TreeWAS – Variant ID: rs12898290

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
# Top node	1.000	0.000	0.000
Chapter XX External causes of morbidity and mortality	1.000	0.000	0.000
Chapter IX Diseases of the circulatory system	0.999	0.001	0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.999	0.001	0.000
N18 Chronic renal failure	0.998	0.002	0.000
N18.3 Chronic kidney disease, stage 3	0.998	0.002	0.000
I60-I69 Cerebrovascular diseases	0.995	0.005	0.000
Chapter II Neoplasms	0.995	0.005	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.993	0.007	0.000
N17-N19 Renal failure	0.993	0.007	0.000
C15-C26 Malignant neoplasms of digestive organs	0.990	0.010	0.000
Chapter XIV Diseases of the genitourinary system	0.988	0.012	0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.987	0.013	0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.987	0.013	0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.982	0.018	0.000
I69 Sequelae of cerebrovascular disease	0.979	0.021	0.000
N00-N08 Glomerular diseases	0.977	0.023	0.000
D37-D48 Neoplasms of uncertain or unknown behaviour	0.971	0.029	0.000
I26 Pulmonary embolism	0.962	0.038	0.000
S00-S09 Injuries to the head	0.959	0.041	0.000
C20 Malignant neoplasm of rectum	0.959	0.041	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.958	0.042	0.000
Chapter VI Diseases of the nervous system	0.956	0.044	0.000
I69.3 Sequelae of cerebral infarction	0.954	0.046	0.000
C64-C68 Malignant neoplasms of urinary tract	0.952	0.048	0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue	0.950	0.050	0.000
I05-I09 Chronic rheumatic heart diseases	0.948	0.052	0.000
I26.9 Pulmonary embolism without mention of acute cor pulmonale	0.944	0.056	0.000
N18.9 Chronic renal failure, unspecified	0.943	0.057	0.000
N18.5 Chronic kidney disease, stage 5	0.941	0.059	0.000
N03 Chronic nephritic syndrome	0.936	0.064	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.933	0.067	0.000
V10-V19 Pedal cyclist injured in transport accident	0.932	0.068	0.000
G80-G83 Cerebral palsy and other paralytic syndromes	0.931	0.069	0.000
C67 Malignant neoplasm of bladder	0.925	0.075	0.000
M70-M79 Other soft tissue disorders	0.921	0.079	0.000
D46 Myelodysplastic syndromes	0.920	0.080	0.000
M15-M19 Arthrosis	0.919	0.081	0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.915	0.085	0.000
M86-M90 Other osteopathies	0.912	0.088	0.000
Y42.7 Androgens and anabolic congeners	0.911	0.089	0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction	0.909	0.090	0.000
N02 Recurrent and persistent haematuria	0.908	0.092	0.000
G81 Hemiplegia	0.908	0.092	0.000
N03.9 Unspecified	0.907	0.093	0.000
S90-S99 Injuries to the ankle and foot	0.906	0.094	0.000
M05-M14 Inflammatory polyarthropathies	0.904	0.096	0.000
M19 Other arthrosis	0.903	0.097	0.000
I08 Multiple valve diseases	0.896	0.104	0.000
M19.9 Arthrosis, unspecified	0.893	0.107	0.000
Y57 Other and unspecified drugs and medicaments	0.893	0.107	0.000
I27 Other pulmonary heart diseases	0.891	0.109	0.000
G81.9 Hemiplegia, unspecified	0.891	0.109	0.000
S00 Superficial injury of head	0.890	0.110	0.000
I60 Subarachnoid haemorrhage	0.890	0.110	0.000
N18.2 Chronic kidney disease, stage 2	0.889	0.111	0.000
I08.0 Disorders of both mitral and aortic valves	0.884	0.116	0.000
D46.9 Myelodysplastic syndrome, unspecified	0.883	0.117	0.000
Chapter I Certain infectious and parasitic diseases	0.876	0.124	0.000
I10-I15 Hypertensive diseases	0.875	0.125	0.000
D41 Neoplasm of uncertain or unknown behaviour of urinary organs	0.872	0.128	0.000
M80-M85 Disorders of bone density and structure	0.872	0.128	0.000
M13 Other arthritis	0.872	0.128	0.000
V18 Pedal cyclist injured in noncollision transport accident	0.871	0.129	0.000
D66 Hereditary factor VIII deficiency	0.868	0.132	0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere	0.866	0.134	0.000
