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Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs77496368
log Bayes Factor = 12.4165
Chromosome 3   position 122,923,739  (GRCh37) Explore rs77496368 on Ensembl!
Variant rs77496368 is part of Cluster X0030

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter II Neoplasms
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
I10-I15 Hypertensive diseases
0.997 0.003 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.997 0.003 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.996 0.004 0.000
E70-E90 Metabolic disorders
0.996 0.004 0.000
I10 Essential (primary) hypertension
0.995 0.005 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.992 0.008 0.000
C15-C26 Malignant neoplasms of digestive organs
0.988 0.012 0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs
0.981 0.019 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.981 0.019 0.000
Chapter VII Diseases of the eye and adnexa
0.978 0.022 0.000
M70-M79 Other soft tissue disorders
0.976 0.024 0.000
E10-E14 Diabetes mellitus
0.974 0.026 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.972 0.028 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.965 0.035 0.000
Chapter VIII Diseases of the ear and mastoid process
0.961 0.039 0.000
I60-I69 Cerebrovascular diseases
0.961 0.039 0.000
S80-S89 Injuries to the knee and lower leg
0.958 0.042 0.000
E11 Non-insulin-dependent diabetes mellitus
0.944 0.056 0.000
C34 Malignant neoplasm of bronchus and lung
0.944 0.056 0.000
I05-I09 Chronic rheumatic heart diseases
0.939 0.061 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.936 0.064 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.930 0.070 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.926 0.074 0.000
C34.1 Upper lobe, bronchus or lung
0.920 0.080 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.920 0.080 0.000
S00-S09 Injuries to the head
0.918 0.082 0.000
M75 Shoulder lesions
0.918 0.082 0.000
C19 Malignant neoplasm of rectosigmoid junction
0.916 0.084 0.000
Chapter XI Diseases of the digestive system
0.914 0.086 0.000
Chapter VI Diseases of the nervous system
0.913 0.087 0.000
K00-K14 Diseases of oral cavity, salivary glands and jaws
0.910 0.090 0.000
E87.5 Hyperkalaemia
0.910 0.090 0.000
E11.9 Without complications
0.908 0.092 0.000
C18 Malignant neoplasm of colon
0.906 0.094 0.000
L03 Cellulitis
0.906 0.094 0.000
M65-M68 Disorders of synovium and tendon
0.903 0.097 0.000
C78.0 Secondary malignant neoplasm of lung
0.902 0.098 0.000
D45 Polycythaemia vera
0.899 0.101 0.000
M45-M49 Spondylopathies
0.898 0.102 0.000
C79 Secondary malignant neoplasm of other sites
0.897 0.103 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.890 0.110 0.000
E20-E35 Disorders of other endocrine glands
0.888 0.112 0.000
I67 Other cerebrovascular diseases
0.888 0.112 0.000
E83 Disorders of mineral metabolism
0.887 0.113 0.000
S60-S69 Injuries to the wrist and hand
0.883 0.117 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.879 0.121 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.874 0.126 0.000
E87.2 Acidosis
0.871 0.129 0.000
C78.7 Secondary malignant neoplasm of liver
0.869 0.131 0.000
I08 Multiple valve diseases
0.868 0.131 0.000
E86 Volume depletion
0.862 0.138 0.000
S09 Other and unspecified injuries of head
0.862 0.138 0.000
I67.9 Cerebrovascular disease, unspecified
0.860 0.140 0.000
H25-H28 Disorders of lens
0.860 0.140 0.000
E87.1 Hypo-osmolality and hyponatraemia
0.859 0.141 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.858 0.142 0.000
K70-K77 Diseases of liver
0.856 0.144 0.000
E87.0 Hyperosmolality and hypernatraemia
0.856 0.144 0.000
