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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs76677480
log Bayes Factor = 13.266
Chromosome 4   position 7,095,114  (GRCh37) Explore rs76677480 on Ensembl!
Variant rs76677480 is part of Cluster X0039

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter VII Diseases of the eye and adnexa
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.999 0.001 0.000
H30-H36 Disorders of choroid and retina
0.999 0.001 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.999 0.001 0.000
E10-E14 Diabetes mellitus
0.998 0.002 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.997 0.003 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.994 0.006 0.000
I20-I25 Ischaemic heart diseases
0.993 0.007 0.000
H33 Retinal detachments and breaks
0.993 0.007 0.000
E11 Non-insulin-dependent diabetes mellitus
0.992 0.008 0.000
E11.9 Without complications
0.983 0.017 0.000
R30-R39 Symptoms and signs involving the urinary system
0.982 0.018 0.000
H33.0 Retinal detachment with retinal break
0.976 0.024 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.975 0.025 0.000
H35 Other retinal disorders
0.974 0.026 0.000
I21 Acute myocardial infarction
0.970 0.030 0.000
M20-M25 Other joint disorders
0.966 0.034 0.000
I25 Chronic ischaemic heart disease
0.960 0.040 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.959 0.041 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.959 0.041 0.000
Chapter II Neoplasms
0.958 0.042 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.956 0.044 0.000
I21.1 Acute transmural myocardial infarction of inferior wall
0.955 0.045 0.000
I74 Arterial embolism and thrombosis
0.952 0.048 0.000
I73 Other peripheral vascular diseases
0.952 0.048 0.000
H35.3 Degeneration of macula and posterior pole
0.950 0.050 0.000
I60-I69 Cerebrovascular diseases
0.947 0.053 0.000
R32 Unspecified urinary incontinence
0.932 0.068 0.000
Chapter VI Diseases of the nervous system
0.932 0.068 0.000
I73.9 Peripheral vascular disease, unspecified
0.931 0.069 0.000
I71 Aortic aneurysm and dissection
0.928 0.072 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.927 0.073 0.000
E20-E35 Disorders of other endocrine glands
0.927 0.073 0.000
M23 Internal derangement of knee
0.925 0.075 0.000
Chapter XX External causes of morbidity and mortality
0.915 0.085 0.000
M24 Other specific joint derangements
0.913 0.087 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.912 0.088 0.000
C50-C50 Malignant neoplasm of breast
0.911 0.089 0.000
H33.2 Serous retinal detachment
0.911 0.089 0.000
R33 Retention of urine
0.909 0.091 0.000
I05-I09 Chronic rheumatic heart diseases
0.908 0.092 0.000
I25.2 Old myocardial infarction
0.908 0.092 0.000
M23.2 Derangement of meniscus due to old tear or injury
0.907 0.093 0.000
R39 Other symptoms and signs involving the urinary system
0.906 0.094 0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.906 0.094 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.905 0.095 0.000
E14 Unspecified diabetes mellitus
0.905 0.095 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.902 0.098 0.000
H25-H28 Disorders of lens
0.895 0.105 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.888 0.112 0.000
E11.4 With neurological complications
0.888 0.112 0.000
R21 Rash and other nonspecific skin eruption
0.885 0.115 0.000
S40-S49 Injuries to the shoulder and upper arm
0.881 0.119 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.880 0.120 0.000
S70-S79 Injuries to the hip and thigh
0.880 0.120 0.000
M22 Disorders of patella
0.878 0.122 0.000
C50 Malignant neoplasm of breast
0.878 0.122 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.877 0.123 0.000
S50-S59 Injuries to the elbow and forearm
0.869 0.131 0.000
R42 Dizziness and giddiness
