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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs76287751
log Bayes Factor = 15.4167
Chromosome 21   position 22,696,657  (GRCh37) Explore rs76287751 on Ensembl!
Variant rs76287751 is part of Cluster X0083

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
I20-I25 Ischaemic heart diseases
1.000 0.000 0.000
E66 Obesity
1.000 0.000 0.000
I25 Chronic ischaemic heart disease
1.000 0.000 0.000
E65-E68 Obesity and other hyperalimentation
0.999 0.001 0.000
I30-I52 Other forms of heart disease
0.999 0.001 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.999 0.001 0.000
E66.9 Obesity, unspecified
0.999 0.001 0.000
Chapter XX External causes of morbidity and mortality
0.997 0.003 0.000
M20-M25 Other joint disorders
0.996 0.004 0.000
E66.8 Other obesity
0.996 0.004 0.000
M70-M79 Other soft tissue disorders
0.995 0.005 0.000
Chapter V Mental and behavioural disorders
0.994 0.006 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.993 0.007 0.000
Chapter VI Diseases of the nervous system
0.992 0.008 0.000
I25.8 Other forms of chronic ischaemic heart disease
0.990 0.010 0.000
I50 Heart failure
0.987 0.013 0.000
M75 Shoulder lesions
0.985 0.015 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.980 0.020 0.000
I25.2 Old myocardial infarction
0.976 0.024 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.973 0.027 0.000
M25 Other joint disorders, not elsewhere classified
0.972 0.028 0.000
M24 Other specific joint derangements
0.970 0.030 0.000
F41 Other anxiety disorders
0.967 0.033 0.000
I50.9 Heart failure, unspecified
0.963 0.037 0.000
F41.0 Panic disorder [episodic paroxysmal anxiety]
0.953 0.047 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.950 0.050 0.000
S40-S49 Injuries to the shoulder and upper arm
0.943 0.057 0.000
M75.4 Impingement syndrome of shoulder
0.943 0.057 0.000
M40-M43 Deforming dorsopathies
0.941 0.059 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.939 0.061 0.000
M75.1 Rotator cuff syndrome
0.937 0.063 0.000
I35 Nonrheumatic aortic valve disorders
0.936 0.064 0.000
G56 Mononeuropathies of upper limb
0.935 0.065 0.000
G90-G99 Other disorders of the nervous system
0.935 0.065 0.000
I73 Other peripheral vascular diseases
0.933 0.067 0.000
I34 Nonrheumatic mitral valve disorders
0.933 0.067 0.000
M45-M49 Spondylopathies
0.930 0.070 0.000
M15-M19 Arthrosis
0.930 0.070 0.000
G56.0 Carpal tunnel syndrome
0.929 0.071 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.924 0.076 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.913 0.087 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.913 0.087 0.000
I72 Other aneurysm
0.908 0.092 0.000
M24.1 Other articular cartilage disorders
0.905 0.095 0.000
I21 Acute myocardial infarction
0.904 0.096 0.000
S20-S29 Injuries to the thorax
0.898 0.102 0.000
E10-E14 Diabetes mellitus
0.897 0.103 0.000
F80-F89 Disorders of psychological development
0.894 0.106 0.000
I73.0 Raynaud's syndrome
0.889 0.111 0.000
I50.1 Left ventricular failure
0.889 0.111 0.000
F41.2 Mixed anxiety and depressive disorder
0.889 0.111 0.000
I34.0 Mitral (valve) insufficiency
0.886 0.114 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.881 0.119 0.000
I20 Angina pectoris
0.881 0.119 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.879 0.121 0.000
I22 Subsequent myocardial infarction
0.877 0.123 0.000
I25.4 Coronary artery aneurysm
0.876 0.124 0.000
I21.4 Acute subendocardial myocardial infarction
0.875 0.125 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.874 0.126 0.000
I31 Other diseases of pericardium
0.873 0.127 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.873 0.127 0.000
I51 Complications and ill-defined descriptions of heart disease
0.873 0.127 0.000