C45 Mesothelioma	0.865	0.135	0.000
C21 Malignant neoplasm of anus and anal canal	0.865	0.135	0.000
S50-S59 Injuries to the elbow and forearm	0.862	0.138	0.000
M19.99 Arthrosis, unspecified (Site unspecified)	0.860	0.140	0.000
N02.8 Other	0.858	0.142	0.000
Y42.0 Glucocorticoids and synthetic analogs	0.857	0.143	0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.856	0.144	0.000
C18 Malignant neoplasm of colon	0.856	0.144	0.000
T20-T25 Burns and corrosions of external body surface, specified by site	0.853	0.147	0.000
Y52 Agents primarily affecting the cardiovascular system	0.853	0.147	0.000
M13.9 Arthritis, unspecified	0.850	0.150	0.000
D69 Purpura and other haemorrhagic conditions	0.849	0.151	0.000
I65.2 Occlusion and stenosis of carotid artery	0.848	0.152	0.000
G00-G09 Inflammatory diseases of the central nervous system	0.847	0.153	0.000
N19 Unspecified renal failure	0.842	0.158	0.000
M19.90 Arthrosis, unspecified (Multiple sites)	0.838	0.162	0.000
Q20-Q28 Congenital malformations of the circulatory system	0.836	0.164	0.000
V18.0 Driver injured in nontraffic accident	0.836	0.164	0.000
M13.97 Arthritis, unspecified (Ankle and foot)	0.835	0.165	0.000
M87 Osteonecrosis	0.833	0.167	0.000
N18.0 End-stage renal disease	0.833	0.167	0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions	0.833	0.167	0.000
S06 Intracranial injury	0.829	0.171	0.000
G83 Other paralytic syndromes	0.828	0.172	0.000
C67.5 Bladder neck	0.826	0.174	0.000
S00.1 Contusion of eyelid and periocular area	0.826	0.174	0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs	0.826	0.174	0.000
M19.98 Arthrosis, unspecified (Other)	0.825	0.175	0.000
S80-S89 Injuries to the knee and lower leg	0.824	0.176	0.000
I27.0 Primary pulmonary hypertension	0.822	0.178	0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.821	0.179	0.000
Y43 Primarily systemic agents	0.820	0.180	0.000
I60.3 Subarachnoid haemorrhage from posterior communicating artery	0.819	0.181	0.000
Q80-Q89 Other congenital malformations	0.817	0.183	0.000
C26 Malignant neoplasm of other and ill-defined digestive organs	0.815	0.185	0.000
D40 Neoplasm of uncertain or unknown behaviour of male genital organs	0.812	0.188	0.000
C49 Malignant neoplasm of other connective and soft tissue	0.811	0.189	0.000
M77 Other enthesopathies	0.809	0.191	0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.807	0.193	0.000
D41.4 Bladder	0.807	0.193	0.000
S60-S69 Injuries to the wrist and hand	0.805	0.195	0.000
C18.2 Ascending colon	0.804	0.196	0.000
S82 Fracture of lower leg, including ankle	0.800	0.200	0.000
S02 Fracture of skull and facial bones	0.797	0.203	0.000
W50-W64 Exposure to animate mechanical forces	0.796	0.204	0.000
I70-I79 Diseases of arteries, arterioles and capillaries	0.795	0.205	0.000
M71 Other bursopathies	0.794	0.206	0.000
C24 Malignant neoplasm of other and unspecified parts of biliary tract	0.793	0.207	0.000
M19.95 Arthrosis, unspecified (Pelvic region and thigh)	0.788	0.212	0.000
Y47 Sedatives, hypnotics and antianxiety drugs	0.788	0.212	0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system	0.787	0.213	0.000
W00-W19 Falls	0.786	0.214	0.000
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level	0.786	0.214	0.000
Y42.3 Insulin and oral hypoglycaemic [antidiabetic] drugs	0.782	0.218	0.000
G30-G32 Other degenerative diseases of the nervous system	0.782	0.218	0.000
M91-M94 Chondropathies	0.781	0.219	0.000
Y42.5 Other oestrogens and progestogens	0.781	0.219	0.000
C22 Malignant neoplasm of liver and intrahepatic bile ducts	0.781	0.219	0.000
C67.0 Trigone of bladder	0.779	0.220	0.000
Y60-Y69 Misadventures to patients during surgical and medical care	0.777	0.222	0.000
M87.9 Osteonecrosis, unspecified	0.777	0.223	0.000
C66 Malignant neoplasm of ureter	0.776	0.224	0.000
D80-D89 Certain disorders involving the immune mechanism	0.776	0.224	0.000
C67.9 Bladder, unspecified	0.774	0.226	0.000
Y42.8 Other and unspecified hormones and their synthetic substitutes	0.774	0.226	0.000
V40-V49 Car occupant injured in transport accident	0.774	0.226	0.000
M40-M43 Deforming dorsopathies	0.773	0.227	0.000
Y95 Nosocomial condition	0.771	0.229	0.000
Y57.9 Drug or medicament, unspecified	0.770	0.230	0.000
C16 Malignant neoplasm of stomach	0.770	0.230	0.000
Y51 Drugs primarily affecting the autonomic nervous system	0.769	0.231	0.000
B07 Viral warts	0.766	0.234	0.000
X58-X59 Accidental exposure to other and unspecified factors	0.766	0.234	0.000
X50-X57 Overexertion, travel and privation	0.765	0.235	0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs	0.765	0.235	0.000
M13.96 Arthritis, unspecified (Lower leg)	0.764	0.236	0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure	0.763	0.237	0.000
Y46 Antiepileptics and anti-Parkinsonism drugs	0.763	0.237	0.000
M13.90 Arthritis, unspecified (Multiple sites)	0.761	0.239	0.000
I69.0 Sequelae of subarachnoid haemorrhage	0.760	0.240	0.000
X10-X19 Contact with heat and hot substances	0.760	0.240	0.000
I69.8 Sequelae of other and unspecified cerebrovascular diseases	0.757	0.243	0.000
S02.2 Fracture of nasal bones	0.756	0.244	0.000
Y49 Psychotropic drugs, not elsewhere classified	0.755	0.244	0.000
T79-T79 Certain early complications of trauma	0.755	0.245	0.000
Y52.4 Angiotensin-converting-enzyme inhibitors	0.755	0.245	0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.754	0.246	0.000
C45.9 Mesothelioma, unspecified	0.753	0.247	0.000
M72 Fibroblastic disorders	0.753	0.247	0.000
C67.8 Overlapping lesion of bladder	0.752	0.248	0.000
C48 Malignant neoplasm of retroperitoneum and peritoneum	0.751	0.249	0.000
I69.1 Sequelae of intracerebral haemorrhage	0.751	0.249	0.000
S10-S19 Injuries to the neck	0.750	0.250	0.000
G90-G99 Other disorders of the nervous system	0.749	0.251	0.000
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites	0.748	0.252	0.000
S06.0 Concussion	0.748	0.252	0.000
M70 Soft tissue disorders related to use, overuse and pressure	0.747	0.253	0.000
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction	0.747	0.253	0.000
N04 Nephrotic syndrome	0.744	0.256	0.000
I12 Hypertensive renal disease	0.743	0.257	0.000
I05 Rheumatic mitral valve diseases	0.743	0.257	0.000
I61 Intracerebral haemorrhage	0.742	0.258	0.000
Q00-Q07 Congenital malformations of the nervous system	0.741	0.259	0.000
S82.6 Fracture of lateral malleolus	0.741	0.259	0.000
M15 Polyarthrosis	0.740	0.260	0.000
S00.0 Superficial injury of scalp	0.739	0.261	0.000
S92 Fracture of foot, except ankle	0.739	0.261	0.000
M87.95 Osteonecrosis, unspecified (Pelvic region and thigh)	0.737	0.263	0.000
T66-T78 Other and unspecified effects of external causes	0.735	0.265	0.000
S01 Open wound of head	0.735	0.265	0.000
S62 Fracture at wrist and hand level	0.735	0.265	0.000
M06 Other rheumatoid arthritis	0.735	0.265	0.000
C17 Malignant neoplasm of small intestine	0.733	0.267	0.000
S05 Injury of eye and orbit	0.731	0.269	0.000
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands	0.731	0.269	0.000
X40-X49 Accidental poisoning by and exposure to noxious substances	0.730	0.269	0.000
W20-W49 Exposure to inanimate mechanical forces	0.730	0.270	0.000
S82.3 Fracture of lower end of tibia	0.730	0.270	0.000
M89 Other disorders of bone	0.730	0.270	0.000
M77.4 Metatarsalgia	0.729	0.271	0.000
C21.0 Anus, unspecified	0.728	0.272	0.000
M19.96 Arthrosis, unspecified-Lower leg	0.728	0.272	0.000
N25-N29 Other disorders of kidney and ureter	0.728	0.272	0.000
M84 Disorders of continuity of bone	0.728	0.272	0.000
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue	0.727	0.273	0.000
S02.20 Fracture of nasal bones (closed)	0.727	0.273	0.000
S00.7 Multiple superficial injuries of head	0.725	0.275	0.000
Q66 Congenital deformities of feet	0.724	0.276	0.000
S82.8 Fractures of other parts of lower leg	0.722	0.278	0.000
V11 Pedal cyclist injured in collision with other pedal cycle	0.721	0.279	0.000
N05 Unspecified nephritic syndrome	0.720	0.280	0.000
I64 Stroke, not specified as haemorrhage or infarction	0.720	0.280	0.000
B15-B19 Viral hepatitis	0.720	0.280	0.000
I73 Other peripheral vascular diseases	0.720	0.280	0.000
B02 Zoster [herpes zoster]	0.719	0.281	0.000
D69.6 Thrombocytopenia, unspecified	0.718	0.282	0.000
I63 Cerebral infarction	0.718	0.282	0.000
M76 Enthesopathies of lower limb, excluding foot	0.717	0.283	0.000
Chapter XVI Certain conditions originating in the perinatal period	0.717	0.283	0.000
Y35-Y36 Legal intervention and operations of war	0.717	0.283	0.000
Y10-Y34 Event of undetermined intent	0.717	0.283	0.000
Y00-Y09 Assault	0.717	0.283	0.000
X85-X99 Assault	0.717	0.283	0.000
X30-X39 Exposure to forces of nature	0.717	0.283	0.000
X00-X09 Exposure to smoke, fire and flames	0.717	0.283	0.000
W75-W84 Other accidental threats to breathing	0.717	0.283	0.000
W65-W74 Accidental drowning and submersion	0.717	0.283	0.000
V98-V99 Other and unspecified transport accidents	0.717	0.283	0.000
V95-V97 Air and space transport accidents	0.717	0.283	0.000
V90-V94 Water transport accidents	0.717	0.283	0.000
V70-V79 Bus occupant injured in transport accident	0.717	0.283	0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident	0.717	0.283	0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident	0.717	0.283	0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident	0.717	0.283	0.000
V01-V09 Pedestrian injured in transport accident	0.717	0.283	0.000
I00-I02 Acute rheumatic fever	0.716	0.283	0.000
Y59 Other and unspecified vaccines and biological substances	0.716	0.284	0.000
Y58 Bacterial vaccines	0.716	0.284	0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system	0.716	0.284	0.000
Y53 Agents primarily affecting the gastro-intestinal system	0.716	0.284	0.000
Y50 Central nervous system stimulants, not elsewhere classified	0.716	0.284	0.000
Y48 Anaesthetics and therapeutic gases	0.716	0.284	0.000
N18.8 Other chronic renal failure	0.716	0.284	0.000
N18.1 Chronic kidney disease, stage 1	0.716	0.284	0.000
I60.8 Other subarachnoid haemorrhage	0.715	0.285	0.000
G62 Other polyneuropathies	0.715	0.285	0.000
M86 Osteomyelitis	0.714	0.286	0.000
G83.2 Monoplegia of upper limb	0.714	0.286	0.000
I68 Cerebrovascular disorders in diseases classified elsewhere	0.713	0.286	0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction	0.713	0.286	0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites	0.713	0.287	0.000
C40-C41 Malignant neoplasms of bone and articular cartilage	0.713	0.287	0.000
Q50-Q56 Congenital malformations of genital organs	0.713	0.287	0.000
S91 Open wound of ankle and foot	0.713	0.287	0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure	0.713	0.287	0.000
T00-T07 Injuries involving multiple body regions	0.712	0.288	0.000
C67.2 Lateral wall of bladder	0.711	0.289	0.000
C23 Malignant neoplasm of gallbladder	0.711	0.289	0.000
Q76 Congenital malformations of spine and bony thorax	0.710	0.290	0.000
N08 Glomerular disorders in diseases classified elsewhere	0.710	0.290	0.000
D41.2 Ureter	0.709	0.291	0.000
Y57.8 Other drugs and medicaments	0.708	0.292	0.000
D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs	0.708	0.292	0.000
T33-T35 Frostbite	0.708	0.292	0.000
T26-T28 Burns and corrosions confined to eye and internal organs	0.708	0.292	0.000
I28 Other diseases of pulmonary vessels	0.708	0.292	0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites	0.708	0.292	0.000
Y42.6 Antigonadotrophins, antioestrogens, antiandrogens, not elsewhere classified	0.707	0.293	0.000
C45.0 Mesothelioma of pleura	0.706	0.294	0.000
C21.1 Anal canal	0.705	0.295	0.000
M60-M63 Disorders of muscles	0.705	0.295	0.000
Y42.9 Other and unspecified hormone antagonists	0.704	0.296	0.000
Y42.4 Oral contraceptives	0.704	0.296	0.000
Y42.2 Antithyroid drugs	0.704	0.296	0.000
Y42.1 Thyroid hormones and substitutes	0.704	0.296	0.000
S01.8 Open wound of other parts of head	0.704	0.296	0.000
B25-B34 Other viral diseases	0.703	0.297	0.000
V20-V29 Motorcycle rider injured in transport accident	0.702	0.298	0.000
I69.2 Sequelae of other nontraumatic intracranial haemorrhage	0.702	0.298	0.000
S56 Injury of muscle and tendon at forearm level	0.702	0.298	0.000
M19.1 Posttraumatic arthrosis of other joints	0.701	0.299	0.000
X20-X29 Contact with venomous animals and plants	0.700	0.299	0.000
N07 Hereditary nephropathy, not elsewhere classified	0.700	0.299	0.000
N06 Isolated proteinuria with specified morphological lesion	0.700	0.299	0.000
N01 Rapidly progressive nephritic syndrome	0.700	0.299	0.000
N00 Acute nephritic syndrome	0.700	0.299	0.000
C18.8 Overlapping lesion of colon	0.700	0.300	0.000
D55-D59 Haemolytic anaemias	0.699	0.300	0.000
S82.60 Fracture of lateral malleolus (closed)	0.698	0.302	0.000
Y43.1 Antineoplastic antimetabolites	0.698	0.302	0.000
V80-V89 Other land transport accidents	0.698	0.302	0.000
M45-M49 Spondylopathies	0.697	0.303	0.000
M71.2 Synovial cyst of popliteal space [Baker]	0.697	0.303	0.000
Y40 Systemic antibiotics	0.696	0.303	0.000
C49.2 Connective and soft tissue of lower limb, including hip	0.696	0.304	0.000
D42 Neoplasm of uncertain or unknown behaviour of meninges	0.696	0.304	0.000
D39 Neoplasm of uncertain or unknown behaviour of female genital organs	0.696	0.304	0.000
M00-M03 Infectious arthropathies	0.695	0.305	0.000
I60.9 Subarachnoid haemorrhage, unspecified	0.694	0.305	0.000
Y45.1 Salicylates	0.694	0.306	0.000
I07 Rheumatic tricuspid valve diseases	0.694	0.306	0.000
M19.92 Arthrosis, unspecified (Upper arm)	0.693	0.307	0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism	0.693	0.307	0.000
D69.3 Idiopathic thrombocytopenic purpura	0.692	0.308	0.000
C18.6 Descending colon	0.691	0.309	0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs	0.691	0.309	0.000
Y44 Agents primarily affecting blood constituents	0.690	0.310	0.000
I26.0 Pulmonary embolism with mention of acute cor pulmonale	0.690	0.310	0.000
S00.3 Superficial injury of nose	0.689	0.311	0.000
S06.00 Concussion (without open intracranial wound)	0.689	0.311	0.000
W18 Other fall on same level	0.689	0.311	0.000
C26.0 Intestinal tract, part unspecified	0.689	0.311	0.000
D69.4 Other primary thrombocytopenia	0.688	0.312	0.000
S08 Traumatic amputation of part of head	0.688	0.312	0.000
S07 Crushing injury of head	0.688	0.312	0.000
S04 Injury of cranial nerves	0.688	0.312	0.000
S03 Dislocation, sprain and strain of joints and ligaments of head	0.688	0.312	0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.687	0.313	0.000
Q35-Q37 Cleft lip and cleft palate	0.687	0.313	0.000
Q30-Q34 Congenital malformations of the respiratory system	0.687	0.313	0.000
X60-X84 Intentional self-harm	0.684	0.316	0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified	0.684	0.316	0.000
G09 Sequelae of inflammatory diseases of central nervous system	0.683	0.316	0.000
C68 Malignant neoplasm of other and unspecified urinary organs	0.683	0.317	0.000
C65 Malignant neoplasm of renal pelvis	0.683	0.317	0.000
C47 Malignant neoplasm of peripheral nerves and autonomic nervous system	0.681	0.319	0.000
C46 Kaposi's sarcoma	0.681	0.319	0.000
C16.0 Cardia	0.681	0.319	0.000
Y41 Other systemic anti-infectives and antiparasitics	0.680	0.320	0.000
Y57.5 X-ray contrast media	0.680	0.320	0.000
S82.30 Fracture of lower end of tibia (closed)	0.680	0.320	0.000
I27.2 Other secondary pulmonary hypertension	0.680	0.320	0.000
S06.9 Intracranial injury, unspecified	0.680	0.320	0.000
I09 Other rheumatic heart diseases	0.679	0.321	0.000
I06 Rheumatic aortic valve diseases	0.679	0.321	0.000
T31 Burns classified according to extent of body surface involved	0.679	0.321	0.000
I95-I99 Other and unspecified disorders of the circulatory system	0.678	0.322	0.000
M80 Osteoporosis with pathological fracture	0.677	0.323	0.000
Q38-Q45 Other congenital malformations of the digestive system	0.677	0.323	0.000
D40.0 Prostate	0.677	0.323	0.000
A80-A89 Viral infections of the central nervous system	0.676	0.324	0.000
G01 Meningitis in bacterial diseases classified elsewhere	0.676	0.324	0.000
M85 Other disorders of bone density and structure	0.676	0.324	0.000
S00.2 Other superficial injuries of eyelid and periocular area	0.676	0.324	0.000
M79 Other soft tissue disorders, not elsewhere classified	0.673	0.327	0.000
M77.47 Metatarsalgia-Ankle/Foot	0.672	0.328	0.000
Q83 Congenital malformations of breast	0.672	0.328	0.000
I10 Essential (primary) hypertension	0.672	0.328	0.000
A50-A64 Infections with a predominantly sexual mode of transmission	0.672	0.328	0.000
N03.8 Other	0.671	0.329	0.000
N03.7 Diffuse crescentic glomerulonephritis	0.671	0.329	0.000
N03.6 Dense deposit disease	0.671	0.329	0.000
N03.5 Diffuse mesangiocapillary glomerulonephritis	0.671	0.329	0.000
N03.4 Diffuse endocapillary proliferative glomerulonephritis	0.671	0.329	0.000
N03.3 Diffuse mesangial proliferative glomerulonephritis	0.671	0.329	0.000
N03.2 Diffuse membranous glomerulonephritis	0.671	0.329	0.000
N03.1 Focal and segmental glomerular lesions	0.671	0.329	0.000
N03.0 Minor glomerular abnormality	0.671	0.329	0.000
S82.80 Fractures of other parts of lower leg (closed)	0.670	0.330	0.000
I15 Secondary hypertension	0.669	0.330	0.000
I73.9 Peripheral vascular disease, unspecified	0.669	0.331	0.000
M72.2 Plantar fascial fibromatosis	0.669	0.331	0.000
S52 Fracture of forearm	0.669	0.331	0.000
V19 Pedal cyclist injured in other and unspecified transport accidents	0.668	0.332	0.000
V17 Pedal cyclist injured in collision with fixed or stationary object	0.668	0.332	0.000
V16 Pedal cyclist injured in collision with other nonmotor vehicle	0.668	0.332	0.000
V15 Pedal cyclist injured in collision with railway train or railway vehicle	0.668	0.332	0.000
V14 Pedal cyclist injured in collision with heavy transport vehicle or bus	0.668	0.332	0.000
V13 Pedal cyclist injured in collision with car, pick-up truck or van	0.668	0.332	0.000
V12 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle	0.668	0.332	0.000
V10 Pedal cyclist injured in collision with pedestrian or animal	0.668	0.332	0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use	0.668	0.332	0.000
D86 Sarcoidosis	0.667	0.333	0.000
C22.1 Intrahepatic bile duct carcinoma	0.667	0.333	0.000
S50 Superficial injury of forearm	0.667	0.333	0.000
I67 Other cerebrovascular diseases	0.667	0.333	0.000
G04 Encephalitis, myelitis and encephalomyelitis	0.666	0.334	0.000
Q23 Congenital malformations of aortic and mitral valves	0.665	0.335	0.000
T22 Burn and corrosion of shoulder and upper limb, except wrist and hand	0.665	0.335	0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified	0.664	0.336	0.000
Q27 Other congenital malformations of peripheral vascular system	0.664	0.336	0.000
C67.7 Urachus	0.663	0.337	0.000
C67.4 Posterior wall of bladder	0.663	0.337	0.000
C67.1 Dome of bladder	0.663	0.337	0.000
C45.7 Mesothelioma of other sites	0.663	0.337	0.000
S64 Injury of nerves at wrist and hand level	0.663	0.337	0.000
Q67 Congenital musculoskeletal deformities of head, face, spine and chest	0.662	0.337	0.000
M96 Postprocedural musculoskeletal disorders, not elsewhere classified	0.662	0.338	0.000
T20 Burn and corrosion of head and neck	0.661	0.339	0.000
G35-G37 Demyelinating diseases of the central nervous system	0.660	0.340	0.000
M73 Soft tissue disorders in diseases classified elsewhere	0.660	0.340	0.000
I08.2 Disorders of both aortic and tricuspid valves	0.660	0.340	0.000
N02.9 Unspecified	0.660	0.340	0.000
D46.7 Other myelodysplastic syndromes	0.659	0.340	0.000
D46.6 Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality	0.659	0.340	0.000
D46.5 Refractory anaemia with multi-lineage dysplasia	0.659	0.340	0.000
D46.4 Refractory anaemia, unspecified	0.659	0.340	0.000
D46.3 Refractory anaemia with excess of blasts with transformation	0.659	0.340	0.000
D46.2 Refractory anaemia with excess of blasts	0.659	0.340	0.000
D46.1 Refractory anaemia with sideroblasts	0.659	0.340	0.000
D46.0 Refractory anaemia without sideroblasts, so stated	0.659	0.340	0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx	0.659	0.340	0.000
S93.1 Dislocation of toe(s)	0.659	0.341	0.000
M81 Osteoporosis without pathological fracture	0.659	0.341	0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.659	0.341	0.000
B90-B94 Sequelae of infectious and parasitic diseases	0.658	0.342	0.000
D69.9 Haemorrhagic condition, unspecified	0.658	0.342	0.000
G83.4 Cauda equina syndrome	0.658	0.342	0.000
I77 Other disorders of arteries and arterioles	0.657	0.343	0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.657	0.343	0.000
B65-B83 Helminthiases	0.656	0.344	0.000
D67 Hereditary factor IX deficiency	0.656	0.344	0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.656	0.344	0.000
C60-C63 Malignant neoplasms of male genital organs	0.655	0.345	0.000
T24 Burn and corrosion of hip and lower limb, except ankle and foot	0.654	0.346	0.000
S90 Superficial injury of ankle and foot	0.654	0.346	0.000
D48.5 Skin	0.653	0.347	0.000
I65.9 Occlusion and stenosis of unspecified precerebral artery	0.652	0.348	0.000
I65.8 Occlusion and stenosis of other precerebral artery	0.652	0.348	0.000
I65.3 Occlusion and stenosis of multiple and bilateral precerebral arteries	0.652	0.348	0.000
I65.1 Occlusion and stenosis of basilar artery	0.652	0.348	0.000
I65.0 Occlusion and stenosis of vertebral artery	0.652	0.348	0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts	0.652	0.348	0.000
G70-G73 Diseases of myoneural junction and muscle	0.652	0.348	0.000
N02.7 Diffuse crescentic glomerulonephritis	0.651	0.349	0.000
N02.6 Dense deposit disease	0.651	0.349	0.000
N02.5 Diffuse mesangiocapillary glomerulonephritis	0.651	0.349	0.000
N02.4 Diffuse endocapillary proliferative glomerulonephritis	0.651	0.349	0.000
N02.3 Diffuse mesangial proliferative glomerulonephritis	0.651	0.349	0.000
N02.2 Diffuse membranous glomerulonephritis	0.651	0.349	0.000
N02.1 Focal and segmental glomerular lesions	0.651	0.349	0.000
N02.0 Minor glomerular abnormality	0.651	0.349	0.000
I12.0 Hypertensive renal disease with renal failure	0.651	0.349	0.000
Q82 Other congenital malformations of skin	0.651	0.349	0.000
G81.1 Spastic hemiplegia	0.651	0.349	0.000
G81.0 Flaccid hemiplegia	0.651	0.349	0.000
B50-B64 Protozoal diseases	0.650	0.349	0.000
Y45.0 Opioids and related analgesics	0.650	0.350	0.000
S98 Traumatic amputation of ankle and foot	0.649	0.350	0.000
S97 Crushing injury of ankle and foot	0.649	0.350	0.000
S96 Injury of muscle and tendon at ankle and foot level	0.649	0.350	0.000
S95 Injury of blood vessels at ankle and foot level	0.649	0.350	0.000
S94 Injury of nerves at ankle and foot level	0.649	0.350	0.000
W55 Bitten or struck by other mammals	0.649	0.351	0.000
M14 Arthropathies in other diseases classified elsewhere	0.648	0.352	0.000
M12 Other specific arthropathies	0.648	0.352	0.000
M09 Juvenile arthritis in diseases classified elsewhere	0.648	0.352	0.000
M08 Juvenile arthritis	0.648	0.352	0.000
S99 Other and unspecified injuries of ankle and foot	0.648	0.352	0.000
C67.6 Ureteric orifice	0.648	0.352	0.000
M94 Other disorders of cartilage	0.648	0.352	0.000