0.867 0.133 0.000
M23.23 Derangement of meniscus due to old tear or injury (Medial collateral ligament or Other and unspecified medial meniscus)
0.866 0.134 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.864 0.136 0.000
D60-D64 Aplastic and other anaemias
0.863 0.137 0.000
E10 Insulin-dependent diabetes mellitus
0.861 0.139 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.858 0.142 0.000
I30-I52 Other forms of heart disease
0.858 0.142 0.000
H26 Other cataract
0.858 0.142 0.000
M23.22 Derangement of meniscus due to old tear or injury (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.851 0.149 0.000
I25.9 Chronic ischaemic heart disease, unspecified
0.848 0.152 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.845 0.155 0.000
S20-S29 Injuries to the thorax
0.842 0.158 0.000
R41 Other symptoms and signs involving cognitive functions and awareness
0.840 0.160 0.000
C79 Secondary malignant neoplasm of other sites
0.837 0.163 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.836 0.164 0.000
Chapter XXII Codes for special purposes
0.835 0.165 0.000
C50.9 Breast, unspecified
0.835 0.165 0.000
I77 Other disorders of arteries and arterioles
0.832 0.168 0.000
R39.8 Other and unspecified symptoms and signs involving the urinary system
0.829 0.171 0.000
I69 Sequelae of cerebrovascular disease
0.828 0.172 0.000
I51 Complications and ill-defined descriptions of heart disease
0.826 0.174 0.000
G81 Hemiplegia
0.823 0.177 0.000
I08 Multiple valve diseases
0.819 0.181 0.000
R26 Abnormalities of gait and mobility
0.812 0.188 0.000
C50.8 Overlapping lesion of breast
0.812 0.188 0.000
H55-H59 Other disorders of eye and adnexa
0.811 0.189 0.000
M24.1 Other articular cartilage disorders
0.809 0.191 0.000
D46 Myelodysplastic syndromes
0.807 0.193 0.000
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.805 0.195 0.000
M31 Other necrotising vasculopathies
0.800 0.200 0.000
I95 Hypotension
0.800 0.200 0.000
E50-E64 Other nutritional deficiencies
0.800 0.200 0.000
I71.0 Dissection of aorta [any part]
0.798 0.202 0.000
I35 Nonrheumatic aortic valve disorders
0.797 0.203 0.000
H26.9 Cataract, unspecified
0.797 0.203 0.000
R25 Abnormal involuntary movements
0.796 0.204 0.000
S72 Fracture of femur
0.796 0.204 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.794 0.206 0.000
T86 Failure and rejection of transplanted organs and tissues
0.791 0.209 0.000
M40-M43 Deforming dorsopathies
0.790 0.210 0.000
E14.9 Without complications
0.790 0.210 0.000
D45 Polycythaemia vera
0.789 0.211 0.000
I24 Other acute ischaemic heart diseases
0.789 0.211 0.000
I64 Stroke, not specified as haemorrhage or infarction
0.787 0.213 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.786 0.214 0.000
G81.9 Hemiplegia, unspecified
0.785 0.215 0.000
M80-M85 Disorders of bone density and structure
0.783 0.217 0.000
C60-C63 Malignant neoplasms of male genital organs
0.782 0.218 0.000
C79.3 Secondary malignant neoplasm of brain and cerebral meninges
0.779 0.221 0.000
G90-G99 Other disorders of the nervous system
0.778 0.222 0.000
H43-H45 Disorders of vitreous body and globe
0.778 0.222 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.777 0.223 0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.775 0.225 0.000
E11.1 With ketoacidosis
0.775 0.225 0.000
M91-M94 Chondropathies
0.774 0.226 0.000
M21 Other acquired deformities of limbs
0.772 0.228 0.000
S10-S19 Injuries to the neck
0.772 0.228 0.000
I10-I15 Hypertensive diseases
0.771 0.228 0.000
W00-W19 Falls
0.772 0.228 0.000
H36 Retinal disorders in diseases classified elsewhere
0.771 0.229 0.000
D64 Other anaemias
0.770 0.230 0.000
R40 Somnolence, stupor and coma
0.770 0.230 0.000
I21.2 Acute transmural myocardial infarction of other sites
0.769 0.231 0.000
I61 Intracerebral haemorrhage
0.768 0.232 0.000
I70 Atherosclerosis
0.767 0.233 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.767 0.233 0.000
I25.8 Other forms of chronic ischaemic heart disease
0.766 0.234 0.000
M22.4 Chondromalacia patellae
0.765 0.235 0.000
D70 Agranulocytosis
0.764 0.236 0.000
G30-G32 Other degenerative diseases of the nervous system
0.764 0.236 0.000
R27 Other lack of coordination
0.764 0.236 0.000
M24.0 Loose body in joint
0.763 0.237 0.000
D75 Other diseases of blood and blood-forming organs
0.760 0.240 0.000
M86-M90 Other osteopathies
0.759 0.241 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.759 0.241 0.000
I21.4 Acute subendocardial myocardial infarction
0.757 0.242 0.000
D80-D89 Certain disorders involving the immune mechanism
0.756 0.243 0.000
H33.5 Other retinal detachments
0.756 0.244 0.000
E14.3 With ophthalmic complications
0.756 0.244 0.000
E70-E90 Metabolic disorders
0.754 0.245 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.753 0.247 0.000
M05-M14 Inflammatory polyarthropathies
0.752 0.248 0.000
E40-E46 Malnutrition
0.752 0.248 0.000
I74.5 Embolism and thrombosis of iliac artery
0.752 0.248 0.000
E22 Hyperfunction of pituitary gland
0.752 0.248 0.000
M24.2 Disorder of ligament
0.751 0.249 0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.751 0.249 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.751 0.249 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.750 0.250 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.750 0.250 0.000
V10-V19 Pedal cyclist injured in transport accident
0.749 0.251 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.749 0.251 0.000
I78 Diseases of capillaries
0.748 0.252 0.000
R41.0 Disorientation, unspecified
0.748 0.252 0.000
H35.4 Peripheral retinal degeneration
0.747 0.253 0.000
T87 Complications peculiar to reattachment and amputation
0.746 0.253 0.000
S52 Fracture of forearm
0.746 0.254 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.746 0.254 0.000
E24 Cushing's syndrome
0.746 0.254 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.746 0.254 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.745 0.255 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.744 0.256 0.000
I60 Subarachnoid haemorrhage
0.743 0.257 0.000
C80 Malignant neoplasm without specification of site
0.741 0.259 0.000
I51.8 Other ill-defined heart diseases
0.739 0.261 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.738 0.262 0.000
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts
0.738 0.262 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.737 0.263 0.000
M24.16 Other articular cartilage disorders (Lower leg)
0.734 0.266 0.000
I51.7 Cardiomegaly
0.733 0.266 0.000
E27 Other disorders of adrenal gland
0.733 0.267 0.000
S42 Fracture of shoulder and upper arm
0.732 0.268 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.732 0.268 0.000
I95.9 Hypotension, unspecified
0.732 0.268 0.000
R30 Pain associated with micturition
0.731 0.269 0.000
T66-T78 Other and unspecified effects of external causes
0.730 0.269 0.000
H35.8 Other specified retinal disorders
0.730 0.270 0.000
H34 Retinal vascular occlusions
0.729 0.271 0.000
R39.1 Other difficulties with micturition
0.728 0.272 0.000
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites
0.726 0.274 0.000
T83.8 Other complications of genito-urinary prosthetic devices, implants and grafts
0.726 0.274 0.000
Chapter V Mental and behavioural disorders
0.725 0.275 0.000
D72 Other disorders of white blood cells
0.724 0.276 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.723 0.277 0.000
I72 Other aneurysm
0.723 0.277 0.000
M34 Systemic sclerosis
0.723 0.277 0.000
S27 Injury of other and unspecified intrathoracic organs
0.723 0.277 0.000
T79-T79 Certain early complications of trauma
0.721 0.278 0.000
H10-H13 Disorders of conjunctiva
0.721 0.278 0.000
D46.9 Myelodysplastic syndrome, unspecified
0.721 0.279 0.000
D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs
0.721 0.279 0.000
E23 Hypofunction and other disorders of pituitary gland
0.721 0.279 0.000
S72.0 Fracture of neck of femur
0.721 0.279 0.000
I49 Other cardiac arrhythmias
0.718 0.282 0.000
I67 Other cerebrovascular diseases
0.718 0.282 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.717 0.283 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.716 0.284 0.000
H31 Other disorders of choroid
0.716 0.284 0.000
H30 Chorioretinal inflammation
0.716 0.284 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.716 0.284 0.000
E13 Other specified diabetes mellitus
0.715 0.284 0.000
E12 Malnutrition-related diabetes mellitus
0.715 0.284 0.000
T33-T35 Frostbite
0.714 0.285 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.714 0.285 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.714 0.285 0.000
T00-T07 Injuries involving multiple body regions
0.714 0.285 0.000
T82.0 Mechanical complication of heart valve prosthesis
0.713 0.287 0.000
I77.1 Stricture of artery
0.713 0.287 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.712 0.288 0.000
I23 Certain current complications following acute myocardial infarction
0.712 0.288 0.000
H33.4 Traction detachment of retina
0.712 0.288 0.000
H33.1 Retinoschisis and retinal cysts
0.712 0.288 0.000
E11.8 With unspecified complications
0.711 0.289 0.000
E11.7 With multiple complications
0.711 0.289 0.000
E11.6 With other specified complications
0.711 0.289 0.000
E11.0 With coma
0.711 0.289 0.000
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.711 0.289 0.000
M22.8 Other disorders of patella
0.710 0.290 0.000
E10.9 Without complications
0.710 0.290 0.000
R25.1 Tremor, unspecified
0.708 0.292 0.000
M45-M49 Spondylopathies
0.707 0.293 0.000
R76 Other abnormal immunological findings in serum
0.706 0.294 0.000
H26.8 Other specified cataract
0.706 0.294 0.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes
0.705 0.295 0.000
T83.4 Mechanical complication of other prosthetic devices, implants and grafts in genital tract
0.705 0.295 0.000
R36 Urethral discharge
0.704 0.296 0.000
R34 Anuria and oliguria
0.704 0.296 0.000
D64.9 Anaemia, unspecified
0.704 0.296 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.703 0.296 0.000
I08.0 Disorders of both mitral and aortic valves
0.702 0.298 0.000
R26.8 Other and unspecified abnormalities of gait and mobility
0.702 0.298 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.701 0.299 0.000
E11.3 With ophthalmic complications
0.700 0.300 0.000
M60-M63 Disorders of muscles
0.699 0.301 0.000
M00-M03 Infectious arthropathies
0.699 0.301 0.000
H35.9 Retinal disorder, unspecified
0.698 0.301 0.000
H35.7 Separation of retinal layers
0.698 0.301 0.000
H35.6 Retinal haemorrhage
0.698 0.301 0.000
H35.5 Hereditary retinal dystrophy
0.698 0.301 0.000
H35.2 Other proliferative retinopathy
0.698 0.301 0.000
H35.1 Retinopathy of prematurity
0.698 0.301 0.000
R45 Symptoms and signs involving emotional state
0.697 0.303 0.000
S90-S99 Injuries to the ankle and foot
0.697 0.303 0.000
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle
0.696 0.304 0.000
I63 Cerebral infarction
0.696 0.304 0.000
I21.X Presumed acute myicardial infaction (unconfirmed)
0.695 0.305 0.000
I21.3 Acute transmural myocardial infarction of unspecified site
0.695 0.305 0.000
S80-S89 Injuries to the knee and lower leg
0.695 0.305 0.000
H04 Disorders of lachrymal system
0.694 0.306 0.000
S49 Other and unspecified injuries of shoulder and upper arm
0.694 0.306 0.000
I07 Rheumatic tricuspid valve diseases
0.694 0.306 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.693 0.307 0.000