M18 Arthrosis of first carpometacarpal joint
0.873 0.127 0.000
M19 Other arthrosis
0.872 0.128 0.000
Y86 Sequelae of other accidents
0.871 0.129 0.000
M65-M68 Disorders of synovium and tendon
0.867 0.133 0.000
I05-I09 Chronic rheumatic heart diseases
0.867 0.133 0.000
M41 Scoliosis
0.865 0.135 0.000
I20.9 Angina pectoris, unspecified
0.861 0.139 0.000
M25.7 Osteophyte
0.860 0.140 0.000
I35.0 Aortic (valve) stenosis
0.859 0.141 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.852 0.148 0.000
M19.9 Arthrosis, unspecified
0.852 0.148 0.000
S42 Fracture of shoulder and upper arm
0.844 0.156 0.000
Y57 Other and unspecified drugs and medicaments
0.844 0.156 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.842 0.158 0.000
S30 Superficial injury of abdomen, lower back and pelvis
0.841 0.159 0.000
I25.5 Ischaemic cardiomyopathy
0.840 0.160 0.000
M19.99 Arthrosis, unspecified (Site unspecified)
0.837 0.163 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.832 0.168 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.830 0.170 0.000
M18.9 Arthrosis of first carpometacarpal joint, unspecified
0.830 0.170 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.828 0.172 0.000
F30-F39 Mood [affective] disorders
0.828 0.172 0.000
S40 Superficial injury of shoulder and upper arm
0.827 0.173 0.000
T51 Toxic effect of alcohol
0.827 0.173 0.000
I44 Atrioventricular and left bundle-branch block
0.827 0.173 0.000
M75.2 Bicipital tendinitis
0.820 0.180 0.000
M34 Systemic sclerosis
0.816 0.184 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.816 0.184 0.000
I70 Atherosclerosis
0.815 0.185 0.000
M22 Disorders of patella
0.814 0.186 0.000
F81 Specific developmental disorders of scholastic skills
0.811 0.189 0.000
M41.9 Scoliosis, unspecified
0.811 0.189 0.000
I25.3 Aneurysm of heart
0.810 0.190 0.000
M25.4 Effusion of joint
0.809 0.191 0.000
G93 Other disorders of brain
0.809 0.191 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.808 0.192 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.807 0.193 0.000
I30 Acute pericarditis
0.807 0.193 0.000
M23 Internal derangement of knee
0.805 0.195 0.000
M46 Other inflammatory spondylopathies
0.805 0.195 0.000
M24.11 Other articular cartilage disorders (Shoulder region)
0.801 0.199 0.000
G30-G32 Other degenerative diseases of the nervous system
0.798 0.202 0.000
M75.9 Shoulder lesion, unspecified
0.797 0.203 0.000
I44.7 Left bundle-branch block, unspecified
0.796 0.204 0.000
R93 Abnormal findings on diagnostic imaging of other body structures
0.796 0.204 0.000
M76 Enthesopathies of lower limb, excluding foot
0.796 0.204 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.795 0.205 0.000
M77 Other enthesopathies
0.794 0.206 0.000
I72.4 Aneurysm of artery of lower extremity
0.793 0.207 0.000
W20-W49 Exposure to inanimate mechanical forces
0.792 0.208 0.000
M43 Other deforming dorsopathies
0.791 0.209 0.000
G20-G26 Extrapyramidal and movement disorders
0.790 0.210 0.000
M25.8 Other specified joint disorders
0.790 0.210 0.000
R21 Rash and other nonspecific skin eruption
0.789 0.211 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.788 0.212 0.000
Y95 Nosocomial condition
0.786 0.214 0.000
Y60 Unintentional cut, puncture, perforation or haemorrhage during surgical and medical care
0.784 0.216 0.000
M41.96 Scoliosis, unspecified (Lumbar region)
0.784 0.216 0.000
I31.3 Pericardial effusion (noninflammatory)
0.780 0.220 0.000
S10-S19 Injuries to the neck
0.780 0.220 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.780 0.220 0.000
I35.2 Aortic (valve) stenosis with insufficiency
0.778 0.222 0.000
S22 Fracture of rib(s), sternum and thoracic spine
0.777 0.223 0.000
Y57.9 Drug or medicament, unspecified
0.776 0.224 0.000
S30.8 Other superficial injuries of abdomen, lower back and pelvis