H53-H54 Visual disturbances and blindness
0.849 0.151 0.000
L02 Cutaneous abscess, furuncle and carbuncle
0.847 0.153 0.000
C78.8 Secondary malignant neoplasm of other and unspecified digestive organs
0.845 0.155 0.000
S80 Superficial injury of lower leg
0.845 0.155 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.844 0.156 0.000
M65 Synovitis and tenosynovitis
0.844 0.156 0.000
K11 Diseases of salivary glands
0.843 0.156 0.000
K13 Other diseases of lip and oral mucosa
0.842 0.158 0.000
T79-T79 Certain early complications of trauma
0.841 0.159 0.000
H60-H62 Diseases of external ear
0.838 0.162 0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee
0.837 0.163 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.835 0.164 0.000
T84.1 Mechanical complication of internal fixation device of bones of limb
0.835 0.165 0.000
C16 Malignant neoplasm of stomach
0.829 0.171 0.000
K08 Other disorders of teeth and supporting structures
0.828 0.172 0.000
M75.0 Adhesive capsulitis of shoulder
0.827 0.173 0.000
H30-H36 Disorders of choroid and retina
0.826 0.174 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.824 0.175 0.000
C18.9 Colon, unspecified
0.824 0.176 0.000
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites
0.823 0.177 0.000
C51-C58 Malignant neoplasms of female genital organs
0.822 0.178 0.000
S09.9 Unspecified injury of head
0.822 0.178 0.000
K14 Diseases of tongue
0.821 0.179 0.000
G90-G99 Other disorders of the nervous system
0.817 0.183 0.000
H26 Other cataract
0.817 0.183 0.000
M47 Spondylosis
0.815 0.185 0.000
E27 Other disorders of adrenal gland
0.814 0.186 0.000
E11.5 With peripheral circulatory complications
0.813 0.187 0.000
H65-H75 Diseases of middle ear and mastoid
0.811 0.189 0.000
E83.1 Disorders of iron metabolism
0.808 0.192 0.000
C18.2 Ascending colon
0.806 0.194 0.000
I08.0 Disorders of both mitral and aortic valves
0.806 0.194 0.000
M79.0 Rheumatism, unspecified
0.804 0.196 0.000
C78.6 Secondary malignant neoplasm of retroperitoneum and peritoneum
0.804 0.196 0.000
H80-H83 Diseases of inner ear
0.801 0.199 0.000
I64 Stroke, not specified as haemorrhage or infarction
0.800 0.200 0.000
H53 Visual disturbances
0.798 0.202 0.000
C34.9 Bronchus or lung, unspecified
0.797 0.203 0.000
K74 Fibrosis and cirrhosis of liver
0.797 0.203 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.796 0.204 0.000
C15 Malignant neoplasm of oesophagus
0.796 0.204 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.795 0.205 0.000
E10 Insulin-dependent diabetes mellitus
0.791 0.209 0.000
M40-M43 Deforming dorsopathies
0.791 0.209 0.000
I63 Cerebral infarction
0.790 0.210 0.000
H35 Other retinal disorders
0.790 0.210 0.000
L08 Other local infections of skin and subcutaneous tissue
0.787 0.213 0.000
M05-M14 Inflammatory polyarthropathies
0.786 0.214 0.000
K13.7 Other and unspecified lesions of oral mucosa
0.784 0.216 0.000
C20 Malignant neoplasm of rectum
0.783 0.217 0.000
C32 Malignant neoplasm of larynx
0.782 0.218 0.000
D60-D64 Aplastic and other anaemias
0.781 0.219 0.000
H26.9 Cataract, unspecified
0.780 0.220 0.000
L03.1 Cellulitis of other parts of limb
0.780 0.220 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.779 0.221 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.779 0.221 0.000
C79.7 Secondary malignant neoplasm of adrenal gland
0.777 0.223 0.000
I61 Intracerebral haemorrhage
0.776 0.224 0.000
E13 Other specified diabetes mellitus
0.776 0.224 0.000
H52 Disorders of refraction and accommodation
0.774 0.226 0.000
S81 Open wound of lower leg
0.774 0.226 0.000
E50-E64 Other nutritional deficiencies
0.774 0.226 0.000
M65.3 Trigger finger
0.772 0.228 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.771 0.229 0.000
Chapter XXII Codes for special purposes
0.770 0.230 0.000
M47.8 Other spondylosis
0.769 0.231 0.000
S10-S19 Injuries to the neck
0.769 0.231 0.000
H90-H95 Other disorders of ear
0.768 0.232 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.767 0.233 0.000
M72 Fibroblastic disorders
0.766 0.234 0.000
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.765 0.234 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.765 0.235 0.000
L03.8 Cellulitis of other sites
0.764 0.236 0.000
K07 Dentofacial anomalies [including malocclusion]
0.763 0.237 0.000
C64-C68 Malignant neoplasms of urinary tract
0.761 0.239 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.760 0.240 0.000
C79.6 Secondary malignant neoplasm of ovary
0.759 0.240 0.000
I12 Hypertensive renal disease
0.758 0.242 0.000
E11.1 With ketoacidosis
0.758 0.242 0.000
K65-K67 Diseases of peritoneum
0.756 0.244 0.000
K11.2 Sialoadenitis
0.754 0.246 0.000
C26 Malignant neoplasm of other and ill-defined digestive organs
0.753 0.247 0.000
K35-K38 Diseases of appendix
0.753 0.247 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.753 0.247 0.000
C78.2 Secondary malignant neoplasm of pleura
0.752 0.248 0.000
L03.3 Cellulitis of trunk
0.751 0.249 0.000
H60 Otitis externa
0.750 0.250 0.000
I05 Rheumatic mitral valve diseases
0.750 0.250 0.000
M86-M90 Other osteopathies
0.748 0.252 0.000
M47.82 Other spondylosis (Cervical region)
0.747 0.253 0.000
M80-M85 Disorders of bone density and structure
0.746 0.253 0.000
D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs
0.745 0.255 0.000
K10 Other diseases of jaws
0.743 0.257 0.000
S62 Fracture at wrist and hand level
0.743 0.257 0.000
M75.4 Impingement syndrome of shoulder
0.743 0.257 0.000
S70-S79 Injuries to the hip and thigh
0.742 0.258 0.000
L03.9 Cellulitis, unspecified
0.742 0.258 0.000
S83.2 Tear of meniscus, current
0.740 0.260 0.000
M75.3 Calcific tendinitis of shoulder
0.738 0.262 0.000
L50-L54 Urticaria and erythema
0.737 0.263 0.000
S69 Other and unspecified injuries of wrist and hand
0.736 0.264 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.735 0.265 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.734 0.266 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.733 0.267 0.000
S20-S29 Injuries to the thorax
0.733 0.267 0.000
L02.2 Cutaneous abscess, furuncle and carbuncle of trunk
0.733 0.267 0.000
H50 Other strabismus
0.732 0.268 0.000
C16.0 Cardia
0.731 0.269 0.000
S89 Other and unspecified injuries of lower leg
0.730 0.269 0.000
S80.0 Contusion of knee
0.729 0.270 0.000
T79 Certain early complications of trauma, not elsewhere classified
0.729 0.271 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.728 0.272 0.000
L03.0 Cellulitis of finger and toe
0.727 0.273 0.000
L02.1 Cutaneous abscess, furuncle and carbuncle of neck
0.727 0.273 0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.727 0.273 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.726 0.274 0.000
M91-M94 Chondropathies
0.725 0.275 0.000
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts
0.725 0.275 0.000
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.724 0.276 0.000
M77 Other enthesopathies
0.722 0.277 0.000
M45 Ankylosing spondylitis
0.723 0.277 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.722 0.278 0.000
M65.34 Trigger finger-Hand
0.722 0.278 0.000
H18 Other disorders of cornea
0.721 0.279 0.000
H35.0 Background retinopathy and retinal vascular changes
0.721 0.279 0.000
K74.6 Other and unspecified cirrhosis of liver
0.721 0.279 0.000
E80.4 Gilbert's syndrome
0.721 0.279 0.000
D50-D53 Nutritional anaemias
0.720 0.280 0.000
E11.2 With renal complications
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.717 0.283 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.717 0.283 0.000
Chapter I Certain infectious and parasitic diseases
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
E40-E46 Malnutrition
0.717 0.283 0.000
D39 Neoplasm of uncertain or unknown behaviour of female genital organs
0.717 0.283 0.000
I15 Secondary hypertension
0.715 0.285 0.000
I13 Hypertensive heart and renal disease
0.715 0.285 0.000
M60-M63 Disorders of muscles
0.715 0.285 0.000
M00-M03 Infectious arthropathies
0.715 0.285 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.715 0.285 0.000
T33-T35 Frostbite
0.714 0.286 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.714 0.286 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.714 0.286 0.000
T00-T07 Injuries involving multiple body regions
0.714 0.286 0.000
E85 Amyloidosis
0.714 0.286 0.000
E84 Cystic fibrosis
0.714 0.286 0.000
E79 Disorders of purine and pyrimidine metabolism
0.714 0.286 0.000
E77 Disorders of glycoprotein metabolism
0.714 0.286 0.000
E76 Disorders of glycosaminoglycan metabolism
0.714 0.286 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.714 0.286 0.000
E74 Other disorders of carbohydrate metabolism
0.714 0.286 0.000
E73 Lactose intolerance
0.714 0.286 0.000
E72 Other disorders of amino-acid metabolism
0.714 0.286 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.714 0.286 0.000
E70 Disorders of aromatic amino-acid metabolism
0.714 0.286 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.714 0.286 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.712 0.287 0.000
T66-T78 Other and unspecified effects of external causes
0.712 0.288 0.000
C76 Malignant neoplasm of other and ill-defined sites
0.711 0.288 0.000
C79.0 Secondary malignant neoplasm of kidney and renal pelvis
0.711 0.289 0.000
E88 Other metabolic disorders
0.709 0.290 0.000
I86 Varicose veins of other sites
0.709 0.291 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.708 0.291 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.708 0.292 0.000
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.708 0.292 0.000
C21 Malignant neoplasm of anus and anal canal
0.708 0.292 0.000
C17 Malignant neoplasm of small intestine
0.708 0.292 0.000
C23 Malignant neoplasm of gallbladder
0.708 0.292 0.000
C78.5 Secondary malignant neoplasm of large intestine and rectum
0.708 0.292 0.000
S02 Fracture of skull and facial bones
0.708 0.292 0.000
H53.8 Other visual disturbances
0.708 0.292 0.000
I08.1 Disorders of both mitral and tricuspid valves
0.708 0.292 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.707 0.293 0.000
S90-S99 Injuries to the ankle and foot
0.707 0.293 0.000
L08.9 Local infection of skin and subcutaneous tissue, unspecified
0.706 0.293 0.000
I07 Rheumatic tricuspid valve diseases
0.706 0.294 0.000
M79.09 Rheumatism, unspecified (Site unspecified)
0.706 0.294 0.000
I11 Hypertensive heart disease
0.704 0.296 0.000
C78.4 Secondary malignant neoplasm of small intestine
0.703 0.297 0.000
C78.3 Secondary malignant neoplasm of other and unspecified respiratory organs
0.703 0.297 0.000
C78.1 Secondary malignant neoplasm of mediastinum
0.703 0.297 0.000
E87.4 Mixed disorder of acid-base balance
0.703 0.297 0.000
E87.3 Alkalosis
0.703 0.297 0.000
H81 Disorders of vestibular function
0.703 0.297 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.703 0.297 0.000
S82 Fracture of lower leg, including ankle
0.703 0.297 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.701 0.299 0.000
D80-D89 Certain disorders involving the immune mechanism
0.701 0.299 0.000
M65.9 Synovitis and tenosynovitis, unspecified
0.701 0.299 0.000
T84.4 Mechanical complication of other internal orthopaedic devices, imnplants and grafts
0.700 0.300 0.000
M76 Enthesopathies of lower limb, excluding foot
0.700 0.300 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.700 0.300 0.000
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.699 0.301 0.000
S65 Injury of blood vessels at wrist and hand level
0.698 0.301 0.000
E12 Malnutrition-related diabetes mellitus
0.698 0.302 0.000
T87 Complications peculiar to reattachment and amputation
0.698 0.302 0.000
C18.3 Hepatic flexure
0.698 0.302 0.000
H55-H59 Other disorders of eye and adnexa
0.698 0.302 0.000
G70-G73 Diseases of myoneural junction and muscle
0.698 0.302 0.000
I87 Other disorders of veins
0.697 0.303 0.000
C39 Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs
0.697 0.303 0.000
C38 Malignant neoplasm of heart, mediastinum and pleura
0.697 0.303 0.000
C31 Malignant neoplasm of accessory sinuses
0.697 0.303 0.000
C30 Malignant neoplasm of nasal cavity and middle ear
0.697 0.303 0.000
C37 Malignant neoplasm of thymus
0.697 0.303 0.000
C33 Malignant neoplasm of trachea
0.697 0.303 0.000
C79.3 Secondary malignant neoplasm of brain and cerebral meninges
0.697 0.303 0.000
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level
0.695 0.305 0.000
C34.0 Main bronchus
0.695 0.305 0.000
S67 Crushing injury of wrist and hand
0.694 0.306 0.000
K09 Cysts of oral region, not elsewhere classified
0.693 0.307 0.000
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands
0.692 0.308 0.000
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system
0.692 0.308 0.000
D42 Neoplasm of uncertain or unknown behaviour of meninges
0.692 0.308 0.000
D40 Neoplasm of uncertain or unknown behaviour of male genital organs
0.692 0.308 0.000
C80 Malignant neoplasm without specification of site
0.691 0.309 0.000
K11.5 Sialolithiasis
0.691 0.309 0.000
I67.1 Cerebral aneurysm, nonruptured
0.690 0.310 0.000
G93 Other disorders of brain
0.689 0.311 0.000
Chapter XX External causes of morbidity and mortality
0.689 0.311 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.689 0.311 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.689 0.311 0.000
M75.5 Bursitis of shoulder
0.689 0.311 0.000
H27 Other disorders of lens
0.687 0.313 0.000
S88 Traumatic amputation of lower leg
0.687 0.313 0.000
S87 Crushing injury of lower leg
0.687 0.313 0.000
S86 Injury of muscle and tendon at lower leg level
0.687 0.313 0.000
S85 Injury of blood vessels at lower leg level
0.687 0.313 0.000
S84 Injury of nerves at lower leg level
0.687 0.313 0.000
K08.3 Retained dental root
0.687 0.313 0.000
H35.4 Peripheral retinal degeneration
0.687 0.313 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.686 0.314 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.686 0.314 0.000
C79.8 Secondary malignant neoplasm of other specified sites
0.685 0.315 0.000
K72 Hepatic failure, not elsewhere classified
0.685 0.315 0.000
D63 Anaemia in chronic diseases classified elsewhere
0.685 0.315 0.000
K14.9 Disease of tongue, unspecified
0.684 0.316 0.000
D41 Neoplasm of uncertain or unknown behaviour of urinary organs
0.684 0.316 0.000
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts
0.683 0.316 0.000
H10-H13 Disorders of conjunctiva
0.683 0.317 0.000
C52 Malignant neoplasm of vagina
0.683 0.317 0.000
E10.1 With ketoacidosis
0.682 0.318 0.000
M79.00 Rheumatism, unspecified (Multiple sites)
0.682 0.318 0.000
M46 Other inflammatory spondylopathies
0.681 0.319 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.678 0.322 0.000
E24 Cushing's syndrome
0.678 0.322 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.677 0.323 0.000