M33 Dermatopolymyositis
0.693 0.307 0.000
M32 Systemic lupus erythematosus
0.693 0.307 0.000
M30 Polyarteritis nodosa and related conditions
0.693 0.307 0.000
M23.4 Loose body in knee
0.692 0.308 0.000
H35.0 Background retinopathy and retinal vascular changes
0.691 0.309 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.691 0.309 0.000
X60-X84 Intentional self-harm
0.690 0.310 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.690 0.310 0.000
I22 Subsequent myocardial infarction
0.689 0.311 0.000
I25.6 Silent myocardial ischaemia
0.688 0.312 0.000
I25.4 Coronary artery aneurysm
0.688 0.312 0.000
I25.3 Aneurysm of heart
0.688 0.312 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.688 0.312 0.000
M23.21 Derangement of meniscus due to old tear or injury (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.688 0.312 0.000
G70-G73 Diseases of myoneural junction and muscle
0.688 0.312 0.000
D55-D59 Haemolytic anaemias
0.687 0.312 0.000
C50.5 Lower-outer quadrant of breast
0.687 0.313 0.000
H26.4 After-cataract
0.687 0.313 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.687 0.313 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.687 0.313 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.687 0.313 0.000
I21.0 Acute transmural myocardial infarction of anterior wall
0.686 0.314 0.000
C50.3 Lower-inner quadrant of breast
0.686 0.314 0.000
R46 Symptoms and signs involving appearance and behaviour
0.685 0.315 0.000
R43 Disturbances of smell and taste
0.685 0.315 0.000
I25.5 Ischaemic cardiomyopathy
0.685 0.315 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.685 0.315 0.000
E11.2 With renal complications
0.685 0.315 0.000
O00-O08 Pregnancy with abortive outcome
0.684 0.316 0.000
I05 Rheumatic mitral valve diseases
0.684 0.316 0.000
G62 Other polyneuropathies
0.683 0.317 0.000
I74.9 Embolism and thrombosis of unspecified artery
0.682 0.318 0.000
I74.8 Embolism and thrombosis of other arteries
0.682 0.318 0.000
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.682 0.318 0.000
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.682 0.318 0.000
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.682 0.318 0.000
I74.0 Embolism and thrombosis of abdominal aorta
0.682 0.318 0.000
I73.8 Other specified peripheral vascular diseases
0.682 0.318 0.000
I73.1 Thromboangiitis obliterans [Buerger]
0.682 0.318 0.000
M31.6 Other giant cell arteritis
0.681 0.319 0.000
H27 Other disorders of lens
0.681 0.319 0.000
M65-M68 Disorders of synovium and tendon
0.681 0.319 0.000
I62 Other nontraumatic intracranial haemorrhage
0.680 0.320 0.000
R23 Other skin changes
0.680 0.320 0.000
M23.5 Chronic instability of knee
0.680 0.320 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.679 0.321 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.679 0.321 0.000
D63 Anaemia in chronic diseases classified elsewhere
0.679 0.321 0.000
T83.3 Mechanical complication of intra-uterine contraceptive device
0.678 0.322 0.000
I42 Cardiomyopathy
0.677 0.322 0.000
M23.24 Derangement of meniscus due to old tear or injury (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.677 0.323 0.000
C79.5 Secondary malignant neoplasm of bone and bone marrow
0.676 0.324 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.675 0.324 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.675 0.325 0.000
E10.3 With ophthalmic complications
0.673 0.327 0.000
M22.2 Patellofemoral disorders
0.672 0.327 0.000
I51.9 Heart disease, unspecified
0.672 0.328 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.672 0.328 0.000
I69.8 Sequelae of other and unspecified cerebrovascular diseases
0.672 0.328 0.000
I95.2 Hypotension due to drugs
0.671 0.329 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.671 0.329 0.000
H33.3 Retinal breaks without detachment
0.671 0.329 0.000
T86.0 Bone-marrow transplant rejection
0.670 0.329 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.670 0.330 0.000
R41.8 Other and unspecified symptoms and signs involving cognitive functions and awareness
0.669 0.331 0.000
G82 Paraplegia and tetraplegia
0.668 0.332 0.000
I35.8 Other aortic valve disorders
0.668 0.332 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.668 0.332 0.000
D75.1 Secondary polycythaemia
0.668 0.332 0.000
I10 Essential (primary) hypertension
0.667 0.333 0.000
S50 Superficial injury of forearm
0.667 0.333 0.000
R72 Abnormality of white blood cells, not elsewhere classified
0.667 0.333 0.000
S72.00 Fracture of neck of femur (closed)
0.667 0.333 0.000
I71.8 Aortic aneurysm of unspecified site, ruptured
0.665 0.335 0.000
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.665 0.335 0.000
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.665 0.335 0.000
I71.3 Abdominal aortic aneurysm, ruptured
0.665 0.335 0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.665 0.335 0.000
I71.1 Thoracic aortic aneurysm, ruptured
0.665 0.335 0.000
S00-S09 Injuries to the head
0.665 0.335 0.000
M06 Other rheumatoid arthritis
0.665 0.335 0.000
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands
0.664 0.335 0.000
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system
0.664 0.335 0.000
D42 Neoplasm of uncertain or unknown behaviour of meninges
0.664 0.335 0.000
D40 Neoplasm of uncertain or unknown behaviour of male genital organs
0.664 0.335 0.000
D39 Neoplasm of uncertain or unknown behaviour of female genital organs
0.664 0.335 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.664 0.336 0.000
E34 Other endocrine disorders
0.664 0.336 0.000
E32 Diseases of thymus
0.664 0.336 0.000
E31 Polyglandular dysfunction
0.664 0.336 0.000
E30 Disorders of puberty, not elsewhere classified
0.664 0.336 0.000
E29 Testicular dysfunction
0.664 0.336 0.000
E28 Ovarian dysfunction
0.664 0.336 0.000
E26 Hyperaldosteronism
0.664 0.336 0.000
E25 Adrenogenital disorders
0.664 0.336 0.000
E20 Hypoparathyroidism
0.664 0.336 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.664 0.336 0.000
E78.0 Pure hypercholesterolaemia
0.663 0.337 0.000
R73 Elevated blood glucose level
0.663 0.337 0.000
M23.9 Internal derangement of knee, unspecified
0.663 0.337 0.000
M23.6 Other spontaneous disruption of ligament(s) of knee
0.663 0.337 0.000
M23.1 Discoid meniscus (congenital)
0.663 0.337 0.000
M23.0 Cystic meniscus
0.663 0.337 0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs
0.662 0.338 0.000
D47.2 Monoclonal gammopathy
0.662 0.338 0.000
I69.0 Sequelae of subarachnoid haemorrhage
0.661 0.339 0.000
E83 Disorders of mineral metabolism
0.661 0.339 0.000
M35 Other systemic involvement of connective tissue
0.660 0.340 0.000
G83 Other paralytic syndromes
0.660 0.340 0.000
G93 Other disorders of brain
0.659 0.341 0.000
T82.1 Mechanical complication of cardiac electronic device
0.659 0.341 0.000
S52.5 Fracture of lower end of radius
0.658 0.342 0.000
E10.1 With ketoacidosis
0.658 0.342 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.657 0.342 0.000
I35.1 Aortic (valve) insufficiency
0.657 0.343 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.656 0.344 0.000
Y35-Y36 Legal intervention and operations of war
0.656 0.344 0.000
Y10-Y34 Event of undetermined intent
0.656 0.344 0.000
Y00-Y09 Assault
0.656 0.344 0.000
X85-X99 Assault
0.656 0.344 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.656 0.344 0.000
X50-X57 Overexertion, travel and privation
0.656 0.344 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.656 0.344 0.000
X30-X39 Exposure to forces of nature
0.656 0.344 0.000
X20-X29 Contact with venomous animals and plants
0.656 0.344 0.000