0.775 0.225 0.000
I36 Nonrheumatic tricuspid valve disorders
0.773 0.227 0.000
G59 Mononeuropathy in diseases classified elsewhere
0.772 0.227 0.000
R93.3 Abnormal findings on diagnostic imaging of other parts of digestive tract
0.772 0.228 0.000
E10 Insulin-dependent diabetes mellitus
0.771 0.229 0.000
X60-X84 Intentional self-harm
0.766 0.234 0.000
M71 Other bursopathies
0.766 0.234 0.000
M24.16 Other articular cartilage disorders (Lower leg)
0.766 0.234 0.000
V80-V89 Other land transport accidents
0.764 0.236 0.000
M19.90 Arthrosis, unspecified (Multiple sites)
0.763 0.237 0.000
M25.5 Pain in joint
0.762 0.238 0.000
R91 Abnormal findings on diagnostic imaging of lung
0.762 0.238 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.762 0.238 0.000
S21 Open wound of thorax
0.761 0.238 0.000
G95 Other diseases of spinal cord
0.761 0.239 0.000
Y40 Systemic antibiotics
0.760 0.240 0.000
Y43 Primarily systemic agents
0.757 0.243 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.757 0.243 0.000
M60-M63 Disorders of muscles
0.756 0.243 0.000
I25.1 Atherosclerotic heart disease
0.755 0.245 0.000
F81.9 Developmental disorder of scholastic skills, unspecified
0.752 0.248 0.000
G51 Facial nerve disorders
0.751 0.249 0.000
F03 Unspecified dementia
0.751 0.249 0.000
T79-T79 Certain early complications of trauma
0.750 0.250 0.000
S46 Injury of muscle and tendon at shoulder and upper arm level
0.748 0.252 0.000
M24.0 Loose body in joint
0.747 0.252 0.000
M35 Other systemic involvement of connective tissue
0.746 0.254 0.000
M49 Spondylopathies in diseases classified elsewhere
0.745 0.255 0.000
V10-V19 Pedal cyclist injured in transport accident
0.745 0.255 0.000
S70-S79 Injuries to the hip and thigh
0.744 0.256 0.000
E14 Unspecified diabetes mellitus
0.743 0.257 0.000
I72.3 Aneurysm of iliac artery
0.742 0.258 0.000
I22.8 Subsequent myocardial infarction of other sites
0.741 0.259 0.000
Y52 Agents primarily affecting the cardiovascular system
0.741 0.259 0.000
T58 Toxic effect of carbon monoxide
0.741 0.259 0.000
I51.7 Cardiomegaly
0.740 0.260 0.000
T51.0 Ethanol
0.740 0.260 0.000
I37 Pulmonary valve disorders
0.736 0.264 0.000
M80-M85 Disorders of bone density and structure
0.736 0.264 0.000
I73.9 Peripheral vascular disease, unspecified
0.734 0.266 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.733 0.267 0.000
M48 Other spondylopathies
0.731 0.269 0.000
I35.9 Aortic valve disorder, unspecified
0.731 0.269 0.000
S31 Open wound of abdomen, lower back and pelvis
0.730 0.270 0.000
I72.8 Aneurysm of other specified arteries
0.730 0.270 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.729 0.271 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.729 0.271 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.729 0.271 0.000
M25.77 Osteophyte (Ankle and foot)
0.729 0.271 0.000
M66 Spontaneous rupture of synovium and tendon
0.727 0.273 0.000
M24.5 Contracture of joint
0.727 0.273 0.000
I77 Other disorders of arteries and arterioles
0.727 0.273 0.000
S42.2 Fracture of upper end of humerus
0.726 0.274 0.000
S40.9 Superficial injury of shoulder and upper arm, unspecified
0.726 0.274 0.000
M24.86 Other specific joint derangements, not elsewhere classified (Lower leg)
0.726 0.274 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.724 0.276 0.000
I08 Multiple valve diseases
0.724 0.276 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.723 0.277 0.000
W00-W19 Falls
0.723 0.277 0.000
M91-M94 Chondropathies
0.722 0.278 0.000
G91 Hydrocephalus
0.721 0.278 0.000
Y60.0 During surgical operation
0.720 0.280 0.000
V20-V29 Motorcycle rider injured in transport accident
0.719 0.281 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.719 0.281 0.000
F60-F69 Disorders of adult personality and behaviour
0.718 0.281 0.000
M25.46 Effusion of joint (Lower leg)
0.718 0.282 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
M00-M03 Infectious arthropathies
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
I23 Certain current complications following acute myocardial infarction
0.717 0.283 0.000
E66.2 Extreme obesity with alveolar hypoventilation
0.717 0.283 0.000
E66.1 Drug-induced obesity
0.717 0.283 0.000
E66.0 Obesity due to excess calories
0.717 0.283 0.000
I25.6 Silent myocardial ischaemia
0.717 0.283 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.717 0.283 0.000
E67 Other hyperalimentation
0.716 0.283 0.000
E68 Sequelae of hyperalimentation
0.716 0.283 0.000
E65 Localised adiposity
0.716 0.283 0.000
I52 Other heart disorders in diseases classified elsewhere
0.716 0.284 0.000
I48 Atrial fibrillation and flutter
0.716 0.284 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.716 0.284 0.000
I41 Myocarditis in diseases classified elsewhere
0.716 0.284 0.000
I40 Acute myocarditis
0.716 0.284 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.716 0.284 0.000
I32 Pericarditis in diseases classified elsewhere
0.716 0.284 0.000
E40-E46 Malnutrition
0.716 0.284 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.716 0.284 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.715 0.285 0.000
Y35-Y36 Legal intervention and operations of war
0.715 0.285 0.000
Y10-Y34 Event of undetermined intent
0.715 0.285 0.000
Y00-Y09 Assault
0.715 0.285 0.000
X85-X99 Assault
0.715 0.285 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.715 0.285 0.000
X50-X57 Overexertion, travel and privation
0.715 0.285 0.000
X30-X39 Exposure to forces of nature
0.715 0.285 0.000
X20-X29 Contact with venomous animals and plants
0.715 0.285 0.000
X10-X19 Contact with heat and hot substances
0.715 0.285 0.000
X00-X09 Exposure to smoke, fire and flames
0.715 0.285 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.715 0.285 0.000
W75-W84 Other accidental threats to breathing
0.715 0.285 0.000
W65-W74 Accidental drowning and submersion
0.715 0.285 0.000
W50-W64 Exposure to animate mechanical forces
0.715 0.285 0.000
V98-V99 Other and unspecified transport accidents
0.715 0.285 0.000
V95-V97 Air and space transport accidents
0.715 0.285 0.000
V90-V94 Water transport accidents
0.715 0.285 0.000
V70-V79 Bus occupant injured in transport accident
0.715 0.285 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.715 0.285 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.715 0.285 0.000
V40-V49 Car occupant injured in transport accident
0.715 0.285 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.715 0.285 0.000
V01-V09 Pedestrian injured in transport accident
0.715 0.285 0.000
I33 Acute and subacute endocarditis
0.715 0.285 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.714 0.286 0.000
M33 Dermatopolymyositis
0.714 0.286 0.000
M32 Systemic lupus erythematosus
0.714 0.286 0.000
M30 Polyarteritis nodosa and related conditions
0.714 0.286 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.714 0.286 0.000
G70-G73 Diseases of myoneural junction and muscle
0.713 0.286 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.713 0.287 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.713 0.287 0.000
F70-F79 Mental retardation
0.713 0.287 0.000
T33-T35 Frostbite
0.712 0.288 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.712 0.288 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.712 0.288 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.712 0.288 0.000
T00-T07 Injuries involving multiple body regions
0.712 0.288 0.000
M65 Synovitis and tenosynovitis
0.712 0.288 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.711 0.289 0.000
M45 Ankylosing spondylitis
0.711 0.289 0.000
S90-S99 Injuries to the ankle and foot
0.711 0.289 0.000
F99-F99 Unspecified mental disorder
0.708 0.291 0.000
F41.9 Anxiety disorder, unspecified
0.708 0.292 0.000
F31 Bipolar affective disorder
0.707 0.293 0.000
G96 Other disorders of central nervous system
0.707 0.293 0.000
M75.8 Other shoulder lesions
0.706 0.294 0.000
F01 Vascular dementia
0.706 0.294 0.000
M25.61 Stiffness of joint, not elsewhere classified (Shoulder region)
0.705 0.295 0.000
R45 Symptoms and signs involving emotional state
0.704 0.296 0.000
M21 Other acquired deformities of limbs
0.703 0.297 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.702 0.297 0.000
I21.9 Acute myocardial infarction, unspecified
0.702 0.298 0.000
M25.76 Osteophyte (Lower leg)
0.702 0.298 0.000
Chapter XXII Codes for special purposes
0.700 0.300 0.000
R47-R49 Symptoms and signs involving speech and voice
0.700 0.300 0.000
M79.1 Myalgia
0.699 0.301 0.000
F48 Other neurotic disorders
0.697 0.302 0.000
F44 Dissociative [conversion] disorders
0.697 0.302 0.000
F42 Obsessive-compulsive disorder
0.697 0.302 0.000
I51.0 Cardiac septal defect, acquired
0.697 0.303 0.000
M25.9 Joint disorder, unspecified
0.697 0.303 0.000
M25.3 Other instability of joint
0.697 0.303 0.000
M25.2 Flail joint
0.697 0.303 0.000
M25.1 Fistula of joint
0.697 0.303 0.000
M25.0 Haemarthrosis
0.697 0.303 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.697 0.303 0.000
Y85 Sequelae of transport accidents
0.696 0.304 0.000
M47 Spondylosis
0.696 0.304 0.000
M24.9 Joint derangement, unspecified
0.696 0.304 0.000
M24.7 Protrusio acetabuli
0.696 0.304 0.000
M24.6 Ankylosis of joint
0.696 0.304 0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified
0.696 0.304 0.000
M24.2 Disorder of ligament
0.696 0.304 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.695 0.305 0.000
G58 Other mononeuropathies
0.693 0.306 0.000
F41.8 Other specified anxiety disorders
0.693 0.307 0.000
F41.3 Other mixed anxiety disorders
0.693 0.307 0.000
M24.85 Other specific joint derangements, not elsewhere classified (Pelvic region and thigh)
0.691 0.309 0.000
M24.13 Other articular cartilage disorders (Forearm)
0.690 0.310 0.000
S27 Injury of other and unspecified intrathoracic organs
0.690 0.310 0.000
M25.72 Osteophyte (Upper arm)
0.689 0.311 0.000
M23.2 Derangement of meniscus due to old tear or injury
0.689 0.311 0.000
M25.74 Osteophyte (Hand)
0.689 0.311 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.688 0.312 0.000
M34.9 Systemic sclerosis, unspecified
0.688 0.312 0.000
F06 Other mental disorders due to brain damage and dysfunction and to physical disease
0.688 0.312 0.000
M22.2 Patellofemoral disorders
0.687 0.313 0.000
M46.9 Inflammatory spondylopathy, unspecified
0.687 0.313 0.000
I22.1 Subsequent myocardial infarction of inferior wall
0.686 0.314 0.000
I51.4 Myocarditis, unspecified
0.685 0.315 0.000
M79.6 Pain in limb
0.685 0.315 0.000
I42 Cardiomyopathy
0.684 0.316 0.000
I50.0 Congestive heart failure
0.684 0.316 0.000
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle
0.682 0.318 0.000
G53 Cranial nerve disorders in diseases classified elsewhere
0.681 0.319 0.000
G52 Disorders of other cranial nerves
0.681 0.319 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.681 0.319 0.000
M18.1 Other primary arthrosis of first carpometacarpal joint
0.681 0.319 0.000
I51.8 Other ill-defined heart diseases
0.681 0.319 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.679 0.320 0.000
I70.2 Atherosclerosis of arteries of the extremities
0.679 0.321 0.000
E10.4 With neurological complications
0.679 0.321 0.000
I35.8 Other aortic valve disorders
0.678 0.322 0.000
F80 Specific developmental disorders of speech and language
0.676 0.323 0.000
S48 Traumatic amputation of shoulder and upper arm
0.676 0.324 0.000
S45 Injury of blood vessels at shoulder and upper arm level
0.676 0.324 0.000
S44 Injury of nerves at shoulder and upper arm level
0.676 0.324 0.000
S41 Open wound of shoulder and upper arm
0.676 0.324 0.000
S47 Crushing injury of shoulder and upper arm
0.676 0.324 0.000
F52 Sexual dysfunction, not caused by organic disorder or disease
0.675 0.325 0.000
F33 Recurrent depressive disorder
0.675 0.325 0.000
M42 Spinal osteochondrosis
0.674 0.326 0.000
M40 Kyphosis and lordosis
0.674 0.326 0.000
I24 Other acute ischaemic heart diseases
0.674 0.326 0.000
E11 Non-insulin-dependent diabetes mellitus
0.674 0.326 0.000
R40 Somnolence, stupor and coma
0.674 0.326 0.000
Y59 Other and unspecified vaccines and biological substances
0.673 0.326 0.000
Y58 Bacterial vaccines
0.673 0.326 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.673 0.326 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.673 0.326 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.673 0.326 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.673 0.326 0.000
Y48 Anaesthetics and therapeutic gases
0.673 0.326 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.673 0.326 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.673 0.326 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.672 0.327 0.000
G40-G47 Episodic and paroxysmal disorders
0.671 0.329 0.000
S30.0 Contusion of lower back and pelvis
0.671 0.329 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.671 0.329 0.000
G56.9 Mononeuropathy of upper limb, unspecified
0.670 0.329 0.000
G56.8 Other mononeuropathies of upper limb
0.670 0.329 0.000
G56.4 Causalgia
0.670 0.329 0.000
G56.3 Lesion of radial nerve
0.670 0.329 0.000
G56.1 Other lesions of median nerve
0.670 0.329 0.000
G94 Other disorders of brain in diseases classified elsewhere
0.670 0.330 0.000
G90 Disorders of autonomic nervous system
0.670 0.330 0.000
G98 Other disorders of nervous system, not elsewhere classified
0.670 0.330 0.000
G92 Toxic encephalopathy
0.670 0.330 0.000
I73.8 Other specified peripheral vascular diseases
0.669 0.331 0.000
I73.1 Thromboangiitis obliterans [Buerger]
0.669 0.331 0.000
I34.9 Nonrheumatic mitral valve disorder, unspecified
0.669 0.331 0.000
I34.8 Other nonrheumatic mitral valve disorders
0.669 0.331 0.000
I34.2 Nonrheumatic mitral (valve) stenosis
0.669 0.331 0.000
I30.9 Acute pericarditis, unspecified
0.669 0.331 0.000
I34.1 Mitral (valve) prolapse
0.667 0.333 0.000
M15 Polyarthrosis
0.667 0.333 0.000
I05 Rheumatic mitral valve diseases
0.666 0.334 0.000
I07 Rheumatic tricuspid valve diseases
0.666 0.334 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.666 0.334 0.000
S22.0 Fracture of thoracic vertebra
0.665 0.335 0.000
G25 Other extrapyramidal and movement disorders
0.665 0.335 0.000
S21.2 Open wound of back wall of thorax
0.664 0.336 0.000
R46 Symptoms and signs involving appearance and behaviour
0.664 0.336 0.000
I22.9 Subsequent myocardial infarction of unspecified site
0.663 0.337 0.000
G93.9 Disorder of brain, unspecified
0.663 0.337 0.000
Y89 Sequelae of other external causes
0.662 0.337 0.000
Y87 Sequelae of intentional self-harm, assault and events of undetermined intent
0.662 0.337 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.662 0.338 0.000
M25.85 Other specified joint disorders (Pelvic region and thigh)
0.662 0.338 0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.661 0.339 0.000
T51.9 Alcohol, unspecified
0.661 0.339 0.000
G93.3 Postviral fatigue syndrome
0.661 0.339 0.000
S42.9 Fracture of shoulder girdle, part unspecified
0.660 0.339 0.000
M79.5 Residual foreign body in soft tissue
0.660 0.340 0.000
M77.1 Lateral epicondylitis
0.658 0.341 0.000
S42.0 Fracture of clavicle
0.658 0.342 0.000
M86-M90 Other osteopathies
0.657 0.343 0.000
F41.1 Generalised anxiety disorder
0.656 0.344 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.655 0.345 0.000
T65 Toxic effect of other and unspecified substances
0.654 0.345 0.000
T63 Toxic effect of contact with venomous animals
0.654 0.345 0.000
T62 Toxic effect of other noxious substances eaten as food
0.654 0.345 0.000
T61 Toxic effect of noxious substances eaten as seafood
0.654 0.345 0.000
T60 Toxic effect of pesticides
0.654 0.345 0.000
T59 Toxic effect of other gases, fumes and vapours
0.654 0.345 0.000
T57 Toxic effect of other inorganic substances
0.654 0.345 0.000
T56 Toxic effect of metals
0.654 0.345 0.000
T54 Toxic effect of corrosive substances
0.654 0.345 0.000
T53 Toxic effect of halogen derivatives of aliphatic and aromatic hydrocarbone
0.654 0.345 0.000
T52 Toxic effect of organic solvents
0.654 0.345 0.000
T64 Toxic effect of aflatoxin and other mycotoxin food contaminants
0.654 0.345 0.000
T55 Toxic effect of soaps and detergents
0.654 0.345 0.000
S38 Crushing injury and traumatic amputation of part of abdomen, lower back and pelvis
0.654 0.346 0.000
S37 Injury of urinary and pelvic organs
0.654 0.346 0.000
S36 Injury of intra-abdominal organs
0.654 0.346 0.000
S35 Injury of blood vessels at abdomen, lower back and pelvis level
0.654 0.346 0.000
S34 Injury of nerves and lumbar spinal cord at abdomen, lower back and pelvis level
0.654 0.346 0.000
S33 Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis
0.654 0.346 0.000
M19.93 Arthrosis, unspecified (Forearm)
0.654 0.346 0.000
M76.6 Achilles tendinitis
0.653 0.347 0.000
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts
0.652 0.348 0.000
M75.3 Calcific tendinitis of shoulder
0.651 0.348 0.000
I72.9 Aneurysm of unspecified site
0.651 0.349 0.000
I72.6 Aneurysm and dissection of vertebral artery
0.651 0.349 0.000
I72.5 Aneurysm and dissection of other precerebral arteries
0.651 0.349 0.000
I72.2 Aneurysm of renal artery
0.651 0.349 0.000
I72.1 Aneurysm of artery of upper extremity
0.651 0.349 0.000
I72.0 Aneurysm of carotid artery
0.651 0.349 0.000
G93.2 Benign intracranial hypertension
0.651 0.349 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.650 0.350 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.649 0.351 0.000
M79.2 Neuralgia and neuritis, unspecified
0.649 0.351 0.000
M23.3 Other meniscus derangements
0.649 0.351 0.000
M24.19 Other articular cartilage disorders (Site unspecified)
0.649 0.351 0.000
M24.18 Other articular cartilage disorders (Other)
0.649 0.351 0.000
M24.17 Other articular cartilage disorders (Ankle and foot)
0.649 0.351 0.000
M24.15 Other articular cartilage disorders (Pelvic region and thigh)
0.649 0.351 0.000
M24.14 Other articular cartilage disorders (Hand)
0.649 0.351 0.000
M24.12 Other articular cartilage disorders (Upper arm)
0.649 0.351 0.000
M24.10 Other articular cartilage disorders (Multiple sites)
0.649 0.351 0.000
I21.X Presumed acute myicardial infaction (unconfirmed)
0.648 0.351 0.000
I21.3 Acute transmural myocardial infarction of unspecified site
0.648 0.351 0.000
M19.92 Arthrosis, unspecified (Upper arm)
0.648 0.352 0.000
Y40.0 Penicillins
0.647 0.353 0.000
G80 Infantile cerebral palsy
0.646 0.354 0.000
S39 Other and unspecified injuries of abdomen, lower back and pelvis
0.646 0.354 0.000
G59.0 Diabetic mononeuropathy
0.645 0.355 0.000
G54 Nerve root and plexus disorders
0.644 0.355 0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis
0.644 0.355 0.000
S29 Other and unspecified injuries of thorax
0.644 0.356 0.000
S28 Crushing injury of thorax and traumatic amputation of part of thorax
0.644 0.356 0.000
S26 Injury of heart
0.644 0.356 0.000
S25 Injury of blood vessels of thorax
0.644 0.356 0.000
S24 Injury of nerves and spinal cord at thorax level
0.644 0.356 0.000
S23 Dislocation, sprain and strain of joints and ligaments of thorax
0.644 0.356 0.000
L40-L45 Papulosquamous disorders
0.643 0.357 0.000
E20-E35 Disorders of other endocrine glands
0.643 0.357 0.000
T36 Poisoning by systemic antibiotics
0.643 0.357 0.000
E12 Malnutrition-related diabetes mellitus
0.643 0.357 0.000
M43.0 Spondylolysis
0.643 0.357 0.000
I71 Aortic aneurysm and dissection
0.642 0.358 0.000
S42.20 Fracture of upper end of humerus (closed)
0.642 0.358 0.000
G97.8 Other postprocedural disorders of nervous system
0.642 0.358 0.000
T40.4 Other synthetic narcotics
0.641 0.358 0.000
F84 Pervasive developmental disorders
0.641 0.359 0.000
F89 Unspecified disorder of psychological development
0.641 0.359 0.000
F88 Other disorders of psychological development
0.641 0.359 0.000
F83 Mixed specific developmental disorders
0.641 0.359 0.000
F82 Specific developmental disorder of motor function
0.641 0.359 0.000
E14.3 With ophthalmic complications
0.641 0.359 0.000
S80-S89 Injuries to the knee and lower leg
0.639 0.361 0.000
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)
0.639 0.361 0.000
F43 Reaction to severe stress, and adjustment disorders
0.639 0.361 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.639 0.361 0.000
G62 Other polyneuropathies
0.638 0.362 0.000
M19.98 Arthrosis, unspecified (Other)
0.637 0.363 0.000
M72 Fibroblastic disorders
0.636 0.364 0.000
S40.0 Contusion of shoulder and upper arm
0.635 0.365 0.000
I27 Other pulmonary heart diseases
0.634 0.366 0.000
I31.9 Disease of pericardium, unspecified
0.633 0.367 0.000
R93.7 Abnormal findings on diagnostic imaging of other parts of musculoskeletal system
0.633 0.367 0.000
I22.0 Subsequent myocardial infarction of anterior wall
0.633 0.367 0.000
S49 Other and unspecified injuries of shoulder and upper arm
0.632 0.368 0.000
F07 Personality and behavioural disorders due to brain disease, damage and dysfunction
0.632 0.368 0.000
F02 Dementia in other diseases classified elsewhere
0.632 0.368 0.000
F09 Unspecified organic or symptomatic mental disorder
0.632 0.368 0.000
F04 Organic amnesic syndrome, not induced by alcohol and other psychoactive substances
0.632 0.368 0.000
R41 Other symptoms and signs involving cognitive functions and awareness
0.632 0.368 0.000
Y43.0 Antiallergic and antiemetic drugs
0.632 0.368 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.631 0.369 0.000
M46.4 Discitis, unspecified
0.630 0.370 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.629 0.370 0.000
S42.1 Fracture of scapula
0.629 0.371 0.000
M43.1 Spondylolisthesis
0.628 0.372 0.000
S32 Fracture of lumbar spine and pelvis
0.627 0.372 0.000
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts
0.627 0.373 0.000
G50 Disorders of trigeminal nerve
0.627 0.373 0.000
G24 Dystonia
0.627 0.373 0.000
Y91 Evidence of alcohol involvement determined by level of intoxication
0.627 0.373 0.000
Y90 Evidence of alcohol involvement determined by blood alcohol level
0.627 0.373 0.000
Y98 Lifestyle-related condition
0.627 0.373 0.000
Y97 Environmental-pollution-related condition
0.627 0.373 0.000
Y96 Work-related condition
0.627 0.373 0.000
I78 Diseases of capillaries
0.626 0.373 0.000
I31.8 Other specified diseases of pericardium
0.626 0.374 0.000
I31.2 Haemopericardium, not elsewhere classified
0.626 0.374 0.000
I31.1 Chronic constrictive pericarditis
0.626 0.374 0.000
I31.0 Chronic adhesive pericarditis
0.626 0.374 0.000
Y65 Other misadventures during surgical and medical care
0.626 0.374 0.000
Y64 Contaminated medical or biological substances
0.626 0.374 0.000
Y63 Failure in dosage during surgical and medical care
0.626 0.374 0.000
Y62 Failure of sterile precautions during surgical and medical care
0.626 0.374 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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