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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs11946166
log Bayes Factor = 19.0163
Chromosome 4   position 158,034,727  (GRCh37) Explore rs11946166 on Ensembl!
Variant rs11946166 is part of Cluster X0059

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
Chapter I Certain infectious and parasitic diseases
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.999 0.001 0.000
Chapter XX External causes of morbidity and mortality
0.998 0.002 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.998 0.002 0.000
Chapter VII Diseases of the eye and adnexa
0.997 0.003 0.000
Chapter VI Diseases of the nervous system
0.992 0.008 0.000
A30-A49 Other bacterial diseases
0.992 0.008 0.000
E10-E14 Diabetes mellitus
0.991 0.009 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.991 0.009 0.000
M50-M54 Other dorsopathies
0.989 0.011 0.000
M54 Dorsalgia
0.986 0.014 0.000
B95-B98 Bacterial, viral and other infectious agents
0.986 0.014 0.000
Chapter XIV Diseases of the genitourinary system
0.984 0.016 0.000
A41 Other septicaemia
0.984 0.016 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.982 0.018 0.000
A41.9 Septicaemia, unspecified
0.976 0.024 0.000
R50-R69 General symptoms and signs
0.975 0.025 0.000
E70-E90 Metabolic disorders
0.967 0.033 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.966 0.034 0.000
M70-M79 Other soft tissue disorders
0.965 0.035 0.000
G40-G47 Episodic and paroxysmal disorders
0.964 0.036 0.000
H30-H36 Disorders of choroid and retina
0.964 0.036 0.000
M54.5 Low back pain
0.964 0.036 0.000
B96 Other bacterial agents as the cause of diseases classified to other chapters
0.963 0.037 0.000
N30-N39 Other diseases of urinary system
0.955 0.045 0.000
E11 Non-insulin-dependent diabetes mellitus
0.951 0.049 0.000
N17-N19 Renal failure
0.951 0.049 0.000
N39 Other disorders of urinary system
0.951 0.049 0.000
Chapter IX Diseases of the circulatory system
0.950 0.050 0.000
E10 Insulin-dependent diabetes mellitus
0.949 0.051 0.000
R51 Headache
0.948 0.052 0.000
E86 Volume depletion
0.947 0.053 0.000
M54.59 Low back pain (Site unspecified)
0.947 0.053 0.000
Chapter II Neoplasms
0.945 0.055 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.943 0.057 0.000
H25-H28 Disorders of lens
0.940 0.060 0.000
M54.9 Dorsalgia, unspecified
0.937 0.063 0.000
R53 Malaise and fatigue
0.936 0.064 0.000
Chapter V Mental and behavioural disorders
0.932 0.068 0.000
N39.3 Stress incontinence
0.928 0.072 0.000
M05-M14 Inflammatory polyarthropathies
0.914 0.086 0.000
G40 Epilepsy
0.911 0.089 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.907 0.093 0.000
H25 Senile cataract
0.907 0.093 0.000
B96.2 Escherichia coli [E. coli] as the cause of diseases classified to other chapters
0.904 0.096 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.902 0.098 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.901 0.099 0.000
S40-S49 Injuries to the shoulder and upper arm
0.894 0.106 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.894 0.106 0.000
I30-I52 Other forms of heart disease
0.893 0.107 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.892 0.108 0.000
E65-E68 Obesity and other hyperalimentation
0.891 0.109 0.000
M15-M19 Arthrosis
0.890 0.110 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.888 0.112 0.000
R52 Pain, not elsewhere classified
0.887 0.113 0.000
M80-M85 Disorders of bone density and structure
0.885 0.115 0.000
N17 Acute renal failure
0.885 0.115 0.000
N00-N08 Glomerular diseases
0.885 0.115 0.000
R41 Other symptoms and signs involving cognitive functions and awareness
0.881 0.119 0.000
M75 Shoulder lesions
0.879 0.121 0.000
M54.99 Dorsalgia, unspecified (Site unspecified)
0.877 0.123 0.000
T93 Sequelae of injuries of lower limb
0.876 0.124 0.000
N18 Chronic renal failure
0.876 0.124 0.000
E10.9 Without complications
0.874 0.126 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
0.872 0.128 0.000
M17 Gonarthrosis [arthrosis of knee]
0.871 0.129 0.000
M17.9 Gonarthrosis, unspecified
0.869 0.131 0.000
I50 Heart failure
0.868 0.132 0.000
R59 Enlarged lymph nodes
0.868 0.132 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.862 0.138 0.000
H10-H13 Disorders of conjunctiva
0.860 0.140 0.000
H25.1 Senile nuclear cataract
0.859 0.141 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.859 0.141 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.858 0.142 0.000
N39.0 Urinary tract infection, site not specified
0.858 0.142 0.000
E11.9 Without complications
0.857 0.143 0.000
S10-S19 Injuries to the neck
0.855 0.145 0.000
G40.9 Epilepsy, unspecified
0.853 0.147 0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters
0.851 0.149 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.850 0.150 0.000
G90-G99 Other disorders of the nervous system
0.847 0.153 0.000
S80-S89 Injuries to the knee and lower leg
0.845 0.155 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.844 0.156 0.000
H25.8 Other senile cataract
0.844 0.156 0.000
V10-V19 Pedal cyclist injured in transport accident
0.844 0.156 0.000
H35 Other retinal disorders
0.843 0.157 0.000
S60-S69 Injuries to the wrist and hand
0.842 0.158 0.000
B96.1 Klebsiella pneumoniae [K. pneumoniae] as the cause of diseases classified to other chapters
0.842 0.158 0.000
Y51 Drugs primarily affecting the autonomic nervous system
0.842 0.158 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.841 0.159 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.841 0.159 0.000
R41.0 Disorientation, unspecified
0.839 0.161 0.000
N17.9 Acute renal failure, unspecified
0.838 0.162 0.000
Y40 Systemic antibiotics
0.837 0.163 0.000
R58 Haemorrhage, not elsewhere classified
0.834 0.166 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.832 0.168 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.831 0.169 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.830 0.170 0.000
R40 Somnolence, stupor and coma
0.827 0.173 0.000
M10 Gout
0.825 0.175 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.823 0.177 0.000
M54.1 Radiculopathy
0.823 0.177 0.000
M86-M90 Other osteopathies
0.823 0.177 0.000
N25-N29 Other disorders of kidney and ureter
0.823 0.177 0.000
I05-I09 Chronic rheumatic heart diseases
0.823 0.177 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.820 0.180 0.000
Y43 Primarily systemic agents
0.820 0.180 0.000
C79 Secondary malignant neoplasm of other sites
0.819 0.181 0.000
M65-M68 Disorders of synovium and tendon
0.818 0.182 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.817 0.183 0.000
Y52 Agents primarily affecting the cardiovascular system
0.816 0.184 0.000
I60-I69 Cerebrovascular diseases
0.816 0.184 0.000
D70 Agranulocytosis
0.815 0.185 0.000
L97 Ulcer of lower limb, not elsewhere classified
0.815 0.185 0.000
E66 Obesity
0.813 0.187 0.000
C79.5 Secondary malignant neoplasm of bone and bone marrow
0.813 0.187 0.000
T98 Sequelae of other and unspecified effects of external causes
0.813 0.187 0.000
B35-B49 Mycoses
0.810 0.189 0.000
W20-W49 Exposure to inanimate mechanical forces
0.810 0.190 0.000
Y95 Nosocomial condition
0.809 0.191 0.000
H36 Retinal disorders in diseases classified elsewhere
0.806 0.194 0.000
M91-M94 Chondropathies
0.805 0.195 0.000
E20-E35 Disorders of other endocrine glands
0.803 0.197 0.000
A46 Erysipelas
0.803 0.197 0.000
B15-B19 Viral hepatitis
0.803 0.197 0.000
I50.1 Left ventricular failure
0.801 0.199 0.000
G40.1 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
0.801 0.199 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.798 0.202 0.000
H52 Disorders of refraction and accommodation
0.798 0.202 0.000
E10.3 With ophthalmic complications
0.796 0.204 0.000
B25-B34 Other viral diseases
0.795 0.205 0.000
M81 Osteoporosis without pathological fracture
0.795 0.205 0.000
H43-H45 Disorders of vitreous body and globe
0.795 0.205 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.793 0.207 0.000
M54.56 Low back pain (Lumbar region)
0.793 0.207 0.000
E11.2 With renal complications
0.791 0.209 0.000
G44 Other headache syndromes
0.790 0.210 0.000
M54.3 Sciatica
0.789 0.211 0.000
R59.0 Localised enlarged lymph nodes
0.788 0.212 0.000
Chapter XXII Codes for special purposes
0.787 0.213 0.000
E66.8 Other obesity
0.785 0.215 0.000
T90 Sequelae of injuries of head
0.784 0.216 0.000
L91 Hypertrophic disorders of skin
0.782 0.218 0.000
T92 Sequelae of injuries of upper limb
0.782 0.218 0.000
M79.8 Other specified soft tissue disorders
0.782 0.218 0.000
E11.3 With ophthalmic complications
0.780 0.220 0.000
N39.4 Other specified urinary incontinence
0.780 0.220 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.779 0.221 0.000
G30-G32 Other degenerative diseases of the nervous system
0.778 0.222 0.000
D10-D36 Benign neoplasms
0.778 0.222 0.000
D00-D09 In situ neoplasms
0.778 0.222 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.777 0.222 0.000
H31 Other disorders of choroid
0.777 0.223 0.000
L89 Decubitus ulcer
0.777 0.223 0.000
H34 Retinal vascular occlusions
0.776 0.224 0.000
V20-V29 Motorcycle rider injured in transport accident
0.774 0.226 0.000
B96.8 Other specified bacterial agents as the cause of diseases classified to other chapters
0.774 0.226 0.000
L83 Acanthosis nigricans
0.772 0.228 0.000
N02 Recurrent and persistent haematuria
0.770 0.230 0.000
H33 Retinal detachments and breaks
0.768 0.232 0.000
A41.5 Septicaemia due to other Gram-negative organisms
0.768 0.232 0.000
N70-N77 Inflammatory diseases of female pelvic organs
0.766 0.234 0.000
T82.5 Mechanical complication of other cardiac and vascular devices and implants
0.766 0.234 0.000
S42 Fracture of shoulder and upper arm
0.765 0.235 0.000
D17 Benign lipomatous neoplasm
0.764 0.236 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.763 0.237 0.000
R57 Shock, not elsewhere classified
0.763 0.237 0.000
H11 Other disorders of conjunctiva
0.763 0.237 0.000
M10.9 Gout, unspecified
0.761 0.238 0.000
N08 Glomerular disorders in diseases classified elsewhere
0.761 0.239 0.000
R68 Other general symptoms and signs
0.760 0.240 0.000
E10.2 With renal complications
0.760 0.240 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.759 0.241 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.758 0.241 0.000
E13 Other specified diabetes mellitus
0.757 0.243 0.000
R61 Hyperhidrosis
0.757 0.243 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.757 0.243 0.000
M79.0 Rheumatism, unspecified
0.757 0.243 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.756 0.244 0.000
S20-S29 Injuries to the thorax
0.756 0.244 0.000
R52.1 Chronic intractable pain
0.756 0.244 0.000
N20-N23 Urolithiasis
0.755 0.245 0.000
I50.0 Congestive heart failure
0.752 0.248 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.752 0.248 0.000
W00-W19 Falls
0.751 0.249 0.000
I38 Endocarditis, valve unspecified
0.750 0.250 0.000
M75.0 Adhesive capsulitis of shoulder
0.749 0.251 0.000
N18.3 Chronic kidney disease, stage 3
0.749 0.251 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.749 0.251 0.000
E50-E64 Other nutritional deficiencies
0.748 0.252 0.000
I10-I15 Hypertensive diseases
0.748 0.252 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.747 0.252 0.000
B98 Other specified infectious agents as the cause of diseases classified to other chapters
0.747 0.253 0.000
E40-E46 Malnutrition
0.745 0.255 0.000
M54.94 Dorsalgia, unspecified (Thoracic region)
0.745 0.255 0.000
R52.0 Acute pain
0.745 0.255 0.000
I63 Cerebral infarction
0.744 0.256 0.000
M45-M49 Spondylopathies
0.743 0.257 0.000
H55-H59 Other disorders of eye and adnexa
0.742 0.258 0.000
I60 Subarachnoid haemorrhage
0.742 0.258 0.000
D75 Other diseases of blood and blood-forming organs
0.741 0.259 0.000
F00 Dementia in Alzheimer's disease
0.741 0.259 0.000
B96.4 Proteus (mirabilis)(morganii) as the cause of diseases classified to other chapters
0.739 0.261 0.000
H35.3 Degeneration of macula and posterior pole
0.739 0.261 0.000
G41 Status epilepticus
0.738 0.262 0.000
N39.8 Other specified disorders of urinary system
0.737 0.263 0.000
R79 Other abnormal findings of blood chemistry
0.737 0.263 0.000
Y51.7 Beta-Adrenoreceptor antagonists, not elsewhere classified
0.736 0.264 0.000
G81 Hemiplegia
0.734 0.266 0.000
R40.2 Coma, unspecified
0.734 0.266 0.000
G45 Transient cerebral ischaemic attacks and related syndromes
0.733 0.267 0.000
V18 Pedal cyclist injured in noncollision transport accident
0.733 0.267 0.000
S90-S99 Injuries to the ankle and foot
0.732 0.268 0.000
T93.3 Sequelae of dislocation, sprain and strain of lower limb
0.732 0.268 0.000
I50.9 Heart failure, unspecified
0.731 0.269 0.000
N18.0 End-stage renal disease
0.731 0.269 0.000
M54.58 Low back pain (Sacral and sacrococcygeal region)
0.731 0.269 0.000
E11.5 With peripheral circulatory complications
0.730 0.270 0.000
N18.4 Chronic kidney disease, stage 4
0.729 0.271 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.729 0.271 0.000
M75.3 Calcific tendinitis of shoulder
0.726 0.274 0.000
R47-R49 Symptoms and signs involving speech and voice
0.726 0.274 0.000
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts
0.725 0.275 0.000
M54.96 Dorsalgia, unspecified (Lumbar region)
0.725 0.275 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.724 0.275 0.000
T93.2 Sequelae of other fractures of lower limb
0.724 0.275 0.000
S50-S59 Injuries to the elbow and forearm
0.721 0.279 0.000
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level
0.721 0.279 0.000
A80-A89 Viral infections of the central nervous system
0.721 0.279 0.000
G93 Other disorders of brain
0.720 0.280 0.000
Y42.5 Other oestrogens and progestogens
0.719 0.281 0.000
A49 Bacterial infection of unspecified site
0.718 0.282 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.717 0.283 0.000
M60-M63 Disorders of muscles
0.717 0.283 0.000
M00-M03 Infectious arthropathies
0.717 0.283 0.000
B99-B99 Other infectious diseases
0.717 0.283 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.717 0.283 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.717 0.283 0.000
B65-B83 Helminthiases
0.717 0.283 0.000
B50-B64 Protozoal diseases
0.717 0.283 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.717 0.283 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.717 0.283 0.000
A75-A79 Rickettsioses
0.717 0.283 0.000
A70-A74 Other diseases caused by chlamydiae
0.717 0.283 0.000
A65-A69 Other spirochaetal diseases
0.717 0.283 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.717 0.283 0.000
A20-A28 Certain zoonotic bacterial diseases
0.717 0.283 0.000
A15-A19 Tuberculosis
0.717 0.283 0.000
H40-H42 Glaucoma
0.716 0.284 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.716 0.284 0.000
Y35-Y36 Legal intervention and operations of war
0.716 0.284 0.000
Y10-Y34 Event of undetermined intent
0.716 0.284 0.000
Y00-Y09 Assault
0.716 0.284 0.000
X85-X99 Assault
0.716 0.284 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.716 0.284 0.000
X50-X57 Overexertion, travel and privation
0.716 0.284 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.716 0.284 0.000
X30-X39 Exposure to forces of nature
0.716 0.284 0.000
X20-X29 Contact with venomous animals and plants
0.716 0.284 0.000
X10-X19 Contact with heat and hot substances
0.716 0.284 0.000
X00-X09 Exposure to smoke, fire and flames
0.716 0.284 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.716 0.284 0.000
W75-W84 Other accidental threats to breathing
0.716 0.284 0.000
W65-W74 Accidental drowning and submersion
0.716 0.284 0.000
W50-W64 Exposure to animate mechanical forces
0.716 0.284 0.000
V98-V99 Other and unspecified transport accidents
0.716 0.284 0.000
V95-V97 Air and space transport accidents
0.716 0.284 0.000
V90-V94 Water transport accidents
0.716 0.284 0.000
V80-V89 Other land transport accidents
0.716 0.284 0.000
V70-V79 Bus occupant injured in transport accident
0.716 0.284 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.716 0.284 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.716 0.284 0.000
V40-V49 Car occupant injured in transport accident
0.716 0.284 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.716 0.284 0.000
V01-V09 Pedestrian injured in transport accident
0.716 0.284 0.000
T79-T79 Certain early complications of trauma
0.716 0.284 0.000
T33-T35 Frostbite
0.716 0.284 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.716 0.284 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.716 0.284 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.716 0.284 0.000
T00-T07 Injuries involving multiple body regions
0.716 0.284 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.715 0.285 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.715 0.285 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.715 0.285 0.000
G47 Sleep disorders
0.715 0.285 0.000
M10.99 Gout, unspecified (Site unspecified)
0.714 0.286 0.000
E88 Other metabolic disorders
0.714 0.286 0.000
B96.3 Haemophilus influenzae [H. influenzae] as the cause of diseases classified to other chapters
0.713 0.287 0.000
G43 Migraine
0.713 0.287 0.000
A41.8 Other specified septicaemia
0.713 0.287 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.712 0.288 0.000
G70-G73 Diseases of myoneural junction and muscle
0.711 0.288 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.711 0.288 0.000
A48 Other bacterial diseases, not elsewhere classified
0.711 0.289 0.000
A44 Bartonellosis
0.711 0.289 0.000
A43 Nocardiosis
0.711 0.289 0.000
A42 Actinomycosis
0.711 0.289 0.000
A40 Streptococcal septicaemia
0.711 0.289 0.000
A39 Meningococcal infection
0.711 0.289 0.000
A37 Whooping cough
0.711 0.289 0.000
A36 Diphtheria
0.711 0.289 0.000
A32 Listeriosis
0.711 0.289 0.000
A31 Infection due to other mycobacteria
0.711 0.289 0.000
A30 Leprosy [Hansen's disease]
0.711 0.289 0.000
A38 Scarlet fever
0.711 0.289 0.000
A35 Other tetanus
0.711 0.289 0.000
A34 Obstetrical tetanus
0.711 0.289 0.000
A33 Tetanus neonatorum
0.711 0.289 0.000
E12 Malnutrition-related diabetes mellitus
0.710 0.289 0.000
M53 Other dorsopathies, not elsewhere classified
0.710 0.289 0.000
Y59 Other and unspecified vaccines and biological substances
0.710 0.290 0.000
Y58 Bacterial vaccines
0.710 0.290 0.000
Y57 Other and unspecified drugs and medicaments
0.710 0.290 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.710 0.290 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.710 0.290 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.710 0.290 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.710 0.290 0.000
Y48 Anaesthetics and therapeutic gases
0.710 0.290 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.710 0.290 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.710 0.290 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.710 0.290 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.710 0.290 0.000
L89.1 Stage II decubitus ulcer
0.709 0.291 0.000
M75.1 Rotator cuff syndrome
0.709 0.291 0.000
G57 Mononeuropathies of lower limb
0.709 0.291 0.000
L20-L30 Dermatitis and eczema
0.708 0.291 0.000
M54.8 Other dorsalgia
0.707 0.293 0.000
M54.6 Pain in thoracic spine
0.707 0.293 0.000
M54.0 Panniculitis affecting regions of neck and back
0.707 0.293 0.000
M54.12 Radiculopathy (Cervical region)
0.706 0.294 0.000
R50 Fever of unknown origin
0.706 0.294 0.000
S30 Superficial injury of abdomen, lower back and pelvis
0.706 0.294 0.000
T66-T78 Other and unspecified effects of external causes
0.706 0.294 0.000
C43-C44 Melanoma and other malignant neoplasms of skin
0.706 0.294 0.000
A41.4 Septicaemia due to anaerobes
0.705 0.294 0.000
A41.3 Septicaemia due to Haemophilus influenzae
0.705 0.294 0.000
A41.2 Septicaemia due to unspecified staphylococcus
0.705 0.294 0.000
A41.1 Septicaemia due to other specified staphylococcus
0.705 0.294 0.000
I42 Cardiomyopathy
0.705 0.295 0.000
M79.6 Pain in limb
0.705 0.295 0.000
Y42.7 Androgens and anabolic congeners
0.704 0.296 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.704 0.296 0.000
E10.4 With neurological complications
0.704 0.296 0.000
A00-A09 Intestinal infectious diseases
0.703 0.297 0.000
T98.3 Sequelae of complications of surgical and medical care, not elsewhere classified
0.703 0.297 0.000
N39.9 Disorder of urinary system, unspecified
0.703 0.297 0.000
L91.8 Other hypertrophic disorders of skin
0.702 0.298 0.000
I63.9 Cerebral infarction, unspecified
0.701 0.299 0.000
I12 Hypertensive renal disease
0.701 0.299 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.701 0.299 0.000
R93 Abnormal findings on diagnostic imaging of other body structures
0.700 0.300 0.000
H52.1 Myopia
0.700 0.300 0.000
R65 Systemic Inflammatory Response Syndrome [SIRS]
0.699 0.301 0.000
R62 Lack of expected normal physiological development
0.699 0.301 0.000
R64 Cachexia
0.699 0.301 0.000
F41 Other anxiety disorders
0.698 0.302 0.000
S46 Injury of muscle and tendon at shoulder and upper arm level
0.698 0.302 0.000
I08 Multiple valve diseases
0.698 0.302 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.698 0.302 0.000
F03 Unspecified dementia
0.698 0.302 0.000
Y56.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified
0.698 0.302 0.000
I33 Acute and subacute endocarditis
0.698 0.302 0.000
G95 Other diseases of spinal cord
0.697 0.303 0.000
M71 Other bursopathies
0.697 0.303 0.000
B95.3 Streptococcus pneumoniae as the cause of diseases classified to other chapters
0.696 0.303 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.696 0.304 0.000
F43 Reaction to severe stress, and adjustment disorders
0.696 0.304 0.000
B95.6 Staphylococcus aureus as the cause of diseases classified to other chapters
0.696 0.304 0.000
A41.0 Septicaemia due to Staphylococcus aureus
0.696 0.304 0.000
T93.8 Sequelae of other specified injuries of lower limb
0.695 0.305 0.000
M13 Other arthritis
0.695 0.305 0.000
E85 Amyloidosis
0.694 0.306 0.000
E84 Cystic fibrosis
0.694 0.306 0.000
E79 Disorders of purine and pyrimidine metabolism
0.694 0.306 0.000
E77 Disorders of glycoprotein metabolism
0.694 0.306 0.000
E76 Disorders of glycosaminoglycan metabolism
0.694 0.306 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.694 0.306 0.000
E74 Other disorders of carbohydrate metabolism
0.694 0.306 0.000
E73 Lactose intolerance
0.694 0.306 0.000
E72 Other disorders of amino-acid metabolism
0.694 0.306 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.694 0.306 0.000
E70 Disorders of aromatic amino-acid metabolism
0.694 0.306 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.694 0.306 0.000
R59.1 Generalised enlarged lymph nodes
0.694 0.306 0.000
C15-C26 Malignant neoplasms of digestive organs
0.694 0.306 0.000
T95 Sequelae of burns, corrosions and frostbite
0.693 0.307 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.693 0.307 0.000
T91 Sequelae of injuries of neck and trunk
0.693 0.307 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.693 0.307 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.693 0.307 0.000
S62 Fracture at wrist and hand level
0.692 0.308 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.692 0.308 0.000
H36.0 Diabetic retinopathy
0.692 0.308 0.000
R52.2 Other chronic pain
0.692 0.308 0.000
M76 Enthesopathies of lower limb, excluding foot
0.692 0.308 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.692 0.308 0.000
M81.9 Osteoporosis, unspecified
0.692 0.308 0.000
G46 Vascular syndromes of brain in cerebrovascular diseases
0.691 0.309 0.000
M40-M43 Deforming dorsopathies
0.691 0.309 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.691 0.309 0.000
H30 Chorioretinal inflammation
0.691 0.309 0.000
M54.55 Low back pain (Thoracolumbar region)
0.691 0.309 0.000
M54.54 Low back pain-Thoracic
0.691 0.309 0.000
M54.53 Low back pain-Cervicothoracic
0.691 0.309 0.000
M54.52 Low back pain-Cervical
0.691 0.309 0.000
M54.51 Low back pain-Occipit-atl-axl
0.691 0.309 0.000
M54.50 Low back pain (Multiple sites in spine)
0.691 0.309 0.000
E11.4 With neurological complications
0.690 0.309 0.000
B96.7 Clostridium perfringens [C. perfringens] as the cause of diseases classified to other chapters
0.690 0.310 0.000
B96.6 Bacillus fragilis [B. fragilis] as the cause of diseases classified to other chapters
0.690 0.310 0.000
B96.0 Mycoplasma pneumoniae [M. pneumoniae] as the cause of diseases classified to other chapters
0.690 0.310 0.000
H50 Other strabismus
0.689 0.311 0.000
N02.9 Unspecified
0.688 0.312 0.000
D17.1 Benign lipomatous neoplasm of skin and subcutaneous tissue of trunk
0.688 0.312 0.000
D17.2 Benign lipomatous neoplasm of skin and subcutaneous tissue of limbs
0.688 0.312 0.000
S81 Open wound of lower leg
0.687 0.312 0.000
B97 Viral agents as the cause of diseases classified to other chapters
0.687 0.313 0.000
Y44 Agents primarily affecting blood constituents
0.687 0.313 0.000
S14 Injury of nerves and spinal cord at neck level
0.687 0.313 0.000
C30 Malignant neoplasm of nasal cavity and middle ear
0.686 0.314 0.000
E87.7 Fluid overload
0.686 0.314 0.000
G20-G26 Extrapyramidal and movement disorders
0.686 0.314 0.000
G56 Mononeuropathies of upper limb
0.685 0.315 0.000
E83 Disorders of mineral metabolism
0.685 0.315 0.000
S13 Dislocation, sprain and strain of joints and ligaments at neck level
0.685 0.315 0.000
N37 Urethral disorders in diseases classified elsewhere
0.685 0.315 0.000
N34 Urethritis and urethral syndrome
0.685 0.315 0.000
N33 Bladder disorders in diseases classified elsewhere
0.685 0.315 0.000
D23 Other benign neoplasms of skin
0.685 0.315 0.000
M79.86 Other specified soft tissue disorders (Lower leg)
0.684 0.316 0.000
N28 Other disorders of kidney and ureter, not elsewhere classified
0.683 0.316 0.000
M86 Osteomyelitis
0.683 0.317 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.682 0.318 0.000
M51 Other intervertebral disk disorders
0.682 0.318 0.000
E11.8 With unspecified complications
0.682 0.318 0.000
E11.7 With multiple complications
0.682 0.318 0.000
E11.6 With other specified complications
0.682 0.318 0.000
E11.1 With ketoacidosis
0.682 0.318 0.000
E11.0 With coma
0.682 0.318 0.000
Y40.8 Other systemic antibiotics
0.682 0.318 0.000
N39.2 Orthostatic proteinuria, unspecified
0.681 0.318 0.000
N39.1 Persistent proteinuria, unspecified
0.681 0.318 0.000
Y52.1 Calcium-channel blockers
0.681 0.319 0.000
M11 Other crystal arthropathies
0.681 0.319 0.000
M79.7 Fibromyalgia
0.681 0.319 0.000
I00-I02 Acute rheumatic fever
0.681 0.319 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.681 0.319 0.000
N20 Calculus of kidney and ureter
0.680 0.320 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.680 0.320 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.680 0.320 0.000
E10.8 With unspecified complications
0.680 0.320 0.000
E10.7 With multiple complications
0.680 0.320 0.000
E10.6 With other specified complications
0.680 0.320 0.000
E10.5 With peripheral circulatory complications
0.680 0.320 0.000
E10.0 With coma
0.680 0.320 0.000
M75.9 Shoulder lesion, unspecified
0.680 0.320 0.000
M05 Seropositive rheumatoid arthritis
0.680 0.320 0.000
W20 Struck by thrown, projected or falling object
0.680 0.320 0.000
B95.8 Unspecified staphylococcus as the cause of diseases classified to other chapters
0.678 0.322 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.677 0.322 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.677 0.322 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.677 0.322 0.000
D17.0 Benign lipomatous neoplasm of skin and subcutaneous tissue of head, face and neck
0.677 0.323 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.677 0.323 0.000
S49 Other and unspecified injuries of shoulder and upper arm
0.677 0.323 0.000
C34 Malignant neoplasm of bronchus and lung
0.676 0.324 0.000
R46 Symptoms and signs involving appearance and behaviour
0.676 0.324 0.000
R43 Disturbances of smell and taste
0.676 0.324 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.676 0.324 0.000
X60-X84 Intentional self-harm
0.675 0.325 0.000
C79.6 Secondary malignant neoplasm of ovary
0.675 0.325 0.000
M54.4 Lumbago with sciatica
0.675 0.325 0.000
S80 Superficial injury of lower leg
0.675 0.325 0.000
I44 Atrioventricular and left bundle-branch block
0.674 0.326 0.000
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle
0.674 0.326 0.000
H28 Cataract and other disorders of lens in diseases classified elsewhere
0.674 0.326 0.000
H27 Other disorders of lens
0.674 0.326 0.000
I12.0 Hypertensive renal disease with renal failure
0.673 0.327 0.000
N08.3 Glomerular disorders in diabetes mellitus
0.672 0.328 0.000
M54.98 Dorsalgia, unspecified (Sacral and sacrococcygeal region)
0.672 0.328 0.000
M54.97 Dorsalgia, unspecified (Lumbosacral region)
0.672 0.328 0.000
M54.95 Dorsalgia, unspecified (Thoracolumbar region)
0.672 0.328 0.000
M54.93 Dorsalgia, unspecified (Cervicothoracic region)
0.672 0.328 0.000
M54.92 Dorsalgia, unspecified (Cervical region)
0.672 0.328 0.000
M54.91 Dorsalgia, unspecified (Occipito-atlanto-axial region)
0.672 0.328 0.000
M54.90 Dorsalgia, unspecified (Multiple sites in spine)
0.672 0.328 0.000
T82.3 Mechanical complication of other vascular grafts
0.671 0.329 0.000
D50-D53 Nutritional anaemias
0.670 0.330 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.670 0.330 0.000
N18.2 Chronic kidney disease, stage 2
0.670 0.330 0.000
H35.5 Hereditary retinal dystrophy
0.669 0.331 0.000
T86 Failure and rejection of transplanted organs and tissues
0.669 0.331 0.000
H11.4 Other conjunctival vascular disorders and cysts
0.668 0.332 0.000
R41.8 Other and unspecified symptoms and signs involving cognitive functions and awareness
0.668 0.332 0.000
F99-F99 Unspecified mental disorder
0.668 0.332 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.668 0.332 0.000
F70-F79 Mental retardation
0.668 0.332 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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