X10-X19 Contact with heat and hot substances
0.656 0.344 0.000
X00-X09 Exposure to smoke, fire and flames
0.656 0.344 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.656 0.344 0.000
W75-W84 Other accidental threats to breathing
0.656 0.344 0.000
W65-W74 Accidental drowning and submersion
0.656 0.344 0.000
W50-W64 Exposure to animate mechanical forces
0.656 0.344 0.000
V98-V99 Other and unspecified transport accidents
0.656 0.344 0.000
V95-V97 Air and space transport accidents
0.656 0.344 0.000
V90-V94 Water transport accidents
0.656 0.344 0.000
V80-V89 Other land transport accidents
0.656 0.344 0.000
V70-V79 Bus occupant injured in transport accident
0.656 0.344 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.656 0.344 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.656 0.344 0.000
V40-V49 Car occupant injured in transport accident
0.656 0.344 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.656 0.344 0.000
V20-V29 Motorcycle rider injured in transport accident
0.656 0.344 0.000
V01-V09 Pedestrian injured in transport accident
0.656 0.344 0.000
H57 Other disorders of eye and adnexa
0.655 0.344 0.000
C61 Malignant neoplasm of prostate
0.655 0.345 0.000
D47.1 Chronic myeloproliferative disease
0.655 0.345 0.000
M24.9 Joint derangement, unspecified
0.655 0.345 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.655 0.345 0.000
M24.7 Protrusio acetabuli
0.655 0.345 0.000
M24.6 Ankylosis of joint
0.655 0.345 0.000
M24.5 Contracture of joint
0.655 0.345 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.655 0.345 0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified
0.655 0.345 0.000
Y83 Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.654 0.346 0.000
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs
0.654 0.346 0.000
I09 Other rheumatic heart diseases
0.651 0.349 0.000
I06 Rheumatic aortic valve diseases
0.651 0.349 0.000
I35.0 Aortic (valve) stenosis
0.651 0.349 0.000
M23.29 Derangement of meniscus due to old tear or injury (Unspecified ligament or Unspecified meniscus)
0.650 0.350 0.000
M23.27 Derangement of meniscus due to old tear or injury-Capsular
0.650 0.350 0.000
T83.5 Infection and inflammatory reaction due to prosthetic device, implant and graft in urinary system
0.650 0.350 0.000
R39.2 Extrarenal uraemia
0.650 0.350 0.000
R39.0 Extravasation of urine
0.650 0.350 0.000
E14.8 With unspecified complications
0.649 0.351 0.000
E14.7 With multiple complications
0.649 0.351 0.000
E14.6 With other specified complications
0.649 0.351 0.000
E14.5 With peripheral circulatory complications
0.649 0.351 0.000
E14.4 With neurological complications
0.649 0.351 0.000
E14.2 Withrenal complications
0.649 0.351 0.000
E14.1 With ketoacidosis
0.649 0.351 0.000
E14.0 With coma
0.649 0.351 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.648 0.352 0.000
I69.3 Sequelae of cerebral infarction
0.648 0.352 0.000
C34 Malignant neoplasm of bronchus and lung
0.647 0.353 0.000
C76 Malignant neoplasm of other and ill-defined sites
0.647 0.353 0.000
S20 Superficial injury of thorax
0.645 0.355 0.000
C77.3 Axillary and upper limb lymph nodes
0.645 0.355 0.000
S51 Open wound of forearm
0.644 0.356 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.644 0.356 0.000
Chapter XI Diseases of the digestive system
0.643 0.357 0.000
K57.9 Diverticular disease of intestine, part unspecified, without perforation or abscess
0.643 0.357 0.000
H28 Cataract and other disorders of lens in diseases classified elsewhere
0.642 0.358 0.000
K57 Diverticular disease of intestine
0.641 0.359 0.000
R26.2 Difficulty in walking, not elsewhere classified
0.641 0.359 0.000
I61.9 Intracerebral haemorrhage, unspecified
0.640 0.360 0.000
K55-K64 Other diseases of intestines
0.639 0.361 0.000
R35 Polyuria
0.638 0.362 0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.637 0.363 0.000
D74 Methaemoglobinaemia
0.637 0.363 0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.637 0.363 0.000
D71 Functional disorders of polymorphonuclear neutrophils
0.637 0.363 0.000
R40.2 Coma, unspecified
0.637 0.363 0.000
S42.1 Fracture of scapula
0.636 0.364 0.000
M41 Scoliosis
0.636 0.364 0.000
H43 Disorders of vitreous body
0.635 0.365 0.000
C80.0 Malignant neoplasm, primary site unknown, so stated
0.635 0.365 0.000
Q80-Q89 Other congenital malformations
0.635 0.365 0.000
M24.27 Disorder of ligament (Ankle and foot)
0.635 0.365 0.000
M23.25 Derangement of meniscus due to old tear or injury (Posterior horn of lateral meniscus)
0.635 0.365 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.634 0.366 0.000
C79.2 Secondary malignant neoplasm of skin
0.634 0.366 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.633 0.367 0.000
T82.5 Mechanical complication of other cardiac and vascular devices and implants
0.632 0.368 0.000
S48 Traumatic amputation of shoulder and upper arm
0.632 0.368 0.000
S46 Injury of muscle and tendon at shoulder and upper arm level
0.632 0.368 0.000
S45 Injury of blood vessels at shoulder and upper arm level
0.632 0.368 0.000
S44 Injury of nerves at shoulder and upper arm level
0.632 0.368 0.000
S41 Open wound of shoulder and upper arm
0.632 0.368 0.000
S40 Superficial injury of shoulder and upper arm
0.632 0.368 0.000
S47 Crushing injury of shoulder and upper arm
0.632 0.368 0.000
Q60-Q64 Congenital malformations of the urinary system
0.632 0.368 0.000
H18 Other disorders of cornea
0.631 0.369 0.000
C50.4 Upper-outer quadrant of breast
0.631 0.369 0.000
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.631 0.369 0.000
I99 Other and unspecified disorders of circulatory system
0.631 0.369 0.000
S79 Other and unspecified injuries of hip and thigh
0.631 0.369 0.000
S78 Traumatic amputation of hip and thigh
0.631 0.369 0.000
S77 Crushing injury of hip and thigh
0.631 0.369 0.000
S76 Injury of muscle and tendon at hip and thigh level
0.631 0.369 0.000
S75 Injury of blood vessels at hip and thigh level
0.631 0.369 0.000
S74 Injury of nerves at hip and thigh level
0.631 0.369 0.000
S73 Dislocation, sprain and strain of joint and ligaments of hip
0.631 0.369 0.000
S71 Open wound of hip and thigh
0.631 0.369 0.000
S70 Superficial injury of hip and thigh
0.631 0.369 0.000
V18 Pedal cyclist injured in noncollision transport accident
0.630 0.370 0.000
M22.1 Recurrent subluxation of patella
0.629 0.370 0.000
M22.9 Disorder of patella, unspecified
0.629 0.370 0.000
M22.3 Other derangements of patella
0.629 0.370 0.000
M22.0 Recurrent dislocation of patella
0.629 0.370 0.000
C50.6 Axillary tail of breast
0.629 0.371 0.000
C50.0 Nipple and areola
0.629 0.371 0.000
Y43 Primarily systemic agents
0.629 0.371 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.629 0.371 0.000
G80 Infantile cerebral palsy
0.629 0.371 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.628 0.371 0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.628 0.372 0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.627 0.373 0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.626 0.374 0.000
T83.1 Mechanical complication of other urinary devices and implants
0.626 0.374 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.625 0.375 0.000
D61 Other aplastic anaemias
0.625 0.375 0.000
E55 Vitamin D deficiency
0.624 0.376 0.000
Y40 Systemic antibiotics
0.623 0.377 0.000
S59 Other and unspecified injuries of forearm
0.623 0.377 0.000
S58 Traumatic amputation of forearm
0.623 0.377 0.000
S57 Crushing injury of forearm
0.623 0.377 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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