TreeWAS – Variant ID: rs12371484

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
I20-I25 Ischaemic heart diseases	1.000	0.000	0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	1.000	0.000	0.000
Chapter IX Diseases of the circulatory system	1.000	0.000	0.000
# Top node	1.000	0.000	0.000
I25 Chronic ischaemic heart disease	1.000	0.000	0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour	1.000	0.000	0.000
Chapter VI Diseases of the nervous system	1.000	0.000	0.000
I60-I69 Cerebrovascular diseases	1.000	0.000	0.000
G40-G47 Episodic and paroxysmal disorders	1.000	0.000	0.000
R42 Dizziness and giddiness	1.000	0.000	0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.999	0.001	0.000
R50-R69 General symptoms and signs	0.999	0.001	0.000
R55 Syncope and collapse	0.997	0.003	0.000
I25.1 Atherosclerotic heart disease	0.997	0.003	0.000
R56 Convulsions, not elsewhere classified	0.997	0.003	0.000
G43 Migraine	0.996	0.004	0.000
I25.8 Other forms of chronic ischaemic heart disease	0.996	0.004	0.000
R56.8 Other and unspecified convulsions	0.995	0.005	0.000
Chapter XX External causes of morbidity and mortality	0.994	0.006	0.000
G43.9 Migraine, unspecified	0.993	0.007	0.000
I21 Acute myocardial infarction	0.986	0.014	0.000
G40 Epilepsy	0.986	0.014	0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.985	0.015	0.000
I25.9 Chronic ischaemic heart disease, unspecified	0.984	0.016	0.000
I67 Other cerebrovascular diseases	0.981	0.019	0.000
S00-S09 Injuries to the head	0.975	0.025	0.000
I61 Intracerebral haemorrhage	0.965	0.035	0.000
I63 Cerebral infarction	0.961	0.039	0.000
G40.9 Epilepsy, unspecified	0.960	0.040	0.000
I21.1 Acute transmural myocardial infarction of inferior wall	0.960	0.040	0.000
G20-G26 Extrapyramidal and movement disorders	0.959	0.041	0.000
R40 Somnolence, stupor and coma	0.958	0.042	0.000
I70-I79 Diseases of arteries, arterioles and capillaries	0.956	0.044	0.000
I05-I09 Chronic rheumatic heart diseases	0.955	0.045	0.000
I20 Angina pectoris	0.952	0.048	0.000
R54 Senility	0.952	0.048	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.949	0.051	0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs	0.948	0.052	0.000
I67.9 Cerebrovascular disease, unspecified	0.946	0.054	0.000
E00-E07 Disorders of thyroid gland	0.944	0.056	0.000
E03 Other hypothyroidism	0.941	0.059	0.000
E03.9 Hypothyroidism, unspecified	0.941	0.059	0.000
I21.0 Acute transmural myocardial infarction of anterior wall	0.937	0.063	0.000
S02 Fracture of skull and facial bones	0.933	0.067	0.000
G45 Transient cerebral ischaemic attacks and related syndromes	0.930	0.070	0.000
T36-T50 Poisoning by drugs, medicaments and biological substances	0.925	0.075	0.000
I63.5 Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries	0.919	0.081	0.000
G20 Parkinson's disease	0.918	0.082	0.000
I08 Multiple valve diseases	0.908	0.092	0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis	0.908	0.092	0.000
I20.9 Angina pectoris, unspecified	0.901	0.099	0.000
I69 Sequelae of cerebrovascular disease	0.899	0.101	0.000
Y44 Agents primarily affecting blood constituents	0.898	0.102	0.000
I22 Subsequent myocardial infarction	0.898	0.102	0.000
Y40 Systemic antibiotics	0.896	0.104	0.000
I61.9 Intracerebral haemorrhage, unspecified	0.896	0.104	0.000
G00-G09 Inflammatory diseases of the central nervous system	0.893	0.107	0.000
G80-G83 Cerebral palsy and other paralytic syndromes	0.890	0.110	0.000
E20-E35 Disorders of other endocrine glands	0.889	0.111	0.000
I64 Stroke, not specified as haemorrhage or infarction	0.886	0.114	0.000
I77 Other disorders of arteries and arterioles	0.885	0.115	0.000
S02.4 Fracture of malar and maxillary bones	0.884	0.116	0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.880	0.120	0.000
I08.1 Disorders of both mitral and tricuspid valves	0.880	0.120	0.000
I67.2 Cerebral atherosclerosis	0.879	0.121	0.000
Y45.0 Opioids and related analgesics	0.873	0.127	0.000