M19.8 Other specified arthrosis	0.647	0.353	0.000
M19.2 Other secondary arthrosis	0.647	0.353	0.000
T21 Burn and corrosion of trunk	0.647	0.353	0.000
M19.93 Arthrosis, unspecified (Forearm)	0.646	0.354	0.000
C25 Malignant neoplasm of pancreas	0.645	0.355	0.000
Y84 Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure	0.644	0.356	0.000
S51 Open wound of forearm	0.644	0.356	0.000
C18.7 Sigmoid colon	0.643	0.357	0.000
I08.9 Multiple valve disease, unspecified	0.643	0.357	0.000
M95 Other acquired deformities of musculoskeletal system and connective tissue	0.641	0.359	0.000
Y52.5 Other antihypertensive drugs, not elsewhere classified	0.641	0.359	0.000
Y57.7 Vitamins, not elsewhere classified	0.640	0.360	0.000
Y57.6 Other diagnostic agents	0.640	0.360	0.000
Y57.4 Pharmaceutical excipients	0.640	0.360	0.000
Y57.3 Alcohol deterrents	0.640	0.360	0.000
Y57.2 Antidotes and chelating agents, not elsewhere classified	0.640	0.360	0.000
Y57.1 Lipotropic drugs	0.640	0.360	0.000
Y57.0 Appetite depressants [anorectics]	0.640	0.360	0.000
Q87 Other specified congenital malformation syndromes affecting multiple systems	0.640	0.360	0.000
I27.8 Other specified pulmonary heart diseases	0.639	0.361	0.000
I27.1 Kyphoscoliotic heart disease	0.639	0.361	0.000
B99-B99 Other infectious diseases	0.638	0.361	0.000
S00.5 Superficial injury of lip and oral cavity	0.638	0.362	0.000
S00.4 Superficial injury of ear	0.638	0.362	0.000
I60.7 Subarachnoid haemorrhage from intracranial artery, unspecified	0.638	0.362	0.000
I60.6 Subarachnoid haemorrhage from other intracranial arteries	0.638	0.362	0.000
I60.5 Subarachnoid haemorrhage from vertebral artery	0.638	0.362	0.000
I60.4 Subarachnoid haemorrhage from basilar artery	0.638	0.362	0.000
I60.0 Subarachnoid haemorrhage from carotid siphon and bifurcation	0.638	0.362	0.000
S06.6 Traumatic subarachnoid haemorrhage	0.638	0.362	0.000
C67.3 Anterior wall of bladder	0.638	0.362	0.000
G95 Other diseases of spinal cord	0.638	0.362	0.000
Y43.4 Immunosuppressive agents	0.637	0.363	0.000
Y47.1 Benzodiazepines	0.637	0.363	0.000
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system	0.635	0.365	0.000
T23 Burn and corrosion of wrist and hand	0.635	0.365	0.000
G05 Encephalitis, myelitis and encephalomyelitis in diseases classified elsewhere	0.634	0.365	0.000
M88 Paget's disease of bone [osteitis deformans]	0.634	0.366	0.000
S93.0 Dislocation of ankle joint	0.634	0.366	0.000
G62.9 Polyneuropathy, unspecified	0.634	0.366	0.000
D50-D53 Nutritional anaemias	0.632	0.367	0.001
T15-T19 Effects of foreign body entering through natural orifice	0.632	0.368	0.000
N18.4 Chronic kidney disease, stage 4	0.631	0.369	0.000
Q24 Other congenital malformations of heart	0.629	0.371	0.000
S82.0 Fracture of patella	0.629	0.371	0.000
M71.26 Synovial cyst of popliteal space [Baker]-Lower Leg	0.628	0.372	0.000
I72 Other aneurysm	0.628	0.372	0.000
B85-B89 Pediculosis, acariasis and other infestations	0.628	0.372	0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers	0.628	0.372	0.000
A75-A79 Rickettsioses	0.628	0.372	0.000
A70-A74 Other diseases caused by chlamydiae	0.628	0.372	0.000
A65-A69 Other spirochaetal diseases	0.628	0.372	0.000
A20-A28 Certain zoonotic bacterial diseases	0.628	0.372	0.000
A15-A19 Tuberculosis	0.628	0.372	0.000
C79 Secondary malignant neoplasm of other sites	0.628	0.372	0.000
S06.4 Epidural haemorrhage	0.628	0.372	0.000
G06 Intracranial and intraspinal abscess and granuloma	0.628	0.372	0.000
I13 Hypertensive heart and renal disease	0.627	0.373	0.000
I11 Hypertensive heart disease	0.627	0.373	0.000
C18.0 Caecum	0.627	0.373	0.000
Q21 Congenital malformations of cardiac septa	0.626	0.374	0.000
D41.9 Urinary organ, unspecified	0.625	0.374	0.000
D41.7 Other urinary organs	0.625	0.374	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations