crushing injury of lower leg
0.630 0.370 0.000
S86 Injury of muscle and tendon at lower leg level
0.630 0.370 0.000
S85 Injury of blood vessels at lower leg level
0.630 0.370 0.000
S84 Injury of nerves at lower leg level
0.630 0.370 0.000
S27 Injury of other and unspecified intrathoracic organs
0.630 0.370 0.000
M49 Spondylopathies in diseases classified elsewhere
0.629 0.371 0.000
R40.2 Coma, unspecified
0.629 0.371 0.000
Y59 Other and unspecified vaccines and biological substances
0.628 0.372 0.000
Y58 Bacterial vaccines
0.628 0.372 0.000
Y57 Other and unspecified drugs and medicaments
0.628 0.372 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.628 0.372 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.628 0.372 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.628 0.372 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.628 0.372 0.000
Y52 Agents primarily affecting the cardiovascular system
0.628 0.372 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.628 0.372 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.628 0.372 0.000
Y48 Anaesthetics and therapeutic gases
0.628 0.372 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.628 0.372 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.628 0.372 0.000
M25.5 Pain in joint
0.628 0.372 0.000
G61 Inflammatory polyneuropathy
0.628 0.372 0.000
G60 Hereditary and idiopathic neuropathy
0.628 0.372 0.000
G64 Other disorders of peripheral nervous system
0.628 0.372 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.628 0.372 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.628 0.372 0.000
M51.0 Lumbar and other intervertebral disk disorders with myelopathy
0.627 0.372 0.000
M48.07 Spinal stenosis (Lumbosacral region)
0.627 0.373 0.000
O74 Complications of anaesthesia during labour and delivery
0.626 0.374 0.000
O73 Retained placenta and membranes, without haemorrhage
0.626 0.374 0.000
O71 Other obstetric trauma
0.626 0.374 0.000
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified
0.626 0.374 0.000
O65 Obstructed labour due to maternal pelvic abnormality
0.626 0.374 0.000
O61 Failed induction of labour
0.626 0.374 0.000
O60 Preterm delivery
0.626 0.374 0.000
M45 Ankylosing spondylitis
0.626 0.374 0.000
G95.2 Cord compression, unspecified
0.626 0.374 0.000
K86.3 Pseudocyst of pancreas
0.625 0.375 0.000
K81.0 Acute cholecystitis
0.625 0.375 0.000
H01.0 Blepharitis
0.625 0.375 0.000
M54.8 Other dorsalgia
0.625 0.375 0.000
M54.6 Pain in thoracic spine
0.625 0.375 0.000
M54.0 Panniculitis affecting regions of neck and back
0.625 0.375 0.000
E14.8 With unspecified complications
0.623 0.377 0.000
E14.7 With multiple complications
0.623 0.377 0.000
E14.6 With other specified complications
0.623 0.377 0.000
E14.5 With peripheral circulatory complications
0.623 0.377 0.000
E14.4 With neurological complications
0.623 0.377 0.000
E14.2 Withrenal complications
0.623 0.377 0.000
E14.1 With ketoacidosis
0.623 0.377 0.000
E14.0 With coma
0.623 0.377 0.000
G12 Spinal muscular atrophy and related syndromes
0.623 0.377 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.622 0.377 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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