M10 Gout
0.677 0.323 0.000
E11.8 With unspecified complications
0.677 0.323 0.000
E11.7 With multiple complications
0.677 0.323 0.000
E11.6 With other specified complications
0.677 0.323 0.000
E11.0 With coma
0.677 0.323 0.000
C34.8 Overlapping lesion of bronchus and lung
0.677 0.323 0.000
C34.2 Middle lobe, bronchus or lung
0.677 0.323 0.000
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs
0.676 0.324 0.000
E83.5 Disorders of calcium metabolism
0.676 0.324 0.000
C18.6 Descending colon
0.676 0.324 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.675 0.325 0.000
A30-A49 Other bacterial diseases
0.675 0.325 0.000
E11.4 With neurological complications
0.674 0.326 0.000
I09 Other rheumatic heart diseases
0.673 0.327 0.000
I06 Rheumatic aortic valve diseases
0.673 0.327 0.000
K14.8 Other diseases of tongue
0.673 0.327 0.000
M96 Postprocedural musculoskeletal disorders, not elsewhere classified
0.672 0.328 0.000
H53.2 Diplopia
0.671 0.329 0.000
L10-L14 Bullous disorders
0.671 0.329 0.000
K08.9 Disorder of teeth and supporting structures, unspecified
0.671 0.329 0.000
H49 Paralytic strabismus
0.670 0.330 0.000
M71 Other bursopathies
0.670 0.330 0.000
G35 Multiple sclerosis
0.669 0.331 0.000
S06 Intracranial injury
0.669 0.331 0.000
E23 Hypofunction and other disorders of pituitary gland
0.669 0.331 0.000
K13.6 Irritative hyperplasia of oral mucosa
0.669 0.331 0.000
M79.7 Fibromyalgia
0.667 0.333 0.000
L04 Acute lymphadenitis
0.667 0.333 0.000
L01 Impetigo
0.667 0.333 0.000
L00 Staphylococcal scalded skin syndrome
0.667 0.333 0.000
D48.7 Other specified sites
0.665 0.335 0.000
H73 Other disorders of tympanic membrane
0.665 0.335 0.000
S66 Injury of muscle and tendon at wrist and hand level
0.664 0.336 0.000
L03.2 Cellulitis of face
0.664 0.336 0.000
Q80-Q89 Other congenital malformations
0.664 0.336 0.000
M75.2 Bicipital tendinitis
0.662 0.338 0.000
T86 Failure and rejection of transplanted organs and tissues
0.660 0.340 0.000
D55-D59 Haemolytic anaemias
0.659 0.341 0.000
S08 Traumatic amputation of part of head
0.658 0.341 0.000
S07 Crushing injury of head
0.658 0.341 0.000
S05 Injury of eye and orbit
0.658 0.341 0.000
S04 Injury of cranial nerves
0.658 0.341 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.658 0.341 0.000
M75.8 Other shoulder lesions
0.658 0.342 0.000
M75.9 Shoulder lesion, unspecified
0.658 0.342 0.000
H20 Iridocyclitis
0.658 0.342 0.000
C50-C50 Malignant neoplasm of breast
0.657 0.343 0.000
S80.1 Contusion of other and unspecified parts of lower leg
0.656 0.344 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.655 0.344 0.000
L60-L75 Disorders of skin appendages
0.655 0.345 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.654 0.346 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.654 0.346 0.000
C15.9 Oesophagus, unspecified
0.653 0.347 0.000
K06 Other disorders of gingiva and edentulous alveolar ridge
0.653 0.347 0.000
K03 Other diseases of hard tissues of teeth
0.653 0.347 0.000
K00 Disorders of tooth development and eruption
0.653 0.347 0.000
G62 Other polyneuropathies
0.652 0.348 0.000
K05 Gingivitis and periodontal diseases
0.652 0.348 0.000
K08.8 Other specified disorders of teeth and supporting structures
0.652 0.348 0.000
S62.5 Fracture of thumb
0.652 0.348 0.000
L05 Pilonidal cyst
0.651 0.349 0.000
K14.0 Glossitis
0.651 0.349 0.000
S81.0 Open wound of knee
0.651 0.349 0.000
M06 Other rheumatoid arthritis
0.650 0.350 0.000
C18.8 Overlapping lesion of colon
0.650 0.350 0.000
C18.5 Splenic flexure
0.650 0.350 0.000
C18.1 Appendix
0.650 0.350 0.000
E27.9 Disorder of adrenal gland, unspecified
0.648 0.352 0.000
C09 Malignant neoplasm of tonsil
0.648 0.352 0.000
G99 Other disorders of nervous system in diseases classified elsewhere
0.648 0.352 0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.647 0.353 0.000
M66 Spontaneous rupture of synovium and tendon
0.647 0.353 0.000
G83 Other paralytic syndromes
0.647 0.353 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.647 0.353 0.000
S01 Open wound of head
0.647 0.353 0.000
H52.3 Anisometropia and aniseikonia
0.646 0.354 0.000
I62 Other nontraumatic intracranial haemorrhage
0.646 0.354 0.000
T82.5 Mechanical complication of other cardiac and vascular devices and implants
0.644 0.356 0.000
C32.9 Larynx, unspecified
0.644 0.356 0.000
E27.1 Primary adrenocortical insufficiency
0.644 0.356 0.000
K37 Unspecified appendicitis
0.644 0.356 0.000
M49 Spondylopathies in diseases classified elsewhere
0.644 0.356 0.000
K75 Other inflammatory liver diseases
0.644 0.356 0.000
I61.9 Intracerebral haemorrhage, unspecified
0.644 0.356 0.000
K11.6 Mucocele of salivary gland
0.644 0.356 0.000
C79.4 Secondary malignant neoplasm of other and unspecified parts of nervous system
0.643 0.357 0.000
C79.1 Secondary malignant neoplasm of bladder and other and unspecified urinary organs
0.643 0.357 0.000
H26.4 After-cataract
0.642 0.357 0.000
C18.7 Sigmoid colon
0.642 0.358 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.642 0.358 0.000
G95 Other diseases of spinal cord
0.640 0.360 0.000
H35.6 Retinal haemorrhage
0.639 0.361 0.000
I60 Subarachnoid haemorrhage
0.639 0.361 0.000
K07.6 Temporomandibular joint disorders
0.639 0.361 0.000
H51 Other disorders of binocular movement
0.638 0.362 0.000
I30-I52 Other forms of heart disease
0.637 0.363 0.000
I63.9 Cerebral infarction, unspecified
0.637 0.363 0.000
T82.1 Mechanical complication of cardiac electronic device
0.637 0.363 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.637 0.363 0.000
E34 Other endocrine disorders
0.637 0.363 0.000
E32 Diseases of thymus
0.637 0.363 0.000
E31 Polyglandular dysfunction
0.637 0.363 0.000
E30 Disorders of puberty, not elsewhere classified
0.637 0.363 0.000
E26 Hyperaldosteronism
0.637 0.363 0.000
E25 Adrenogenital disorders
0.637 0.363 0.000
E22 Hyperfunction of pituitary gland
0.637 0.363 0.000
E20 Hypoparathyroidism
0.637 0.363 0.000
E10.3 With ophthalmic complications
0.637 0.363 0.000
I67.7 Cerebral arteritis, not elsewhere classified
0.636 0.363 0.000
I67.6 Nonpyogenic thrombosis of intracranial venous system
0.636 0.363 0.000
I67.5 Moyamoya disease
0.636 0.363 0.000
I67.4 Hypertensive encephalopathy
0.636 0.363 0.000
I67.3 Progressive vascular leukoencephalopathy
0.636 0.363 0.000
I67.0 Dissection of cerebral arteries, nonruptured
0.636 0.363 0.000
E83.9 Disorder of mineral metabolism, unspecified
0.636 0.364 0.000
E83.8 Other disorders of mineral metabolism
0.636 0.364 0.000
E83.3 Disorders of phosphorus metabolism
0.636 0.364 0.000
E83.2 Disorders of zinc metabolism
0.636 0.364 0.000
E83.0 Disorders of copper metabolism
0.636 0.364 0.000
E27.8 Other specified disorders of adrenal gland
0.635 0.364 0.000
M95 Other acquired deformities of musculoskeletal system and connective tissue
0.635 0.365 0.000
H60.3 Other infective otitis externa
0.635 0.365 0.000
E13.9 Without complications
0.634 0.366 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.633 0.367 0.000
T79.6 Traumatic ischaemia of muscle
0.633 0.367 0.000
Q50-Q56 Congenital malformations of genital organs
0.632 0.368 0.000
T84.2 Mechanical complication of internal fixation device of other bones
0.632 0.368 0.000
E89.2 Postprocedural hypoparathyroidism
0.632 0.368 0.000
M79.8 Other specified soft tissue disorders
0.632 0.368 0.000
H53.9 Visual disturbance, unspecified
0.632 0.368 0.000
C54 Malignant neoplasm of corpus uteri
0.631 0.369 0.000
K74.0 Hepatic fibrosis
0.631 0.369 0.000
K08.1 Loss of teeth due to accident, extraction or local periodontal disease
0.631 0.369 0.000
S69.9 Unspecified injury of wrist and hand
0.631 0.369 0.000
D48.6 Breast
0.631 0.369 0.000
S80.8 Other superficial injuries of lower leg
0.631 0.369 0.000
M20-M25 Other joint disorders
0.631 0.369 0.000
H53.1 Subjective visual disturbances
0.630 0.370 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.630 0.370 0.000
M79.9 Soft tissue disorder, unspecified
0.630 0.370 0.000
M79.4 Hypertrophy of (infrapatellar) fat pad
0.630 0.370 0.000
M79.3 Panniculitis, unspecified
0.630 0.370 0.000
M79.2 Neuralgia and neuritis, unspecified
0.630 0.370 0.000
M79.1 Myalgia
0.630 0.370 0.000
T82.3 Mechanical complication of other vascular grafts
0.629 0.371 0.000
C60-C63 Malignant neoplasms of male genital organs
0.629 0.371 0.000
M47.1 Other spondylosis with myelopathy
0.628 0.372 0.000
S83.5 Sprain and strain involving (anterior)(posterior) cruciate ligament of knee
0.627 0.373 0.000
D46 Myelodysplastic syndromes
0.627 0.373 0.000
D68 Other coagulation defects
0.627 0.373 0.000
T84.9 Unspecified complication of internal orthopaedic prosthetic device, implant and graft
0.626 0.373 0.000
T84.3 Mechanical complication of other bone devices, implants and grafts
0.626 0.373 0.000
E29 Testicular dysfunction
0.626 0.373 0.000
K74.3 Primary biliary cirrhosis
0.626 0.374 0.000
M75.1 Rotator cuff syndrome
0.626 0.374 0.000
E53 Deficiency of other B group vitamins
0.626 0.374 0.000
S82.8 Fractures of other parts of lower leg
0.625 0.374 0.000
D72 Other disorders of white blood cells
0.625 0.375 0.000
C66 Malignant neoplasm of ureter
0.625 0.375 0.000
E14 Unspecified diabetes mellitus
0.624 0.376 0.000
H66 Suppurative and unspecified otitis media
0.623 0.376 0.000
K10.8 Other specified diseases of jaws
0.623 0.377 0.000
H69 Other disorders of Eustachian tube
0.623 0.377 0.000
I08.9 Multiple valve disease, unspecified
0.623 0.377 0.000
I08.8 Other multiple valve diseases
0.623 0.377 0.000
I08.2 Disorders of both aortic and tricuspid valves
0.623 0.377 0.000
H47 Other disorders of optic [2nd] nerve and visual pathways
0.622 0.378 0.000
M79.6 Pain in limb
0.622 0.378 0.000
K90-K93 Other diseases of the digestive system
0.622 0.378 0.000
D48.5 Skin
0.622 0.378 0.000
K70 Alcoholic liver disease
0.621 0.379 0.000
I50 Heart failure
0.620 0.380 0.000
H74 Other disorders of middle ear and mastoid
0.620 0.380 0.000
Q00-Q07 Congenital malformations of the nervous system
0.620 0.380 0.000
K65 Peritonitis
0.620 0.380 0.000
S40-S49 Injuries to the shoulder and upper arm
0.619 0.381 0.000
H92 Otalgia and effusion of ear
0.618 0.381 0.000
D47.3 Essential (haemorrhagic) thrombocythaemia
0.618 0.382 0.000
S09.8 Other specified injuries of head
0.618 0.382 0.000
S09.7 Multiple injuries of head
0.618 0.382 0.000
S09.2 Traumatic rupture of ear drum
0.618 0.382 0.000
S09.1 Injury of muscle and tendon of head
0.618 0.382 0.000
S09.0 Injury of blood vessels of head, not elsewhere classified
0.618 0.382 0.000
A49 Bacterial infection of unspecified site
0.618 0.382 0.000
I86.1 Scrotal varices
0.618 0.382 0.000
I89 Other non-infective disorders of lymphatic vessels and lymph nodes
0.617 0.383 0.000
H28 Cataract and other disorders of lens in diseases classified elsewhere
0.616 0.383 0.000
M72.0 Palmar fascial fibromatosis [Dupuytren]
0.616 0.384 0.000
H52.1 Myopia
0.616 0.384 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.615 0.385 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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