R44 Other symptoms and signs involving general sensations and perceptions	0.872	0.128	0.000
W00-W19 Falls	0.868	0.132	0.000
I63.9 Cerebral infarction, unspecified	0.866	0.134	0.000
E27 Other disorders of adrenal gland	0.865	0.135	0.000
I73 Other peripheral vascular diseases	0.864	0.136	0.000
G40.2 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures	0.861	0.139	0.000
S90-S99 Injuries to the ankle and foot	0.861	0.139	0.000
I69.3 Sequelae of cerebral infarction	0.858	0.142	0.000
S05 Injury of eye and orbit	0.858	0.142	0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs	0.858	0.142	0.000
X40-X49 Accidental poisoning by and exposure to noxious substances	0.858	0.142	0.000
G45.4 Transient global amnesia	0.857	0.143	0.000
S40-S49 Injuries to the shoulder and upper arm	0.856	0.144	0.000
R40.0 Somnolence	0.854	0.146	0.000
R93 Abnormal findings on diagnostic imaging of other body structures	0.853	0.147	0.000
S10-S19 Injuries to the neck	0.852	0.148	0.000
S02.40 Fracture of malar and maxillary bones (closed)	0.849	0.151	0.000
Y48 Anaesthetics and therapeutic gases	0.849	0.151	0.000
R40.2 Coma, unspecified	0.845	0.155	0.000
Y44.2 Anticoagulants	0.836	0.164	0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere	0.835	0.165	0.000
I67.8 Other specified cerebrovascular diseases	0.835	0.165	0.000
I10-I15 Hypertensive diseases	0.834	0.166	0.000
E27.4 Other and unspecified adrenocortical insufficiency	0.826	0.174	0.000
E07 Other disorders of thyroid	0.826	0.174	0.000
G24 Dystonia	0.824	0.176	0.000
T20-T25 Burns and corrosions of external body surface, specified by site	0.823	0.177	0.000
I72 Other aneurysm	0.821	0.179	0.000
R93.8 Abnormal findings on diagnostic imaging of other specified body structures	0.818	0.182	0.000
R45 Symptoms and signs involving emotional state	0.818	0.182	0.000
I24 Other acute ischaemic heart diseases	0.816	0.184	0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.813	0.187	0.000
I07 Rheumatic tricuspid valve diseases	0.811	0.189	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.803	0.197	0.000
R44.3 Hallucinations, unspecified	0.801	0.199	0.000
I61.5 Intracerebral haemorrhage, intraventricular	0.799	0.201	0.000
G04 Encephalitis, myelitis and encephalomyelitis	0.797	0.203	0.000
Chapter VIII Diseases of the ear and mastoid process	0.797	0.203	0.000
I77.6 Arteritis, unspecified	0.796	0.204	0.000
I62 Other nontraumatic intracranial haemorrhage	0.792	0.207	0.000
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level	0.792	0.208	0.000
I61.2 Intracerebral haemorrhage in hemisphere, unspecified	0.791	0.209	0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.790	0.210	0.000
V40-V49 Car occupant injured in transport accident	0.788	0.212	0.000
G41 Status epilepticus	0.788	0.212	0.000
Y45.5 4-Aminophenol derivatives	0.787	0.213	0.000
G40.3 Generalised idiopathic epilepsy and epileptic syndromes	0.785	0.215	0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use	0.784	0.216	0.000
T91 Sequelae of injuries of neck and trunk	0.782	0.218	0.000
Y45.2 Propionic acid derivatives	0.782	0.218	0.000
R93.7 Abnormal findings on diagnostic imaging of other parts of musculoskeletal system	0.781	0.219	0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.781	0.219	0.000
R65 Systemic Inflammatory Response Syndrome [SIRS]	0.779	0.221	0.000
M45-M49 Spondylopathies	0.779	0.221	0.000
R46 Symptoms and signs involving appearance and behaviour	0.778	0.221	0.000
Chapter V Mental and behavioural disorders	0.777	0.223	0.000
I22.9 Subsequent myocardial infarction of unspecified site	0.776	0.224	0.000
G40.8 Other epilepsy	0.773	0.227	0.000
I70 Atherosclerosis	0.772	0.228	0.000
R40.1 Stupor	0.770	0.230	0.000
Y52 Agents primarily affecting the cardiovascular system	0.770	0.230	0.000
I25.4 Coronary artery aneurysm	0.770	0.230	0.000
G44 Other headache syndromes	0.769	0.231	0.000
R43 Disturbances of smell and taste	0.768	0.232	0.000
