TreeWAS – Variant ID: rs12248541

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability
# Top node	0.072	0.928
Chapter IX Diseases of the circulatory system	0.071	0.929
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	0.067	0.933
I20-I25 Ischaemic heart diseases	0.066	0.934
Chapter XI Diseases of the digestive system	0.060	0.940
I30-I52 Other forms of heart disease	0.060	0.940
I25 Chronic ischaemic heart disease	0.060	0.940
Chapter IV Endocrine, nutritional and metabolic diseases	0.058	0.942
Chapter XIV Diseases of the genitourinary system	0.058	0.942
R30-R39 Symptoms and signs involving the urinary system	0.057	0.943
Chapter XII Diseases of the skin and subcutaneous tissue	0.056	0.944
I20 Angina pectoris	0.055	0.945
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.054	0.946
I95-I99 Other and unspecified disorders of the circulatory system	0.054	0.946
Chapter XX External causes of morbidity and mortality	0.053	0.946
I70-I79 Diseases of arteries, arterioles and capillaries	0.053	0.946
I10-I15 Hypertensive diseases	0.053	0.947
Chapter XV Pregnancy, childbirth and the puerperium	0.053	0.947
I25.1 Atherosclerotic heart disease	0.053	0.947
Chapter II Neoplasms	0.053	0.947
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.053	0.947
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.052	0.947
R10-R19 Symptoms and signs involving the digestive system and abdomen	0.052	0.947
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour	0.052	0.948
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified	0.051	0.948
Chapter XXII Codes for special purposes	0.051	0.948
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.051	0.948
Chapter XVI Certain conditions originating in the perinatal period	0.051	0.948
Chapter VIII Diseases of the ear and mastoid process	0.051	0.948
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.051	0.949
Chapter I Certain infectious and parasitic diseases	0.051	0.949
R70-R79 Abnormal findings on examination of blood, without diagnosis	0.051	0.949
K90-K93 Other diseases of the digestive system	0.051	0.949
R00-R09 Symptoms and signs involving the circulatory and respiratory systems	0.051	0.949
I60-I69 Cerebrovascular diseases	0.051	0.949
I05-I09 Chronic rheumatic heart diseases	0.051	0.949
I00-I02 Acute rheumatic fever	0.051	0.949
Chapter VII Diseases of the eye and adnexa	0.051	0.949
Chapter XXI Factors influencing health status and contact with health services	0.051	0.949
Chapter X Diseases of the respiratory system	0.050	0.950
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis	0.050	0.950
I21 Acute myocardial infarction	0.050	0.950
I47 Paroxysmal tachycardia	0.049	0.951
N30-N39 Other diseases of urinary system	0.049	0.951
I50 Heart failure	0.048	0.952
K20-K31 Diseases of oesophagus, stomach and duodenum	0.048	0.952
R95-R99 Ill-defined and unknown causes of mortality	0.048	0.952
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis	0.048	0.952
R80-R82 Abnormal findings on examination of urine, without diagnosis	0.048	0.952
R47-R49 Symptoms and signs involving speech and voice	0.048	0.952
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems	0.048	0.952
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue	0.048	0.952
Chapter VI Diseases of the nervous system	0.048	0.952
R31 Unspecified haematuria	0.048	0.952
I24 Other acute ischaemic heart diseases	0.048	0.952
I23 Certain current complications following acute myocardial infarction	0.048	0.952
I22 Subsequent myocardial infarction	0.048	0.952
K50-K52 Noninfective enteritis and colitis	0.047	0.953
E00-E07 Disorders of thyroid gland	0.046	0.953
R50-R69 General symptoms and signs	0.046	0.953
Chapter V Mental and behavioural disorders	0.046	0.953
I25.8 Other forms of chronic ischaemic heart disease	0.046	0.953
L80-L99 Other disorders of the skin and subcutaneous tissue	0.046	0.954
N17-N19 Renal failure	0.046	0.954
I25.2 Old myocardial infarction	0.046	0.954
Z70-Z76 Persons encountering health services in other circumstances	0.046	0.954
R11 Nausea and vomiting	0.045	0.955
K92 Other diseases of digestive system	0.045	0.955
K40-K46 Hernia	0.045	0.955
I20.0 Unstable angina	0.045	0.955
R33 Retention of urine	0.044	0.956
I20.9 Angina pectoris, unspecified	0.043	0.956
K70-K77 Diseases of liver	0.043	0.957
K65-K67 Diseases of peritoneum	0.043	0.957
K35-K38 Diseases of appendix	0.043	0.957
K00-K14 Diseases of oral cavity, salivary glands and jaws	0.043	0.957
E65-E68 Obesity and other hyperalimentation	0.043	0.957
I52 Other heart disorders in diseases classified elsewhere	0.043	0.957
I51 Complications and ill-defined descriptions of heart disease	0.043	0.957
I49 Other cardiac arrhythmias	0.043	0.957
I48 Atrial fibrillation and flutter	0.043	0.957
I46 Cardiac arrest	0.043	0.957
I45 Other conduction disorders	0.043	0.957
I44 Atrioventricular and left bundle-branch block	0.043	0.957
I43 Cardiomyopathy in diseases classified elsewhere	0.043	0.957
I42 Cardiomyopathy	0.043	0.957
I41 Myocarditis in diseases classified elsewhere	0.043	0.957
I40 Acute myocarditis	0.043	0.957
I39 Endocarditis and heart valve disorders in diseases classified elsewhere	0.043	0.957
I37 Pulmonary valve disorders	0.043	0.957
I36 Nonrheumatic tricuspid valve disorders	0.043	0.957
I35 Nonrheumatic aortic valve disorders	0.043	0.957
I34 Nonrheumatic mitral valve disorders	0.043	0.957
I33 Acute and subacute endocarditis	0.043	0.957
I32 Pericarditis in diseases classified elsewhere	0.043	0.957
I31 Other diseases of pericardium	0.043	0.957
I30 Acute pericarditis	0.043	0.957
I38 Endocarditis, valve unspecified	0.043	0.957
I25.6 Silent myocardial ischaemia	0.043	0.957
I25.5 Ischaemic cardiomyopathy	0.043	0.957
I25.4 Coronary artery aneurysm	0.043	0.957
I25.3 Aneurysm of heart	0.043	0.957
I25.0 Atherosclerotic cardiovascular disease, so described	0.043	0.957
E10-E14 Diabetes mellitus	0.043	0.957
R39 Other symptoms and signs involving the urinary system	0.043	0.957
I25.9 Chronic ischaemic heart disease, unspecified	0.043	0.957
E70-E90 Metabolic disorders	0.043	0.957
Z72 Problems related to lifestyle	0.042	0.958
I95 Hypotension	0.042	0.958
R42 Dizziness and giddiness	0.042	0.958
E50-E64 Other nutritional deficiencies	0.042	0.958
E40-E46 Malnutrition	0.042	0.958
E20-E35 Disorders of other endocrine glands	0.042	0.958
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.042	0.958
M70-M79 Other soft tissue disorders	0.042	0.958
N99-N99 Other disorders of the genitourinary system	0.042	0.958
N70-N77 Inflammatory diseases of female pelvic organs	0.042	0.958
N60-N64 Disorders of breast	0.042	0.958
N25-N29 Other disorders of kidney and ureter	0.042	0.958
N20-N23 Urolithiasis	0.042	0.958
N10-N16 Renal tubulo-interstitial diseases	0.042	0.958
N00-N08 Glomerular diseases	0.042	0.958
R30 Pain associated with micturition	0.041	0.959
R36 Urethral discharge	0.041	0.959
R35 Polyuria	0.041	0.959
R34 Anuria and oliguria	0.041	0.959
R32 Unspecified urinary incontinence	0.041	0.959
I73 Other peripheral vascular diseases	0.041	0.959
I47.1 Supraventricular tachycardia	0.041	0.959
C43-C44 Melanoma and other malignant neoplasms of skin	0.041	0.959
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure	0.041	0.959
M45-M49 Spondylopathies	0.040	0.959
I10 Essential (primary) hypertension	0.040	0.959
M80-M85 Disorders of bone density and structure	0.040	0.959
L60-L75 Disorders of skin appendages	0.040	0.960
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue	0.040	0.960
L50-L54 Urticaria and erythema	0.040	0.960
L40-L45 Papulosquamous disorders	0.040	0.960
L20-L30 Dermatitis and eczema	0.040	0.960
L10-L14 Bullous disorders	0.040	0.960
K29 Gastritis and duodenitis	0.040	0.960
R79 Other abnormal findings of blood chemistry	0.040	0.960
I50.1 Left ventricular failure	0.040	0.960
O60-O75 Complications of labour and delivery	0.040	0.960
K80-K87 Disorders of gallbladder, biliary tract and pancreas	0.040	0.960
N32 Other disorders of bladder	0.040	0.960
I20.8 Other forms of angina pectoris	0.040	0.960
I20.1 Angina pectoris with documented spasm	0.040	0.960
C60-C63 Malignant neoplasms of male genital organs	0.039	0.960
I26 Pulmonary embolism	0.039	0.960
K30 Dyspepsia	0.039	0.961
N35 Urethral stricture	0.039	0.961
R07 Pain in throat and chest	0.039	0.961
R00 Abnormalities of heart beat	0.039	0.961
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.039	0.961
M91-M94 Chondropathies	0.039	0.961
M86-M90 Other osteopathies	0.039	0.961
M65-M68 Disorders of synovium and tendon	0.039	0.961
M60-M63 Disorders of muscles	0.039	0.961
M50-M54 Other dorsopathies	0.039	0.961
M40-M43 Deforming dorsopathies	0.039	0.961
M05-M14 Inflammatory polyarthropathies	0.039	0.961
M00-M03 Infectious arthropathies	0.039	0.961
I98 Other disorders of circulatory system in diseases classified elsewhere	0.039	0.961
I97 Postprocedural disorders of circulatory system, not elsewhere classified	0.039	0.961
I99 Other and unspecified disorders of circulatory system	0.039	0.961
D50-D53 Nutritional anaemias	0.039	0.961
S50-S59 Injuries to the elbow and forearm	0.039	0.961
I80 Phlebitis and thrombophlebitis	0.039	0.961
N40-N51 Diseases of male genital organs	0.039	0.961
N80-N98 Noninflammatory disorders of female genital tract	0.039	0.961
R19 Other symptoms and signs involving the digestive system and abdomen	0.039	0.961
L00-L08 Infections of the skin and subcutaneous tissue	0.038	0.961
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere	0.038	0.961
Y85-Y89 Sequelae of external causes of morbidity and mortality	0.038	0.961
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use	0.038	0.961
Y60-Y69 Misadventures to patients during surgical and medical care	0.038	0.961
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.038	0.961
Y35-Y36 Legal intervention and operations of war	0.038	0.961
Y10-Y34 Event of undetermined intent	0.038	0.961
Y00-Y09 Assault	0.038	0.961
X85-X99 Assault	0.038	0.961
X60-X84 Intentional self-harm	0.038	0.961
X58-X59 Accidental exposure to other and unspecified factors	0.038	0.961
X50-X57 Overexertion, travel and privation	0.038	0.961
X40-X49 Accidental poisoning by and exposure to noxious substances	0.038	0.961
X30-X39 Exposure to forces of nature	0.038	0.961
X20-X29 Contact with venomous animals and plants	0.038	0.961
X10-X19 Contact with heat and hot substances	0.038	0.961
X00-X09 Exposure to smoke, fire and flames	0.038	0.961
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure	0.038	0.961
W75-W84 Other accidental threats to breathing	0.038	0.961
W65-W74 Accidental drowning and submersion	0.038	0.961
W50-W64 Exposure to animate mechanical forces	0.038	0.961
W20-W49 Exposure to inanimate mechanical forces	0.038	0.961
W00-W19 Falls	0.038	0.961
V98-V99 Other and unspecified transport accidents	0.038	0.961
V95-V97 Air and space transport accidents	0.038	0.961
V90-V94 Water transport accidents	0.038	0.961
V80-V89 Other land transport accidents	0.038	0.961
V70-V79 Bus occupant injured in transport accident	0.038	0.961
V60-V69 Occupant of heavy transport vehicle injured in transport accident	0.038	0.961
V50-V59 Occupant of pick-up truck or van injured in transport accident	0.038	0.961
V40-V49 Car occupant injured in transport accident	0.038	0.961
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident	0.038	0.961
V20-V29 Motorcycle rider injured in transport accident	0.038	0.961
V10-V19 Pedal cyclist injured in transport accident	0.038	0.961
V01-V09 Pedestrian injured in transport accident	0.038	0.961
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.038	0.961
I78 Diseases of capillaries	0.038	0.961
I77 Other disorders of arteries and arterioles	0.038	0.961
I74 Arterial embolism and thrombosis	0.038	0.961
I72 Other aneurysm	0.038	0.961
I71 Aortic aneurysm and dissection	0.038	0.961
I70 Atherosclerosis	0.038	0.961
J90-J94 Other diseases of pleura	0.038	0.961
I15 Secondary hypertension	0.038	0.962
I13 Hypertensive heart and renal disease	0.038	0.962
I12 Hypertensive renal disease	0.038	0.962
I11 Hypertensive heart disease	0.038	0.962
O94-O99 Other obstetric conditions, not elsewhere classified	0.038	0.962
O85-O92 Complications predominantly related to the puerperium	0.038	0.962
O80-O84 Delivery	0.038	0.962
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems	0.038	0.962
O20-O29 Other maternal disorders predominantly related to pregnancy	0.038	0.962
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium	0.038	0.962
O00-O08 Pregnancy with abortive outcome	0.038	0.962
E03 Other hypothyroidism	0.038	0.962
T80-T88 Complications of surgical and medical care, not elsewhere classified	0.038	0.962
D10-D36 Benign neoplasms	0.038	0.962
D37-D48 Neoplasms of uncertain or unknown behaviour	0.038	0.962
D00-D09 In situ neoplasms	0.038	0.962
C97-C97 Malignant neoplasms of independent (primary) multiple sites	0.038	0.962
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue	0.038	0.962
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites	0.038	0.962
C73-C75 Malignant neoplasms of thyroid and other endocrine glands	0.038	0.962
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system	0.038	0.962
C64-C68 Malignant neoplasms of urinary tract	0.038	0.962
C51-C58 Malignant neoplasms of female genital organs	0.038	0.962
C45-C49 Malignant neoplasms of mesothelial and soft tissue	0.038	0.962
C40-C41 Malignant neoplasms of bone and articular cartilage	0.038	0.962
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs	0.038	0.962
C15-C26 Malignant neoplasms of digestive organs	0.038	0.962
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx	0.038	0.962
M20-M25 Other joint disorders	0.038	0.962
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.038	0.962
T79-T79 Certain early complications of trauma	0.038	0.962
T66-T78 Other and unspecified effects of external causes	0.038	0.962
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.038	0.962
T36-T50 Poisoning by drugs, medicaments and biological substances	0.038	0.962
T33-T35 Frostbite	0.038	0.962
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.038	0.962
T26-T28 Burns and corrosions confined to eye and internal organs	0.038	0.962
T20-T25 Burns and corrosions of external body surface, specified by site	0.038	0.962
T15-T19 Effects of foreign body entering through natural orifice	0.038	0.962
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.038	0.962
T00-T07 Injuries involving multiple body regions	0.038	0.962
S90-S99 Injuries to the ankle and foot	0.038	0.962
S80-S89 Injuries to the knee and lower leg	0.038	0.962
S70-S79 Injuries to the hip and thigh	0.038	0.962
S60-S69 Injuries to the wrist and hand	0.038	0.962
S40-S49 Injuries to the shoulder and upper arm	0.038	0.962
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.038	0.962
S20-S29 Injuries to the thorax	0.038	0.962
S10-S19 Injuries to the neck	0.038	0.962
S00-S09 Injuries to the head	0.038	0.962
R94 Abnormal results of function studies	0.038	0.962
I28 Other diseases of pulmonary vessels	0.038	0.962
I27 Other pulmonary heart diseases	0.038	0.962
R16 Hepatomegaly and splenomegaly, not elsewhere classified	0.038	0.962
R18 Ascites	0.038	0.962
R17 Unspecified jaundice	0.038	0.962
R15 Faecal incontinence	0.038	0.962
R14 Flatulence and related conditions	0.038	0.962
R12 Heartburn	0.038	0.962
I21.9 Acute myocardial infarction, unspecified	0.038	0.962
Z72.0 Tobacco use	0.038	0.962
R46 Symptoms and signs involving appearance and behaviour	0.038	0.962
R45 Symptoms and signs involving emotional state	0.038	0.962
R44 Other symptoms and signs involving general sensations and perceptions	0.038	0.962
R43 Disturbances of smell and taste	0.038	0.962
R41 Other symptoms and signs involving cognitive functions and awareness	0.038	0.962
R40 Somnolence, stupor and coma	0.038	0.962
Z30-Z39 Persons encountering health services in circumstances related to reproduction	0.038	0.962
K51 Ulcerative colitis	0.037	0.962
J09-J18 Influenza and pneumonia	0.037	0.962
K25 Gastric ulcer	0.037	0.962
K92.1 Melaena	0.037	0.963
N18 Chronic renal failure	0.037	0.963
B95-B98 Bacterial, viral and other infectious agents	0.037	0.963
K92.2 Gastro-intestinal haemorrhage, unspecified	0.037	0.963
M15-M19 Arthrosis	0.037	0.963
I89 Other non-infective disorders of lymphatic vessels and lymph nodes	0.037	0.963
I88 Nonspecific lymphadenitis	0.037	0.963
I87 Other disorders of veins	0.037	0.963
I86 Varicose veins of other sites	0.037	0.963
I85 Oesophageal varices	0.037	0.963
I82 Other venous embolism and thrombosis	0.037	0.963
I81 Portal vein thrombosis	0.037	0.963
H90-H95 Other disorders of ear	0.037	0.963
H80-H83 Diseases of inner ear	0.037	0.963
H65-H75 Diseases of middle ear and mastoid	0.037	0.963
H60-H62 Diseases of external ear	0.037	0.963
P90-P96 Other disorders originating in the perinatal period	0.037	0.963
P80-P83 Conditions involving the integument and temperature regulation of fetus and newborn	0.037	0.963
P75-P78 Digestive system disorders of fetus and newborn	0.037	0.963
P70-P74 Transitory endocrine and metabolic disorders specific to fetus and newborn	0.037	0.963
P50-P61 Haemorrhagic and haematological disorders of fetus and newborn	0.037	0.963
P35-P39 Infections specific to the perinatal period	0.037	0.963
P20-P29 Respiratory and cardiovascular disorders specific to the perinatal period	0.037	0.963
P10-P15 Birth trauma	0.037	0.963
P05-P08 Disorders related to length of gestation and fetal growth	0.037	0.963
P00-P04 Fetus and newborn affected by maternal factors and by complications of pregnancy, labour and delivery	0.037	0.963
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.037	0.963
Q80-Q89 Other congenital malformations	0.037	0.963
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.037	0.963
Q60-Q64 Congenital malformations of the urinary system	0.037	0.963
Q50-Q56 Congenital malformations of genital organs	0.037	0.963
Q38-Q45 Other congenital malformations of the digestive system	0.037	0.963
Q35-Q37 Cleft lip and cleft palate	0.037	0.963
Q30-Q34 Congenital malformations of the respiratory system	0.037	0.963
Q20-Q28 Congenital malformations of the circulatory system	0.037	0.963
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.037	0.963
Q00-Q07 Congenital malformations of the nervous system	0.037	0.963
U82-U85 Resistance to antimicrobial and antineoplastic drugs	0.037	0.963
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use	0.037	0.963
D80-D89 Certain disorders involving the immune mechanism	0.037	0.963
D70-D77 Other diseases of blood and blood-forming organs	0.037	0.963
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.037	0.963
D55-D59 Haemolytic anaemias	0.037	0.963
B99-B99 Other infectious diseases	0.037	0.963
B90-B94 Sequelae of infectious and parasitic diseases	0.037	0.963
B85-B89 Pediculosis, acariasis and other infestations	0.037	0.963
B65-B83 Helminthiases	0.037	0.963
B50-B64 Protozoal diseases	0.037	0.963
B35-B49 Mycoses	0.037	0.963
B25-B34 Other viral diseases	0.037	0.963
B20-B24 Human immunodeficiency virus [HIV] disease	0.037	0.963
B15-B19 Viral hepatitis	0.037	0.963
B00-B09 Viral infections characterized by skin and mucous membrane lesions	0.037	0.963
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers	0.037	0.963
A80-A89 Viral infections of the central nervous system	0.037	0.963
A75-A79 Rickettsioses	0.037	0.963
A70-A74 Other diseases caused by chlamydiae	0.037	0.963
A65-A69 Other spirochaetal diseases	0.037	0.963
A50-A64 Infections with a predominantly sexual mode of transmission	0.037	0.963
A30-A49 Other bacterial diseases	0.037	0.963
A20-A28 Certain zoonotic bacterial diseases	0.037	0.963
A15-A19 Tuberculosis	0.037	0.963
R78 Findings of drugs and other substances, not normally found in blood	0.037	0.963
R77 Other abnormalities of plasma proteins	0.037	0.963
R76 Other abnormal immunological findings in serum	0.037	0.963
R74 Abnormal serum enzyme levels	0.037	0.963
R73 Elevated blood glucose level	0.037	0.963
R70 Elevated erythrocyte sedimentation rate and abnormality of plasma viscosity	0.037	0.963
R75 Laboratory evidence of human immunodeficiency virus [HIV]	0.037	0.963
R72 Abnormality of white blood cells, not elsewhere classified	0.037	0.963
R71 Abnormality of red blood cells	0.037	0.963
K93 Disorders of other digestive organs in diseases classified elsewhere	0.037	0.963
K91 Postprocedural disorders of digestive system, not elsewhere classified	0.037	0.963
K90 Intestinal malabsorption	0.037	0.963
L98 Other disorders of skin and subcutaneous tissue, not elsewhere classified	0.037	0.963
I84 Haemorrhoids	0.037	0.963
R09 Other symptoms and signs involving the circulatory and respiratory systems	0.037	0.963
R04 Haemorrhage from respiratory passages	0.037	0.963
R03 Abnormal blood-pressure reading, without diagnosis	0.037	0.963
R01 Cardiac murmurs and other cardiac sounds	0.037	0.963
R05 Cough	0.037	0.963
R02 Gangrene, not elsewhere classified	0.037	0.963
Z40-Z54 Persons encountering health services for specific procedures and health care	0.037	0.963
I02 Rheumatic chorea	0.037	0.963
I01 Rheumatic fever with heart involvement	0.037	0.963
I00 Rheumatic fever without mention of heart involvement	0.037	0.963
I09 Other rheumatic heart diseases	0.037	0.963
I08 Multiple valve diseases	0.037	0.963
I07 Rheumatic tricuspid valve diseases	0.037	0.963
I06 Rheumatic aortic valve diseases	0.037	0.963
I05 Rheumatic mitral valve diseases	0.037	0.963
I69 Sequelae of cerebrovascular disease	0.037	0.963
I68 Cerebrovascular disorders in diseases classified elsewhere	0.037	0.963
I67 Other cerebrovascular diseases	0.037	0.963
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction	0.037	0.963
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction	0.037	0.963
I63 Cerebral infarction	0.037	0.963
I62 Other nontraumatic intracranial haemorrhage	0.037	0.963
I61 Intracerebral haemorrhage	0.037	0.963
I60 Subarachnoid haemorrhage	0.037	0.963
I64 Stroke, not specified as haemorrhage or infarction	0.037	0.963
H55-H59 Other disorders of eye and adnexa	0.037	0.963
H53-H54 Visual disturbances and blindness	0.037	0.963
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction	0.037	0.963
H46-H48 Disorders of optic nerve and visual pathways	0.037	0.963
H43-H45 Disorders of vitreous body and globe	0.037	0.963
H40-H42 Glaucoma	0.037	0.963
H30-H36 Disorders of choroid and retina	0.037	0.963
H15-H22 Disorders of sclera, cornea, iris and ciliary body	0.037	0.963
H10-H13 Disorders of conjunctiva	0.037	0.963
H00-H06 Disorders of eyelid, lacrimal system and orbit	0.037	0.963
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances	0.037	0.963
Z20-Z29 Persons with potential health hazards related to communicable diseases	0.037	0.963
K55-K64 Other diseases of intestines	0.037	0.963
A00-A09 Intestinal infectious diseases	0.036	0.963
R69 Unknown and unspecified causes of morbidity	0.036	0.964
R10 Abdominal and pelvic pain	0.036	0.964
L82 Seborrhoeic keratosis	0.036	0.964
I83 Varicose veins of lower extremities	0.036	0.964
H25-H28 Disorders of lens	0.036	0.964
J95-J99 Other diseases of the respiratory system	0.036	0.964
J85-J86 Suppurative and necrotic conditions of lower respiratory tract	0.036	0.964
J80-J84 Other respiratory diseases principally affecting the interstitium	0.036	0.964
J60-J70 Lung diseases due to external agents	0.036	0.964
J30-J39 Other diseases of upper respiratory tract	0.036	0.964
J00-J06 Acute upper respiratory infections	0.036	0.964
R93 Abnormal findings on diagnostic imaging of other body structures	0.036	0.964
R90 Abnormal findings on diagnostic imaging of central nervous system	0.036	0.964
R92 Abnormal findings on diagnostic imaging of breast	0.036	0.964
R91 Abnormal findings on diagnostic imaging of lung	0.036	0.964
I21.X Presumed acute myicardial infaction (unconfirmed)	0.036	0.964
I21.4 Acute subendocardial myocardial infarction	0.036	0.964
I21.3 Acute transmural myocardial infarction of unspecified site	0.036	0.964
I21.2 Acute transmural myocardial infarction of other sites	0.036	0.964
I21.1 Acute transmural myocardial infarction of inferior wall	0.036	0.964
I21.0 Acute transmural myocardial infarction of anterior wall	0.036	0.964
K42 Umbilical hernia	0.036	0.964
Z72.1 Alcohol use	0.035	0.965
I47.9 Paroxysmal tachycardia, unspecified	0.035	0.965
I47.2 Ventricular tachycardia	0.035	0.965
I47.0 Reentry ventricular arrhythmia	0.035	0.965
R63 Symptoms and signs concerning food and fluid intake	0.035	0.965
N37 Urethral disorders in diseases classified elsewhere	0.035	0.965
N36 Other disorders of urethra	0.035	0.965
N34 Urethritis and urethral syndrome	0.035	0.965
N33 Bladder disorders in diseases classified elsewhere	0.035	0.965
N31 Neuromuscular dysfunction of bladder, not elsewhere classified	0.035	0.965
N30 Cystitis	0.035	0.965
R06 Abnormalities of breathing	0.035	0.965
I50.9 Heart failure, unspecified	0.035	0.965
I50.0 Congestive heart failure	0.035	0.965
K31 Other diseases of stomach and duodenum	0.035	0.965
K28 Gastrojejunal ulcer	0.035	0.965
K27 Peptic ulcer, site unspecified	0.035	0.965
K26 Duodenal ulcer	0.035	0.965
K23 Disorders of oesophagus in diseases classified elsewhere	0.035	0.965
K22 Other diseases of oesophagus	0.035	0.965
D60-D64 Aplastic and other anaemias	0.035	0.965
R23 Other skin changes	0.035	0.965
R22 Localised swelling, mass and lump of skin and subcutaneous tissue	0.035	0.965
R20 Disturbances of skin sensation	0.035	0.965
R21 Rash and other nonspecific skin eruption	0.035	0.965
R29 Other symptoms and signs involving the nervous and musculoskeletal systems	0.035	0.965
R27 Other lack of coordination	0.035	0.965
R26 Abnormalities of gait and mobility	0.035	0.965
R25 Abnormal involuntary movements	0.035	0.965
R49 Voice disturbances	0.035	0.965
R48 Dyslexia and other symbolic dysfunctions, not elsewhere classified	0.035	0.965
R47 Speech disturbances, not elsewhere classified	0.035	0.965
R82 Other abnormal findings in urine	0.035	0.965
R81 Glycosuria	0.035	0.965
R80 Isolated proteinuria	0.035	0.965
R89 Abnormal findings in specimens from other organs, systems and tissues	0.035	0.965
R87 Abnormal findings in specimens from female genital organs	0.035	0.965
R86 Abnormal findings in specimens from male genital organs	0.035	0.965
R85 Abnormal findings in specimens from digestive organs and abdominal cavity	0.035	0.965
R84 Abnormal findings in specimens from respiratory organs and thorax	0.035	0.965
R83 Abnormal findings in cerebrospinal fluid	0.035	0.965
R96 Other sudden death, cause unknown	0.035	0.965
R95 Sudden infant death syndrome	0.035	0.965
R99 Other ill-defined and unspecified causes of mortality	0.035	0.965
R98 Unattended death	0.035	0.965
G90-G99 Other disorders of the nervous system	0.034	0.965
G80-G83 Cerebral palsy and other paralytic syndromes	0.034	0.965
G70-G73 Diseases of myoneural junction and muscle	0.034	0.965
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system	0.034	0.965
G40-G47 Episodic and paroxysmal disorders	0.034	0.965
G35-G37 Demyelinating diseases of the central nervous system	0.034	0.965
G30-G32 Other degenerative diseases of the nervous system	0.034	0.965
G20-G26 Extrapyramidal and movement disorders	0.034	0.965
G10-G14 Systemic atrophies primarily affecting the central nervous system	0.034	0.965
G00-G09 Inflammatory diseases of the central nervous system	0.034	0.965
I22.9 Subsequent myocardial infarction of unspecified site	0.034	0.965
I22.8 Subsequent myocardial infarction of other sites	0.034	0.965
I22.1 Subsequent myocardial infarction of inferior wall	0.034	0.965
I22.0 Subsequent myocardial infarction of anterior wall	0.034	0.965
I23.8 Other current complications following acute myocardial infarction	0.034	0.965
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction	0.034	0.965
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction	0.034	0.965
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction	0.034	0.965
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction	0.034	0.965
I23.2 Ventricular septal defect as current complication following acute myocardial infarction	0.034	0.965
I23.1 Atrial septal defect as current complication following acute myocardial infarction	0.034	0.965
I23.0 Haemopericardium as current complication following acute myocardial infarction	0.034	0.965
I24.9 Acute ischaemic heart disease, unspecified	0.034	0.965
I24.8 Other forms of acute ischaemic heart disease	0.034	0.965
I24.1 Dressler's syndrome	0.034	0.965
I24.0 Coronary thrombosis not resulting in myocardial infarction	0.034	0.965
C50-C50 Malignant neoplasm of breast	0.034	0.966
J40-J47 Chronic lower respiratory diseases	0.034	0.966
Z00-Z13 Persons encountering health services for examination and investigation	0.034	0.966
K50 Crohn's disease [regional enteritis]	0.034	0.966
E10 Insulin-dependent diabetes mellitus	0.034	0.966

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations