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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs115754869
log Bayes Factor = 17.8128
Chromosome 3   position 152,084,816  (GRCh37) Explore rs115754869 on Ensembl!
Variant rs115754869 is part of Cluster X0039

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
I20-I25 Ischaemic heart diseases
1.000 0.000 0.000
I30-I52 Other forms of heart disease
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.999 0.001 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.998 0.002 0.000
I25 Chronic ischaemic heart disease
0.997 0.003 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.997 0.003 0.000
Chapter VII Diseases of the eye and adnexa
0.996 0.004 0.000
Chapter X Diseases of the respiratory system
0.996 0.004 0.000
I60-I69 Cerebrovascular diseases
0.994 0.006 0.000
H30-H36 Disorders of choroid and retina
0.992 0.008 0.000
Chapter V Mental and behavioural disorders
0.985 0.015 0.000
M50-M54 Other dorsopathies
0.978 0.022 0.000
I20 Angina pectoris
0.975 0.025 0.000
J40-J47 Chronic lower respiratory diseases
0.974 0.026 0.000
S60-S69 Injuries to the wrist and hand
0.972 0.028 0.000
H35 Other retinal disorders
0.969 0.031 0.000
I25.2 Old myocardial infarction
0.967 0.033 0.000
I42 Cardiomyopathy
0.965 0.035 0.000
I21 Acute myocardial infarction
0.965 0.035 0.000
M45-M49 Spondylopathies
0.958 0.042 0.000
I67 Other cerebrovascular diseases
0.955 0.045 0.000
J44 Other chronic obstructive pulmonary disease
0.954 0.046 0.000
I73 Other peripheral vascular diseases
0.954 0.046 0.000
J30-J39 Other diseases of upper respiratory tract
0.945 0.055 0.000
I20.9 Angina pectoris, unspecified
0.945 0.055 0.000
I44 Atrioventricular and left bundle-branch block
0.944 0.056 0.000
Chapter VI Diseases of the nervous system
0.942 0.058 0.000
Chapter VIII Diseases of the ear and mastoid process
0.939 0.061 0.000
M54 Dorsalgia
0.936 0.064 0.000
I25.8 Other forms of chronic ischaemic heart disease
0.933 0.067 0.000
I35 Nonrheumatic aortic valve disorders
0.928 0.072 0.000
I64 Stroke, not specified as haemorrhage or infarction
0.927 0.073 0.000
I73.0 Raynaud's syndrome
0.926 0.074 0.000
I21.9 Acute myocardial infarction, unspecified
0.926 0.074 0.000
I51 Complications and ill-defined descriptions of heart disease
0.922 0.078 0.000
I34 Nonrheumatic mitral valve disorders
0.921 0.079 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.919 0.081 0.000
H34 Retinal vascular occlusions
0.912 0.088 0.000
H90-H95 Other disorders of ear
0.912 0.088 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.907 0.093 0.000
I42.0 Dilated cardiomyopathy
0.906 0.094 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.906 0.094 0.000
Chapter XX External causes of morbidity and mortality
0.906 0.094 0.000
I77 Other disorders of arteries and arterioles
0.904 0.096 0.000
I05-I09 Chronic rheumatic heart diseases
0.903 0.097 0.000
I20.8 Other forms of angina pectoris
0.902 0.098 0.000
J33 Nasal polyp
0.896 0.104 0.000
I74 Arterial embolism and thrombosis
0.890 0.110 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.890 0.110 0.000
H35.8 Other specified retinal disorders
0.881 0.119 0.000
I67.8 Other specified cerebrovascular diseases
0.879 0.121 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.878 0.122 0.000
I67.9 Cerebrovascular disease, unspecified
0.876 0.124 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.875 0.125 0.000
M50 Cervical disk disorders
0.870 0.130 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.865 0.135 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.860 0.140 0.000
I72 Other aneurysm
0.857 0.143 0.000
H34.8 Other retinal vascular occlusions
0.855 0.145 0.000
I44.1 Atrioventricular block, second degree
0.855 0.145 0.000
M46 Other inflammatory spondylopathies
0.852 0.148 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.852 0.148 0.000
I35.2 Aortic (valve) stenosis with insufficiency
0.851 0.149 0.000
I50 Heart failure
0.849 0.151 0.000
S66 Injury of muscle and tendon at wrist and hand level
0.846 0.154 0.000
I25.9 Chronic ischaemic heart disease, unspecified
0.845 0.155 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.845 0.155 0.000
S50-S59 Injuries to the elbow and forearm
0.843 0.157 0.000
I77.9 Disorder of arteries and arterioles, unspecified
0.843 0.157 0.000
T79-T79 Certain early complications of trauma
0.839 0.161 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.839 0.161 0.000
G90-G99 Other disorders of the nervous system
0.838 0.162 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.834 0.166 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.834 0.166 0.000
I25.1 Atherosclerotic heart disease
0.834 0.166 0.000
I08 Multiple valve diseases
0.834 0.166 0.000
M54.5 Low back pain
0.833 0.167 0.000
J44.8 Other specified chronic obstructive pulmonary disease
0.833 0.167 0.000
J44.9 Chronic obstructive pulmonary disease, unspecified
0.829 0.171 0.000
H35.4 Peripheral retinal degeneration
0.829 0.171 0.000
M54.9 Dorsalgia, unspecified
0.829 0.171 0.000
I21.4 Acute subendocardial myocardial infarction
0.828 0.172 0.000
J40 Bronchitis, not specified as acute or chronic
0.827 0.173 0.000
J33.9 Nasal polyp, unspecified
0.826 0.174 0.000
M47 Spondylosis
0.823 0.177 0.000
J90-J94 Other diseases of pleura
0.821 0.179 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.820 0.180 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.820 0.180 0.000
H43-H45 Disorders of vitreous body and globe
0.820 0.180 0.000
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection
0.819 0.181 0.000
I42.9 Cardiomyopathy, unspecified
0.818 0.182 0.000
J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified
0.816 0.184 0.000
I34.0 Mitral (valve) insufficiency
0.815 0.185 0.000
H91 Other hearing loss
0.815 0.185 0.000
I45 Other conduction disorders
0.812 0.188 0.000
I33 Acute and subacute endocarditis
0.809 0.191 0.000
I62 Other nontraumatic intracranial haemorrhage
0.807 0.193 0.000
M40-M43 Deforming dorsopathies
0.807 0.193 0.000
L20-L30 Dermatitis and eczema
0.807 0.193 0.000
S20-S29 Injuries to the thorax
0.806 0.193 0.000
H36 Retinal disorders in diseases classified elsewhere
0.805 0.195 0.000
J30 Vasomotor and allergic rhinitis
0.805 0.195 0.000
S90-S99 Injuries to the ankle and foot
0.802 0.198 0.000
S64 Injury of nerves at wrist and hand level
0.800 0.200 0.000
M70-M79 Other soft tissue disorders
0.799 0.201 0.000
I44.7 Left bundle-branch block, unspecified
0.798 0.202 0.000
F22 Persistent delusional disorders
0.798 0.202 0.000
M20-M25 Other joint disorders
0.797 0.203 0.000
I22 Subsequent myocardial infarction
0.797 0.203 0.000
T39.1 4-Aminophenol derivatives
0.796 0.204 0.000
Chapter XXII Codes for special purposes
0.796 0.204 0.000
I63 Cerebral infarction
0.794 0.205 0.000
H35.6 Retinal haemorrhage
0.792 0.208 0.000
H93 Other disorders of ear, not elsewhere classified
0.792 0.208 0.000
E10-E14 Diabetes mellitus
0.792 0.208 0.000
M05-M14 Inflammatory polyarthropathies
0.790 0.210 0.000
F99-F99 Unspecified mental disorder
0.789 0.210 0.000
M48 Other spondylopathies
0.789 0.211 0.000
J33.8 Other polyp of sinus
0.789 0.211 0.000
I51.8 Other ill-defined heart diseases
0.788 0.212 0.000
I69 Sequelae of cerebrovascular disease
0.788 0.212 0.000
H55-H59 Other disorders of eye and adnexa
0.787 0.213 0.000
J35 Chronic diseases of tonsils and adenoids
0.786 0.214 0.000
M50.0 Cervical disk disorder with myelopathy
0.783 0.217 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.781 0.219 0.000
F30-F39 Mood [affective] disorders
0.781 0.219 0.000
S67 Crushing injury of wrist and hand
0.780 0.219 0.000
M86-M90 Other osteopathies
0.780 0.220 0.000
F20 Schizophrenia
0.778 0.222 0.000
H40-H42 Glaucoma
0.777 0.222 0.000
F80-F89 Disorders of psychological development
0.776 0.224 0.000
H33 Retinal detachments and breaks
0.776 0.224 0.000
M46.9 Inflammatory spondylopathy, unspecified
0.776 0.224 0.000
I70 Atherosclerosis
0.775 0.225 0.000
S60 Superficial injury of wrist and hand
0.773 0.227 0.000
S62 Fracture at wrist and hand level
0.773 0.227 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.772 0.228 0.000
I34.9 Nonrheumatic mitral valve disorder, unspecified
0.768 0.231 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.768 0.232 0.000
S61 Open wound of wrist and hand
0.768 0.232 0.000
S10-S19 Injuries to the neck
0.767 0.233 0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.763 0.237 0.000
H35.3 Degeneration of macula and posterior pole
0.762 0.238 0.000
S00-S09 Injuries to the head
0.762 0.238 0.000
H35.0 Background retinopathy and retinal vascular changes
0.759 0.241 0.000
M53 Other dorsopathies, not elsewhere classified
0.757 0.242 0.000
G35 Multiple sclerosis
0.757 0.243 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.757 0.243 0.000
I71 Aortic aneurysm and dissection
0.755 0.245 0.000
I51.9 Heart disease, unspecified
0.754 0.246 0.000
I21.2 Acute transmural myocardial infarction of other sites
0.752 0.248 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.752 0.248 0.000
M54.99 Dorsalgia, unspecified (Site unspecified)
0.752 0.248 0.000
I49 Other cardiac arrhythmias
0.751 0.249 0.000
J42 Unspecified chronic bronchitis
0.750 0.250 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.749 0.250 0.000
I50.9 Heart failure, unspecified
0.749 0.251 0.000
J81 Pulmonary oedema
0.747 0.253 0.000
I08.1 Disorders of both mitral and tricuspid valves
0.747 0.253 0.000
M54.4 Lumbago with sciatica
0.747 0.253 0.000
J32 Chronic sinusitis
0.746 0.254 0.000
S66.3 Injury of extensor muscle and tendon of other finger at wrist and hand level
0.746 0.254 0.000
H91.9 Hearing loss, unspecified
0.746 0.254 0.000
I51.4 Myocarditis, unspecified
0.745 0.254 0.000
L60-L75 Disorders of skin appendages
0.745 0.255 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.744 0.256 0.000
I35.1 Aortic (valve) insufficiency
0.743 0.257 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.742 0.258 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.742 0.258 0.000
H92 Otalgia and effusion of ear
0.742 0.258 0.000
I20.1 Angina pectoris with documented spasm
0.741 0.259 0.000
S32 Fracture of lumbar spine and pelvis
0.741 0.259 0.000
I74.5 Embolism and thrombosis of iliac artery
0.740 0.260 0.000
I38 Endocarditis, valve unspecified
0.739 0.261 0.000
J43 Emphysema
0.739 0.261 0.000
M65-M68 Disorders of synovium and tendon
0.738 0.262 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.733 0.266 0.000
Chapter II Neoplasms
0.729 0.271 0.000
I25.5 Ischaemic cardiomyopathy
0.729 0.271 0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.727 0.273 0.000
I42.1 Obstructive hypertrophic cardiomyopathy
0.726 0.274 0.000
G63.2 Diabetic polyneuropathy
0.725 0.275 0.000
T79 Certain early complications of trauma, not elsewhere classified
0.724 0.276 0.000
H10-H13 Disorders of conjunctiva
0.724 0.276 0.000
I44.3 Other and unspecified atrioventricular block
0.724 0.276 0.000
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level
0.723 0.277 0.000
H95 Postprocedural disorders of ear and mastoid process, not elsewhere classified
0.723 0.277 0.000
I42.2 Other hypertrophic cardiomyopathy
0.723 0.277 0.000
W00-W19 Falls
0.723 0.277 0.000
Q60-Q64 Congenital malformations of the urinary system
0.722 0.278 0.000
M91-M94 Chondropathies
0.721 0.278 0.000
M45 Ankylosing spondylitis
0.720 0.280 0.000
F22.0 Delusional disorder
0.719 0.281 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.719 0.281 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.719 0.281 0.000
I72.8 Aneurysm of other specified arteries
0.717 0.282 0.000
S40-S49 Injuries to the shoulder and upper arm
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
I23 Certain current complications following acute myocardial infarction
0.717 0.283 0.000
I52 Other heart disorders in diseases classified elsewhere
0.717 0.283 0.000
I48 Atrial fibrillation and flutter
0.717 0.283 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.717 0.283 0.000
I41 Myocarditis in diseases classified elsewhere
0.717 0.283 0.000
I40 Acute myocarditis
0.717 0.283 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.717 0.283 0.000
I37 Pulmonary valve disorders
0.717 0.283 0.000
I36 Nonrheumatic tricuspid valve disorders
0.717 0.283 0.000
I32 Pericarditis in diseases classified elsewhere
0.717 0.283 0.000
I30 Acute pericarditis
0.717 0.283 0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.717 0.283 0.000
V80-V89 Other land transport accidents
0.716 0.284 0.000
T33-T35 Frostbite
0.716 0.284 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.716 0.284 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.716 0.284 0.000
T00-T07 Injuries involving multiple body regions
0.716 0.284 0.000
J31 Chronic rhinitis, nasopharyngitis and pharyngitis
0.716 0.284 0.000
E50-E64 Other nutritional deficiencies
0.716 0.284 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.716 0.284 0.000
M60-M63 Disorders of muscles
0.716 0.284 0.000
M00-M03 Infectious arthropathies
0.716 0.284 0.000
I25.6 Silent myocardial ischaemia
0.715 0.285 0.000
I25.4 Coronary artery aneurysm
0.715 0.285 0.000
I25.3 Aneurysm of heart
0.715 0.285 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.715 0.285 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.715 0.285 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.714 0.286 0.000
M54.2 Cervicalgia
0.714 0.286 0.000
J09-J18 Influenza and pneumonia
0.714 0.286 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.712 0.287 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.712 0.287 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.711 0.289 0.000
H31 Other disorders of choroid
0.711 0.289 0.000
H30 Chorioretinal inflammation
0.711 0.289 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.711 0.289 0.000
I67.2 Cerebral atherosclerosis
0.710 0.290 0.000
J90 Pleural effusion, not elsewhere classified
0.708 0.292 0.000
M25 Other joint disorders, not elsewhere classified
0.707 0.293 0.000
G70-G73 Diseases of myoneural junction and muscle
0.707 0.293 0.000
H93.1 Tinnitus
0.707 0.293 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.706 0.294 0.000
F70-F79 Mental retardation
0.706 0.294 0.000
F60-F69 Disorders of adult personality and behaviour
0.706 0.294 0.000
G93 Other disorders of brain
0.706 0.294 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.705 0.295 0.000
T39.0 Salicylates
0.704 0.295 0.000
S51 Open wound of forearm
0.704 0.296 0.000
J30.1 Allergic rhinitis due to pollen
0.704 0.296 0.000
M47.2 Other spondylosis with radiculopathy
0.703 0.297 0.000
I77.8 Other specified disorders of arteries and arterioles
0.702 0.298 0.000
S68 Traumatic amputation of wrist and hand
0.702 0.298 0.000
I08.0 Disorders of both mitral and aortic valves
0.702 0.298 0.000
G99 Other disorders of nervous system in diseases classified elsewhere
0.701 0.299 0.000
J95-J99 Other diseases of the respiratory system
0.701 0.299 0.000
X60-X84 Intentional self-harm
0.700 0.300 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.699 0.301 0.000
J41 Simple and mucopurulent chronic bronchitis
0.699 0.301 0.000
E70-E90 Metabolic disorders
0.698 0.302 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.698 0.302 0.000
S69 Other and unspecified injuries of wrist and hand
0.697 0.303 0.000
S65 Injury of blood vessels at wrist and hand level
0.697 0.303 0.000
M46.92 Inflammatory spondylopathy, unspecified (Cervical region)
0.697 0.303 0.000
L30 Other dermatitis
0.696 0.304 0.000
H35.9 Retinal disorder, unspecified
0.694 0.305 0.000
H35.7 Separation of retinal layers
0.694 0.305 0.000
H35.5 Hereditary retinal dystrophy
0.694 0.305 0.000
H35.2 Other proliferative retinopathy
0.694 0.305 0.000
H35.1 Retinopathy of prematurity
0.694 0.305 0.000
E10 Insulin-dependent diabetes mellitus
0.694 0.306 0.000
G62 Other polyneuropathies
0.694 0.306 0.000
T31 Burns classified according to extent of body surface involved
0.693 0.307 0.000
I42.8 Other cardiomyopathies
0.692 0.308 0.000
I42.7 Cardiomyopathy due to drugs and other external agents
0.692 0.308 0.000
I42.6 Alcoholic cardiomyopathy
0.692 0.308 0.000
I42.5 Other restrictive cardiomyopathy
0.692 0.308 0.000
I42.4 Endocardial fibroelastosis
0.692 0.308 0.000
I42.3 Endomyocardial (eosinophilic) disease
0.692 0.308 0.000
I21.X Presumed acute myicardial infaction (unconfirmed)
0.692 0.308 0.000
I21.3 Acute transmural myocardial infarction of unspecified site
0.692 0.308 0.000
I21.1 Acute transmural myocardial infarction of inferior wall
0.691 0.309 0.000
I77.6 Arteritis, unspecified
0.690 0.310 0.000
D00-D09 In situ neoplasms
0.689 0.311 0.000
M49 Spondylopathies in diseases classified elsewhere
0.687 0.313 0.000
J45 Asthma
0.687 0.313 0.000
M80-M85 Disorders of bone density and structure
0.685 0.314 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.685 0.315 0.000
I67.7 Cerebral arteritis, not elsewhere classified
0.685 0.315 0.000
I67.6 Nonpyogenic thrombosis of intracranial venous system
0.685 0.315 0.000
I67.5 Moyamoya disease
0.685 0.315 0.000
I67.4 Hypertensive encephalopathy
0.685 0.315 0.000
I67.3 Progressive vascular leukoencephalopathy
0.685 0.315 0.000
I67.0 Dissection of cerebral arteries, nonruptured
0.685 0.315 0.000
M47.9 Spondylosis, unspecified
0.685 0.315 0.000
I73.8 Other specified peripheral vascular diseases
0.684 0.316 0.000
I73.1 Thromboangiitis obliterans [Buerger]
0.684 0.316 0.000
I44.0 Atrioventricular block, first degree
0.683 0.317 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.683 0.317 0.000
I72.4 Aneurysm of artery of lower extremity
0.683 0.317 0.000
I34.1 Mitral (valve) prolapse
0.681 0.319 0.000
H90 Conductive and sensorineural hearing loss
0.681 0.319 0.000
H16 Keratitis
0.679 0.321 0.000
J37 Chronic laryngitis and laryngotracheitis
0.678 0.322 0.000
F01 Vascular dementia
0.677 0.322 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.677 0.322 0.000
S64.4 Injury of digital nerve of other finger
0.677 0.323 0.000
Q50-Q56 Congenital malformations of genital organs
0.677 0.323 0.000
I44.6 Other and unspecified fascicular block
0.677 0.323 0.000
I44.5 Left posterior fascicular block
0.677 0.323 0.000
I44.4 Left anterior fascicular block
0.677 0.323 0.000
M06 Other rheumatoid arthritis
0.676 0.324 0.000
I51.7 Cardiomegaly
0.676 0.324 0.000
L27 Dermatitis due to substances taken internally
0.676 0.324 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.676 0.324 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.676 0.324 0.000
E20-E35 Disorders of other endocrine glands
0.675 0.324 0.000
I35.9 Aortic valve disorder, unspecified
0.675 0.325 0.000
L40-L45 Papulosquamous disorders
0.674 0.325 0.000
S70-S79 Injuries to the hip and thigh
0.674 0.325 0.000
I35.0 Aortic (valve) stenosis
0.674 0.326 0.000
I62.0 Subdural haemorrhage (acute) (nontraumatic)
0.674 0.326 0.000
G30-G32 Other degenerative diseases of the nervous system
0.674 0.326 0.000
J39 Other diseases of upper respiratory tract
0.673 0.326 0.000
I46 Cardiac arrest
0.673 0.326 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.673 0.327 0.000
I33.0 Acute and subacute infective endocarditis
0.673 0.327 0.000
M54.8 Other dorsalgia
0.671 0.329 0.000
M54.6 Pain in thoracic spine
0.671 0.329 0.000
M54.0 Panniculitis affecting regions of neck and back
0.671 0.329 0.000
H36.0 Diabetic retinopathy
0.671 0.329 0.000
I44.2 Atrioventricular block, complete
0.671 0.329 0.000
M35 Other systemic involvement of connective tissue
0.670 0.330 0.000
M54.56 Low back pain (Lumbar region)
0.670 0.330 0.000
M43 Other deforming dorsopathies
0.669 0.331 0.000
H33.3 Retinal breaks without detachment
0.668 0.332 0.000
M48.0 Spinal stenosis
0.668 0.332 0.000
F41 Other anxiety disorders
0.667 0.332 0.000
J46 Status asthmaticus
0.667 0.333 0.000
I50.0 Congestive heart failure
0.667 0.333 0.000
I10-I15 Hypertensive diseases
0.666 0.334 0.000
M51 Other intervertebral disk disorders
0.666 0.334 0.000
V20-V29 Motorcycle rider injured in transport accident
0.666 0.334 0.000
I35.8 Other aortic valve disorders
0.666 0.334 0.000
F33 Recurrent depressive disorder
0.665 0.335 0.000
M54.1 Radiculopathy
0.665 0.335 0.000
Q00-Q07 Congenital malformations of the nervous system
0.664 0.336 0.000
M54.59 Low back pain (Site unspecified)
0.662 0.338 0.000
I51.6 Cardiovascular disease, unspecified
0.661 0.339 0.000
I51.5 Myocardial degeneration
0.661 0.339 0.000
I51.3 Intracardiac thrombosis, not elsewhere classified
0.661 0.339 0.000
I51.2 Rupture of papillary muscle, not elsewhere classified
0.661 0.339 0.000
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.661 0.339 0.000
I51.0 Cardiac septal defect, acquired
0.661 0.339 0.000
I34.8 Other nonrheumatic mitral valve disorders
0.660 0.340 0.000
I34.2 Nonrheumatic mitral (valve) stenosis
0.660 0.340 0.000
H44 Disorders of globe
0.659 0.341 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.659 0.341 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.659 0.341 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.659 0.341 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.659 0.341 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.659 0.341 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.659 0.341 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.659 0.341 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.659 0.341 0.000
T36 Poisoning by systemic antibiotics
0.659 0.341 0.000
V10-V19 Pedal cyclist injured in transport accident
0.659 0.341 0.000
J93 Pneumothorax
0.658 0.342 0.000
I63.8 Other cerebral infarction
0.656 0.344 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.656 0.344 0.000
S09 Other and unspecified injuries of head
0.655 0.345 0.000
I61 Intracerebral haemorrhage
0.655 0.345 0.000
D50-D53 Nutritional anaemias
0.654 0.346 0.000
H34.9 Retinal vascular occlusion, unspecified
0.654 0.346 0.000
H34.2 Other retinal artery occlusions
0.654 0.346 0.000
H34.1 Central retinal artery occlusion
0.654 0.346 0.000
H34.0 Transient retinal artery occlusion
0.654 0.346 0.000
H94 Other disorders of ear in diseases classified elsewhere
0.654 0.346 0.000
J20-J22 Other acute lower respiratory infections
0.654 0.346 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.653 0.347 0.000
M50.1 Cervical disk disorder with radiculopathy
0.652 0.348 0.000
I60 Subarachnoid haemorrhage
0.652 0.348 0.000
M54.57 Low back pain (Lumbosacral region)
0.652 0.348 0.000
F06 Other mental disorders due to brain damage and dysfunction and to physical disease
0.652 0.348 0.000
F25 Schizoaffective disorders
0.651 0.349 0.000
F23 Acute and transient psychotic disorders
0.651 0.349 0.000
F29 Unspecified nonorganic psychosis
0.651 0.349 0.000
F28 Other nonorganic psychotic disorders
0.651 0.349 0.000
F24 Induced delusional disorder
0.651 0.349 0.000
F21 Schizotypal disorder
0.651 0.349 0.000
H21 Other disorders of iris and ciliary body
0.651 0.349 0.000
F20.9 Schizophrenia, unspecified
0.650 0.350 0.000
I73.9 Peripheral vascular disease, unspecified
0.650 0.350 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.649 0.350 0.000
Q80-Q89 Other congenital malformations
0.649 0.350 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.649 0.350 0.000
Q35-Q37 Cleft lip and cleft palate
0.649 0.350 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.649 0.350 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.649 0.350 0.000
F99 Mental disorder, not otherwise specified
0.649 0.351 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.649 0.351 0.000
Y35-Y36 Legal intervention and operations of war
0.649 0.351 0.000
Y10-Y34 Event of undetermined intent
0.649 0.351 0.000
Y00-Y09 Assault
0.649 0.351 0.000
X85-X99 Assault
0.649 0.351 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.649 0.351 0.000
X50-X57 Overexertion, travel and privation
0.649 0.351 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.649 0.351 0.000
X30-X39 Exposure to forces of nature
0.649 0.351 0.000
X20-X29 Contact with venomous animals and plants
0.649 0.351 0.000
X10-X19 Contact with heat and hot substances
0.649 0.351 0.000
X00-X09 Exposure to smoke, fire and flames
0.649 0.351 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.649 0.351 0.000
W75-W84 Other accidental threats to breathing
0.649 0.351 0.000
W65-W74 Accidental drowning and submersion
0.649 0.351 0.000
W50-W64 Exposure to animate mechanical forces
0.649 0.351 0.000
V98-V99 Other and unspecified transport accidents
0.649 0.351 0.000
V95-V97 Air and space transport accidents
0.649 0.351 0.000
V90-V94 Water transport accidents
0.649 0.351 0.000
V70-V79 Bus occupant injured in transport accident
0.649 0.351 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.649 0.351 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.649 0.351 0.000
V40-V49 Car occupant injured in transport accident
0.649 0.351 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.649 0.351 0.000
V01-V09 Pedestrian injured in transport accident
0.649 0.351 0.000
S52 Fracture of forearm
0.649 0.351 0.000
G20-G26 Extrapyramidal and movement disorders
0.648 0.352 0.000
I77.5 Necrosis of artery
0.648 0.352 0.000
I77.4 Coeliac artery compression syndrome
0.648 0.352 0.000
I77.3 Arterial fibromuscular dysplasia
0.648 0.352 0.000
I77.2 Rupture of artery
0.648 0.352 0.000
I77.0 Arteriovenous fistula, acquired
0.648 0.352 0.000
I09 Other rheumatic heart diseases
0.647 0.353 0.000
I06 Rheumatic aortic valve diseases
0.647 0.353 0.000
I05 Rheumatic mitral valve diseases
0.647 0.353 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.646 0.354 0.000
S20 Superficial injury of thorax
0.646 0.354 0.000
F05 Delirium, not induced by alcohol and other psychoactive substances
0.645 0.355 0.000
I07 Rheumatic tricuspid valve diseases
0.644 0.356 0.000
S67.0 Crushing injury of thumb and other finger(s)
0.643 0.357 0.000
J33.1 Polypoid sinus degeneration
0.642 0.357 0.000
T66-T78 Other and unspecified effects of external causes
0.642 0.358 0.000
M54.50 Low back pain (Multiple sites in spine)
0.642 0.358 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.641 0.358 0.000
H60-H62 Diseases of external ear
0.641 0.359 0.000
Q38 Other congenital malformations of tongue, mouth and pharynx
0.641 0.359 0.000
H58 Other disorders of eye and adnexa in diseases classified elsewhere
0.639 0.361 0.000
D05 Carcinoma in situ of breast
0.639 0.361 0.000
I74.9 Embolism and thrombosis of unspecified artery
0.638 0.362 0.000
I74.8 Embolism and thrombosis of other arteries
0.638 0.362 0.000
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.638 0.362 0.000
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.638 0.362 0.000
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.638 0.362 0.000
I74.0 Embolism and thrombosis of abdominal aorta
0.638 0.362 0.000
H18 Other disorders of cornea
0.638 0.362 0.000
I49.8 Other specified cardiac arrhythmias
0.638 0.362 0.000
E40-E46 Malnutrition
0.638 0.362 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.637 0.362 0.000
F40 Phobic anxiety disorders
0.637 0.363 0.000
H25-H28 Disorders of lens
0.637 0.363 0.000
H43 Disorders of vitreous body
0.637 0.363 0.000
E10.4 With neurological complications
0.636 0.364 0.000
S92 Fracture of foot, except ankle
0.636 0.364 0.000
J60-J70 Lung diseases due to external agents
0.635 0.365 0.000
S60.9 Superficial injury of wrist and hand, unspecified
0.634 0.366 0.000
I22.1 Subsequent myocardial infarction of inferior wall
0.633 0.367 0.000
J35.0 Chronic tonsillitis
0.632 0.368 0.000
D80-D89 Certain disorders involving the immune mechanism
0.631 0.369 0.000
L71 Rosacea
0.630 0.369 0.000
S66.1 Injury of flexor muscle and tendon of other finger at wrist and hand level
0.630 0.370 0.000
F43 Reaction to severe stress, and adjustment disorders
0.630 0.370 0.000
L10-L14 Bullous disorders
0.630 0.370 0.000
M54.3 Sciatica
0.628 0.372 0.000
I69.3 Sequelae of cerebral infarction
0.628 0.372 0.000
D55-D59 Haemolytic anaemias
0.628 0.372 0.000
I45.9 Conduction disorder, unspecified
0.627 0.373 0.000
F81 Specific developmental disorders of scholastic skills
0.626 0.374 0.000
M50.3 Other cervical disk degeneration
0.626 0.374 0.000
M50.9 Cervical disk disorder, unspecified
0.624 0.376 0.000
M50.8 Other cervical disk disorders
0.624 0.376 0.000
M50.2 Other cervical disk displacement
0.624 0.376 0.000
I78 Diseases of capillaries
0.624 0.376 0.000
H80-H83 Diseases of inner ear
0.623 0.376 0.000
H20 Iridocyclitis
0.623 0.377 0.000
I49.5 Sick sinus syndrome
0.622 0.378 0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs
0.622 0.378 0.000
G96 Other disorders of central nervous system
0.621 0.379 0.000
J32.0 Chronic maxillary sinusitis
0.621 0.379 0.000
H40 Glaucoma
0.621 0.379 0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.620 0.380 0.000
T39.4 Antirheumatics, not elsewhere classified
0.620 0.380 0.000
T39.2 Pyrazolone derivatives
0.620 0.380 0.000
I45.6 Preexcitation syndrome
0.619 0.381 0.000
J80 Adult respiratory distress syndrome
0.619 0.381 0.000
J38 Diseases of vocal cords and larynx, not elsewhere classified
0.619 0.381 0.000
I63.2 Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
0.619 0.381 0.000
I24 Other acute ischaemic heart diseases
0.618 0.382 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.617 0.383 0.000
D68 Other coagulation defects
0.617 0.383 0.000
F20.0 Paranoid schizophrenia
0.617 0.383 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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