I73.0 Raynaud's syndrome	0.768	0.232	0.000
W50-W64 Exposure to animate mechanical forces	0.767	0.233	0.000
T46 Poisoning by agents primarily affecting the cardiovascular system	0.767	0.233	0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified	0.766	0.234	0.000
I20.8 Other forms of angina pectoris	0.765	0.235	0.000
I08.8 Other multiple valve diseases	0.763	0.237	0.000
R30-R39 Symptoms and signs involving the urinary system	0.762	0.238	0.000
R94 Abnormal results of function studies	0.762	0.238	0.000
R39.8 Other and unspecified symptoms and signs involving the urinary system	0.762	0.238	0.000
G45.9 Transient cerebral ischaemic attack, unspecified	0.761	0.239	0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction	0.760	0.240	0.000
R39 Other symptoms and signs involving the urinary system	0.760	0.240	0.000
X41 Accidental poisoning by and exposure to antiepileptic, sedative-hypnotic, anti-Parkinsonism and psychotropic drugs, not elsewhere classified	0.760	0.240	0.000
I22.1 Subsequent myocardial infarction of inferior wall	0.759	0.241	0.000
M20-M25 Other joint disorders	0.758	0.242	0.000
G43.1 Migraine with aura [classical migraine]	0.756	0.244	0.000
S02.3 Fracture of orbital floor	0.756	0.244	0.000
S20-S29 Injuries to the thorax	0.756	0.244	0.000
S13 Dislocation, sprain and strain of joints and ligaments at neck level	0.754	0.246	0.000
R64 Cachexia	0.753	0.246	0.000
T42.4 Benzodiazepines	0.753	0.247	0.000
T36 Poisoning by systemic antibiotics	0.752	0.248	0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts	0.752	0.248	0.000
S00 Superficial injury of head	0.751	0.249	0.000
Y40.0 Penicillins	0.750	0.250	0.000
I21.4 Acute subendocardial myocardial infarction	0.750	0.250	0.000
M25 Other joint disorders, not elsewhere classified	0.749	0.251	0.000
E27.1 Primary adrenocortical insufficiency	0.747	0.253	0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs	0.747	0.253	0.000
W17 Other fall from one level to another	0.747	0.253	0.000
G81 Hemiplegia	0.746	0.254	0.000
R59 Enlarged lymph nodes	0.746	0.254	0.000
G83 Other paralytic syndromes	0.744	0.256	0.000
V80-V89 Other land transport accidents	0.742	0.258	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.742	0.258	0.000
S06 Intracranial injury	0.739	0.261	0.000
Y45.1 Salicylates	0.739	0.261	0.000
M25.5 Pain in joint	0.739	0.261	0.000
W13 Fall from, out of or through building or structure	0.736	0.263	0.000
G45.0 Vertebro-basilar artery syndrome	0.736	0.264	0.000
I77.1 Stricture of artery	0.736	0.264	0.000
R63 Symptoms and signs concerning food and fluid intake	0.735	0.265	0.000
M25.55 Pain in joint (Pelvic region and thigh)	0.733	0.267	0.000
I61.0 Intracerebral haemorrhage in hemisphere, subcortical	0.733	0.267	0.000
Y40.9 Systemic antibiotic, unspecified	0.732	0.268	0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]	0.731	0.269	0.000
M46 Other inflammatory spondylopathies	0.730	0.270	0.000
G04.9 Encephalitis, myelitis and encephalomyelitis, unspecified	0.729	0.271	0.000
X10-X19 Contact with heat and hot substances	0.727	0.273	0.000
I69.0 Sequelae of subarachnoid haemorrhage	0.724	0.276	0.000
T79-T79 Certain early complications of trauma	0.723	0.276	0.000
I21.9 Acute myocardial infarction, unspecified	0.723	0.277	0.000
Y95 Nosocomial condition	0.722	0.278	0.000
X60-X84 Intentional self-harm	0.721	0.279	0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs	0.721	0.279	0.000
S05.1 Contusion of eyeball and orbital tissues	0.720	0.280	0.000
G40.6 Grand mal seizures, unspecified (with or without petit mal)	0.720	0.280	0.000
T92 Sequelae of injuries of upper limb	0.719	0.280	0.000
G35-G37 Demyelinating diseases of the central nervous system	0.719	0.281	0.000
S02.0 Fracture of vault of skull	0.717	0.283	0.000
I25.6 Silent myocardial ischaemia	0.717	0.283	0.000
I23 Certain current complications following acute myocardial infarction	0.717	0.283	0.000
I00-I02 Acute rheumatic fever	0.717	0.283	0.000
R95-R99 Ill-defined and unknown causes of mortality	0.717	0.283	0.000
Chapter XVI Certain conditions originating in the perinatal period	0.717	0.283	0.000
I68 Cerebrovascular disorders in diseases classified elsewhere	0.717	0.283	0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction	0.717	0.283	0.000
G46 Vascular syndromes of brain in cerebrovascular diseases	0.717	0.283	0.000
Y40.3 Macrolides	0.717	0.283	0.000
I63.2 Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries	0.717	0.283	0.000
T33-T35 Frostbite	0.717	0.283	0.000
T26-T28 Burns and corrosions confined to eye and internal organs	0.717	0.283	0.000
R62 Lack of expected normal physiological development	0.716	0.284	0.000
R56.0 Febrile convulsions	0.714	0.285	0.000
G70-G73 Diseases of myoneural junction and muscle	0.714	0.286	0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.714	0.286	0.000
G43.8 Other migraine	0.714	0.286	0.000
G43.3 Complicated migraine	0.714	0.286	0.000
G43.2 Status migrainosus	0.714	0.286	0.000
G43.0 Migraine without aura [common migraine]	0.714	0.286	0.000
I22.8 Subsequent myocardial infarction of other sites	0.714	0.286	0.000
T00-T07 Injuries involving multiple body regions	0.713	0.287	0.000
Y35-Y36 Legal intervention and operations of war	0.713	0.287	0.000
Y10-Y34 Event of undetermined intent	0.713	0.287	0.000
X85-X99 Assault	0.713	0.287	0.000
X30-X39 Exposure to forces of nature	0.713	0.287	0.000
X00-X09 Exposure to smoke, fire and flames	0.713	0.287	0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure	0.713	0.287	0.000
W75-W84 Other accidental threats to breathing	0.713	0.287	0.000
W65-W74 Accidental drowning and submersion	0.713	0.287	0.000
V98-V99 Other and unspecified transport accidents	0.713	0.287	0.000
V95-V97 Air and space transport accidents	0.713	0.287	0.000
V90-V94 Water transport accidents	0.713	0.287	0.000
V70-V79 Bus occupant injured in transport accident	0.713	0.287	0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident	0.713	0.287	0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident	0.713	0.287	0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident	0.713	0.287	0.000
V01-V09 Pedestrian injured in transport accident	0.713	0.287	0.000
W07 Fall involving chair	0.713	0.287	0.000
M35 Other systemic involvement of connective tissue	0.712	0.288	0.000
S42 Fracture of shoulder and upper arm	0.710	0.290	0.000
S02.8 Fractures of other skull and facial bones	0.710	0.290	0.000
I07.1 Tricuspid insufficiency	0.708	0.292	0.000
Y00-Y09 Assault	0.707	0.293	0.000
I21.X Presumed acute myicardial infaction (unconfirmed)	0.707	0.293	0.000
S02.1 Fracture of base of skull	0.707	0.293	0.000
G90-G99 Other disorders of the nervous system	0.707	0.293	0.000
G40.7 Petit mal, unspecified, without grand mal seizures	0.707	0.293	0.000
G40.4 Other generalised epilepsy and epileptic syndromes	0.707	0.293	0.000
G40.0 Localisation-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localised onset	0.707	0.293	0.000
Y59 Other and unspecified vaccines and biological substances	0.706	0.294	0.000
Y58 Bacterial vaccines	0.706	0.294	0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system	0.706	0.294	0.000
Y53 Agents primarily affecting the gastro-intestinal system	0.706	0.294	0.000
Y50 Central nervous system stimulants, not elsewhere classified	0.706	0.294	0.000
Y49 Psychotropic drugs, not elsewhere classified	0.706	0.294	0.000
Y47 Sedatives, hypnotics and antianxiety drugs	0.706	0.294	0.000
Y46 Antiepileptics and anti-Parkinsonism drugs	0.706	0.294	0.000
E07.9 Disorder of thyroid, unspecified	0.706	0.294	0.000
X20-X29 Contact with venomous animals and plants	0.705	0.295	0.000
E22 Hyperfunction of pituitary gland	0.705	0.295	0.000
G06 Intracranial and intraspinal abscess and granuloma	0.704	0.296	0.000
I67.7 Cerebral arteritis, not elsewhere classified	0.703	0.297	0.000
I67.6 Nonpyogenic thrombosis of intracranial venous system	0.703	0.297	0.000
I67.5 Moyamoya disease	0.703	0.297	0.000
I67.4 Hypertensive encephalopathy	0.703	0.297	0.000
I67.3 Progressive vascular leukoencephalopathy	0.703	0.297	0.000
I67.0 Dissection of cerebral arteries, nonruptured	0.703	0.297	0.000
H90-H95 Other disorders of ear	0.703	0.297	0.000
S70-S79 Injuries to the hip and thigh	0.701	0.299	0.000
M25.52 Pain in joint (Upper arm)	0.701	0.299	0.000
Y60-Y69 Misadventures to patients during surgical and medical care	0.700	0.300	0.000
I25.0 Atherosclerotic cardiovascular disease, so described	0.699	0.301	0.000
G80 Infantile cerebral palsy	0.699	0.301	0.000
F30-F39 Mood [affective] disorders	0.699	0.301	0.000
S08 Traumatic amputation of part of head	0.699	0.301	0.000
S07 Crushing injury of head	0.699	0.301	0.000
S04 Injury of cranial nerves	0.699	0.301	0.000
S03 Dislocation, sprain and strain of joints and ligaments of head	0.699	0.301	0.000
R58 Haemorrhage, not elsewhere classified	0.699	0.301	0.000
X58-X59 Accidental exposure to other and unspecified factors	0.698	0.302	0.000
M46.9 Inflammatory spondylopathy, unspecified	0.698	0.302	0.000
Y48.2 Other and unspecified general anaesthetics	0.698	0.302	0.000
R68 Other general symptoms and signs	0.697	0.302	0.000
R47-R49 Symptoms and signs involving speech and voice	0.697	0.303	0.000
I25.5 Ischaemic cardiomyopathy	0.695	0.305	0.000
S93.0 Dislocation of ankle joint	0.695	0.305	0.000
I10 Essential (primary) hypertension	0.694	0.306	0.000
I77.0 Arteriovenous fistula, acquired	0.694	0.306	0.000
G30-G32 Other degenerative diseases of the nervous system	0.692	0.308	0.000
I61.6 Intracerebral haemorrhage, multiple localised	0.692	0.308	0.000
I61.4 Intracerebral haemorrhage in cerebellum	0.692	0.308	0.000
I61.3 Intracerebral haemorrhage in brain stem	0.692	0.308	0.000
I61.1 Intracerebral haemorrhage in hemisphere, cortical	0.692	0.308	0.000
Y48.3 Local anaesthetics	0.692	0.308	0.000
G40.5 Special epileptic syndromes	0.691	0.308	0.000
S02.9 Fracture of skull and facial bones, part unspecified	0.691	0.309	0.000
M48 Other spondylopathies	0.691	0.309	0.000
I20.1 Angina pectoris with documented spasm	0.689	0.310	0.000
X41.9 Unspecified place	0.689	0.311	0.000
I63.6 Cerebral infarction due to cerebral venous thrombosis, nonpyogenic	0.689	0.311	0.000
I63.1 Cerebral infarction due to embolism of precerebral arteries	0.689	0.311	0.000
I63.0 Cerebral infarction due to thrombosis of precerebral arteries	0.689	0.311	0.000
G24.9 Dystonia, unspecified	0.687	0.313	0.000
G23 Other degenerative diseases of basal ganglia	0.687	0.313	0.000
G21 Secondary Parkinsonism	0.687	0.313	0.000
G26 Extrapyramidal and movement disorders in diseases classified elsewhere	0.687	0.313	0.000
G22 Parkinsonism in diseases classified elsewhere	0.687	0.313	0.000
S46 Injury of muscle and tendon at shoulder and upper arm level	0.687	0.313	0.000
I20.0 Unstable angina	0.687	0.313	0.000
I09 Other rheumatic heart diseases	0.685	0.315	0.000
I06 Rheumatic aortic valve diseases	0.685	0.315	0.000
S05.3 Ocular laceration without prolapse or loss of intraocular tissue	0.683	0.317	0.000
W10 Fall on and from stairs and steps	0.683	0.317	0.000
Y45.9 Analgesic, antipyretic and anti-inflammatory drug, unspecified	0.680	0.320	0.000
Y45.8 Other analgesics and antipyretics	0.680	0.320	0.000
Y45.4 Antirheumatics	0.680	0.320	0.000
T31 Burns classified according to extent of body surface involved	0.680	0.320	0.000
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts	0.680	0.320	0.000
I69.1 Sequelae of intracerebral haemorrhage	0.678	0.322	0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.676	0.323	0.000
E00 Congenital iodine-deficiency syndrome	0.676	0.323	0.000
E02 Subclinical iodine-deficiency hypothyroidism	0.676	0.323	0.000
R94.5 Abnormal results of liver function studies	0.676	0.324	0.000
H80-H83 Diseases of inner ear	0.676	0.324	0.000
E23 Hypofunction and other disorders of pituitary gland	0.676	0.324	0.000
I62.0 Subdural haemorrhage (acute) (nontraumatic)	0.676	0.324	0.000
X50-X57 Overexertion, travel and privation	0.675	0.324	0.000
M21 Other acquired deformities of limbs	0.675	0.325	0.000
E03.5 Myxoedema coma	0.675	0.325	0.000
E03.4 Atrophy of thyroid (acquired)	0.675	0.325	0.000
E03.3 Postinfectious hypothyroidism	0.675	0.325	0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.675	0.325	0.000
E03.1 Congenital hypothyroidism without goitre	0.675	0.325	0.000
E03.0 Congenital hypothyroidism with diffuse goitre	0.675	0.325	0.000
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle	0.673	0.327	0.000
I61.8 Other intracerebral haemorrhage	0.673	0.327	0.000
E40-E46 Malnutrition	0.672	0.328	0.000
I70.2 Atherosclerosis of arteries of the extremities	0.672	0.328	0.000
I73.9 Peripheral vascular disease, unspecified	0.671	0.329	0.000
F31 Bipolar affective disorder	0.671	0.329	0.000
E06 Thyroiditis	0.670	0.330	0.000
I24.9 Acute ischaemic heart disease, unspecified	0.670	0.330	0.000
S02.7 Multiple fractures involving skull and facial bones	0.669	0.331	0.000
G08 Intracranial and intraspinal phlebitis and thrombophlebitis	0.668	0.332	0.000
G45.2 Multiple and bilateral precerebral artery syndromes	0.666	0.333	0.000
G45.1 Carotid artery syndrome (hemispheric)	0.666	0.333	0.000
I21.3 Acute transmural myocardial infarction of unspecified site	0.666	0.333	0.000
S09 Other and unspecified injuries of head	0.666	0.334	0.000
S02.2 Fracture of nasal bones	0.665	0.335	0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system	0.664	0.336	0.000
S39 Other and unspecified injuries of abdomen, lower back and pelvis	0.664	0.336	0.000
E05 Thyrotoxicosis [hyperthyroidism]	0.664	0.336	0.000
I72.4 Aneurysm of artery of lower extremity	0.663	0.336	0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.663	0.337	0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.663	0.337	0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.663	0.337	0.000
T41 Poisoning by anaesthetics and therapeutic gases	0.663	0.337	0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.663	0.337	0.000
M35.0 Sicca syndrome [Sjogren]	0.662	0.338	0.000
E07.8 Other specified disorders of thyroid	0.661	0.339	0.000
R63.0 Anorexia	0.659	0.341	0.000
T15-T19 Effects of foreign body entering through natural orifice	0.659	0.341	0.000
Q20-Q28 Congenital malformations of the circulatory system	0.659	0.341	0.000
S11 Open wound of neck	0.657	0.343	0.000
I72.8 Aneurysm of other specified arteries	0.657	0.343	0.000
I12 Hypertensive renal disease	0.657	0.343	0.000
M25.7 Osteophyte	0.655	0.345	0.000
S50-S59 Injuries to the elbow and forearm	0.655	0.345	0.000
G24.8 Other dystonia	0.654	0.346	0.000
S05.9 Injury of eye and orbit, part unspecified	0.654	0.346	0.000
I63.4 Cerebral infarction due to embolism of cerebral arteries	0.653	0.347	0.000
Y57 Other and unspecified drugs and medicaments	0.653	0.347	0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.653	0.347	0.000
Y40.8 Other systemic antibiotics	0.653	0.347	0.000
S20 Superficial injury of thorax	0.652	0.347	0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems	0.652	0.348	0.000
I73.8 Other specified peripheral vascular diseases	0.651	0.349	0.000
S42.0 Fracture of clavicle	0.651	0.349	0.000
I08.9 Multiple valve disease, unspecified	0.651	0.349	0.000
R92 Abnormal findings on diagnostic imaging of breast	0.651	0.349	0.000
Y71 Cardiovascular devices associated with adverse incidents	0.651	0.349	0.000
E24 Cushing's syndrome	0.650	0.349	0.000
X45 Accidental poisoning by and exposure to alcohol	0.650	0.350	0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.650	0.350	0.000
R41 Other symptoms and signs involving cognitive functions and awareness	0.650	0.350	0.000
Y43 Primarily systemic agents	0.649	0.351	0.000
R45.8 Other symptoms and signs involving emotional state	0.649	0.351	0.000
T91.9 Sequelae of unspecified injury of neck and trunk	0.649	0.351	0.000
I15 Secondary hypertension	0.648	0.352	0.000
G44.4 Drug-induced headache, not elsewhere classified	0.647	0.353	0.000
W15 Fall from cliff	0.647	0.353	0.000
I74 Arterial embolism and thrombosis	0.647	0.353	0.000
E27.2 Addisonian crisis	0.646	0.354	0.000
I69.2 Sequelae of other nontraumatic intracranial haemorrhage	0.644	0.355	0.000
S80-S89 Injuries to the knee and lower leg	0.644	0.356	0.000
I77.8 Other specified disorders of arteries and arterioles	0.644	0.356	0.000
Y44.9 Other and unspecified agents affecting blood constituents	0.644	0.356	0.000
Y44.7 Plasma substitutes	0.644	0.356	0.000
Y44.6 Natural blood and blood products	0.644	0.356	0.000
Y44.5 Thrombolytic drugs	0.644	0.356	0.000
Y44.4 Antithrombotic drugs [platelet-aggregation inhibitors]	0.644	0.356	0.000
Y44.3 Anticoagulant antagonists, vitamin K and other coagulants	0.644	0.356	0.000
Y44.1 Vitamin B12, folic acid and other anti-megaloblastic-anaemia preparations	0.644	0.356	0.000
Y44.0 Iron preparations and other anti-hypochromic-anaemia preparations	0.644	0.356	0.000
F60-F69 Disorders of adult personality and behaviour	0.644	0.356	0.000
G81.9 Hemiplegia, unspecified	0.644	0.356	0.000
Y40.7 Antifungal antibiotics, systemically used	0.642	0.357	0.000
Y40.6 Rifamycins	0.642	0.357	0.000
Y40.5 Aminoglycosides	0.642	0.357	0.000
Y40.4 Tetracyclines	0.642	0.357	0.000
Y40.2 Chloramphenicol group	0.642	0.357	0.000
Y40.1 Cefalosporins and other -lactam antibiotics	0.642	0.357	0.000
W13.9 Unspecified place	0.642	0.358	0.000
S12 Fracture of neck	0.640	0.359	0.000
G05 Encephalitis, myelitis and encephalomyelitis in diseases classified elsewhere	0.640	0.359	0.000
G02 Meningitis in other infectious and parasitic diseases classified elsewhere	0.640	0.359	0.000
G00 Bacterial meningitis, not elsewhere classified	0.640	0.359	0.000
G09 Sequelae of inflammatory diseases of central nervous system	0.640	0.359	0.000
G07 Intracranial and intraspinal abscess and granuloma in diseases classified elsewhere	0.640	0.359	0.000
G01 Meningitis in bacterial diseases classified elsewhere	0.640	0.359	0.000
T90 Sequelae of injuries of head	0.640	0.360	0.000
S93.1 Dislocation of toe(s)	0.639	0.361	0.000
M48.5 Collapsed vertebra, not elsewhere classified	0.638	0.362	0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.638	0.362	0.000
E35 Disorders of endocrine glands in diseases classified elsewhere	0.637	0.363	0.000
E32 Diseases of thymus	0.637	0.363	0.000
E31 Polyglandular dysfunction	0.637	0.363	0.000
E30 Disorders of puberty, not elsewhere classified	0.637	0.363	0.000
E25 Adrenogenital disorders	0.637	0.363	0.000
E20 Hypoparathyroidism	0.637	0.363	0.000
G45.8 Other transient cerebral ischaemic attacks and related syndromes	0.636	0.363	0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.637	0.363	0.000
I08.2 Disorders of both aortic and tricuspid valves	0.636	0.364	0.000
V10-V19 Pedal cyclist injured in transport accident	0.635	0.364	0.000
G41.9 Status epilepticus, unspecified	0.635	0.365	0.000
I77.5 Necrosis of artery	0.635	0.365	0.000
I77.4 Coeliac artery compression syndrome	0.635	0.365	0.000
I77.3 Arterial fibromuscular dysplasia	0.635	0.365	0.000
I77.2 Rupture of artery	0.635	0.365	0.000
I72.9 Aneurysm of unspecified site	0.634	0.366	0.000
E27.9 Disorder of adrenal gland, unspecified	0.634	0.366	0.000
T21 Burn and corrosion of trunk	0.634	0.366	0.000
W17.4 Street and highway	0.634	0.366	0.000
S02.41 Fracture of malar and maxillary bones (open)	0.634	0.366	0.000
T13 Other injuries of lower limb, level unspecified	0.633	0.366	0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction	0.633	0.367	0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.633	0.367	0.000
R44.8 Other and unspecified symptoms and signs involving general sensations and perceptions	0.632	0.368	0.000
S13.4 Sprain and strain of cervical spine	0.631	0.369	0.000
T98 Sequelae of other and unspecified effects of external causes	0.631	0.369	0.000
T95 Sequelae of burns, corrosions and frostbite	0.631	0.369	0.000
T94 Sequelae of injuries involving multiple and unspecified body regions	0.631	0.369	0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source	0.631	0.369	0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances	0.631	0.369	0.000
T91.1 Sequelae of fracture of spine	0.631	0.369	0.000
S13.1 Dislocation of cervical vertebra	0.630	0.369	0.000
T92.1 Sequelae of fracture of arm	0.629	0.371	0.000
S90 Superficial injury of ankle and foot	0.629	0.371	0.000
T36.0 Penicillins	0.629	0.371	0.000
S02.30 Fracture of orbital floor (closed)	0.629	0.371	0.000
H35.3 Degeneration of macula and posterior pole	0.000	0.371	0.629
R93.5 Abnormal findings on diagnostic imaging of other abdominal regions, including retroperitoneum	0.627	0.373	0.000
T24 Burn and corrosion of hip and lower limb, except ankle and foot	0.627	0.373	0.000
S31 Open wound of abdomen, lower back and pelvis	0.626	0.374	0.000
R44.2 Other hallucinations	0.626	0.374	0.000
S93.3 Dislocation of other and unspecified parts of foot	0.625	0.375	0.000
S91 Open wound of ankle and foot	0.625	0.375	0.000
S02.5 Fracture of tooth	0.624	0.376	0.000
Y52.5 Other antihypertensive drugs, not elsewhere classified	0.623	0.377	0.000
R45.1 Restlessness and agitation	0.623	0.377	0.000
W16 Diving or jumping into water causing injury other than drowning or submersion	0.623	0.377	0.000
W14 Fall from tree	0.623	0.377	0.000
W12 Fall on and from scaffolding	0.623	0.377	0.000
W11 Fall on and from ladder	0.623	0.377	0.000
W09 Fall involving playground equipment	0.623	0.377	0.000
W05 Fall involving wheelchair	0.623	0.377	0.000
W04 Fall while being carried or supported by other persons	0.623	0.377	0.000
W03 Other fall on same level due to collision with, or pushing by, another person	0.623	0.377	0.000
W01 Fall on same level from slipping, tripping and stumbling	0.623	0.377	0.000
W00 Fall on same level involving ice and snow	0.623	0.377	0.000
T20 Burn and corrosion of head and neck	0.623	0.377	0.000
T86 Failure and rejection of transplanted organs and tissues	0.623	0.377	0.000
Y51 Drugs primarily affecting the autonomic nervous system	0.622	0.378	0.000
M25.59 Pain in joint (Site unspecified)	0.622	0.378	0.000
G44.8 Other specified headache syndromes	0.622	0.378	0.000
R65.1 Systemic Inflammatory Response Syndrome of infectious origin with organ failure	0.622	0.378	0.000
E34 Other endocrine disorders	0.621	0.379	0.000
S01 Open wound of head	0.621	0.379	0.000
I60 Subarachnoid haemorrhage	0.620	0.380	0.000
M46.99 Inflammatory spondylopathy, unspecified (Site unspecified)	0.620	0.380	0.000
E27.5 Adrenomedullary hyperfunction	0.620	0.380	0.000
E27.3 Drug-induced adrenocortical insufficiency	0.620	0.380	0.000
E27.0 Other adrenocortical overactivity	0.620	0.380	0.000
I95-I99 Other and unspecified disorders of the circulatory system	0.620	0.380	0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism	0.620	0.380	0.000
R46.4 Slowness and poor responsiveness	0.620	0.380	0.000
I73.1 Thromboangiitis obliterans [Buerger]	0.620	0.380	0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders	0.620	0.380	0.000
I72.3 Aneurysm of iliac artery	0.619	0.381	0.000
M31 Other necrotising vasculopathies	0.618	0.382	0.000
S00.7 Multiple superficial injuries of head	0.618	0.382	0.000
W07.0 Home	0.618	0.382	0.000
Y45.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.617	0.383	0.000
T39.1 4-Aminophenol derivatives	0.617	0.383	0.000
S98 Traumatic amputation of ankle and foot	0.617	0.383	0.000
S97 Crushing injury of ankle and foot	0.617	0.383	0.000
S96 Injury of muscle and tendon at ankle and foot level	0.617	0.383	0.000
S95 Injury of blood vessels at ankle and foot level	0.617	0.383	0.000
S94 Injury of nerves at ankle and foot level	0.617	0.383	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations